Faculty Profiles - IWANO, Shingo

Papers - IWANO, Shingo

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Mediastinal atlas creation from 3-D chest computed tomography images: application to automated detection and station mapping of lymph nodes. Reviewed

Feuerstein M, Glocker B, Kitasaka T, Nakamura Y, Iwano S, Mori K

Medical image analysis Vol. 16 ( 1 ) page： 63-74 2012.1

Correlation between dual-phase dynamic multi-detector CT findings and fibrosis within lung adenocarcinoma tumors. Reviewed

Iwano S, Koike W, Matsuo K, Okada T, Shimoyama Y, Naganawa S

European journal of radiology Vol. 80 ( 3 ) page： e470-5 2011.12

*Virtual bronchoscopy-guided transbronchial biopsy for aiding the diagnosis of peripheral lung cancer. Reviewed

Iwano S, Imaizumi K, Okada T, Hasegawa Y, Naganawa S.

Eur J Radiol Vol. 79 ( 1 ) page： 155-159 2011.7

Diagnostic value of SPIO-mediated breath-hold, black-blood, fluid-attenuated, inversion recovery (BH-BB-FLAIR) imaging in patients with hepatocellular carcinomas.

MATSUSHIMA MASAYA, NAGANAWA SHINJI, IKEDA MITSURU, ITOH SHIGEKI, OGAWA HIROSHI, KOMADA TOMOHIRO, ISHIGAKI SATOKO, KAWAI HISASHI, SUZUKI KOJIRO, SATAKE HIROKO, IWANO SHINGO

Magn Reason Med Sci Vol. 9 ( 2 ) page： 49-58 2010.9

Estimation of Gadolinium-induced T(1)-shortening with Measurement of Simple Signal Intensity Ratio between the Cochlea and Brain Parenchyma on 3D-FLAIR: Correlation with T(1) Measurement by TI Scout Sequence.

NAGANAWA SHINJI, ISHIHARA SHUNICHI, IWANO SHINGO, KAWAI HISASHI, SONE MICHIHIKO, NAKASHIMA TSUTOMU

Magn Reson Med Sci Vol. 9 ( 1 ) page： 17-22 2010.9

Three-dimensional angiography of aberrant segmental vein of right upper lobe. Reviewed

Usami N, Iwano S, Mizuno T, Taniguchi T, Yokoi K

Asian cardiovascular & thoracic annals Vol. 18 ( 4 ) page： 398 2010.8

Differential TH1/TH2 chemokine expression in interstitial pneumonia. Reviewed

Honda T, Imaizumi K, Yokoi T, Hashimoto N, Hashimoto I, Kawabe T, Matsuo M, Iwano S, Shimokata K, Hasegawa Y.

Am J Med Sci. Vol. 339 ( 1 ) page： 41-48 2010.1

Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T. Reviewed

Naganawa S, Ishihara S, Iwano S, Sone M, Nakashima T.

J Magn Reson Imaging Vol. 31 ( 1 ) page： 210-214 2010

Comparisons of I-123 diagnostic and I-131 post-treatment scans for detecting residual thyroid tissue and metastases of differentiated thyroid cancer. Reviewed

Iwano S, Kato K, Nihashi T, Ito S, Tachi Y, Naganawa S

Annals of nuclear medicine Vol. 23 ( 9 ) page： 777-82 2009.11

Semi-automatic volumetric measurement of lung cancer using multi-detector CT effects of nodule characteristics. Reviewed

Iwano S, Okada T, Koike W, Matsuo K, Toya R, Yamazaki M, Ito S, Ito J, Naganawa S.

Acad Radiol. Vol. 16 ( 10 ) page： 1179-86 2009.10

【ボーダレス時代のPACS&WS選び　高機能化と多機能化が画像診断に福音をもたらす】 PACS&WS導入施設報告　PACSと3D WS併用施設報告　仮想気管支鏡(virtual bronchoscopy)の配信におけるPACSとWSの連携

岩野信吾

INNERVISION Vol. 24 ( 7 ) page： 27-29 2009.6

*3D-CT volumetry of the lung using multidetector row CT: comparison with pulmonary function tests.

Iwano, Shingo; Okada, Tohru; Satake, Hiroko; Naganawa, Shinji

Acad Radiol ( 16 ) page： 250-256 2009.3

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

RATIONALE AND OBJECTIVES: The aim of this study was to evaluate the accuracy of measurements of lung volumes reconstructed using three-dimensional computed tomographic (CT) imaging from thin-section multidetector-row CT images compared to standard pulmonary function testing. MATERIALS AND METHODS: Preoperative three-dimensional CT images and pulmonary function test results of 64 patients with solitary pulmonary nodules who were considered candidates for lung resection were reviewed. On the three-dimensional CT images, total lung capacity (TLC(CTV)), emphysematous lung capacity (ELC(CTV)), and normal lung capacity (NLC(CTV)) were calculated. Total lung capacity (TLC), vital capacity, and forced expiratory volume in 1 second were measured using spirometry. RESULTS: There was a strong positive correlation between estimated TLC(CTV) and measured TLC values (r = 0.87, P < .001). Estimated ELC(CTV) at the threshold value of -900 Hounsfield units was negatively correlated with forced expiratory volume in 1 second (r = -0.56, P < .001). NLC(CTV) values were more strongly correlated with vital capacity values than TLC(CTV) values (r = 0.74, P < .001). CONCLUSIONS: Lung volume calculated using three-dimensional CT volumetry was well correlated with lung volume measured using spirometry. Three-dimensional CT volumetry can be used to evaluate pulmonary function.

Computer-aided diagnosis of lung cancer: definition and detection of ground-glass opacity type of nodules by high-resolution computed tomography. Reviewed

Okada T, Iwano S, Ishigaki T, Kitasaka T, Hirano Y, Mori K, Suenaga Y, Naganawa S.

Jpn J Radiol. Vol. 27 ( 2 ) page： 91-99 2009.2

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The ground-glass opacity (GGO) of lung cancer is identified only subjectively on computed tomography (CT) images as no quantitative characteristic has been defined for GGOs. We sought to define GGOs quantitatively and to differentiate between GGOs and solid-type lung cancers semiautomatically with a computer-aided diagnosis (CAD). METHODS AND MATERIALS: High-resolution CT images of 100 pulmonary nodules (all peripheral lung cancers) were collected from our clinical records. Two radiologists traced the contours of nodules and distinguished GGOs from solid areas. The CT attenuation value of each area was measured. Differentiation between cancer types was assessed by a receiver-operating characteristic (ROC) analysis. RESULTS: The mean CT attenuation of the GGO areas was -618.4 +/- 212.2 HU, whereas that of solid areas was -68.1 +/- 230.3 HU. CAD differentiated between solidand GGO-type lung cancers with a sensitivity of 86.0% and specificity of 96.5% when the threshold value was -370 HU. Four nodules of mixed GGOs were incorrectly classified as the solid type. CAD detected 96.3% of GGO areas when the threshold between GGO and solid areas was 194 HU. CONCLUSION: Objective definition of GGO area by CT attenuation is feasible. This method is useful for semiautomatic differentiation between GGOs and solid types of lung cancer.

Detection of presumed hemorrhage in the ampullar endolymph of the semicircular canal: a case report. Reviewed

Naganawa S, Ishihara S, Iwano S, Sone M, Nakashima T.

Magn Reson Med Sci. Vol. 8 ( 4 ) page： 187-191 2009

Automated anatomical labeling of bronchial branches extracted from CT datasets based on machine learning and combination optimization and its application to bronchoscope guidance. Reviewed

Mori K, Ota S, Deguchi D, Kitasaka T, Suenaga Y, Iwano S, Hasegawa Y, Takabatake H, Mori M, Natori H

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention Vol. 12 ( Pt 2 ) page： 707-14 2009

Diagnostic whole-body scanning before radioiodine therapy for pulmonary metastases of differentiated thyroid cancer: predictive value and recommendations. Reviewed

Tachi Y, Iwano S, Kato K, Tadokoro M, Naganawa S

Clin Nucl Med Vol. 33 ( 12 ) page： 845-51 2008.12

Language：English Publishing type：Research paper (scientific journal)

RATIONALE:: Radioiodine therapy improves the survival of patients with pulmonary metastases of differentiated thyroid cancer (DTC). It is controversial whether the diagnostic whole-body I-131 scan (DWS) before therapy is essential. We determined whether DWS could predict the efficacy of I-131 therapy for pulmonary metastases. METHODS:: We undertook a retrospective review of records of 42 patients (28 women and 14 men, mean age 52.7 years). The patients had received 62 rounds of I-131 therapy for lung metastases of DTC at our institution between June 2002 and June 2006. On the same day that the DWS (dose of 185 MBq) (5 mCi) was completed, the patient received I-131 therapy (dose of 3700-7400 MBq) (100-200 mCi). Post-therapy whole-body scans (PWS) were performed after 3 to 4 days and 7 to 8 days. For all therapies, chest CT images were obtained before I-131 therapy, and 3 and 6 months after therapy for evaluation of therapeutic effectiveness. In addition, serum thyroglobulin (Tg) values were measured before and after the radioiodine therapy for all treatments. RESULTS:: In the group demonstrating I-131 accumulation for pulmonary metastases on DWS, 72% of patients showed a reduction of pulmonary metastases on follow-up CT. On the other hand, in the group that failed to accumulate I-131 on DWS, only 5% of patients showed a reduction of pulmonary metastases. After therapy, serum Tg levels decreased significantly in the group that initially showed accumulation of I-131 in DWS (P = 0.045). In contrast, no remarkable changes between pre- and post-therapy Tg levels were observed in patients who failed to accumulate I-131 in DWS. CONCLUSION:: A whole-body I-131 diagnostic scan before I-131 therapy has a predictive value for the efficacy of therapeutic radioiodine treatment for pulmonary metastases of differentiated thyroid cancer.

Communication between cochlear perilymph and cerebrospinal fluid through the cochlear modiolus visualized after intratympanic administration of Gd-DTPA.

Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Sone, Michihiko; Nakashima, Tsutomu

Radiat Med Vol. 26 page： 597-602 2008.9

*Computer-aided differentiation of malignant from benign solitary pulmonary nodules imaged by high-resolution CT. Reviewed

Iwano S, Nakamura T, Kamioka Y, Ikeda M, Ishigaki T.

Comput Med Imaging Graph. Vol. 32 ( 5 ) page： 416-22. 2008.7

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

We investigated the possibility of using computer analysis of high-resolution CT images to radiologically classify the shape of pulmonary nodules. From a total of 107 HRCT images of solid, solitary pulmonary nodules with prior differentiation as benign (n=55) or malignant (n=52), we extracted the desired pulmonary nodules and calculated two quantitative parameters for characterizing nodules: circularity and second central moment. Using discriminant analysis for two thresholds in differentiating malignant from benign states resulted in a sensitivity of 76.9%, a specificity of 80%, a positive predictive value of 78.4%, and a negative predictive value of 78.6%.

Contrast-enhanced MR imaging of the brain using T1-weighted FLAIR with BLADE compared with a conventional spin-echo sequence.

Naganawa Shinji, Satake Hiroko, Iwano Shingo, Kawai Hisashi, Kubota Seiji, Komada Tomohiro, Kawamura Minako, Sakurai Yasuo, Fukatsu Hiroshi

Eur Radiol Vol. 18 ( 2 ) page： 337-342 2008.2

Interactions of perceptual and conceptual processing:Expertise in medical image diagnosis.

Morita, J., Miwa, K., Kitasaka, T., Mori, K., Suenaga, Y., Iwano, S., Ikeda, M., and Ishigaki, T

Int. J. Human-computer Studies Vol. 66 ( 208 ) page： 370-390 2008

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