Updated on 2024/03/18

写真a

 
IWANO, Shingo
 
Organization
Graduate School of Medicine Program in Integrated Medicine Advanced Medical Science Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 2001.3   名古屋大学 ) 

Research Interests 10

  1. Computed Tmography (CT)

  2. Computer-Aided Diagnosis

  3. Diffuse Pulmonary Disease

  4. Lung Cancer

  5. 胸部画像診断

  6. 肺癌

  7. 画像診断

  8. 甲状腺癌

  9. 核医学

  10. 放射線医学

Research Areas 3

  1. Others / Others  / Radiology

  2. Others / Others  / Internal Medicine Respiratory System

  3. Life Science / Radiological sciences  / Diagnostic Radiology

Current Research Project and SDGs 4

  1. CT Diagnosis of Lung Cancer

  2. 胸部CTのコンピュータ支援診断(CAD)

  3. CT diagnosis of Interstitial Pneumonia

  4. Radioiodine treatment of thyroid cancer

Research History 6

  1. 名古屋大学医学部附属病院   放射線科   診療教授

    2020.4

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    Country:Japan

  2. 名古屋大学大学院医学系研究科分子総合生物学専攻量子医学・准教授

    2010.11

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    Country:Japan

  3. Nagoya University   Graduate School of Medicine Program in Integrated Molecular Medicine   Associate professor

    2010.11

  4. 名古屋大学医学部附属病院放射線科講師

    2007.5 - 2010.10

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    Country:Japan

  5. 名古屋大学医学部附属病院放射線科助教

    2007.4

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    Country:Japan

  6. 名古屋大学医学部附属病院放射線科助手

    2001.1 - 2007.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medicine   radiology

    1994.4 - 1998.1

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 1993

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    Country: Japan

Professional Memberships 6

  1. 日本医学放射線学会

  2. 日本核医学会

  3. 日本肺癌学会

  4. 日本肺癌学会

  5. 日本核医学会

  6. 日本医学放射線学会

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Papers 136

  1. Measurement of solid size in early-stage lung adenocarcinoma by virtual 3D thin-section CT applied artificial intelligence

    Iwano, S; Kamiya, S; Ito, R; Kudo, A; Kitamura, Y; Nakamura, K; Naganawa, S

    SCIENTIFIC REPORTS   Vol. 13 ( 1 )   2023.12

  2. Airway involvement in inflammatory bowel disease: Inflammatory bowel disease patients have bronchial wall thickening Reviewed

    Majima S, Wakahara K, Iwano S, Kinoshita F, Nakamura M, Hashimoto N, Fujishiro M, Hasegawa Y

    RESPIRATORY INVESTIGATION   Vol. 60 ( 5 ) page: 713 - 719   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.resinv.2022.06.003

    DOI: 10.1016/j.resinv.2022.06.003

    Web of Science

    PubMed

  3. Computer-Aided Volumetry by Multidetector Computed Tomography is Efficient for Prognostic Prediction of Early-Stage Solid Lung Cancers

    Kato, T; Iwano, S; Katsuya, R; Okado, S; Ito, T; Sato, K; Nakanishi, K; Kadomatsu, Y; Ueno, H; Ozeki, N; Nakamura, S; Fukumoto, K; Chen-Yoshikawa, TF

    JOURNAL OF THORACIC ONCOLOGY   Vol. 17 ( 9 ) page: S206 - S207   2022.9

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  4. Right ventricular pressure overload related to residual thrombotic burden in patients 1 year after acute pulmonary embolism: From the Nagoya PE study

    Nakano, Y; Adachi, S; Nishiyama, I; Yasuda, K; Yoshida, M; Iwano, S; Kondo, T; Murohara, T

    THROMBOSIS RESEARCH   Vol. 216   page: 113 - 119   2022.8

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  5. Usefulness of a refined computed tomography imaging method to assess the prevalence of residual pulmonary thrombi in patients 1 year after acute pulmonary embolism: The Nagoya PE study Reviewed

    Nakano Y, Adachi S, Nishiyama I, Yasuda K, Imai R, Yoshida M, Iwano S, Kondo T, Murohara T

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS   Vol. 20 ( 4 ) page: 888 - 898   2022.4

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  6. End-Systolic Eccentricity Index Obtained by Enhanced Computed Tomography Is a Predictor of Pulmonary Vascular Resistance in Patients with Chronic Thromboembolic Pulmonary Hypertension Invited Reviewed

    Tsutsumi Y, Adachi S, Nakano Y, Iwano S, Abe S, Kato K, Naganawa S

    LIFE   Vol. 12 ( 4 ) page: 593   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/life12040593

    DOI: 10.3390/life12040593

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    PubMed

  7. Bronchial wall thickening is associated with severity of chronic rhinosinusitis

    Majima, S; Wakahara, K; Nishio, T; Nishio, N; Teranishi, M; Iwano, S; Hirakawa, A; Hashimoto, N; Sone, M; Hasegawa, Y

    RESPIRATORY MEDICINE   Vol. 170   page: 106024   2020.8

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  8. An Empirical Study on the Use of Visual Explanation in Kidney Cancer Detection

    Takahashi, M; Kameya, Y; Yamada, K; Hotta, K; Takahashi, T; Sassa, N; Iwano, S; Yamamoto, T

    TWELFTH INTERNATIONAL CONFERENCE ON DIGITAL IMAGE PROCESSING (ICDIP 2020)   Vol. 11519   2020

  9. Does I-131 uptake in the subhyoid portion or lymph nodes affect the outcome of low-dose ablation therapy for patients with differentiated thyroid cancer?

    Ito, S; Iwano, S; Kato, K; Naganawa, S

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   Vol. 46 ( SUPPL 1 ) page: S662 - S663   2019.10

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  10. Impact of Combined Evaluation Using Tumor Volume and Metastatic Nodal Extent in Stage III NSCLC Treated with CRT

    Tamiya, Y; Morise, M; Matsuzawa, R; Tanaka, I; Okada, T; Iwano, S; Hase, T; Hashimoto, N; Sato, M; Itoh, Y; Hasegawa, Y

    JOURNAL OF THORACIC ONCOLOGY   Vol. 14 ( 10 ) page: S909 - S910   2019.10

  11. Postoperative recurrence of clinical early-stage non-small cell lung cancers: a comparison between solid and subsolid nodules

    Iwano, S; Umakoshi, H; Kamiya, S; Yokoi, K; Kawaguchi, K; Fukui, T; Naganawa, S

    CANCER IMAGING   Vol. 19 ( 1 ) page: 33   2019.6

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  12. Evaluation of intra-tumoral blood feeding to predict the effect of induction therapy in patients with locally advanced lung cancer

    Kawaguchi, K; Fukui, T; Goto, M; Nakamura, S; Hakiri, S; Ozeki, N; Kato, T; Mori, S; Hashimoto, K; Iwano, S; Yokoi, K

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 291 - 301   2019.5

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  13. Prediction of recurrence using volume-based metabolic index obtained by preoperative FDG-PET for non-small-cell lung cancer

    Ito, S; Iwano, S; Kato, K; Naganawa, S

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   Vol. 45   page: S506 - S506   2018.10

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  14. Dense volumetric detection and segmentation of mediastinal lymph nodes in chest CT images

    Oda Hirohisa, Roth Holger R., Bhatia Kanwal K., Oda Masahiro, Kitasaka Takayuki, Iwano Shingo, Homma Hirotoshi, Takabatake Hirotsugu, Mori Masaki, Natori Hiroshi, Schnabel Julia A., Mori Kensaku

    MEDICAL IMAGING 2018: COMPUTER-AIDED DIAGNOSIS   Vol. 10575   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1117/12.2287066

    Web of Science

  15. Risk Factor Evaluation of Programmed Death 1 Inhibitor Related Pneumonitis in Patients with Non-Small Cell Lung Cancer

    Fukihara, J; Sakamoto, K; Iwano, S; Morise, M; Hashimoto, N; Hasegawa, Y

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 197   2018

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  16. Prognostic impact of highly solid component in early-stage solid lung adenocarcinoma. Reviewed International journal

    Taketo Kato, Shingo Iwano, Yuki Hanamatsu, Masato Nakaguro, Ryo Emoto, Shoji Okado, Keiyu Sato, Osamu Noritake, Keita Nakanishi, Yuka Kadomatsu, Harushi Ueno, Naoki Ozeki, Shota Nakamura, Koichi Fukumoto, Tamotsu Takeuchi, Kennosuke Karube, Shigeyuki Matsui, Toyofumi Fengshi Chen-Yoshikawa

    Quantitative imaging in medicine and surgery   Vol. 13 ( 9 ) page: 5641 - +   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Based on computed tomography (CT) findings of lung cancer, solid nodules have a much worse prognosis than subsolid nodules, even if the nodules are subcentimeter in size. There is, however, no systematic method for determining the prognosis of solid tumors on CT. This study aimed to discover the prognostic factor of early-stage solid lung adenocarcinoma using three-dimensional CT volumetry. METHODS: Patients with pathological stage I solid lung adenocarcinoma who underwent complete resection between 2007 and 2012 were selected in this retrospective study. Clinicopathological data and preoperative multidetector CT findings, such as tumor size on the two-dimensional axial image, three-dimensional tumor volume between -600 and 199 HU, and three-dimensional solid volume between 0 and 199 HU, which corresponded to highly solid components, were compared between recurrence and non-recurrence. Furthermore, these radiological values were compared to pathological invasive volume (PIV). RESULTS: During this time, 709 patients had their lung cancer completely removed. From this cohort, 90 patients with pathological stage I solid lung adenocarcinoma were selected. In addition, recurrence was found in 26 patients (28.9%). Although two-dimensional axial image, serum carcinoembryonic antigen (CEA) level, and SUVmax on 18F fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) did not differ statistically between recurrent and non-recurrent patients, three-dimensional tumor and solid tumor volume did. Multivariate analysis indicated that three-dimensional solid tumor volume [hazard ratio: 2.440; 95% confidence interval (CI): 1.110-5.361, P=0.026] and epidermal growth factor receptor (EGFR) mutation (hazard ratio: 4.307; 95% CI: 1.328-13.977, P=0.015) were significantly associated with disease-free survival (DFS). When three-dimensional tumor and solid tumor volume were compared to PIV, three-dimensional solid tumor volume (3,091 mm3 on average) showed a highly similar value with PIV (2,930 mm3 on average), whereas three-dimensional tumor volume (6,175 mm3 on average) was significantly larger than PIV (P<0.001). CONCLUSIONS: In patients with early-stage solid lung adenocarcinoma, the measurement of three-dimensional solid tumor volume, which is correlated with PIV, accurately predicted the postoperative outcome.

    DOI: 10.21037/qims-23-36

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    PubMed

  17. Virtual Bronchoscopy-Guided Transbronchial Biopsy Simulation Using a Head-Mounted Display: A New Style of Flexible Bronchoscopy. Reviewed International journal

    Shotaro Okachi, Takayasu Ito, Kazuhide Sato, Shingo Iwano, Yuka Shinohara, Hideyuki Itoigawa, Naozumi Hashimoto

    Surgical innovation   Vol. 29 ( 6 ) page: 811 - 813   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    Background/need. The increases in reference images and information during bronchoscopy using virtual bronchoscopic navigation (VBN) and fluoroscopy has potentially created the need for support using a head-mounted display (HMD) because bronchoscopists feel difficulty to see displays that are at a distance from them and turn their head and body in various directions. Methodology and device description. The binocular see-through Moverio BT-35E Smart Glasses can be connected via a high-definition multimedia interface and have a 720p high-definition display. We developed a system that converts fluoroscopic (live and reference), VBN, and bronchoscopic image signals through a converter and references them using the Moverio BT-35E. Preliminary results. We performed a virtual bronchoscopy-guided transbronchial biopsy simulation using the system. Four experienced pulmonologists performed a simulated bronchoscopy of 5 cases each with the Moverio BT-35E glasses, using bronchoscopy training model. For all procedures, the bronchoscope was advanced successfully into the target bronchus according to the VBN image. None of the operators reported eye or body fatigue during or after the procedure. Current status. This small-scale simulation study suggests the feasibility of using a HMD during bronchoscopy. For clinical use, it is necessary to evaluate the safety and usefulness of the system in larger clinical trials in the future.

    DOI: 10.1177/15533506211068928

    DOI: 10.1177/15533506211068928

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    PubMed

  18. Diagnostic value and safety of endobronchial ultrasonography with a guide sheath transbronchial biopsy for diagnosing peripheral pulmonary lesions in patients with interstitial lung disease. Reviewed International journal

    Takayasu Ito, Shotaro Okachi, Shingo Iwano, Fumie Kinoshita, Keiko Wakahara, Naozumi Hashimoto, Toyofumi Fengshi Chen-Yoshikawa

    Journal of thoracic disease   Vol. 14 ( 11 ) page: 4361 - 4371   2022.11

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    BACKGROUND: Radial endobronchial ultrasonography transbronchial biopsy with and without a guide sheath is a useful method for diagnosing peripheral pulmonary lesions (PPLs). However, the diagnostic yield and complications of radial endobronchial ultrasonography transbronchial biopsy for PPLs remains elusive in patients with interstitial lung disease (ILD). METHODS: We retrospectively analysed 431 patients (69 with and 362 without ILD) who underwent radial endobronchial ultrasonography with a guide sheath transbronchial biopsy (EBUS-GS TBB) for PPLs from April 1, 2011, to March 31, 2020. We investigated the diagnostic yield and complications of the procedure for PPLs and compared them between patients with and without ILD. We also evaluated the factors contributing to successful diagnosis. RESULTS: The diagnostic yield of radial endobronchial ultrasonography in patients with ILD was significantly lower than in those without ILD (62.3% vs. 75.4%, P=0.024). Multivariate analysis showed that the presence of ILD as background lung [odds ratio (OR) =0.517], probe position within the lesion (OR =4.654), and the presence of solid lesion (OR =1.946) significantly affected the diagnostic yield of PPLs. There was a significant difference in the rate of pneumothorax between the patients with ILD and those without ILD (4.3% vs. 0.6%, P=0.031). CONCLUSIONS: The presence of ILD as the background lung significantly affected the diagnostic yield of PPLs with radial EBUS-GS TBB. Regarding the complications, pneumothorax occurred more frequently in patients with ILD than in those without ILD.

    DOI: 10.21037/jtd-22-809

    DOI: 10.21037/jtd-22-809

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  19. Chest three-dimensional-computed tomography imaging data analysis for the variation of exercise capacity after lung lobectomy. Reviewed International journal

    Naoki Ozeki, Shingo Iwano, Shota Nakamura, Koji Kawaguchi, Yota Mizuno, Takayuki Inoue, Motoki Nagaya, Toyofumi Fengshi Chen-Yoshikawa

    Clinical physiology and functional imaging   Vol. 42 ( 5 ) page: 362 - 371   2022.9

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    BACKGROUND: Postoperative loss of exercise capacity and pulmonary function is a major concern among lung cancer patients. In this study, the time for a stair-climbing to 12-m height was used to investigate whether preoperative chest 3D-computed tomography (CT) could be a useful tool for predicting postoperative variations in exercise capacity and pulmonary function. METHODS: Seventy-eight patients undergoing lobectomy for suspected stage I lung cancer were prospectively enroled. Preoperatively, lobe volume and low attenuation volume (LAV) were evaluated using the SYNAPSE VINCENT system. Preoperative data on stair-climbing time, spirometry and diffusing capacity of the lung for carbon monoxide (DLCO ) at baseline and 6-month postoperative data were used to evaluate variations in exercise capacity and pulmonary function. Maximal oxygen uptake (VO2 t) was evaluated based on the stair-climbing time. RESULTS: Significant differences in the variation of exercise capacity at 6 months postoperatively were found between the groups categorized by target lobe volume and LAV status: The large volume/LAV (+) group had a greater decline in VO2 t. Mean loss of VO2 t was -6.2%, -1.4%, -1.6% and -0.1% in the large volume/LAV (+), large volume/LAV (-), small volume/LAV (+) and small volume/LAV (-) groups, respectively. The large volume/LAV (-) group had a greater decline in forced expiratory volume in 1 s. The small volume/LAV (+) group showed a reduced decline in the DLCO . CONCLUSIONS: Analysis of chest 3D-CT scans is a potential tool for predicting the loss of exercise capacity and pulmonary function after lung lobectomy.

    DOI: 10.1111/cpf.12777

    DOI: 10.1111/cpf.12777

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    PubMed

  20. 人工知能を応用したバーチャル3D thin-section CTを用いた肺腺癌の充実成分径の計測

    岩野 信吾, 神谷 晋一朗, 伊藤 倫太郎, 工藤 彰, 北村 嘉郎, 中村 圭児, 長縄 慎二

    断層映像研究会雑誌   Vol. 49 ( 2 ) page: 39 - 39   2022.9

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    Language:Japanese   Publisher:断層映像研究会  

  21. Features from MRI texture analysis associated with survival outcomes in triple-negative breast cancer patients. Reviewed

    Saki Kamiya, Hiroko Satake, Yoko Hayashi, Satoko Ishigaki, Rintaro Ito, Mariko Kawamura, Toshiaki Taoka, Shingo Iwano, Shinji Naganawa

    Breast cancer (Tokyo, Japan)   Vol. 29 ( 1 ) page: 164 - 173   2022.1

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    PURPOSE: The purpose of the study is to evaluate the associations between intratumoral or peritumoral textural features derived from pretreatment magnetic resonance imaging (MRI) and recurrence-free survival (RFS) in triple-negative breast cancer (TNBC) patients. METHODS: Forty-three patients with TNBC who underwent preoperative MRI between February 2008 and March 2014 were included. We performed two-dimensional texture analysis on the intratumoral or peritumoral region of interest (ROI) on axial of T2-weighted image (T2WI), dynamic contrast-enhanced (DCE)-MRI and DCE-MRI subtraction images. We also analyzed histopathological data. Cox proportional hazards models were used to investigate associations with survival outcomes. RESULTS: Twelve of the 43 patients (27.9%) had recurrence disease, at a median of 32.5 months follow-up (1.4-61.5 months). In univariate analysis, nine texture features in T2WI and DCE-MRI subtraction images were significantly associated with RFS. In multivariate analysis, intratumoral difference entropy in DCE-MRI subtraction images in the initial phase (hazard ratio 11.71; 95% confidence interval (CI) [1.41, 97.00]; p value 0.023) and, peritumoral difference variance in DCE-MRI subtraction images in the delayed phase (hazard ratio 9.60; 95% CI [1.98, 46.51]; p value 0.005), were both independently associated with RFS. Moreover, multivariate analysis revealed the presence of lymphovascular invasion as independently associated with RFS (hazard ratio 8.13; 95% CI [2.16, 30.30]; p value 0.002). CONCLUSIONS: At pretreatment MRI, an intratumoral and peritumoral quantitative approach using texture analysis has the potential to serve as a prognostic marker in patients with TNBC.

    DOI: 10.1007/s12282-021-01294-1

    DOI: 10.1007/s12282-021-01294-1

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  22. Incidental findings on computed tomography for preoperative assessment before transcatheter aortic valve implantation in Japanese patients. Reviewed

    Akihiro Tobe, Akihito Tanaka, Yoshiyuki Tokuda, Yusuke Miki, Kenji Furusawa, Sho Akita, Taro Fujii, Yoshinori Tsutsumi, Hideki Ishii, Shingo Iwano, Shinji Naganawa, Akihiko Usui, Toyoaki Murohara

    Heart and vessels   Vol. 36 ( 12 ) page: 1911 - 1922   2021.12

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    Extra-cardiovascular incidental findings (IFs) on preoperative computed tomography (CT) are frequently observed in transcatheter aortic valve implantation (TAVI) candidates. However, the backgrounds of TAVI candidates and comorbidities differ based on the race and/or country, and data on IFs in a specific population are not always applicable to another. The aim of this study was to assess the prevalence, type, and clinical impact of IFs in Japanese TAVI candidates. This was a retrospective, single-center, observational study. CT reports of 257 TAVI candidates were reviewed, and IFs were classified as (a) insignificant: findings that did not require further investigation, treatment, or follow-up; (b) intermediate: findings that needed to be followed up or were considered for further investigation but did not affect the planning of TAVI; and (c) significant: findings that required further investigation immediately or affected the planning of TAVI. At least one IF was found in 254 patients (98.8%). Insignificant, intermediate, and significant IFs were found in 253 (98.4%), 153 (59.5%), and 34 (13.2%) patients, respectively. Newly indicated significant IFs were found in 19 patients (7.4%). In 2 patients (0.8%), TAVI was canceled because of significant IFs. In patients who consequently underwent TAVI, the presence of significant IFs was not associated with the duration from CT performance to TAVI [28 (19-40) days vs. 27 (19-43) days, p = 0.74] and all-cause mortality during the median follow-up period of 413 (223-805) days (p = 0.44). Almost all Japanese TAVI candidates had at least one IF, and the prevalence of significant IFs was not negligible. Although the presence of significant IFs was not associated with mid-term mortality, appropriate management of IFs was considered important.

    DOI: 10.1007/s00380-021-01875-2

    DOI: 10.1007/s00380-021-01875-2

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  23. Diagnostic utility of metabolic parameters on FDG PET/CT for lymph node metastasis in patients with cN2 non-small cell lung cancer. Reviewed International journal

    Keita Nakanishi, Shota Nakamura, Tomoshi Sugiyama, Yuka Kadomatsu, Harushi Ueno, Masaki Goto, Naoki Ozeki, Takayuki Fukui, Shingo Iwano, Toyofumi Fengshi Chen-Yoshikawa

    BMC cancer   Vol. 21 ( 1 ) page: 983 - 983   2021.9

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    BACKGROUND: The aim of this study was to assess the diagnostic utility of metabolic parameters on fluorine-18-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/computed tomography (CT) for predicting lymph node (LN) metastasis in patients with cN2 non-small cell lung cancer (NSCLC). METHODS: We retrospectively reviewed patients who underwent surgery for cN2 NSCLC between 2007 and 2020. Those who had clinically diagnosed positive hilar and mediastinal LNs by routine CT and PET/CT imaging were investigated. To measure the metabolic parameters of LNs, the data according to maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and LN-to-primary tumor ratio of SUVmax (LPR) were examined. The diagnosis of each retrieved LN was confirmed based on histopathological examination of surgical tissue specimens. Receiver operating characteristics (ROC) curves with area under the curve (AUC) calculations and multivariate analysis by logistic regression were performed. RESULTS: Forty-five patients with 84 clinically diagnosed positive hilar or mediastinal LNs were enrolled in the present study. Of the 84 LNs, 63 LNs were pathologically proven as positive (75%). The SUVmax, MTV, TLG, and LPR of LN metastasis were significantly higher than those of benign nodes. In the ROC analysis, the AUC value of LPR [AUC, 0.776; 95% confidence interval (CI), 0.640-0.913] was higher than that of LN SUVmax (AUC, 0.753; 95% CI, 0.626-0.880) or LN TLG3.5 (AUC, 0.746; 95% CI, 0.607-0.885). Using the optimal LPR cutoff value of 0.47, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 84.1, 66.7, 88.3, 58.3, and 79.8%, respectively. Multivariate analysis by logistic regression showed that LPR was an independent predictor for LN metastasis (odds ratio, 6.45; 95% CI, 1.785-23.301; P = 0.004). In the subgroup analysis of adenocarcinoma patients (n = 18; 32 LNs), TLG3.5 was a better predictor (AUC, 0.816; 95% CI, 0.639-0.985) than LPR (AUC, 0.792; 95% CI, 0.599-0.986) or LN SUVmax (AUC, 0.792; 95% CI, 0.625-0.959). CONCLUSIONS: Our findings suggest that LPR on FDG-PET is a useful predictor for LN metastasis in patients with cN2 NSCLC. TLG can be a good predictor for LN metastasis in patients with adenocarcinoma.

    DOI: 10.1186/s12885-021-08688-6

    DOI: 10.1186/s12885-021-08688-6

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  24. 【COVID-19肺炎と肺疾患AI開発のフロントライン】COVID-19肺炎におけるAI研究の動向および問題点について

    伊藤 倫太郎, 岩野 信吾, 長縄 慎二

    医用画像情報学会雑誌   Vol. 38 ( 2 ) page: 32 - 40   2021.7

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    Language:Japanese   Publisher:医用画像情報学会  

    COVID-19が世界中に広まり、COVID-19肺炎の診断に胸部CTや胸部単純X線の有用性が報告され、この画像所見を用いたAI開発が初期の段階から積極的に行われた。高性能なAIが多数存在するが、臨床において用いる際には注意すべき点が複数存在する。COVID-19肺炎に対して開発・使用された画像診断に関連するAI研究について、PubMedに2020年12月までに登録されたものを抽出しレビューを行った。

  25. cN2非小細胞肺癌のリンパ節転移に対するFDG PET/CTでの代謝パラメーターの診断的有用性に関する検討

    仲西 慶太, 矢澤 まり, 坪内 秀樹, 杉山 燈人, 門松 由佳, 上野 陽史, 後藤 真輝, 尾関 直樹, 中村 彰太, 福井 高幸, 岩野 信吾, 芳川 豊史

    日本外科学会定期学術集会抄録集   Vol. 121回   page: PS - 8   2021.4

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    Language:Japanese   Publisher:(一社)日本外科学会  

  26. Factors associated with changes in the 12-m stair-climbing time after lung lobectomy. Reviewed

    Naoki Ozeki, Takayuki Fukui, Shingo Iwano, Shuhei Hakiri, Shota Nakamura, Koji Kawaguchi, Yota Mizuno, Takayuki Inoue, Motoki Nagaya, Toyofumi Fengshi Chen-Yoshikawa

    General thoracic and cardiovascular surgery   Vol. 69 ( 2 ) page: 282 - 289   2021.2

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    OBJECTIVE: Postoperative loss-of-exercise capacity is one of the main concerns for patients undergoing lung cancer surgery. This study was designed to identify the factors associated with loss-of-exercise capacity after lobectomy, using an easy surrogate measure: the 12-m stair-climbing time (SCt). METHODS: Ninety-eight patients undergoing lobectomy for suspected stage I lung cancer were prospectively enrolled. SCt and pulmonary function test were evaluated preoperatively as baseline and at 6 months postoperatively. At 6 months postoperatively, 20 patients dropped out. Loss-of-exercise capacity was defined as at least a 3.3% decline (lower quartile) in the estimated maximal oxygen uptake (VO2t: 43.06 - 0.4 × SCt). Factors associated with loss-of-exercise capacity were analyzed. RESULTS: Median (interquartile range) baseline SCt was 31.5 (28.2-36.7) s. Baseline SCt was not significantly associated with complications. At 6 months postoperatively, SCt increased by + 4.4 (+ 3.2, + 6.8) s in patients with loss-of-exercise capacity. Sex, smoking status, lobe, procedure, and forced expiratory volume in 1 s showed no significant association with loss-of-exercise capacity. In the multivariable logistic regression, older age (≥ 73 years) (odds ratio: 5.25, 95% confidence interval: 1.50-18.43, p = 0.010) and lower baseline diffusing capacity of the lung for carbon monoxide (< 75%) (odds ratio: 9.23, 95% confidence interval: 1.94-43.93, p = 0.005) were significantly associated with loss-of-exercise capacity. CONCLUSION: Age and the baseline diffusing capacity of the lung for carbon monoxide were identified as significant variables associated with variation of exercise capacity after lung cancer surgery, using pre- and postoperative SCt.

    DOI: 10.1007/s11748-020-01458-4

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  27. Iodine-related attenuation in contrast-enhanced dual-energy computed tomography in small-sized solid-type lung cancers is associated with the postoperative prognosis. Reviewed International journal

    Shingo Iwano, Shinichiro Kamiya, Rintaro Ito, Shota Nakamura, Shinji Naganawa

    Cancer imaging : the official publication of the International Cancer Imaging Society   Vol. 21 ( 1 ) page: 7 - 7   2021.1

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    BACKGROUND: To investigate the correlation between iodine-related attenuation in contrast-enhanced dual-energy computed tomography (DE-CT) and the postoperative prognosis of surgically resected solid-type small-sized lung cancers. METHODS: We retrospectively reviewed the DE-CT findings and postoperative course of solid-type lung cancers ≤3 cm in diameter. After injection of iodinated contrast media, arterial phases were scanned using 140-kVp and 80-kVp tube voltages. Three-dimensional iodine-related attenuation (3D-IRA) of primary tumors at the arterial phase was computed using the "lung nodule" application software. The corrected 3D-IRA normalized to the patient's body weight and contrast medium concentration was then calculated. RESULTS: A total of 120 resected solid-type lung cancers ≤3 cm in diameter were selected for analysis (82 males and 38 females; mean age, 67 years). During the observation period (median, 47 months), 32 patients showed postoperative recurrence. Recurrent tumors had significantly lower 3D-IRA and corrected 3D-IRA at early phase compared to non-recurrent tumors (p = 0.046 and p = 0.027, respectively). The area under the receiver operating characteristic curve for postoperative recurrence was 0.624 for the corrected 3D-IRA at early phase (p = 0.025), and the cutoff value was 5.88. Kaplan-Meier curves for disease-free survival indicated that patients showing tumors with 3D-IRA > 5.88 had a significantly better prognosis than those with tumors showing 3D-IRA < 5.88 (p = 0.017). CONCLUSIONS: The 3D-IRA of small-sized solid-type lung cancers on contrast-enhanced DE-CT was significantly associated with postoperative prognosis, and low 3D-IRA tumors showed a higher TNM stage and a significantly poorer prognosis.

    DOI: 10.1186/s40644-020-00368-1

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  28. A review on the use of artificial intelligence for medical imaging of the lungs of patients with coronavirus disease 2019. International journal

    Rintaro Ito, Shingo Iwano, Shinji Naganawa

    Diagnostic and interventional radiology (Ankara, Turkey)   Vol. 26 ( 5 ) page: 443 - 448   2020.9

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    The results of research on the use of artificial intelligence (AI) for medical imaging of the lungs of patients with coronavirus disease 2019 (COVID-19) has been published in various forms. In this study, we reviewed the AI for diagnostic imaging of COVID-19 pneumonia. PubMed, arXiv, medRxiv, and Google scholar were used to search for AI studies. There were 15 studies of COVID-19 that used AI for medical imaging. Of these, 11 studies used AI for computed tomography (CT) and 4 used AI for chest radiography. Eight studies presented independent test data, 5 used disclosed data, and 4 disclosed the AI source codes. The number of datasets ranged from 106 to 5941, with sensitivities ranging from 0.67-1.00 and specificities ranging from 0.81-1.00 for prediction of COVID-19 pneumonia. Four studies with independent test datasets showed a breakdown of the data ratio and reported prediction of COVID-19 pneumonia with sensitivity, specificity, and area under the curve (AUC). These 4 studies showed very high sensitivity, specificity, and AUC, in the range of 0.9-0.98, 0.91-0.96, and 0.96-0.99, respectively.

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  29. Assessment of Severity in Chronic Thromboembolic Pulmonary Hypertension by Quantitative Parameters of Dual-Energy Computed Tomography. International journal

    Yoshinori Tsutsumi, Shingo Iwano, Naoki Okumura, Shiro Adachi, Shinji Abe, Takahisa Kondo, Katsuhiko Kato, Shinji Naganawa

    Journal of computer assisted tomography   Vol. 44 ( 4 ) page: 578 - 585   2020.7

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    OBJECTIVE: The objective of this study was to assess the correlation between dual-energy computed tomography quantitative parameters and hemodynamics in patients with chronic thromboembolic pulmonary hypertension. METHODS: Dual-energy computed tomography of 52 chronic thromboembolic pulmonary hypertension patients were evaluated retrospectively. The mean lung perfused blood volume (lung PBV) and the mean pulmonary artery (PA) enhancement measured at pulmonary parenchymal phase were compared with the hemodynamics by Spearman rank correlation coefficient (rs) and receiver operating characteristic analysis. RESULTS: Lung PBV was correlated with mean pulmonary arterial pressure (rs = 0.47, P < 0.001). Pulmonary artery enhancement was correlated with cardiac index (rs = -0.49, P < 0.001) and pulmonary vascular resistance (rs = 0.48, P < 0.001). The areas under the curves were 0.86 for lung PBV to predict mean pulmonary arterial pressure of >50 mm Hg and 0.86 for PA enhancement to predict pulmonary vascular resistance of >1000 dyne·s/cm. CONCLUSIONS: Lung PBV and PA enhancement could be indicators of hemodynamics.

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  30. Well-differentiated fetal adenocarcinoma of the lung: positron emission tomography features and diagnostic difficulties in frozen section analysis-a case report. International journal

    Shuhei Hakiri, Takayuki Fukui, Hideki Tsubouchi, Ayako Sakakibara, Shingo Iwano, Toyofumi F Chen-Yoshikawa

    Surgical case reports   Vol. 6 ( 1 ) page: 152 - 152   2020.6

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    BACKGROUND: Well-differentiated fetal adenocarcinoma (WDFA) of the lung is a rare disease that resembles fetal lung tubules. Most of previous reports concerning WDFA have focused on histological features, while there are few reports describing radiological features. In addition, there are no reports evaluating the difficulty of intraoperative diagnosis of WDFA with frozen section. We report a case of WDFA and review the radiological features of WDFA including the findings of F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and assess the difficulty of intraoperative diagnosis with frozen section. CASE PRESENTATION: A chest radiography performed in a 20-year-old female revealed a mass in the hilum of the right lung. Computed tomography revealed a well-defined mass measuring 3.5 × 3.0 cm in diameter in the right upper lobe, whereas PET showed a high accumulation of FDG. The most likely diagnosis was clinical T2aN0M0 stage 1B non-small cell lung cancer. A right S3 segmentectomy was performed via thoracotomy, and a benign tumor that was possibly an adenoma was intraoperatively diagnosed based on frozen section analysis. The mass was a solid tumor measuring 2.9 × 2.5 cm in diameter. Microscopically, the tumor comprised abundant glands with single or double layers of nonciliated cells and bronchial structures resembling a fetal lung. Rounded morules of polygonal cells were frequently observed. Immunohistochemistry revealed that nuclei and cytoplasm of the tumor cell were positive for β-catenin. Finally, the postoperative pathological diagnosis was well-differentiated fetal adenocarcinoma of the lung, and completion right upper lobectomy and mediastinal lymph node dissection were conducted 1 month after the initial segmentectomy. No residual tumor or lymph node metastasis was identified, and the final pathological stage was pT1cN0M0 stage 1A3. The patient did not wish to receive any adjuvant therapy. At the 1-year follow-up, no evidence of recurrence was noted. CONCLUSIONS: Here, we report a rare case of well-differentiated fetal adenocarcinoma of the lung that was difficult to diagnose based on radiological evaluations including FDG-PET and intraoperative diagnosis using frozen section analysis.

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  31. Psoas muscle mass in patients undergoing lung cancer surgery: a prognostic difference between squamous cell carcinoma and adenocarcinoma Reviewed

    Naoki Ozeki, Koji Kawaguchi, Takayuki Fukui, Shota Nakamura, Shuhei Hakiri, Shunsuke Mori, Masaki Goto, Shingo Iwano, Kohei Yokoi, Toyofumi Fengshi Chen-Yoshikawa

    International Journal of Clinical Oncology   Vol. 25 ( 5 ) page: 876 - 884   2020.5

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    © 2020, Japan Society of Clinical Oncology. Background: Psoas muscle mass is a surrogate marker for sarcopenia: a depletion of skeletal muscle mass. This study was conducted to elucidate the prognostic significance of the psoas muscle index (PMI: cross-sectional area of the bilateral psoas muscle at the umbilical level on computed tomography/height2 [cm2/m2]) in patients undergoing surgery for lung squamous cell carcinoma (SCC) and lung adenocarcinoma (ADC). Methods: One hundred and sixty-five patients with SCC and 556 patients with ADC who underwent R0 resection between 2007 and 2014 were reviewed for analysis. In SCC patients, the mean value (standard deviation) of the PMI was 6.15 (1.49) in men and 4.65 (1.36) in women. Among ADC patients, the PMI was 7.12 (1.60) in men and 5.29 (1.22) in women. Clinicopathological characteristics as well as the survival were evaluated. Results: The PMI was associated with the age, body mass index (BMI), and serum albumin. In the multivariable Cox regression analysis, after adjusting for age, BMI, serum albumin, sex, pathological stage, and diffusing capacity for carbon monoxide, the PMI showed a significant association with the overall survival (OS) and disease-free survival (DFS) in SCC patients (hazard ratios 0.50 and 0.56, 95% confidence intervals 0.39–0.65 and 0.45–0.71, respectively). On the other hand, in ADC patients, the PMI had no impact on the OS or DFS. Conclusions: The PMI was significantly associated with the survival of lung SCC patients, but not of lung ADC patients, suggesting the presence of a previously unidentified relationship between skeletal muscle and lung SCC progression.

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  32. Unexpected radioactive iodine accumulation on whole-body scan after I-131 ablation therapy for differentiated thyroid cancer.

    Shingo Iwano, Shinji Ito, Shinichiro Kamiya, Rintaro Ito, Katsuhiko Kato, Shinji Naganawa

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 205 - 215   2020.5

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    We retrospectively evaluated the frequency of unexpected accumulation of radioactive iodine on the post-therapy whole-body scan (Rx-WBS) after radioactive iodine (RAI) ablation therapy in patients with differentiated thyroid cancer (DTC). We searched our institutional database for Rx-WBSs of DTC patients who underwent RAI ablation or adjuvant therapy between 2012 and 2019. Patients with distant metastasis diagnosed by CT or PET/CT before therapy, and those had previously received RAI therapy were excluded. In total, 293 patients (201 female and 92 male, median age 54 years) were selected. Two nuclear medicine physicians interpreted the Rx-WBS images by determining the visual intensity of radioiodine uptake by the thyroid bed, cervical and mediastinal lymph nodes, lungs, and bone. Clinical features of the patients with and without the metastatic accumulation were compared by chi-square test and median test. Logistic regression analyses were performed to compare the association between the presence of metastatic accumulation and these clinical factors. Eighty-four of 293 patients (28.7%) showed metastatic accumulation. Patients with metastatic RAI accumulation showed a significantly higher frequency of pathological N1 (pN1) and serum thyroglobulin (Tg) > 1.5 ng/ml under TSH stimulation (p = 0.035 and p = 0.031, respectively). Logistic regression analysis indicated that a serum Tg > 1.5 ng/ml was significantly correlated with the presence of metastatic accumulation (odds ratio = 1.985; p = 0.033). In conclusion, Patients with Tg > 1.5 ng/ml were more likely to show metastatic accumulation. In addition, the presence of lymph node metastasis at the initial thyroid surgery was also associated with this unexpected metastatic accumulation.

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  33. Reply to "Prognostic Impact and Risk Factors of Immune-Related Pneumonitis in Patients With Non-Small-Cell Lung Cancer Who Received Programmed Death-1 Inhibitors". International journal

    Jun Fukihara, Koji Sakamoto, Junji Koyama, Takayasu Ito, Shingo Iwano, Masahiro Morise, Masahiro Ogawa, Yasuhiro Kondoh, Tomoki Kimura, Naozumi Hashimoto, Yoshinori Hasegawa

    Clinical lung cancer   Vol. 21 ( 3 ) page: E205 - E205   2020.5

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  34. 病期Iの肺癌切除症例の術後再発における残存慢性呼吸器疾患の影響に関する検討

    橋本 直純, 川口 晃司, 岩野 信吾

    肺癌   Vol. 60 ( 2 ) page: 143 - 143   2020.4

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  35. 【基礎から学ぶ肺癌診断】肺癌の3次元CT・PET/CT診断 原発巣の診断と悪性度

    岩野 信吾, 伊藤 信嗣, 伊藤 倫太郎, 神谷 晋一朗, 加藤 克彦, 長縄 慎二

    画像診断   Vol. 40 ( 5 ) page: 439 - 446   2020.3

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    <文献概要>肺癌の臨床病期分類(TNM分類)は主に画像診断に基づいて行われる.2017年に改訂されたTNM分類では,T因子(サイズ)の診断が複雑になった.病理学的浸潤径に相当する充実成分径の計測はthinsection CTで行うのが基本であるが,3次元CTやPET/CTを利用することで精度の向上が期待できる.

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  36. Micro-computed tomography images of lung adenocarcinoma: Detection of lepidic growth patterns Reviewed

    Shota Nakamura, Kensaku Mori, Shingo Iwano, Koji Kawaguchi, Takayuki Fukui, Shuhei Hakiri, Naoki Ozeki, Masahiro Oda, Kohei Yokoi

    Nagoya Journal of Medical Science   Vol. 82 ( 1 ) page: 25 - 31   2020.2

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    © 2020 Nagoya University. Micro-computed tomography (μCT) provides extremely high-resolution images of samples and can be employed as a non-destructive inspection tool. Using μCT, we can obtain images comparable with microscopic images. In this work, we have attempted to take high-resolution images of the human lung using μCT. Compared to clinical high-resolution computed tomography (HRCT) images of living body (in-vivo imaging), we can obtain extremely high-resolution images by μCT of ex-vivo tissues (resected lungs) as three-dimensional data. The purpose of this study was to distinguish between areas of normal lung and lung cancer by μCT images in order to study the feasibility of cancer diagnosis using this novel radiological image modality. Ten resected human lungs containing primary cancer were fixed by Heitzman's methods to obtain high-resolution μCT images. After fixation of the lung, images of the specimens were taken by μCT between January 2016 and November 2017. The imaging conditions were tube voltage: 90 kV and tube current: 110 μA. To compare details of images gained by conventional HRCT and μCT, we measured the thickness of the alveolar walls of the normal lung area and the cancer area of which alveoli might be replaced by tumor cells, and compared their appearance by means of histopathological images. All the nodules were diagnosed as adenocarcinoma. The median whole tumor size was 18 mm (9 mm-24 mm). Each specimen was clearly divided into areas of normal alveolar wall and of thickened alveolar wall on μCT 'visually'. Median thickness of alveolar walls of the normal lung was 0.037 mm (0.034 mm-0.048 mm), and that of the cancer area was 0.084 mm (0.074 mm-0.094 mm); there was a statistically significant difference between both thicknesses by Student's t-test (P < 0.01). The area of thickened alveolar walls on μCT corresponded well with the area of microscopically lepidic growth patterns of adenocarcinoma. We found that μCT images could be correctly divided by alveolar walls into normal lung area and lung cancer area. Further detailed investigations with regard to μCT are needed to make comparable histological diagnoses using μCT images with conventional microscopic methods of pathological diagnoses.

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  37. 中枢神経系原発anaplastic lymphoma kinase陽性未分化大細胞リンパ腫の1例

    佐々木 裕太郎, 中道 玲瑛, 伊藤 信嗣, 川井 恒, 岩野 信吾, 田岡 俊昭, 加藤 克彦, 川島 直美, 下山 芳江, 長縄 慎二

    映像情報Medical   Vol. 52 ( 1 ) page: 82 - 83   2020.1

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  38. Kinetic volume analysis on dynamic contrast-enhanced MRI of triple-negative breast cancer: associations with survival outcomes. Reviewed International journal

    Yoko Hayashi, Hiroko Satake, Satoko Ishigaki, Rintaro Ito, Mariko Kawamura, Hisashi Kawai, Shingo Iwano, Shinji Naganawa

    The British journal of radiology   Vol. 93 ( 1106 ) page: 20190712 - 20190712   2020

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    OBJECTIVE: To evaluate the associations between computer-aided diagnosis (CAD)-generated kinetic volume parameters and survival in triple-negative breast cancer (TNBC) patients. METHODS: 40 patients with TNBC who underwent pre-operative MRI between March 2008 and March 2014 were included. We analyzed CAD-generated parameters on dynamic contrast-enhanced MRI, visual MRI assessment, and histopathological data. Cox proportional hazards models were used to determine associations with survival outcomes. RESULTS: 12 of the 40 (30.0%) patients experienced recurrence and 7 died of breast cancer after a median follow-up of 73.6 months. In multivariate analysis, higher percentage volume (%V) with more than 200% initial enhancement rate correlated with worse disease-specific survival (hazard ratio, 1.12; 95% confidence interval, 1.02-1.22; p-value, 0.014) and higher %V with more than 100% initial enhancement rate followed by persistent curve type at 30% threshold correlated with worse disease-specific survival (hazard ratio, 1.33; 95% confidence interval, 1.10-1.61; p-value, 0.004) and disease-free survival (hazard ratio, 1.27; 95% confidence interval, 1.12-1.43; p-value, 0.000). CONCLUSION: CAD-generated kinetic volume parameters may correlate with survival in TNBC patients. Further study would be necessary to validate our results on larger cohorts. ADVANCES IN KNOWLEDGE: CAD generated kinetic volume parameters on breast MRI can predict recurrence and survival outcome of patients in TNBC. Varying the enhancement threshold improved the predictive performance of CAD generated kinetic volume parameter.

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  39. Prognostic Impact and Risk Factors of Immune-Related Pneumonitis in Patients With Non-Small-Cell Lung Cancer Who Received Programmed Death 1 Inhibitors. International journal

    Jun Fukihara, Koji Sakamoto, Junji Koyama, Takayasu Ito, Shingo Iwano, Masahiro Morise, Masahiro Ogawa, Yasuhiro Kondoh, Tomoki Kimura, Naozumi Hashimoto, Yoshinori Hasegawa

    Clinical lung cancer   Vol. 20 ( 6 ) page: 442 - +   2019.11

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    INTRODUCTION: Pneumonitis is one of the immune-related adverse events of programmed death 1 (PD-1) inhibitors that sometimes cause lethal outcomes. Although some recent reports have described PD-1 inhibitors as more effective in non-small-cell lung cancer (NSCLC) patients with immune-related adverse events than in those without, few data are available on the prognosis of those treated with PD-1 inhibitors who developed immune-related pneumonitis (IRP). Additionally, the robust risk factors of IRP have not been well elucidated. PATIENTS AND METHODS: A retrospective review of patients with recurrent or advanced NSCLC who took a PD-1 inhibitor (nivolumab or pembrolizumab monotherapy) between January 2016 and March 2018 was undertaken. Radiologic findings such as unilateral infiltration were also defined as IRP as long as they were deemed relevant to PD-1 inhibitors. RESULTS: Twenty-seven (16%) of 170 patients developed IRP. Although 22 (81%) of 27 patients with IRP recovered with drug cessation with or without corticosteroid therapy, 8-week landmark analysis showed the overall survival after administration of the PD-1 inhibitor was significantly shorter in patients with IRP than in those without (8.7 vs. 23.0 months, P = .015). Patients with IRP tended to not receive next-line treatment and choose best supportive care after cessation of PD-1 inhibitor therapy. In the multivariate analysis, pembrolizumab (vs. nivolumab) and low serum albumin were independent risk factors for IRP. CONCLUSION: Development of IRP was correlated with poor prognosis in patients with NSCLC. Further study is necessary for establishing the best prediction and management strategies for IRP.

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  40. ディープラーニングを用いた胸部CT像中の肺結節の画像所見の検出および良悪性鑑別

    福嶋 一茂, 平野 靖, 木戸 尚治, 岩野 信吾

    MEDICAL IMAGING TECHNOLOGY   Vol. 37 ( 5 ) page: 244 - 253   2019.11

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    近年、コンピューター診断支援(computer-aided diagnosis;CADx)システムに関する研究では、ディープラーニングが使用される機会が多くなってきており、従来よりも高い性能を示すことが報告されている。肺結節の良悪性鑑別のためのCADxシステムでも同様の傾向があるが、それらはCT像などを入力とし、良性あるいは悪性の尤度のみを出力するか、クラス分類するものが一般的である。一方で、患者に対して医師が肺結節の診断結果を説明する際には、良悪性の尤度だけでは不十分であり、診断結果の根拠を説明することが求められる。そこで本研究ではディープラーニングの一形態であるCNN(convolutional neural network)を用いて、CT像中の肺結節が悪性であることを示唆する画像所見の存在の尤度を診断の根拠として提供し、さらにそれらの尤度を入力するNN(neural network)によって良悪性の鑑別結果を医師に提供するCADxシステムの構築を行った。55個の良性結節と120個の悪性結節を用いて本手法の性能を評価した結果、識別率は79.02±8.43[%]となった。(著者抄録)

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  41. Multi-window levels and widths imaging 画像変換による新たな読影手法の検討

    伊藤 倫太郎, 岩野 信吾, 小田 紘久, 森 健策, 長縄 慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 55回   page: S531 - S532   2019.9

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  42. <Editors' Choice> Renewed Japanese spirometric reference variables and risk stratification for postoperative outcomes in COPD patients with resected lung cancer.

    Yu Okada, Naozumi Hashimoto, Shingo Iwano, Koji Kawaguchi, Takayuki Fukui, Koji Sakamoto, Kenji Wakai, Kohei Yokoi, Yoshinori Hasegawa

    Nagoya journal of medical science   Vol. 81 ( 3 ) page: 427 - 438   2019.8

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    Although the lower limit of normal (LLN) of FEV1/FVC detects at-risk patients for postoperative outcomes among Japanese chronic obstructive pulmonary disease (COPD) patients with resected lung cancer, there was a lack of a Japanese reference equation to calculate the LLN of FEV1/FVC. Renewed Japanese spirometric reference variables might enable us to verify clinical impact of the LLN of FEV1/FVC among the Japanese population. To evaluate the clinical impact of the LLN of FEV1/FVC by using this renewed reference, data were retrospectively analyzed from 609 newly diagnosed lung cancer patients who had undergone thoracic surgery between 2006 and 2011. The combined assessment of the 0.70 fixed ratio and the LLN of the FEV1/FVC ratio classified the 609 subjects into the COPD (214 subjects), non-COPD (337 subjects), and in-between (58 subjects) groups, respectively. All of the relative odds ratios (ORs) of postoperative outcomes for the comparison between the in-between and non-COPD groups did not show significant confidence intervals (CIs). On the other hand, the adjusted ORs of postoperative outcomes for the COPD group versus the non-COPD group were 2.840 (95% CI: 1.824-4.421) for prolonged oxygen therapy (POT), 1.836 (95% CI: 1.166-2.890) for prolonged postoperative stays, and 1.637 (95% CI: 1.007-2.663) for combined complications. Adjusted comparisons of POT between the in-between and COPD groups also showed a significant relative OR of 2.984 (95% CI: 1.447-6.153). A standardized assessment of the LLN of FEV1/FVC by a renewed Japanese spirometric reference provides risk stratification for postoperative outcomes in the population.

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  43. Utility of Metabolic Parameters on FDG PET/CT in the Classification of Early-Stage Lung Adenocarcinoma: Prediction of Pathological Invasive Size. Reviewed International journal

    Shingo Iwano, Shinji Ito, Shinichiro Kamiya, Rintaro Ito, Katsuhiko Kato, Shinji Naganawa

    Clinical nuclear medicine   Vol. 44 ( 7 ) page: 560 - 565   2019.7

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    PURPOSE: This paper aims to explore the role of a metabolic parameter on F-FDG-PET/CT for clinical T-classification in early-stage adenocarcinoma. PATIENTS AND METHODS: One hundred six surgically resected pathological TNM stage (p-stage) 0/I lung adenocarcinomas were retrospectively reviewed. The solid size (SS) measured on thin-section CT and the pathological invasive size (IS) of tumors were recorded. The SUVmax and metabolic tumor volume with SUV ≥1.0 (MTV1.0) derived from PET/CT data were measured on a workstation, and the metabolic tumor diameter with SUV ≥1.0 (MTD1.0) was calculated automatically from MTV1.0. For the correlations between the IS and the SS, MTD1.0, or SUVmax, Pearson's correlation coefficients were compared using the Meng-Rosenthal-Rubin method. Additionally, the reproducibility between the clinical TNM stage (c-stage), based on the SS or MTD1.0, and the p-stage was analyzed using the kappa coefficient (k). RESULTS: For the correlations between the IS and the other parameters, Pearson correlation coefficient was 0.630 for the SS, 0.600 for the SUVmax, and 0.725 for MTD1.0. MTD1.0 correlated significantly and more strongly with the IS than the SS and the SUVmax did (P = 0.040, and P = 0.008, respectively). The reproducibility between p-stage and c-stage based on the SS was moderate (k = 0.529, P < 0.001), whereas that between p-stage and c-stage based on MTD1.0 was substantial (k = 0.676, P < 0.001). CONCLUSIONS: MTD1.0 on FDG-PET/CT was correlated significantly and more strongly with the pathological IS in lung adenocarcinomas than with the SS on thin-section CT. FDG-PET/CT could classify more precisely early-stage lung adenocarcinoma than the presently used T-classification based on thin-section CT findings.

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  44. 【人工知能が医療を変える!医療分野におけるAI研究開発最前線2019】領域別・画像診断におけるAI研究開発の最前線 胸部領域 胸部画像診断におけるAIと臨床研究について

    伊藤 倫太郎, 岩野 信吾, 長縄 慎二

    INNERVISION   Vol. 34 ( 7 ) page: 25 - 28   2019.6

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    2006年から始まった第三次AIブームによりAIの研究が加速度的に進み、現在ではスマートフォンのカメラや音声入力など身近なものに活用されている。放射線医学においては古くから人工知能(AI)を用いた研究が行われ、臨床にも応用されていた。最近では、さらに発展したAIを用いたCADの開発が盛んであり、世界中の研究者が開発を競っている。本稿では、加速度的に進歩するAIと放射線医学とのかかわりについて、主に胸部画像診断の観点から現在の状況と問題点についてまとめ、実際の研究例について提示する。(著者抄録)

  45. 画像診断と病理 食道平滑筋腫

    兵藤 良太, 岩野 信吾, 長縄 慎二, 宮田 一志, 島田 聡子

    画像診断   Vol. 39 ( 7 ) page: 662 - 663   2019.5

  46. Association between chest computed tomography findings and respiratory adverse events in rheumatoid arthritis patients undergoing long-term biological therapy. Reviewed

    Matsumoto T, Iwano S, Takahashi N, Asai S, Watanabe T, Asai N, Sobue Y, Ito S, Ishiguro N, Kojima T

    International journal of rheumatic diseases   Vol. 22 ( 4 ) page: 626 - 635   2019.4

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    DOI: 10.1111/1756-185X.13434

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  47. FDG-PET/CTの腫瘍代謝容積に基づいた肺腺癌の臨床病期診断の試み

    岩野 信吾, 伊藤 倫太郎, 長縄 慎二

    肺癌   Vol. 59 ( 2 ) page: 189 - 189   2019.4

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  48. Longitudinal changes in pulmonary function and respiratory impedance of rheumatoid arthritis Reviewed

    Isobe Y, Ito S, Matsuda T, Iwano S, Uchida A, Takahashi N, Kojima T, Wakahara K, Yamaguchi E, Hasegawa Y

    Respiratory Physiology Neurobiology   Vol. 261   page: 1 - 8   2019.3

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    DOI: 10.1016/j.resp.2018.12.008

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  49. Quantitative Follow-Up Assessment of Patients with Interstitial Lung Disease by 3D-Curved High-Resolution CT Imaging Parallel to the Chest Wall. Reviewed

    Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Keigo Nakamura, Shinji Naganawa

    Nagoya journal of medical science   Vol. 81 ( 1 ) page: 41 - 53   2019.2

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    We evaluated the progression of interstitial lung disease (ILD) by three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall and compare the results to pulmonary function test (PFT) results on a follow-up assessment. We reviewed the patients with ILD who underwent HRCT and concurrent PFTs at least twice from April 2008 to December 2014. Forty-five patients with ILD were enrolled. 3D-cHRCT images of the lung at various depths from the chest wall were reconstructed, and total area (TA), high-attenuation area (HAA) >-500 HU, and %HAA ([HAA/TA] × 100) were calculated. The TA, HAA, and %HAA ratios (follow-up to baseline) were assessed for use in the diagnosis of physiologically progressive ILD (defined as; forced vital capacity [FVC] ratio <0.9 or %diffusing capacity of the lung for carbon monoxide [%DLCO] ratio <0.85 [follow-up to baseline]). Of all ratios obtained from 3D-cHRCT images at 5-30mm depths, the %HAA ratio at 20-mm had the largest area under the receiver operating characteristic curve (0.815, 95 % confidence interval 0.677-0.953). By univariate logistic regression analysis, TA, HAA, and %HAA ratios at 20-mm showed significant correlations with physiologically progressive ILD. 3D-cHRCT imaging performed in parallel with the chest wall offers novel quantitative parameters that are useful for following ILD.

    DOI: 10.18999/nagjms.81.1.41

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  50. 原発性肺癌の術前臨床病期診断の正確性

    岩野 信吾, 馬越 弘泰, 伊藤 倫太郎, 島本 宏矩, 長縄 慎二

    Japanese Journal of Radiology   Vol. 37 ( Suppl. ) page: 25 - 25   2019.2

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  51. Effect of blood glucose level on standardized uptake value (SUV) in <sup>18</sup>F- FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements. Reviewed

    Eskian M, Alavi A, Khorasanizadeh M, Viglianti BL, Jacobsson H, Barwick TD, Meysamie A, Yi SK, Iwano S, Bybel B, Caobelli F, Lococo F, Gea J, Sancho-Muñoz A, Schildt J, Tatcı E, Lapa C, Keramida G, Peters M, Boktor RR, John J, Pitman AG, Mazurek T, Rezaei N

    European journal of nuclear medicine and molecular imaging   Vol. 46 ( 1 ) page: 224 - 237   2019.1

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    DOI: 10.1007/s00259-018-4194-x

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  52. Detection of Medical Image Findings and Discrimination between Benign and Malignant Nodules in Chest CT Images by Using Deep Learning

    FUKUSHIMA Kazushige, HIRANO Yasushi, KIDO Shoji, IWANO Shingo

    Medical Imaging Technology   Vol. 37 ( 5 ) page: 244 - 254   2019

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    <p>Computer-aided diagnosis (CADx) systems based on deep learning have been actively researched in recent years, and it has been reported to exhibit their high performance. The CADx systems for benign and malignant discrimination exhibit a similar tendency. They generally convert input medical images into likelihood of their benignancy and malignancy. On the other hand, when medical doctors explain the diagnosis to patients, they need to explain not only the likelihood of malignancy of the lung nodule but also basis of the diagnosis. In this paper, we proposed a CADx system which provides medical doctor with likelihood of the existence of the medical image finding related to lung cancer CNN (convolutional neural network) for obtaining the likelihood of the medical image findings, and NN (neural network) for obtaining the likelihood of the malignancy of the lung nodule. As a result of evaluating the performance of the proposed system using 55 benign and 120 malignant nodules, the discrimination rate was 79.02±8.43 [%].</p>

    DOI: 10.11409/mit.37.244

  53. Generative Adversarial Networkを用いた肺結節の画像生成について

    伊藤 倫太郎, 岩野 信吾, 長縄 慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 54回   page: S561 - S561   2018.9

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  54. Impact of Patient Age and Histological Type on Radioactive Iodine Avidity of Recurrent Lesions of Differentiated Thyroid Carcinoma Reviewed

    Kenichi Nakanishi, Toyone Kikumori, Noriyuki Miyajima, Yuko Takano, Sumiyo Noda, Dai Takeuchi, Shingo Iwano, Yasuhiro Kodera

    Clinical Nuclear Medicine   Vol. 43 ( 7 ) page: 482 - 485   2018.7

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    Background Age is a prognostic factor for recurrent differentiated thyroid carcinoma (DTC) and may be related to radioactive iodine (RAI) nonavidity. Indications for molecular-targeted drugs (MTDs) are currently limited to RAI-refractory DTC. Demonstrating refractoriness to RAI, mainly indicated by RAI nonavidity, may be a barrier to the introduction of MTDs for elderly patients. The present study was conducted to evaluate the impact of age and histological type on the RAI avidity of recurrent lesions of DTC. Methods Two hundred fifty-eight patients (189 patients with classic papillary thyroid carcinoma [cPTC], 8 patients with follicular variant of papillary thyroid carcinoma, and 61 patients with follicular thyroid carcinoma), who underwent their first RAI whole-body scanning for recurrent DTC at our institution between 2004 and 2013, were retrospectively studied. Radioactive iodine uptake was determined by visible uptake by metastatic lesion(s) in a diagnostic RAI-whole-body scan. Results The prevalence of RAI-avid lung metastases in cPTC indicated a significant, inverse correlation with age (&lt
    55 years, 36.2%
    ≥55 years, 3%
    P &lt
    0.001). By contrast, for follicular thyroid carcinoma, the prevalence of RAI avidity was not influenced by age. Similar tendencies were observed for lymph node metastases. Conclusions Radioactive iodine avidity by metastatic lesions of cPTC in elderly patients, especially those older than 55 years, was seldom demonstrated. Adherence to a strategy of restricting MTD administration after confirmation of RAI refractoriness should be revisited for elderly patients. A strategy of omitting RAI treatment should be taken into account when considering age and histological type.

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  55. Deep Learningを用いた胸部CT像中の肺結節の画像所見の検出および良悪性鑑別

    福嶋 一茂, 平野 靖, 木戸 尚治, 岩野 信吾

    日本医用画像工学会大会予稿集   Vol. 37回   page: 173 - 181   2018.7

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    近年、コンピュータ診断支援(Computer-Aided Diagnosis,CADx)システムに関する研究では、Deep Learningが使用される機会が多くなってきており、従来よりも高い性能を示すことが報告されている。肺結節の良悪性鑑別のためのCADxシステムでも同様の傾向があるが、それらはCT像等を入力とし、良性あるいは悪性の尤度のみを出力するか、クラス分類するものが一般的である。一方で患者に対して医師が肺結節の診断結果を説明する際には、良悪性の尤度だけでは不十分であり、診断結果の根拠を説明することが求められる。そこで本研究ではDeep Learningの一形態であるCNN(Convolutional Neural Network)を用いて、CT像中の肺結節が悪性であることを示唆する画像所見の存在の尤度を診断の根拠として提供し、さらにそれらの尤度を入力とするNN(Neural Network)によって良悪性の鑑別結果を医師に提供するCADxシステムの構築を行った。55個の良性結節と120個の悪性結節を用いて本手法の性能を評価した結果、識別率は79.02±8.43[%]となった。(著者抄録)

  56. Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer Reviewed

    Shinji Ito, Shingo Iwano, Katsuhiko Kato, Shinji Naganawa

    Annals of Nuclear Medicine   Vol. 32 ( 6 ) page: 418 - 424   2018.7

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    Objective: To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ablation (RAI) using a fixed low dose of I-131 (1110 MBq). Patients and methods: In this prospective study, we enrolled 45 patients. Patients were classified into a self-managed LID group and a strict LID group. We measured the urinary iodine concentration on the day of RAI after patients consumed LID for 2 weeks. Thyroid-stimulating hormone-induced thyroglobulin (Tg) levels and I-131 uptake by the remnant thyroid tissue were also evaluated. A response-evaluation whole-body scan (WBS) was performed 6–8 months after RAI to determine the outcome of the therapy. Results: Post-LID urinary iodine levels of the strict LID group tended to be lower than those of the self-managed LID group. Twenty-five cases (56%) showed absence of uptake, whereas 20 cases (44%) showed residual uptake on the response-evaluation WBS. There were no significant differences between “absence” and “residual” groups in urinary iodine concentrations and Tg levels (p = 0.253 and p = 0.234, respectively). However, significant differences were observed in I-131 uptake by the thyroid bed (p = 0.035). Conclusions: For patients following the current Japanese method of a 2-week LID, the urinary iodine concentration was not a predictive factor for the successful outcome of RAI. In contrast, low I-131 uptake by the thyroid bed, revealed by the scintigram after RAI, may serve as a favorable predictive factor.

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  57. Computer-aided Volumetry of Part-Solid Lung Cancers by Using CT: Solid Component Size Predicts Prognosis. Reviewed International journal

    Shinichiro Kamiya, Shingo Iwano, Hiroyasu Umakoshi, Rintaro Ito, Hironori Shimamoto, Shota Nakamura, Shinji Naganawa

    Radiology   Vol. 287 ( 3 ) page: 1030 - 1040   2018.6

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    Purpose To investigate the relationship between the postoperative prognosis of patients with part-solid non-small cell lung cancer and the solid component size acquired by using three-dimensional (3D) volumetry software on multidetector computed tomographic (CT) images. Materials and Methods A retrospective study by using preoperative multidetector CT data with 0.5-mm section thickness, clinical records, and pathologic reports of 96 patients with primary subsolid non-small cell lung cancer (47 men and 49 women; mean age ± standard deviation, 66 years ± 8) were reviewed. Two radiologists measured the two-dimensional (2D) maximal solid size of each nodule on an axial image (hereafter, 2D MSSA), the 3D maximal solid size on multiplanar reconstructed images (hereafter, 3D MSSMPR), and the 3D solid volume of greater than 0 HU (hereafter, 3D SV0HU) within each nodule. The correlations between the postoperative recurrence and the effects of clinical and pathologic characteristics, 2D MSSA, 3D MSSMPR, and 3D SV0HU as prognostic imaging biomarkers were assessed by using a Cox proportional hazards model. Results For the prediction of postoperative recurrence, the area under the receiver operating characteristics curve was 0.796 (95% confidence interval: 0.692, 0.900) for 2D MSSA, 0.776 (95% confidence interval: 0.667, 0.886) for 3D MSSMPR, and 0.835 (95% confidence interval: 0.749, 0.922) for 3D SV0HU. The optimal cutoff value for 3D SV0HU for predicting tumor recurrence was 0.54 cm3, with a sensitivity of 0.933 (95% confidence interval: 0.679, 0.998) and a specificity of 0.716 (95% confidence interval: 0.605, 0.811) for the recurrence. Significant predictive factors for disease-free survival were 3D SV0HU greater than or equal to 0.54 cm3 (hazard ratio, 6.61; P = .001) and lymphatic and/or vascular invasion derived from histopathologic analysis (hazard ratio, 2.96; P = .040). Conclusion The measurement of 3D SV0HU predicted the postoperative prognosis of patients with part-solid lung cancer more accurately than did 2D MSSA and 3D MSSMPR. © RSNA, 2018.

    DOI: 10.1148/radiol.2018172319

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  58. 胸壁並行断面CTを用いた間質性肺炎の経時的評価

    馬越 弘泰, 岩野 信吾, 伊藤 倫太郎, 島本 宏矩, 長縄 慎二

    Japanese Journal of Radiology   Vol. 36 ( Suppl. ) page: 19 - 19   2018.2

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  59. 非小細胞肺癌の局所浸潤性の予測に関する造影dual energy CTとFDG-PET/CTの比較

    伊藤 倫太郎, 岩野 信吾, 島本 宏矩, 馬越 弘泰, 伊藤 信嗣, 長縄 慎二, 加藤 克彦

    Japanese Journal of Radiology   Vol. 36 ( Suppl. ) page: 20 - 20   2018.2

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  60. Thin-section computed tomography-determined usual interstitial pneumonia pattern affects the decision-making process for resection in newly diagnosed lung cancer patients: a retrospective study. Reviewed

    Hashimoto N, Ando A, Iwano S, Sakamoto K, Okachi S, Matsuzaki A, Okada Y, Wakai K, Yokoi K, Hasegawa Y

    BMC pulmonary medicine   Vol. 18 ( 1 ) page: 2   2018.1

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  61. FDG PET/CT Overcomes Discordance Between Clinical and Pathologic TNM Classification of Small-size Primary Lung Cancer: Influence on Postoperative Prognosis. Reviewed International journal

    Hiroyasu Umakoshi, Shingo Iwano, Kohei Yokoi, Shinji Ito, Rintaro Ito, Koji Kawaguchi, Takayuki Fukui, Shinji Naganawa

    Clinical lung cancer   Vol. 19 ( 1 ) page: E37 - E45   2018.1

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    INTRODUCTION: We aimed to determine the concordance between the clinical stage (c-stage) and pathologic stage (p-stage) for patients with small-size lung cancer. Additionally we searched for prognostic factors other than the TNM stage. PATIENTS AND METHODS: We retrospectively reviewed the preoperative multidetector computed tomography (CT) and positron emission tomography/CT reports, surgical records, and pathologic reports of patients with primary lung cancer ≤ 3 cm. The Union for International Cancer Control TNM seventh edition classification of c-stage and p-stage were compared. The tumors were classified into multiple subgroups by concordance or discordance between the c-stage and p-stage. Disease-free survival (DFS) was assessed using survival analysis to assess the tumor characteristics that were predictive of prognosis. RESULTS: A total of 289 surgically resected primary lung cancers were evaluated. The concordance between c-stage and p-stage was 65.4%, with moderate reproducibility (kappa coefficient, 0.467). The upstaging rate from c-stage I to p-stage II-IV was 9.4%, and these patients had significantly worse DFS than those with a concordant stage I classification (P < .001). The main reason for upstaging was an underestimation of metastases to the hilar lymph nodes (n = 7) or mediastinal lymph nodes (n = 11). A multivariate Cox proportional hazards model showed that the significant predictive factors for DFS were p-stage (hazard ratio, 1.342; P = .003) and maximum standardized uptake value on positron emission tomography/CT (hazard ratio, 12.162; P = .001). CONCLUSION: The concordance rate between c-stage and p-stage for small primary lung cancers had moderate reproducibility. Discordance between c-stage I and p-stage II-IV significantly affected DFS. The maximum standardized uptake value of the primary lesion was an independent prognostic factor, and combining it with c-stage might improve the prediction of therapeutic outcomes.

    DOI: 10.1016/j.cllc.2017.05.021

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  62. A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological invasiveness of non-small cell lung cancer. Reviewed International journal

    Rintaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    European journal of radiology   Vol. 95   page: 186 - 191   2017.10

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    PURPOSE: To compare dual-phase dual-energy CT (DE-CT) with FDG-PET/CT for predicting histopathological locoregional invasiveness of non-small cell lung cancers (NSCLCs). MATERIALS AND METHODS: We selected 63 consecutive patients with NSCLC lesions (37 males, 26 females; age range, 44-85 years; mean age, 69 years) who were evaluated preoperatively by both DE-CT and PET/CT at our institution. Postoperative microscopic invasiveness (lymphatic permeation, vascular invasion, and/or pleural involvement) was reviewed, and we defined locoregionally invasive tumors as those that had at least one positive finding of microscopic invasiveness. DE-CT scanning in the arterial and delayed phases was performed after injection of iodinated contrast media using 140-kVp and 80-kVp tube voltages. Three-dimensional iodine-related attenuation of primary tumors in the arterial and delayed phases was quantified automatically using "syngo Dual Energy Lung Nodules" application software, and the ratio of arterial phase to delayed phase enhancement (A/D ratio) was calculated. The A/D ratio and SUVmax on PET/CT were evaluated with respect to postoperative invasiveness by univariate logistic regression analysis. RESULTS: The A/D ratio was significantly correlated with lymphatic permeation, vascular invasion, and pleural involvement (p=0.011, p=0.021, and p=0.010, respectively). In contrast, the SUVmax was significantly correlated with pleural involvement (p=0.020) but not with lymphatic permeation or vascular invasion (p=0.088 and p=0.100, respectively). In the subgroup of patients with lesion diameters ≤2cm, the A/D ratio was significantly correlated with locoregional invasiveness (p=0.040), while the SUVmax was not (p=0.121). CONCLUSION: For the prediction of microscopic invasiveness of NSCLCs, the diagnostic performance of dual-phase DE-CT may be comparable to that of FDG-PET/CT.

    DOI: 10.1016/j.ejrad.2017.08.010

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  63. Automated mediastinal lymph node detection from CT volumes based on intensity targeted radial structure tensor analysis Reviewed

    Hirohisa Oda, Kanwal K. Bhatia, Masahiro Oda, Takayuki Kitasaka, Shingo Iwano, Hirotoshi Homma, Hirotsugu Takabatake, Masaki Mori, Hiroshi Natori, Julia A. Schnabel, Kensaku Mori

    Journal of Medical Imaging   Vol. 4 ( 4 ) page: 044502   2017.10

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    This paper presents a local intensity structure analysis based on an intensity targeted radial structure tensor (ITRST) and the blob-like structure enhancement filter based on it (ITRST filter) for the mediastinal lymph node detection algorithm from chest computed tomography (CT) volumes. Although the filter based on radial structure tensor analysis (RST filter) based on conventional RST analysis can be utilized to detect lymph nodes, some lymph nodes adjacent to regions with extremely high or low intensities cannot be detected. Therefore, we propose the ITRST filter, which integrates the prior knowledge on detection target intensity range into the RST filter. Our lymph node detection algorithm consists of two steps: (1) obtaining candidate regions using the ITRST filter and (2) removing false positives (FPs) using the support vector machine classifier. We evaluated lymph node detection performance of the ITRST filter on 47 contrast-enhanced chest CT volumes and compared it with the RST and Hessian filters. The detection rate of the ITRST filter was 84.2% with 9.1 FPs/volume for lymph nodes whose short axis was at least 10 mm, which outperformed the RST and Hessian filters.

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  64. Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall: A pilot study. Reviewed International journal

    Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PloS one   Vol. 12 ( 9 ) page: e0185532   2017.9

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    OBJECTIVES: To quantify the imaging findings of patients with interstitial pneumonia (IP) and emphysema using three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall, and compare the results to visual assessment of IP and each patient's diffusing capacity of the lungs for carbon monoxide (DLco). METHODS: We retrospectively reviewed the axial CT findings and pulmonary function test results of 95 patients with lung cancer (72 men and 23 women, aged 45-84 years) with or without IP, as follows: non-IP (n = 47), mild IP (n = 31), and moderate IP (n = 17). The 3D-cHRCT images of the lung at a 1-cm depth from the chest wall were reconstructed automatically using original software; total area (TA), high-attenuation area (HAA) >-500 HU, and low-attenuation area (LAA) <-950 HU were calculated on a workstation. The %HAA and %LAA were calculated as follows: [Formula: see text], and [Formula: see text]. RESULTS: The %HAA and %LAA respective values were 3.2±0.9 and 27.7±8.2, 3.9±1.2 and 27.6±5.9, and 6.9±2.2 and 25.4±8.7 in non-IP, mild IP, and moderate IP patients, respectively. There were significant differences in %HAA between the 3 groups of patients (P<0.001), but no differences in %LAA (P = 0.558). Multiple linear regression analysis revealed that %HAA and %LAA were negatively correlated with predicted DLco (standard partial regression coefficient [b*] = -0.453, P<0.001; b* = -0.447, P<0.001, respectively). CONCLUSIONS: The %HAA and %LAA values computed using 3D-cHRCT were significantly correlated with DLco and may be important quantitative parameters for both IP and emphysema.

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  65. Dual Energy CTによる小型肺癌の造影評価

    島本 宏矩, 岩野 信吾, 馬越 弘泰, 伊藤 倫太郎, 長縄 慎二

    Japanese Journal of Radiology   Vol. 35 ( Suppl. ) page: 34 - 34   2017.2

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  66. FDG-PETによる非小細胞肺癌の予後予測因子の検討 SUVmaxと体積を考慮した指標の比較

    伊藤 信嗣, 岩野 信吾, 伊藤 倫太郎, 長縄 慎二, 加藤 克彦

    核医学   Vol. 54 ( 1 ) page: 565 - 565   2017.2

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  67. 胸壁並行断面CTを用いた間質性肺炎の定量的評価

    馬越 弘泰, 岩野 信吾, 伊藤 倫太郎, 長縄 慎二

    Japanese Journal of Radiology   Vol. 35 ( Suppl. ) page: 34 - 34   2017.2

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  68. ドパミントランスポータシンチグラフィにおける解析ソフトの有用性に関する研究

    松澤 伸一郎, 加藤 克彦, 国本 啓太, 本田 将之, 椋本 竜斗, 小田川 哲郎, 阿部 真治, 藤田 尚利, 櫻木 庸博, 伊藤 信嗣, 伊藤 倫太郎, 岩野 信吾, 長縄 慎二

    核医学   Vol. 54 ( 1 ) page: 663 - 663   2017.2

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  69. Thoracic Temporal Subtraction Three Dimensional Computed Tomography (3D-CT): Screening for Vertebral Metastases of Primary Lung Cancers. Reviewed International journal

    Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Takatoshi Karino, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PloS one   Vol. 12 ( 1 ) page: e0170309   2017.1

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    PURPOSE: We developed an original, computer-aided diagnosis (CAD) software that subtracts the initial thoracic vertebral three-dimensional computed tomography (3D-CT) image from the follow-up 3D-CT image. The aim of this study was to investigate the efficacy of this CAD software during screening for vertebral metastases on follow-up CT images of primary lung cancer patients. MATERIALS AND METHODS: The interpretation experiment included 30 sets of follow-up CT scans in primary lung cancer patients and was performed by two readers (readers A and B), who each had 2.5 years' experience reading CT images. In 395 vertebrae from C6 to L3, 46 vertebral metastases were identified as follows: osteolytic metastases (n = 17), osteoblastic metastases (n = 14), combined osteolytic and osteoblastic metastases (n = 6), and pathological fractures (n = 9). Thirty-six lesions were in the anterior component (vertebral body), and 10 lesions were in the posterior component (vertebral arch, transverse process, and spinous process). The area under the curve (AUC) by receiver operating characteristic (ROC) curve analysis and the sensitivity and specificity for detecting vertebral metastases were compared with and without CAD for each observer. RESULTS: Reader A detected 47 abnormalities on CT images without CAD, and 33 of them were true-positive metastatic lesions. Using CAD, reader A detected 57 abnormalities, and 38 were true positives. The sensitivity increased from 0.717 to 0.826, and on ROC curve analysis, AUC with CAD was significantly higher than that without CAD (0.849 vs. 0.902, p = 0.021). Reader B detected 40 abnormalities on CT images without CAD, and 36 of them were true-positive metastatic lesions. Using CAD, reader B detected 44 abnormalities, and 39 were true positives. The sensitivity increased from 0.783 to 0.848, and AUC with CAD was nonsignificantly higher than that without CAD (0.889 vs. 0.910, p = 0.341). Both readers detected more osteolytic and osteoblastic metastases with CAD than without CAD. CONCLUSION: Our temporal 3D-CT subtraction CAD software easily detected vertebral metastases on the follow-up CT images of lung cancer patients regardless of the osteolytic or osteoblastic nature of the lesions.

    DOI: 10.1371/journal.pone.0170309

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    PubMed

  70. Hessian-assisted supervoxel: Structure-oriented voxel clustering and application to mediastinal lymph node detection from CT volumes Reviewed

    Hirohisa Oda, Kanwal K. Bhatia, Masahiro Oda, Takayuki Kitasaka, Shingo Iwano, Hirotoshi Homma, Hirotsugu Takabatake, Masaki Mori, Hiroshi Natori, Julia A. Schnabel, Kensaku Mori

    Progress in Biomedical Optics and Imaging - Proceedings of SPIE   Vol. 10134   2017

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    In this paper, we propose a novel supervoxel segmentation method designed for mediastinal lymph node by embedding Hessian-based feature extraction. Starting from a popular supervoxel segmentation method, SLIC, which computes supervoxels by minimising differences of intensity and distance, we overcome this method's limitation of merging neighboring regions with similar intensity by introducing Hessian-based feature analysis into the supervoxel formation. We call this structure-oriented voxel clustering, which allows more accurate division into distinct regions having blob-, line- or sheet-like structures. This way, different tissue types in chest CT volumes can be segmented individually, even if neighboring tissues have similar intensity or are of non- spherical extent. We demonstrate the performance of the Hessian-assisted supervoxel technique by applying it to mediastinal lymph node detection in 47 chest CT volumes, resulting in false positive reductions from lymph node candidate regions. 89 % of lymph nodes whose short axis is at least 10 mm could be detected with 5.9 false positives per case using our method, compared to our previous method having 83 % of detection rate with 6.4 false positives per case.

    DOI: 10.1117/12.2254782

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    Scopus

  71. Planning video-assisted thoracic surgery segmentectomy using three dimensional computed tomography angiography and bronchography with a virtual safety margin. Reviewed

    Iwano S

    Journal of visualized surgery   Vol. 3   page: 82   2017

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    DOI: 10.21037/jovs.2017.04.08

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  72. Visualization of Middle Ear Ossicles in Elder Subjects with Ultra-short Echo Time MR Imaging Reviewed

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Kojiro Suzuki, Shingo Iwano, Hiroko Satake, David Grodzki

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 16 ( 2 ) page: 93 - 97   2017

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    Purpose: To evaluate the visualization of middle ear ossicles by ultra-short echo time magnetic resonance (MR) imaging at 3T in subjects over 50 years old.
    Materials and Methods: Sixty ears from 30 elder patients that underwent surgical or interventional treatment for neurovascular diseases were included (ages: 50-82, median age: 65; 10 men, 20 women). Patients received follow-up MR imaging including routine T1-and T2-weighted images, time-of-flight MR angiography, and ultra-short echo time imaging (PETRA, pointwise encoding time reduction with radial acquisition). All patients underwent computed tomography (CT) angiography before treatment. Thin-section source CT images were correlated with PETRA images. Scan parameters for PETRA were: TR 3.13, TE 0.07, flip angle 6 degrees, 0.83 x 0.83 x 0.83 mm resolution, 3 min 43 s scan time. Two radiologists retrospectively evaluated the visibility of each ossicular structure as positive or negative using PETRA images. The structures evaluated included the head of the malleus, manubrium of the malleus, body of the incus, long process of the incus, and the stapes. Signal intensity of the ossicles was classified as: between labyrinthine fluid and air, similar to labyrinthine fluid, between labyrinthine fluid and cerebellar parenchyma, or higher than cerebellar parenchyma.
    Results: In all ears, the body of the incus was visible. The head of the malleus was visualized in 36/60 ears. The manubrium of the malleus and long process of the incus was visualized in 1/60 and 4/60 ears, respectively. The stapes were not visualized in any ear. Signal intensity of the visible structures was between labyrinthine fluid and air in all ears.
    Conclusion: The body of the incus was consistently visualized with intensity between air and labyrinthine fluid on PETRA images in aged subjects. Poor visualization of the manubrium of the malleus, long process of the incus, and the stapes limits clinical significance of middle ear imaging with current PETRA methods.

    DOI: 10.2463/mrms.mp.2015-0171

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    PubMed

  73. Evaluation of locoregional invasiveness of small-sized non-small cell lung cancers by enhanced dual-energy computed tomography Reviewed

    Shimamoto H, Iwano S, Umakoshi H, Kawaguchi K, Naganawa S

    Cancer Imaging   Vol. 16 ( 1 ) page: 18   2016.7

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    DOI: 10.1186/s40644-016-0077-1

  74. Respiratory mechanics measured by forced oscillation technique in rheumatoid arthritis-related pulmonary abnormalities: frequency-dependence, heterogeneity and effects of smoking Reviewed

    Sokai R, Ito S, Iwano S, Uchida A, Aso H, Kondo M, Ishiguro N, Kojima T, Hasegawa, Y

    Springerplus   Vol. 5   page: 335   2016.4

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    DOI: 10.1186/s40064-016-1952-8

  75. Correlation between FDG-PET/CT findings and solid type non-small cell cancer prognostic factors: are there differences between adenocarcinoma and squamous cell carcinoma? Reviewed

    Ito R, Iwano S, Kishimoto M, Ito S, Kato K, Naganawa S.

    Ann Nucl Med   Vol. 29 ( 10 ) page: 897-905   2015.9

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    DOI: 10.1007/s12149-015-1025-z

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  76. Evaluation of lung cancer by enhanced dual-energy CT: Association between three-dimensional iodine concentration and tumor differentiation. Reviewed

    Iwano S, Ito R, Umakoshi H, Ito S, Naganawa S

    Br J Radiol   Vol. 88   page: 20150224   2015.9

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    DOI: http://dx.doi.org/10.1259/bjr.20150224

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  77. The contact length between the tumor contour and the lung on computed tomography is a risk factor for pleural recurrence after complete resection of thymoma. Reviewed

    Kato T, Iwano S, Taniguchi T, Kawaguchi K, Fukui T, Ishiguro F, Fukumoto K, Nakamura S, Hirakawa A, Yokoi K.

    Gen Thorac Cardiovasc Surg   Vol. 63 ( 6 ) page: 343-348   2015.2

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    DOI: 10.1007/s11748-015-0525-z

  78. Evaluation of emphysema using three-dimensional computed tomography: association with postoperative complications in lung cancer patients Reviewed

    Kawakami K, Iwano S, Hashimoto N, Hasegawa Y, Naganawa S.

    Nagoya J Med Sci   Vol. 77 ( 1-2 ) page: 113-122   2015.2

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  79. Lobar analysis of collapsibility indices to assess functional lung volumes in COPD patients. Reviewed

    Kitano M, Iwano S, Hashimoto N, Matsuo K, Hasegawa Y, Naganawa S.

    Int J Chron Obstruct Pulmon Dis.   Vol. 9   page: 1347-1356   2014.12

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    DOI: 10.2147/COPD.S72616

  80. Prognostic evaluations of small size lung cancers by 18F-FDG PET/CT and thin-section CT. Reviewed

    Kishimoto M, Iwano S, Ito S, Kato K, Ito R, Naganawa S

    Lung Cancer   Vol. 86 ( 2 ) page: 180-184   2014.9

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    DOI: 10.1016/j.lungcan.2014.09.006

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  81. Evaluation of 11C-choline PET/CT for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract: a pilot study. Reviewed

    Sassa N, Kato K, Abe S, Iwano S, Ito S, Ikeda M, Shimamoto K, Yamamoto S, Yamamoto T, Gotoh M, Naganawa S.

    Eur J Nucl Med Mol Imaging   Vol. 41 ( 12 ) page: 2232-2241   2014.8

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    DOI: 10.1007/s00259-014-2871-y

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  82. Therapeutic surgery without a definitive diagnosis can be an option in selected patients with suspected lung cancer. Reviewed

    Ozeki N, Iwano S, Taniguchi T, Kawaguchi K, Fukui T, Ishiguro F, Fukumoto K, Nakamura S, Hirakawa A, Yokoi K.

    Interact Cardiovasc Thorac Surg   Vol. 19 ( 5 ) page: 830-837   2014.7

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    DOI: 10.1093/icvts/ivu233

  83. Prediction of pathologic prognostic factors in patients with lung adenocarcinomas: comparison of thin-section computed tomography and positron emission tomography/computed tomography. Reviewed

    Iwano S, Kishimoto M, Ito S, Kato K, Ito R, Naganawa S

    Cancer Imaging   Vol. 22 ( 14 ) page: 3   2014.4

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    DOI: 10.1186/1470-7330-14-3

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  84. Clinical impact of prevalence and severity of COPD on the decision-making process for therapeutic management of lung cancer patients. Reviewed

    Hashimoto N, Matsuzaki A, Okada Y, Imai N, Iwano S, Wakai K, Imaizumi K, Yokoi K, Hasegawa Y

    BMC Pulm Med   Vol. 5 ( 14 ) page: 14   2014.2

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    DOI: 10.1186/1471-2466-14-14

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  85. Comparison of 18F-fluoride PET/CT, 18F-FDG PET/CT and bone scintigraphy (planar and SPECT) in detection of bone metastases of differentiated thyroid cancer: a pilot study. Reviewed

    Ota N, Kato K, Iwano S, Ito S, Abe S, Fujita N, Yamashiro K, Yamamoto S, Naganawa S.

    Br J Radiol   Vol. 87 ( 1034 ) page: 20130444   2014.1

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  86. Doubling time calculations for lung cancer by three-dimensional computer-aided volumetry: effects of inter-observer differences and nodule characteristics Reviewed

    Koike, W. Iwano, S. Matsuo, K. Kitano, M. Kawakami, K. Naganawa, S.

    J Med Imaging Radiat Oncol   Vol. 58 ( 1 ) page: 82-8   2013.10

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    INTRODUCTION: The purpose of this study was to investigate doubling time (DT) differences among solid, part-solid (PS) and non-solid (NS) types of lung cancers. We also compared inter-observer differences in size measurements between diameter and three-dimensional (3D) volume measurements of lung cancers, including PS- and NS-type nodules, using 3D computer-aided volumetry (3D-CAV). METHODS: The long-axis diameters and 3D volumes of lung tumours were measured using CAV by two chest radiologists for 71 consecutive patients with peripheral lung cancer who underwent at least two CT examinations before surgical resection. We evaluated the inter-observer variability for the ratio of diameter change (RCdiameter) and volume change (RCvolume), which were based on two CT images obtained at different times prior to resection. Inter-observer agreement was evaluated by Bland-Altman plots. Based on the volumes obtained from 3D-CAV, we calculated the DTs and compared DT differences between solid, PS and NS types of lung tumours. RESULTS: The inter-observer Spearman's rank correlation coefficients were 0.87 for RCvolume and 0.64 for RCdiameter (p < 0.001). For all internal appearance types, the rs values for RCvolume were greater than those for RCdiameter. The median DT values for solid, PS and NS were 278, 347 and 584 days, respectively. NS- and PS-type tumours had significantly longer DTs (p = 0.024; by Spearman's rank correlation coefficient). CONCLUSIONS: DT determinations using 3D-CAV had good correlations with the internal appearances of lung cancers. Lung tumour volume measurements by 3D-CAV exhibited better inter-observer correlations than did diameter measurements.

    DOI: 10.1111/1754-9485.12128

    PubMed

  87. Planning of segmentectomy using three-dimensional computed tomography angiography with a virtual safety margin: technique and initial experience. Reviewed

    Iwano S, Yokoi K, Taniguchi T, Kawaguchi K, Fukui T, Naganawa S

    Lung Cancer   Vol. 81 ( 3 ) page: 410-415   2013.7

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    DOI: 10.1016/j.lungcan.2013.06.001

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  88. Limited efficacy of (18)F-FDG PET/CT for differentiation between metastasis-free pancreatic cancer and mass-forming pancreatitis. Reviewed

    Kato K, Nihashi T, Ikeda M, Abe S, Iwano S, Itoh S, Shimamoto K, Naganawa S

    Clinical nuclear medicine   Vol. 38 ( 6 ) page: 417-21   2013.6

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    DOI: 10.1097/RLU.0b013e3182817d9d

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  89. Pulmonary lobar volumetry using novel volumetric computer-aided diagnosis and computed tomography Reviewed

    Iwano S, Kitano M, Matsuo K, Kawakami K, Koike W, Kishimoto M, Inoue T, Li Y, Naganawa S

    Interact Cardiovasc Thorac Surg   Vol. 17 ( 1 ) page: 59-65   2013.3

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    DOI: 10.1093/icvts/ivt122

  90. What causes false-negative PET findings for solid-type lung cancer? Reviewed

    Iwano S, Ito S, Tsuchiya K, Kato K, Naganawa S

    Lung cancer (Amsterdam, Netherlands)   Vol. 79 ( 2 ) page: 132-6   2013.2

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    DOI: 10.1016/j.lungcan.2012.10.018

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  91. Supplemental value of diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) technique to whole-body magnetic resonance imaging in detection of bone metastases from thyroid cancer. Reviewed

    Sakurai Y, Kawai H, Iwano S, Ito S, Ogawa H, Naganawa S

    J Med Imaging Radiat Oncol   Vol. 57 ( 3 ) page: 297-305   2012.12

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    DOI: 10.1111/1754-9485.12020

  92. An anomalous segmental vein of the left upper lobe of the lung: preoperative identification by three-dimensional computed tomography pulmonary angiography. Reviewed

    Ishikawa Y, Iwano S, Usami N, Yokoi K

    Interactive cardiovascular and thoracic surgery   Vol. 15 ( 3 ) page: 512-3   2012.9

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    DOI: 10.1093/icvts/ivs205

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  93. Correlation between dynamic CT findings and pathological prognostic factors of small lung adenocarcinoma. Reviewed

    Iwano S, Koike W, Matsuo K, Kitano M, Kawakami K, Okada T, Naganawa S

    Cancer imaging : the official publication of the International Cancer Imaging Society   Vol. 12   page: 187-93   2012.6

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    DOI: 10.1102/1470-7330.2012.0018

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  94. 3D-CT lung volumetry using multidetector row computed tomography: pulmonary function of each anatomic lobe. Reviewed

    Matsuo K, Iwano S, Okada T, Koike W, Naganawa S

    Journal of thoracic imaging   Vol. 27 ( 3 ) page: 164-70   2012.5

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    DOI: 10.1097/RTI.0b013e31822641c9

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  95. FDG-PET performed concurrently with initial I-131 ablation for differentiated thyroid cancer. Reviewed

    Iwano S, Kato K, Ito S, Tsuchiya K, Naganawa S

    Annals of nuclear medicine   Vol. 26 ( 3 ) page: 207-13   2012.4

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    DOI: 10.1007/s12149-011-0559-y

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  96. Mediastinal atlas creation from 3-D chest computed tomography images: application to automated detection and station mapping of lymph nodes. Reviewed

    Feuerstein M, Glocker B, Kitasaka T, Nakamura Y, Iwano S, Mori K

    Medical image analysis   Vol. 16 ( 1 ) page: 63-74   2012.1

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    DOI: 10.1016/j.media.2011.05.005

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  97. Correlation between dual-phase dynamic multi-detector CT findings and fibrosis within lung adenocarcinoma tumors. Reviewed

    Iwano S, Koike W, Matsuo K, Okada T, Shimoyama Y, Naganawa S

    European journal of radiology   Vol. 80 ( 3 ) page: e470-5   2011.12

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    DOI: 10.1016/j.ejrad.2010.09.007

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  98. *Virtual bronchoscopy-guided transbronchial biopsy for aiding the diagnosis of peripheral lung cancer. Reviewed

    Iwano S, Imaizumi K, Okada T, Hasegawa Y, Naganawa S.

    Eur J Radiol   Vol. 79 ( 1 ) page: 155-159   2011.7

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    DOI: 10.1016/j.ejrad.2009.11.023

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  99. Diagnostic value of SPIO-mediated breath-hold, black-blood, fluid-attenuated, inversion recovery (BH-BB-FLAIR) imaging in patients with hepatocellular carcinomas.

    MATSUSHIMA MASAYA, NAGANAWA SHINJI, IKEDA MITSURU, ITOH SHIGEKI, OGAWA HIROSHI, KOMADA TOMOHIRO, ISHIGAKI SATOKO, KAWAI HISASHI, SUZUKI KOJIRO, SATAKE HIROKO, IWANO SHINGO

    Magn Reason Med Sci   Vol. 9 ( 2 ) page: 49-58   2010.9

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  100. Estimation of Gadolinium-induced T(1)-shortening with Measurement of Simple Signal Intensity Ratio between the Cochlea and Brain Parenchyma on 3D-FLAIR: Correlation with T(1) Measurement by TI Scout Sequence.

    NAGANAWA SHINJI, ISHIHARA SHUNICHI, IWANO SHINGO, KAWAI HISASHI, SONE MICHIHIKO, NAKASHIMA TSUTOMU

    Magn Reson Med Sci   Vol. 9 ( 1 ) page: 17-22   2010.9

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  101. Three-dimensional angiography of aberrant segmental vein of right upper lobe. Reviewed

    Usami N, Iwano S, Mizuno T, Taniguchi T, Yokoi K

    Asian cardiovascular & thoracic annals   Vol. 18 ( 4 ) page: 398   2010.8

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    DOI: 10.1177/0218492310375005

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  102. Differential TH1/TH2 chemokine expression in interstitial pneumonia. Reviewed

    Honda T, Imaizumi K, Yokoi T, Hashimoto N, Hashimoto I, Kawabe T, Matsuo M, Iwano S, Shimokata K, Hasegawa Y.

    Am J Med Sci.   Vol. 339 ( 1 ) page: 41-48   2010.1

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  103. Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T. Reviewed

    Naganawa S, Ishihara S, Iwano S, Sone M, Nakashima T.

    J Magn Reson Imaging   Vol. 31 ( 1 ) page: 210-214   2010

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  104. Comparisons of I-123 diagnostic and I-131 post-treatment scans for detecting residual thyroid tissue and metastases of differentiated thyroid cancer. Reviewed

    Iwano S, Kato K, Nihashi T, Ito S, Tachi Y, Naganawa S

    Annals of nuclear medicine   Vol. 23 ( 9 ) page: 777-82   2009.11

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    DOI: 10.1007/s12149-009-0303-z

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  105. Semi-automatic volumetric measurement of lung cancer using multi-detector CT effects of nodule characteristics. Reviewed

    Iwano S, Okada T, Koike W, Matsuo K, Toya R, Yamazaki M, Ito S, Ito J, Naganawa S.

    Acad Radiol.   Vol. 16 ( 10 ) page: 1179-86   2009.10

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  106. 【ボーダレス時代のPACS&WS選び 高機能化と多機能化が画像診断に福音をもたらす】 PACS&WS導入施設報告 PACSと3D WS併用施設報告 仮想気管支鏡(virtual bronchoscopy)の配信におけるPACSとWSの連携

    岩野信吾

    INNERVISION   Vol. 24 ( 7 ) page: 27-29   2009.6

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  107. *3D-CT volumetry of the lung using multidetector row CT: comparison with pulmonary function tests.

    Iwano, Shingo; Okada, Tohru; Satake, Hiroko; Naganawa, Shinji

    Acad Radiol   ( 16 ) page: 250-256   2009.3

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    RATIONALE AND OBJECTIVES: The aim of this study was to evaluate the accuracy of measurements of lung volumes reconstructed using three-dimensional computed tomographic (CT) imaging from thin-section multidetector-row CT images compared to standard pulmonary function testing. MATERIALS AND METHODS: Preoperative three-dimensional CT images and pulmonary function test results of 64 patients with solitary pulmonary nodules who were considered candidates for lung resection were reviewed. On the three-dimensional CT images, total lung capacity (TLC(CTV)), emphysematous lung capacity (ELC(CTV)), and normal lung capacity (NLC(CTV)) were calculated. Total lung capacity (TLC), vital capacity, and forced expiratory volume in 1 second were measured using spirometry. RESULTS: There was a strong positive correlation between estimated TLC(CTV) and measured TLC values (r = 0.87, P < .001). Estimated ELC(CTV) at the threshold value of -900 Hounsfield units was negatively correlated with forced expiratory volume in 1 second (r = -0.56, P < .001). NLC(CTV) values were more strongly correlated with vital capacity values than TLC(CTV) values (r = 0.74, P < .001). CONCLUSIONS: Lung volume calculated using three-dimensional CT volumetry was well correlated with lung volume measured using spirometry. Three-dimensional CT volumetry can be used to evaluate pulmonary function.

  108. Computer-aided diagnosis of lung cancer: definition and detection of ground-glass opacity type of nodules by high-resolution computed tomography. Reviewed

    Okada T, Iwano S, Ishigaki T, Kitasaka T, Hirano Y, Mori K, Suenaga Y, Naganawa S.

    Jpn J Radiol.   Vol. 27 ( 2 ) page: 91-99   2009.2

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    PURPOSE: The ground-glass opacity (GGO) of lung cancer is identified only subjectively on computed tomography (CT) images as no quantitative characteristic has been defined for GGOs. We sought to define GGOs quantitatively and to differentiate between GGOs and solid-type lung cancers semiautomatically with a computer-aided diagnosis (CAD). METHODS AND MATERIALS: High-resolution CT images of 100 pulmonary nodules (all peripheral lung cancers) were collected from our clinical records. Two radiologists traced the contours of nodules and distinguished GGOs from solid areas. The CT attenuation value of each area was measured. Differentiation between cancer types was assessed by a receiver-operating characteristic (ROC) analysis. RESULTS: The mean CT attenuation of the GGO areas was -618.4 +/- 212.2 HU, whereas that of solid areas was -68.1 +/- 230.3 HU. CAD differentiated between solidand GGO-type lung cancers with a sensitivity of 86.0% and specificity of 96.5% when the threshold value was -370 HU. Four nodules of mixed GGOs were incorrectly classified as the solid type. CAD detected 96.3% of GGO areas when the threshold between GGO and solid areas was 194 HU. CONCLUSION: Objective definition of GGO area by CT attenuation is feasible. This method is useful for semiautomatic differentiation between GGOs and solid types of lung cancer.

  109. Detection of presumed hemorrhage in the ampullar endolymph of the semicircular canal: a case report. Reviewed

    Naganawa S, Ishihara S, Iwano S, Sone M, Nakashima T.

    Magn Reson Med Sci.   Vol. 8 ( 4 ) page: 187-191   2009

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  110. Automated anatomical labeling of bronchial branches extracted from CT datasets based on machine learning and combination optimization and its application to bronchoscope guidance. Reviewed

    Mori K, Ota S, Deguchi D, Kitasaka T, Suenaga Y, Iwano S, Hasegawa Y, Takabatake H, Mori M, Natori H

    Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention   Vol. 12 ( Pt 2 ) page: 707-14   2009

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  111. Diagnostic whole-body scanning before radioiodine therapy for pulmonary metastases of differentiated thyroid cancer: predictive value and recommendations. Reviewed

    Tachi Y, Iwano S, Kato K, Tadokoro M, Naganawa S

    Clin Nucl Med   Vol. 33 ( 12 ) page: 845-51   2008.12

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    RATIONALE:: Radioiodine therapy improves the survival of patients with pulmonary metastases of differentiated thyroid cancer (DTC). It is controversial whether the diagnostic whole-body I-131 scan (DWS) before therapy is essential. We determined whether DWS could predict the efficacy of I-131 therapy for pulmonary metastases. METHODS:: We undertook a retrospective review of records of 42 patients (28 women and 14 men, mean age 52.7 years). The patients had received 62 rounds of I-131 therapy for lung metastases of DTC at our institution between June 2002 and June 2006. On the same day that the DWS (dose of 185 MBq) (5 mCi) was completed, the patient received I-131 therapy (dose of 3700-7400 MBq) (100-200 mCi). Post-therapy whole-body scans (PWS) were performed after 3 to 4 days and 7 to 8 days. For all therapies, chest CT images were obtained before I-131 therapy, and 3 and 6 months after therapy for evaluation of therapeutic effectiveness. In addition, serum thyroglobulin (Tg) values were measured before and after the radioiodine therapy for all treatments. RESULTS:: In the group demonstrating I-131 accumulation for pulmonary metastases on DWS, 72% of patients showed a reduction of pulmonary metastases on follow-up CT. On the other hand, in the group that failed to accumulate I-131 on DWS, only 5% of patients showed a reduction of pulmonary metastases. After therapy, serum Tg levels decreased significantly in the group that initially showed accumulation of I-131 in DWS (P = 0.045). In contrast, no remarkable changes between pre- and post-therapy Tg levels were observed in patients who failed to accumulate I-131 in DWS. CONCLUSION:: A whole-body I-131 diagnostic scan before I-131 therapy has a predictive value for the efficacy of therapeutic radioiodine treatment for pulmonary metastases of differentiated thyroid cancer.

  112. Communication between cochlear perilymph and cerebrospinal fluid through the cochlear modiolus visualized after intratympanic administration of Gd-DTPA.

    Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Sone, Michihiko; Nakashima, Tsutomu

    Radiat Med   Vol. 26   page: 597-602   2008.9

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  113. *Computer-aided differentiation of malignant from benign solitary pulmonary nodules imaged by high-resolution CT. Reviewed

    Iwano S, Nakamura T, Kamioka Y, Ikeda M, Ishigaki T.

    Comput Med Imaging Graph.   Vol. 32 ( 5 ) page: 416-22.   2008.7

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    We investigated the possibility of using computer analysis of high-resolution CT images to radiologically classify the shape of pulmonary nodules. From a total of 107 HRCT images of solid, solitary pulmonary nodules with prior differentiation as benign (n=55) or malignant (n=52), we extracted the desired pulmonary nodules and calculated two quantitative parameters for characterizing nodules: circularity and second central moment. Using discriminant analysis for two thresholds in differentiating malignant from benign states resulted in a sensitivity of 76.9%, a specificity of 80%, a positive predictive value of 78.4%, and a negative predictive value of 78.6%.

  114. Contrast-enhanced MR imaging of the brain using T1-weighted FLAIR with BLADE compared with a conventional spin-echo sequence.

    Naganawa Shinji, Satake Hiroko, Iwano Shingo, Kawai Hisashi, Kubota Seiji, Komada Tomohiro, Kawamura Minako, Sakurai Yasuo, Fukatsu Hiroshi

    Eur Radiol   Vol. 18 ( 2 ) page: 337-342   2008.2

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  115. Interactions of perceptual and conceptual processing:Expertise in medical image diagnosis.

    Morita, J., Miwa, K., Kitasaka, T., Mori, K., Suenaga, Y., Iwano, S., Ikeda, M., and Ishigaki, T

    Int. J. Human-computer Studies   Vol. 66 ( 208 ) page: 370-390   2008

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  116. Imaging endolymphatic hydrops at 3 tesla using 3D-FLAIR with intratympanic Gd-DTPA administration.

    Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Fukatsu, Hiroshi; Sone, Michihiko; Nakashima, Tsutomu

    Magn Reson Med Sci   Vol. 7   page: 85-91   2008

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  117. Solitary fibrous tumor of the pleura: evaluation of the origin with 3D CT angiography. Reviewed

    Usami N, Iwano S, Yokoi K.

    J Thorac Oncol.   Vol. 2 ( 12 ) page: 1124-5.   2007.12

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  118. 類似CT画像検索CADの試み

    岩野信吾, 岡田徹, 神岡祐子, 石垣武男, 長縄慎二

    映像情報Medical   Vol. 39 ( 13 ) page: 1215-19   2007.12

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  119. Usefulness of dynamic computed tomography for the diagnosis of mediastinal hemangioma. Reviewed

    Okasaka T, Iwano S, Usami N, Uchiyama M, Sato N, Yokoi K.

      Vol. 60 ( 11 ) page: 1031-4   2007.10

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  120. Comparison of 18F-FDG PET and Bone Scintigraphy in Detection of Bone Metastases of Thyroid Cancer.

    Ito S, Kato K, Ikeda M, Iwano S, Makino N, Tadokoro M, Abe S, Nakano S, Nishino M, Ishigaki T, Naganawa S

    J Nucl Med   Vol. 48   page: 889-895   2007

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    We compared the efficacies of (18)F-FDG PET and (99m)Tc-bone scintigraphy for the detection of bone metastases in patients with differentiated thyroid carcinoma (DTC). METHODS: We examined 47 patients (32 women, 15 men; mean age +/- SD, 57.0 +/- 10.7 y) with DTC who had undergone total thyroidectomy and were hospitalized to be given (131)I therapy. All patients underwent both whole-body (18)F-FDG PET and (99m)Tc-bone scintigraphy. The skeletal system was classified into 11 anatomic segments and assessed for the presence of bone metastases. Bone metastases were verified either when positive findings were obtained on >2 imaging modalities-(201)Tl scintigraphy, (131)I scintigraphy, and CT-or when MRI findings were positive if vertebral MRI was performed. RESULTS: Bone metastases were confirmed in 59 of 517 (11%) segments in 18 (38%) of the 47 study patients. The sensitivities (visualization rate) for bone metastases on a segment basis using (18)F-FDG PET and (99m)Tc-bone scintigraphy were 50 of 59 (84.7%) and 46 of 59 (78.0%), respectively; the difference between these values was not statistically significant. There were only 2 (0.4%) false-positive cases in a total of 451 bone segments without bone metastases when examined by (18)F-FDG PET, whereas 39 (8.6%) were false-positive when examined by (99m)Tc-bone scintigraphy. Therefore, the specificities of (18)F-FDG PET and (99m)Tc-bone scintigraphy were 449 of 451 (99.6%) and 412 of 451 (91.4%), respectively; the difference between these values was statistically significant (P < 0.001). The overall accuracies of (18)F-FDG PET and (99m)Tc-bone scintigraphy were 499 of 510 (97.8%) and 458 of 510 (89.8%), respectively; the difference between these was also statistically significant (P patients has recently improved. In particular, patients with good PS showed better local control than those with poor PS. However, we could not identify any significant prognostic factors in PCNSL patients.

  121. 【膵疾患の画像診断 最近のトレンド】 マルチスライスCT診断

    伊藤茂樹, 石垣聡子, 鈴木耕次郎, 岩野信吾, 長縄慎二

    臨床画像   Vol. 22 ( 12 ) page: 1334-1342   2006.12

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  122. Application of subsecond rotation scan to helical CT for lung cancer screening. Reviewed

    Mori Y, Itoh S, Ikeda M, Sawaki A, Suzuki K, Iwano S, Satake H, Arahata S, Ota T, Ishigaki T

    Nagoya journal of medical science   Vol. 68 ( 3-4 ) page: 139-45   2006.6

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  123. Cerebral glucose metabolism change in patients with complex regional pain syndrome: a PET study.

    Shiraishi S, Kobayashi H, Nihashi T, Kato K, Iwano S, Nishino M, Ishigaki T, Ikeda M, Kato T, Ito K, Kimura T

    Radiat Med   Vol. 24   page: 335-344   2006

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    PURPOSE: The aim of this study was to examine abnormalities of the central nervous system in patients with chronic pain who were diagnosed with complex regional pain syndrome (CRPS). MATERIALS AND METHODS: Brain activity was assessed using (18)F-fluorodeoxyglucose positron emission tomography. The data collected from 18 patients were compared with data obtained from 13 normal age-matched controls. RESULTS: Our results showed that glucose metabolism was bilaterally increased in the secondary somatosensory cortex, mid-anterior cingulated cortex (ACC) or posterior cingulated cortex (PCC) (or both), parietal cortex, posterior parietal cortex (PPC), and cerebellum as well as in the right posterior insula and right thalamus in our patients. In contrast, glucose metabolism was reduced contralaterally in the dorsal prefrontal cortex and primary motor cortex. Glucose metabolism was bilaterally elevated in the mid-ACC/PCC and the PPC, which correlated with pain duration. CONCLUSION: These data suggested that glucose metabolism in the brains of patients with CRPS changes dramatically at each location. In particular, glucose metabolism was increased in the areas concerned with somatosensory perception, possibly due to continuous painful stimulation.

  124. Application of subsecond rotation scan to helical CT for lung cancer screening.

    Mori, Yoshine; Itoh, Shigeki; Ikeda, Mitsuru; Sawaki, Akiko; Suzuki, Koujiro; Iwano, Shingo; Satake, Hiroko; Arahata, Shoji; Ota, Toyohiro; Ishigaki, Takeo

    Nagoya J Med Sci   Vol. 68   page: 139-145   2006

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    PURPOSE: To clarify whether the benefit of a reduced effective scan width obtained using a smaller pitch outweighs the disadvantage of increased noise in the application of a subsecond helical CT to mass screenings for lung cancer. MATERIALS AND METHODS: Twenty-two helical CT scans of the lung were obtained in 11 healthy subjects using the following parameters: 1) scan 1 was performed at 120 kVp, 50 mA, 10-mm collimation, 1-second/rotation, helical pitch of 2.0; and 2) scan 2 was performed at 120 kVp, 50 mA, 10-mm collimation, 0.75-second/rotation, helical pitch of 1.5. Computer-generated nodules measuring 10 mm and 6 mm in diameter showing ground-glass opacity were superimposed on these images. The detectability of each nodule was evaluated by six blinded readers using ROC analysis. RESULTS: Detectability of the 6-mm nodules was significantly higher in scan 2 than in scan 1. Detectability of the 10-mm nodules was not significantly different between scans 1 and 2. CONCLUSION: The use of a smaller pitch by employing a subsecond rotation scan in a helical CT for lung cancer screenings improves the detection of small lesions without increasing either the scanning time or radiation dose.

  125. Diagnostic value of curved multiplanar reformatted images in multislice CT for the detection of resectable pancreatic ductal adenocarcinoma.

    Fukushima H, Itoh S, Takada A, Mori Y, Suzuki K, Sawaki A, Iwano S, Satake H, Ota T, Ikeda M, Ishigaki T

    Eur Radiol   Vol. 16   page: 1709-1718   2006

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    The purpose of this study was to assess the usefulness of curved multiplanar reformatted (MPR) images obtained by multislice CT for the depiction of the main pancreatic duct (MPD) and detection of resectable pancreatic ductal adenocarcinoma. This study included 28 patients with pancreatic carcinoma (size range 12-40 mm) and 22 without. Curved MPR images with 0.5-mm continuous slices were generated along the long axis of the pancreas from pancreatic-phase images with a 0.5- or 1-mm slice thickness. Seven blinded readers independently interpreted three sets of images (axial images, curved MPR images, and both axial and curved MPR images) in scrolling mode. The depiction of the MPD and the diagnostic performance for the detection of carcinoma were statistically compared among these images. MPR images were significantly superior to axial images in depicting the MPD, and the use of both axial and MPR images resulted in further significant improvements. For the detection of carcinoma, MPR images were equivalent to axial images, and the diagnostic performance was significantly improved by the use of both axial and MPR images. High-resolution curved MPR images can improve the depiction of the MPD and the diagnostic performance for the detection of carcinoma compared with axial images alone.

  126. 皮膚原発悪性黒色腫と転移巣における123I-IMPシンチグラフィ 18F-FDG PETとの比較

    加藤克彦, 伊藤信嗣, 岩野信吾, 石垣武男, 池田充, 田所匡典, 小林英敏

    核医学   Vol. 43   page: 360   2006

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  127. 甲状腺癌の骨転移診断における18F-FDG-ペTと骨シンチグラフィの比較

    伊藤信嗣、加藤克彦、岩野信吾、石垣武男、田所匡典、牧野直樹、池田充

    核医学   Vol. 43   page: 95   2006

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  128. *Computer-aided diagnosis: A shape classification of pulmonary nodules imaged by high-resolution CT. Reviewed

    Iwano S, Nakamura T, Kamioka Y, Ishigaki T

    Comput Med Imaging Graph.   Vol. 29 ( 7 ) page: 565-570   2005

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    We investigated the possibility of using computer analysis of high-resolution CT images to radiologically classify the shape of pulmonary nodules. Using a combination of circularity and second moment as quantitative measures we were able to classify pulmonary nodules in each shape group as effectively as could a radiologist. We found that pulmonary nodules with circularity < or =0.75 and second moment < or =0.18 were very likely to reveal lung cancer.

  129. Three-phase CT examination of the pancreatobiliary region using multislice CT with 1-mm collimation.

    Itoh S, Suzuki K, Iwano S, Satake H, Ota T, Ikeda M, Ishigaki T

    Radiat Med   Vol. 23   page: 283-291   2005

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    PURPOSE: To evaluate the degree of contrast enhancement and accuracy of imaging of the circulatory phase in the first-pass, second-pass, and third-pass acquisitions in the pancreato-biliary region with 1-mm collimation obtained by multislice computed tomography (CT). MATERIALS AND METHODS: In 53 patients, two sequential acquisitions from the porta hepatis to the pancreas were performed during a single breath-hold, followed by a third-pass acquisition including the liver beginning 15 sec after the second-pass acquisition. Contrast enhancement in each acquisition was measured in the aorta, portal vein and its branches, and pancreas. Four experienced radiologists graded using four-point scoring whether or not each acquisition was appropriate for imaging of the arterial phase, pancreatic phase, and portal venous phase. RESULTS: Aortic enhancement was highest at the beginning of the second-pass acquisition. The portal and splenic veins and pancreas showed maximum enhancement in the second-pass acquisition, while the superior mesenteric vein showed maximum enhancement in the third-pass acquisition. In the visual assessment, significantly higher grades were achieved in the first-pass, second-pass, and third-pass acquisitions with regard to imaging of the arterial phase, pancreatic phase, and portal venous phase, respectively. CONCLUSION: Multislice CT permits the acquisition of three distinct circulatory phases (arterial, pancreatic, and portal venous phases) in the pancreatobiliary region with 1-mm collimation.

  130. Branch duct-type intraductal papillary mucinous tumor: diagnostic value of multiplanar reformatted images in multislice CT.

    Takada A, Itoh S, Suzuki K, Iwano S, Satake H, Ota T, Ikeda M, Ishigaki T

    Eur Radiol   Vol. 15   page: 1888-1897   2005

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    The object of this study was to evaluate the usefulness of high-resolution multiplanar reformatted (MPR) images obtained by multislice CT in demonstrating connection between pancreatic cystic lesions and the main pancreatic duct. The study included 27 lesions with connection to the main pancreatic duct and 12 lesions without. All but one of the former lesions were branch duct-type intraductal papillary mucinous tumors (IPMTs). Oblique and curved MPR images with 0.5 mm continuous slices were generated from pancreatic-phase axial images reconstructed with 0.5 mm or 1 mm thickness at 0.5 mm intervals over a 260 mm field of view. The diagnostic capabilities for demonstrating connection with the main pancreatic duct were compared among axial images, MPR images, and both axial and MPR images in combination using the Brier score. The diagnosis in MPR images for demonstrating connection was more certain than that in axial images (P<0.05). Compared with MPR images alone, the use of both axial and MPR images resulted in further improvements in diagnostic performance, although the difference was not statistically significant. The use of high-resolution MPR images significantly improves diagnostic performance for demonstrating connection between pancreatic cystic lesions and the main pancreatic duct, which is useful for the diagnosis of branch duct-type IPMT.

  131. Solitary pulmonary nodules: Optimal slice thickness of high-resolution CT in differentiating malignant from benign. Reviewed

    Iwano S, Makino N, Ikeda M, Itoh S, Tadokoro M, Satake H, Ishigaki T

    Clinical Imaging   Vol. 28   page: 322-328   2004

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  132. Late-arterial and portal-venous phase imaging of the liver with a multislice CT scanner in patients without circulatory disturbances: automatic bolus tracking or empirical scan delay?

    Itoh S, Ikeda M, Achiwa M, Satake H, Iwano S, Ishigaki T

    Eur Radiol   Vol. 14   page: 1665-1673   2004

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    The value of automatic bolus tracking in late-arterial and portal-venous phase imaging of the liver with a multislice CT scanner as compared with fixed time-delay examination in patients without circulatory disturbances is evaluated. For the evaluation of known or suspected liver disease, 98 multiphase contrast-enhanced CT examinations including double late-arterial phase imaging were randomized into either scanning with a scan delay of 30 s from the beginning of contrast material injection or scanning with automatic bolus tracking. Contrast material was injected at 0.07 ml/kg body weight/s over 30 s. Contrast enhancement in each acquisition was measured in the aorta, portal vein, liver, pancreas and hepatocellular carcinomas. The density difference between hepatocellular carcinomas and the hepatic parenchyma was calculated. The mean time to the first-pass acquisition as determined by automatic bolus tracking was 29.6 s. No statistically significant difference was observed between the two groups either in any enhancement in any acquisition or in the lesion-to-liver density difference. The use of automatic bolus tracking in late-arterial and portal-venous phase hepatic CT does not significantly improve the degree of contrast enhancement in the aorta, portal vein, liver and pancreas or lesion-to-liver conspicuity in patients without circulatory disturbances.

  133. Lung: feasibility of a method for changing tube current during low-dose helical CT.

    Itoh S, Ikeda M, Mori Y, Suzuki K, Sawaki A, Iwano S, Satake H, Arahata S, Isomura T, Ozaki M, Ishigaki T

    Radiology   Vol. 224   page: 905-912   2002

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    A method for changing the tube current during helical scanning was applied to low-dose computed tomography (CT) in the lung. The changing method resulted in significant equalization of image noise in various lung sections compared with that at scanning with constant tube current. Detectability of nodules was equivalent between 60 mA and the changing method, whereas degradation occurred at 20 mA. This method seems feasible for the low-dose CT of lung cancer screening.

  134. Detection of Subtle Pulmonary Disease on CR Chest Images: Monochromatic CRT Monitor vs. Color CRT Monitor Reviewed

    Iwano S, Ishigaki T, Shimamoto K, Inamura K, Maeda T, Ikeda M, Ishiguchi T, Kozuka T

    European Radiology   Vol. 11 ( 1 ) page: 59-94   2001.1

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  135. Further reduction of radiation dose in helical CT for lung cancer screening using small tube current and a newly designed filter.

    Itoh S, Koyama S, Ikeda M, Ozaki M, Sawaki A, Iwano S, Ishigaki T

    J Thorac Imaging   Vol. 16   page: 81-88   2001

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    A new aluminum filter, 5.8 mm thick at the center, was designed. The effective energy, exposure dose, absorbed dose, and noise were measured by using low-dose technique, very low-dose technique with a conventional filter, and very low-dose technique with a new filter on a chest phantom. Accuracy of very low-dose computed tomography (CT) with a new filter was compared against standard helical CT in 40 patients and against chest radiography in 35 patients. Effective energies were 42.6 keV and 51.6 keV at a conventional filter and the new filter, respectively. Compared against 20mA with a conventional filter, exposure dose was reduced by 17%, and absorbed dose was equivalent, at 30 mA with the new filter. Noise was improved by 9%. Compared with standard helical CT, the sensitivity, specificity, and accuracy of very-low-dose helical CT were 100%, 88%, and 95%, respectively. Very-low-dose helical CT was found to be significantly superior to chest radiography in the detection of lung cancers. Using a smaller tube current and an appropriate filter allows a further reduction in radiation dose in helical CT for lung cancer screening.

  136. Videotaped Helical CT Images for Lung Cancer Screening Reviewed

    Iwano S, Makino N, Ikeda M, Itoh S, Ishihara S, Tadokoro M, Ishigaki T.

    J Comput Assist Tomogr   Vol. 24 ( 2 ) page: 242-246   2000.3

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Books 3

  1. 核医学技術総論

    日本核医学技術学会:編( Role: Joint author)

    山川印刷株式会社  2008.9 

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    Language:Japanese

  2. 基礎からの臨床医学-放射線診療に携わる人のために

    島本佳寿広、野田明子、太田豊裕、加藤克彦、金澤寛明、岩瀬三紀、岩野信吾、伊藤茂樹、澤木明子、佐竹弘子、福嶋洋道、小幡康範、池田充( Role: Joint author)

    名古屋大学出版会  2005 

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    Language:Japanese

  3. 新版 基礎からの臨床医学

    島本佳寿広他( Role: Joint author)

    名古屋大学出版会  2013.9  ( ISBN:978-4-8158-0739-9

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    Language:Japanese

MISC 18

  1. COVID-19 肺炎におけるAI研究の動向および問題点について

    伊藤倫太郎, 伊藤倫太郎, 岩野信吾, 岩野信吾, 長縄慎二, 長縄慎二

    医用画像情報学会雑誌(Web)   Vol. 38 ( 2 )   2021

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  2. The artificial intelligence for COVID-19 pneumonia.

    伊藤倫太郎, 伊藤倫太郎, 岩野信吾, 長縄慎二

    月刊臨床免疫・アレルギー科   Vol. 75 ( 2 )   2021

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  3. TNM分類(UICC8版)に基づいた臨床病期I期肺癌の予後評価

    岩野信吾, 馬越弘泰, 神谷晋一朗, 島本宏矩, 伊藤倫太郎, 長縄慎二

    Japanese Journal of Radiology   Vol. 38 ( Supplement )   2020

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  4. Size Measurements of Lung Cancer Using 3D-CT and PET/CT

    岩野信吾, 伊藤信嗣, 伊藤倫太郎, 神谷晋一朗, 加藤克彦, 長縄慎二

    画像診断   Vol. 40 ( 5 )   2020

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  5. GANによるCT肺結節画像の生成

    浜口拓真, 木戸尚治, 平野靖, 岩野信吾

    日本医用画像工学会大会予稿集(CD-ROM)   Vol. 38回   page: 320 - 327   2019.7

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    J-GLOBAL

  6. FDG-PET/CTの腫瘍代謝容積に基づいた肺腺癌の臨床病期診断の試み

    岩野信吾, 伊藤倫太郎, 長縄慎二

    肺癌(Web)   Vol. 59 ( 2 )   2019

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  7. 原発性肺癌の術前臨床病期診断の正確性

    岩野信吾, 馬越弘泰, 伊藤倫太郎, 島本宏矩, 長縄慎二

    Japanese Journal of Radiology   Vol. 37 ( Supplement )   2019

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  8. 人工知能が医療を変える!医療分野におけるAI研究開発最前線2019 II 領域別・画像診断におけるAI研究開発の最前線 2.胸部領域 胸部画像診断におけるAIと臨床研究について

    伊藤倫太郎, 岩野信吾, 長縄慎二

    Innervision   Vol. 34 ( 7 )   2019

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  9. Multi-window levels and widths imaging:画像変換による新たな読影手法の検討

    伊藤倫太郎, 岩野信吾, 小田紘久, 森健策, 長縄慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 55th   2019

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  10. Generative Adversarial Networkを用いた肺結節の画像生成について

    伊藤倫太郎, 岩野信吾, 長縄慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 54th   2018

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  11. 非小細胞肺癌の局所浸潤性の予測に関する造影dual energy CTとFDG-PET/CTの比較

    伊藤倫太郎, 岩野信吾, 島本宏矩, 馬越弘泰, 伊藤信嗣, 長縄慎二, 加藤克彦

    Japanese Journal of Radiology   Vol. 36 ( Supplement )   2018

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  12. 胸壁並行断面CTを用いた間質性肺炎の経時的評価

    馬越弘泰, 岩野信吾, 伊藤倫太郎, 島本宏矩, 長縄慎二

    Japanese Journal of Radiology   Vol. 36 ( Supplement )   2018

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  13. PET/CTによる小型肺癌の術後予後予測 臨床病期と病理病期との比較

    岩野 信吾, 伊藤 倫太郎, 長縄 慎二, 川口 晃司, 福井 高幸, 横井 香平

    肺癌   Vol. 57 ( 5 ) page: 453 - 453   2017.9

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    Language:Japanese   Publisher:(NPO)日本肺癌学会  

  14. PET/CTは小型肺癌のTNM分類に基づく術後予後予測を補助する

    岩野 信吾, 馬越 弘泰, 伊藤 倫太郎, 伊藤 信嗣, 川口 晃司, 福井 高幸, 横井 香平, 加藤 克彦, 長縄 慎二

    核医学   Vol. 54 ( Suppl. ) page: S195 - S195   2017.9

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    Language:Japanese   Publisher:(一社)日本核医学会  

  15. Dual Energy CTによる小型肺癌の造影評価

    島本宏矩, 岩野信吾, 馬越弘泰, 伊藤倫太郎, 長縄慎二

    Japanese Journal of Radiology   Vol. 35 ( Supplement )   2017

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  16. 脈絡膜悪性黒色腫の診断におけるIMP SPECT,FDG PET/CT,FDOPA PET/CTの比較

    加藤克彦, 小田川哲郎, 阿部真治, 山口博司, 伊藤倫太郎, 伊藤信嗣, 岩野信吾, 長縄慎二

    核医学(Web)   Vol. 54 ( Supplement )   2017

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  17. 胸壁並行断面CTを用いた間質性肺炎の定量的評価

    馬越弘泰, 岩野信吾, 伊藤倫太郎, 長縄慎二

    Japanese Journal of Radiology   Vol. 35 ( Supplement )   2017

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  18. PET/CTは小型肺癌のTNM分類に基づく術後予後予測を補助する

    岩野信吾, 馬越弘泰, 伊藤倫太郎, 伊藤信嗣, 川口晃司, 福井高幸, 横井香平, 加藤克彦, 長縄慎二

    核医学(Web)   Vol. 54 ( Supplement )   2017

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Presentations 35

  1. Dual-Energy CT for Thoracic Malignancy Invited International conference

    Shingo Iwano

    Asia Congress of Thoracic Imaging 2023  2023.6.17 

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    Event date: 2023.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Seoul   Country:Korea, Republic of  

  2. CT findings of the chest wall

    Iwano S, Ito R, Kamiya S, Naganawa S, Nakamura S, Chen-Yoshikawa TF

    2023.4.14 

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    Event date: 2023.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  3. I-131治療後シンチにおけるSPECT/CTの有用性

    岩野信吾

    第3回愛知甲状腺研究会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  4. 甲状腺癌に対する1-131内用療法におけるSPECT/CTの有用性 International conference

    岩野信吾

    第52回日本核医学会学術総会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  5. 同時多発肺癌に対する仮想3Dマージン法を用いた術前手術シミュレーションを行った2例 International conference

    岩野信吾 長縄慎二 横井香平 宇佐美範恭 北野真利子 川上賢一  岸本真理子

    第48回日本医学放射線学会秋季臨床大会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  6. 仮想気管支鏡ナビゲーションの精度

    岸本真理子 岩野信吾 北野真利子 川上賢一 長縄慎二

    日本放射線医学会第152回中部地方会 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜県   Country:Japan  

  7. 胸部3D-CTによる肺葉容積計測:全自動肺葉分割CADの精度

    岩野信吾 北野真利子 岸本真理子 川上賢一 長縄慎二 古池亘 松尾啓司

    日本放射線医学会第152回中部地方会 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  8. 同時多発肺癌に対する仮想3Dマージン法を用いた手術計画

    岩野信吾、長縄慎二、宇佐見範恭、横井香平

    第2回Advanced CT・MR研究会 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  9. FDG集積の低い充実型原発性肺癌の検討

    岩野信吾、加藤克彦、伊藤信嗣、土屋賢一、長縄慎二

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  10. 仮想気管支鏡CADの精度

    岩野信吾、古池亘、川上賢一、北野真利子、松尾啓司、長縄慎二

    岩野信吾、古池亘、川上賢一、北野真利子、松尾啓司、長縄慎二 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜市   Country:Japan  

  11. 仮想3Dマージン法による肺癌区域切除術の妥当性の検討 International conference

    岩野信吾、古池 亘、川上賢一、北野真利子、岸本真理子、長縄慎二、宇佐美範恭、横井香平

    日本放射線医学会第151回中部地方会  

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  12. 3D-CTによる肺気腫評価と肺癌術後合併症との相関

    川上賢一、岩野信吾、長縄慎二、橋本直純、長谷川好規、宇佐美範恭、横井香平

    日本放射線医学会第151回中部地方会 

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  13. 腎細胞癌のPET ― F-18 FDGとC-11メチオニンの比較

    腎細胞癌のPET ― F-18 FDGとC-11メチオニンの比較

    日本核医学会第74回中部地方会 

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    Event date: 2012.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  14. 腸管に著明な集積を来した骨シンチグラフィの1例

    大河内慶行、岩野信吾、二橋尚志、伊藤信嗣、小川 浩、安藤嘉朗、中根俊樹、山崎雅弘、太田尚寿、河合雄一、平野真希、古池 亘、岡田有美子、川上賢一、土屋賢一、長縄慎二、加藤克彦、阿部真治

    日本核医学会第70回中部地方会 

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    Event date: 2010.2

    Language:Japanese  

  15. 小型肺腺癌の造影ダイナミックCT所見と進達度との関係

    岩野信吾、古池 亘、松尾啓司、長縄慎二、下山芳江

    日本医学放射線学会第147回中部地方会 

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    Event date: 2010.2

    Language:Japanese  

    Country:Japan  

  16. Growth Rate of Periphera Lung Cancers using Semi-automated Volumetric CAD with Multi-slice CT. International conference

    2nd World Congress of Thoracic Imaging and Diagnosis in Chest Disease 

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    Event date: 2009.5

    Language:English  

  17. 仮想気管支鏡ナビゲーションを用いた経気管支肺生検:末梢型肺癌の診断能を左右する因子の解析

    第68回日本医学放射線学会総会 

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    Event date: 2009.4

    Language:Japanese  

    Country:Japan  

  18. コンピューター支援診断(CAD)による肺癌の3D容積測定

    第68回日本医学放射線学会総会 

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    Event date: 2009.4

    Language:Japanese  

    Country:Japan  

  19. Virtual bronchoscopy-guided transbronchial lung biopsy in the diagnosis of peripheral lung cancer

    ECR2009 

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    Event date: 2009.3

    Language:English  

  20. 胸腔内結石の1例

    伊藤真弥、岩野信吾、長縄慎二

    名古屋レントゲンカンファランス 

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    Event date: 2007.9

    Language:Japanese  

    Country:Japan  

  21. 18F-FDG-PETで集積亢進が見られた両側副腎結核

    加藤克彦、岩野信吾、松島正哉、駒田智大、小川 浩、久保田誠司、川井 恒、阿部真治、中野 智、西野正成、長縄慎二、西尾正美、池田 充

    日本核医学会第 65回中部地方会 

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    Event date: 2007.6

    Language:Japanese  

    Country:Japan  

  22. 5Contrast enhanced MR imaging of the brain using T1-FLAIR with BLADE compared with conventional spin echo sequence. International conference

    ISMRM/15Contrast 

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    Event date: 2007.5

    Language:English  

  23. Computer-aided diagnosis of lung canaer:Definition and detection of ground-glass opasity on high-resolution CT. International conference

    ECR2007 

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    Event date: 2007.3

    Language:English  

  24. 肺癌の類似CT画像検索CADの初期的検討

    岩野信吾, 岡田徹, 神岡祐子, 石垣武男, 長縄慎二

    日本医学放射線学会 

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    Event date: 2007

    Language:Japanese  

    Country:Japan  

  25. Comparison of 18F-FDG PET and bone scintigraphy in detection of bone metastases of thyroid cancer. International conference

    Annual congress of the European Association of Nuclear Medicine 

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    Event date: 2006.9

    Language:English  

  26. &sup1;&sup2;&sup3;I-IMP scintigraphy of malignant melanoma: comparison with &sup1;⁸F-FDG PET. International conference

    13th Workshop of the German-Japanese Radiological Affiliation 

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    Event date: 2006.3

    Language:English   Presentation type:Oral presentation (general)  

  27. 孤立性肺結節の良悪性コンピューター支援診断

    岩野信吾、中村達也、神岡祐子、岡田徹、石垣武男

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    Event date: 2006

    Language:Japanese  

    Country:Japan  

  28. Evaluation of Lymphoscintigraphy Taken after Bone Scinitigraphy. International conference

    Annual congress of the European Association of Nuclear Medicine 

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    Event date: 2005.10

    Language:English  

  29. &sup1;&sup2;&sup3;I-IMP scintigraphy of malignant melanoma : comparison with &sup1;⁸F-FDG PET. International conference

    Annual congress of the European Association of Nuclear Medicine 

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    Event date: 2005.10

    Language:English  

  30. Expertise in interactions of perceptual and conceptual processing. International conference

    27th Annual Conference of the Conbnitive Science Society 

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    Event date: 2005.7

    Language:English  

  31. Diagnostic value of curved multiplanar reformatted images in multislice CT for the detection of resectable pancreatic ductal adenocarcinoma. International conference

    16th annual meeting and postgraduate course ESGAR 2005 

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    Event date: 2005.5

    Language:English  

  32. Computer-aided diagnosis: a shape classification of pulmonary nodules imaged by high-resolution CT. International conference

    17th European Congress of Radiology 

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    Event date: 2005.3

    Language:English  

  33. Branch duct-type intraductal papillary mucinous tumor: diagnostic value of multiplanar reformatted images in multislice CT. International conference

    16th European Congress of Radiology 

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    Event date: 2004.3

    Language:English  

  34. Computer-aided diagnosis: a shape classification of pulmonary nodules imaged by high-resolution CT. International conference

    16th European Congress of Radiology 

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    Event date: 2004.3

    Language:English  

  35. Evaluation of Lymphoscintigraphy Used Together with Bone Scintigraphy. International conference

    16th European Congress of Radiology 

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    Event date: 2004.3

    Language:English  

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KAKENHI (Grants-in-Aid for Scientific Research) 16

  1. Simulation of past and future images of lung cancer by virtual high-resolution CT using artificial intelligence

    Grant number:22K07692  2022.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

  2. 超高精細形態画像と機能画像の統合解析による早期肺癌の次世代予後予測モデルの確立

    Grant number:19K08149  2019.4 - 2024.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    岩野 信吾, 中村 彰太, 伊藤 信嗣, 伊藤 倫太郎

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    原発性肺癌の臨床病期分類は胸部CTに様々な画像検査を組み合わせて決定され、最適な治療方針を決定する基盤情報である。しかし限られた空間分解能による形態診断の限界により病理病期分類との間に差を生じることがある。本研究では肺癌症例の膨大な画像・手術・病理データを活用し、浸潤性・予後に関連する超高精細CT、MRI、PETによる新たなバイオマーカー構築を探索し、これらを統合的に解析することで早期肺癌の予後予測の精度向上、次世代の肺癌病期分類改訂に貢献する。
    本研究では、肺癌症例の膨大な画像・手術・病理データを活用し、浸潤性・予後に関連する超高精細CT、MRI、PETによる新たなバイオマーカー構築を探索し、これらを統合的に解析することで早期肺癌の予後予測の精度向上、次世代の肺癌病期分類改訂に貢献することを目的としている。
    名古屋大学医学部附属病院に超高精細CTが導入された2019年11月から2022年4月にかけて肺癌症例の超高精細CTを収集した。令和4年度はれまでの画像診断では診断が難しかった胸壁浸潤癌についてその超高精細CT画像所見を検討するため、胸膜・胸壁と接する77症例を選択し、その超高精細CT所見を検討した。その結果、胸壁に存在する肋間動脈由来の血管が腫瘍に分布する所見が認められた場合、胸壁浸潤癌である可能性が高いことを見いだした。この結果を2023年2月に開催された日本医学放射線学会第172回中部地方会で報告した。
    またPET/CT、従来型高精細CT、マイクロCTについて画像・臨床データベースから抽出し、それらがTNM分類や予後に与える影響についてレトロスペクティブな解析を行っている。
    Deep Learningを研究手法に取り入れ、5mm厚のcovnentional CT画像から0.6mm厚の高精細3次元CT画像を再構成する人工知能(AI)を開発した。このAIを使うと原発性肺癌のTNM分類のT因子に採用されている充実成分径について、空間分解能の低い5mm厚のCT画像においても高精細CT並みに計測できることを明らかにした。本研究の原著論文について英文雑誌に投稿中である。
    超高精細CTによる胸壁浸潤癌の診断についてデータ収集が終了し、解析結果を第14回呼吸機能イメージング研究会、日本医学放射線学会第172回中部地方会、第82回日本医学放射線学会総会で口演発表を行った。
    名古屋大学医学部附属病院に設置された超高精細CTにより肺癌症例の収集は順調に進んでいるが、もともと胸壁浸潤癌の頻度が低いのでその症例収集が当初の見込みより遅れてしまった。しかし2022年4月末までに目標症例数に到達したため、結果の解析を進めている。令和5年度中に研究成果を発表できる見込みである。
    COVID-19の世界的流行に伴い、国内・海外学会が軒並み中止・延期もしくはオンライン開催となってしまったため、学会発表について十分に行えておらず、他の研究者とのディスカッションが不十分である。
    2021年度以降はDeep Learningを研究手法に取り入れ、5mm厚のcovnentional CT画像から0.6mm厚の高精細3次元CT画像を再構成する人工知能(AI)を開発した。このAIを使うと原発性肺癌のTNM分類のT因子に採用されている充実成分径について、空間分解能の低い5mm厚のCT画像においても高精細CT並みに計測できることを明らかにして、原著論文として英文雑誌に投稿中であり、2023年度中に受理されるように努力する。
    また2023年度中に肺癌の超高精細CTによる胸壁浸潤の診断について論文化を進める。すでに研究結果は出ているので2023年度中に論文として公開できる見通しである。
    COVID-19のパンデミックについて全世界で回復の兆しが見えており、学会活動が回復していくと思われるので積極的に学会に参加して研究成果の発表と研究者たちとのディスカッションを行う予定である。

  3. Development of integrated computer-aided diagnosis system for various lung diseases using 3D-CT images

    Grant number:17H02110  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KIDO SHOJI

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    Authorship:Coinvestigator(s) 

    We have developed computer-aided diagnosis (CAD) system that is more accurate and robust than the conventional CAD methods on high-resooution 3D images obtained from multi-detector row CT system for various lung diseases by use of deep learning technology.
    For diffuse lung diseases, we extracted abnormal regions from each opacity pattern using U-Net and Residual U-Net. Nd, also we classified diffuse lung opacity patterns by use of unsupervised learning which does not require annotations by radiologists. For lung nodules, region extraction was performed three-dimensionally using DeconvNet and V-Net. In all cases, good results were obtained, which were in good agreement with the annotations by the radiologists.

  4. 超高精細胸壁並行断面CTと人工知能によるびまん性肺疾患のコンピュータ支援診断

    2017.4 - 2019.3

    科学研究費補助金  新学術領域研究

    岩野信吾

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    Authorship:Principal investigator 

  5. 超高精細胸壁並行断面CTと人工知能によるびまん性肺疾患のコンピュータ支援診断

    Grant number:17H05292  2017.4 - 2019.3

    日本学術振興会  科学研究費助成事業  新学術領域研究(研究領域提案型)

    岩野 信吾

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    Authorship:Principal investigator 

    Grant amount:\3380000 ( Direct Cost: \2600000 、 Indirect Cost:\780000 )

    びまん性肺疾患とは、胸部X線CT画像上、両肺にびまん性陰影を認め、主に肺胞隔壁(間質)を病変の場とする間質性肺疾患の総称である。従来のびまん性肺疾患の画像診断は、軸位断CT画像の放射線科医による視覚的評価が主体であり、軸位断像のため頭尾方向への病変の広がりが認識しにくく、主観的評価のため読影者間の不一致率が高いことが問題であった。
    研究代表者はびまん性肺疾患の病変が胸壁直下に好発する点に着目し、胸部3次元CT(3D-CT)画像データから、胸壁より一定の深さ(1cm, 2 cm, ...)で胸壁に並行な曲面のcurved MPR像を再構成すれば、全肺の肺病変を1画像に表示することが可能になると考え、胸壁並行断面CT(3D -curved high-resoution CT;3D-cHRCT)を開発した。
    3D-cHRCTでは、これまで2次元の軸位断画像でしか診断できなかったびまん性肺疾患の肺内における3次元的な分布を1画像に表現することが可能である。H29年度には3D-cHRCTにより間質性肺炎と肺気腫の定量評価が可能かどうかを検討し、3D-cHRCTから計算されるそれぞれの定量値は、びまん性肺疾患臨床的病勢評価と有意に相関していることを明らかにした。H30年度にはこの成果を発展させて、3D-cHRCTにより特発性間質性肺炎の経時的変化を定量的に評価できないかを検討した。結果として、3D-cHRCTは間質性肺炎の病勢悪化を反映し、スパイロメトリーで計測した肺活量・肺拡散能の経時変化と相関することを明らかにした。本研究成果は原著論文として国際雑誌 "Nagoya Journal of Medical Science"に掲載された。
    平成30年度が最終年度であるため、記入しない。
    平成30年度が最終年度であるため、記入しない。

  6. Development of computer-assisted diagnosis of thoracic diseases using a large scale 3D-CT image database

    Grant number:15K09919  2015.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Shingo Iwano

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    In this study, we developed a new CAD system that integrates chest 3D-CT and FDG-PET/CT images with medical information, and developed a new CAD system for the prognosis of primary lung cancer, and obtained the following four findings: 1) Accurate prognosis can be predicted by adding PET/CT quantitative data to CT images in the clinical staging of lung cancer; 2) Accurate prognosis can be predicted by 3D image analysis of Part-solid type lung cancer by CAD; 3) MTD (Metabolic Tumor Diameter) is developed as a new quantitative index of PET/CT, which is consistent with the staging of early stage lung cancer; 4) Ground-glass opacity on CT findings of lung cancer is related to prognosis.

  7. 大規模3次元CT画像データベースを利用した胸部疾患コンピュータ支援診断の開発

    2015.4 - 2019.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  8. 胸壁並行断面CT(オニオンスライスCT)による間質性肺炎のコンピュータ支援診断

    2015.4 - 2017.3

    科学研究費補助金  新学術領域研究

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    Authorship:Principal investigator 

  9. 胸壁並行断面CT(オニオンスライスCT)による間質性肺炎のコンピュータ支援診断

    Grant number:15H01115  2015.4 - 2017.3

    日本学術振興会  科学研究費助成事業 新学術領域研究(研究領域提案型)  新学術領域研究(研究領域提案型)

    岩野 信吾

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    特発性間質性肺炎とは、胸部X線CT画像上、両肺にびまん性陰影を認め、主に肺胞隔壁(間質)を病変の場とする原因不明の疾患の総称である。従来の間質性肺炎の画像診断は、軸位断CT画像の放射線科医による視覚的評価が主体であり、軸位断像のため頭尾方向への病変の広がりが認識しにくく、主観的評価のため読影者間の不一致率が高いことが問題であった。
    研究代表者は間質性肺炎病変が胸壁直下に好発する点に着目し、胸部3次元CT(3D-CT)画像データから、胸壁より一定の深さ(1cm, 2cm, ...)で胸壁に並行な曲面のcurved MPR像を再構成すれば、全肺の間質性肺炎病変を1画像で表示することが可能になると考え、3D-curved high-resoution CT; 3D-cHRCTを開発した。3D-cHRCTにより間質性肺炎の3次元的な分布を観察・診断することが可能となった。さらに前年度には3D-cHRCTによる間質性肺炎の定量評価が可能であることを明らかにした。
    本年度はこの3D-cHRCTを用いた間質性肺疾患の経過観察の可能性を検討した。結果として、3D-cHRCTから計算される定量値は、間質性肺疾患の放射線科医の画像診断的病勢評価および呼吸機能検査に基づく臨床的病勢評価と有意に相関していることが示された。このことは3D-cHRCTが、間質性肺疾患の新たな経過観察の指標になり得ることを示している。本研究成果については北米放射線学会(RSNA2016)において口演発表を行った。

  10. Evaluation of swallowing function after reconstruction surgery for orophayrngeal cancer using 320-Detector-Row Multislice CT.

    Grant number:26462601  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Fujimoto Yasushi, SHIMONO Mariko

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    Authorship:Coinvestigator(s) 

    Treatment strategy for oropharyngeal carcinoma have been confused in this decade. We tried to examine swallowing ability and mechanism of dysphagia after treatment of oropharyngeal carcinoma by 320lines MDCT system. We opted for Gehanno method and the suturing of the posterior pharyngeal wall to the base of the tongue after radical resection of oropharyngeal lateral wall. All patients could eat an oral diet without tube feeding. We caliculated pharyngeal constrictor ratio by video-fluorography, and could find good constriction of oropharyngeal wall after our reconstruction method. We also focused on the crosswise difference and distance between the tongue base and posterior wall of oropharynx. Among the cases of chemoradiotherapy, distance between tongue base and posterior wall tend to be longer, and the area around oropharynx were wider than normal. It may cause lower pharyngeal clearance rate. We are now planning further study for evaluate superiority of our reconstruction method.

  11. メニエール病におけるめまい発作発生機構の先端画像診断技術による解明

    2013.4 - 2017.3

    科学研究費補助金  基盤研究(B)

    長縄 慎二

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    Authorship:Coinvestigator(s) 

  12. 尿中ヨード濃度測定による分化型甲状腺癌に対する放射性ヨード内用療法の効果予測

    2013.4 - 2017.3

    科学研究費補助金  基盤研究(C)

    伊藤 信嗣

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    Authorship:Coinvestigator(s) 

  13. Elucidation of mechanism for the occurence of vertigo attacks in Meniere's disease by advanced diagnositic imaging techniques

    Grant number:25293263  2013.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Naganawa Shinji

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    Grant type:Competitive

    Meniere's disease is a benign disease whose symptom is a vertigo attack, but in reality it deprives the social life of so many people. There are still no definitive diagnostic methods and treatments yet. We have pioneered the development of the method and evaluation method for the endolymphatic hydrops of Meniere's disease by MRI and established the objective diagnostic method ahead of the world. A number of powerful estimation models have been proposed for several years. The purpose of this study was to explore the mechanism of occurrence of attacks by developing and applying advanced image technology, to evaluate the appropriateness of estimation model, and to contribute to the elucidation of the essence of vertigo occurrence mechanism of this disease. And with our research, we could almost identify the key finding correlating vertigo attacks. The keys are the saccular endolymphatic hydrops and impaired glymphatic function.

  14. Predictive value of radioiodine therapy for the patients of differentiated thyroid cancer by measuring the concentraion of urinary iodine

    Grant number:25461809  2013.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    ITO Shinji

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    Grant type:Competitive

    The purpose of this study is to clarify the influence of low iodine diets performed before the radioiodine therapy for the patients of differentiated thyroid cancer, through measuring the concentration of urinary iodine. There were no significant differences between the concentrations of urinary iodine of the two methods of low iodine diets: self-management low iodine diet and ready-made packaged strict low iodine diet. The outcome of radioiodine therapy was also not affected by the methods of low iodine diet. The standard self-managed low diet which were conducted in Japan is suggested to be appropriate for the preparation for the radioiodine therapy.

  15. 仮想3Dマージン法による早期肺癌区域切除術シミュレーションの臨床応用

    2012.4 - 2014.3

    科学研究費補助金  新学術領域研究(研究領域提案型)

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    Authorship:Principal investigator 

  16. 肺葉分割CADを用いたCOPD合併肺癌の術後肺機能予測

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 6

  1. ポリクリI

    2020

  2. PBLチュートリアル

    2020

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    PBLチュートリアル

  3. 放射線医学

    2020

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    胸部救急診断

  4. 現代医療と生命科学

    2020

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    最新CT診断

  5. 放射線医学

    2020

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    胸部画像診断

  6. ポリクリII

    2020

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