日本輸血・細胞療法学会

American Society of Hematology

European Hematology Association

小林がん学術振興会　先駆的研究賞

2012年   小林がん学術振興会  

日本白血病研究基金　一般研究賞

2000年   日本白血病研究基金  

武田科学振興財団　一般研究奨励賞

1999年   武田科学振興財団  

上原記念生命科学財団　研究奨励賞

1997年   上原記念生命科学財団  

Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment. 査読有り

Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T.

Blood   118 巻   頁： 1600-1609   2011年

KW-2449, a novel multi-kinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. 査読有り

Shiotsu Y*, Kiyoi H*, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T.

Blood   114 巻   頁： 1607-1617   2009年

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies 査読有り

Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Saito K, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Saito H, Ueda R, Ohno R, and Naoe T.

Blood   97 巻   頁： 2434-2439   2001年

Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. 査読有り

Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R.

Blood   93 巻   頁： 3074-3080   1999年

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. 査読有り

Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H, Naoe T.

Leukemia   12 巻   頁： 1333-1337   1998年

Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells 査読有り 国際誌

Kawashima Naomi, Ishikawa Yuichi, Kim Jeong Hui, Ushijima Yoko, Akashi Akimi, Yamaguchi Yohei, Hattori Hikaru, Nakashima Marie, Ikeno Seara, Kihara Rika, Nishiyama Takahiro, Morishita Takanobu, Watamoto Koichi, Ozawa Yukiyasu, Kitamura Kunio, Kiyoi Hitoshi

NATURE COMMUNICATIONS   13 巻 ( 1 ) 頁： 1624   2022年3月

Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma 査読有り 国際誌

Shimada Kazuyuki, Yoshida Kenichi, Suzuki Yasuhiro, Iriyama Chisako, Inoue Yoshikage, Sanada Masashi, Kataoka Keisuke, Yuge Masaaki, Takagi Yusuke, Kusumoto Shigeru, Masaki Yasufumi, Ito Takahiko, Inagaki Yuichiro, Okamoto Akinao, Kuwatsuka Yachiyo, Nakatochi Masahiro, Shimada Satoko, Miyoshi Hiroaki, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Shiozawa Yusuke, Nannya Yasuhito, Okabe Asako, Kohno Kei, Atsuta Yoshiko, Ohshima Koichi, Nakamura Shigeo, Ogawa Seishi, Tomita Akihiro, Kiyoi Hitoshi

BLOOD   137 巻 ( 11 ) 頁： 1491 - 1502   2021年3月

Allogeneic hematopoietic stem cell transplantation at the first remission for younger adults with<i>FLT3</i>-internal tandem duplication AML: The JALSG AML209-FLT3-SCT study 査読有り 国際誌

Kawashima, N; Ishikawa, Y; Atsuta, Y; Sawa, M; Ozawa, Y; Hayashi, M; Kohno, A; Tomita, A; Maeda, T; Sakaida, E; Usuki, K; Hagihara, M; Kanamori, H; Matsuoka, H; Kobayashi, M; Asou, N; Ohtake, S; Matsumura, I; Miyazaki, Y; Naoe, T; Kiyoi, H

CANCER SCIENCE   111 巻 ( 7 ) 頁： 2472 - 2481   2020年7月

Simple and early prediction of severe CAR-T-related adverse events after Axi-cel infusion by initial high fever. 査読有り 国際誌

Wakabayashi H, Terakura S, Ishigiwa K, Ohara F, Hirano S, Yokota H, Kuwano S, Furukawa K, Shimada K, Sato T, Hanajiri R, Kiyoi H

International journal of hematology     2025年2月

Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): long-term results of a multicentre, single-arm, phase 2 trial 査読有り 国際誌

Shimada, K; Yamaguchi, M; Kuwatsuka, Y; Matsue, K; Sato, K; Kusumoto, S; Nagai, H; Takizawa, J; Fukuhara, N; Nagafuji, K; Miyazaki, K; Ohtsuka, E; Okamoto, A; Sugita, Y; Uchida, T; Kayukawa, S; Wake, A; Ennishi, D; Kondo, Y; Meguro, A; Kin, Y; Minami, Y; Hashimoto, D; Nishiyama, T; Shimada, S; Masaki, Y; Okamoto, M; Atsuta, Y; Kiyoi, H; Suzuki, R; Nakamura, S; Kinoshita, T; Ennishi, D; Kondo, Y; Meguro, A; Kin, Y; Minami, Y; Hashimoto, D; Nishiyama, T; Shimada, S; Masaki, Y; Okamoto, M; Atsuta, Y; Kiyoi, H; Suzuki, R; Nakamura, S; Kinoshita, T

ECLINICALMEDICINE   80 巻   頁： 103078   2025年2月

Post-transplant TKIs for Ph+ ALL: practices to date and clinical significance. 査読有り 国際誌

Nishiwaki S, Terakura S, Morishita T, Goto T, Inagaki Y, Miyao K, Fukushima N, Hirano D, Tange N, Kurahashi S, Kuwatsuka Y, Kasai M, Iida H, Ozeki K, Sawa M, Nishida T, Kiyoi H

International journal of hematology     2025年1月

Sustained inhibition of CSF1R signaling augments antitumor immunity through inhibiting tumor-associated macrophages 査読有り 国際誌

Sato, T; Sugiyama, D; Koseki, J; Kojima, Y; Hattori, S; Sone, K; Nishinakamura, H; Ishikawa, T; Ishikawa, Y; Kato, T; Kiyoi, H; Nishikawa, H

JCI INSIGHT   10 巻 ( 1 )   2025年1月

Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway 査読有り 国際共著 国際誌

Adachi, Y; Terakura, S; Osaki, M; Okuno, Y; Sato, Y; Sagou, K; Takeuchi, Y; Yokota, H; Imai, K; Steinberger, P; Leitner, J; Hanajiri, R; Murata, M; Kiyoi, H

NATURE COMMUNICATIONS   15 巻 ( 1 ) 頁： 10376   2024年12月

Nelarabine-combined chemotherapy improves outcome of T-cell acute lymphoblastic leukemia but shows more severe neurotoxicity: JALSG T-ALL213-O 査読有り 国際誌

Hayakawa, F; Mori, N; Imai, K; Yokoyama, Y; Katsuoka, Y; Saito, T; Murayama, T; Yamazaki, E; Sato, S; Atsuta, Y; Ishikawa, Y; Sakaida, E; Hatta, Y; Matsumura, I; Miyazaki, Y; Kiyoi, H

CANCER SCIENCE     2024年11月

Clinical characteristics in adolescents and young adults with polycythemia vera and essential thrombocythemia in Japan 査読有り 国際誌

Sugimoto, Y; Nagaharu, K; Ohya, E; Ohishi, K; Tawara, I; Ito, T; Gotoh, A; Nakamae, M; Kimura, F; Koike, M; Kirito, K; Wada, H; Usuki, K; Tanaka, T; Mori, T; Wakita, S; Saito, TI; Saito, AM; Shimoda, K; Kurokawa, T; Tomita, A; Edahiro, Y; Hashimoto, Y; Kiyoi, H; Akashi, K; Matsumura, I; Takenaka, K; Komatsu, N

INTERNATIONAL JOURNAL OF HEMATOLOGY   120 巻 ( 6 ) 頁： 684 - 693   2024年10月

Misleading antigenic von Willebrand factor levels in acquired von Willebrand syndrome secondary to monoclonal gammopathy of undetermined significance 査読有り 国際誌

Okamoto, S; Suzuki, A; Tamura, S; Suzuki, N; Kanematsu, T; Suzuki, N; Kawaguchi, Y; Katsumi, A; Hayakawa, F; Kiyoi, H; Kojima, T; Matsushita, T

INTERNATIONAL JOURNAL OF HEMATOLOGY     2024年10月

Spheroid culture to select theoretical therapeutic drugs in intravascular large B-cell lymphoma 査読有り 国際誌

Takai, M; Shimada, K; Furukawa, K; Yamaga, Y; Yoshiyama, S; Kagaya, Y; Suzuki, T; Hayashi, K; Shimada, S; Karube, K; Kiyoi, H

CANCER SCIENCE     2024年10月

Newly diagnosed multiple myeloma with bleeding and coagulation abnormalities caused by a thrombin-inhibiting substance 査読有り 国際誌

Ohara, F; Suzuki, A; Suzuki, N; Kanematsu, T; Okamoto, S; Tamura, S; Kiyoi, H; Matsushita, T; Katsumi, A

INTERNATIONAL JOURNAL OF HEMATOLOGY     2024年9月

Recent advances in AML with mutated <i>NPM1</i> 招待有り 査読有り 国際誌

Ishikawa, Y; Ushijima, Y; Kiyoi, H

INTERNATIONAL JOURNAL OF HEMATOLOGY     2024年8月

Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis (JUL, 10.1007/s00277-024-05898-3, 2024) 査読有り 国際誌

Nagaharu, K; Ohya, E; Edahiro, Y; Hashimoto, Y; Ito, T; Gotoh, A; Nakamae, M; Kimura, F; Koike, M; Kirito, K; Wada, H; Usuki, K; Tanaka, T; Mori, T; Wakita, S; Saito, TI; Saito, AM; Shimoda, K; Kurokawa, T; Tomita, A; Kiyoi, H; Akashi, K; Matsumura, I; Takenaka, K; Komatsu, N; Ohishi, K; Tawara, I; Sugimoto, Y

ANNALS OF HEMATOLOGY     2024年8月

Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis 査読有り 国際誌

Nagaharu, K; Ohya, E; Edahiro, Y; Hashimoto, Y; Ito, T; Gotoh, A; Nakamae, M; Kimura, F; Koike, M; Kirito, K; Wada, H; Usuki, K; Tanaka, T; Mori, T; Wakita, S; Saito, TI; Saito, AM; Shimoda, K; Kurokawa, T; Tomita, A; Kiyoi, H; Akashi, K; Matsumura, I; Takenaka, K; Komatsu, N; Ohishi, K; Tawara, I; Sugimoto, Y

ANNALS OF HEMATOLOGY   103 巻 ( 9 ) 頁： 3535 - 3541   2024年7月

Initiating-clone analysis in patients with acute myeloid leukemia secondary to essential thrombocythemia 査読有り 国際誌

Ushijima, Y; Naruse, S; Ishikawa, Y; Kawashima, N; Sanada, M; Nakashima, M; Kim, JH; Terakura, S; Kihara, R; Watamoto, K; Nishiyama, T; Kitamura, K; Matsushita, T; Kiyoi, H

SCIENTIFIC REPORTS   14 巻 ( 1 ) 頁： 15906   2024年7月

Nilotinib vs. Dasatinib in Achieving MR4.5 for de novo Chronic Myeloid Leukemia: the Randomized JALSG CML212 Study. 査読有り 国際誌

Matsumura I, Ohtake S, Atsuta Y, Kurata M, Minami Y, Takahashi N, Nakaseko C, Iriyama N, Fujimaki K, Kakihana K, Ogasawara Y, Ono T, Okada M, Tauchi T, Miyamoto T, Ohnishi K, Sakaida E, Fujisawa S, Kobayashi Y, Asou N, Naoe T, Kiyoi H, Miyazaki Y

Blood advances     2024年7月

NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation 査読有り 国際誌

Noura, M; Tomita, S; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

CANCER MEDICINE   13 巻 ( 13 ) 頁： e7445   2024年7月

<i>RGS1</i> and <i>CREB5</i> are direct and common transcriptional targets of ZNF384-fusion proteins 査読有り 国際誌

Yamada, C; Okada, K; Odaira, K; Tokoro, M; Iwamoto, E; Sanada, M; Noura, M; Okamoto, S; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

CANCER MEDICINE   13 巻 ( 14 ) 頁： e7471   2024年7月

Human iPSC-derived CD4+Treg-like cells engineered with chimeric antigen receptors control GvHD in a xenograft model 査読有り 国際誌

Yano, H; Koga, K; Sato, T; Shinohara, T; Iriguchi, S; Matsuda, A; Nakazono, K; Shioiri, M; Miyake, Y; Kassai, Y; Kiyoi, H; Kaneko, S

CELL STEM CELL   31 巻 ( 6 ) 頁： 795 - 802.e6   2024年6月

Phase II study in children and adults under 40 years with newly diagnosed Langerhans cell histiocytosis: protocol for an LCH-19-MSMFB clinical trial in Japan 査読有り 国際誌

Ono, R; Sakamoto, K; Kudo, K; Sato, A; Kudo, K; Fujino, H; Kawahara, Y; Hashimoto, H; Doi, T; Yanagisawa, R; Kawamata, T; Miyazaki, O; Nakazawa, A; Ota, Y; Kanegane, H; Nakazawa, Y; Horibe, K; Saito, AM; Manabe, A; Usuki, K; Kiyoi, H; Morimoto, A; Tojo, A; Shioda, Y

BMJ OPEN   14 巻 ( 6 ) 頁： e084159   2024年6月

Clonal evolution process from essential thrombocythemia to acute myeloid leukemia in the original patient from whom the CALR-mutated Marimo cell line was established. 査読有り 国際誌

Ushijima Y, Ishikawa Y, Nishiyama T, Kawashima N, Kanamori T, Sanada M, Kiyoi H

Nagoya journal of medical science   86 巻 ( 2 ) 頁： 326 - 332   2024年5月

A phase 1/2 study of NS-87/CPX-351 (cytarabine and daunorubicin liposome) in Japanese patients with high-risk acute myeloid leukemia 査読有り 国際誌

Usuki, K; Miyamoto, T; Yamauchi, T; Ando, K; Ogawa, Y; Onozawa, M; Yamauchi, T; Kiyoi, H; Yokota, A; Ikezoe, T; Katsuoka, Y; Takada, S; Aotsuka, N; Morita, Y; Ishikawa, T; Asada, N; Ota, S; Dohi, A; Morimoto, K; Imai, S; Kishimoto, U; Akashi, K; Miyazaki, Y

INTERNATIONAL JOURNAL OF HEMATOLOGY   119 巻 ( 6 ) 頁： 647 - 659   2024年3月

Novel CSF1R inhibitor, FF-10101, strongly inhibit tumor-associated macrophages and improve anti-tumor response 査読有り 国際誌

Sato, T; Sugiyama, D; Kojima, Y; Hattori, S; Sone, K; Ishikawa, Y; Nishikawa, H; Kiyoi, H

CANCER SCIENCE   115 巻   頁： 41 - 41   2024年3月

Utility of allogeneic stem cell transplantation for adult Ph plus ALL with complete molecular remission 査読有り 国際誌

Nishiwaki, S; Sugiura, I; Fujisawa, S; Hatta, Y; Atsuta, Y; Doki, N; Kurahashi, S; Ueda, Y; Dobashi, N; Maeda, T; Matsumura, I; Tanaka, M; Kako, S; Ichinohe, T; Fukuda, T; Ohtake, S; Ishikawa, Y; Miyazaki, Y; Kiyoi, H

AMERICAN JOURNAL OF HEMATOLOGY     2024年2月

Suppression of super-enhancer-driven <i>TAL1</i> expression by KLF4 in T-cell acute lymphoblastic leukemia 査読有り 国際誌

Noura, M; Matsuo, H; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

ONCOGENE   43 巻 ( 6 ) 頁： 447 - 456   2024年2月

Real-world data of MDS and CMML in Japan: results of JALSG clinical observational study-11 (JALSG-CS-11) 査読有り 国際誌

Usuki, K; Ohtake, S; Honda, S; Matsuda, M; Wakita, A; Nawa, Y; Takase, K; Maeda, A; Sezaki, N; Yokoyama, H; Takada, S; Hirano, D; Tomikawa, T; Sumi, M; Yano, S; Handa, H; Ota, S; Fujita, H; Fujimaki, K; Mugitani, A; Kojima, K; Kajiguchi, T; Fujimoto, K; Asou, N; Usui, N; Ishikawa, Y; Katsumi, A; Matsumura, I; Miyazaki, Y; Kiyoi, H

INTERNATIONAL JOURNAL OF HEMATOLOGY   119 巻 ( 2 ) 頁： 130 - 145   2024年2月

Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation 査読有り 国際誌

Sagou, K; Sato, Y; Okuno, Y; Watanabe, T; Inagaki, T; Motooka, Y; Toyokuni, S; Murata, T; Kiyoi, H; Kimura, H

PLOS PATHOGENS   20 巻 ( 2 ) 頁： e1011954   2024年2月

Real-world data of AML in Japan: results of JALSG clinical observational study-11 (JALSG-CS-11) 査読有り 国際誌

Usuki, K; Ohtake, S; Honda, S; Matsuda, M; Wakita, A; Nawa, Y; Takase, K; Maeda, A; Sezaki, N; Yokoyama, H; Takada, S; Hirano, D; Tomikawa, T; Sumi, M; Yano, S; Handa, H; Ota, S; Fujita, H; Fujimaki, K; Mugitani, A; Kojima, K; Kajiguchi, T; Fujimoto, K; Asou, N; Usui, N; Ishikawa, Y; Katsumi, A; Matsumura, I; Kiyoi, H; Miyazaki, Y

INTERNATIONAL JOURNAL OF HEMATOLOGY   119 巻 ( 1 ) 頁： 24 - 38   2024年1月

Outcomes of transplant-eligible patients with myelodysplastic syndrome with excess blasts registered in an observational study: The JALSG-CS11-MDS-SCT 査読有り 国際誌

Nakagawa, N; Ishiyama, K; Usuki, K; Takada, S; Tomikawa, T; Handa, H; Katsuoka, Y; Hirano, D; Sezaki, N; Sumi, M; Fujisawa, S; Taniguchi, Y; Mugitani, A; Yoshimura, T; Ohtsuka, E; Takase, K; Suehiro, Y; Ota, S; Kajiguchi, T; Maeda, T; Yamamoto, M; Ohtake, S; Katsumi, A; Kiyoi, H; Matsumura, I; Miyazaki, Y

ANNALS OF HEMATOLOGY   103 巻 ( 1 ) 頁： 307 - 320   2024年1月

Clonal hematopoiesis of a novel dic(18;20) clone following allogeneic hematopoietic stem cell transplantation 査読有り 国際誌

Ito, M; Fukushima, N; Fujii, T; Numata, M; Morikawa, S; Kawamura, Y; Goto, M; Kohno, A; Imahashi, N; Yasuda, T; Sanada, M; Ishikawa, Y; Kiyoi, H; Ozeki, K

INTERNATIONAL JOURNAL OF HEMATOLOGY   119 巻 ( 1 ) 頁： 80 - 87   2024年1月

Dual CAR-T cells targeting CD19 and CD37 are effective in target antigen loss B cell tumor models. 査読有り

Imai K, Takeuchi Y, Terakura S, Okuno S, Adachi Y, Osaki M, Umemura K, Hanajiri R, Shimada K, Murata M, Kiyoi H

Molecular cancer therapeutics     2023年10月

Antibody response after third dose of COVID-19 mRNA vaccination in allogeneic hematopoietic stem cell transplant recipients is comparable to that in healthy counterparts 査読有り 国際誌

Takagi Erina, Terakura Seitaro, Fujigaki Hidetsugu, Okamoto Akinao, Miyao Kotaro, Sawa Masashi, Morishita Takanobu, Goto Tatsunori, Ozawa Yukiyasu, Nishida Tetsuya, Fukushima Nobuaki, Ozeki Kazutaka, Hanajiri Ryo, Saito Kuniaki, Murata Makoto, Tomita Akihiro, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   118 巻 ( 4 ) 頁： 462 - 471   2023年10月

Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation. 査読有り 国際誌

Kurayoshi K, Takase Y, Ueno M, Ohta K, Fuse K, Ikeda S, Watanabe T, Nishida Y, Horike SI, Hosomichi K, Ishikawa Y, Tadokoro Y, Kobayashi M, Kasahara A, Jing Y, Shoulkamy MI, Meguro-Horike M, Kojima K, Kiyoi H, Sugiyama H, Nagase H, Tajima A, Hirao A

Cell death & disease   14 巻 ( 9 ) 頁： 642   2023年9月

Improved long-term net survival after allogeneic hematopoietic cell transplantation in patients with hematologic malignancies over two decades. 査読有り 国際誌

Ohbiki M, Ito Y, Inamoto Y, Miyamura K, Uchida N, Fukuda T, Fujiwara H, Nishida T, Hayashi M, Tanaka M, Kawakita T, Ikegame K, Katayama Y, Ara T, Ichinohe T, Kiyoi H, Matsuo K, Atsuta Y

Transplantation and cellular therapy     2023年9月

Clinicopathological characteristics associated with the engraftment of patient lymphoma cells in NOG mice 査読有り 国際誌

Sahashi Satomi, Shimada Kazuyuki, Takagi Yusuke, Aoki Tomohiro, Kunou Shunsuke, Sakamoto Akihiko, Murase Atsushi, Furukawa Katsuya, Kagaya Yusuke, Yamaga Yusuke, Takai Mika, Tokuyama Kiyonobu, Shimada Satoko, Nakamura Shigeo, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   118 巻 ( 2 ) 頁： 221 - 230   2023年8月

EBF1-JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity 査読有り 国際誌

Kojima Yukino, Kawashima Fumika, Yasuda Takahiko, Odaira Koya, Inagaki Yuichiro, Yamada Chiharu, Muraki Ami, Noura Mina, Okamoto Shuichi, Tamura Shogo, Iwamoto Eisuke, Sanada Masashi, Matsumura Itaru, Miyazaki Yasushi, Kojima Tetsuhito, Kiyoi Hitoshi, Tsuzuki Shinobu, Hayakawa Fumihiko

INTERNATIONAL JOURNAL OF HEMATOLOGY   118 巻 ( 1 ) 頁： 65 - 74   2023年7月

High-risk Combinations of Additional Chromosomal Abnormalities in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia: JALSG Ph plus ALL TKI-SCT Study

Nishiwaki Satoshi, Sugiura Isamu, Fujisawa Shin, Hatta Yoshihiro, Atsuta Yoshiko, Doki Noriko, Kurahashi Shingo, Ueda Yasunori, Dobashi Nobuaki, Maeda Tomoya, Taniguchi Yasuhiro, Tanaka Masatsugu, Kako Shinichi, Ichinohe Tatsuo, Fukuda Takahiro, Ohtake Shigeki, Ishikawa Yuichi, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

HEMASPHERE   7 巻 ( 6 ) 頁： e899   2023年6月

Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosedT-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group 査読有り 国際誌

Sato Atsushi, Hatta Yoshihiro, Imai Chihaya, Oshima Koichi, Okamoto Yasuhiro, Deguchi Takao, Hashii Yoshiko, Fukushima Takashi, Hori Toshinori, Kiyokawa Nobutaka, Kato Motohiro, Saito Shoji, Anami Kenichi, Sakamoto Tatsuhiro, Kosaka Yoshiyuki, Suenobu Souichi, Imamura Toshihiko, Kada Akiko, Saito Akiko M., Manabe Atsushi, Kiyoi Hitoshi, Matsumura Itaru, Koh Katsuyoshi, Watanabe Arata, Miyazaki Yasushi, Horibe Keizo

LANCET HAEMATOLOGY   10 巻 ( 6 ) 頁： 419 - 432   2023年6月

Autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia is safe but poses challenges for long-term maintenance of molecular remission: Results of the Auto-Ph17 study. 査読有り 国際誌

Nishiwaki S, Sugiura I, Sato T, Kobayashi M, Osaki M, Sawa M, Adachi Y, Okabe M, Saito S, Morishita T, Kohno A, Nishiyama T, Iida H, Kurahashi S, Kuwatsuka Y, Sugiyama D, Ito S, Nishikawa H, Kiyoi H

EJHaem   4 巻 ( 2 ) 頁： 358 - 369   2023年5月

A never-ending FLT3 story 招待有り 査読有り 国際誌

Kiyoi, H

NAGOYA JOURNAL OF MEDICAL SCIENCE   85 巻 ( 1 ) 頁： 27 - 29   2023年2月

BCL6 inhibition ameliorates resistance to ruxolitinib in <i>CRLF2</i>-rearranged acute lymphoblastic leukemia 査読有り 国際誌

Tsuzuki Shinobu, Yasuda Takahiko, Goto Hiroaki, Maeda Naoko, Akahane Koshi, Inukai Takeshi, Yamamoto Hideyuki, Karnan Sivasundaram, Ota Akinobu, Hyodo Toshinori, Konishi Hiroyuki, Hosokawa Yoshitaka, Kiyoi Hitoshi, Hayakawa Fumihiko

HAEMATOLOGICA   108 巻 ( 2 ) 頁： 394 - 408   2023年2月

The usefulness of tranexamic acid for bleeding symptoms of chronic consumptive coagulopathy complicated by aortic disease: a single-institute, retrospective study of 14 patients 査読有り 国際誌

Suzuki Naruko, Suzuki Nobuaki, Kawaguchi Yuka, Okamoto Shuichi, Kanematsu Takeshi, Katsumi Akira, Suzuki Atsuo, Tamura Shogo, Kojima Tetsuhito, Kiyoi Hitoshi, Matsushita Tadashi

THROMBOSIS JOURNAL   21 巻 ( 1 ) 頁： 10   2023年1月

[Cellular kinetics and outcome of tisagenlecleucel for diffuse large B-cell lymphoma]. 査読有り

Hanajiri R, Furukawa K, Nakashima M, Ushijima Y, Shimada K, Ishikawa Y, Terakura S, Murata M, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology   64 巻 ( 3 ) 頁： 167 - 174   2023年

Functional inhibition of MEF2 by C/EBP is a possible mechanism of leukemia development by CEBP-IGH fusion gene 査読有り 国際誌

Odaira Koya, Yasuda Takahiko, Okada Kentaro, Shimooka Takuya, Kojima Yukino, Noura Mina, Tamura Shogo, Kurahashi Shingo, Iwamoto Eisuke, Sanada Masashi, Matsumura Itaru, Miyazaki Yasushi, Kojima Tetsuhito, Kiyoi Hitoshi, Tsuzuki Shinobu, Hayakawa Fumihiko

CANCER SCIENCE   114 巻 ( 3 ) 頁： 781 - 792   2022年11月

Methods for confirming the safety of radiation therapy in patients with left ventricular assist device: a case of extranodal NK/T-cell lymphoma, nasal type 査読有り 国際誌

Oishi Hideo, Kondo Toru, Kawamura Mariko, Shimada Kazuyuki, Mutsuga Masato, Kurokawa Takashi, Kuwayama Tasuku, Hiraiwa Hiroaki, Morimoto Ryota, Okumura Takahiro, Nishida Tetsuya, Kiyoi Hitoshi, Naganawa Shinji, Usui Akihiko, Murohara Toyoaki

JOURNAL OF ARTIFICIAL ORGANS   25 巻 ( 3 ) 頁： 274 - 278   2022年9月

Prospective comparison of 5-and 7-day administration of azacitidine for myelodysplastic syndromes: a JALSG MDS212 trial 査読有り 国際誌

Miyazaki Yasushi, Kiguchi Toru, Sato Shinya, Usuki Kensuke, Ishiyama Ken, Ito Yoshikazu, Suzuki Takahiro, Taguchi Jun, Chiba Shigeru, Dobashi Nobuaki, Tomita Akihiro, Harada Hironori, Handa Hiroshi, Horiike Shigeo, Maeda Tomoya, Matsuda Mitsuhiro, Ichikawa Motoshi, Hata Tomoko, Honda Sumihisa, Iyama Satoshi, Suzushima Hitoshi, Moriuchi Yukiyoshi, Kurokawa Toshiro, Yokota Kenichi, Ohtake Shigeki, Yamauchi Takahiro, Matsumura Itaru, Kiyoi Hitoshi, Naoe Tomoki

INTERNATIONAL JOURNAL OF HEMATOLOGY   116 巻 ( 2 ) 頁： 228 - 238   2022年8月

VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation 査読有り 国際誌

Okamoto Shuichi, Tamura Shogo, Sanda Naomi, Odaira Koya, Hayakawa Yuri, Mukaide Masato, Suzuki Atsuo, Kanematsu Takeshi, Hayakawa Fumihiko, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi, Suzuki Nobuaki

JOURNAL OF THROMBOSIS AND HAEMOSTASIS   20 巻 ( 8 ) 頁： 1784 - 1796   2022年8月

Real-world treatment patterns and clinical outcomes in patients with AML in Japan who were ineligible for first-line intensive chemotherapy 査読有り 国際共著 国際誌

Yoshida Chikashi, Kondo Takeshi, Ito Tomoki, Kizaki Masahiro, Yamamoto Kazuhiko, Miyamoto Toshihiro, Morita Yasuyoshi, Eto Tetsuya, Katsuoka Yuna, Takezako Naoki, Uoshima Nobuhiko, Imada Kazunori, Ando Jun, Komeno Takuya, Mori Akio, Ishikawa Yuichi, Satake Atsushi, Watanabe Junichi, Kawakami Yoshiko, Morita Tetsuo, Taneike Ikue, Nakayama Masahiko, Duan Yinghui, Garbayo Guijarro Belen, Delgado Alexander, Llamas Cynthia, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   116 巻 ( 1 ) 頁： 89 - 101   2022年7月

Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases 査読有り 国際共著 国際誌

Dai Yu-Ting, Zhang Fan, Fang Hai, Li Jian-Feng, Lu Gang, Jiang Lu, Chen Bing, Mao Dong-Dong, Liu Yuan-Fang, Wang Jin, Peng Li-Jun, Feng Chong, Chen Hai-Feng, Mu Jun-Xi, Zhang Qun-Ling, Wang Hao, Ariffin Hany, Moy Tan Ah, Wang Jing-Han, Lou Yin-Jun, Chen Su-Ning, Wang Qian, Liu Hong, Shan Zhe, Matsumura Itaru, Miyazaki Yasushi, Yasuda Takahiko, Dou Li-Ping, Yan Xiao-jing, Yan Jin-Song, Yeoh Allen Eng-Juh, Wu De-Pei, Kiyoi Hitoshi, Hayakawa Fumihiko, Jin Jie, Wang Sheng-Yue, Sun Xiao-Jian, Mi Jian-Qing, Chen Zhu, Huang Jin-Yan, Chen Sai-Juan

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   119 巻 ( 15 ) 頁： e2120787119   2022年4月

Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations 査読有り 国際誌

Yasuda Takahiko, Sanada Masashi, Kawazu Masahito, Kojima Shinya, Tsuzuki Shinobu, Ueno Hiroo, Iwamoto Eisuke, Iijima-Yamashita Yuka, Yamada Tomomi, Kanamori Takashi, Nishimura Rieko, Kuwatsuka Yachiyo, Takada Satoru, Tanaka Masatsugu, Ota Shuichi, Dobashi Nobuaki, Yamazaki Etsuko, Hirose Asao, Murayama Tohru, Sumi Masahiko, Sato Shinya, Tange Naoyuki, Nakamura Yukinori, Katsuoka Yuna, Sakaida Emiko, Kawamata Toyotaka, Iida Hiroatsu, Shiraishi Yuichi, Nannya Yasuhito, Ogawa Seishi, Taniwaki Masafumi, Asou Norio, Hatta Yoshihiro, Kiyoi Hitoshi, Matsumura Itaru, Horibe Keizo, Mano Hiroyuki, Naoe Tomoki, Miyazaki Yasushi, Hayakawa Fumihiko

BLOOD   139 巻 ( 12 ) 頁： 1850 - 1862   2022年3月

Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline 査読有り 国際誌

Iwama Shintaro, Kobayashi Tomoko, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Ando Masahiko, Zhou Xin, Yamagami Ayana, Onoue Takeshi, Kawaguchi Yohei, Miyata Takashi, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Wakahara Keiko, Yokota Kenji, Kato Masashi, Nishio Naoki, Tanaka Chie, Miyata Kazushi, Ogura Atsushi, Ito Takanori, Sawada Tsunaki, Shimokata Tomoya, Niimi Kaoru, Ohka Fumiharu, Ishigami Masatoshi, Gotoh Momokazu, Hashimoto Naozumi, Saito Ryuta, Kiyoi Hitoshi, Kajiyama Hiroaki, Ando Yuichi, Hibi Hideharu, Sone Michihiko, Akiyama Masashi, Kodera Yasuhiro, Arima Hiroshi

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   107 巻 ( 4 ) 頁： E1620 - E1630   2022年3月

Downregulation of HLA class II is associated with relapse after allogeneic stem cell transplantation and alters recognition by antigen-specific T cells 査読有り 国際誌

Adachi Yoshitaka, Sakai Toshiyasu, Terakura Seitaro, Shiina Takashi, Suzuki Shingo, Hamana Hiroshi, Kishi Hiroyuki, Sasazuki Takehiko, Arase Hisashi, Hanajiri Ryo, Goto Tatsunori, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   115 巻 ( 3 ) 頁： 371 - 381   2022年3月

Decision Analysis for Unrelated Bone Marrow Transplantation or Immediate Cord Blood Transplantation for Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Remission 査読有り 国際誌

Kako Shinichi, Hayakawa Fumihiko, Miyamura Koichi, Tanaka Junji, Imai Kiyotoshi, Kanda Junya, Morishima Satoko, Uchida Naoyuki, Doki Noriko, Ikegame Kazuhiro, Ozawa Yukiyasu, Takada Satoru, Usui Noriko, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Ichinohe Tatsuo, Fukuda Takahiro, Atsuta Yoshiko, Kanda Yoshinobu

TRANSPLANTATION AND CELLULAR THERAPY   28 巻 ( 3 ) 頁： 161.e1 - 161.e10   2022年3月

Immune effects of TKI altered immune responses after stopping TKI treatment and affected treatment-free remission rate 査読有り 国際誌

Fujioka Yuki, Takahashi Naoto, Atsuta Yoshiko, Minami Yosuke, Kiyoi Hitoshi, Miyazaki Yasushi, Matsumura Itaru

CANCER SCIENCE   113 巻   頁： 1712 - 1712   2022年2月

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia 査読有り 国際誌

Tsuzuki Shinobu, Yasuda Takahiko, Kawazu Masahito, Ueno Toshihide, Karnan Sivasundaram, Ota Akinobu, Sanada Masashi, Nagai Hirokazu, Tomita Akihiro, Takahashi Yoshiyuki, Miyazaki Yasushi, Matsumura Itaru, Kiyoi Hitoshi, Hosokawa Yoshitaka, Mano Hiroyuki, Hayakawa Fumihiko

CANCER SCIENCE   113 巻   頁： 1236 - 1236   2022年2月

Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia 査読有り 国際誌

Fujioka Yuki, Sugiyama Daisuke, Matsumura Itaru, Minami Yosuke, Miura Masatomo, Atsuta Yoshiko, Ohtake Shigeki, Kiyoi Hitoshi, Miyazaki Yasushi, Nishikawa Hiroyoshi, Takahashi Naoto

CANCERS   13 巻 ( 23 )   2021年12月

Optimal treatment for Philadelphia-negative acute lymphoblastic leukemia in first remission in the era of high-intensity chemotherapy 査読有り 国際誌

Kako Shinichi, Hayakawa Fumihiko, Imai Kiyotoshi, Tanaka Junji, Mizuta Shuichi, Nishiwaki Satoshi, Kanamori Heiwa, Mukae Junichi, Ozawa Yukiyasu, Kondo Tadakazu, Fukuda Takahiro, Ichinohe Tatsuo, Ota Shuichi, Tanaka Yoshinori, Murayama Tohru, Kurahashi Shingo, Sakura Toru, Usui Noriko, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Atsuta Yoshiko

INTERNATIONAL JOURNAL OF HEMATOLOGY   114 巻 ( 5 ) 頁： 608 - 619   2021年11月

Current progress and future perspectives of research on intravascular large B-cell lymphoma 招待有り 査読有り 国際誌

Shimada Kazuyuki, Kiyoi Hitoshi

CANCER SCIENCE   112 巻 ( 10 ) 頁： 3953 - 3961   2021年10月

Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival 査読有り 国際誌

Julamanee Jakrawadee, Terakura Seitaro, Umemura Koji, Adachi Yoshitaka, Miyao Kotaro, Okuno Shingo, Takagi Erina, Sakai Toshiyasu, Koyama Daisuke, Goto Tatsunori, Hanajiri Ryo, Hudecek Michael, Steinberger Peter, Leitner Judith, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

MOLECULAR THERAPY   29 巻 ( 9 ) 頁： 2677 - 2690   2021年9月

Efficacy and safety of blinatumomab: Post hoc pooled analysis in Asian adults with relapsed/refractory B-cell precursor acute lymphoblastic leukemia 査読有り 国際共著 国際誌

Kobayashi Yukio, Oh Iekuni, Miyamoto Toshihiro, Lee Won-Sik, Iida Hiroatsu, Minami Hironobu, Maeda Yoshinobu, Jang Jun Ho, Yoon Sung-Soo, Yeh Su-Peng, Tran Qui, Morris Joan, Franklin Janet, Kiyoi Hitoshi

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY     2021年6月

Spacer Length Modification Facilitates Discrimination between Normal and Neoplastic Cells and Provides Clinically Relevant CD37 CAR T Cells 査読有り 国際誌

Okuno Shingo, Adachi Yoshitaka, Terakura Seitaro, Julamanee Jakrawadee, Sakai Toshiyasu, Umemura Koji, Miyao Kotaro, Goto Tatsunori, Murase Atsushi, Shimada Kazuyuki, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

JOURNAL OF IMMUNOLOGY   206 巻 ( 12 ) 頁： 2862 - 2874   2021年6月

Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma 査読有り 国際誌

Kunou Shunsuke, Shimada Kazuyuki, Takai Mika, Sakamoto Akihiko, Aoki Tomohiro, Hikita Tomoya, Kagaya Yusuke, Iwamoto Eisuke, Sanada Masashi, Shimada Satoko, Hayakawa Fumihiko, Oneyama Chitose, Kiyoi Hitoshi

ONCOGENE   40 巻 ( 23 ) 頁： 3989 - 4003   2021年6月

Phase I clinical trial of intra-bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation 査読有り 国際誌

Goto Tatsunori, Murata Makoto, Nishida Tetsuya, Terakura Seitaro, Kamoshita Sonoko, Ishikawa Yuichi, Ushijima Yoko, Adachi Yoshiya, Suzuki Satoshi, Kato Katsuyoshi, Hirakawa Akihiro, Nishiwaki Satoshi, Nishio Nobuhiro, Takahashi Yoshiyuki, Kodera Yoshihisa, Matsushita Tadashi, Kiyoi Hitoshi

STEM CELLS TRANSLATIONAL MEDICINE   10 巻 ( 4 ) 頁： 542 - 553   2021年4月

Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group 査読有り 国際誌

Saito Takeshi, Hatta Yoshihiro, Hayakawa Fumihiko, Takahashi Tsutomu, Hagihara Maki, Iida Hiroatsu, Minauchi Koichiro, Yamazaki Etsuko, Sugiura Isamu, Murayama Tohru, Sakura Toru, Mori Naoki, Imai Kiyotoshi, Yahagi Yuichi, Atsuta Yoshiko, Saito Akiko Moriya, Hirakawa Akihiro, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

INTERNATIONAL JOURNAL OF HEMATOLOGY   113 巻 ( 3 ) 頁： 395 - 403   2021年3月

Machine learning-aided risk stratification in Philadelphia chromosome-positive acute lymphoblastic leukemia

Nishiwaki Satoshi, Sugiura Isamu, Koyama Daisuke, Ozawa Yukiyasu, Osaki Masahide, Ishikawa Yuichi, Kiyoi Hitoshi

BIOMARKER RESEARCH   9 巻 ( 1 ) 頁： 13   2021年2月

Impact of variation in reagent combinations for one-stage clotting assay on assay discrepancy in nonsevere haemophilia A 査読有り 国際誌

Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Okamoto Shuichi, Tamura Shogo, Kikuchi Ryosuke, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY   43 巻 ( 1 ) 頁： 131 - 138   2021年2月

<i>Myh9</i> R702C is associated with erythroid abnormality with splenomegaly in mice 査読有り 国際誌

Kanematsu, T; Suzuki, N; Tamura, S; Suzuki, A; Ishikawa, Y; Katsumi, A; Kiyoi, H; Saito, H; Kunishima, S; Kojima, T; Matsushita, T

NAGOYA JOURNAL OF MEDICAL SCIENCE   83 巻 ( 1 ) 頁： 75 - 86   2021年2月

Exosomes derived from cancer associated fibroblasts induce a resistance to histone deacetylase inhibitors in lymphoma 査読有り 国際誌

Kagaya Yusuke, Shimada Kazuyuki, Kunou Shunsuke, Hikita Tomoya, Sakamoto Akihiko, Hayakawa Fumihiko, Oneyama Chitose, Kiyoi Hitoshi

CANCER SCIENCE   112 巻   頁： 370 - 370   2021年2月

Research on FLT3 mutations and targeted therapeutics 招待有り 国際誌

Naoe Tomoki, Kiyoi Hitoshi, Yokota Shohei

CANCER SCIENCE   112 巻   頁： 1016 - 1016   2021年2月

A case of reexpansion pulmonary edema and acute pulmonary thromboembolism associated with diffuse large B-cell lymphoma treated with venovenous extracorporeal membrane oxygenation. 査読有り 国際誌

Kazama S, Hiraiwa H, Kimura Y, Ozaki R, Shibata N, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Kondo T, Furusawa K, Morimoto R, Okumura T, Bando YK, Sato T, Shimada K, Kiyoi H, Nakamura G, Yasuda Y, Kasugai D, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Goto Y, Matsuda N, Murohara T

Journal of cardiology cases   23 巻 ( 1 ) 頁： 53 - 56   2021年1月

Bursitis, Bacteremia, and Disseminated Infection of Mycobacteroides (Mycobacterium) abscessus subsp. massiliense 査読有り 国際誌

Oka Keisuke, Morioka Hiroshi, Eguchi Motoki, Sato Yoshitaka, Tetsuka Nobuyuki, Iguchi Mitsutaka, Kanematsu Takeshi, Fukano Hanako, Hoshino Yoshihiko, Kiyoi Hitoshi, Yagi Tetsuya

INTERNAL MEDICINE   60 巻 ( 18 ) 頁： 3041 - 3045   2021年

Predictors of early death, serious hemorrhage, and differentiation syndrome in Japanese patients with acute promyelocytic leukemia 査読有り 国際誌

Minamiguchi Hitoshi, Fujita Hiroyuki, Atsuta Yoshiko, Asou Norio, Sakura Toru, Ueda Yasunori, Sawa Masashi, Dobashi Nobuaki, Taniguchi Yasuhiro, Suzuki Rikio, Uchino Yoshihito, Tomita Akihiro, Tamaki Shigehisa, Hagihara Maki, Fujimaki Katsumichi, Yanada Masamitsu, Maeda Yoshinobu, Iwanaga Masako, Usui Noriko, Kobayashi Yukio, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Takeshita Akihiro

ANNALS OF HEMATOLOGY   99 巻 ( 12 ) 頁： 2787 - 2800   2020年12月

Multi-Lineage BCR-ABL Expression in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Is Associated With Improved Prognosis but No Specific Molecular Features 査読有り 国際誌

Nishiwaki Satoshi, Kim Jeong Hui, Ito Masafumi, Maeda Matsuyoshi, Okuno Yusuke, Koyama Daisuke, Ozawa Yukiyasu, Gunji Masaharu, Osaki Masahide, Kitamura Kunio, Ushijima Yoko, Ishikawa Yuichi, Miyamura Koichi, Sugiura Isamu, Kiyoi Hitoshi

FRONTIERS IN ONCOLOGY   10 巻   頁： 586567   2020年10月

Phase I study of duvelisib in Japanese patients with relapsed or refractory lymphoma 査読有り 国際誌

Izutsu Koji, Kato Koji, Kiyoi Hitoshi, Yamamoto Go, Shimada Kazuyuki, Akashi Koichi

INTERNATIONAL JOURNAL OF HEMATOLOGY   112 巻 ( 4 ) 頁： 504 - 509   2020年10月

Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity 査読有り 国際誌

Sakai Toshiyasu, Terakura Seitaro, Miyao Kotaro, Okuno Shingo, Adachi Yoshitaka, Umemura Koji, Julamanee Jakrawadee, Watanabe Keisuke, Hamana Hiroshi, Kishi Hiroyuki, Leitner Judith, Steinberger Peter, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

MOLECULAR THERAPY-ONCOLYTICS   18 巻   頁： 613 - 622   2020年9月

Real-world management of infection during chemotherapy for acute leukemia in Japan: from the results of a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group 査読有り 国際誌

Kimura Shun-ichi, Fujita Hanako, Handa Hiroshi, Hiramoto Nobuhiro, Hosono Naoko, Minamiguchi Hitoshi, Takahashi Tsutomu, Kato Hideaki, Ono Takaaki, Kanda Yoshinobu, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

INTERNATIONAL JOURNAL OF HEMATOLOGY   112 巻 ( 3 ) 頁： 409 - 417   2020年9月

Clinical utility of target capture-based panel sequencing in hematological malignancies: A multicenter feasibility study 査読有り 国際誌

Yasuda Takahiko, Sanada Masashi, Nishijima Dai, Kanamori Takashi, Iijima Yuka, Hattori Hiroyoshi, Saito Akiko, Miyoshi Hiroaki, Ishikawa Yuichi, Asou Norio, Usuki Kensuke, Hirabayashi Shinsuke, Kato Motohiro, Ri Masaki, Handa Hiroshi, Ishida Tadao, Shibayama Hirohiko, Abe Masahiro, Iriyama Chisako, Karube Kennosuke, Nishikori Momoko, Ohshima Koichi, Kataoka Keisuke, Yoshida Kenichi, Shiraishi Yuichi, Goto Hiroaki, Adachi Souichi, Kobayashi Ryoji, Kiyoi Hitoshi, Miyazaki Yasushi, Ogawa Seishi, Kurahashi Hiroki, Yokoyama Hisayuki, Manabe Atsushi, Iida Shinsuke, Tomita Akihiro, Horibe Keizo

CANCER SCIENCE   111 巻 ( 9 ) 頁： 3367 - 3378   2020年9月

Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia (vol 111, pg 1314, 2020) 査読有り 国際共著 国際誌

Kiyoi Hitoshi, Morris Joan D., Oh Iekuni, Maeda Yoshinobu, Minami Hironobu, Miyamoto Toshihiro, Sakura Toru, Iida Hiroatsu, Tuglus Catherine A., Chen Yuqi, Dos Santos Cedric, Kalabus James, Anderson Abraham, Hata Tomoko, Nakashima Yasuhiro, Kobayashi Yukio

CANCER SCIENCE   111 巻 ( 8 ) 頁： 3082 - 3082   2020年8月

Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells 査読有り 国際誌

Tange Naoyuki, Hayakawa Fumihiko, Yasuda Takahiko, Odaira Koya, Yamamoto Hideyuki, Hirano Daiki, Sakai Toshiyasu, Terakura Seitaro, Tsuzuki Shinobu, Kiyoi Hitoshi

BIOMEDICINE & PHARMACOTHERAPY   128 巻   頁： 110330   2020年8月

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. 査読有り 国際誌

Tsuzuki S, Yasuda T, Kojima S, Kawazu M, Akahane K, Inukai T, Imaizumi M, Morishita T, Miyamura K, Ueno T, Karnan S, Ota A, Hyodo T, Konishi H, Sanada M, Nagai H, Horibe K, Tomita A, Suzuki K, Muramatsu H, Takahashi Y, Miyazaki Y, Matsumura I, Kiyoi H, Hosokawa Y, Mano H, Hayakawa F

Blood cancer discovery   1 巻 ( 1 ) 頁： 82 - 95   2020年7月

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia 査読有り 国際誌

Tsuzuki Shinobu, Yasuda Takahiko, Kojima Shinya, Kawazu Masahito, Akahane Koshi, Inukai Takeshi, Imaizumi Masue, Morishita Takanobu, Miyamura Koichi, Ueno Toshihide, Karnan Sivasundaram, Ota Akinobu, Hyodo Toshinori, Konishi Hiroyuki, Sanada Masashi, Nagai Hirokazu, Horibe Keizo, Tomita Akihiro, Suzuki Kyogo, Muramatsu Hideki, Takahashi Yoshiyuki, Miyazaki Yasushi, Matsumura Itaru, Kiyoi Hitoshi, Hosokawa Yoshitaka, Mano Hiroyuki, Hayakawa Fumihiko

BLOOD CANCER DISCOVERY   1 巻 ( 1 ) 頁： 82 - 95   2020年7月

Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies 査読有り 国際誌

Mizuno Kazuyuki, Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Kawashima Hiroki, Inukai Yosuke, Toyoda Hidenori, Yokota Kenji, Hase Tetsunari, Maeda Osamu, Kiyoi Hitoshi, Nagino Masato, Hibi Hideharu, Kodera Yasuhiro, Fujimoto Yasushi, Sone Michihiko, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Fujishiro Mitsuhiro

JOURNAL OF GASTROENTEROLOGY   55 巻 ( 6 ) 頁： 653 - 661   2020年6月

Impact of CD56 Continuously Recognizable as Prognostic Value of Acute Promyelocytic Leukemia: Results of Multivariate Analyses in the Japan Adult Leukemia Study Group (JALSG)-APL204 Study and a Review of the Literature 査読有り 国際誌

Takeshita Akihiro, Asou Norio, Atsuta Yoshiko, Furumaki Hiroaki, Sakura Toru, Ueda Yasunori, Sawa Masashi, Dobashi Nobuaki, Taniguchi Yasuhiro, Suzuki Rikio, Nakagawa Masaru, Tamaki Shigehisa, Hagihara Maki, Fujimaki Katsumichi, Minamiguchi Hitoshi, Fujita Hiroyuki, Yanada Masamitsu, Maeda Yoshinobu, Usui Noriko, Kobayashi Yukio, Kiyoi Hitoshi, Ohtake Shigeki, Matsumura Itaru, Naoe Tomoki, Miyazaki Yasushi

CANCERS   12 巻 ( 6 )   2020年6月

JSH Practical Guidelines for Hematological Malignancies, 2018: I. Leukemia-1. Acute myeloid leukemia (AML) 招待有り 査読有り 国際誌

Kiyoi Hitoshi, Yamaguchi Hiroki, Maeda Yoshinobu, Yamauchi Takahiro

INTERNATIONAL JOURNAL OF HEMATOLOGY   111 巻 ( 5 ) 頁： 595 - 613   2020年5月

Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial 査読有り 国際誌

Shimada Kazuyuki, Yamaguchi Motoko, Atsuta Yoshiko, Matsue Kosei, Sato Keijiro, Kusumoto Shigeru, Nagai Hirokazu, Takizawa Jun, Fukuhara Noriko, Nagafuji Koji, Miyazaki Kana, Ohtsuka Eiichi, Okamoto Masataka, Sugita Yasumasa, Uchida Toshiki, Kayukawa Satoshi, Wake Atsushi, Ennishi Daisuke, Kondo Yukio, Izumi Tohru, Kin Yoshihiro, Tsukasaki Kunihiro, Hashimoto Daigo, Yuge Masaaki, Yanagisawa Atsumi, Kuwatsuka Yachiyo, Shimada Satoko, Masaki Yasufumi, Niitsu Nozomi, Kiyoi Hitoshi, Suzuki Ritsuro, Tokunaga Takashi, Nakamura Shigeo, Kinoshita Tomohiro

LANCET ONCOLOGY   21 巻 ( 4 ) 頁： 593 - 602   2020年4月

Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia 査読有り 国際共著 国際誌

Kiyoi Hitoshi, Morris Joan D., Oh Lekuni, Maeda Yoshinobu, Minami Hironobu, Miyamoto Toshihiro, Sakura Toru, Iida Hiroatsu, Tuglus Catherine A., Chen Yuqi, Dos Santos Cedric, Kalabus James, Anderson Abraham, Hata Tomoko, Nakashima Yasuhiro, Kobayashi Yukio

CANCER SCIENCE   111 巻 ( 4 ) 頁： 1314 - 1323   2020年4月

Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy 査読有り 国際誌

Ogawa Mika, Suzuki Nobuaki, Takahashi Nobunori, Tamura Shogo, Suzuki Atsuo, Suzuki Sachiko, Hattori Yuua, Kakihara Misaki, Kanematsu Takeshi, Kojima Toshihisa, Katsumi Akira, Hayakawa Fumihiko, Kojima Tetsuhito, Ishiguro Naoki, Kiyoi Hitoshi, Matsushita Tadashi

THROMBOSIS RESEARCH   188 巻   頁： 103 - 105   2020年4月

Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study 査読有り 国際誌

Okada Norio, Iwama Shintaro, Okuji Takayuki, Kobayashi Tomoko, Yasuda Yoshinori, Wada Eri, Onoue Takeshi, Goto Motomitsu, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Kanda Mitsuro, Yokota Kenji, Hashimoto Naozumi, Ando Masahiko, Fujimoto Yasushi, Nagino Masato, Kodera Yasuhiro, Fujishiro Mitsuhiro, Hibi Hideharu, Sone Michihiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

BRITISH JOURNAL OF CANCER   122 巻 ( 6 ) 頁： 771 - 777   2020年3月

悪性リンパ腫診療の進歩とピットフォール 招待有り

島田和之、清井仁

日本内科学会雑誌   109 巻 ( 3 ) 頁： 574 - 578   2020年3月

<i>FLT3</i> mutations in acute myeloid leukemia: Therapeutic paradigm beyond inhibitor development 招待有り 査読有り 国際誌

Kiyoi, H; Kawashima, N; Ishikawa, Y

CANCER SCIENCE   111 巻 ( 2 ) 頁： 312 - 322   2020年2月

Prospective evaluation of prognostic impact of KIT mutations on acute myeloid leukemia with RUNX1-RUNX1T1 and CBFB-MYH11 査読有り 国際誌

Ishikawa Yuichi, Kawashima Naomi, Atsuta Yoshiko, Sugiura Isamu, Sawa Masashi, Dobashi Nobuaki, Yokoyama Hisayuki, Doki Noriko, Tomita Akihiro, Kiguchi Toru, Koh Shiro, Kanamori Heiwa, Iriyama Noriyoshi, Kohno Akio, Moriuchi Yukiyoshi, Asada Noboru, Hirano Daiki, Togitani Kazuto, Sakura Toru, Hagihara Maki, Tomikawa Tatsuki, Yokoyama Yasuhisa, Asou Norio, Ohtake Shigeki, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Kiyoi Hitoshi

BLOOD ADVANCES   4 巻 ( 1 ) 頁： 66 - 75   2020年1月

Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation 査読有り 国際誌

Kamoshita Sonoko, Murata Makoto, Koyama Daisuke, Julamanee Jakrawadee, Okuno Shingo, Takagi Erina, Miyao Kotaro, Goto Tatsunori, Ozawa Yukiyasu, Miyamura Koichi, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   111 巻 ( 1 ) 頁： 112 - 119   2020年1月

Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia 査読有り 国際誌

Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

INTERNAL MEDICINE   59 巻 ( 5 ) 頁： 683 - 687   2020年

Allogeneic Hematopoietic Stem Cell Transplantation for Post-essential Thrombocythemia and Post-polycythemia Vera Myelofibrosis 査読有り 国際誌

Murata, M; Suzuki, R; Nishida, T; Shirane, S; Shimazu, Y; Minami, Y; Mori, T; Doki, N; Kanda, Y; Uchida, N; Tanaka, M; Ishikawa, J; Togitani, K; Fukuda, T; Ichinohe, T; Atsuta, Y; Nagamura-Inoue, T; Kiyoi, H

INTERNAL MEDICINE   59 巻 ( 16 ) 頁： 1947 - 1956   2020年

Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors.

Okamoto S, Suzuki N, Suzuki A, Suzuki S, Tamura S, Suzuki M, Takahashi N, Kojima T, Kanematsu T, Kojima T, Kiyoi H, Ishiguro N, Matsushita T

TH open : companion journal to thrombosis and haemostasis   3 巻 ( 4 ) 頁： e364-e366   2019年10月

ZNF384-fusion proteins have high affinity for the transcriptional coactivator EP300 and aberrant transcriptional activities 査読有り 国際誌

Yamamoto Hideyuki, Hayakawa Fumihiko, Yasuda Takahiko, Odaira Koya, Minamikawa Yuka, Tange Naoyuki, Hirano Daiki, Kojima Yuki, Morishita Takanobu, Tsuzuki Shinobu, Naoe Tomoki, Kiyoi Hitoshi

FEBS LETTERS   593 巻 ( 16 ) 頁： 2151 - 2161   2019年8月

Exome analysis of treatment-related AML after APL suggests secondary evolution 査読有り 国際共著 国際誌

Wang Tianjiao, Jacoby Meagan A., Duncavage Eric J., Miller Christopher A., Heath Sharon, Rahme Ramy, Fenaux Pierre, Ades Lionel, Renneville Aline, Cassinat Bruno, Takeshita Akihiro, Asou Norio, Miyazaki Yasushi, Kiyoi Hitoshi, Ravandi Farhad, Westervelt Peter, Wartman Lukas D., Welch John S.

BRITISH JOURNAL OF HAEMATOLOGY   185 巻 ( 5 ) 頁： 984 - 987   2019年6月

Efficacy and safety of tyrosine kinase inhibitors for newly diagnosed chronic-phase chronic myeloid leukemia over a 5-year period: results from the Japanese registry obtained by the New TARGET system 招待有り 査読有り 国際誌

Kizaki Masahiro, Takahashi Naoto, Iriyama Noriyoshi, Okamoto Shinichiro, Ono Takaaki, Usui Noriko, Inokuchi Koiti, Nakaseko Chiaki, Kurokawa Mineo, Sumi Masahiko, Nakamura Fumihiko, Kawaguchi Tatsuya, Suzuki Ritsuro, Yamamoto Kazuhito, Ohnishi Kazunori, Matsumura Itaru, Naoe Tomoki, Kizaki M., Mori S., Nemoto T., Sagawa M., Tabayashi T., Tokuhira M., Tomikawa T., Watanabe R., Hatta Y., Inoue Y., Iriyama N., Kobayashi S., Kobayashi Y., Kurita D., Karigane D., Kasahara H., Koda Y., Miyakawa Y., Murakami K., Okamoto S., Watanuki S., Ono T., Nagata Y., Takeshita A., Takahashi N., Kameoka Y., Yoshioka T., Takahashi S., Usui N., Dan K., Inokuchi K., Nakamura K., Abe D., Nakaseko C., Ohwada C., Sakaida E., Shimizu N., Takeuchi M., Arai S., Kogure Y., Koya A., Masamoto Y., Masuda A., Nakazaki K., Toyama K., Hiroshima Y., Ichikawa N., Kirihara T., Kobayashi H., Shimizu I., Sumi M., Ueki T., Hagiwara S., Hirai R., Miwa T., Nakamura F., Nakamura M., Takeshita M., Tanimura A., Hayakawa F., Ishikawa Y., Kiyoi H., Murata M., Tomita A., Kurokawa T., Sugimori C., Arai A., Miura O., Yamamoto M., Imai K., Kobayashi N., Minauchi K., Obara M., Ota S., Ikezoe T., Mori M., Sakai M., Taniguchi A., Togitani K., Hayakawa H., Kajiguchi T., Kamoshita S., Otsuka E., Nishida A., Saburi M., Saburi Y., Iida H., Kato C., Kojima Y., Ohashi H., Miyata Y., Sugimoto K., Yamamoto H., Yokozawa T., Kamae T., Kuyama J., Mitsui H., Morikawa Y., Uchida Y., Ashida T., Hirase C., Kawanishi K., Matsumura I., Miyatake J., Morita Y., Sano T., Shimada T., Tanaka H., Taniguchi Y., Tatsumi Y., Yamaguchi K., Ishida F., Momose K., Nakazawa H., Nishina S., Sakai H., Sekiguchi N., Ito Y., Ohyashiki K., Tauchi T., Hata T., Imaizumi Y., Imanishi D., Itonaga H., Makiyama J., Sawayama Y., Taguchi J., Taguchi M., Taniguchi H., Eguchi G., Matsuda M., Yamairi N., Fukushima N., Ozeki K., Kohno A., Sakura T., Takada S., Kobayashi T., Sakamaki H., Asou N., Kawaguchi T., Kiguchi T., Masunari T., Sezaki N., Iino M., Morinaga K., Ikeda K., Ogawa K., Noji H., Iwasaki H., Takenaka K., Miyamoto T., Handa H., Murakami H., Tsukamoto N., Eto T., Henzan H., Kamitsuji Y., Uoshima N., Hagihara M., Takahashi H., Emi N., Okamoto M., Kawakami K., Waki M., Fukuhara N., Harigae H., Murayama T., Mizuno I., Okumura H., Tsutsumi Y., Usuki K., Fujisaki T., Maeda Y., Suehiro Y., Suzushima H., Yamamoto K., Kanakura Y., Nagasaki K., Muto H., Fujisawa S., Mugitani A., Yamasaki S., Adachi Y., Kamimura T., Takamatsu Y., Ryu T., Chiba S., Ohishi K., Suzuki K., Ogawa D., Mihara H., Fujita H., Kubo K., Yokota A., Yoshida C., Nakachi S., Myojyo T., Kitabayashi A., Suzumiya J., Hino M., Wakita A., Shibata T., Takahashi T., Takamatsu H., Fujimaki K., Tajika K., Mita M., Terui Y., Ito M., Yamane T., Yamamoto K., Yamauchi T., Kohara Y., Takebayashi C., Inagaki A., Tsuji M., Shinzaki H., Moriuchi Y., Ishikawa M., Miyazaki K., Shima E., Kinugawa N.

INTERNATIONAL JOURNAL OF HEMATOLOGY   109 巻 ( 4 ) 頁： 426 - 439   2019年4月

Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity 査読有り 国際誌

Hirano Daiki, Hayakawa Fumihiko, Yasuda Takahiko, Tange Naoyuki, Yamamoto Hideyuki, Kojima Yuki, Morishita Takanobu, Imoto Naoto, Tsuzuki Shinobu, Mano Hiroyuki, Naoe Tomoki, Kiyoi Hitoshi

ONCOGENE   38 巻 ( 13 ) 頁： 2263 - 2274   2019年3月

Defective Epstein-Barr virus in chronic active infection and haematological malignancy 査読有り 国際誌

Okuno Yusuke, Murata Takayuki, Sato Yoshitaka, Muramatsu Hideki, Ito Yoshinori, Watanabe Takahiro, Okuno Tatsuya, Murakami Norihiro, Yoshida Kenichi, Sawada Akihisa, Inoue Masami, Kawa Keisei, Seto Masao, Ohshima Koichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Narita Yohei, Yoshida Masahiro, Goshima Fumi, Kawada Jun-Ichi, Nishida Tetsuya, Kiyoi Hitoshi, Kato Seiichi, Nakamura Shigeo, Morishima Satoko, Yoshikawa Tetsushi, Fujiwara Shigeyoshi, Shimizu Norio, Isobe Yasushi, Noguchi Masaaki, Kikuta Atsushi, Iwatsuki Keiji, Takahashi Yoshiyuki, Kojima Seiji, Ogawa Seishi, Kimura Hiroshi

NATURE MICROBIOLOGY   4 巻 ( 3 ) 頁： 404 - 413   2019年3月

Quantitative Assessment of T Cell Clonotypes in Human Acute Graft-versus-Host Disease Tissues 査読有り 国際誌

Koyama Daisuke, Murata Makoto, Hanajiri Ryo, Akashi Tomohiro, Okuno Shingo, Kamoshita Sonoko, Julamanee Jakrawadee, Takagi Erina, Miyao Kotaro, Sakemura Reona, Goto Tatsunori, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   25 巻 ( 3 ) 頁： 417 - 423   2019年3月

Publisher Correction: Defective Epstein-Barr virus in chronic active infection and haematological malignancy. 査読有り 国際誌

Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H

Nature microbiology   4 巻 ( 3 ) 頁： 544   2019年3月

Tamibarotene maintenance improved relapse-free survival of acute promyelocytic leukemia: a final result of prospective, randomized, JALSG-APL204 study 査読有り 国際誌

Takeshita Akihiro, Asou Norio, Atsuta Yoshiko, Sakura Toru, Ueda Yasunori, Sawa Masashi, Dobashi Nobuaki, Taniguchi Yasuhiro, Suzuki Rikio, Nakagawa Masaru, Tamaki Shigehisa, Hagihara Maki, Fujimaki Katsumichi, Furumaki Hiroaki, Obata Yukako, Fujita Hiroyuki, Yanada Masamitsu, Maeda Yoshinobu, Usui Noriko, Kobayashi Yukio, Kiyoi Hitoshi, Ohtake Shigeki, Matsumura Itaru, Naoe Tomoki, Miyazaki Yasushi

LEUKEMIA   33 巻 ( 2 ) 頁： 358 - 370   2019年2月

Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study 査読有り 国際誌

Kawashima Naomi, Akashi Akimi, Nagata Yasunobu, Kihara Rika, Ishikawa Yuichi, Asou Norio, Ohtake Shigeki, Miyawaki Shuichi, Sakura Toru, Ozawa Yukiyasu, Usui Noriko, Kanamori Heiwa, Ito Yoshikazu, Imai Kiyotoshi, Suehiro Youko, Kitamura Kunio, Sakaida Emiko, Takeshita Akihiro, Suzushima Hitoshi, Naoe Tomoki, Matsumura Itaru, Miyazaki Yasushi, Ogawa Seishi, Kiyoi Hitoshi

ANNALS OF HEMATOLOGY   98 巻 ( 1 ) 頁： 83 - 91   2019年1月

[Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient]. 査読有り

Harada Y, Murata M, Matsumoto A, Kato D, Yagi T, Yaguchi T, Yoshikawa T, Takeichi T, Akiyama M, Yamaguchi Y, Koyama D, Terakura S, Nishida T, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology   60 巻 ( 12 ) 頁： 1641 - 1646   2019年

[Acute myeloid leukemia: AML]. 招待有り

Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology   60 巻 ( 3 ) 頁： 224 - 225   2019年

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. 査読有り

Proceedings of the National Academy of Sciences of the United States of America     2018年11月

Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells. 査読有り

Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H

Cancer science     2018年11月

Final analysis of the JALSG Ph+ALL202 study: tyrosine kinase inhibitor-combined chemotherapy for Ph plus ALL 査読有り 国際誌

Hatta Yoshihiro, Mizuta Shuichi, Matsuo Keitaro, Ohtake Shigeki, Iwanaga Masako, Sugiura Isamu, Doki Noriko, Kanamori Heiwa, Ueda Yasunori, Yoshida Chikamasa, Dobashi Nobuaki, Maeda Tomoya, Yujiri Toshiaki, Monma Fumihiko, Ito Yoshikazu, Hayakawa Fumihiko, Takeuchi Jin, Kiyoi Hitoshi, Miyazaki Yasushi, Naoe Tomoki

ANNALS OF HEMATOLOGY   97 巻 ( 9 ) 頁： 1535 - 1545   2018年9月

Prognostic Analysis According to the 2017 ELN Risk Stratification by Genetics in Adult Acute Myeloid Leukemia Patients Treated in The Japan Adult Leukemia Study Group (JALSG) AML201 study 査読有り

Harada Yasuhiko, Nagata Yasunobu, Kihara Rika, Ishikawa Yuichi, Asou Norio, Ohtake Shigeki, Miyawaki Shuichi, Sakura Toru, Ozawa Yukiyasu, Usui Noriko, Kanamori Heiwa, Ito Yoshikazu, Imai Kiyotoshi, Suehiro Youko, Kobayashi Shinichi, Kitamura Kunio, Sakaida Emiko, Onizuka Makoto, Takeshita Akihiro, Ishida Fumihiro, Suzushima Hitoshi, Ishizawa Kenichi, Naoe Tomoki, Matsumura Itaru, Miyazaki Yasushi, Ogawa Seishi, Kiyoi Hitoshi

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   18 巻   頁： S196-S196   2018年9月

Impact of hospital length of stay on the risk of readmission and overall survival after allogeneic stem cell transplantation 査読有り 国際誌

Seto Aika, Atsuta Yoshiko, Kawashima Naomi, Ozawa Yukiyasu, Miyamura Koichi, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   108 巻 ( 3 ) 頁： 290 - 297   2018年9月

Biology and management of primary effusion lymphoma. 査読有り

Shimada K, Hayakawa F, Kiyoi H

Blood     2018年8月

Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response 査読有り 国際誌

Ueda Norihiro, Uemura Yasushi, Zhang Rong, Kitayama Shuichi, Iriguchi Shoichi, Kawai Yohei, Yasui Yutaka, Tatsumi Minako, Ueda Tatsuki, Liu Tian-Yi, Mizoro Yasutaka, Okada Chihiro, Watanabe Akira, Nakanishi Mahito, Senju Satoru, Nishimura Yasuharu, Kuzushima Kiyotaka, Kiyoi Hitoshi, Naoe Tomoki, Kaneko Shin

STEM CELL REPORTS   10 巻 ( 6 ) 頁： 1935 - 1946   2018年6月

Infectious complications in adults undergoing intensive chemotherapy for acute myeloid leukemia in 2001-2005 using the Japan Adult Leukemia Study Group AML201 protocols.

Kato H, Fujita H, Akiyama N, Kimura SI, Hiramoto N, Hosono N, Takahashi T, Shigeno K, Minamiguchi H, Miyatake J, Handa H, Kanda Y, Yoshida M, Miyawaki S, Ohtake S, Naoe T, Kiyoi H, Matsumura I, Miyazaki Y, Japan Adult Leukemia Study Group.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     2018年6月

Introduction of Genetically Modified CD3 zeta Improves Proliferation and Persistence of Antigen-Specific CTLs 査読有り 国際誌

Miyao Kotaro, Terakura Seitaro, Okuno Shingo, Julamanee Jakrawadee, Watanabe Keisuke, Hamana Hiroshi, Kishi Hiroyuki, Sakemura Reona, Koyama Daisuke, Goto Tatsunori, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

CANCER IMMUNOLOGY RESEARCH   6 巻 ( 6 ) 頁： 733 - 744   2018年6月

Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia. 査読有り

Tanaka Y, Kawazu M, Yasuda T, Tamura M, Hayakawa F, Kojima S, Ueno T, Kiyoi H, Naoe T, Mano H

Haematologica     2018年5月

Mutation analysis of therapy-related myeloid neoplasms 査読有り 国際誌

Nishiyama Takahiro, Ishikawa Yuichi, Kawashima Naomi, Akashi Akimi, Adachi Yoshiya, Hattori Hikaru, Ushijima Yoko, Kiyoi Hitoshi

CANCER GENETICS   222 巻   頁： 38 - 45   2018年4月

Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol 査読有り 国際誌

Goto Tatsunori, Murata Makoto, Terakura Seitaro, Nishida Tetsuya, Adachi Yoshiya, Ushijima Yoko, Shimada Kazuyuki, Ishikawa Yuichi, Hayakawa Fumihiko, Nishio Nobuhiro, Nishiwaki Satoshi, Hirakawa Akihiro, Kato Katsuyoshi, Takahashi Yoshiyuki, Kiyoi Hitoshi

MEDICINE   97 巻 ( 17 ) 頁： e0449   2018年4月

Analysis of the oligomeric states of nucleophosmin using size exclusion chromatography 査読有り 国際誌

Sakashita Gyosuke, Kiyoi Hitoshi, Naoe Tomoki, Urano Takeshi

SCIENTIFIC REPORTS   8 巻 ( 1 ) 頁： 4008   2018年3月

Clinical impact of underweight status at diagnosis on elderly patients with acute myeloid leukemia: a retrospective study of JALSG GML200. 査読有り

Harada K, Doki N, Miyazaki Y, Wakita A, Ohtake S, Takada S, Komatsu H, Kubo K, Takeshita A, Adachi Y, Kiyoi H, Yamaguchi T, Yoshida M, Naoe T, Ohashi K

Annals of hematology     2018年3月

High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG 査読有り 国際誌

Sakura T., Hayakawa F., Sugiura I., Murayama T., Imai K., Usui N., Fujisawa S., Yamauchi T., Yujiri T., Kakihana K., Ito Y., Kanamori H., Ueda Y., Miyata Y., Kurokawa M., Asou N., Ohnishi K., Ohtake S., Kobayashi Y., Matsuo K., Kiyoi H., Miyazaki Y., Naoe T.

LEUKEMIA   32 巻 ( 3 ) 頁： 626 - 632   2018年3月

Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study. 査読有り

Harada Y, Nagata Y, Kihara R, Ishikawa Y, Asou N, Ohtake S, Miyawaki S, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Onizuka M, Takeshita A, Ishida F, Suzushima H, Ishizawa K, Naoe T, Matsumura I, Miyazaki Y, Ogawa S, Kiyoi H, Japan Adult Leukemia Study Group JALSG.

Leukemia research   66 巻   頁： 20-27   2018年3月

High Incidence of Extensive Chronic Gvhd in Patients with the REG3A Rs7588571 Non-GG Genotype 査読有り

Murata Makoto, Koyama Daisuke, Hanajiri Ryo, Okuno Shingo, Kamoshita Sonoko, Julamanee Jakrawadee, Takagi Erina, Hirano Daiki, Miyao Kotaro, Sakemura Reona, Goto Tatsunori, Hayakawa Fumihiko, Seto Aika, Ozawa Yukiyasu, Miyamura Koichi, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   24 巻 ( 3 ) 頁： S192-S193   2018年3月

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study 査読有り 国際誌

Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

JOURNAL OF THE ENDOCRINE SOCIETY   2 巻 ( 3 ) 頁： 241 - 251   2018年3月

Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia. 査読有り

Kamijo R, Itonaga H, Kihara R, Nagata Y, Hata T, Asou N, Ohtake S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Naoe T, Kiyoi H, Miyazaki Y

Leukemia research   65 巻   頁： 34-41   2018年2月

Intrabone single unit cord blood transplantation for hematological malignancies 査読有り

Murata Makoto, Maeda Yoshinobu, Masuko Masayoshi, Fukuhara Noriko, Nishida Tetsuya, Terakura Seitaro, Ishikawa Yuichi, Tanimoto Mitsune, Shibasaki Yasuhiko, Suzuki Ritsuro, Kodera Yoshihisa, Kiyoi Hitoshi, Naoe Tomoki

CANCER SCIENCE   109 巻   頁： 757-757   2018年1月

BCR-ABL-specific CD4(+) T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells 査読有り 国際誌

Ueda Norihiro, Zhang Rong, Tatsumi Minako, Liu Tian-Yi, Kitayama Shuichi, Yasui Yutaka, Sugai Shiori, Iwama Tatsuaki, Senju Satoru, Okada Seiji, Nakatsura Tetsuya, Kuzushima Kiyotaka, Kiyoi Hitoshi, Naoe Tomoki, Kaneko Shin, Uemura Yasushi

CELLULAR & MOLECULAR IMMUNOLOGY   15 巻 ( 1 ) 頁： 15 - 26   2018年1月

Underweight status at diagnosis is associated with poorer outcomes in adult patients with acute myeloid leukemia: a retrospective study of JALSG AML 201 査読有り 国際誌

Harada Kaito, Doki Noriko, Hagino Takeshi, Miyawaki Shuichi, Ohtake Shigeki, Kiyoi Hitoshi, Miyazaki Yasushi, Fujita Hiroyuki, Usui Noriko, Okumura Hirokazu, Miyamura Koichi, Nakaseko Chiaki, Fujieda Atsushi, Nagai Tadashi, Yamane Takahisa, Sakamaki Hisashi, Ohnishi Kazunori, Naoe Tomoki, Ohno Ryuzo, Ohashi Kazuteru

ANNALS OF HEMATOLOGY   97 巻 ( 1 ) 頁： 73 - 81   2018年1月

Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia. 査読有り

Hattori H, Ishikawa Y, Kawashima N, Akashi A, Yamaguchi Y, Harada Y, Hirano D, Adachi Y, Miyao K, Ushijima Y, Terakura S, Nishida T, Matsushita T, Kiyoi H

PloS one   13 巻 ( 10 ) 頁： e0204850   2018年

Underweight status at diagnosis is associated with poorer outcomes in adult patients with acute myeloid leukemia: a retrospective study of JALSG AML 201. 査読有り

Harada K, Doki N, Hagino T, Miyawaki S, Ohtake S, Kiyoi H, Miyazaki Y, Fujita H, Usui N, Okumura H, Miyamura K, Nakaseko C, Fujieda A, Nagai T, Yamane T, Sakamaki H, Ohnishi K, Naoe T, Ohno R, Ohashi K

Ann Hematol.     2017年12月

Efficacy and safety of autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia: A study protocol for a multicenter exploratory prospective study (Auto-Ph17 study) 査読有り 国際誌

Nishiwaki Satoshi, Sugiura Isamu, Miyata Yasuhiko, Saito Shigeki, Sawa Masashi, Nishida Tetsuya, Miyamura Koichi, Kuwatsuka Yachiyo, Kohno Akio, Yuge Masaaki, Kasai Masanobu, Iida Hiroatsu, Kurahashi Shingo, Osaki Masahide, Goto Tatsunori, Terakura Seitaro, Murata Makoto, Nishikawa Hiroyoshi, Kiyoi Hitoshi

MEDICINE   96 巻 ( 52 ) 頁： e9568   2017年12月

Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome. 査読有り

Shirahata-Adachi M, Iriyama C, Tomita A, Suzuki Y, Shimada K, Kiyoi H.

Leuk Res   63 巻   頁： 90-97   2017年11月

Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia. 査読有り

Kuwatsuka Y, Tomizawa D, Kihara R, Nagata Y, Shiba N, Iijima-Yamashita Y, Shimada A, Deguchi T, Miyachi H, Tawa A, Taga T, Kinoshita A, Nakayama H, Kiyokawa N, Saito AM, Koh K, Goto H, Kosaka Y, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Ogawa S, Naoe T, Hayashi Y, Horibe K, Manabe A, Mizutani S, Adachi S, Kiyoi H.

Int J Hematol     2017年10月

Identification of volasertib-resistant mechanism and evaluation of combination effects with volasertib and other agents on acute myeloid leukemia. 査読有り

Adachi Y, Ishikawa Y, Kiyoi H.

Oncotarget   8 巻   頁： 78452-78465   2017年10月

A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study). 査読有り

Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Hanaoka N, Nakakuma H, Hasegawa D, Manabe A, Fujishima N, Fujii N, Tanimoto M, Morita Y, Matsuda A, Fujieda A, Katayama N, Ohashi H, Nagai H, Terada Y, Hino M, Sato K, Obara N, Chiba S, Usuki K, Ohta M, Imataki O, Uemura M, Takaku T, Komatsu N, Kitanaka A, Shimoda K, Watanabe K, Tohyama K, Takaori-Kondo A, Harigae H, Arai S, Miyazaki Y, Ozawa K, Kurokawa M; for National Research Group on Idiopathic Bone Marrow Failure Syndromes.

Am J Hematol   92 巻   頁： 1324-1332   2017年9月

High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype.

Koyama D, Murata M, Hanajiri R, Okuno S, Kamoshita S, Julamanee J, Takagi E, Hirano D, Miyao K, Sakemura R, Goto T, Hayakawa F, Seto A, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H.

PLoS One12     頁： e0185213   2017年9月

Deeper molecular response is a predictive factor for treatment-free remission after imatinib discontinuation in patients with chronic phase chronic myeloid leukemia: the JALSG-STIM213 study. 査読有り

Takahashi N, Tauchi T, Kitamura K, Miyamura K, Saburi Y, Hatta Y, Miyata Y, Kobayashi S, Usuki K, Matsumura I, Minami Y, Usui N, Fukuda T, Takada S, Ishikawa M, Fujimaki K, Gomyo H, Sasaki O, Ohishi K, Miyake T, Imai K, Suzushima H, Mitsui H, Togitani K, Kiguchi T, Atsuta Y, Ohtake S, Ohnishi K, Kobayashi Y, Kiyoi H, Miyazaki Y, Naoe T; Japan Adult Leukemia Study Group.

Int J Hematol     2017年9月

Clinical effectiveness of geriatric assessment for predicting the tolerability of outpatient chemotherapy in older adults with cancer. 査読有り

Hayashi N, Matsuoka A, Goto H, Gotoh M, Kiyoi H, Kodera Y, Nagino M, Nagashima F, Ando Y.

J Geriatr Oncol     2017年8月

Phase II study of intrabone single unit cord blood transplantation for hematological malignancies. 査読有り

Murata M, Maeda Y, Masuko M, Onishi Y, Endo T, Terakura S, Ishikawa Y, Iriyama C, Ushijima Y, Goto T, Fujii N, Tanimoto M, Kobayashi H, Shibasaki Y, Fukuhara N, Inamoto Y, Suzuki R, Kodera Y, Matsushita T, Kiyoi H, Naoe T, Nishida T.

Cancer Sci   108 巻   頁： 1634-1639   2017年6月

MOLECULAR MARKERS PREDICTING RESPONSE TO AZACITIDINE TREATMENT FOR MYELODYSPLASTIC SYNDROMES

Nannya Y., Takeda J., Shiozawa Y., Shiraishi Y., Okuno Y., Kataoka K., Chiba K., Tanaka H., Sanada M., Chiba S., Asou N., Kiyoi H., Imai K., Hirase C., Dobashi N., Kiguchi T., Nakao S., Ohyashiki K., Miyazaki Y., Naoe T., Makishima H., Miyano S., Yoshida K., Ogawa S.

HAEMATOLOGICA   102 巻   頁： 98-99   2017年6月

Management of infection during chemotherapy for acute leukemia in Japan: a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group. 査読有り

Kimura SI, Fujita H, Kato H, Hiramoto N, Hosono N, Takahashi T, Shigeno K, Hatsumi N, Minamiguchi H, Miyatake J, Handa H, Akiyama N, Kanda Y, Yoshida M, Kiyoi H, Miyazaki Y, Naoe T; Japan Adult Leukemia Study Group (JALSG).

Support Care Cancer   25 巻   頁： 3515-3521   2017年6月

[I.Genetic Abnormalities Associated with Acute Leukemia and a Development of Molecular Therapies].

Adachi Y, Kiyoi H

Gan to kagaku ryoho. Cancer & chemotherapy   44 巻 ( 5 ) 頁： 380-385   2017年5月

YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma. 査読有り

Kojima Y, Hayakawa F, Morishita T, Sugimoto K, Minamikawa Y, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H.

Pharmacol Res   120 巻   頁： 242-251   2017年4月

Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia 査読有り 国際誌

Togasaki E., Takeda J., Yoshida K., Shiozawa Y., Takeuchi M., Oshima M., Saraya A., Iwama A., Yokote K., Sakaida E., Hirase C., Takeshita A., Imai K., Okumura H., Morishita Y., Usui N., Takahashi N., Fujisawa S., Shiraishi Y., Chiba K., Tanaka H., Kiyoi H., Ohnishi K., Ohtake S., Asou N., Kobayashi Y., Miyazaki Y., Miyano S., Ogawa S., Matsumura I., Nakaseko C., Naoe T.

BLOOD CANCER JOURNAL   7 巻 ( 4 ) 頁： e559   2017年4月

Impact of T-cell chimerism on relapse after cord blood transplantation for hematological malignancies: Nagoya Blood and Marrow Transplantation Group study 査読有り 国際誌

Yokohata E., Kuwatsuka Y., Ohashi H., Terakura S., Kawashima N., Seto A., Kurahashi S., Ozawa Y., Goto T., Imahashi N., Nishida T., Miyao K., Sakemura R., Kato T., Sawa M., Kohno A., Sao H., Iida H., Kiyoi H., Naoe T., Miyamura K., Murata M.

BONE MARROW TRANSPLANTATION   52 巻 ( 4 ) 頁： 612 - 614   2017年4月

Retrospective analysis of in vivo recovery and clearance during continuous infusion of recombinant factor VIII products: a single-institution study

Suzuki N., Hirakawa A., Kishimoto M., Kanematsu T., Ogawa M., Kiyoi H., Matsushita T.

HAEMOPHILIA   23 巻 ( 2 ) 頁： 215-221   2017年3月

Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism.

Aoki T, Shimada K, Sakamoto A, Sugimoto K, Morishita T, Kojima Y, Shimada S, Kato S, Iriyama C, Kuno S, Harada Y, Tomita A, Hayakawa F, Kiyoi H.

Oncotarget   8 巻   頁： 13085-13098   2017年2月

[Malignant lymphoma with cardiac involvement]. 査読有り

Terakura S, Onji M, Iriyama C, Goto T, Ushijima Y, Shimada K, Ishikawa Y, Nishida T, Hayakawa F, Murata M, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology   58 巻 ( 3 ) 頁： 239 - 242   2017年

A Tet-On Inducible System for Controlling CD19-Chimeric Antigen Receptor Expression upon Drug Administration. 査読有り

Sakemura R, Terakura S, Watanabe K, Julamanee J, Takagi E, Miyao K, Koyama D, Goto T, Hanajiri R, Nishida T, Murata M, Kiyoi H.

Cancer Immunol Res.   4 巻 ( 8 ) 頁： 658-68   2016年8月

SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. 査読有り

Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A, Kiyoi H.

Cancer Sci.     頁： [Epub ahead of print]   2016年6月

PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation. 査読有り

Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, Naoe T, Kiyoi H.

Biochem Biophys Res Commun.   475 巻 ( 2 ) 頁： 176-81   2016年6月

Peripheral blood cell-free DNA is an alternative tumor DNA source reflecting disease status in myelodysplastic syndromes. 査読有り

Suzuki Y, Tomita A, Nakamura F, Iriyama C, Shirahata-Adachi M, Shimada K, Akashi A, Ishikawa Y, Kaneda N, Kiyoi H.

Cancer Sci.     頁： [Epub ahead of print]   2016年6月

Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells. 査読有り

Chen F, Ishikawa Y, Akashi A, Naoe T, Kiyoi H.

Oncotarget.     頁： [Epub ahead of print]   2016年6月

Live-cell single-molecule imaging of the cytokine receptor MPL for analysis of dynamic dimerization. 査読有り

Sakamoto A, Tsukamoto T, Furutani Y, Sudo Y, Shimada K, Tomita A, Kiyoi H, Kato T, Funatsu T.

J Mol Cell Biol.     頁： [Epub ahead of print]   2016年6月

BCR-ABL-specific CD4+ T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells. 査読有り

Ueda N, Zhang R, Tatsumi M, Liu TY, Kitayama S, Yasui Y, Sugai S, Iwama T, Senju S, Okada S, Nakatsura T, Kuzushima K, Kiyoi H, Naoe T, Kaneko S, Uemura Y.

Cell Mol Immunol     頁： [Epub ahead of print]   2016年5月

Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells. 査読有り

Maeda K, Enomoto A, Hara A, Asai N, Kobayashi T, Horinouchi A, Maruyama S, Ishikawa Y, Nishiyama T, Kiyoi H, Kato T, Ando K, Weng L, Mii S, Asai M, Mizutani Y, Watanabe O, Hirooka Y, Goto H, Takahashi M.

Sci Rep.   6 巻   頁： 22288   2016年2月

B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia. 査読有り

Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.

J Biol Chem.   291 巻 ( 9 ) 頁： 4723-31   2016年2月

The first case of antithrombin-resistant prothrombin Belgrade mutation in Japanese. 査読有り

Kishimoto M, Suzuki N, Murata M, Ogawa M, Kanematsu T, Takagi A, Kiyoi H, Kojima T, Matsushita T.

Ann Hematol.   95 巻 ( 3 ) 頁： 541-2   2016年2月

A case of MYH9 disorders caused by a novel mutation (p.K74E). 査読有り

Kanematsu T, Suzuki N, Yoshida T, Kishimoto M, Aoki T, Ogawa M, Kagami Y, Kiyoi H, Matsushita T, Kunishima S.

Ann Hematol   95 巻 ( 1 ) 頁： 161-3   2016年1月

Clinical usefulness of WT1 mRNA expression in bone marrow detected by a new WT1 mRNA assay kit for monitoring acute myeloid leukemia: a comparison with expression of WT1 mRNA in peripheral blood. 査読有り

Kitamura K, Nishiyama T, Ishiyama K, Miyawaki S, Miyazaki K, Suzuki K, Masaie H, Okada M, Ogawa H, Imai K, Kiyoi H, Naoe T, Yokoyama Y, Chiba S, Hata T, Miyazaki Y, Hatta Y, Takeuchi J, Nannya Y, Kurokawa M, Ueda Y, Koga D, Sugiyama H, Takaku F.

Int J Hematol.   103 巻 ( 1 ) 頁： 53-62   2016年1月

High-dose chemotherapy followed by autologous stem cell transplantation for relapsed/refractory primary mediastinal large B-cell lymphoma. 査読有り

Aoki T, Shimada K, Suzuki R, Izutsu K, Tomita A, Maeda Y, Takizawa J, Mitani K, Igarashi T, Sakai K, Miyazaki K, Mihara K, Ohmachi K, Nakamura N, Takasaki H, Kiyoi H, Nakamura S, Kinoshita T, Ogura M.

Blood Cancer J.   5 巻   頁： e372   2015年12月

Overview: A New Era of Cancer Genome in Myeloid Malignancies. 招待有り 査読有り

Kiyoi H.

Oncology.   89 巻 ( Suppl 1 ) 頁： 1-3   2015年11月

Phase I trial of volasertib, a Polo-like kinase inhibitor, in Japanese patients with acute myeloid leukemia. 査読有り

Kobayashi Y, Yamauchi T, Kiyoi H, Sakura T, Hata T, Ando K, Watabe A, Harada A, Taube T, Miyazaki Y, Naoe T.

Cancer Sci.   106 巻 ( 11 ) 頁： 1590-5   2015年11月

Target Antigen Density Governs the Efficacy of Anti-CD20-CD28-CD3 ζ Chimeric Antigen Receptor-Modified Effector CD8+ T Cells. 査読有り

Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M.

J Immunol.   194 巻   頁： 911-20   2015年

Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells. 査読有り

Sugimoto K, Hayakawa F, Shimada S, Morishita T, Shimada K, Katakai T, Tomita A, Kiyoi H, Naoe T.

Sci Rep.   5 巻   頁： 13054   2015年

Integration of humoral and cellular HLA-specific immune responses in cord blood allograft rejection. 査読有り

Hanajiri R, Murata M, Sugimoto K, Murase M, Sakemura R, Goto T, Watanabe K, Imahashi N, Terakura S, Ohashi H, Akatsuka Y, Kurahashi S, Miyamura K, Kiyoi H, Nishida T, Naoe T.

Bone Marrow Transplant   50 巻   頁： 1187-94   2015年

FLT3 Inhibitors: Recent Advances And Problems For Clinical Application. 招待有り 査読有り

Kiyoi H

Nagoya J Med Sci   77 巻   頁： 7-17   2015年

Chimerism status after unrelated donor bone marrow transplantation with fludarabine-melphalan conditioning is affected by the melphalan dose and is predictive of relapse. 査読有り

Imahashi N, Ohashi H, Terakura S, Miyao K, Sakemura R, Kato T, Sawa M, Yokohata E, Kurahashi S, Ozawa Y, Nishida T, Kiyoi H, Watamoto K, Kohno A, Kasai M, Kato C, Iida H, Naoe T, Miyamura K, Murata M; for the Nagoya Blood and Marrow Transplantation Group.

Ann Hematol   94 巻   頁： 1139-48   2015年

Simple and Efficient Generation of Virus-specific T Cells for Adoptive Therapy Using Anti-4-1BB Antibody. 査読有り

Imahashi N, Nishida T, Goto T, Terakura S, Watanabe K, Hanajiri R, Sakemura R, Imai M, Kiyoi H, Naoe T, Murata M.

J Immunother.   38 巻   頁： 62-70   2015年

Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group. 査読有り

Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T; Japan Adult Leukemia Study Group (JALSG).

Blood Cancer J.   4 巻   頁： e252   2014年10月

De novo diffuse large B-cell lymphoma with a CD20 immunohistochemistry-positive and flow cytometry-negative phenotype: Molecular mechanisms and correlation with rituximab sensitivity. 査読有り

Tokunaga T, Tomita A, Sugimoto K, Shimada K, Iriyama C, Hirose T, Shirahata-Adachi M, Suzuki Y, Mizuno H, Kiyoi H, Asano N, Nakamura S, Kinoshita T, Naoe T.

Cancer Sci   105 巻   頁： 35-43   2014年

Efficacy of ofatumumab against rituximab-resistant B-CLL/SLL cells with low CD20 protein expression. 査読有り

Shimada K, Tomita A, Saito S, Kiyoi H.

Br J Haematol   166 巻   頁： 455-457   2014年

Expression of CD56 is an unfavorable prognostic factor for acute promyelocytic leukemia with higher initial white blood cell counts. 査読有り

Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Emi N, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Kimura Y, Iwanaga M, Asou N, Naoe T; The Japan Adult Leukemia Study Group.

Cancer Sci   105 巻   頁： 97-104   2014年

Gene mutations of acute myeloid leukemia in the genome era. 招待有り 査読有り

Naoe T, Kiyoi H

Int J Hematol   97 巻   頁： 165-174   2013年

The demarcation between younger and older acute myeloid leukemia patients: a pooled analysis of 3 prospective studies. 査読有り

Yanada M, Ohtake S, Miyawaki S, Sakamaki H, Sakura T, Maeda T, Miyamura K, Asou N, Oh I, Miyatake J, Kanbayashi H, Takeuchi J, Takahashi M, Dobashi D, Kiyoi H, Miyazaki Y, Emi N, Kobayashi Y, Ohno R, Naoe T.

Cancer   ( 119 ) 頁： in press   2013年

GATA2 zinc finger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation. 査読有り

Niimi K, Kiyoi H, Ishikawa Y, Hayakawa F, Kurahashi S, Kihara R, Tomita A and Naoe T.

Leukemia Research Reports   2 巻   頁： 21-25   2013年

Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation. 査読有り

Ando K, Tsushima H, Matsuo E, Horio K, Tominaga-Sato S, Imanishi D, Imaizumi Y, Iwanaga M, Itonaga H, Yoshida S, Hata T, Moriuchi R, Kiyoi H, Nimer S, Mano H, Naoe T, Tomonaga M, Miyazaki Y.

J Biol Chem   288 巻   頁： 9457-9467   2013年

Guest editorial: efficacy of and resistance to molecularly targeted therapy for myeloid malignancies. 招待有り 査読有り

Kiyoi H.

Int J Hematol   97 巻   頁： 681-682   2013年

Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97. 査読有り

Fujita H, Asou N, Iwanaga M, Hyo R, Nomura S, Kiyoi H, Okada M, Inaguma Y, Matsuda M, Yamauchi T, Ohtake S, Izumi T, Nakaseko C, Ishigatsubo Y, Shinagawa K, Takeshita A, Miyazaki Y, Ohnishi K, Miyawaki S, Naoe T; Japan Adult Leukemia Study Group.

Cancer Sci   104 巻   頁： 1339-45   2013年

Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in acute promyelocytic leukemia. 招待有り 査読有り

Tomita A, Kiyoi H, Naoe T.

Int J Hematol   97 巻   頁： 717-725   2013年

Molecular lesions in childhood and adult acute megakaryoblastic leukaemia.

Hama A, Muramatsu H, Makishima H, Sugimoto Y, Szpurka H, Jasek M, O'Keefe C, Takahashi Y, Sakaguchi H, Doisaki S, Shimada A, Watanabe N, Kato K, Kiyoi H, Naoe T, Kojima S, Maciejewski JP.

Br J Haematol   156 巻   頁： 316-325   2012年

Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin. 査読有り

Kajiguchi T, Katsumi A, Tanizaki R, Kiyoi H, Naoe T

Eur J Haematol   88 巻   頁： 314-20   2012年

Long-term outcome of imatinib therapy, with assessment of its dosage and blood levels, for chronic myelogenous leukemia. 査読有り

Ohnishi K, Nakaseko C, Takeuchi J, Fujisawa S, Nagai T, Yamazaki H, Tauchi T, Imai K, Mori N, Yagasaki F, Maeda Y, Usui N, Miyazaki Y, Miyamura K, Kiyoi H, Ohtake S, Naoe T.

Cancer Sci   103 巻   頁： 1071-1078   2012年

Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome. 査読有り

Iriyama C, Tomita A, Hoshino H, Shirahata M, Furukawa-Hibi Y, Yamada K, Kiyoi H, Naoe T.

Biochem Biophys Res Commun   419 巻   頁： 662-9   2012年

CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737. 査読有り

Shimada K, Tomita A, Minami Y, Abe A, Hind CK, Kiyoi H, Cragg MS, Naoe T.

Exp Hematol   40 巻   頁： 724-737   2012年

Randomized comparison of fixed-schedule versus response-oriented individualized induction therapy and use of ubenimex during and after consolidation therapy for elderly patients with acute myeloid leukemia: the JALSG GML200 Study. 査読有り

Wakita A, Ohtake S, Takada S, Yagasaki F, Komatsu H, Miyazaki Y, Kubo K, Kimura Y, Takeshita A, Adachi Y, Kiyoi H, Yamaguchi T, Yoshida M, Ohnishi K, Miyawaki S, Naoe T, Ueda R, Ohno R.

Int J Hematol   96 巻   頁： 84-93   2012年

Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia. 査読有り

Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S.

Blood   120 巻   頁： 1485-8   2012年

Long-term outcome and prognostic factors of elderly patients with acute promyelocytic leukemia. 査読有り

Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Kimura Y, Iwanaga M, Asou N, Naoe T.

Cancer Sci   103 巻 ( 11 ) 頁： 1974-1978   2012年

Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: JALSG AML201 Study. 査読有り

Ohtake S, Miyawaki S, Fujita H, Kiyoi H, Shinagawa K, Usui N, Okumura H, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R.

Blood   117 巻 ( 117 ) 頁： 2358-2365   2011年

A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib-resistance: sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis. 査読有り

Sakai K, Ishikawa Y, Mori Y, Kobayashi M, Iriyama C, Ozawa Y, Suzuki T, Minami Y, Ishikawa K, Kaneda N, Naoe T, Kiyoi H.

Int J Hematol   93 巻   頁： 237-242   2011年

Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. 査読有り

Katsumi A, Nishida T, Murata M, Terakura S, Shimada K, Saito S, Kobayashi M, Kodaira A, Shibata S, Oda I, Yagi T, Kiyoi H, Matsushita T, Kojima T, Naoe T.

J Clin Exp Hematop   51 巻   頁： 63-65   2011年

Phase I trial of gemtuzumab ozogamicin in intensive combination chemotherapy for relapsed or refractory adult acute myeloid leukemia (AML): Japan Adult Leukemia Study Group (JALSG)-AML206 study. 査読有り

Usui N, Takeshita A, Nakaseko C, Dobashi N, Fujita H, Kiyoi H, Kobayashi Y, Sakura T, Yahagi Y, Shigeno K, Ohwada C, Miyazaki Y, Ohtake S, Miyawaki S, Naoe T, Ohnishi K

Cancer Sci   102 巻   頁： 1358-1365   2011年

Prevalence and clinical characteristics of N-terminally truncated WT1 expression in acute myeloid leukemia. 査読有り

Ishikawa Y, Kiyoi H, Naoe T.

Leuk Res   35 巻   頁： 685-688   2011年

A randomized comparison of four courses of standard-dose multiagent chemotherapy versus three courses of high-dose cytarabine alone in post-remission therapy for acute myeloid leukemia in adults: the JALSG AML201 study. 査読有り

Miyawaki S, Ohtake S, Fujisawa S, Kiyoi H, Shinagawa K, Usui N, Sakura T, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R.

Blood   117 巻   頁： 2366-2372   2011年

FLT3/ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signaling. 査読有り

Katsumi A, Kiyoi H, Abe A, Tanizaki R, Iwasaki T, Kobayashi M, Matsushita T, Senga T, Kohno T, Kojima T, Kaibuchi K, Hamaguchi M, Naoe T.

Eur J Haematol   86 巻   頁： 191-198   2011年

Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study. 査読有り

Ishikawa Y, Kiyoi H, Watanabe K, Miyamura K, Nakano Y, Kitamura K, Kohno A, Sugiura I, Yokozawa T, Hanamura A, Yamamoto K, Iida H, Emi N, Suzuki R, Ohnishi K, Naoe T.

Cancer Sci   101 巻   頁： 2186-2192   2010年10月

Imatinib for newly diagnosed chronic-phase chronic myeloid leukemia: results of a prospective study in Japan. 査読有り

Nagai T, Takeuchi J, Dobashi N, Kanakura Y, Taniguchi S, Ezaki K, Nakaseko C, Hiraoka A, Okada M, Miyazaki Y, Motoji T, Higashihara M, Tsukamoto N, Kiyoi H, Nakao S, Shinagawa K, Ohno R, Naoe T, Ohnishi K, Usui N.

Int J Hematol   92 巻   頁： 111-117   2010年7月

Array-based genomic resequencing of human leukemia. 査読有り

Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, Mano H.

Oncogene   29 巻   頁： 3723-3731   2010年6月

BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4. 査読有り

Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T.

Eur J Haematol   84 巻   頁： 229-238   2010年

Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia. 査読有り

Tsujimura A, Kiyoi H, Shiotsu Y, Ishikawa Y, Mori Y, Ishida H, Toki T, Ito E, Naoe T.

Int J Hematol   92 巻   2010年

Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. 査読有り

Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R.

J Clin Oncol   28 巻   頁： 1591-1598   2010年

Randomized trial of response-oriented individualized versus fixed-schedule induction chemotherapy with idarubicin and cytarabine in adult acute myeloid leukemia: the JALSG AML95 study. 査読有り

Ohtake S, Miyawaki S, Kiyoi H, Miyazaki Y, Okumura H, Matsuda S, Nagai T, Kishimoto Y, Okada M, Takahashi M, Handa H, Takeuchi J, Kageyama S, Asou N, Yagasaki F, Maeda Y, Ohnishi K, Naoe T, Ohno R.

Int J Hematol   91 巻   頁： 276-283   2010年

Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD / SCID / IL-2Rgammac mice. 査読有り

Tanizaki R, Nomura Y, Miyata Y, Minami Y, Abe A, Hanamura A, Sawa M, Murata M, Kiyoi H, Matsushita T, Naoe T.

Cancer Sci   101 巻   頁： 631-638   2010年

Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment. 査読有り

Minami Y, Kajiguchi T, Abe A, Ohno T, Kiyoi H, Naoe T.

Int J Hematol   92 巻   頁： 664-666   2010年

Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance. 査読有り

Hiraga J, Tomita A, Sugimoto T, Shimada K, Ito M, Nakamura S, Kiyoi H, Kinoshita T, Naoe T.

Blood   113 巻   頁： 4885-4893   2009年

Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. 査読有り

Inamoto Y, Murata M, Katsumi A, Kuwatsuka Y, Tsujimura A, Ishikawa Y, Sugimoto K, Onizuka M, Terakura S, Nishida T, Kanie T, Taji H, Iida H, Suzuki R, Abe A, Kiyoi H, Matsushita T, Miyamura K, Kodera Y, Naoe T.

Bone Marrow Transplant   45 巻   頁： 363-369   2009年

Escape mechanisms from antibody therapy to lymphoma cells: downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation. 査読有り

Sugimoto T, Tomita A, Hiraga J, Shimada K, Kiyoi H, Kinoshita T, Naoe T.

Biochem Biophys Res Commun   390 巻   頁： 48-53   2009年

CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma. 査読有り

Takeshita A, Shinjo K, Yamakage N, Ono T, Hirano I, Matsui H, Shigeno K, Nakamura S, Tobita T, Maekawa M, Ohnishi K, Sugimoto Y, Kiyoi H, Naoe T, Ohno R.

Br J Haematol   146 巻   頁： 34-43   2009年

CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells. 査読有り

Takeshita A, Yamakage N, Shinjo K, Ono T, Hirano I, Nakamura S, Shigeno K, Tobita T, Maekawa M, Kiyoi H, Naoe T, Ohnishi K, Sugimoto Y, Ohno R.

Leukemia   23 巻   頁： 1329-1336   2009年

Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia. 査読有り

Ishikawa Y, Kiyoi H, Tsujimura A, Miyawaki S, Miyazaki Y, Kuriyama K, Tomonaga M, Naoe T.

Eur J Haematol   83 巻   頁： 90-98   2009年

Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome. 査読有り

10. Xu J, Suzuki M, Niwa Y, Hiraga J, Nagasaka T, Ito M, Nakamura S, Tomita A, Abe A, Kiyoi H, Kinoshita T, Naoe T.

Br J Haematol.   140 巻   頁： 394-401   2008年

Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan. 査読有り

Narimatsu H, Iino M, Ichihashi T, Yokozawa T, Hayakawa M, Kiyoi H, Takeo T, Sawamoto A, Iida H, Tsuzuki M, Yanada M, Naoe T, Suzuki R, Sugiura I.

Int J Hematol   88 巻   2008年

Karyotypically independent clones with del(11q) and trisomy 10 in acute myeloid leukemia: trisomy 10 may appear as an additional change. 査読有り

Gotoh M, Sasaki Y, Iguchi T, Fujimoto H, Kodama A, Kiyoi H, Naoe T, Ohyashiki K.

Int J Hematol   88 巻   頁： 123-124   2008年

Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review. 査読有り

Murata M, Ishikawa Y, Ohashi H, Terakura S, Ozeki K, Kiyoi H, Naoe T.

Int J Hematol   88 巻   頁： 111-115   2008年

Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome. 査読有り

Sato T, Toki T, Kanezaki R, Xu G, Terui K, Kanegane H, Miura M, Adachi S, Migita M, Morinaga S, Nakano T, Endo M, Kojima S, Kiyoi H, Mano H, Ito E.

Br J Haematol.   141 巻   頁： 681-688   2008年

Mutations of JAK2, JAK3 and GATA1 in acute megakaryoblastic leukemia of Down syndrome. 査読有り

8. Hama A, Yagasaki H, Takahashi Y, Matsumoto K, Kiyoi H, Kojima S.

Blood   111 巻   頁： 2493-2494   2008年

Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan. 査読有り

9. Narimatsu H, Yokozawa T, Iida H, Tsuzuki M, Hayakawa M, Takeo T, Iino M, Ichihashi T, Kato C, Sawamoto A, Sao H, Yanada M, Emi N, Kiyoi H, Yamaguchi T, Naoe T, Suzuki R, Sugiura I.

Leukemia   22 巻   頁： 432-434   2008年

Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors. 査読有り

Ishida H, Isami S, Matsumura T, Umehara H, Yamashita Y, Kajita J, Fuse E, Kiyoi H, Naoe T, Akinaga S, Shiotsu Y, Arai H.

Bioorg Med Chem Lett.   18 巻   頁： 5472-5477   2008年

Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. 査読有り

Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang JY, Naoe T.

Int J Hematol   88 巻   頁： 471-475   2008年

Prognostic implication and biological roles of RhoH in acute myeloid leukaemia. 査読有り

Iwasaki T, Katsumi A, Kiyoi H, Tanizaki R, Ishikawa Y, Ozeki K, Kobayashi M, Abe A, Matsushita T, Watanabe T, Amano M, Kojima T, Kaibuchi K, Naoe T.

Eur J Haematol   81 巻   頁： 454-460   2008年

Mutational analysis of SOS1 gene in acute myeloid leukemia. 査読有り

Tanizaki R, Katsumi A, Kiyoi H, Kunishima S, Iwasaki T, Ishikawa Y, Kobayashi M, Abe A, Matsushita T, Watanabe T, Kojima T, Kaibuchi K, Kojima S, Naoe T.

Int J Hematol   88 巻   2008年

Clinical features and outcome of T-lineage acute lymphoblastic leukemia in adults: A low initial white blood cell count, as well as a high count predict decreased survival rates. 査読有り

Yanada M, Jinnai I, Takeuchi J, Ueda T, Miyawaki S, Tsuzuki M, Hatta Y, Usui N, Wada H, Morii T, Matsuda M, Kiyoi H, Okada M, Honda S, Miyazaki Y, Ohno R, Naoe T.

Leukemia Res   31 巻   2007年

FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells. 査読有り

Kajiguchi T, Chung EJ, Lee S, Stine A, Kiyoi H, Naoe T, Levis MJ, Neckers L, Trepel JB.

Leukemia   21 巻   2007年

Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan. 査読有り

Narimatsu H, Yokozawa T, Iida H, Tsuzuki M, Hayakawa M, Takeo T, Iino M, Ichihashi T, Kato C, Sawamoto A, Sao H, Yanada M, Emi N, Kiyoi H, Yamaguchi T, Naoe T, Suzuki R, Sugiura I.

Leukemia   21 巻   2007年

High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia. 査読有り

Narimatsu H, Emi N, Kohno A, Iwai M, Yanada M, Yokozawa T, Saito S, Shimada K, Kiyoi H, Naoe T, Yamamoto K, Morishita Y.

Bone Marrow Transplant   40 巻   2007年

Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma. 査読有り

Hiraga J, Katsumi A, Iwasaki T, Abe A, Kiyoi H, Matsushita T, Kinoshita T, Naoe T.

Leukemia   21 巻   2007年

Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. 査読有り

Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T.

Leukemia   21 巻   頁： 136   2007年

Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD. 査読有り

Okamoto M, Hayakawa F, Miyata Y, Watamoto K, Emi N, Abe A, Kiyoi H, Towatari M, Naoe T.

Leukemia   21 巻   頁： 403   2007年

JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. 査読有り

Kiyoi H, Yamaji S, Kojima, Naoe T.

Leukemia   21 巻   頁： 574   2007年

Epegenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with Rituximab-containing chemotherapy. 査読有り

Tomita A, Hiraga J, Kiyoi H, Ninomiya M, Sugimoto T, Ito M, Kinoshita T, Naoe T.

Int J Hematol   84 巻   2007年

A novel FLT3 inhibitor FI-700 selectively suppress the growth of leukemia cells with FLT3 mutations. 査読有り

Kiyoi H, Shiotsu Y, Ozeki K, Yamaji S, Kosugi H, Umehara H, Arai H, Ishii K, Akinaga S, Naoe T.

Clin Cancer Res   13 巻   頁： 4575-4582   2007年

Successful second cord blood transplantation using fludarabine and cyclophosphamide as a preparative regimen for graft rejection following reduced-intensity cord blood transplantation. 査読有り

Mizutani E, Narimatsu H, Murata M, Tomita A, Kiyoi H, Naoe T.

Bone Marrow Tranaplant   32 巻   2007年

A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RAR{alpha} transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study. 査読有り

Asou N, Kishimoto Y, Kiyoi H, Okada M, Kawai Y, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Kobayashi T, Ohtake S, Nishimura M, Takahashi M, Yagasaki F, Takeshita A, Kimura Y, Iwanaga M, Naoe T, Ohno R.

Blood   107 巻   2007年

LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). 査読有り

Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T.

Eur J Haematol.   78 巻   2007年

Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo. 査読有り

Atsumi A, Tomita A, Kiyoi H, Naoe T.

BBRC   345 巻   頁： 1471   2006年

FLT3 mutations in acute myeloid leukemia. 招待有り 査読有り

Kiyoi H, Naoe T.

Meth Molec Med   125 巻   頁： 189   2006年

PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. 査読有り

Yamamoto T, Isomura M, Xu Y, Liang J, Yagasaki H, Kamachi Y, Kudo K, Kiyoi H, Naoe T, Kojma S.

Leukemia Res   30 巻   頁： 1085   2006年

Mutations of N-RAS, FLT3 and p53 genes are not involved in the development of acute leukemia transformed from myeloproliferative diseases with JAK2 mutation. 査読有り

Suzuki M, Abe A, Kiyoi H, Murata M, Ito Y, Shimada K, Morishita Y, Kinoshita T, Naoe T.

Leukemia   20 巻   頁： 1168   2006年

Micafungin, a novel antifungal agent, as empirical therapy in acute leukemia patients with febrile neutropenia. 査読有り

Yanada M, Kiyoi H, Murata M, Suzuki M, Iwai M, Yokozawa T, Baba H, Emi N, Naoe T.

Intern Med   45 巻   頁： 259   2006年

Biology, clinical relevance, and moleculary targeted therapy in acute leukemia with FLT3 mutations. 招待有り 査読有り

Kiyoi H, Naoe T.

Int J Hematol   83 巻   頁： 301   2006年

Establishment of a Stroma-Dependent Human Acute Myelomonocytic Leukemia Cell Line, NAMO-2, with FLT3 Tandem Duplication. 査読有り

Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A, Emi N, Naoe T.

Int J Hematol   84 巻   頁： 328   2006年

Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. 査読有り

Karnan S, Tsuzuki S, Kiyoi H, Tagawa H, Ueda R, Seto M, Naoe T.

Gene Chromosome Canc   45 巻   頁： 420   2006年

Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation. 査読有り

Yanada M, Matsushita T, Suzuki M, Kiyoi H, Yamamoto K, Kinoshita T, Kojima T, Saito H, Naoe T.

Eur J Haematol   77 巻   頁： 282   2006年

Nucleophosmin: a versatile molecule associated with hematological malignancies. 査読有り

Naoe T, Suzuki T, Kiyoi H, Urano T.

Cancer Sci   97 巻   頁： 963   2006年

Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene. 査読有り

Ninomiya M, Abe A, Yokozawa T, Ozeki K, Yamamoto K, Ito M, Ito M, Kiyoi H, Emi N, Naoe T.

Cancer Genet Cytogen   169 巻   頁： 1   2006年

*Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia. 査読有り

Suzuki T, Kiyoi H, Ozeki K, Tomita A, Yamaji S, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Kinoshita T, Emi N, Naoe T.

Blood   106 巻   頁： 2854   2005年

Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome. 査読有り

Iwai M, Kiyoi H, Ozeki K, Kinoshita T, Emi N, Ohno R, Naoe T.

Leukemia   19 巻   頁： 1367   2005年

Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis. 査読有り

Yanada M, Matsuo K, Suzuki T, Kiyoi H, Naoe T.

Leukemia   19 巻   頁： 1345   2005年

Clinical significance of FLT3 in leukemia. 招待有り 査読有り

Kiyoi H, Yanada M, Ozeki K.

Int J Hematol   82 巻   頁： 85   2005年

BMI-1 Is Highly Expressed in M0-Subtype Acute Myeloid Leukemia. 査読有り

Sawa M, Yamamoto K, Yokozawa T, Kiyoi H, Hishida A, Kajiguchi T, Seto M, Kohno A, Kitamura K, Itoh Y, Asou N, Hamajima N, Emi N, Naoe T.

Int J Hematol   82 巻   頁： 42   2005年

Long-term outcomes for unselected patients with acute myeloid leukemia categorized according to the World Health Organization classification: a single-center experience. 査読有り

Yanada M, Suzuki M, Kawashima K, Kiyoi H, Kinoshita T, Emi N, Saito H, Naoe T.

Eur J Haematol   74 巻   頁： 418   2005年

*Biological and clinical significance of the FLT3 transcript level in acute myeloid leukemia. 査読有り

Ozeki K, Kiyoi H, Hirose Y, Iwai M, Ninomiya M, Kodera Y, Miyawaki S, Kuriyama K, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Ohno R, Emi N, Naoe T.

Blood   103 巻   頁： 1901   2004年

Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia. 査読有り

Yanada M, Terakura S, Yokozawa T, Yamamoto K, Kiyoi H, Emi N, Kitamura K, Kohno A, Tanaka M, Tobita T, Takeo T, Sao H, Kataoka T, Kobayashi M, Takeshita A, Morishita Y, Sugiura I, Naoe T.

Leukemia Lymphoma   45 巻   頁： 1803   2004年

Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line. 査読有り

Ninomiya M, Kiyoi H, Ito M, Hirose Y, Ito M, Naoe T.

Leukemia   18 巻   頁： 442   2004年

Normal and oncogenic FLT3. 招待有り 査読有り

Naoe T, Kiyoi H.

Cell Mol Life Sci   61 巻   頁： 2932   2004年

Different anti-apoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. 査読有り

Minami Y, Yamamoto K, Kiyoi H, Ueda R, Saito H, Naoe T.

Blood   102 巻   頁： 2969   2003年

Comprehensive analysis of gene alterations in acute megakaryoblastic leukemia of Down syndrome. 査読有り

Hirose Y, Kudo K, Kiyoi H, Hayashi Y, Naoe T, Kojima S.

Leukemia   17 巻   頁： 2250   2003年

A xeno-transplantable plasma cell leukemia line with a split translocation of the IgH gene. 査読有り

Ohbayashi K, Taniwaki M, Ninomiya M, Kiyoi H, Iida S, Ueda R, Naoe T.

Cancer Genet Cytogen   144 巻   頁： 31   2003年

Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy 査読有り

Leukemia   16 巻   頁： 203-208   2002年

Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11 査読有り

Leukemia   16 巻   頁： 2205-2212   2002年

Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors 査読有り

Leukemia   16 巻   頁： 1535-1540   2002年

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain 査読有り

Kiyoi H, Ohno R, Ueda R, Saito H, Naoe T.

Oncogene   21 巻   頁： 2555-2563   2002年

Rapid screening of leukemia fusion transcripts in acute leukemia by Real-time PCR. 査読有り

Osumi K, Fukui T, Kiyoi H, Kasai M, Kodera Y, Kudo K, Kato K, Matsuyama M, Naito K, Tamimoto M, Hirai H, Saito H, Ohno R, Naoe T.

Leukemia Lymphoma   43 巻   頁： 2291   2002年

FLT3 in human hematologic malignancies. 招待有り 査読有り

Kiyoi H, Naoe T.

Leukemia Lymphoma   43 巻   頁： 1541   2002年

Successful treatment with imatinib mesylate of a CML patient in megakaryoblastic crisis with severe fibrosis. 査読有り

Hirose Y, Kiyoi H, Iwai M, Yokozawa T, Ito M, Naoe T.

Int J Hematol   76 巻   頁： 349   2002年

Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations 査読有り

Jpn J Cancer Res   92 巻   頁： 638-644   2001年

B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells 査読有り

Immunology   104 巻   頁： 410-417   2001年

FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy 査読有り

Cancer Chemother Pharmacol   48 巻   頁： 27-30   2001年

Immunoglobulin variable region structure and B cell malignancies. 査読有り

Kiyoi H, Naoe T.

Int J Hematol   73 巻   頁： 47   2001年

Prognostic significance of the cell cycle inhibitor p27Kip1 in acute myeloid leukemia.

Leukemia   14 巻   頁： 28-33   2000年

Leukemia relapse reconsidered from the molecular aspect.

Leukemia and Lymphoma   37 巻   頁： 527-534   2000年

Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid.

Br J Haematol   108 巻   頁： 696-702   2000年

Identification of a novel putative Ran-binding protein and its close homologue

Biochem Biophys Res Commun   278 巻   頁： 241-249   2000年

Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia. 査読有り

Clin Cancer Res   6 巻   頁： 4091-4095   2000年

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. 査読有り

Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T.

Oncogene   19 巻   頁： 624-631   2000年

Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia.

Eur J Haematol   65 巻   頁： 23-31   2000年

In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor.

Leukemia   14 巻   頁： 374-378   2000年

Poor clinical significance of p53 gene polymorphism in acute myeloid leukemia.

Leuk Res   24 巻   頁： 349-352   2000年

Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis. 査読有り

Kitamura K, Minami Y, Yamamoto K, Akao Y, Kiyoi H, Saito H, Naoe T.

Leukemia   14 巻   頁： 1743   2000年

Review of the immunoglobulin light chain variable region sequences from multiple myeloma cells.

Leukemia   13 巻   頁： 829-830   1999年

Accurate quantitation of residual tumor burden at bone marrow harvest predicts timing of subsequent relapse in patients with common ALL treated by autologous bone marrow transplantation. Nagoya BMT Group.

Bone Marrow Transplant   24 巻   頁： 777-784   1999年

Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy.

Leukemia   13 巻   頁： 1316-1324   1999年

Molecular evolution of acute myeloid leukaemia in relapse : unstable N-ras and FLT3 genes compared with p53 gene.

Br J Haematol   104 巻   頁： 659-664   1999年

Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation.

Leukemia   13 巻   頁： 585-589   1999年

Etoposide-realted acute promyelocytic leukemia.

Leukemia   12 巻   頁： 1171-1175   1998年

Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia.

Br J Haematol   101 巻   頁： 521-528   1998年

Characterization of the immunoglobulin light chain variable region gene expressed in multiple myeloma.

Leukemia   12 巻   頁： 601-609   1998年

Prognostic significance of TEL/AML1 fusion transcript in childhood B-precursor acute lymphoblastic leukemia.

J Pediatr Hematolo/oncolo   20 巻   頁： 190-195   1998年

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines.

Leukemia   11 巻   頁： 1605-1609   1997年

Comparison of the immunoglobulin gene transcripts between immature B lineage acute lymphoblastic leukemia and the normal phenotypic counterparts in the bone marrow.

Leukemia   11 巻   頁： 1274-1280   1997年

Unusual feature of the T-cell receptor genes in T-lineage acute lymphoblastic leukemia.

Leuk Res   21 巻   頁： 667-674   1997年

New retinoids and arsenic compounds for the treatment of refractory acute promyelocytic leukemia : clinical and basic studies for the next generation.

Cancer Chemotherapy & Pharmacology   40 巻   頁： S36-S41   1997年

Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia.

Leukemia   11 巻   頁： 1447-1452   1997年

Mutant AF-2 domain of PML-RARα in retinoic acid-resistant NB4 cells : differentiation induced by RA is triggered directly through PML-RARα and its down-regulation in acute promyelocytic leukemia.

Leukemia   11 巻   頁： 1950-1956   1997年

Comparable gene structure of the immunoglobulin heavy chain variable region between multiple myeloma and normal bone marrow lymphocytes.

Leukemia   10 巻   頁： 1804-1812   1996年

Different T-cell receptor repertoires between lesions and peripheral blood in acute graft-versus-host disease after allogeneic bone marrow transplantation.

Blood   87 巻   頁： 3019-3026   1996年

Comparison of the immunoglobulin heavy-chain complementarity determining region-3 structure among the DNA sequences and the μ-and γ-transcripts in human B-lineage cells.

Immunology   89 巻   頁： 324-330   1996年

Comparable profiles of the immunoglobulin heavy chain complementarity determining region(CDR)-3 in CD5₊ and CD5_- human cord blood B lymphocytes.

Immunology   85 巻   頁： 236-240   1995年

Detection of minimal residual disease in patients with childhood common acute lymphoblastic leukemia after autologous bone marrow trasplantation with ex vivo purging and systemic IL-2 infusion : unsuccessful prediction of subsequent relapse.

Bone Marrow Transplant   16 巻   頁： 437-442   1995年

Continuing immunoglobulin heavy chain gene rearrangements in chronic myeloid leikemia with recurrent B-lymphoid blast crises after bone marrow transplantation.

Leukemia   9 巻   頁： 265-270   1995年

Analysis of the joining sequences of the t(15 ; 17)translocation in human acute pronyelocytic leukemia : sequence non-specific recombination between the PML and RARA genes within identical short stretches.

Genes, Chromosomes & Cancer   12 巻   頁： 37-44   1995年

Prognostic significance of the RT-PCR assay of PML-RARA trascripts in acute promyelocytic leukemia.

Leukemia   9 巻   頁： 588-593   1995年

Characterization of immunoglobulin heavy chain gene rearrangements in chronic myeloid leikemia with recurrent B-lymphoid blast crisis following bone marrow transplantation.

Int Med   33 巻   頁： 786-789   1994年

Minimal residual disease status in pre-B acute lymphoblastic leukemia patients after chemotherapy and bone marrow trasplantation : assessment of the antileukemic effects of chemotherapy and BMT.

Leuk Res   17 巻   頁： 674-684   1993年

Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia.

Jap J Cancer Res   84 巻   頁： 379-387   1993年

Involvement of the MLL/ALL-1 gene associated with multiple point mutations of the N-ras gene in acute myeloid leukemia with t(11 : 17)(q23 ; q25).

Blood   82 巻   頁： 2260-2261   1993年

Effective treatment of adult T cell leukemia/lymphoma with a novel oral antitumor agent, MST-16.

Oncology   49 巻   頁： 333-335   1992年

Hermolytic uraemic syndrome during FK506 therapy.

Lancet   340 巻   頁： 60-61   1992年

Development of hyperthyroidism in donor and recipient after allogeneic bone marrow transplantation.

Bone Marrow Transplant   10 巻   頁： 397-398   1992年

Characterization of the immunoglobulin heavy chain complementarity determining region(CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells. 査読有り

J Clin Invest   89 巻   頁： 739-746   1992年

Disappearance of minimal residual lymphoblastic leukemia cells 6 months after allogeneic bone marrow transplantation without GVHD. 査読有り

Bone Marrow Transplant   8 巻   頁： 59-62   1991年

A case of cALL relapse after allogeneic BMT : recurrence of recipient cell origin, initially determined as being that of donor cell origin by sex chromosome analysis. 査読有り

Br J Haematolo   73 巻   頁： 420-422   1989年

造血器腫瘍治療第2版　これは困ったぞ, どうしよう！・AMLのリスク分類とそれに基づく治療選択の現状は？

清井　仁（ 担当： 共著）

中外医学社  2010年 

がんの分子標的と治療薬事典・FLT3

清井　仁（ 担当： 共著）

羊土社  2010年 

臨床に直結する血液疾患診療のエビデンス・急性骨髄性白血病の予後因子

清井　仁（ 担当： 共著）

文光堂  2009年 

WHO分類第4版による白血病・リンパ系腫瘍の病態学・急性骨髄性白血病および関連前駆細胞性腫瘍

清井　仁、直江知樹（ 担当： 共著）

中外医学社  2009年 

造血器腫瘍アトラス　形態、免疫、染色体と遺伝子　第4版・急性骨髄性白血病におけるNPM1遺伝子突然変異

清井　仁（ 担当： 共著）

日本医事新報社  2009年 

講義録　血液・造血器疾患学　フローサイトメトリ

清井　仁（ 担当： 共著）

メジカルビュー社  2008年 

新しい診断と治療のABC・急性白血病・病因

清井　仁（ 担当： 共著）

最新医学社  2006年 

分子標的療法の基礎と臨床・FLT3を標的にした白血病の治療

清井　仁、直江知樹（ 担当： 共著）

篠原出版新社  2005年 

分子標的治療薬「作用機序と臨床」・細胞内シグナル伝達系を阻害する薬剤、チロシンキナーゼ阻害剤/FLT3阻害剤（MLN518, PKC412, CEP-701）

清井　仁（ 担当： 共著）

メディカルレビュー社  2005年 

血液・固形腫瘍診断マニュアル改定版・タンパク分析法

清井　仁（ 担当： 共著）

フジメディカル出版  2002年 

臨床血液実験操作法・免疫グロブリン遺伝子を用いたクローナリティーの解析

清井　仁（ 担当： 共著）

科学評論社  2000年 

血液・固形腫瘍診断マニュアル・タンパク分析法

清井　仁（ 担当： 共著）

フジメディカル出版  2000年 

別冊・医学のあゆみ：血液疾患-state of arts Ver. 2免疫グロブリン遺伝子による微量残存白血病の診断

清井　仁（ 担当： 共著）

医歯薬出版  1998年 

図説臨床癌シリーズno. 17　白血病・リンパ腫　新版minimal residual disease (MRD)の検出とその意義

清井　仁、大野竜三（ 担当： 共著）

メジカルビュー社  1994年 

免疫グロブリン遺伝子による微量残存白血病の診断、溝口秀昭、平井久丸、坂田洋一編集、別冊・医学のあゆみ：血液疾患-state of arts

清井　仁（ 担当： 共著）

医歯薬出版  1993年 

Polymerase chain reaction for the detection of minimal residual B-cell clones using diversity of complementarity determining region (CDR) III. In “Cancer Chemotherapy: Challenges for the Future Volume 6” (Ed.)

Naoe T. Kiyoi H. Ohno R（ 担当： 共著）

Excerpta Medica  1991年 

Current review　癌化学療法1990～91各臓器癌の化学療法：白血病・骨髄腫

清井　仁、山田一正（ 担当： 共著）

中外医学社  1990年 

造血器腫瘍の病態に基づいた新規治療薬の選択】再発・難治性のB細胞性急性リンパ性白血病に対する二重特異性T細胞誘導(BiTE)抗体ブリナツモマブ 招待有り

川島直実、清井仁  

血液内科81 巻 ( 1 ) 頁： 30 - 34   2020年7月

【急性白血病-最新の診断と治療-】開発中の薬剤　FLT3阻害薬 招待有り

川島直実、清井仁  

日本臨床 78 巻 ( 3 ) 頁： 499 - 506   2020年3月

【病気とくすり2020　基礎と実践Expert's Guide】病原微生物・悪性新生物とくすり　悪性腫瘍　白血病 招待有り

中島 麻梨絵, 石川 裕一, 清井 仁  

薬局71 巻 ( 4 ) 頁： 2061 - 2069   2020年3月

【病気とくすり2020　基礎と実践Expert's Guide】病原微生物・悪性新生物とくすり　悪性腫瘍　悪性リンパ腫 招待有り

村瀬 篤史, 島田 和之, 清井 仁  

薬局71 巻 ( 4 ) 頁： 2070 - 2077   2020年3月

【病気とくすり2020　基礎と実践Expert's Guide】病原微生物・悪性新生物とくすり　悪性腫瘍　多発性骨髄腫 招待有り

牛島洋子、清井仁  

薬局71 巻 ( 4 ) 頁： 2070 - 2077   2020年3月

【白血病治療薬開発の現況】FLT3阻害薬 招待有り

清井仁  

医学と薬学77 巻 ( 2 ) 頁： 205 - 211   2020年1月

The efficacy of anti-PD-1 antibody for IVLBCL in humanized immune system mouse model

Takai, M; Shimada, K; Kiyoi, H

CANCER SCIENCE  2024年3月 

Analysis of Metabolic Mechanism of CD19CAR-T with CD79A/CD40 Co-Stimulatory Domain Based on Comparison with Established CAR-Ts 国際会議

Takeuchi, Y; Terakura, S; Hirano, S; Yokota, H; Kuwano, S; Osaki, M; Adachi, Y; Imai, K; Julamanee, J; Hanajiri, R; Murata, M; Kiyoi, H

BLOOD  2023年11月2日 

Thrombotic and Bleeding Events in Japanese Adolescent and Young Adult PV and ET: Results from Japanese Multicenter Retrospective Study 国際会議

Sugimoto, Y; Nagaharu, K; Oya, E; Ohishi, K; Tawara, I; Ito, T; Gotoh, A; Nakamae, M; Kimura, F; Koike, M; Kirito, K; Wada, H; Usuki, K; Tanaka, T; Mori, T; Wakita, S; Saito, TI; Kada, A; Saito, AM; Shimoda, K; Kurokawa, T; Tomita, A; Edahiro, Y; Hashimoto, Y; Kiyoi, H; Akashi, K; Matsumura, I; Takenaka, K; Komatsu, N

BLOOD  2023年11月2日 

Suppression of Super-Enhancer-Driven TAL1 Expression By KLF4 in T-Cell Acute Lymphoblastic Leukemia 国際会議

Noura, M; Yasuda, T; Tsuzuki, S; Matsuo, H; Kiyoi, H; Hayakawa, F

BLOOD  2023年11月2日 

Real-World Data in a Prospective Clinical Observation Study for Newly Diagnosed Adult Acute Lymphoblastic Leukemia, the JALSG ALL-CS-12: Advanced Age Is a Poor Prognostic Factor 国際会議

Hatta, Y; Hayakawa, F; Yamazaki, E; Murayama, T; Saito, T; Takada, S; Dobashi, N; Ota, S; Yokoyama, Y; Tanaka, M; Sato, S; Ohtake, S; Sakaida, E; Maeda, Y; Yamauchi, T; Matsumura, I; Miyazaki, Y; Kiyoi, H

BLOOD  2023年11月2日 

Development and Efficacy of a Novel Bromodomain and Extraterminal Domain Degrader K-256 in MYC/BCL2-Related Lymphoma 国際会議

Furukawa, K; Shimada, K; Esaki, M; Tanaka, K; Yamamoto, K; Mori, K; Kiyoi, H

BLOOD  2023年11月2日 

Novel CAR-T cell therapy for solid tumors targeting epithelial V-like antigen 1

Osaki, M; Terakura, S; Sunagawa, M; Kokuryo, T; Nishida, T; Murata, M; Kiyoi, H

CANCER SCIENCE  2023年2月 

The efficacy of BTK inhibitor in IVLBCL preclinical mouse models.

Takai, M; Shimada, K; Kiyoi, H

CANCER SCIENCE  2023年2月 

NDRG2はびまん性大細胞型B細胞リンパ腫の中枢神経病変において高発現を来す

村瀨篤史、島田和之、青木智広、真田昌、中杤昌弘、島田聡子、久納俊祐、中村栄男、清井仁

第82回日本血液学会学術集会  2020年10月10日 

Comparison of drug sensitivity and resistance to FLT3 inhibitors in FLT3 mutated AML-PDX models

2020年10月10日 

Upregulation of adhesion molecules associates with PDX-specific clonal expansion and R/R AML.

2020年10月10日 

Phase I study of cord blood transplantation with intra-bone marrow injection of MSC.

Goto T, Murata M, Nishida T, Terakura S, Kamoshita S, Ishikawa Y, Ushijima Y, Adachi Y, Kato K, Hirakawa A, Nishiwaki S, Nishio N, Takahashi Y, Kodera Y, Matsushita T, Kiyoi H.

2020年10月10日 

Optimization of antigen recognition in the development of anti-CD37 chimeric antigen receptor T cell

Okuno S, Adachi Y, Terakura S, Julamanee J, Sakai T, Nishida T, Murata M, Kiyoi H.

2020年10月10日