日本輸血・細胞療法学会

American Society of Hematology

European Hematology Association

小林がん学術振興会　先駆的研究賞

2012   小林がん学術振興会  

日本白血病研究基金　一般研究賞

2000   日本白血病研究基金  

武田科学振興財団　一般研究奨励賞

1999   武田科学振興財団  

上原記念生命科学財団　研究奨励賞

1997   上原記念生命科学財団  

Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment. Reviewed

Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T.

Blood   Vol. 118   page： 1600-1609   2011

KW-2449, a novel multi-kinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Reviewed

Shiotsu Y*, Kiyoi H*, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T.

Blood   Vol. 114   page： 1607-1617   2009

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies Reviewed

Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Saito K, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Saito H, Ueda R, Ohno R, and Naoe T.

Blood   Vol. 97   page： 2434-2439   2001

Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Reviewed

Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R.

Blood   Vol. 93   page： 3074-3080   1999

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Reviewed

Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H, Naoe T.

Leukemia   Vol. 12   page： 1333-1337   1998

Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells Reviewed International journal

Kawashima Naomi, Ishikawa Yuichi, Kim Jeong Hui, Ushijima Yoko, Akashi Akimi, Yamaguchi Yohei, Hattori Hikaru, Nakashima Marie, Ikeno Seara, Kihara Rika, Nishiyama Takahiro, Morishita Takanobu, Watamoto Koichi, Ozawa Yukiyasu, Kitamura Kunio, Kiyoi Hitoshi

NATURE COMMUNICATIONS   Vol. 13 ( 1 ) page： 1624   2022.3

Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma Reviewed International journal

Shimada Kazuyuki, Yoshida Kenichi, Suzuki Yasuhiro, Iriyama Chisako, Inoue Yoshikage, Sanada Masashi, Kataoka Keisuke, Yuge Masaaki, Takagi Yusuke, Kusumoto Shigeru, Masaki Yasufumi, Ito Takahiko, Inagaki Yuichiro, Okamoto Akinao, Kuwatsuka Yachiyo, Nakatochi Masahiro, Shimada Satoko, Miyoshi Hiroaki, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Shiozawa Yusuke, Nannya Yasuhito, Okabe Asako, Kohno Kei, Atsuta Yoshiko, Ohshima Koichi, Nakamura Shigeo, Ogawa Seishi, Tomita Akihiro, Kiyoi Hitoshi

BLOOD   Vol. 137 ( 11 ) page： 1491 - 1502   2021.3

Allogeneic hematopoietic stem cell transplantation at the first remission for younger adults with FLT3-internal tandem duplication AML: The JALSG AML209-FLT3-SCT study. Reviewed International journal

Kawashima N, Ishikawa Y, Atsuta Y, Sawa M, Ozawa Y, Hayashi M, Kohno A, Tomita A, Maeda T, Sakaida E, Usuki K, Hagihara M, Kanamori H, Matsuoka H, Kobayashi M, Asou N, Ohtake S, Matsumura I, Miyazaki Y, Naoe T, Kiyoi H, Japan Adult Leukemia Study Group (JALSG).

Cancer science   Vol. 111 ( 7 ) page： 2472 - 2481   2020.7

Newly diagnosed multiple myeloma with bleeding and coagulation abnormalities caused by a thrombin-inhibiting substance Reviewed International journal

Ohara, F; Suzuki, A; Suzuki, N; Kanematsu, T; Okamoto, S; Tamura, S; Kiyoi, H; Matsushita, T; Katsumi, A

INTERNATIONAL JOURNAL OF HEMATOLOGY     2024.9

Recent advances in AML with mutated <i>NPM1</i> Invited Reviewed International journal

Ishikawa, Y; Ushijima, Y; Kiyoi, H

INTERNATIONAL JOURNAL OF HEMATOLOGY     2024.8

Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis (JUL, 10.1007/s00277-024-05898-3, 2024) Reviewed International journal

Nagaharu, K; Ohya, E; Edahiro, Y; Hashimoto, Y; Ito, T; Gotoh, A; Nakamae, M; Kimura, F; Koike, M; Kirito, K; Wada, H; Usuki, K; Tanaka, T; Mori, T; Wakita, S; Saito, TI; Saito, AM; Shimoda, K; Kurokawa, T; Tomita, A; Kiyoi, H; Akashi, K; Matsumura, I; Takenaka, K; Komatsu, N; Ohishi, K; Tawara, I; Sugimoto, Y

ANNALS OF HEMATOLOGY     2024.8

Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis Reviewed International journal

Nagaharu, K; Ohya, E; Edahiro, Y; Hashimoto, Y; Ito, T; Gotoh, A; Nakamae, M; Kimura, F; Koike, M; Kirito, K; Wada, H; Usuki, K; Tanaka, T; Mori, T; Wakita, S; Saito, TI; Saito, AM; Shimoda, K; Kurokawa, T; Tomita, A; Kiyoi, H; Akashi, K; Matsumura, I; Takenaka, K; Komatsu, N; Ohishi, K; Tawara, I; Sugimoto, Y

ANNALS OF HEMATOLOGY   Vol. 103 ( 9 ) page： 3535 - 3541   2024.7

Initiating-clone analysis in patients with acute myeloid leukemia secondary to essential thrombocythemia Reviewed International journal

Ushijima, Y; Naruse, S; Ishikawa, Y; Kawashima, N; Sanada, M; Nakashima, M; Kim, JH; Terakura, S; Kihara, R; Watamoto, K; Nishiyama, T; Kitamura, K; Matsushita, T; Kiyoi, H

SCIENTIFIC REPORTS   Vol. 14 ( 1 ) page： 15906   2024.7

Nilotinib vs. Dasatinib in Achieving MR4.5 for de novo Chronic Myeloid Leukemia: the Randomized JALSG CML212 Study. Reviewed International journal

Matsumura I, Ohtake S, Atsuta Y, Kurata M, Minami Y, Takahashi N, Nakaseko C, Iriyama N, Fujimaki K, Kakihana K, Ogasawara Y, Ono T, Okada M, Tauchi T, Miyamoto T, Ohnishi K, Sakaida E, Fujisawa S, Kobayashi Y, Asou N, Naoe T, Kiyoi H, Miyazaki Y

Blood advances     2024.7

NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation Reviewed International journal

Noura, M; Tomita, S; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

CANCER MEDICINE   Vol. 13 ( 13 ) page： e7445   2024.7

<i>RGS1</i> and <i>CREB5</i> are direct and common transcriptional targets of ZNF384-fusion proteins Reviewed International journal

Yamada, C; Okada, K; Odaira, K; Tokoro, M; Iwamoto, E; Sanada, M; Noura, M; Okamoto, S; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

CANCER MEDICINE   Vol. 13 ( 14 ) page： e7471   2024.7

Human iPSC-derived CD4+Treg-like cells engineered with chimeric antigen receptors control GvHD in a xenograft model Reviewed International journal

Yano, H; Koga, K; Sato, T; Shinohara, T; Iriguchi, S; Matsuda, A; Nakazono, K; Shioiri, M; Miyake, Y; Kassai, Y; Kiyoi, H; Kaneko, S

CELL STEM CELL   Vol. 31 ( 6 ) page： 795 - 802.e6   2024.6

Phase II study in children and adults under 40 years with newly diagnosed Langerhans cell histiocytosis: protocol for an LCH-19-MSMFB clinical trial in Japan Reviewed International journal

Ono, R; Sakamoto, K; Kudo, K; Sato, A; Kudo, K; Fujino, H; Kawahara, Y; Hashimoto, H; Doi, T; Yanagisawa, R; Kawamata, T; Miyazaki, O; Nakazawa, A; Ota, Y; Kanegane, H; Nakazawa, Y; Horibe, K; Saito, AM; Manabe, A; Usuki, K; Kiyoi, H; Morimoto, A; Tojo, A; Shioda, Y

BMJ OPEN   Vol. 14 ( 6 ) page： e084159   2024.6

Clonal evolution process from essential thrombocythemia to acute myeloid leukemia in the original patient from whom the CALR-mutated Marimo cell line was established. Reviewed International journal

Ushijima Y, Ishikawa Y, Nishiyama T, Kawashima N, Kanamori T, Sanada M, Kiyoi H

Nagoya journal of medical science   Vol. 86 ( 2 ) page： 326 - 332   2024.5

A phase 1/2 study of NS-87/CPX-351 (cytarabine and daunorubicin liposome) in Japanese patients with high-risk acute myeloid leukemia Reviewed International journal

Usuki, K; Miyamoto, T; Yamauchi, T; Ando, K; Ogawa, Y; Onozawa, M; Yamauchi, T; Kiyoi, H; Yokota, A; Ikezoe, T; Katsuoka, Y; Takada, S; Aotsuka, N; Morita, Y; Ishikawa, T; Asada, N; Ota, S; Dohi, A; Morimoto, K; Imai, S; Kishimoto, U; Akashi, K; Miyazaki, Y

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 119 ( 6 ) page： 647 - 659   2024.3

Utility of allogeneic stem cell transplantation for adult Ph plus ALL with complete molecular remission Reviewed International journal

Nishiwaki, S; Sugiura, I; Fujisawa, S; Hatta, Y; Atsuta, Y; Doki, N; Kurahashi, S; Ueda, Y; Dobashi, N; Maeda, T; Matsumura, I; Tanaka, M; Kako, S; Ichinohe, T; Fukuda, T; Ohtake, S; Ishikawa, Y; Miyazaki, Y; Kiyoi, H

AMERICAN JOURNAL OF HEMATOLOGY     2024.2

Suppression of super-enhancer-driven <i>TAL1</i> expression by KLF4 in T-cell acute lymphoblastic leukemia Reviewed International journal

Noura, M; Matsuo, H; Yasuda, T; Tsuzuki, S; Kiyoi, H; Hayakawa, F

ONCOGENE   Vol. 43 ( 6 ) page： 447 - 456   2024.2

Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation Reviewed International journal

Sagou, K; Sato, Y; Okuno, Y; Watanabe, T; Inagaki, T; Motooka, Y; Toyokuni, S; Murata, T; Kiyoi, H; Kimura, H

PLOS PATHOGENS   Vol. 20 ( 2 ) page： e1011954   2024.2

Real-world data of MDS and CMML in Japan: results of JALSG clinical observational study-11 (JALSG-CS-11) Reviewed International journal

Usuki, K; Ohtake, S; Honda, S; Matsuda, M; Wakita, A; Nawa, Y; Takase, K; Maeda, A; Sezaki, N; Yokoyama, H; Takada, S; Hirano, D; Tomikawa, T; Sumi, M; Yano, S; Handa, H; Ota, S; Fujita, H; Fujimaki, K; Mugitani, A; Kojima, K; Kajiguchi, T; Fujimoto, K; Asou, N; Usui, N; Ishikawa, Y; Katsumi, A; Matsumura, I; Miyazaki, Y; Kiyoi, H

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 119 ( 2 ) page： 130 - 145   2024.2

Clonal hematopoiesis of a novel dic(18;20) clone following allogeneic hematopoietic stem cell transplantation Reviewed International journal

Ito, M; Fukushima, N; Fujii, T; Numata, M; Morikawa, S; Kawamura, Y; Goto, M; Kohno, A; Imahashi, N; Yasuda, T; Sanada, M; Ishikawa, Y; Kiyoi, H; Ozeki, K

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 119 ( 1 ) page： 80 - 87   2024.1

Real-world data of AML in Japan: results of JALSG clinical observational study-11 (JALSG-CS-11) Reviewed International journal

Usuki, K; Ohtake, S; Honda, S; Matsuda, M; Wakita, A; Nawa, Y; Takase, K; Maeda, A; Sezaki, N; Yokoyama, H; Takada, S; Hirano, D; Tomikawa, T; Sumi, M; Yano, S; Handa, H; Ota, S; Fujita, H; Fujimaki, K; Mugitani, A; Kojima, K; Kajiguchi, T; Fujimoto, K; Asou, N; Usui, N; Ishikawa, Y; Katsumi, A; Matsumura, I; Kiyoi, H; Miyazaki, Y

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 119 ( 1 ) page： 24 - 38   2024.1

Outcomes of transplant-eligible patients with myelodysplastic syndrome with excess blasts registered in an observational study: The JALSG-CS11-MDS-SCT Reviewed International journal

Nakagawa, N; Ishiyama, K; Usuki, K; Takada, S; Tomikawa, T; Handa, H; Katsuoka, Y; Hirano, D; Sezaki, N; Sumi, M; Fujisawa, S; Taniguchi, Y; Mugitani, A; Yoshimura, T; Ohtsuka, E; Takase, K; Suehiro, Y; Ota, S; Kajiguchi, T; Maeda, T; Yamamoto, M; Ohtake, S; Katsumi, A; Kiyoi, H; Matsumura, I; Miyazaki, Y

ANNALS OF HEMATOLOGY   Vol. 103 ( 1 ) page： 307 - 320   2024.1

Dual CAR-T cells targeting CD19 and CD37 are effective in target antigen loss B cell tumor models. Reviewed

Imai K, Takeuchi Y, Terakura S, Okuno S, Adachi Y, Osaki M, Umemura K, Hanajiri R, Shimada K, Murata M, Kiyoi H

Molecular cancer therapeutics     2023.10

Antibody response after third dose of COVID-19 mRNA vaccination in allogeneic hematopoietic stem cell transplant recipients is comparable to that in healthy counterparts Reviewed International journal

Takagi Erina, Terakura Seitaro, Fujigaki Hidetsugu, Okamoto Akinao, Miyao Kotaro, Sawa Masashi, Morishita Takanobu, Goto Tatsunori, Ozawa Yukiyasu, Nishida Tetsuya, Fukushima Nobuaki, Ozeki Kazutaka, Hanajiri Ryo, Saito Kuniaki, Murata Makoto, Tomita Akihiro, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 118 ( 4 ) page： 462 - 471   2023.10

Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation. Reviewed International journal

Kurayoshi K, Takase Y, Ueno M, Ohta K, Fuse K, Ikeda S, Watanabe T, Nishida Y, Horike SI, Hosomichi K, Ishikawa Y, Tadokoro Y, Kobayashi M, Kasahara A, Jing Y, Shoulkamy MI, Meguro-Horike M, Kojima K, Kiyoi H, Sugiyama H, Nagase H, Tajima A, Hirao A

Cell death & disease   Vol. 14 ( 9 ) page： 642   2023.9

Improved long-term net survival after allogeneic hematopoietic cell transplantation in patients with hematologic malignancies over two decades. Reviewed International journal

Ohbiki M, Ito Y, Inamoto Y, Miyamura K, Uchida N, Fukuda T, Fujiwara H, Nishida T, Hayashi M, Tanaka M, Kawakita T, Ikegame K, Katayama Y, Ara T, Ichinohe T, Kiyoi H, Matsuo K, Atsuta Y

Transplantation and cellular therapy     2023.9

Clinicopathological characteristics associated with the engraftment of patient lymphoma cells in NOG mice Reviewed International journal

Sahashi Satomi, Shimada Kazuyuki, Takagi Yusuke, Aoki Tomohiro, Kunou Shunsuke, Sakamoto Akihiko, Murase Atsushi, Furukawa Katsuya, Kagaya Yusuke, Yamaga Yusuke, Takai Mika, Tokuyama Kiyonobu, Shimada Satoko, Nakamura Shigeo, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 118 ( 2 ) page： 221 - 230   2023.8

EBF1-JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity Reviewed International journal

Kojima Yukino, Kawashima Fumika, Yasuda Takahiko, Odaira Koya, Inagaki Yuichiro, Yamada Chiharu, Muraki Ami, Noura Mina, Okamoto Shuichi, Tamura Shogo, Iwamoto Eisuke, Sanada Masashi, Matsumura Itaru, Miyazaki Yasushi, Kojima Tetsuhito, Kiyoi Hitoshi, Tsuzuki Shinobu, Hayakawa Fumihiko

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 118 ( 1 ) page： 65 - 74   2023.7

High-risk Combinations of Additional Chromosomal Abnormalities in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia: JALSG Ph plus ALL TKI-SCT Study

Nishiwaki Satoshi, Sugiura Isamu, Fujisawa Shin, Hatta Yoshihiro, Atsuta Yoshiko, Doki Noriko, Kurahashi Shingo, Ueda Yasunori, Dobashi Nobuaki, Maeda Tomoya, Taniguchi Yasuhiro, Tanaka Masatsugu, Kako Shinichi, Ichinohe Tatsuo, Fukuda Takahiro, Ohtake Shigeki, Ishikawa Yuichi, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

HEMASPHERE   Vol. 7 ( 6 ) page： e899   2023.6

Nelarabine, intensive L-asparaginase, and protracted intrathecal therapy for newly diagnosedT-cell acute lymphoblastic leukaemia in children and young adults (ALL-T11): a nationwide, multicenter, phase 2 trial including randomisation in the very high-risk group Reviewed International journal

Sato Atsushi, Hatta Yoshihiro, Imai Chihaya, Oshima Koichi, Okamoto Yasuhiro, Deguchi Takao, Hashii Yoshiko, Fukushima Takashi, Hori Toshinori, Kiyokawa Nobutaka, Kato Motohiro, Saito Shoji, Anami Kenichi, Sakamoto Tatsuhiro, Kosaka Yoshiyuki, Suenobu Souichi, Imamura Toshihiko, Kada Akiko, Saito Akiko M., Manabe Atsushi, Kiyoi Hitoshi, Matsumura Itaru, Koh Katsuyoshi, Watanabe Arata, Miyazaki Yasushi, Horibe Keizo

LANCET HAEMATOLOGY   Vol. 10 ( 6 ) page： 419 - 432   2023.6

Autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia is safe but poses challenges for long-term maintenance of molecular remission: Results of the Auto-Ph17 study. Reviewed International journal

Nishiwaki S, Sugiura I, Sato T, Kobayashi M, Osaki M, Sawa M, Adachi Y, Okabe M, Saito S, Morishita T, Kohno A, Nishiyama T, Iida H, Kurahashi S, Kuwatsuka Y, Sugiyama D, Ito S, Nishikawa H, Kiyoi H

EJHaem   Vol. 4 ( 2 ) page： 358 - 369   2023.5

A never-ending FLT3 story Invited Reviewed International journal

Kiyoi, H

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 1 ) page： 27 - 29   2023.2

BCL6 inhibition ameliorates resistance to ruxolitinib in <i>CRLF2</i>-rearranged acute lymphoblastic leukemia Reviewed International journal

Tsuzuki Shinobu, Yasuda Takahiko, Goto Hiroaki, Maeda Naoko, Akahane Koshi, Inukai Takeshi, Yamamoto Hideyuki, Karnan Sivasundaram, Ota Akinobu, Hyodo Toshinori, Konishi Hiroyuki, Hosokawa Yoshitaka, Kiyoi Hitoshi, Hayakawa Fumihiko

HAEMATOLOGICA   Vol. 108 ( 2 ) page： 394 - 408   2023.2

The usefulness of tranexamic acid for bleeding symptoms of chronic consumptive coagulopathy complicated by aortic disease: a single-institute, retrospective study of 14 patients Reviewed International journal

Suzuki Naruko, Suzuki Nobuaki, Kawaguchi Yuka, Okamoto Shuichi, Kanematsu Takeshi, Katsumi Akira, Suzuki Atsuo, Tamura Shogo, Kojima Tetsuhito, Kiyoi Hitoshi, Matsushita Tadashi

THROMBOSIS JOURNAL   Vol. 21 ( 1 ) page： 10   2023.1

[Cellular kinetics and outcome of tisagenlecleucel for diffuse large B-cell lymphoma]. Reviewed

Hanajiri R, Furukawa K, Nakashima M, Ushijima Y, Shimada K, Ishikawa Y, Terakura S, Murata M, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 64 ( 3 ) page： 167 - 174   2023

Functional inhibition of MEF2 by C/EBP is a possible mechanism of leukemia development by CEBP-IGH fusion gene Reviewed International journal

Odaira Koya, Yasuda Takahiko, Okada Kentaro, Shimooka Takuya, Kojima Yukino, Noura Mina, Tamura Shogo, Kurahashi Shingo, Iwamoto Eisuke, Sanada Masashi, Matsumura Itaru, Miyazaki Yasushi, Kojima Tetsuhito, Kiyoi Hitoshi, Tsuzuki Shinobu, Hayakawa Fumihiko

CANCER SCIENCE   Vol. 114 ( 3 ) page： 781 - 792   2022.11

Methods for confirming the safety of radiation therapy in patients with left ventricular assist device: a case of extranodal NK/T-cell lymphoma, nasal type Reviewed International journal

Oishi Hideo, Kondo Toru, Kawamura Mariko, Shimada Kazuyuki, Mutsuga Masato, Kurokawa Takashi, Kuwayama Tasuku, Hiraiwa Hiroaki, Morimoto Ryota, Okumura Takahiro, Nishida Tetsuya, Kiyoi Hitoshi, Naganawa Shinji, Usui Akihiko, Murohara Toyoaki

JOURNAL OF ARTIFICIAL ORGANS   Vol. 25 ( 3 ) page： 274 - 278   2022.9

Prospective comparison of 5-and 7-day administration of azacitidine for myelodysplastic syndromes: a JALSG MDS212 trial Reviewed International journal

Miyazaki Yasushi, Kiguchi Toru, Sato Shinya, Usuki Kensuke, Ishiyama Ken, Ito Yoshikazu, Suzuki Takahiro, Taguchi Jun, Chiba Shigeru, Dobashi Nobuaki, Tomita Akihiro, Harada Hironori, Handa Hiroshi, Horiike Shigeo, Maeda Tomoya, Matsuda Mitsuhiro, Ichikawa Motoshi, Hata Tomoko, Honda Sumihisa, Iyama Satoshi, Suzushima Hitoshi, Moriuchi Yukiyoshi, Kurokawa Toshiro, Yokota Kenichi, Ohtake Shigeki, Yamauchi Takahiro, Matsumura Itaru, Kiyoi Hitoshi, Naoe Tomoki

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 116 ( 2 ) page： 228 - 238   2022.8

VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation Reviewed International journal

Okamoto Shuichi, Tamura Shogo, Sanda Naomi, Odaira Koya, Hayakawa Yuri, Mukaide Masato, Suzuki Atsuo, Kanematsu Takeshi, Hayakawa Fumihiko, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi, Suzuki Nobuaki

JOURNAL OF THROMBOSIS AND HAEMOSTASIS   Vol. 20 ( 8 ) page： 1784 - 1796   2022.8

Real-world treatment patterns and clinical outcomes in patients with AML in Japan who were ineligible for first-line intensive chemotherapy Reviewed International coauthorship International journal

Yoshida Chikashi, Kondo Takeshi, Ito Tomoki, Kizaki Masahiro, Yamamoto Kazuhiko, Miyamoto Toshihiro, Morita Yasuyoshi, Eto Tetsuya, Katsuoka Yuna, Takezako Naoki, Uoshima Nobuhiko, Imada Kazunori, Ando Jun, Komeno Takuya, Mori Akio, Ishikawa Yuichi, Satake Atsushi, Watanabe Junichi, Kawakami Yoshiko, Morita Tetsuo, Taneike Ikue, Nakayama Masahiko, Duan Yinghui, Garbayo Guijarro Belen, Delgado Alexander, Llamas Cynthia, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 116 ( 1 ) page： 89 - 101   2022.7

Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases Reviewed International coauthorship International journal

Dai Yu-Ting, Zhang Fan, Fang Hai, Li Jian-Feng, Lu Gang, Jiang Lu, Chen Bing, Mao Dong-Dong, Liu Yuan-Fang, Wang Jin, Peng Li-Jun, Feng Chong, Chen Hai-Feng, Mu Jun-Xi, Zhang Qun-Ling, Wang Hao, Ariffin Hany, Moy Tan Ah, Wang Jing-Han, Lou Yin-Jun, Chen Su-Ning, Wang Qian, Liu Hong, Shan Zhe, Matsumura Itaru, Miyazaki Yasushi, Yasuda Takahiko, Dou Li-Ping, Yan Xiao-jing, Yan Jin-Song, Yeoh Allen Eng-Juh, Wu De-Pei, Kiyoi Hitoshi, Hayakawa Fumihiko, Jin Jie, Wang Sheng-Yue, Sun Xiao-Jian, Mi Jian-Qing, Chen Zhu, Huang Jin-Yan, Chen Sai-Juan

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 119 ( 15 ) page： e2120787119   2022.4

Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations Reviewed International journal

Yasuda Takahiko, Sanada Masashi, Kawazu Masahito, Kojima Shinya, Tsuzuki Shinobu, Ueno Hiroo, Iwamoto Eisuke, Iijima-Yamashita Yuka, Yamada Tomomi, Kanamori Takashi, Nishimura Rieko, Kuwatsuka Yachiyo, Takada Satoru, Tanaka Masatsugu, Ota Shuichi, Dobashi Nobuaki, Yamazaki Etsuko, Hirose Asao, Murayama Tohru, Sumi Masahiko, Sato Shinya, Tange Naoyuki, Nakamura Yukinori, Katsuoka Yuna, Sakaida Emiko, Kawamata Toyotaka, Iida Hiroatsu, Shiraishi Yuichi, Nannya Yasuhito, Ogawa Seishi, Taniwaki Masafumi, Asou Norio, Hatta Yoshihiro, Kiyoi Hitoshi, Matsumura Itaru, Horibe Keizo, Mano Hiroyuki, Naoe Tomoki, Miyazaki Yasushi, Hayakawa Fumihiko

BLOOD   Vol. 139 ( 12 ) page： 1850 - 1862   2022.3

Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline Reviewed International journal

Iwama Shintaro, Kobayashi Tomoko, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Ando Masahiko, Zhou Xin, Yamagami Ayana, Onoue Takeshi, Kawaguchi Yohei, Miyata Takashi, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Wakahara Keiko, Yokota Kenji, Kato Masashi, Nishio Naoki, Tanaka Chie, Miyata Kazushi, Ogura Atsushi, Ito Takanori, Sawada Tsunaki, Shimokata Tomoya, Niimi Kaoru, Ohka Fumiharu, Ishigami Masatoshi, Gotoh Momokazu, Hashimoto Naozumi, Saito Ryuta, Kiyoi Hitoshi, Kajiyama Hiroaki, Ando Yuichi, Hibi Hideharu, Sone Michihiko, Akiyama Masashi, Kodera Yasuhiro, Arima Hiroshi

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   Vol. 107 ( 4 ) page： E1620 - E1630   2022.3

Downregulation of HLA class II is associated with relapse after allogeneic stem cell transplantation and alters recognition by antigen-specific T cells Reviewed International journal

Adachi Yoshitaka, Sakai Toshiyasu, Terakura Seitaro, Shiina Takashi, Suzuki Shingo, Hamana Hiroshi, Kishi Hiroyuki, Sasazuki Takehiko, Arase Hisashi, Hanajiri Ryo, Goto Tatsunori, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 115 ( 3 ) page： 371 - 381   2022.3

Decision Analysis for Unrelated Bone Marrow Transplantation or Immediate Cord Blood Transplantation for Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Remission Reviewed International journal

Kako Shinichi, Hayakawa Fumihiko, Miyamura Koichi, Tanaka Junji, Imai Kiyotoshi, Kanda Junya, Morishima Satoko, Uchida Naoyuki, Doki Noriko, Ikegame Kazuhiro, Ozawa Yukiyasu, Takada Satoru, Usui Noriko, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Ichinohe Tatsuo, Fukuda Takahiro, Atsuta Yoshiko, Kanda Yoshinobu

TRANSPLANTATION AND CELLULAR THERAPY   Vol. 28 ( 3 ) page： 161.e1 - 161.e10   2022.3

Immune effects of TKI altered immune responses after stopping TKI treatment and affected treatment-free remission rate Reviewed International journal

Fujioka Yuki, Takahashi Naoto, Atsuta Yoshiko, Minami Yosuke, Kiyoi Hitoshi, Miyazaki Yasushi, Matsumura Itaru

CANCER SCIENCE   Vol. 113   page： 1712 - 1712   2022.2

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia Reviewed International journal

Tsuzuki Shinobu, Yasuda Takahiko, Kawazu Masahito, Ueno Toshihide, Karnan Sivasundaram, Ota Akinobu, Sanada Masashi, Nagai Hirokazu, Tomita Akihiro, Takahashi Yoshiyuki, Miyazaki Yasushi, Matsumura Itaru, Kiyoi Hitoshi, Hosokawa Yoshitaka, Mano Hiroyuki, Hayakawa Fumihiko

CANCER SCIENCE   Vol. 113   page： 1236 - 1236   2022.2

Regulatory T Cell as a Biomarker of Treatment-Free Remission in Patients with Chronic Myeloid Leukemia Reviewed International journal

Fujioka Yuki, Sugiyama Daisuke, Matsumura Itaru, Minami Yosuke, Miura Masatomo, Atsuta Yoshiko, Ohtake Shigeki, Kiyoi Hitoshi, Miyazaki Yasushi, Nishikawa Hiroyoshi, Takahashi Naoto

CANCERS   Vol. 13 ( 23 )   2021.12

Optimal treatment for Philadelphia-negative acute lymphoblastic leukemia in first remission in the era of high-intensity chemotherapy Reviewed International journal

Kako Shinichi, Hayakawa Fumihiko, Imai Kiyotoshi, Tanaka Junji, Mizuta Shuichi, Nishiwaki Satoshi, Kanamori Heiwa, Mukae Junichi, Ozawa Yukiyasu, Kondo Tadakazu, Fukuda Takahiro, Ichinohe Tatsuo, Ota Shuichi, Tanaka Yoshinori, Murayama Tohru, Kurahashi Shingo, Sakura Toru, Usui Noriko, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Atsuta Yoshiko

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 114 ( 5 ) page： 608 - 619   2021.11

Current progress and future perspectives of research on intravascular large B-cell lymphoma Invited Reviewed International journal

Shimada Kazuyuki, Kiyoi Hitoshi

CANCER SCIENCE   Vol. 112 ( 10 ) page： 3953 - 3961   2021.10

Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival Reviewed International journal

Julamanee Jakrawadee, Terakura Seitaro, Umemura Koji, Adachi Yoshitaka, Miyao Kotaro, Okuno Shingo, Takagi Erina, Sakai Toshiyasu, Koyama Daisuke, Goto Tatsunori, Hanajiri Ryo, Hudecek Michael, Steinberger Peter, Leitner Judith, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

MOLECULAR THERAPY   Vol. 29 ( 9 ) page： 2677 - 2690   2021.9

Efficacy and safety of blinatumomab: Post hoc pooled analysis in Asian adults with relapsed/refractory B-cell precursor acute lymphoblastic leukemia Reviewed International coauthorship International journal

Kobayashi Yukio, Oh Iekuni, Miyamoto Toshihiro, Lee Won-Sik, Iida Hiroatsu, Minami Hironobu, Maeda Yoshinobu, Jang Jun Ho, Yoon Sung-Soo, Yeh Su-Peng, Tran Qui, Morris Joan, Franklin Janet, Kiyoi Hitoshi

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY     2021.6

Spacer Length Modification Facilitates Discrimination between Normal and Neoplastic Cells and Provides Clinically Relevant CD37 CAR T Cells Reviewed International journal

Okuno Shingo, Adachi Yoshitaka, Terakura Seitaro, Julamanee Jakrawadee, Sakai Toshiyasu, Umemura Koji, Miyao Kotaro, Goto Tatsunori, Murase Atsushi, Shimada Kazuyuki, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

JOURNAL OF IMMUNOLOGY   Vol. 206 ( 12 ) page： 2862 - 2874   2021.6

Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma Reviewed International journal

Kunou Shunsuke, Shimada Kazuyuki, Takai Mika, Sakamoto Akihiko, Aoki Tomohiro, Hikita Tomoya, Kagaya Yusuke, Iwamoto Eisuke, Sanada Masashi, Shimada Satoko, Hayakawa Fumihiko, Oneyama Chitose, Kiyoi Hitoshi

ONCOGENE   Vol. 40 ( 23 ) page： 3989 - 4003   2021.6

Phase I clinical trial of intra-bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation Reviewed International journal

Goto Tatsunori, Murata Makoto, Nishida Tetsuya, Terakura Seitaro, Kamoshita Sonoko, Ishikawa Yuichi, Ushijima Yoko, Adachi Yoshiya, Suzuki Satoshi, Kato Katsuyoshi, Hirakawa Akihiro, Nishiwaki Satoshi, Nishio Nobuhiro, Takahashi Yoshiyuki, Kodera Yoshihisa, Matsushita Tadashi, Kiyoi Hitoshi

STEM CELLS TRANSLATIONAL MEDICINE   Vol. 10 ( 4 ) page： 542 - 553   2021.4

Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group Reviewed International journal

Saito Takeshi, Hatta Yoshihiro, Hayakawa Fumihiko, Takahashi Tsutomu, Hagihara Maki, Iida Hiroatsu, Minauchi Koichiro, Yamazaki Etsuko, Sugiura Isamu, Murayama Tohru, Sakura Toru, Mori Naoki, Imai Kiyotoshi, Yahagi Yuichi, Atsuta Yoshiko, Saito Akiko Moriya, Hirakawa Akihiro, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 113 ( 3 ) page： 395 - 403   2021.3

Machine learning-aided risk stratification in Philadelphia chromosome-positive acute lymphoblastic leukemia

Nishiwaki Satoshi, Sugiura Isamu, Koyama Daisuke, Ozawa Yukiyasu, Osaki Masahide, Ishikawa Yuichi, Kiyoi Hitoshi

BIOMARKER RESEARCH   Vol. 9 ( 1 ) page： 13   2021.2

Impact of variation in reagent combinations for one-stage clotting assay on assay discrepancy in nonsevere haemophilia A Reviewed International journal

Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Okamoto Shuichi, Tamura Shogo, Kikuchi Ryosuke, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY   Vol. 43 ( 1 ) page： 131 - 138   2021.2

<i>Myh9</i> R702C is associated with erythroid abnormality with splenomegaly in mice Reviewed International journal

Kanematsu, T; Suzuki, N; Tamura, S; Suzuki, A; Ishikawa, Y; Katsumi, A; Kiyoi, H; Saito, H; Kunishima, S; Kojima, T; Matsushita, T

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 1 ) page： 75 - 86   2021.2

Exosomes derived from cancer associated fibroblasts induce a resistance to histone deacetylase inhibitors in lymphoma Reviewed International journal

Kagaya Yusuke, Shimada Kazuyuki, Kunou Shunsuke, Hikita Tomoya, Sakamoto Akihiko, Hayakawa Fumihiko, Oneyama Chitose, Kiyoi Hitoshi

CANCER SCIENCE   Vol. 112   page： 370 - 370   2021.2

Research on FLT3 mutations and targeted therapeutics Invited International journal

Naoe Tomoki, Kiyoi Hitoshi, Yokota Shohei

CANCER SCIENCE   Vol. 112   page： 1016 - 1016   2021.2

A case of reexpansion pulmonary edema and acute pulmonary thromboembolism associated with diffuse large B-cell lymphoma treated with venovenous extracorporeal membrane oxygenation. Reviewed International journal

Kazama S, Hiraiwa H, Kimura Y, Ozaki R, Shibata N, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Kondo T, Furusawa K, Morimoto R, Okumura T, Bando YK, Sato T, Shimada K, Kiyoi H, Nakamura G, Yasuda Y, Kasugai D, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Goto Y, Matsuda N, Murohara T

Journal of cardiology cases   Vol. 23 ( 1 ) page： 53 - 56   2021.1

Bursitis, Bacteremia, and Disseminated Infection of Mycobacteroides (Mycobacterium) abscessus subsp. massiliense Reviewed International journal

Oka Keisuke, Morioka Hiroshi, Eguchi Motoki, Sato Yoshitaka, Tetsuka Nobuyuki, Iguchi Mitsutaka, Kanematsu Takeshi, Fukano Hanako, Hoshino Yoshihiko, Kiyoi Hitoshi, Yagi Tetsuya

INTERNAL MEDICINE   Vol. 60 ( 18 ) page： 3041 - 3045   2021

Predictors of early death, serious hemorrhage, and differentiation syndrome in Japanese patients with acute promyelocytic leukemia Reviewed International journal

Minamiguchi Hitoshi, Fujita Hiroyuki, Atsuta Yoshiko, Asou Norio, Sakura Toru, Ueda Yasunori, Sawa Masashi, Dobashi Nobuaki, Taniguchi Yasuhiro, Suzuki Rikio, Uchino Yoshihito, Tomita Akihiro, Tamaki Shigehisa, Hagihara Maki, Fujimaki Katsumichi, Yanada Masamitsu, Maeda Yoshinobu, Iwanaga Masako, Usui Noriko, Kobayashi Yukio, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Takeshita Akihiro

ANNALS OF HEMATOLOGY   Vol. 99 ( 12 ) page： 2787 - 2800   2020.12

Multi-Lineage BCR-ABL Expression in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Is Associated With Improved Prognosis but No Specific Molecular Features Reviewed International journal

Nishiwaki Satoshi, Kim Jeong Hui, Ito Masafumi, Maeda Matsuyoshi, Okuno Yusuke, Koyama Daisuke, Ozawa Yukiyasu, Gunji Masaharu, Osaki Masahide, Kitamura Kunio, Ushijima Yoko, Ishikawa Yuichi, Miyamura Koichi, Sugiura Isamu, Kiyoi Hitoshi

FRONTIERS IN ONCOLOGY   Vol. 10   page： 586567   2020.10

Phase I study of duvelisib in Japanese patients with relapsed or refractory lymphoma Reviewed International journal

Izutsu Koji, Kato Koji, Kiyoi Hitoshi, Yamamoto Go, Shimada Kazuyuki, Akashi Koichi

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 112 ( 4 ) page： 504 - 509   2020.10

Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity Reviewed International journal

Sakai Toshiyasu, Terakura Seitaro, Miyao Kotaro, Okuno Shingo, Adachi Yoshitaka, Umemura Koji, Julamanee Jakrawadee, Watanabe Keisuke, Hamana Hiroshi, Kishi Hiroyuki, Leitner Judith, Steinberger Peter, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

MOLECULAR THERAPY-ONCOLYTICS   Vol. 18   page： 613 - 622   2020.9

Real-world management of infection during chemotherapy for acute leukemia in Japan: from the results of a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group Reviewed International journal

Kimura Shun-ichi, Fujita Hanako, Handa Hiroshi, Hiramoto Nobuhiro, Hosono Naoko, Minamiguchi Hitoshi, Takahashi Tsutomu, Kato Hideaki, Ono Takaaki, Kanda Yoshinobu, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 112 ( 3 ) page： 409 - 417   2020.9

Clinical utility of target capture-based panel sequencing in hematological malignancies: A multicenter feasibility study Reviewed International journal

Yasuda Takahiko, Sanada Masashi, Nishijima Dai, Kanamori Takashi, Iijima Yuka, Hattori Hiroyoshi, Saito Akiko, Miyoshi Hiroaki, Ishikawa Yuichi, Asou Norio, Usuki Kensuke, Hirabayashi Shinsuke, Kato Motohiro, Ri Masaki, Handa Hiroshi, Ishida Tadao, Shibayama Hirohiko, Abe Masahiro, Iriyama Chisako, Karube Kennosuke, Nishikori Momoko, Ohshima Koichi, Kataoka Keisuke, Yoshida Kenichi, Shiraishi Yuichi, Goto Hiroaki, Adachi Souichi, Kobayashi Ryoji, Kiyoi Hitoshi, Miyazaki Yasushi, Ogawa Seishi, Kurahashi Hiroki, Yokoyama Hisayuki, Manabe Atsushi, Iida Shinsuke, Tomita Akihiro, Horibe Keizo

CANCER SCIENCE   Vol. 111 ( 9 ) page： 3367 - 3378   2020.9

Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia (vol 111, pg 1314, 2020) Reviewed International coauthorship International journal

Kiyoi Hitoshi, Morris Joan D., Oh Iekuni, Maeda Yoshinobu, Minami Hironobu, Miyamoto Toshihiro, Sakura Toru, Iida Hiroatsu, Tuglus Catherine A., Chen Yuqi, Dos Santos Cedric, Kalabus James, Anderson Abraham, Hata Tomoko, Nakashima Yasuhiro, Kobayashi Yukio

CANCER SCIENCE   Vol. 111 ( 8 ) page： 3082 - 3082   2020.8

Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells. Reviewed International journal

Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie   Vol. 128   page： 110330   2020.8

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. Reviewed International journal

Tsuzuki S, Yasuda T, Kojima S, Kawazu M, Akahane K, Inukai T, Imaizumi M, Morishita T, Miyamura K, Ueno T, Karnan S, Ota A, Hyodo T, Konishi H, Sanada M, Nagai H, Horibe K, Tomita A, Suzuki K, Muramatsu H, Takahashi Y, Miyazaki Y, Matsumura I, Kiyoi H, Hosokawa Y, Mano H, Hayakawa F

Blood cancer discovery   Vol. 1 ( 1 ) page： 82 - 95   2020.7

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia Reviewed International journal

Tsuzuki Shinobu, Yasuda Takahiko, Kojima Shinya, Kawazu Masahito, Akahane Koshi, Inukai Takeshi, Imaizumi Masue, Morishita Takanobu, Miyamura Koichi, Ueno Toshihide, Karnan Sivasundaram, Ota Akinobu, Hyodo Toshinori, Konishi Hiroyuki, Sanada Masashi, Nagai Hirokazu, Horibe Keizo, Tomita Akihiro, Suzuki Kyogo, Muramatsu Hideki, Takahashi Yoshiyuki, Miyazaki Yasushi, Matsumura Itaru, Kiyoi Hitoshi, Hosokawa Yoshitaka, Mano Hiroyuki, Hayakawa Fumihiko

BLOOD CANCER DISCOVERY   Vol. 1 ( 1 ) page： 82 - 95   2020.7

Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies Reviewed International journal

Mizuno Kazuyuki, Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Kawashima Hiroki, Inukai Yosuke, Toyoda Hidenori, Yokota Kenji, Hase Tetsunari, Maeda Osamu, Kiyoi Hitoshi, Nagino Masato, Hibi Hideharu, Kodera Yasuhiro, Fujimoto Yasushi, Sone Michihiko, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Fujishiro Mitsuhiro

JOURNAL OF GASTROENTEROLOGY   Vol. 55 ( 6 ) page： 653 - 661   2020.6

Impact of CD56 Continuously Recognizable as Prognostic Value of Acute Promyelocytic Leukemia: Results of Multivariate Analyses in the Japan Adult Leukemia Study Group (JALSG)-APL204 Study and a Review of the Literature. Reviewed International journal

Takeshita A, Asou N, Atsuta Y, Furumaki H, Sakura T, Ueda Y, Sawa M, Dobashi N, Taniguchi Y, Suzuki R, Nakagawa M, Tamaki S, Hagihara M, Fujimaki K, Minamiguchi H, Fujita H, Yanada M, Maeda Y, Usui N, Kobayashi Y, Kiyoi H, Ohtake S, Matsumura I, Naoe T, Miyazaki Y, Group TJALS

Cancers   Vol. 12 ( 6 )   2020.6

JSH Practical Guidelines for Hematological Malignancies, 2018: I. Leukemia-1. Acute myeloid leukemia (AML) Invited Reviewed International journal

Kiyoi Hitoshi, Yamaguchi Hiroki, Maeda Yoshinobu, Yamauchi Takahiro

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 111 ( 5 ) page： 595 - 613   2020.5

Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial Reviewed International journal

Shimada Kazuyuki, Yamaguchi Motoko, Atsuta Yoshiko, Matsue Kosei, Sato Keijiro, Kusumoto Shigeru, Nagai Hirokazu, Takizawa Jun, Fukuhara Noriko, Nagafuji Koji, Miyazaki Kana, Ohtsuka Eiichi, Okamoto Masataka, Sugita Yasumasa, Uchida Toshiki, Kayukawa Satoshi, Wake Atsushi, Ennishi Daisuke, Kondo Yukio, Izumi Tohru, Kin Yoshihiro, Tsukasaki Kunihiro, Hashimoto Daigo, Yuge Masaaki, Yanagisawa Atsumi, Kuwatsuka Yachiyo, Shimada Satoko, Masaki Yasufumi, Niitsu Nozomi, Kiyoi Hitoshi, Suzuki Ritsuro, Tokunaga Takashi, Nakamura Shigeo, Kinoshita Tomohiro

LANCET ONCOLOGY   Vol. 21 ( 4 ) page： 593 - 602   2020.4

Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia Reviewed International coauthorship International journal

Kiyoi Hitoshi, Morris Joan D., Oh Lekuni, Maeda Yoshinobu, Minami Hironobu, Miyamoto Toshihiro, Sakura Toru, Iida Hiroatsu, Tuglus Catherine A., Chen Yuqi, Dos Santos Cedric, Kalabus James, Anderson Abraham, Hata Tomoko, Nakashima Yasuhiro, Kobayashi Yukio

CANCER SCIENCE   Vol. 111 ( 4 ) page： 1314 - 1323   2020.4

Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy Reviewed International journal

Ogawa Mika, Suzuki Nobuaki, Takahashi Nobunori, Tamura Shogo, Suzuki Atsuo, Suzuki Sachiko, Hattori Yuua, Kakihara Misaki, Kanematsu Takeshi, Kojima Toshihisa, Katsumi Akira, Hayakawa Fumihiko, Kojima Tetsuhito, Ishiguro Naoki, Kiyoi Hitoshi, Matsushita Tadashi

THROMBOSIS RESEARCH   Vol. 188   page： 103 - 105   2020.4

Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study. Reviewed International journal

Okada N, Iwama S, Okuji T, Kobayashi T, Yasuda Y, Wada E, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Hase T, Morise M, Kanda M, Yokota K, Hashimoto N, Ando M, Fujimoto Y, Nagino M, Kodera Y, Fujishiro M, Hibi H, Sone M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H

British journal of cancer   Vol. 122 ( 6 ) page： 771 - 777   2020.3

悪性リンパ腫診療の進歩とピットフォール Invited

島田和之、清井仁

日本内科学会雑誌   Vol. 109 ( 3 ) page： 574 - 578   2020.3

<i>FLT3</i> mutations in acute myeloid leukemia: Therapeutic paradigm beyond inhibitor development Invited Reviewed International journal

Kiyoi, H; Kawashima, N; Ishikawa, Y

CANCER SCIENCE   Vol. 111 ( 2 ) page： 312 - 322   2020.2

Prospective evaluation of prognostic impact of KIT mutations on acute myeloid leukemia with RUNX1-RUNX1T1 and CBFB-MYH11 Reviewed International journal

Ishikawa Yuichi, Kawashima Naomi, Atsuta Yoshiko, Sugiura Isamu, Sawa Masashi, Dobashi Nobuaki, Yokoyama Hisayuki, Doki Noriko, Tomita Akihiro, Kiguchi Toru, Koh Shiro, Kanamori Heiwa, Iriyama Noriyoshi, Kohno Akio, Moriuchi Yukiyoshi, Asada Noboru, Hirano Daiki, Togitani Kazuto, Sakura Toru, Hagihara Maki, Tomikawa Tatsuki, Yokoyama Yasuhisa, Asou Norio, Ohtake Shigeki, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Kiyoi Hitoshi

BLOOD ADVANCES   Vol. 4 ( 1 ) page： 66 - 75   2020.1

Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation. Reviewed International journal

Kamoshita S, Murata M, Koyama D, Julamanee J, Okuno S, Takagi E, Miyao K, Goto T, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H

International journal of hematology   Vol. 111 ( 1 ) page： 112 - 119   2020.1

Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia Reviewed International journal

Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

INTERNAL MEDICINE   Vol. 59 ( 5 ) page： 683 - 687   2020

Allogeneic Hematopoietic Stem Cell Transplantation for Post-essential Thrombocythemia and Post-polycythemia Vera Myelofibrosis Reviewed International journal

Murata, M; Suzuki, R; Nishida, T; Shirane, S; Shimazu, Y; Minami, Y; Mori, T; Doki, N; Kanda, Y; Uchida, N; Tanaka, M; Ishikawa, J; Togitani, K; Fukuda, T; Ichinohe, T; Atsuta, Y; Nagamura-Inoue, T; Kiyoi, H

INTERNAL MEDICINE   Vol. 59 ( 16 ) page： 1947 - 1956   2020

Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors.

Okamoto S, Suzuki N, Suzuki A, Suzuki S, Tamura S, Suzuki M, Takahashi N, Kojima T, Kanematsu T, Kojima T, Kiyoi H, Ishiguro N, Matsushita T

TH open : companion journal to thrombosis and haemostasis   Vol. 3 ( 4 ) page： e364-e366   2019.10

ZNF384-fusion proteins have high affinity for the transcriptional coactivator EP300 and aberrant transcriptional activities. Reviewed International journal

Yamamoto H, Hayakawa F, Yasuda T, Odaira K, Minamikawa Y, Tange N, Hirano D, Kojima Y, Morishita T, Tsuzuki S, Naoe T, Kiyoi H

FEBS letters   Vol. 593 ( 16 ) page： 2151 - 2161   2019.8

Exome analysis of treatment-related AML after APL suggests secondary evolution. Reviewed International coauthorship International journal

Wang T, Jacoby MA, Duncavage EJ, Miller CA, Heath S, Rahme R, Fenaux P, Ades L, Renneville A, Cassinat B, Takeshita A, Asou N, Miyazaki Y, Kiyoi H, Ravandi F, Westervelt P, Wartman LD, Welch JS

British journal of haematology   Vol. 185 ( 5 ) page： 984 - 987   2019.6

Efficacy and safety of tyrosine kinase inhibitors for newly diagnosed chronic-phase chronic myeloid leukemia over a 5-year period: results from the Japanese registry obtained by the New TARGET system Invited Reviewed International journal

Kizaki Masahiro, Takahashi Naoto, Iriyama Noriyoshi, Okamoto Shinichiro, Ono Takaaki, Usui Noriko, Inokuchi Koiti, Nakaseko Chiaki, Kurokawa Mineo, Sumi Masahiko, Nakamura Fumihiko, Kawaguchi Tatsuya, Suzuki Ritsuro, Yamamoto Kazuhito, Ohnishi Kazunori, Matsumura Itaru, Naoe Tomoki, Kizaki M., Mori S., Nemoto T., Sagawa M., Tabayashi T., Tokuhira M., Tomikawa T., Watanabe R., Hatta Y., Inoue Y., Iriyama N., Kobayashi S., Kobayashi Y., Kurita D., Karigane D., Kasahara H., Koda Y., Miyakawa Y., Murakami K., Okamoto S., Watanuki S., Ono T., Nagata Y., Takeshita A., Takahashi N., Kameoka Y., Yoshioka T., Takahashi S., Usui N., Dan K., Inokuchi K., Nakamura K., Abe D., Nakaseko C., Ohwada C., Sakaida E., Shimizu N., Takeuchi M., Arai S., Kogure Y., Koya A., Masamoto Y., Masuda A., Nakazaki K., Toyama K., Hiroshima Y., Ichikawa N., Kirihara T., Kobayashi H., Shimizu I., Sumi M., Ueki T., Hagiwara S., Hirai R., Miwa T., Nakamura F., Nakamura M., Takeshita M., Tanimura A., Hayakawa F., Ishikawa Y., Kiyoi H., Murata M., Tomita A., Kurokawa T., Sugimori C., Arai A., Miura O., Yamamoto M., Imai K., Kobayashi N., Minauchi K., Obara M., Ota S., Ikezoe T., Mori M., Sakai M., Taniguchi A., Togitani K., Hayakawa H., Kajiguchi T., Kamoshita S., Otsuka E., Nishida A., Saburi M., Saburi Y., Iida H., Kato C., Kojima Y., Ohashi H., Miyata Y., Sugimoto K., Yamamoto H., Yokozawa T., Kamae T., Kuyama J., Mitsui H., Morikawa Y., Uchida Y., Ashida T., Hirase C., Kawanishi K., Matsumura I., Miyatake J., Morita Y., Sano T., Shimada T., Tanaka H., Taniguchi Y., Tatsumi Y., Yamaguchi K., Ishida F., Momose K., Nakazawa H., Nishina S., Sakai H., Sekiguchi N., Ito Y., Ohyashiki K., Tauchi T., Hata T., Imaizumi Y., Imanishi D., Itonaga H., Makiyama J., Sawayama Y., Taguchi J., Taguchi M., Taniguchi H., Eguchi G., Matsuda M., Yamairi N., Fukushima N., Ozeki K., Kohno A., Sakura T., Takada S., Kobayashi T., Sakamaki H., Asou N., Kawaguchi T., Kiguchi T., Masunari T., Sezaki N., Iino M., Morinaga K., Ikeda K., Ogawa K., Noji H., Iwasaki H., Takenaka K., Miyamoto T., Handa H., Murakami H., Tsukamoto N., Eto T., Henzan H., Kamitsuji Y., Uoshima N., Hagihara M., Takahashi H., Emi N., Okamoto M., Kawakami K., Waki M., Fukuhara N., Harigae H., Murayama T., Mizuno I., Okumura H., Tsutsumi Y., Usuki K., Fujisaki T., Maeda Y., Suehiro Y., Suzushima H., Yamamoto K., Kanakura Y., Nagasaki K., Muto H., Fujisawa S., Mugitani A., Yamasaki S., Adachi Y., Kamimura T., Takamatsu Y., Ryu T., Chiba S., Ohishi K., Suzuki K., Ogawa D., Mihara H., Fujita H., Kubo K., Yokota A., Yoshida C., Nakachi S., Myojyo T., Kitabayashi A., Suzumiya J., Hino M., Wakita A., Shibata T., Takahashi T., Takamatsu H., Fujimaki K., Tajika K., Mita M., Terui Y., Ito M., Yamane T., Yamamoto K., Yamauchi T., Kohara Y., Takebayashi C., Inagaki A., Tsuji M., Shinzaki H., Moriuchi Y., Ishikawa M., Miyazaki K., Shima E., Kinugawa N.

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 109 ( 4 ) page： 426 - 439   2019.4

Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity. Reviewed International journal

Hirano D, Hayakawa F, Yasuda T, Tange N, Yamamoto H, Kojima Y, Morishita T, Imoto N, Tsuzuki S, Mano H, Naoe T, Kiyoi H

Oncogene   Vol. 38 ( 13 ) page： 2263 - 2274   2019.3

Defective Epstein-Barr virus in chronic active infection and haematological malignancy. Reviewed International journal

Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H

Nat Microbiol.   Vol. 4 ( 3 ) page： 404 - 413   2019.3

Quantitative Assessment of T Cell Clonotypes in Human Acute Graft-versus-Host Disease Tissues. Reviewed International journal

Koyama D, Murata M, Hanajiri R, Akashi T, Okuno S, Kamoshita S, Julamanee J, Takagi E, Miyao K, Sakemura R, Goto T, Terakura S, Nishida T, Kiyoi H

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   Vol. 25 ( 3 ) page： 417 - 423   2019.3

Publisher Correction: Defective Epstein-Barr virus in chronic active infection and haematological malignancy. Reviewed International journal

Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H

Nature microbiology   Vol. 4 ( 3 ) page： 544   2019.3

Tamibarotene maintenance improved relapse-free survival of acute promyelocytic leukemia: a final result of prospective, randomized, JALSG-APL204 study. Reviewed International journal

Takeshita A, Asou N, Atsuta Y, Sakura T, Ueda Y, Sawa M, Dobashi N, Taniguchi Y, Suzuki R, Nakagawa M, Tamaki S, Hagihara M, Fujimaki K, Furumaki H, Obata Y, Fujita H, Yanada M, Maeda Y, Usui N, Kobayashi Y, Kiyoi H, Ohtake S, Matsumura I, Naoe T, Miyazaki Y, and the Japanese Adult Leukemia Study Group.

Leukemia   Vol. 33 ( 2 ) page： 358 - 370   2019.2

Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study. Reviewed International journal

Kawashima N, Akashi A, Nagata Y, Kihara R, Ishikawa Y, Asou N, Ohtake S, Miyawaki S, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kitamura K, Sakaida E, Takeshita A, Suzushima H, Naoe T, Matsumura I, Miyazaki Y, Ogawa S, Kiyoi H, Japan Adult Leukemia Study Group (JALSG).

Annals of hematology   Vol. 98 ( 1 ) page： 83 - 91   2019.1

[Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient]. Reviewed

Harada Y, Murata M, Matsumoto A, Kato D, Yagi T, Yaguchi T, Yoshikawa T, Takeichi T, Akiyama M, Yamaguchi Y, Koyama D, Terakura S, Nishida T, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 60 ( 12 ) page： 1641 - 1646   2019

[Acute myeloid leukemia: AML]. Invited

Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 60 ( 3 ) page： 224 - 225   2019

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Reviewed

Proceedings of the National Academy of Sciences of the United States of America     2018.11

Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells. Reviewed

Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H

Cancer science     2018.11

Prognostic Analysis According to the 2017 ELN Risk Stratification by Genetics in Adult Acute Myeloid Leukemia Patients Treated in The Japan Adult Leukemia Study Group (JALSG) AML201 study Reviewed

Harada Yasuhiko, Nagata Yasunobu, Kihara Rika, Ishikawa Yuichi, Asou Norio, Ohtake Shigeki, Miyawaki Shuichi, Sakura Toru, Ozawa Yukiyasu, Usui Noriko, Kanamori Heiwa, Ito Yoshikazu, Imai Kiyotoshi, Suehiro Youko, Kobayashi Shinichi, Kitamura Kunio, Sakaida Emiko, Onizuka Makoto, Takeshita Akihiro, Ishida Fumihiro, Suzushima Hitoshi, Ishizawa Kenichi, Naoe Tomoki, Matsumura Itaru, Miyazaki Yasushi, Ogawa Seishi, Kiyoi Hitoshi

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   Vol. 18   page： S196-S196   2018.9

Impact of hospital length of stay on the risk of readmission and overall survival after allogeneic stem cell transplantation Reviewed International journal

Seto Aika, Atsuta Yoshiko, Kawashima Naomi, Ozawa Yukiyasu, Miyamura Koichi, Kiyoi Hitoshi

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 108 ( 3 ) page： 290 - 297   2018.9

Final analysis of the JALSG Ph+ALL202 study: tyrosine kinase inhibitor-combined chemotherapy for Ph plus ALL Reviewed International journal

Hatta Yoshihiro, Mizuta Shuichi, Matsuo Keitaro, Ohtake Shigeki, Iwanaga Masako, Sugiura Isamu, Doki Noriko, Kanamori Heiwa, Ueda Yasunori, Yoshida Chikamasa, Dobashi Nobuaki, Maeda Tomoya, Yujiri Toshiaki, Monma Fumihiko, Ito Yoshikazu, Hayakawa Fumihiko, Takeuchi Jin, Kiyoi Hitoshi, Miyazaki Yasushi, Naoe Tomoki

ANNALS OF HEMATOLOGY   Vol. 97 ( 9 ) page： 1535 - 1545   2018.9

Biology and management of primary effusion lymphoma. Reviewed

Shimada K, Hayakawa F, Kiyoi H

Blood     2018.8

Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response Reviewed International journal

Ueda Norihiro, Uemura Yasushi, Zhang Rong, Kitayama Shuichi, Iriguchi Shoichi, Kawai Yohei, Yasui Yutaka, Tatsumi Minako, Ueda Tatsuki, Liu Tian-Yi, Mizoro Yasutaka, Okada Chihiro, Watanabe Akira, Nakanishi Mahito, Senju Satoru, Nishimura Yasuharu, Kuzushima Kiyotaka, Kiyoi Hitoshi, Naoe Tomoki, Kaneko Shin

STEM CELL REPORTS   Vol. 10 ( 6 ) page： 1935 - 1946   2018.6

Infectious complications in adults undergoing intensive chemotherapy for acute myeloid leukemia in 2001-2005 using the Japan Adult Leukemia Study Group AML201 protocols.

Kato H, Fujita H, Akiyama N, Kimura SI, Hiramoto N, Hosono N, Takahashi T, Shigeno K, Minamiguchi H, Miyatake J, Handa H, Kanda Y, Yoshida M, Miyawaki S, Ohtake S, Naoe T, Kiyoi H, Matsumura I, Miyazaki Y, Japan Adult Leukemia Study Group.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     2018.6

Introduction of Genetically Modified CD3 zeta Improves Proliferation and Persistence of Antigen-Specific CTLs Reviewed International journal

Miyao Kotaro, Terakura Seitaro, Okuno Shingo, Julamanee Jakrawadee, Watanabe Keisuke, Hamana Hiroshi, Kishi Hiroyuki, Sakemura Reona, Koyama Daisuke, Goto Tatsunori, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

CANCER IMMUNOLOGY RESEARCH   Vol. 6 ( 6 ) page： 733 - 744   2018.6

Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia. Reviewed

Tanaka Y, Kawazu M, Yasuda T, Tamura M, Hayakawa F, Kojima S, Ueno T, Kiyoi H, Naoe T, Mano H

Haematologica     2018.5

Mutation analysis of therapy-related myeloid neoplasms Reviewed International journal

Nishiyama Takahiro, Ishikawa Yuichi, Kawashima Naomi, Akashi Akimi, Adachi Yoshiya, Hattori Hikaru, Ushijima Yoko, Kiyoi Hitoshi

CANCER GENETICS   Vol. 222   page： 38 - 45   2018.4

Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol Reviewed International journal

Goto Tatsunori, Murata Makoto, Terakura Seitaro, Nishida Tetsuya, Adachi Yoshiya, Ushijima Yoko, Shimada Kazuyuki, Ishikawa Yuichi, Hayakawa Fumihiko, Nishio Nobuhiro, Nishiwaki Satoshi, Hirakawa Akihiro, Kato Katsuyoshi, Takahashi Yoshiyuki, Kiyoi Hitoshi

MEDICINE   Vol. 97 ( 17 ) page： e0449   2018.4

Analysis of the oligomeric states of nucleophosmin using size exclusion chromatography Reviewed International journal

Sakashita Gyosuke, Kiyoi Hitoshi, Naoe Tomoki, Urano Takeshi

SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page： 4008   2018.3

Clinical impact of underweight status at diagnosis on elderly patients with acute myeloid leukemia: a retrospective study of JALSG GML200. Reviewed

Harada K, Doki N, Miyazaki Y, Wakita A, Ohtake S, Takada S, Komatsu H, Kubo K, Takeshita A, Adachi Y, Kiyoi H, Yamaguchi T, Yoshida M, Naoe T, Ohashi K

Annals of hematology     2018.3

High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG. Reviewed International journal

Sakura T, Hayakawa F, Sugiura I, Murayama T, Imai K, Usui N, Fujisawa S, Yamauchi T, Yujiri T, Kakihana K, Ito Y, Kanamori H, Ueda Y, Miyata Y, Kurokawa M, Asou N, Ohnishi K, Ohtake S, Kobayashi Y, Matsuo K, Kiyoi H, Miyazaki Y, Naoe T.

Leukemia   Vol. 32 ( 3 ) page： 626 - 632   2018.3

Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study. Reviewed

Harada Y, Nagata Y, Kihara R, Ishikawa Y, Asou N, Ohtake S, Miyawaki S, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Onizuka M, Takeshita A, Ishida F, Suzushima H, Ishizawa K, Naoe T, Matsumura I, Miyazaki Y, Ogawa S, Kiyoi H, Japan Adult Leukemia Study Group JALSG.

Leukemia research   Vol. 66   page： 20-27   2018.3

High Incidence of Extensive Chronic Gvhd in Patients with the REG3A Rs7588571 Non-GG Genotype Reviewed

Murata Makoto, Koyama Daisuke, Hanajiri Ryo, Okuno Shingo, Kamoshita Sonoko, Julamanee Jakrawadee, Takagi Erina, Hirano Daiki, Miyao Kotaro, Sakemura Reona, Goto Tatsunori, Hayakawa Fumihiko, Seto Aika, Ozawa Yukiyasu, Miyamura Koichi, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   Vol. 24 ( 3 ) page： S192-S193   2018.3

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study Reviewed International journal

Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

JOURNAL OF THE ENDOCRINE SOCIETY   Vol. 2 ( 3 ) page： 241 - 251   2018.3

Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia. Reviewed

Kamijo R, Itonaga H, Kihara R, Nagata Y, Hata T, Asou N, Ohtake S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Naoe T, Kiyoi H, Miyazaki Y

Leukemia research   Vol. 65   page： 34-41   2018.2

Intrabone single unit cord blood transplantation for hematological malignancies Reviewed

Murata Makoto, Maeda Yoshinobu, Masuko Masayoshi, Fukuhara Noriko, Nishida Tetsuya, Terakura Seitaro, Ishikawa Yuichi, Tanimoto Mitsune, Shibasaki Yasuhiko, Suzuki Ritsuro, Kodera Yoshihisa, Kiyoi Hitoshi, Naoe Tomoki

CANCER SCIENCE   Vol. 109   page： 757-757   2018.1

BCR-ABL-specific CD4⁺ T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells. Reviewed International journal

Ueda N, Zhang R, Tatsumi M, Liu TY, Kitayama S, Yasui Y, Sugai S, Iwama T, Senju S, Okada S, Nakatsura T, Kuzushima K, Kiyoi H, Naoe T, Kaneko S, Uemura Y

Cellular & molecular immunology   Vol. 15 ( 1 ) page： 15 - 26   2018.1

Underweight status at diagnosis is associated with poorer outcomes in adult patients with acute myeloid leukemia: a retrospective study of JALSG AML 201 Reviewed International journal

Harada Kaito, Doki Noriko, Hagino Takeshi, Miyawaki Shuichi, Ohtake Shigeki, Kiyoi Hitoshi, Miyazaki Yasushi, Fujita Hiroyuki, Usui Noriko, Okumura Hirokazu, Miyamura Koichi, Nakaseko Chiaki, Fujieda Atsushi, Nagai Tadashi, Yamane Takahisa, Sakamaki Hisashi, Ohnishi Kazunori, Naoe Tomoki, Ohno Ryuzo, Ohashi Kazuteru

ANNALS OF HEMATOLOGY   Vol. 97 ( 1 ) page： 73 - 81   2018.1

Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia. Reviewed

Hattori H, Ishikawa Y, Kawashima N, Akashi A, Yamaguchi Y, Harada Y, Hirano D, Adachi Y, Miyao K, Ushijima Y, Terakura S, Nishida T, Matsushita T, Kiyoi H

PloS one   Vol. 13 ( 10 ) page： e0204850   2018

Underweight status at diagnosis is associated with poorer outcomes in adult patients with acute myeloid leukemia: a retrospective study of JALSG AML 201. Reviewed

Harada K, Doki N, Hagino T, Miyawaki S, Ohtake S, Kiyoi H, Miyazaki Y, Fujita H, Usui N, Okumura H, Miyamura K, Nakaseko C, Fujieda A, Nagai T, Yamane T, Sakamaki H, Ohnishi K, Naoe T, Ohno R, Ohashi K

Ann Hematol.     2017.12

Efficacy and safety of autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia: A study protocol for a multicenter exploratory prospective study (Auto-Ph17 study) Reviewed International journal

Nishiwaki Satoshi, Sugiura Isamu, Miyata Yasuhiko, Saito Shigeki, Sawa Masashi, Nishida Tetsuya, Miyamura Koichi, Kuwatsuka Yachiyo, Kohno Akio, Yuge Masaaki, Kasai Masanobu, Iida Hiroatsu, Kurahashi Shingo, Osaki Masahide, Goto Tatsunori, Terakura Seitaro, Murata Makoto, Nishikawa Hiroyoshi, Kiyoi Hitoshi

MEDICINE   Vol. 96 ( 52 ) page： e9568   2017.12

Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome. Reviewed

Shirahata-Adachi M, Iriyama C, Tomita A, Suzuki Y, Shimada K, Kiyoi H.

Leuk Res   Vol. 63   page： 90-97   2017.11

Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia. Reviewed

Kuwatsuka Y, Tomizawa D, Kihara R, Nagata Y, Shiba N, Iijima-Yamashita Y, Shimada A, Deguchi T, Miyachi H, Tawa A, Taga T, Kinoshita A, Nakayama H, Kiyokawa N, Saito AM, Koh K, Goto H, Kosaka Y, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Ogawa S, Naoe T, Hayashi Y, Horibe K, Manabe A, Mizutani S, Adachi S, Kiyoi H.

Int J Hematol     2017.10

Identification of volasertib-resistant mechanism and evaluation of combination effects with volasertib and other agents on acute myeloid leukemia. Reviewed

Adachi Y, Ishikawa Y, Kiyoi H.

Oncotarget   Vol. 8   page： 78452-78465   2017.10

A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study). Reviewed

Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Hanaoka N, Nakakuma H, Hasegawa D, Manabe A, Fujishima N, Fujii N, Tanimoto M, Morita Y, Matsuda A, Fujieda A, Katayama N, Ohashi H, Nagai H, Terada Y, Hino M, Sato K, Obara N, Chiba S, Usuki K, Ohta M, Imataki O, Uemura M, Takaku T, Komatsu N, Kitanaka A, Shimoda K, Watanabe K, Tohyama K, Takaori-Kondo A, Harigae H, Arai S, Miyazaki Y, Ozawa K, Kurokawa M; for National Research Group on Idiopathic Bone Marrow Failure Syndromes.

Am J Hematol   Vol. 92   page： 1324-1332   2017.9

High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype.

Koyama D, Murata M, Hanajiri R, Okuno S, Kamoshita S, Julamanee J, Takagi E, Hirano D, Miyao K, Sakemura R, Goto T, Hayakawa F, Seto A, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H.

PLoS One12     page： e0185213   2017.9

Deeper molecular response is a predictive factor for treatment-free remission after imatinib discontinuation in patients with chronic phase chronic myeloid leukemia: the JALSG-STIM213 study. Reviewed

Takahashi N, Tauchi T, Kitamura K, Miyamura K, Saburi Y, Hatta Y, Miyata Y, Kobayashi S, Usuki K, Matsumura I, Minami Y, Usui N, Fukuda T, Takada S, Ishikawa M, Fujimaki K, Gomyo H, Sasaki O, Ohishi K, Miyake T, Imai K, Suzushima H, Mitsui H, Togitani K, Kiguchi T, Atsuta Y, Ohtake S, Ohnishi K, Kobayashi Y, Kiyoi H, Miyazaki Y, Naoe T; Japan Adult Leukemia Study Group.

Int J Hematol     2017.9

Clinical effectiveness of geriatric assessment for predicting the tolerability of outpatient chemotherapy in older adults with cancer. Reviewed

Hayashi N, Matsuoka A, Goto H, Gotoh M, Kiyoi H, Kodera Y, Nagino M, Nagashima F, Ando Y.

J Geriatr Oncol     2017.8

Phase II study of intrabone single unit cord blood transplantation for hematological malignancies. Reviewed

Murata M, Maeda Y, Masuko M, Onishi Y, Endo T, Terakura S, Ishikawa Y, Iriyama C, Ushijima Y, Goto T, Fujii N, Tanimoto M, Kobayashi H, Shibasaki Y, Fukuhara N, Inamoto Y, Suzuki R, Kodera Y, Matsushita T, Kiyoi H, Naoe T, Nishida T.

Cancer Sci   Vol. 108   page： 1634-1639   2017.6

MOLECULAR MARKERS PREDICTING RESPONSE TO AZACITIDINE TREATMENT FOR MYELODYSPLASTIC SYNDROMES

Nannya Y., Takeda J., Shiozawa Y., Shiraishi Y., Okuno Y., Kataoka K., Chiba K., Tanaka H., Sanada M., Chiba S., Asou N., Kiyoi H., Imai K., Hirase C., Dobashi N., Kiguchi T., Nakao S., Ohyashiki K., Miyazaki Y., Naoe T., Makishima H., Miyano S., Yoshida K., Ogawa S.

HAEMATOLOGICA   Vol. 102   page： 98-99   2017.6

Management of infection during chemotherapy for acute leukemia in Japan: a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group. Reviewed

Kimura SI, Fujita H, Kato H, Hiramoto N, Hosono N, Takahashi T, Shigeno K, Hatsumi N, Minamiguchi H, Miyatake J, Handa H, Akiyama N, Kanda Y, Yoshida M, Kiyoi H, Miyazaki Y, Naoe T; Japan Adult Leukemia Study Group (JALSG).

Support Care Cancer   Vol. 25   page： 3515-3521   2017.6

[I.Genetic Abnormalities Associated with Acute Leukemia and a Development of Molecular Therapies].

Adachi Y, Kiyoi H

Gan to kagaku ryoho. Cancer & chemotherapy   Vol. 44 ( 5 ) page： 380-385   2017.5

YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma. Reviewed

Kojima Y, Hayakawa F, Morishita T, Sugimoto K, Minamikawa Y, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H.

Pharmacol Res   Vol. 120   page： 242-251   2017.4

Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia. Reviewed International journal

Togasaki E, Takeda J, Yoshida K, Shiozawa Y, Takeuchi M, Oshima M, Saraya A, Iwama A, Yokote K, Sakaida E, Hirase C, Takeshita A, Imai K, Okumura H, Morishita Y, Usui N, Takahashi N, Fujisawa S, Shiraishi Y, Chiba K, Tanaka H, Kiyoi H, Ohnishi K, Ohtake S, Asou N, Kobayashi Y, Miyazaki Y, Miyano S, Ogawa S, Matsumura I, Nakaseko C, Naoe T.

Blood Cancer J   Vol. 7 ( 4 ) page： e559   2017.4

Impact of T-cell chimerism on relapse after cord blood transplantation for hematological malignancies: Nagoya Blood and Marrow Transplantation Group study. Reviewed International journal

Yokohata E, Kuwatsuka Y, Ohashi H, Terakura S, Kawashima N, Seto A, Kurahashi S, Ozawa Y, Goto T, Imahashi N, Nishida T, Miyao K, Sakemura R, Kato T, Sawa M, Kohno A, Sao H, Iida H, Kiyoi H, Naoe T, Miyamura K, Murata M.

Bone Marrow Transplant   Vol. 52 ( 4 ) page： 612 - 614   2017.4

Retrospective analysis of in vivo recovery and clearance during continuous infusion of recombinant factor VIII products: a single-institution study

Suzuki N., Hirakawa A., Kishimoto M., Kanematsu T., Ogawa M., Kiyoi H., Matsushita T.

HAEMOPHILIA   Vol. 23 ( 2 ) page： 215-221   2017.3

Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism.

Aoki T, Shimada K, Sakamoto A, Sugimoto K, Morishita T, Kojima Y, Shimada S, Kato S, Iriyama C, Kuno S, Harada Y, Tomita A, Hayakawa F, Kiyoi H.

Oncotarget   Vol. 8   page： 13085-13098   2017.2

Malignant lymphoma with cardiac involvement. Reviewed

Terakura S, Onji M, Iriyama C, Goto T, Ushijima Y, Shimada K, Ishikawa Y, Nishida T, Hayakawa F, Murata M, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 58 ( 3 ) page： 239 - 242   2017

A Tet-On Inducible System for Controlling CD19-Chimeric Antigen Receptor Expression upon Drug Administration. Reviewed

Sakemura R, Terakura S, Watanabe K, Julamanee J, Takagi E, Miyao K, Koyama D, Goto T, Hanajiri R, Nishida T, Murata M, Kiyoi H.

Cancer Immunol Res.   Vol. 4 ( 8 ) page： 658-68   2016.8

SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. Reviewed

Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A, Kiyoi H.

Cancer Sci.     page： [Epub ahead of print]   2016.6

PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation. Reviewed

Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, Naoe T, Kiyoi H.

Biochem Biophys Res Commun.   Vol. 475 ( 2 ) page： 176-81   2016.6

Peripheral blood cell-free DNA is an alternative tumor DNA source reflecting disease status in myelodysplastic syndromes. Reviewed

Suzuki Y, Tomita A, Nakamura F, Iriyama C, Shirahata-Adachi M, Shimada K, Akashi A, Ishikawa Y, Kaneda N, Kiyoi H.

Cancer Sci.     page： [Epub ahead of print]   2016.6

Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells. Reviewed

Chen F, Ishikawa Y, Akashi A, Naoe T, Kiyoi H.

Oncotarget.     page： [Epub ahead of print]   2016.6

Live-cell single-molecule imaging of the cytokine receptor MPL for analysis of dynamic dimerization. Reviewed

Sakamoto A, Tsukamoto T, Furutani Y, Sudo Y, Shimada K, Tomita A, Kiyoi H, Kato T, Funatsu T.

J Mol Cell Biol.     page： [Epub ahead of print]   2016.6

BCR-ABL-specific CD4+ T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells. Reviewed

Ueda N, Zhang R, Tatsumi M, Liu TY, Kitayama S, Yasui Y, Sugai S, Iwama T, Senju S, Okada S, Nakatsura T, Kuzushima K, Kiyoi H, Naoe T, Kaneko S, Uemura Y.

Cell Mol Immunol     page： [Epub ahead of print]   2016.5

Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells. Reviewed

Maeda K, Enomoto A, Hara A, Asai N, Kobayashi T, Horinouchi A, Maruyama S, Ishikawa Y, Nishiyama T, Kiyoi H, Kato T, Ando K, Weng L, Mii S, Asai M, Mizutani Y, Watanabe O, Hirooka Y, Goto H, Takahashi M.

Sci Rep.   Vol. 6   page： 22288   2016.2

B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia. Reviewed

Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.

J Biol Chem.   Vol. 291 ( 9 ) page： 4723-31   2016.2

The first case of antithrombin-resistant prothrombin Belgrade mutation in Japanese. Reviewed

Kishimoto M, Suzuki N, Murata M, Ogawa M, Kanematsu T, Takagi A, Kiyoi H, Kojima T, Matsushita T.

Ann Hematol.   Vol. 95 ( 3 ) page： 541-2   2016.2

A case of MYH9 disorders caused by a novel mutation (p.K74E). Reviewed

Kanematsu T, Suzuki N, Yoshida T, Kishimoto M, Aoki T, Ogawa M, Kagami Y, Kiyoi H, Matsushita T, Kunishima S.

Ann Hematol   Vol. 95 ( 1 ) page： 161-3   2016.1

Clinical usefulness of WT1 mRNA expression in bone marrow detected by a new WT1 mRNA assay kit for monitoring acute myeloid leukemia: a comparison with expression of WT1 mRNA in peripheral blood. Reviewed

Kitamura K, Nishiyama T, Ishiyama K, Miyawaki S, Miyazaki K, Suzuki K, Masaie H, Okada M, Ogawa H, Imai K, Kiyoi H, Naoe T, Yokoyama Y, Chiba S, Hata T, Miyazaki Y, Hatta Y, Takeuchi J, Nannya Y, Kurokawa M, Ueda Y, Koga D, Sugiyama H, Takaku F.

Int J Hematol.   Vol. 103 ( 1 ) page： 53-62   2016.1

High-dose chemotherapy followed by autologous stem cell transplantation for relapsed/refractory primary mediastinal large B-cell lymphoma. Reviewed

Aoki T, Shimada K, Suzuki R, Izutsu K, Tomita A, Maeda Y, Takizawa J, Mitani K, Igarashi T, Sakai K, Miyazaki K, Mihara K, Ohmachi K, Nakamura N, Takasaki H, Kiyoi H, Nakamura S, Kinoshita T, Ogura M.

Blood Cancer J.   Vol. 5   page： e372   2015.12

Overview: A New Era of Cancer Genome in Myeloid Malignancies. Invited Reviewed

Kiyoi H.

Oncology.   Vol. 89 ( Suppl 1 ) page： 1-3   2015.11

Phase I trial of volasertib, a Polo-like kinase inhibitor, in Japanese patients with acute myeloid leukemia. Reviewed

Kobayashi Y, Yamauchi T, Kiyoi H, Sakura T, Hata T, Ando K, Watabe A, Harada A, Taube T, Miyazaki Y, Naoe T.

Cancer Sci.   Vol. 106 ( 11 ) page： 1590-5   2015.11

Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells. Reviewed

Sugimoto K, Hayakawa F, Shimada S, Morishita T, Shimada K, Katakai T, Tomita A, Kiyoi H, Naoe T.

Sci Rep.   Vol. 5   page： 13054   2015

Integration of humoral and cellular HLA-specific immune responses in cord blood allograft rejection. Reviewed

Hanajiri R, Murata M, Sugimoto K, Murase M, Sakemura R, Goto T, Watanabe K, Imahashi N, Terakura S, Ohashi H, Akatsuka Y, Kurahashi S, Miyamura K, Kiyoi H, Nishida T, Naoe T.

Bone Marrow Transplant   Vol. 50   page： 1187-94   2015

FLT3 Inhibitors: Recent Advances And Problems For Clinical Application. Invited Reviewed

Kiyoi H

Nagoya J Med Sci   Vol. 77   page： 7-17   2015

Chimerism status after unrelated donor bone marrow transplantation with fludarabine-melphalan conditioning is affected by the melphalan dose and is predictive of relapse. Reviewed

Imahashi N, Ohashi H, Terakura S, Miyao K, Sakemura R, Kato T, Sawa M, Yokohata E, Kurahashi S, Ozawa Y, Nishida T, Kiyoi H, Watamoto K, Kohno A, Kasai M, Kato C, Iida H, Naoe T, Miyamura K, Murata M; for the Nagoya Blood and Marrow Transplantation Group.

Ann Hematol   Vol. 94   page： 1139-48   2015

Simple and Efficient Generation of Virus-specific T Cells for Adoptive Therapy Using Anti-4-1BB Antibody. Reviewed

Imahashi N, Nishida T, Goto T, Terakura S, Watanabe K, Hanajiri R, Sakemura R, Imai M, Kiyoi H, Naoe T, Murata M.

J Immunother.   Vol. 38   page： 62-70   2015

Target Antigen Density Governs the Efficacy of Anti-CD20-CD28-CD3 ζ Chimeric Antigen Receptor-Modified Effector CD8+ T Cells. Reviewed

Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M.

J Immunol.   Vol. 194   page： 911-20   2015

Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group. Reviewed

Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T; Japan Adult Leukemia Study Group (JALSG).

Blood Cancer J.   Vol. 4   page： e252   2014.10

De novo diffuse large B-cell lymphoma with a CD20 immunohistochemistry-positive and flow cytometry-negative phenotype: Molecular mechanisms and correlation with rituximab sensitivity. Reviewed

Tokunaga T, Tomita A, Sugimoto K, Shimada K, Iriyama C, Hirose T, Shirahata-Adachi M, Suzuki Y, Mizuno H, Kiyoi H, Asano N, Nakamura S, Kinoshita T, Naoe T.

Cancer Sci   Vol. 105   page： 35-43   2014

Efficacy of ofatumumab against rituximab-resistant B-CLL/SLL cells with low CD20 protein expression. Reviewed

Shimada K, Tomita A, Saito S, Kiyoi H.

Br J Haematol   Vol. 166   page： 455-457   2014

Expression of CD56 is an unfavorable prognostic factor for acute promyelocytic leukemia with higher initial white blood cell counts. Reviewed

Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Emi N, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Kimura Y, Iwanaga M, Asou N, Naoe T; The Japan Adult Leukemia Study Group.

Cancer Sci   Vol. 105   page： 97-104   2014

The demarcation between younger and older acute myeloid leukemia patients: a pooled analysis of 3 prospective studies. Reviewed

Yanada M, Ohtake S, Miyawaki S, Sakamaki H, Sakura T, Maeda T, Miyamura K, Asou N, Oh I, Miyatake J, Kanbayashi H, Takeuchi J, Takahashi M, Dobashi D, Kiyoi H, Miyazaki Y, Emi N, Kobayashi Y, Ohno R, Naoe T.

Cancer   ( 119 ) page： in press   2013

GATA2 zinc finger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation. Reviewed

Niimi K, Kiyoi H, Ishikawa Y, Hayakawa F, Kurahashi S, Kihara R, Tomita A and Naoe T.

Leukemia Research Reports   Vol. 2   page： 21-25   2013

Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation. Reviewed

Ando K, Tsushima H, Matsuo E, Horio K, Tominaga-Sato S, Imanishi D, Imaizumi Y, Iwanaga M, Itonaga H, Yoshida S, Hata T, Moriuchi R, Kiyoi H, Nimer S, Mano H, Naoe T, Tomonaga M, Miyazaki Y.

J Biol Chem   Vol. 288   page： 9457-9467   2013

Gene mutations of acute myeloid leukemia in the genome era. Invited Reviewed

Naoe T, Kiyoi H

Int J Hematol   Vol. 97   page： 165-174   2013

Guest editorial: efficacy of and resistance to molecularly targeted therapy for myeloid malignancies. Invited Reviewed

Kiyoi H.

Int J Hematol   Vol. 97   page： 681-682   2013

Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97. Reviewed

Fujita H, Asou N, Iwanaga M, Hyo R, Nomura S, Kiyoi H, Okada M, Inaguma Y, Matsuda M, Yamauchi T, Ohtake S, Izumi T, Nakaseko C, Ishigatsubo Y, Shinagawa K, Takeshita A, Miyazaki Y, Ohnishi K, Miyawaki S, Naoe T; Japan Adult Leukemia Study Group.

Cancer Sci   Vol. 104   page： 1339-45   2013

Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in acute promyelocytic leukemia. Invited Reviewed

Tomita A, Kiyoi H, Naoe T.

Int J Hematol   Vol. 97   page： 717-725   2013

Molecular lesions in childhood and adult acute megakaryoblastic leukaemia.

Hama A, Muramatsu H, Makishima H, Sugimoto Y, Szpurka H, Jasek M, O'Keefe C, Takahashi Y, Sakaguchi H, Doisaki S, Shimada A, Watanabe N, Kato K, Kiyoi H, Naoe T, Kojima S, Maciejewski JP.

Br J Haematol   Vol. 156   page： 316-325   2012

Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin. Reviewed

Kajiguchi T, Katsumi A, Tanizaki R, Kiyoi H, Naoe T

Eur J Haematol   Vol. 88   page： 314-20   2012

Long-term outcome of imatinib therapy, with assessment of its dosage and blood levels, for chronic myelogenous leukemia. Reviewed

Ohnishi K, Nakaseko C, Takeuchi J, Fujisawa S, Nagai T, Yamazaki H, Tauchi T, Imai K, Mori N, Yagasaki F, Maeda Y, Usui N, Miyazaki Y, Miyamura K, Kiyoi H, Ohtake S, Naoe T.

Cancer Sci   Vol. 103   page： 1071-1078   2012

Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome. Reviewed

Iriyama C, Tomita A, Hoshino H, Shirahata M, Furukawa-Hibi Y, Yamada K, Kiyoi H, Naoe T.

Biochem Biophys Res Commun   Vol. 419   page： 662-9   2012

CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737. Reviewed

Shimada K, Tomita A, Minami Y, Abe A, Hind CK, Kiyoi H, Cragg MS, Naoe T.

Exp Hematol   Vol. 40   page： 724-737   2012

Randomized comparison of fixed-schedule versus response-oriented individualized induction therapy and use of ubenimex during and after consolidation therapy for elderly patients with acute myeloid leukemia: the JALSG GML200 Study. Reviewed

Wakita A, Ohtake S, Takada S, Yagasaki F, Komatsu H, Miyazaki Y, Kubo K, Kimura Y, Takeshita A, Adachi Y, Kiyoi H, Yamaguchi T, Yoshida M, Ohnishi K, Miyawaki S, Naoe T, Ueda R, Ohno R.

Int J Hematol   Vol. 96   page： 84-93   2012

Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia. Reviewed

Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S.

Blood   Vol. 120   page： 1485-8   2012

Long-term outcome and prognostic factors of elderly patients with acute promyelocytic leukemia. Reviewed

Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Kimura Y, Iwanaga M, Asou N, Naoe T.

Cancer Sci   Vol. 103 ( 11 ) page： 1974-1978   2012

Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: JALSG AML201 Study. Reviewed

Ohtake S, Miyawaki S, Fujita H, Kiyoi H, Shinagawa K, Usui N, Okumura H, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R.

Blood   Vol. 117 ( 117 ) page： 2358-2365   2011

A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib-resistance: sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis. Reviewed

Sakai K, Ishikawa Y, Mori Y, Kobayashi M, Iriyama C, Ozawa Y, Suzuki T, Minami Y, Ishikawa K, Kaneda N, Naoe T, Kiyoi H.

Int J Hematol   Vol. 93   page： 237-242   2011

Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. Reviewed

Katsumi A, Nishida T, Murata M, Terakura S, Shimada K, Saito S, Kobayashi M, Kodaira A, Shibata S, Oda I, Yagi T, Kiyoi H, Matsushita T, Kojima T, Naoe T.

J Clin Exp Hematop   Vol. 51   page： 63-65   2011

Phase I trial of gemtuzumab ozogamicin in intensive combination chemotherapy for relapsed or refractory adult acute myeloid leukemia (AML): Japan Adult Leukemia Study Group (JALSG)-AML206 study. Reviewed

Usui N, Takeshita A, Nakaseko C, Dobashi N, Fujita H, Kiyoi H, Kobayashi Y, Sakura T, Yahagi Y, Shigeno K, Ohwada C, Miyazaki Y, Ohtake S, Miyawaki S, Naoe T, Ohnishi K

Cancer Sci   Vol. 102   page： 1358-1365   2011

Prevalence and clinical characteristics of N-terminally truncated WT1 expression in acute myeloid leukemia. Reviewed

Ishikawa Y, Kiyoi H, Naoe T.

Leuk Res   Vol. 35   page： 685-688   2011

A randomized comparison of four courses of standard-dose multiagent chemotherapy versus three courses of high-dose cytarabine alone in post-remission therapy for acute myeloid leukemia in adults: the JALSG AML201 study. Reviewed

Miyawaki S, Ohtake S, Fujisawa S, Kiyoi H, Shinagawa K, Usui N, Sakura T, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R.

Blood   Vol. 117   page： 2366-2372   2011

FLT3/ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signaling. Reviewed

Katsumi A, Kiyoi H, Abe A, Tanizaki R, Iwasaki T, Kobayashi M, Matsushita T, Senga T, Kohno T, Kojima T, Kaibuchi K, Hamaguchi M, Naoe T.

Eur J Haematol   Vol. 86   page： 191-198   2011

Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study. Reviewed

Ishikawa Y, Kiyoi H, Watanabe K, Miyamura K, Nakano Y, Kitamura K, Kohno A, Sugiura I, Yokozawa T, Hanamura A, Yamamoto K, Iida H, Emi N, Suzuki R, Ohnishi K, Naoe T.

Cancer Sci   Vol. 101   page： 2186-2192   2010.10

Imatinib for newly diagnosed chronic-phase chronic myeloid leukemia: results of a prospective study in Japan. Reviewed

Nagai T, Takeuchi J, Dobashi N, Kanakura Y, Taniguchi S, Ezaki K, Nakaseko C, Hiraoka A, Okada M, Miyazaki Y, Motoji T, Higashihara M, Tsukamoto N, Kiyoi H, Nakao S, Shinagawa K, Ohno R, Naoe T, Ohnishi K, Usui N.

Int J Hematol   Vol. 92   page： 111-117   2010.7

Array-based genomic resequencing of human leukemia. Reviewed

Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, Mano H.

Oncogene   Vol. 29   page： 3723-3731   2010.6

BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4. Reviewed

Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T.

Eur J Haematol   Vol. 84   page： 229-238   2010

Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD / SCID / IL-2Rgammac mice. Reviewed

Tanizaki R, Nomura Y, Miyata Y, Minami Y, Abe A, Hanamura A, Sawa M, Murata M, Kiyoi H, Matsushita T, Naoe T.

Cancer Sci   Vol. 101   page： 631-638   2010

Randomized trial of response-oriented individualized versus fixed-schedule induction chemotherapy with idarubicin and cytarabine in adult acute myeloid leukemia: the JALSG AML95 study. Reviewed

Ohtake S, Miyawaki S, Kiyoi H, Miyazaki Y, Okumura H, Matsuda S, Nagai T, Kishimoto Y, Okada M, Takahashi M, Handa H, Takeuchi J, Kageyama S, Asou N, Yagasaki F, Maeda Y, Ohnishi K, Naoe T, Ohno R.

Int J Hematol   Vol. 91   page： 276-283   2010

Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia. Reviewed

Tsujimura A, Kiyoi H, Shiotsu Y, Ishikawa Y, Mori Y, Ishida H, Toki T, Ito E, Naoe T.

Int J Hematol   Vol. 92   2010

Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. Reviewed

Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R.

J Clin Oncol   Vol. 28   page： 1591-1598   2010

Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment. Reviewed

Minami Y, Kajiguchi T, Abe A, Ohno T, Kiyoi H, Naoe T.

Int J Hematol   Vol. 92   page： 664-666   2010

Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance. Reviewed

Hiraga J, Tomita A, Sugimoto T, Shimada K, Ito M, Nakamura S, Kiyoi H, Kinoshita T, Naoe T.

Blood   Vol. 113   page： 4885-4893   2009

Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. Reviewed

Inamoto Y, Murata M, Katsumi A, Kuwatsuka Y, Tsujimura A, Ishikawa Y, Sugimoto K, Onizuka M, Terakura S, Nishida T, Kanie T, Taji H, Iida H, Suzuki R, Abe A, Kiyoi H, Matsushita T, Miyamura K, Kodera Y, Naoe T.

Bone Marrow Transplant   Vol. 45   page： 363-369   2009

Escape mechanisms from antibody therapy to lymphoma cells: downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation. Reviewed

Sugimoto T, Tomita A, Hiraga J, Shimada K, Kiyoi H, Kinoshita T, Naoe T.

Biochem Biophys Res Commun   Vol. 390   page： 48-53   2009

CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma. Reviewed

Takeshita A, Shinjo K, Yamakage N, Ono T, Hirano I, Matsui H, Shigeno K, Nakamura S, Tobita T, Maekawa M, Ohnishi K, Sugimoto Y, Kiyoi H, Naoe T, Ohno R.

Br J Haematol   Vol. 146   page： 34-43   2009

CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells. Reviewed

Takeshita A, Yamakage N, Shinjo K, Ono T, Hirano I, Nakamura S, Shigeno K, Tobita T, Maekawa M, Kiyoi H, Naoe T, Ohnishi K, Sugimoto Y, Ohno R.

Leukemia   Vol. 23   page： 1329-1336   2009

Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia. Reviewed

Ishikawa Y, Kiyoi H, Tsujimura A, Miyawaki S, Miyazaki Y, Kuriyama K, Tomonaga M, Naoe T.

Eur J Haematol   Vol. 83   page： 90-98   2009

Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome. Reviewed

10. Xu J, Suzuki M, Niwa Y, Hiraga J, Nagasaka T, Ito M, Nakamura S, Tomita A, Abe A, Kiyoi H, Kinoshita T, Naoe T.

Br J Haematol.   Vol. 140   page： 394-401   2008

Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. Reviewed

Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang JY, Naoe T.

Int J Hematol   Vol. 88   page： 471-475   2008

Prognostic implication and biological roles of RhoH in acute myeloid leukaemia. Reviewed

Iwasaki T, Katsumi A, Kiyoi H, Tanizaki R, Ishikawa Y, Ozeki K, Kobayashi M, Abe A, Matsushita T, Watanabe T, Amano M, Kojima T, Kaibuchi K, Naoe T.

Eur J Haematol   Vol. 81   page： 454-460   2008

Mutational analysis of SOS1 gene in acute myeloid leukemia. Reviewed

Tanizaki R, Katsumi A, Kiyoi H, Kunishima S, Iwasaki T, Ishikawa Y, Kobayashi M, Abe A, Matsushita T, Watanabe T, Kojima T, Kaibuchi K, Kojima S, Naoe T.

Int J Hematol   Vol. 88   2008

Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors. Reviewed

Ishida H, Isami S, Matsumura T, Umehara H, Yamashita Y, Kajita J, Fuse E, Kiyoi H, Naoe T, Akinaga S, Shiotsu Y, Arai H.

Bioorg Med Chem Lett.   Vol. 18   page： 5472-5477   2008

Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan. Reviewed

Narimatsu H, Iino M, Ichihashi T, Yokozawa T, Hayakawa M, Kiyoi H, Takeo T, Sawamoto A, Iida H, Tsuzuki M, Yanada M, Naoe T, Suzuki R, Sugiura I.

Int J Hematol   Vol. 88   2008

Karyotypically independent clones with del(11q) and trisomy 10 in acute myeloid leukemia: trisomy 10 may appear as an additional change. Reviewed

Gotoh M, Sasaki Y, Iguchi T, Fujimoto H, Kodama A, Kiyoi H, Naoe T, Ohyashiki K.

Int J Hematol   Vol. 88   page： 123-124   2008

Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review. Reviewed

Murata M, Ishikawa Y, Ohashi H, Terakura S, Ozeki K, Kiyoi H, Naoe T.

Int J Hematol   Vol. 88   page： 111-115   2008

Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome. Reviewed

Sato T, Toki T, Kanezaki R, Xu G, Terui K, Kanegane H, Miura M, Adachi S, Migita M, Morinaga S, Nakano T, Endo M, Kojima S, Kiyoi H, Mano H, Ito E.

Br J Haematol.   Vol. 141   page： 681-688   2008

Mutations of JAK2, JAK3 and GATA1 in acute megakaryoblastic leukemia of Down syndrome. Reviewed

8. Hama A, Yagasaki H, Takahashi Y, Matsumoto K, Kiyoi H, Kojima S.

Blood   Vol. 111   page： 2493-2494   2008

Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan. Reviewed

9. Narimatsu H, Yokozawa T, Iida H, Tsuzuki M, Hayakawa M, Takeo T, Iino M, Ichihashi T, Kato C, Sawamoto A, Sao H, Yanada M, Emi N, Kiyoi H, Yamaguchi T, Naoe T, Suzuki R, Sugiura I.

Leukemia   Vol. 22   page： 432-434   2008

Clinical features and outcome of T-lineage acute lymphoblastic leukemia in adults: A low initial white blood cell count, as well as a high count predict decreased survival rates. Reviewed

Yanada M, Jinnai I, Takeuchi J, Ueda T, Miyawaki S, Tsuzuki M, Hatta Y, Usui N, Wada H, Morii T, Matsuda M, Kiyoi H, Okada M, Honda S, Miyazaki Y, Ohno R, Naoe T.

Leukemia Res   Vol. 31   2007

LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). Reviewed

Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T.

Eur J Haematol.   Vol. 78   2007

FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells. Reviewed

Kajiguchi T, Chung EJ, Lee S, Stine A, Kiyoi H, Naoe T, Levis MJ, Neckers L, Trepel JB.

Leukemia   Vol. 21   2007

Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan. Reviewed

Narimatsu H, Yokozawa T, Iida H, Tsuzuki M, Hayakawa M, Takeo T, Iino M, Ichihashi T, Kato C, Sawamoto A, Sao H, Yanada M, Emi N, Kiyoi H, Yamaguchi T, Naoe T, Suzuki R, Sugiura I.

Leukemia   Vol. 21   2007

High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia. Reviewed

Narimatsu H, Emi N, Kohno A, Iwai M, Yanada M, Yokozawa T, Saito S, Shimada K, Kiyoi H, Naoe T, Yamamoto K, Morishita Y.

Bone Marrow Transplant   Vol. 40   2007

Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma. Reviewed

Hiraga J, Katsumi A, Iwasaki T, Abe A, Kiyoi H, Matsushita T, Kinoshita T, Naoe T.

Leukemia   Vol. 21   2007

Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. Reviewed

Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T.

Leukemia   Vol. 21   page： 136   2007

Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD. Reviewed

Okamoto M, Hayakawa F, Miyata Y, Watamoto K, Emi N, Abe A, Kiyoi H, Towatari M, Naoe T.

Leukemia   Vol. 21   page： 403   2007

JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. Reviewed

Kiyoi H, Yamaji S, Kojima, Naoe T.

Leukemia   Vol. 21   page： 574   2007

Epegenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with Rituximab-containing chemotherapy. Reviewed

Tomita A, Hiraga J, Kiyoi H, Ninomiya M, Sugimoto T, Ito M, Kinoshita T, Naoe T.

Int J Hematol   Vol. 84   2007

A novel FLT3 inhibitor FI-700 selectively suppress the growth of leukemia cells with FLT3 mutations. Reviewed

Kiyoi H, Shiotsu Y, Ozeki K, Yamaji S, Kosugi H, Umehara H, Arai H, Ishii K, Akinaga S, Naoe T.

Clin Cancer Res   Vol. 13   page： 4575-4582   2007

Successful second cord blood transplantation using fludarabine and cyclophosphamide as a preparative regimen for graft rejection following reduced-intensity cord blood transplantation. Reviewed

Mizutani E, Narimatsu H, Murata M, Tomita A, Kiyoi H, Naoe T.

Bone Marrow Tranaplant   Vol. 32   2007

A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RAR{alpha} transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study. Reviewed

Asou N, Kishimoto Y, Kiyoi H, Okada M, Kawai Y, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Kobayashi T, Ohtake S, Nishimura M, Takahashi M, Yagasaki F, Takeshita A, Kimura Y, Iwanaga M, Naoe T, Ohno R.

Blood   Vol. 107   2007

Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo. Reviewed

Atsumi A, Tomita A, Kiyoi H, Naoe T.

BBRC   Vol. 345   page： 1471   2006

Establishment of a Stroma-Dependent Human Acute Myelomonocytic Leukemia Cell Line, NAMO-2, with FLT3 Tandem Duplication. Reviewed

Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A, Emi N, Naoe T.

Int J Hematol   Vol. 84   page： 328   2006

Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. Reviewed

Karnan S, Tsuzuki S, Kiyoi H, Tagawa H, Ueda R, Seto M, Naoe T.

Gene Chromosome Canc   Vol. 45   page： 420   2006

Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation. Reviewed

Yanada M, Matsushita T, Suzuki M, Kiyoi H, Yamamoto K, Kinoshita T, Kojima T, Saito H, Naoe T.

Eur J Haematol   Vol. 77   page： 282   2006

Nucleophosmin: a versatile molecule associated with hematological malignancies. Reviewed

Naoe T, Suzuki T, Kiyoi H, Urano T.

Cancer Sci   Vol. 97   page： 963   2006

Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene. Reviewed

Ninomiya M, Abe A, Yokozawa T, Ozeki K, Yamamoto K, Ito M, Ito M, Kiyoi H, Emi N, Naoe T.

Cancer Genet Cytogen   Vol. 169   page： 1   2006

Biology, clinical relevance, and moleculary targeted therapy in acute leukemia with FLT3 mutations. Invited Reviewed

Kiyoi H, Naoe T.

Int J Hematol   Vol. 83   page： 301   2006

FLT3 mutations in acute myeloid leukemia. Invited Reviewed

Kiyoi H, Naoe T.

Meth Molec Med   Vol. 125   page： 189   2006

PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. Reviewed

Yamamoto T, Isomura M, Xu Y, Liang J, Yagasaki H, Kamachi Y, Kudo K, Kiyoi H, Naoe T, Kojma S.

Leukemia Res   Vol. 30   page： 1085   2006

Mutations of N-RAS, FLT3 and p53 genes are not involved in the development of acute leukemia transformed from myeloproliferative diseases with JAK2 mutation. Reviewed

Suzuki M, Abe A, Kiyoi H, Murata M, Ito Y, Shimada K, Morishita Y, Kinoshita T, Naoe T.

Leukemia   Vol. 20   page： 1168   2006

Micafungin, a novel antifungal agent, as empirical therapy in acute leukemia patients with febrile neutropenia. Reviewed

Yanada M, Kiyoi H, Murata M, Suzuki M, Iwai M, Yokozawa T, Baba H, Emi N, Naoe T.

Intern Med   Vol. 45   page： 259   2006

*Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia. Reviewed

Suzuki T, Kiyoi H, Ozeki K, Tomita A, Yamaji S, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Kinoshita T, Emi N, Naoe T.

Blood   Vol. 106   page： 2854   2005

Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome. Reviewed

Iwai M, Kiyoi H, Ozeki K, Kinoshita T, Emi N, Ohno R, Naoe T.

Leukemia   Vol. 19   page： 1367   2005

Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis. Reviewed

Yanada M, Matsuo K, Suzuki T, Kiyoi H, Naoe T.

Leukemia   Vol. 19   page： 1345   2005

Clinical significance of FLT3 in leukemia. Invited Reviewed

Kiyoi H, Yanada M, Ozeki K.

Int J Hematol   Vol. 82   page： 85   2005

BMI-1 Is Highly Expressed in M0-Subtype Acute Myeloid Leukemia. Reviewed

Sawa M, Yamamoto K, Yokozawa T, Kiyoi H, Hishida A, Kajiguchi T, Seto M, Kohno A, Kitamura K, Itoh Y, Asou N, Hamajima N, Emi N, Naoe T.

Int J Hematol   Vol. 82   page： 42   2005

Long-term outcomes for unselected patients with acute myeloid leukemia categorized according to the World Health Organization classification: a single-center experience. Reviewed

Yanada M, Suzuki M, Kawashima K, Kiyoi H, Kinoshita T, Emi N, Saito H, Naoe T.

Eur J Haematol   Vol. 74   page： 418   2005

*Biological and clinical significance of the FLT3 transcript level in acute myeloid leukemia. Reviewed

Ozeki K, Kiyoi H, Hirose Y, Iwai M, Ninomiya M, Kodera Y, Miyawaki S, Kuriyama K, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Ohno R, Emi N, Naoe T.

Blood   Vol. 103   page： 1901   2004

Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia. Reviewed

Yanada M, Terakura S, Yokozawa T, Yamamoto K, Kiyoi H, Emi N, Kitamura K, Kohno A, Tanaka M, Tobita T, Takeo T, Sao H, Kataoka T, Kobayashi M, Takeshita A, Morishita Y, Sugiura I, Naoe T.

Leukemia Lymphoma   Vol. 45   page： 1803   2004

Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line. Reviewed

Ninomiya M, Kiyoi H, Ito M, Hirose Y, Ito M, Naoe T.

Leukemia   Vol. 18   page： 442   2004

Normal and oncogenic FLT3. Invited Reviewed

Naoe T, Kiyoi H.

Cell Mol Life Sci   Vol. 61   page： 2932   2004

Different anti-apoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. Reviewed

Minami Y, Yamamoto K, Kiyoi H, Ueda R, Saito H, Naoe T.

Blood   Vol. 102   page： 2969   2003

Comprehensive analysis of gene alterations in acute megakaryoblastic leukemia of Down syndrome. Reviewed

Hirose Y, Kudo K, Kiyoi H, Hayashi Y, Naoe T, Kojima S.

Leukemia   Vol. 17   page： 2250   2003

A xeno-transplantable plasma cell leukemia line with a split translocation of the IgH gene. Reviewed

Ohbayashi K, Taniwaki M, Ninomiya M, Kiyoi H, Iida S, Ueda R, Naoe T.

Cancer Genet Cytogen   Vol. 144   page： 31   2003

Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy Reviewed

Leukemia   Vol. 16   page： 203-208   2002

FLT3 in human hematologic malignancies. Invited Reviewed

Kiyoi H, Naoe T.

Leukemia Lymphoma   Vol. 43   page： 1541   2002

Rapid screening of leukemia fusion transcripts in acute leukemia by Real-time PCR. Reviewed

Osumi K, Fukui T, Kiyoi H, Kasai M, Kodera Y, Kudo K, Kato K, Matsuyama M, Naito K, Tamimoto M, Hirai H, Saito H, Ohno R, Naoe T.

Leukemia Lymphoma   Vol. 43   page： 2291   2002

Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11 Reviewed

Leukemia   Vol. 16   page： 2205-2212   2002

Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors Reviewed

Leukemia   Vol. 16   page： 1535-1540   2002

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain Reviewed

Kiyoi H, Ohno R, Ueda R, Saito H, Naoe T.

Oncogene   Vol. 21   page： 2555-2563   2002

Successful treatment with imatinib mesylate of a CML patient in megakaryoblastic crisis with severe fibrosis. Reviewed

Hirose Y, Kiyoi H, Iwai M, Yokozawa T, Ito M, Naoe T.

Int J Hematol   Vol. 76   page： 349   2002

Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations Reviewed

Jpn J Cancer Res   Vol. 92   page： 638-644   2001

B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells Reviewed

Immunology   Vol. 104   page： 410-417   2001

FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy Reviewed

Cancer Chemother Pharmacol   Vol. 48   page： 27-30   2001

Immunoglobulin variable region structure and B cell malignancies. Reviewed

Kiyoi H, Naoe T.

Int J Hematol   Vol. 73   page： 47   2001

Prognostic significance of the cell cycle inhibitor p27Kip1 in acute myeloid leukemia.

Leukemia   Vol. 14   page： 28-33   2000

Leukemia relapse reconsidered from the molecular aspect.

Leukemia and Lymphoma   Vol. 37   page： 527-534   2000

Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid.

Br J Haematol   Vol. 108   page： 696-702   2000

Identification of a novel putative Ran-binding protein and its close homologue

Biochem Biophys Res Commun   Vol. 278   page： 241-249   2000

Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia. Reviewed

Clin Cancer Res   Vol. 6   page： 4091-4095   2000

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Reviewed

Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T.

Oncogene   Vol. 19   page： 624-631   2000

Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia.

Eur J Haematol   Vol. 65   page： 23-31   2000

In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor.

Leukemia   Vol. 14   page： 374-378   2000

Poor clinical significance of p53 gene polymorphism in acute myeloid leukemia.

Leuk Res   Vol. 24   page： 349-352   2000

Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis. Reviewed

Kitamura K, Minami Y, Yamamoto K, Akao Y, Kiyoi H, Saito H, Naoe T.

Leukemia   Vol. 14   page： 1743   2000

Review of the immunoglobulin light chain variable region sequences from multiple myeloma cells.

Leukemia   Vol. 13   page： 829-830   1999

Accurate quantitation of residual tumor burden at bone marrow harvest predicts timing of subsequent relapse in patients with common ALL treated by autologous bone marrow transplantation. Nagoya BMT Group.

Bone Marrow Transplant   Vol. 24   page： 777-784   1999

Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy.

Leukemia   Vol. 13   page： 1316-1324   1999

Molecular evolution of acute myeloid leukaemia in relapse : unstable N-ras and FLT3 genes compared with p53 gene.

Br J Haematol   Vol. 104   page： 659-664   1999

Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation.

Leukemia   Vol. 13   page： 585-589   1999

Etoposide-realted acute promyelocytic leukemia.

Leukemia   Vol. 12   page： 1171-1175   1998

Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia.

Br J Haematol   Vol. 101   page： 521-528   1998

Characterization of the immunoglobulin light chain variable region gene expressed in multiple myeloma.

Leukemia   Vol. 12   page： 601-609   1998

Prognostic significance of TEL/AML1 fusion transcript in childhood B-precursor acute lymphoblastic leukemia.

J Pediatr Hematolo/oncolo   Vol. 20   page： 190-195   1998

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines.

Leukemia   Vol. 11   page： 1605-1609   1997

Comparison of the immunoglobulin gene transcripts between immature B lineage acute lymphoblastic leukemia and the normal phenotypic counterparts in the bone marrow.

Leukemia   Vol. 11   page： 1274-1280   1997

Mutant AF-2 domain of PML-RARα in retinoic acid-resistant NB4 cells : differentiation induced by RA is triggered directly through PML-RARα and its down-regulation in acute promyelocytic leukemia.

Leukemia   Vol. 11   page： 1950-1956   1997

Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia.

Leukemia   Vol. 11   page： 1447-1452   1997

Unusual feature of the T-cell receptor genes in T-lineage acute lymphoblastic leukemia.

Leuk Res   Vol. 21   page： 667-674   1997

New retinoids and arsenic compounds for the treatment of refractory acute promyelocytic leukemia : clinical and basic studies for the next generation.

Cancer Chemotherapy & Pharmacology   Vol. 40   page： S36-S41   1997

Comparable gene structure of the immunoglobulin heavy chain variable region between multiple myeloma and normal bone marrow lymphocytes.

Leukemia   Vol. 10   page： 1804-1812   1996

Different T-cell receptor repertoires between lesions and peripheral blood in acute graft-versus-host disease after allogeneic bone marrow transplantation.

Blood   Vol. 87   page： 3019-3026   1996

Comparison of the immunoglobulin heavy-chain complementarity determining region-3 structure among the DNA sequences and the μ-and γ-transcripts in human B-lineage cells.

Immunology   Vol. 89   page： 324-330   1996

Comparable profiles of the immunoglobulin heavy chain complementarity determining region(CDR)-3 in CD5₊ and CD5_- human cord blood B lymphocytes.

Immunology   Vol. 85   page： 236-240   1995

Detection of minimal residual disease in patients with childhood common acute lymphoblastic leukemia after autologous bone marrow trasplantation with ex vivo purging and systemic IL-2 infusion : unsuccessful prediction of subsequent relapse.

Bone Marrow Transplant   Vol. 16   page： 437-442   1995

Continuing immunoglobulin heavy chain gene rearrangements in chronic myeloid leikemia with recurrent B-lymphoid blast crises after bone marrow transplantation.

Leukemia   Vol. 9   page： 265-270   1995

Analysis of the joining sequences of the t(15 ; 17)translocation in human acute pronyelocytic leukemia : sequence non-specific recombination between the PML and RARA genes within identical short stretches.

Genes, Chromosomes & Cancer   Vol. 12   page： 37-44   1995

Prognostic significance of the RT-PCR assay of PML-RARA trascripts in acute promyelocytic leukemia.

Leukemia   Vol. 9   page： 588-593   1995

Characterization of immunoglobulin heavy chain gene rearrangements in chronic myeloid leikemia with recurrent B-lymphoid blast crisis following bone marrow transplantation.

Int Med   Vol. 33   page： 786-789   1994

Minimal residual disease status in pre-B acute lymphoblastic leukemia patients after chemotherapy and bone marrow trasplantation : assessment of the antileukemic effects of chemotherapy and BMT.

Leuk Res   Vol. 17   page： 674-684   1993

Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia.

Jap J Cancer Res   Vol. 84   page： 379-387   1993

Involvement of the MLL/ALL-1 gene associated with multiple point mutations of the N-ras gene in acute myeloid leukemia with t(11 : 17)(q23 ; q25).

Blood   Vol. 82   page： 2260-2261   1993

Effective treatment of adult T cell leukemia/lymphoma with a novel oral antitumor agent, MST-16.

Oncology   Vol. 49   page： 333-335   1992

Characterization of the immunoglobulin heavy chain complementarity determining region(CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells. Reviewed

J Clin Invest   Vol. 89   page： 739-746   1992

Hermolytic uraemic syndrome during FK506 therapy.

Lancet   Vol. 340   page： 60-61   1992

Development of hyperthyroidism in donor and recipient after allogeneic bone marrow transplantation.

Bone Marrow Transplant   Vol. 10   page： 397-398   1992

Disappearance of minimal residual lymphoblastic leukemia cells 6 months after allogeneic bone marrow transplantation without GVHD. Reviewed

Bone Marrow Transplant   Vol. 8   page： 59-62   1991

A case of cALL relapse after allogeneic BMT : recurrence of recipient cell origin, initially determined as being that of donor cell origin by sex chromosome analysis. Reviewed

Br J Haematolo   Vol. 73   page： 420-422   1989

造血器腫瘍治療第2版　これは困ったぞ, どうしよう！・AMLのリスク分類とそれに基づく治療選択の現状は？

清井　仁（ Role： Joint author）

中外医学社  2010 

がんの分子標的と治療薬事典・FLT3

清井　仁（ Role： Joint author）

羊土社  2010 

臨床に直結する血液疾患診療のエビデンス・急性骨髄性白血病の予後因子

清井　仁（ Role： Joint author）

文光堂  2009 

WHO分類第4版による白血病・リンパ系腫瘍の病態学・急性骨髄性白血病および関連前駆細胞性腫瘍

清井　仁、直江知樹（ Role： Joint author）

中外医学社  2009 

造血器腫瘍アトラス　形態、免疫、染色体と遺伝子　第4版・急性骨髄性白血病におけるNPM1遺伝子突然変異

清井　仁（ Role： Joint author）

日本医事新報社  2009 

講義録　血液・造血器疾患学　フローサイトメトリ

清井　仁（ Role： Joint author）

メジカルビュー社  2008 

新しい診断と治療のABC・急性白血病・病因

清井　仁（ Role： Joint author）

最新医学社  2006 

分子標的療法の基礎と臨床・FLT3を標的にした白血病の治療

清井　仁、直江知樹（ Role： Joint author）

篠原出版新社  2005 

分子標的治療薬「作用機序と臨床」・細胞内シグナル伝達系を阻害する薬剤、チロシンキナーゼ阻害剤/FLT3阻害剤（MLN518, PKC412, CEP-701）

清井　仁（ Role： Joint author）

メディカルレビュー社  2005 

血液・固形腫瘍診断マニュアル改定版・タンパク分析法

清井　仁（ Role： Joint author）

フジメディカル出版  2002 

臨床血液実験操作法・免疫グロブリン遺伝子を用いたクローナリティーの解析

清井　仁（ Role： Joint author）

科学評論社  2000 

血液・固形腫瘍診断マニュアル・タンパク分析法

清井　仁（ Role： Joint author）

フジメディカル出版  2000 

別冊・医学のあゆみ：血液疾患-state of arts Ver. 2免疫グロブリン遺伝子による微量残存白血病の診断

清井　仁（ Role： Joint author）

医歯薬出版  1998 

図説臨床癌シリーズno. 17　白血病・リンパ腫　新版minimal residual disease (MRD)の検出とその意義

清井　仁、大野竜三（ Role： Joint author）

メジカルビュー社  1994 

免疫グロブリン遺伝子による微量残存白血病の診断、溝口秀昭、平井久丸、坂田洋一編集、別冊・医学のあゆみ：血液疾患-state of arts

清井　仁（ Role： Joint author）

医歯薬出版  1993 

Polymerase chain reaction for the detection of minimal residual B-cell clones using diversity of complementarity determining region (CDR) III. In “Cancer Chemotherapy: Challenges for the Future Volume 6” (Ed.)

Naoe T. Kiyoi H. Ohno R（ Role： Joint author）

Excerpta Medica  1991 

Current review　癌化学療法1990～91各臓器癌の化学療法：白血病・骨髄腫

清井　仁、山田一正（ Role： Joint author）

中外医学社  1990 

造血器腫瘍の病態に基づいた新規治療薬の選択】再発・難治性のB細胞性急性リンパ性白血病に対する二重特異性T細胞誘導(BiTE)抗体ブリナツモマブ Invited

川島直実、清井仁

血液内科   Vol. 81 ( 1 ) page： 30 - 34   2020.7

【病気とくすり2020　基礎と実践Expert's Guide】病原微生物・悪性新生物とくすり　悪性腫瘍　白血病 Invited

中島 麻梨絵, 石川 裕一, 清井 仁

薬局   Vol. 71 ( 4 ) page： 2061 - 2069   2020.3

【病気とくすり2020　基礎と実践Expert's Guide】病原微生物・悪性新生物とくすり　悪性腫瘍　悪性リンパ腫 Invited

村瀬 篤史, 島田 和之, 清井 仁

薬局   Vol. 71 ( 4 ) page： 2070 - 2077   2020.3

【病気とくすり2020　基礎と実践Expert's Guide】病原微生物・悪性新生物とくすり　悪性腫瘍　多発性骨髄腫 Invited

牛島洋子、清井仁

薬局   Vol. 71 ( 4 ) page： 2070 - 2077   2020.3

【急性白血病-最新の診断と治療-】開発中の薬剤　FLT3阻害薬 Invited

川島直実、清井仁

日本臨床   Vol. 78 ( 3 ) page： 499 - 506   2020.3

【白血病治療薬開発の現況】FLT3阻害薬 Invited

清井仁

医学と薬学   Vol. 77 ( 2 ) page： 205 - 211   2020.1

Development and Efficacy of a Novel Bromodomain and Extraterminal Domain Degrader K-256 in MYC/BCL2-Related Lymphoma International conference

Furukawa, K; Shimada, K; Esaki, M; Tanaka, K; Yamamoto, K; Mori, K; Kiyoi, H

BLOOD  2023.11.2 

Analysis of Metabolic Mechanism of CD19CAR-T with CD79A/CD40 Co-Stimulatory Domain Based on Comparison with Established CAR-Ts International conference

Takeuchi, Y; Terakura, S; Hirano, S; Yokota, H; Kuwano, S; Osaki, M; Adachi, Y; Imai, K; Julamanee, J; Hanajiri, R; Murata, M; Kiyoi, H

BLOOD  2023.11.2 

Novel CAR-T cell therapy for solid tumors targeting epithelial V-like antigen 1

Osaki, M; Terakura, S; Sunagawa, M; Kokuryo, T; Nishida, T; Murata, M; Kiyoi, H

CANCER SCIENCE  2023.2 

The efficacy of BTK inhibitor in IVLBCL preclinical mouse models.

Takai, M; Shimada, K; Kiyoi, H

CANCER SCIENCE  2023.2 

NDRG2はびまん性大細胞型B細胞リンパ腫の中枢神経病変において高発現を来す

村瀨篤史、島田和之、青木智広、真田昌、中杤昌弘、島田聡子、久納俊祐、中村栄男、清井仁

第82回日本血液学会学術集会  2020.10.10 

Assessment of optimal introduction ratio of CD3z-based artificial T cell activating molecule to TCR.

Sakai T, Terakura S, Okuno S, Miyao K, Hamana H, Kishi H, Nishida T, Murata M, Kiyoi H.

2020.10.10 

Comparison of drug sensitivity and resistance to FLT3 inhibitors in FLT3 mutated AML-PDX models

2020.10.10 

Upregulation of adhesion molecules associates with PDX-specific clonal expansion and R/R AML.

2020.10.10 

Phase I study of cord blood transplantation with intra-bone marrow injection of MSC.

Goto T, Murata M, Nishida T, Terakura S, Kamoshita S, Ishikawa Y, Ushijima Y, Adachi Y, Kato K, Hirakawa A, Nishiwaki S, Nishio N, Takahashi Y, Kodera Y, Matsushita T, Kiyoi H.

2020.10.10 

Optimization of antigen recognition in the development of anti-CD37 chimeric antigen receptor T cell

Okuno S, Adachi Y, Terakura S, Julamanee J, Sakai T, Nishida T, Murata M, Kiyoi H.

2020.10.10 

Efficacy of a novel anti-transferrin antibody, TSP-A74, in the treatment of AML.

中島　麻梨絵、石川　裕一、大平　悠太、鵜飼　由範、金　貞姫、川島　直実、牛島　洋子、松浦　正、清井　仁

第82回日本血液学会学術集会  2020.10.10 

Exosomes derived from cancer associated fibroblasts induce a resistance to histone deacetylase inhibitors in lymphoma.

加賀谷裕介、島田和之、久納俊祐、疋田智也、青木智広、坂本明彦、早川文彦、小根山千歳、清井仁.

第79回日本癌学会学術総会  2020.10.1 

遺伝子改変CD3z人工アダプター分子のTCRに対する至適遺伝子導入比率の検討

堺　寿保, 寺倉精太郎, 奥野真吾, 宮尾康太郎, 浜名　洋, 岸　裕幸, 西田徹也, 村田　誠, 清井　仁

第12回日本血液疾患免疫療法学会学術集会  2020.9.12 

間葉系幹細胞の骨髄内輸注を併用する臍帯血移植に関する臨床第I相試験

後藤辰徳, 村田　誠, 西田徹也, 寺倉精太郎, 鴨下園子, 石川裕一, 牛島洋子, 足立佳也, 加藤勝義, 平川晃弘, 西脇聡史, 西尾信博, 高橋義行, 小寺良尚, 松下　正, 清井　仁

第12回日本血液疾患免疫療法学会学術集会  2020.9.12 

Low-factor consumption and cost effectiveness for surgeries in hemophilia B patients with N9-GP International conference

International Society on Thrombosis and Haematosis 2020  2020.7.11 

ndothelial colony forming cells (ECFCs) 樹立法の標準化への試み

岡本修一、 鈴木伸明、 兼松毅、 鈴木敦夫、 大平晃也、 所真昼、 早川友梨、 田村彰吾、 早川文彦、 清井仁、 小嶋哲人、 松下正

第42回日本血栓止血学会  2020.6.20 

The Optimal Treatment Strategy for Adult Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Complete Remission in the Era of High-Intensity Chemotherapy International conference

Kako Shinichi, Hayakawa Fumihiko, Imai Kiyotoshi, Tanaka Junji, Mizuta Shuichi, Nishiwaki Satoshi, Kanamori Heiwa, Doki Noriko, Uchida Naoyuki, Ikegame Kazuhiro, Fukuda Takahiro, Ichinohe Tatsuo, Ota Shuichi, Tanaka Yoshinori, Murayama Tohru, Kurahashi Shingo, Sakura Toru, Usui Noriko, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Atsuta Yoshiko

American Society of Hematology Annual meeting  2019.11.13 

Phase I Study of Cord Blood Transplantation with Intra-Bone Marrow Injection of Mesenchymal Stem Cells International conference

Goto Tatsunori, Murata Makoto, Nishida Tetsuya, Terakura Seitaro, Kamoshita Sonoko, Ishikawa Yuichi, Ushijima Yoko, Adachi Yoshiya, Kato Katsuyoshi, Hirakawa Akihiro, Nishiwaki Satoshi, Nishio Nobuhiro, Takahashi Yoshiyuki, Kodera Yoshihisa, Matsushita Tadashi, Kiyoi Hitoshi

American Society of Hematology Annual meeting  2019.11.13 

Prospective Comparison of Azacitidine Treatment between 7-Days and 5-Days Schedules for Patients with Higher-Risk Myelodysplastic Syndromes; Results of Japan Adult Leukemia Study Group MDS212 Trial International conference

Kiguchi Toru, Sato Shinya, Usuki Kensuke, Ishiyama Ken, Ito Yoshikazu, Suzuki Takahiro, Taguchi Jun, Chiba Shigeru, Dobashi Nobuaki, Tomita Akihiro, Harada Hironori, Handa Hiroshi, Horiike Shigeo, Maeda Tomoya, Matsuda Mitsuhiro, Ichikawa Motoshi, Hata Tomoko, Honda Sumihisa, Iyama Satoshi, Suzushima Hitoshi, Moriuchi Yukiyoshi, Kurokawa Toshiro, Yamauchi Takahiro, Kiyoi Hitoshi, Naoe Tomoki, Miyazaki Yasushi

American Society of Hematology Annual meeting  2019.11.13 

Prospective Evaluation of Allogeneic HSCT at the First Remission for Younger Adults with FLT3-ITD Positive Acute Myeloid Leukemia: The JALSG AML209-FLT3-SCT Study International conference

Kawashima Naomi, Ishikawa Yuichi, Atsuta Yoshiko, Sawa Masashi, Ozawa Yukiyasu, Hayashi Masaki, Kohno Akio, Tomita Akihiro, Maeda Tomoya, Sakaida Emiko, Usuki Kensuke, Hagihara Maki, Kanamori Heiwa, Matsuoka Hiroshi, Kobayashi Miki, Asou Norio, Ohtake Shigeki, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Kiyoi Hitoshi

American Society of Hematology Annual meeting  2019.11.13 

Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells International conference

Tange Naoyuki, Hayakawa Fumihiko, Yasuda Takahiko, Yamamoto Hideyuki, Hirano Daiki, Tsuzuki Shinobu, Kiyoi Hitoshi

2019.11.13 

Guided Polarization of iPSC-Derived CD4SP Helper T Cells By CRISPR/Cas9-Based Genome-Editing International conference

Yano Hisashi, Shinohara Tokuyuki, Koga Keiko, Iriguchi Shoichi, Miyake Yasuyuki, Song Xuewei, Tada Megumi, Kassai Yoshiaki, Kiyoi Hitoshi, Kaneko Shin

American Society of Hematology Annual meeting  2019.11.13 

Development of Predictive Biomarker and Optimal Treatment Strategy with FLT3 Inhibitors in Acute Myeloid Leukemia International conference

Kim Jeong Hui, Harada Yasuhiko, Ishikawa Yuichi, Kawashima Naomi, Nakashima Marie, Ushijima Yoko, Nishiyama Takahiro, Goto Tatsunori, Fukushima Nobuaki, Kihara Rika, Kajiguchi Tomohiro, Watamoto Koichi, Kohno Akio, Kitamura Kunio, Ozawa Yukiyasu, Kiyoi Hitoshi

American Society of Hematology Annual meeting  2019.11.13 

Discovery of a Novel Dihydroorotate Dehydrogenase Inhibitor That Induces Differentiation and Overcomes Ara-C Resistance of Acute Myeloid Leukemia Cells International conference

Kitazawa Satoshi, Ishii Yukiko, Makita-Suzuki Keiko, Saito Koichi, Takayanagi Kensuke, Sugihara Hiromi, Matsuda Shun, Yamakawa Takayuki, Tsutsui Yasuhiro, Tanaka Tadashi, Hatta Tomohisa, Natsume Tohru, Kondo Toru, Ishikawa Yuichi, Hagiwara Shinji, Kiyoi Hitoshi

American Society of Hematology Annual meeting  2019.11.13 

Efficacy and Safety of Blinatumomab in Asian Adults with Relapsed/Refractory B-Precursor ALL International coauthorship International conference

Kobayashi Yukio, Oh Iekuni, Miyamoto Toshihiro, Lee Won-Sik, Iida Hiroatsu, Minami Hironobu, Maeda Yoshinobu, Jang Jun Ho, Yoon Sung-Soo, Yeh Su-Peng, Qui Tran, Morris Joan, Franklin Janet L., Chong Ka-Wing, Kiyoi Hitoshi

American Society of Hematology Annual meeting  2019.11.13 

FF-10101 Retains Potent Inhibitory Activities Against Resistant Mutations to FLT3 Inhibitors, Newly Identified in Random Mutagenesis Screens International conference

Ishikawa Yuichi, Saito Koichi, Kawashima Naomi, Morimoto Michie, Murao Hidetoshi, Terada Daisuke, Yamaura Takeshi, Hagiwara Shinji, Kiyoi Hitoshi

American Society of Hematology Annual meeting  2019.11.13 

Development of Predictive Biomarker and Optimal Treatment Strategy with FLT3 Inhibitors in Acute Myeloid Leukemia International conference

Kim, JH; Harada, Y; Ishikawa, Y; Kawashima, N; Nakashima, M; Ushijima, Y; Nishiyama, T; Goto, T; Fukushima, N; Kihara, R; Kajiguchi, T; Watamoto, K; Kohno, A; Kitamura, K; Ozawa, Y; Kiyoi, H

BLOOD  2019.11.13 

Prospective Evaluation of Prognostic Relevance of KIT Mutations in Core-Binding Factor Acute Myeloid Leukemia: Results from the JALSG CBF-AML209-KIT Study International conference

Kawashima Naomi, Ishikawa Yuichi, Atsuta Yoshiko, Sugiura Isamu, Sawa Masashi, Dobashi Nobuaki, Yokoyama Hisayuki, Doki Noriko, Tomita Akihiro, Kiguchi Toru, Koh Shiro, Kanamori Heiwa, Iriyama Noriyoshi, Kohno Akio, Moriuchi Yukiyoshi, Asada Noboru, Hirano Daiki, Togitani Kazuto, Sakura Toru, Hagihara Maki, Tomikawa Tatsuki, Yokoyama Yasuhisa, Asou Norio, Ohtake Shigeki, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Kiyoi Hitoshi

American Society of Hematology Annual meeting  2018.11.29 

Phase 2 Study of Blinatumomab in Japanese Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia (R/R ALL) International coauthorship International conference

Kobayashi Yukio, Zimmerman Zachary F., Oh Iekuni, Maeda Yoshinobu, Minami Hironobu, Miyamoto Toshihiro, Sakura Toru, Iida Hiroatsu, Chen Yuqi, Kiyoi Hitoshi

American Society of Hematology Annual meeting  2018.11.29