Updated on 2021/11/02

写真a

 
KIYOI, Hitoshi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Internal Medicine Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor

Degree 1

  1. Doctor of Medicine ( 1992.3   Nagoya University ) 

Research Interests 5

  1. Molecular target therapy

  2. Stem cell transplantation

  3. chemotherapy

  4. leukemia

  5. hematologic tumor

Research Areas 3

  1. Life Science / Hematology and medical oncology  / Hematological malignancy

  2. Life Science / Tumor diagnostics and therapeutics  / Molecular target therapy

  3. Life Science / General internal medicine  / Hematology

Current Research Project and SDGs 5

  1. Characterization of the biology of hematologic malignancies

  2. Development of the muleecularly targeted theray to hematological malignancies

  3. Chemotheray and Stem cell transplantation for the hematological malignancies

  4. Biological Significance of the FLT3 gene mutation

  5. 造血器腫瘍に対する免疫療法の開発

Research History 4

  1. Nagoya University   Graduate School of Medicine, Department of Hematology and Oncology   Professor

    2014.5

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    Country:Japan

  2. Nagoya University   Nagoya University Hospital Center for Postgraduate Clinical Training and Career Development   Director in General

    2017.4 - 2019.3

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    Country:Japan

  3. Nagoya University   Nagoya University Hospital

    2016.4 - 2019.3

  4. Nagoya University   Graduate School of Medicine Program in Integrated Medicine Internal Medicine   Associate professor

    2011.8 - 2014.4

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    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Medicine

    - 1992

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 1986

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    Country: Japan

Professional Memberships 8

  1. 日本血液学会   理事、評議員、プログラム企画委員、ガイドライン委員、学術・統計調査委員、国際委員、東海地方会代表

    2010.4

  2. 日本臨床腫瘍学会   協議員

    2008.4

  3. 日本内科学会   評議員

    2015.4

  4. 日本癌学会   評議員

    2012.10

  5. 日本造血細胞移植学会

  6. 日本輸血・細胞療法学会

  7. American Society of Hematology

  8. European Hematology Association

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Awards 8

  1. JCA CHAAO賞

    2020.10   日本癌学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. 日本白血病研究基金清水賞

    2016.11   公益信託 日本白血病研究基金  

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

  3. 上原記念生命科学財団 研究助成

    2015   上原記念生命科学財団  

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    Country:Japan

  4. 東京生化学研究会 研究助成

    2015   東京生化学研究会  

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    Country:Japan

  5. 小林がん学術振興会 先駆的研究賞

    2012   小林がん学術振興会  

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    Country:Japan

  6. 日本白血病研究基金 一般研究賞

    2000   日本白血病研究基金  

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    Country:Japan

  7. 武田科学振興財団 一般研究奨励賞

    1999   武田科学振興財団  

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    Country:Japan

  8. 上原記念生命科学財団 研究奨励賞

    1997   上原記念生命科学財団  

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    Country:Japan

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Papers 264

  1. A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations. Reviewed

    Yamaura T, Nakatani T, Uda K, Ogura H, Shin W, Kurokawa N, Saito K, Fujikawa N, Date T, Takasaki M, Terada D, Hirai A, Akashi A, Chen F, Adachi Y, Ishikawa Y, Hayakawa F, Hagiwara S, Naoe T, Kiyoi H.

    Blood     2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2017-05-786657

  2. Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma. Reviewed

    Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H.

    Leukemia.   Vol. 30 ( 7 ) page: 1568-79   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/leu.2016.67

  3. Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults. Reviewed

    Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T, Mano H.

    Nat Genet.   Vol. 48 ( 5 ) page: 569-74   2016.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ng.3535

  4. Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. Reviewed

    Kihara R, Nagata Y, Kiyoi H, Kato T, Yamamoto E, Suzuki K, Chen F, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Usui N, Kanamori H, Kiguchi T, Imai K, Uike N, Kimura F, Kitamura K, Nakaseko C, Onizuka M, Takeshita A, Ishida F, Suzushima H, Kato Y, Miwa H, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Naoe T.

    Leukemia   Vol. 28   page: 1586-1595   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

  5. Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation. Reviewed

    Yasuda T, Ueno T, Fukumura K, Yamato A, Ando M, Yamaguchi H, Soda M, Kawazu M, Sai E, Yamashita Y, Murata M, Kiyoi H, Naoe T, Mano H.

    Leukemia   Vol. 28   page: 426-428   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

  6. Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment. Reviewed

    Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T.

    Blood   Vol. 118   page: 1600-1609   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

  7. KW-2449, a novel multi-kinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Reviewed

    Shiotsu Y*, Kiyoi H*, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T.

    Blood   Vol. 114   page: 1607-1617   2009

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  8. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies Reviewed

    Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Saito K, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Saito H, Ueda R, Ohno R, and Naoe T.

    Blood   Vol. 97   page: 2434-2439   2001

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    Language:English   Publishing type:Research paper (scientific journal)  

  9. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Reviewed

    Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R.

    Blood   Vol. 93   page: 3074-3080   1999

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  10. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Reviewed

    Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H, Naoe T.

    Leukemia   Vol. 12   page: 1333-1337   1998

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  11. Allogeneic hematopoietic stem cell transplantation at the first remission for younger adults with FLT3-internal tandem duplication AML: The JALSG AML209-FLT3-SCT study. Reviewed International journal

    Kawashima N, Ishikawa Y, Atsuta Y, Sawa M, Ozawa Y, Hayashi M, Kohno A, Tomita A, Maeda T, Sakaida E, Usuki K, Hagihara M, Kanamori H, Matsuoka H, Kobayashi M, Asou N, Ohtake S, Matsumura I, Miyazaki Y, Naoe T, Kiyoi H, Japan Adult Leukemia Study Group (JALSG).

    Cancer science   Vol. 111 ( 7 ) page: 2472 - 2481   2020.7

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14448

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    PubMed

  12. Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial Reviewed International journal

    Shimada Kazuyuki, Yamaguchi Motoko, Atsuta Yoshiko, Matsue Kosei, Sato Keijiro, Kusumoto Shigeru, Nagai Hirokazu, Takizawa Jun, Fukuhara Noriko, Nagafuji Koji, Miyazaki Kana, Ohtsuka Eiichi, Okamoto Masataka, Sugita Yasumasa, Uchida Toshiki, Kayukawa Satoshi, Wake Atsushi, Ennishi Daisuke, Kondo Yukio, Izumi Tohru, Kin Yoshihiro, Tsukasaki Kunihiro, Hashimoto Daigo, Yuge Masaaki, Yanagisawa Atsumi, Kuwatsuka Yachiyo, Shimada Satoko, Masaki Yasufumi, Niitsu Nozomi, Kiyoi Hitoshi, Suzuki Ritsuro, Tokunaga Takashi, Nakamura Shigeo, Kinoshita Tomohiro

    LANCET ONCOLOGY   Vol. 21 ( 4 ) page: 593 - 602   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S1470-2045(20)30059-0

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  13. FLT3 mutations in acute myeloid leukemia: Therapeutic paradigm beyond inhibitor development Invited Reviewed International journal

    Kiyoi Hitoshi, Kawashima Naomi, Ishikawa Yuichi

    CANCER SCIENCE   Vol. 111 ( 2 ) page: 312 - 322   2020.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14274

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  14. Prospective evaluation of prognostic impact of KIT mutations on acute myeloid leukemia with RUNX1-RUNX1T1 and CBFB-MYH11 Reviewed International journal

    Ishikawa Yuichi, Kawashima Naomi, Atsuta Yoshiko, Sugiura Isamu, Sawa Masashi, Dobashi Nobuaki, Yokoyama Hisayuki, Doki Noriko, Tomita Akihiro, Kiguchi Toru, Koh Shiro, Kanamori Heiwa, Iriyama Noriyoshi, Kohno Akio, Moriuchi Yukiyoshi, Asada Noboru, Hirano Daiki, Togitani Kazuto, Sakura Toru, Hagihara Maki, Tomikawa Tatsuki, Yokoyama Yasuhisa, Asou Norio, Ohtake Shigeki, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Kiyoi Hitoshi

    BLOOD ADVANCES   Vol. 4 ( 1 ) page: 66 - 75   2020.1

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/bloodadvances.2019000709

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  15. Optimal treatment for Philadelphia-negative acute lymphoblastic leukemia in first remission in the era of high-intensity chemotherapy

    Kako Shinichi, Hayakawa Fumihiko, Imai Kiyotoshi, Tanaka Junji, Mizuta Shuichi, Nishiwaki Satoshi, Kanamori Heiwa, Mukae Junichi, Ozawa Yukiyasu, Kondo Tadakazu, Fukuda Takahiro, Ichinohe Tatsuo, Ota Shuichi, Tanaka Yoshinori, Murayama Tohru, Kurahashi Shingo, Sakura Toru, Usui Noriko, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Atsuta Yoshiko

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 114 ( 5 ) page: 608 - 619   2021.11

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  16. Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations. Reviewed International journal

    Yasuda T, Sanada M, Kawazu M, Kojima S, Tsuzuki S, Ueno H, Iwamoto E, Iijima-Yamashita Y, Yamada T, Kanamori T, Nishimura R, Kuwatsuka Y, Takada S, Tanaka M, Ota S, Dobashi N, Yamazaki E, Hirose A, Murayama T, Sumi M, Sato S, Tange N, Nakamura Y, Katsuoka Y, Sakaida E, Kawamata T, Iida H, Shiraishi Y, Nannya Y, Ogawa S, Taniwaki M, Asou N, Hatta Y, Kiyoi H, Matsumura I, Horibe K, Mano H, Naoe T, Miyazaki Y, Hayakawa F

    Blood     2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood.2021011921

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  17. Current progress and future perspectives of research on intravascular large B-cell lymphoma

    Shimada Kazuyuki, Kiyoi Hitoshi

    CANCER SCIENCE   Vol. 112 ( 10 ) page: 3953 - 3961   2021.10

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  18. Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival

    Julamanee Jakrawadee, Terakura Seitaro, Umemura Koji, Adachi Yoshitaka, Miyao Kotaro, Okuno Shingo, Takagi Erina, Sakai Toshiyasu, Koyama Daisuke, Goto Tatsunori, Hanajiri Ryo, Hudecek Michael, Steinberger Peter, Leitner Judith, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

    MOLECULAR THERAPY   Vol. 29 ( 9 ) page: 2677 - 2690   2021.9

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  19. Efficacy and safety of blinatumomab: Post hoc pooled analysis in Asian adults with relapsed/refractory B-cell precursor acute lymphoblastic leukemia

    Kobayashi Yukio, Oh Iekuni, Miyamoto Toshihiro, Lee Won-Sik, Iida Hiroatsu, Minami Hironobu, Maeda Yoshinobu, Jang Jun Ho, Yoon Sung-Soo, Yeh Su-Peng, Tran Qui, Morris Joan, Franklin Janet, Kiyoi Hitoshi

    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY     2021.6

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  20. Spacer Length Modification Facilitates Discrimination between Normal and Neoplastic Cells and Provides Clinically Relevant CD37 CAR T Cells Reviewed International journal

    Okuno Shingo, Adachi Yoshitaka, Terakura Seitaro, Julamanee Jakrawadee, Sakai Toshiyasu, Umemura Koji, Miyao Kotaro, Goto Tatsunori, Murase Atsushi, Shimada Kazuyuki, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

    JOURNAL OF IMMUNOLOGY   Vol. 206 ( 12 ) page: 2862 - 2874   2021.6

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.2000768

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  21. Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma

    Kunou Shunsuke, Shimada Kazuyuki, Takai Mika, Sakamoto Akihiko, Aoki Tomohiro, Hikita Tomoya, Kagaya Yusuke, Iwamoto Eisuke, Sanada Masashi, Shimada Satoko, Hayakawa Fumihiko, Oneyama Chitose, Kiyoi Hitoshi

    ONCOGENE   Vol. 40 ( 23 ) page: 3989 - 4003   2021.6

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  22. A Case Report of Bursitis, Bacteremia, and Disseminated Infection of Mycobacteroides (Mycobacterium) abscessus subsp. massiliense. Reviewed International journal

    Oka K, Morioka H, Eguchi M, Sato Y, Tetsuka N, Iguchi M, Kanematsu T, Fukano H, Hoshino Y, Kiyoi H, Yagi T

    Internal medicine (Tokyo, Japan)     2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.6189-20

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  23. Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma

    Shimada Kazuyuki, Yoshida Kenichi, Suzuki Yasuhiro, Iriyama Chisako, Inoue Yoshikage, Sanada Masashi, Kataoka Keisuke, Yuge Masaaki, Takagi Yusuke, Kusumoto Shigeru, Masaki Yasufumi, Ito Takahiko, Inagaki Yuichiro, Okamoto Akinao, Kuwatsuka Yachiyo, Nakatochi Masahiro, Shimada Satoko, Miyoshi Hiroaki, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Shiozawa Yusuke, Nannya Yasuhito, Okabe Asako, Kohno Kei, Atsuta Yoshiko, Ohshima Koichi, Nakamura Shigeo, Ogawa Seishi, Tomita Akihiro, Kiyoi Hitoshi

    BLOOD   Vol. 137 ( 11 ) page: 1491 - 1502   2021.3

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  24. Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group Reviewed International journal

    Saito Takeshi, Hatta Yoshihiro, Hayakawa Fumihiko, Takahashi Tsutomu, Hagihara Maki, Iida Hiroatsu, Minauchi Koichiro, Yamazaki Etsuko, Sugiura Isamu, Murayama Tohru, Sakura Toru, Mori Naoki, Imai Kiyotoshi, Yahagi Yuichi, Atsuta Yoshiko, Saito Akiko Moriya, Hirakawa Akihiro, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 113 ( 3 ) page: 395 - 403   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-020-03032-3

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  25. Machine learning-aided risk stratification in Philadelphia chromosome-positive acute lymphoblastic leukemia

    Nishiwaki Satoshi, Sugiura Isamu, Koyama Daisuke, Ozawa Yukiyasu, Osaki Masahide, Ishikawa Yuichi, Kiyoi Hitoshi

    BIOMARKER RESEARCH   Vol. 9 ( 1 ) page: 13   2021.2

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  26. Impact of variation in reagent combinations for one-stage clotting assay on assay discrepancy in nonsevere haemophilia A Reviewed International journal

    Suzuki Atsuo, Suzuki Nobuaki, Kanematsu Takeshi, Okamoto Shuichi, Tamura Shogo, Kikuchi Ryosuke, Katsumi Akira, Kiyoi Hitoshi, Kojima Tetsuhito, Matsushita Tadashi

    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY   Vol. 43 ( 1 ) page: 131 - 138   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ijlh.13335

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  27. Myh9 R702C is associated with erythroid abnormality with splenomegaly in mice

    Kanematsu Takeshi, Suzuki Nobuaki, Tamura Shogo, Suzuki Atsuo, Ishikawa Yuichi, Katsumi Akira, Kiyoi Hitoshi, Saito Hidehiko, Kunishima Shinji, Kojima Tetsuhito, Matsushita Tadashi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 1 ) page: 75 - 86   2021.2

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  28. A case of reexpansion pulmonary edema and acute pulmonary thromboembolism associated with diffuse large B-cell lymphoma treated with venovenous extracorporeal membrane oxygenation. Reviewed International journal

    Kazama S, Hiraiwa H, Kimura Y, Ozaki R, Shibata N, Arao Y, Oishi H, Kato H, Kuwayama T, Yamaguchi S, Kondo T, Furusawa K, Morimoto R, Okumura T, Bando YK, Sato T, Shimada K, Kiyoi H, Nakamura G, Yasuda Y, Kasugai D, Ogawa H, Higashi M, Yamamoto T, Jingushi N, Ozaki M, Numaguchi A, Goto Y, Matsuda N, Murohara T

    Journal of cardiology cases   Vol. 23 ( 1 ) page: 53 - 56   2021.1

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    DOI: 10.1016/j.jccase.2020.08.013

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  29. Phase I clinical trial of intra-bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation Reviewed International journal

    Goto Tatsunori, Murata Makoto, Nishida Tetsuya, Terakura Seitaro, Kamoshita Sonoko, Ishikawa Yuichi, Ushijima Yoko, Adachi Yoshiya, Suzuki Satoshi, Kato Katsuyoshi, Hirakawa Akihiro, Nishiwaki Satoshi, Nishio Nobuhiro, Takahashi Yoshiyuki, Kodera Yoshihisa, Matsushita Tadashi, Kiyoi Hitoshi

    STEM CELLS TRANSLATIONAL MEDICINE     2020.12

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/sctm.20-0381

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  30. Predictors of early death, serious hemorrhage, and differentiation syndrome in Japanese patients with acute promyelocytic leukemia Reviewed International journal

    Minamiguchi Hitoshi, Fujita Hiroyuki, Atsuta Yoshiko, Asou Norio, Sakura Toru, Ueda Yasunori, Sawa Masashi, Dobashi Nobuaki, Taniguchi Yasuhiro, Suzuki Rikio, Uchino Yoshihito, Tomita Akihiro, Tamaki Shigehisa, Hagihara Maki, Fujimaki Katsumichi, Yanada Masamitsu, Maeda Yoshinobu, Iwanaga Masako, Usui Noriko, Kobayashi Yukio, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Takeshita Akihiro

    ANNALS OF HEMATOLOGY   Vol. 99 ( 12 ) page: 2787 - 2800   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00277-020-04245-6

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  31. Multi-Lineage BCR-ABL Expression in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Is Associated With Improved Prognosis but No Specific Molecular Features Reviewed International journal

    Nishiwaki Satoshi, Kim Jeong Hui, Ito Masafumi, Maeda Matsuyoshi, Okuno Yusuke, Koyama Daisuke, Ozawa Yukiyasu, Gunji Masaharu, Osaki Masahide, Kitamura Kunio, Ushijima Yoko, Ishikawa Yuichi, Miyamura Koichi, Sugiura Isamu, Kiyoi Hitoshi

    FRONTIERS IN ONCOLOGY   Vol. 10   2020.10

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fonc.2020.586567

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  32. Phase I study of duvelisib in Japanese patients with relapsed or refractory lymphoma Reviewed International journal

    Izutsu Koji, Kato Koji, Kiyoi Hitoshi, Yamamoto Go, Shimada Kazuyuki, Akashi Koichi

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 112 ( 4 ) page: 504 - 509   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-020-02929-3

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  33. Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity Reviewed International coauthorship International journal

    Sakai Toshiyasu, Terakura Seitaro, Miyao Kotaro, Okuno Shingo, Adachi Yoshitaka, Umemura Koji, Julamanee Jakrawadee, Watanabe Keisuke, Hamana Hiroshi, Kishi Hiroyuki, Leitner Judith, Steinberger Peter, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

    MOLECULAR THERAPY-ONCOLYTICS   Vol. 18   page: 613 - 622   2020.9

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.omto.2020.08.014

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  34. Real-world management of infection during chemotherapy for acute leukemia in Japan: from the results of a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group Reviewed International journal

    Kimura Shun-ichi, Fujita Hanako, Handa Hiroshi, Hiramoto Nobuhiro, Hosono Naoko, Minamiguchi Hitoshi, Takahashi Tsutomu, Kato Hideaki, Ono Takaaki, Kanda Yoshinobu, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 112 ( 3 ) page: 409 - 417   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-020-02921-x

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  35. Clinical utility of target capture-based panel sequencing in hematological malignancies: A multicenter feasibility study Reviewed International journal

    Yasuda Takahiko, Sanada Masashi, Nishijima Dai, Kanamori Takashi, Iijima Yuka, Hattori Hiroyoshi, Saito Akiko, Miyoshi Hiroaki, Ishikawa Yuichi, Asou Norio, Usuki Kensuke, Hirabayashi Shinsuke, Kato Motohiro, Ri Masaki, Handa Hiroshi, Ishida Tadao, Shibayama Hirohiko, Abe Masahiro, Iriyama Chisako, Karube Kennosuke, Nishikori Momoko, Ohshima Koichi, Kataoka Keisuke, Yoshida Kenichi, Shiraishi Yuichi, Goto Hiroaki, Adachi Souichi, Kobayashi Ryoji, Kiyoi Hitoshi, Miyazaki Yasushi, Ogawa Seishi, Kurahashi Hiroki, Yokoyama Hisayuki, Manabe Atsushi, Iida Shinsuke, Tomita Akihiro, Horibe Keizo

    CANCER SCIENCE   Vol. 111 ( 9 ) page: 3367 - 3378   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14552

    Web of Science

  36. Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia (vol 111, pg 1314, 2020) Reviewed International coauthorship International journal

    Kiyoi Hitoshi, Morris Joan D., Oh Iekuni, Maeda Yoshinobu, Minami Hironobu, Miyamoto Toshihiro, Sakura Toru, Iida Hiroatsu, Tuglus Catherine A., Chen Yuqi, Dos Santos Cedric, Kalabus James, Anderson Abraham, Hata Tomoko, Nakashima Yasuhiro, Kobayashi Yukio

    CANCER SCIENCE   Vol. 111 ( 8 ) page: 3082 - 3082   2020.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14598

    Web of Science

  37. Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells. Reviewed International journal

    Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie   Vol. 128   page: 110330   2020.8

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    DOI: 10.1016/j.biopha.2020.110330

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    PubMed

  38. Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. Reviewed International journal

    Tsuzuki S, Yasuda T, Kojima S, Kawazu M, Akahane K, Inukai T, Imaizumi M, Morishita T, Miyamura K, Ueno T, Karnan S, Ota A, Hyodo T, Konishi H, Sanada M, Nagai H, Horibe K, Tomita A, Suzuki K, Muramatsu H, Takahashi Y, Miyazaki Y, Matsumura I, Kiyoi H, Hosokawa Y, Mano H, Hayakawa F

    Blood cancer discovery   Vol. 1 ( 1 ) page: 82 - 95   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/2643-3230.BCD-19-0080

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  39. Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies Reviewed International journal

    Mizuno Kazuyuki, Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Kawashima Hiroki, Inukai Yosuke, Toyoda Hidenori, Yokota Kenji, Hase Tetsunari, Maeda Osamu, Kiyoi Hitoshi, Nagino Masato, Hibi Hideharu, Kodera Yasuhiro, Fujimoto Yasushi, Sone Michihiko, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY   Vol. 55 ( 6 ) page: 653 - 661   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00535-020-01677-9

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  40. Impact of CD56 Continuously Recognizable as Prognostic Value of Acute Promyelocytic Leukemia: Results of Multivariate Analyses in the Japan Adult Leukemia Study Group (JALSG)-APL204 Study and a Review of the Literature. Reviewed

    Takeshita A, Asou N, Atsuta Y, Furumaki H, Sakura T, Ueda Y, Sawa M, Dobashi N, Taniguchi Y, Suzuki R, Nakagawa M, Tamaki S, Hagihara M, Fujimaki K, Minamiguchi H, Fujita H, Yanada M, Maeda Y, Usui N, Kobayashi Y, Kiyoi H, Ohtake S, Matsumura I, Naoe T, Miyazaki Y, Group TJALS

    Cancers   Vol. 12 ( 6 )   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers12061444

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  41. JSH Practical Guidelines for Hematological Malignancies, 2018: I. Leukemia-1. Acute myeloid leukemia (AML) Invited Reviewed International journal

    Kiyoi Hitoshi, Yamaguchi Hiroki, Maeda Yoshinobu, Yamauchi Takahiro

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 111 ( 5 ) page: 595 - 613   2020.5

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    DOI: 10.1007/s12185-020-02856-3

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  42. Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia Reviewed International coauthorship International journal

    Kiyoi Hitoshi, Morris Joan D., Oh Lekuni, Maeda Yoshinobu, Minami Hironobu, Miyamoto Toshihiro, Sakura Toru, Iida Hiroatsu, Tuglus Catherine A., Chen Yuqi, Dos Santos Cedric, Kalabus James, Anderson Abraham, Hata Tomoko, Nakashima Yasuhiro, Kobayashi Yukio

    CANCER SCIENCE   Vol. 111 ( 4 ) page: 1314 - 1323   2020.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14322

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    PubMed

  43. Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy Reviewed International journal

    Ogawa Mika, Suzuki Nobuaki, Takahashi Nobunori, Tamura Shogo, Suzuki Atsuo, Suzuki Sachiko, Hattori Yuua, Kakihara Misaki, Kanematsu Takeshi, Kojima Toshihisa, Katsumi Akira, Hayakawa Fumihiko, Kojima Tetsuhito, Ishiguro Naoki, Kiyoi Hitoshi, Matsushita Tadashi

    THROMBOSIS RESEARCH   Vol. 188   page: 103 - 105   2020.4

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    DOI: 10.1016/j.thromres.2020.01.003

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  44. Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study. Reviewed International journal

    Okada N, Iwama S, Okuji T, Kobayashi T, Yasuda Y, Wada E, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Hase T, Morise M, Kanda M, Yokota K, Hashimoto N, Ando M, Fujimoto Y, Nagino M, Kodera Y, Fujishiro M, Hibi H, Sone M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H

    British journal of cancer   Vol. 122 ( 6 ) page: 771 - 777   2020.3

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    DOI: 10.1038/s41416-020-0736-7

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  45. 悪性リンパ腫診療の進歩とピットフォール Invited

    島田和之、清井仁

    日本内科学会雑誌   Vol. 109 ( 3 ) page: 574 - 578   2020.3

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    Authorship:Last author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  46. Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation. Reviewed International journal

    Kamoshita S, Murata M, Koyama D, Julamanee J, Okuno S, Takagi E, Miyao K, Goto T, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H

    International journal of hematology   Vol. 111 ( 1 ) page: 112 - 119   2020.1

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    DOI: 10.1007/s12185-019-02739-2

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  47. Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia Reviewed International journal

    Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 59 ( 5 ) page: 683 - 687   2020

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    DOI: 10.2169/internalmedicine.3775-19

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  48. Allogeneic Hematopoietic Stem Cell Transplantation for Post-essential Thrombocythemia and Post-polycythemia Vera Myelofibrosis Reviewed International journal

    Murata Makoto, Suzuki Ritsuro, Nishida Tetsuya, Shirane Shuichi, Shimazu Yutaka, Minami Yosuke, Mori Takehiko, Doki Noriko, Kanda Yoshinobu, Uchida Naoyuki, Tanaka Masatsugu, Ishikawa Jun, Togitani Kazuto, Fukuda Takahiro, Ichinohe Tatsuo, Atsuta Yoshiko, Nagamura-Inoue Tokiko, Kiyoi Hitoshi

    INTERNAL MEDICINE   Vol. 59 ( 16 ) page: 1947 - 1956   2020

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    DOI: 10.2169/internalmedicine.4375-19

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  49. Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors.

    Okamoto S, Suzuki N, Suzuki A, Suzuki S, Tamura S, Suzuki M, Takahashi N, Kojima T, Kanematsu T, Kojima T, Kiyoi H, Ishiguro N, Matsushita T

    TH open : companion journal to thrombosis and haemostasis   Vol. 3 ( 4 ) page: e364-e366   2019.10

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    DOI: 10.1055/s-0039-3401001

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  50. ZNF384-fusion proteins have high affinity for the transcriptional coactivator EP300 and aberrant transcriptional activities. Reviewed International journal

    Yamamoto H, Hayakawa F, Yasuda T, Odaira K, Minamikawa Y, Tange N, Hirano D, Kojima Y, Morishita T, Tsuzuki S, Naoe T, Kiyoi H

    FEBS letters   Vol. 593 ( 16 ) page: 2151 - 2161   2019.8

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/1873-3468.13506

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  51. Exome analysis of treatment-related AML after APL suggests secondary evolution. Reviewed International coauthorship International journal

    Wang T, Jacoby MA, Duncavage EJ, Miller CA, Heath S, Rahme R, Fenaux P, Ades L, Renneville A, Cassinat B, Takeshita A, Asou N, Miyazaki Y, Kiyoi H, Ravandi F, Westervelt P, Wartman LD, Welch JS

    British journal of haematology   Vol. 185 ( 5 ) page: 984 - 987   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/bjh.15681

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  52. Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity. Reviewed

    Hirano D, Hayakawa F, Yasuda T, Tange N, Yamamoto H, Kojima Y, Morishita T, Imoto N, Tsuzuki S, Mano H, Naoe T, Kiyoi H

    Oncogene   Vol. 38 ( 13 ) page: 2263 - 2274   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41388-018-0573-9

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  53. Defective Epstein-Barr virus in chronic active infection and haematological malignancy. Reviewed

    Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H

    Nat Microbiol.   Vol. 4 ( 3 ) page: 404 - 413   2019.3

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    DOI: 10.1038/s41564-018-0334-0

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  54. Quantitative Assessment of T Cell Clonotypes in Human Acute Graft-versus-Host Disease Tissues. Reviewed

    Koyama D, Murata M, Hanajiri R, Akashi T, Okuno S, Kamoshita S, Julamanee J, Takagi E, Miyao K, Sakemura R, Goto T, Terakura S, Nishida T, Kiyoi H

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   Vol. 25 ( 3 ) page: 417 - 423   2019.3

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    DOI: 10.1016/j.bbmt.2018.10.012

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  55. Tamibarotene maintenance improved relapse-free survival of acute promyelocytic leukemia: a final result of prospective, randomized, JALSG-APL204 study. Reviewed

    Takeshita A, Asou N, Atsuta Y, Sakura T, Ueda Y, Sawa M, Dobashi N, Taniguchi Y, Suzuki R, Nakagawa M, Tamaki S, Hagihara M, Fujimaki K, Furumaki H, Obata Y, Fujita H, Yanada M, Maeda Y, Usui N, Kobayashi Y, Kiyoi H, Ohtake S, Matsumura I, Naoe T, Miyazaki Y, and the Japanese Adult Leukemia Study Group.

    Leukemia   Vol. 33 ( 2 ) page: 358 - 370   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41375-018-0233-7

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  56. Clinical significance of ASXL2 and ZBTB7A mutations and C-terminally truncated RUNX1-RUNX1T1 expression in AML patients with t(8;21) enrolled in the JALSG AML201 study.

    Kawashima N, Akashi A, Nagata Y, Kihara R, Ishikawa Y, Asou N, Ohtake S, Miyawaki S, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kitamura K, Sakaida E, Takeshita A, Suzushima H, Naoe T, Matsumura I, Miyazaki Y, Ogawa S, Kiyoi H, Japan Adult Leukemia Study Group (JALSG).

    Annals of hematology   Vol. 98 ( 1 ) page: 83 - 91   2019.1

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    DOI: 10.1007/s00277-018-3492-5

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  57. [Successful treatment of pre-engraftment disseminated fusariosis with high-dose liposomal amphotericin B in a cord blood transplant recipient]. Reviewed

    Harada Y, Murata M, Matsumoto A, Kato D, Yagi T, Yaguchi T, Yoshikawa T, Takeichi T, Akiyama M, Yamaguchi Y, Koyama D, Terakura S, Nishida T, Kiyoi H

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 60 ( 12 ) page: 1641 - 1646   2019

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    Authorship:Last author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11406/rinketsu.60.1641

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  58. [Acute myeloid leukemia: AML]. Invited

    Kiyoi H

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 60 ( 3 ) page: 224 - 225   2019

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    DOI: 10.11406/rinketsu.60.224

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  59. Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Reviewed

    Proceedings of the National Academy of Sciences of the United States of America     2018.11

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    DOI: 10.1073/pnas.1814397115

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  60. Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells. Reviewed

    Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H

    Cancer science     2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13873

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  61. Final analysis of the JALSG Ph+ALL202 study: tyrosine kinase inhibitor-combined chemotherapy for Ph plus ALL Reviewed

    Hatta Yoshihiro, Mizuta Shuichi, Matsuo Keitaro, Ohtake Shigeki, Iwanaga Masako, Sugiura Isamu, Doki Noriko, Kanamori Heiwa, Ueda Yasunori, Yoshida Chikamasa, Dobashi Nobuaki, Maeda Tomoya, Yujiri Toshiaki, Monma Fumihiko, Ito Yoshikazu, Hayakawa Fumihiko, Takeuchi Jin, Kiyoi Hitoshi, Miyazaki Yasushi, Naoe Tomoki

    ANNALS OF HEMATOLOGY   Vol. 97 ( 9 ) page: 1535 - 1545   2018.9

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    DOI: 10.1007/s00277-018-3323-8

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  62. Prognostic Analysis According to the 2017 ELN Risk Stratification by Genetics in Adult Acute Myeloid Leukemia Patients Treated in The Japan Adult Leukemia Study Group (JALSG) AML201 study Reviewed

    Harada Yasuhiko, Nagata Yasunobu, Kihara Rika, Ishikawa Yuichi, Asou Norio, Ohtake Shigeki, Miyawaki Shuichi, Sakura Toru, Ozawa Yukiyasu, Usui Noriko, Kanamori Heiwa, Ito Yoshikazu, Imai Kiyotoshi, Suehiro Youko, Kobayashi Shinichi, Kitamura Kunio, Sakaida Emiko, Onizuka Makoto, Takeshita Akihiro, Ishida Fumihiro, Suzushima Hitoshi, Ishizawa Kenichi, Naoe Tomoki, Matsumura Itaru, Miyazaki Yasushi, Ogawa Seishi, Kiyoi Hitoshi

    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA   Vol. 18   page: S196-S196   2018.9

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  63. Impact of hospital length of stay on the risk of readmission and overall survival after allogeneic stem cell transplantation Reviewed

    Seto Aika, Atsuta Yoshiko, Kawashima Naomi, Ozawa Yukiyasu, Miyamura Koichi, Kiyoi Hitoshi

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 108 ( 3 ) page: 290 - 297   2018.9

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    DOI: 10.1007/s12185-018-2477-4

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  64. Biology and management of primary effusion lymphoma. Reviewed

    Shimada K, Hayakawa F, Kiyoi H

    Blood     2018.8

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    DOI: 10.1182/blood-2018-03-791426

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  65. Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response Reviewed

    Ueda Norihiro, Uemura Yasushi, Zhang Rong, Kitayama Shuichi, Iriguchi Shoichi, Kawai Yohei, Yasui Yutaka, Tatsumi Minako, Ueda Tatsuki, Liu Tian-Yi, Mizoro Yasutaka, Okada Chihiro, Watanabe Akira, Nakanishi Mahito, Senju Satoru, Nishimura Yasuharu, Kuzushima Kiyotaka, Kiyoi Hitoshi, Naoe Tomoki, Kaneko Shin

    STEM CELL REPORTS   Vol. 10 ( 6 ) page: 1935 - 1946   2018.6

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    DOI: 10.1016/j.stemcr.2018.04.025

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  66. Infectious complications in adults undergoing intensive chemotherapy for acute myeloid leukemia in 2001-2005 using the Japan Adult Leukemia Study Group AML201 protocols.

    Kato H, Fujita H, Akiyama N, Kimura SI, Hiramoto N, Hosono N, Takahashi T, Shigeno K, Minamiguchi H, Miyatake J, Handa H, Kanda Y, Yoshida M, Miyawaki S, Ohtake S, Naoe T, Kiyoi H, Matsumura I, Miyazaki Y, Japan Adult Leukemia Study Group.

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     2018.6

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    DOI: 10.1007/s00520-018-4292-0

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  67. Introduction of Genetically Modified CD3 zeta Improves Proliferation and Persistence of Antigen-Specific CTLs Reviewed

    Miyao Kotaro, Terakura Seitaro, Okuno Shingo, Julamanee Jakrawadee, Watanabe Keisuke, Hamana Hiroshi, Kishi Hiroyuki, Sakemura Reona, Koyama Daisuke, Goto Tatsunori, Nishida Tetsuya, Murata Makoto, Kiyoi Hitoshi

    CANCER IMMUNOLOGY RESEARCH   Vol. 6 ( 6 ) page: 733 - 744   2018.6

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    DOI: 10.1158/2326-6066.CIR-17-0538

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  68. Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia. Reviewed

    Tanaka Y, Kawazu M, Yasuda T, Tamura M, Hayakawa F, Kojima S, Ueno T, Kiyoi H, Naoe T, Mano H

    Haematologica     2018.5

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    DOI: 10.3324/haematol.2017.183152

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  69. Mutation analysis of therapy-related myeloid neoplasms Reviewed

    Nishiyama Takahiro, Ishikawa Yuichi, Kawashima Naomi, Akashi Akimi, Adachi Yoshiya, Hattori Hikaru, Ushijima Yoko, Kiyoi Hitoshi

    CANCER GENETICS   Vol. 222   page: 38 - 45   2018.4

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    DOI: 10.1016/j.cancergen.2018.02.006

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  70. Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol Reviewed

    Goto Tatsunori, Murata Makoto, Terakura Seitaro, Nishida Tetsuya, Adachi Yoshiya, Ushijima Yoko, Shimada Kazuyuki, Ishikawa Yuichi, Hayakawa Fumihiko, Nishio Nobuhiro, Nishiwaki Satoshi, Hirakawa Akihiro, Kato Katsuyoshi, Takahashi Yoshiyuki, Kiyoi Hitoshi

    MEDICINE   Vol. 97 ( 17 ) page: e0449   2018.4

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    DOI: 10.1097/MD.0000000000010449

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  71. Analysis of the oligomeric states of nucleophosmin using size exclusion chromatography Reviewed

    Sakashita Gyosuke, Kiyoi Hitoshi, Naoe Tomoki, Urano Takeshi

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 4008   2018.3

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    DOI: 10.1038/s41598-018-22359-w

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  72. Clinical impact of underweight status at diagnosis on elderly patients with acute myeloid leukemia: a retrospective study of JALSG GML200. Reviewed

    Harada K, Doki N, Miyazaki Y, Wakita A, Ohtake S, Takada S, Komatsu H, Kubo K, Takeshita A, Adachi Y, Kiyoi H, Yamaguchi T, Yoshida M, Naoe T, Ohashi K

    Annals of hematology     2018.3

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    DOI: 10.1007/s00277-018-3281-1

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  73. Prognostic analysis according to the 2017 ELN risk stratification by genetics in adult acute myeloid leukemia patients treated in the Japan Adult Leukemia Study Group (JALSG) AML201 study. Reviewed

    Harada Y, Nagata Y, Kihara R, Ishikawa Y, Asou N, Ohtake S, Miyawaki S, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Onizuka M, Takeshita A, Ishida F, Suzushima H, Ishizawa K, Naoe T, Matsumura I, Miyazaki Y, Ogawa S, Kiyoi H, Japan Adult Leukemia Study Group JALSG.

    Leukemia research   Vol. 66   page: 20-27   2018.3

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    DOI: 10.1016/j.leukres.2018.01.008

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  74. High Incidence of Extensive Chronic Gvhd in Patients with the REG3A Rs7588571 Non-GG Genotype Reviewed

    Murata Makoto, Koyama Daisuke, Hanajiri Ryo, Okuno Shingo, Kamoshita Sonoko, Julamanee Jakrawadee, Takagi Erina, Hirano Daiki, Miyao Kotaro, Sakemura Reona, Goto Tatsunori, Hayakawa Fumihiko, Seto Aika, Ozawa Yukiyasu, Miyamura Koichi, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi

    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   Vol. 24 ( 3 ) page: S192-S193   2018.3

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  75. Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study Reviewed

    Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

    JOURNAL OF THE ENDOCRINE SOCIETY   Vol. 2 ( 3 ) page: 241 - 251   2018.3

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    DOI: 10.1210/js.2017-00432

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  76. Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia. Reviewed

    Kamijo R, Itonaga H, Kihara R, Nagata Y, Hata T, Asou N, Ohtake S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Naoe T, Kiyoi H, Miyazaki Y

    Leukemia research   Vol. 65   page: 34-41   2018.2

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    DOI: 10.1016/j.leukres.2017.12.006

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  77. Intrabone single unit cord blood transplantation for hematological malignancies Reviewed

    Murata Makoto, Maeda Yoshinobu, Masuko Masayoshi, Fukuhara Noriko, Nishida Tetsuya, Terakura Seitaro, Ishikawa Yuichi, Tanimoto Mitsune, Shibasaki Yasuhiko, Suzuki Ritsuro, Kodera Yoshihisa, Kiyoi Hitoshi, Naoe Tomoki

    CANCER SCIENCE   Vol. 109   page: 757-757   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  78. BCR-ABL-specific CD4<sup>+</sup> T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells. Reviewed International journal

    Ueda N, Zhang R, Tatsumi M, Liu TY, Kitayama S, Yasui Y, Sugai S, Iwama T, Senju S, Okada S, Nakatsura T, Kuzushima K, Kiyoi H, Naoe T, Kaneko S, Uemura Y

    Cellular & molecular immunology   Vol. 15 ( 1 ) page: 15 - 26   2018.1

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    DOI: 10.1038/cmi.2016.7

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    PubMed

  79. Underweight status at diagnosis is associated with poorer outcomes in adult patients with acute myeloid leukemia: a retrospective study of JALSG AML 201 Reviewed

    Harada Kaito, Doki Noriko, Hagino Takeshi, Miyawaki Shuichi, Ohtake Shigeki, Kiyoi Hitoshi, Miyazaki Yasushi, Fujita Hiroyuki, Usui Noriko, Okumura Hirokazu, Miyamura Koichi, Nakaseko Chiaki, Fujieda Atsushi, Nagai Tadashi, Yamane Takahisa, Sakamaki Hisashi, Ohnishi Kazunori, Naoe Tomoki, Ohno Ryuzo, Ohashi Kazuteru

    ANNALS OF HEMATOLOGY   Vol. 97 ( 1 ) page: 73 - 81   2018.1

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    DOI: 10.1007/s00277-017-3156-x

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  80. Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia. Reviewed

    Hattori H, Ishikawa Y, Kawashima N, Akashi A, Yamaguchi Y, Harada Y, Hirano D, Adachi Y, Miyao K, Ushijima Y, Terakura S, Nishida T, Matsushita T, Kiyoi H

    PloS one   Vol. 13 ( 10 ) page: e0204850   2018

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    DOI: 10.1371/journal.pone.0204850

    PubMed

  81. Underweight status at diagnosis is associated with poorer outcomes in adult patients with acute myeloid leukemia: a retrospective study of JALSG AML 201. Reviewed

    Harada K, Doki N, Hagino T, Miyawaki S, Ohtake S, Kiyoi H, Miyazaki Y, Fujita H, Usui N, Okumura H, Miyamura K, Nakaseko C, Fujieda A, Nagai T, Yamane T, Sakamaki H, Ohnishi K, Naoe T, Ohno R, Ohashi K

    Ann Hematol.     2017.12

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    DOI: 10.1007/s00277-017-3156-x.

  82. Efficacy and safety of autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia: A study protocol for a multicenter exploratory prospective study (Auto-Ph17 study)

    Nishiwaki Satoshi, Sugiura Isamu, Miyata Yasuhiko, Saito Shigeki, Sawa Masashi, Nishida Tetsuya, Miyamura Koichi, Kuwatsuka Yachiyo, Kohno Akio, Yuge Masaaki, Kasai Masanobu, Iida Hiroatsu, Kurahashi Shingo, Osaki Masahide, Goto Tatsunori, Terakura Seitaro, Murata Makoto, Nishikawa Hiroyoshi, Kiyoi Hitoshi

    MEDICINE   Vol. 96 ( 52 ) page: e9568   2017.12

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    DOI: 10.1097/MD.0000000000009568

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    PubMed

  83. Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome. Reviewed

    Shirahata-Adachi M, Iriyama C, Tomita A, Suzuki Y, Shimada K, Kiyoi H.

    Leuk Res   Vol. 63   page: 90-97   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.leukres.2017.10.015

  84. Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia. Reviewed

    Kuwatsuka Y, Tomizawa D, Kihara R, Nagata Y, Shiba N, Iijima-Yamashita Y, Shimada A, Deguchi T, Miyachi H, Tawa A, Taga T, Kinoshita A, Nakayama H, Kiyokawa N, Saito AM, Koh K, Goto H, Kosaka Y, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Ogawa S, Naoe T, Hayashi Y, Horibe K, Manabe A, Mizutani S, Adachi S, Kiyoi H.

    Int J Hematol     2017.10

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    DOI: 10.1007/s12185-017-2340-z

  85. Identification of volasertib-resistant mechanism and evaluation of combination effects with volasertib and other agents on acute myeloid leukemia. Reviewed

    Adachi Y, Ishikawa Y, Kiyoi H.

    Oncotarget   Vol. 8   page: 78452-78465   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.19632

  86. A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study). Reviewed

    Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Hanaoka N, Nakakuma H, Hasegawa D, Manabe A, Fujishima N, Fujii N, Tanimoto M, Morita Y, Matsuda A, Fujieda A, Katayama N, Ohashi H, Nagai H, Terada Y, Hino M, Sato K, Obara N, Chiba S, Usuki K, Ohta M, Imataki O, Uemura M, Takaku T, Komatsu N, Kitanaka A, Shimoda K, Watanabe K, Tohyama K, Takaori-Kondo A, Harigae H, Arai S, Miyazaki Y, Ozawa K, Kurokawa M; for National Research Group on Idiopathic Bone Marrow Failure Syndromes.

    Am J Hematol   Vol. 92   page: 1324-1332   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ajh.24905

  87. High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype.

    Koyama D, Murata M, Hanajiri R, Okuno S, Kamoshita S, Julamanee J, Takagi E, Hirano D, Miyao K, Sakemura R, Goto T, Hayakawa F, Seto A, Ozawa Y, Miyamura K, Terakura S, Nishida T, Kiyoi H.

    PLoS One12     page: e0185213   2017.9

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    DOI: 10.1371/journal.pone.0185213

  88. Deeper molecular response is a predictive factor for treatment-free remission after imatinib discontinuation in patients with chronic phase chronic myeloid leukemia: the JALSG-STIM213 study. Reviewed

    Takahashi N, Tauchi T, Kitamura K, Miyamura K, Saburi Y, Hatta Y, Miyata Y, Kobayashi S, Usuki K, Matsumura I, Minami Y, Usui N, Fukuda T, Takada S, Ishikawa M, Fujimaki K, Gomyo H, Sasaki O, Ohishi K, Miyake T, Imai K, Suzushima H, Mitsui H, Togitani K, Kiguchi T, Atsuta Y, Ohtake S, Ohnishi K, Kobayashi Y, Kiyoi H, Miyazaki Y, Naoe T; Japan Adult Leukemia Study Group.

    Int J Hematol     2017.9

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    DOI: 10.1007/s12185-017-2334-x

  89. High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG. Reviewed

    Sakura T, Hayakawa F, Sugiura I, Murayama T, Imai K, Usui N, Fujisawa S, Yamauchi T, Yujiri T, Kakihana K, Ito Y, Kanamori H, Ueda Y, Miyata Y, Kurokawa M, Asou N, Ohnishi K, Ohtake S, Kobayashi Y, Matsuo K, Kiyoi H, Miyazaki Y, Naoe T.

    Leukemia     2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/leu.2017.283

  90. Clinical effectiveness of geriatric assessment for predicting the tolerability of outpatient chemotherapy in older adults with cancer. Reviewed

    Hayashi N, Matsuoka A, Goto H, Gotoh M, Kiyoi H, Kodera Y, Nagino M, Nagashima F, Ando Y.

    J Geriatr Oncol     2017.8

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    DOI: 10.1016/j.jgo.2017.07.014

  91. Phase II study of intrabone single unit cord blood transplantation for hematological malignancies. Reviewed

    Murata M, Maeda Y, Masuko M, Onishi Y, Endo T, Terakura S, Ishikawa Y, Iriyama C, Ushijima Y, Goto T, Fujii N, Tanimoto M, Kobayashi H, Shibasaki Y, Fukuhara N, Inamoto Y, Suzuki R, Kodera Y, Matsushita T, Kiyoi H, Naoe T, Nishida T.

    Cancer Sci   Vol. 108   page: 1634-1639   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13291

  92. MOLECULAR MARKERS PREDICTING RESPONSE TO AZACITIDINE TREATMENT FOR MYELODYSPLASTIC SYNDROMES

    Nannya Y., Takeda J., Shiozawa Y., Shiraishi Y., Okuno Y., Kataoka K., Chiba K., Tanaka H., Sanada M., Chiba S., Asou N., Kiyoi H., Imai K., Hirase C., Dobashi N., Kiguchi T., Nakao S., Ohyashiki K., Miyazaki Y., Naoe T., Makishima H., Miyano S., Yoshida K., Ogawa S.

    HAEMATOLOGICA   Vol. 102   page: 98-99   2017.6

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  93. Management of infection during chemotherapy for acute leukemia in Japan: a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group. Reviewed

    Kimura SI, Fujita H, Kato H, Hiramoto N, Hosono N, Takahashi T, Shigeno K, Hatsumi N, Minamiguchi H, Miyatake J, Handa H, Akiyama N, Kanda Y, Yoshida M, Kiyoi H, Miyazaki Y, Naoe T; Japan Adult Leukemia Study Group (JALSG).

    Support Care Cancer   Vol. 25   page: 3515-3521   2017.6

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    DOI: 10.1007/s00520-017-3775-8

  94. [I.Genetic Abnormalities Associated with Acute Leukemia and a Development of Molecular Therapies].

    Adachi Y, Kiyoi H

    Gan to kagaku ryoho. Cancer & chemotherapy   Vol. 44 ( 5 ) page: 380-385   2017.5

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  95. Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia. Reviewed

    Togasaki E, Takeda J, Yoshida K, Shiozawa Y, Takeuchi M, Oshima M, Saraya A, Iwama A, Yokote K, Sakaida E, Hirase C, Takeshita A, Imai K, Okumura H, Morishita Y, Usui N, Takahashi N, Fujisawa S, Shiraishi Y, Chiba K, Tanaka H, Kiyoi H, Ohnishi K, Ohtake S, Asou N, Kobayashi Y, Miyazaki Y, Miyano S, Ogawa S, Matsumura I, Nakaseko C, Naoe T.

    Blood Cancer J   Vol. 7 ( 4 ) page: e559   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bcj.2017.36

  96. YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma. Reviewed

    Kojima Y, Hayakawa F, Morishita T, Sugimoto K, Minamikawa Y, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H.

    Pharmacol Res   Vol. 120   page: 242-251   2017.4

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    DOI: 10.1016/j.phrs.2017.04.006

  97. Retrospective analysis of in vivo recovery and clearance during continuous infusion of recombinant factor VIII products: a single-institution study

    Suzuki N., Hirakawa A., Kishimoto M., Kanematsu T., Ogawa M., Kiyoi H., Matsushita T.

    HAEMOPHILIA   Vol. 23 ( 2 ) page: 215-221   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/hae.13082

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  98. Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism.

    Aoki T, Shimada K, Sakamoto A, Sugimoto K, Morishita T, Kojima Y, Shimada S, Kato S, Iriyama C, Kuno S, Harada Y, Tomita A, Hayakawa F, Kiyoi H.

    Oncotarget   Vol. 8   page: 13085-13098   2017.2

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    DOI: 10.18632/oncotarget.14393

  99. Impact of T-cell chimerism on relapse after cord blood transplantation for hematological malignancies: Nagoya Blood and Marrow Transplantation Group study. Reviewed

    Yokohata E, Kuwatsuka Y, Ohashi H, Terakura S, Kawashima N, Seto A, Kurahashi S, Ozawa Y, Goto T, Imahashi N, Nishida T, Miyao K, Sakemura R, Kato T, Sawa M, Kohno A, Sao H, Iida H, Kiyoi H, Naoe T, Miyamura K, Murata M.

    Bone Marrow Transplant   Vol. 52   page: 612-614   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bmt.2016.323

  100. Malignant lymphoma with cardiac involvement.

    Terakura S, Onji M, Iriyama C, Goto T, Ushijima Y, Shimada K, Ishikawa Y, Nishida T, Hayakawa F, Murata M, Kiyoi H

    [Rinsho ketsueki] The Japanese journal of clinical hematology   Vol. 58 ( 3 ) page: 239-242   2017

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    DOI: 10.11406/rinketsu.58.239

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  101. A Tet-On Inducible System for Controlling CD19-Chimeric Antigen Receptor Expression upon Drug Administration. Reviewed

    Sakemura R, Terakura S, Watanabe K, Julamanee J, Takagi E, Miyao K, Koyama D, Goto T, Hanajiri R, Nishida T, Murata M, Kiyoi H.

    Cancer Immunol Res.   Vol. 4 ( 8 ) page: 658-68   2016.8

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    DOI: 10.1158/2326-6066.CIR-16-0043

  102. SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. Reviewed

    Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A, Kiyoi H.

    Cancer Sci.     page: [Epub ahead of print]   2016.6

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    DOI: doi: 10.1111/cas

  103. PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation. Reviewed

    Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, Naoe T, Kiyoi H.

    Biochem Biophys Res Commun.   Vol. 475 ( 2 ) page: 176-81   2016.6

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    DOI: 10.1016/j.bbrc.2016.05.067.

  104. Peripheral blood cell-free DNA is an alternative tumor DNA source reflecting disease status in myelodysplastic syndromes. Reviewed

    Suzuki Y, Tomita A, Nakamura F, Iriyama C, Shirahata-Adachi M, Shimada K, Akashi A, Ishikawa Y, Kaneda N, Kiyoi H.

    Cancer Sci.     page: [Epub ahead of print]   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.12994.

  105. Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells. Reviewed

    Chen F, Ishikawa Y, Akashi A, Naoe T, Kiyoi H.

    Oncotarget.     page: [Epub ahead of print]   2016.6

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    DOI: 10.18632/oncotarget.10147

  106. Live-cell single-molecule imaging of the cytokine receptor MPL for analysis of dynamic dimerization. Reviewed

    Sakamoto A, Tsukamoto T, Furutani Y, Sudo Y, Shimada K, Tomita A, Kiyoi H, Kato T, Funatsu T.

    J Mol Cell Biol.     page: [Epub ahead of print]   2016.6

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  107. BCR-ABL-specific CD4+ T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells. Reviewed

    Ueda N, Zhang R, Tatsumi M, Liu TY, Kitayama S, Yasui Y, Sugai S, Iwama T, Senju S, Okada S, Nakatsura T, Kuzushima K, Kiyoi H, Naoe T, Kaneko S, Uemura Y.

    Cell Mol Immunol     page: [Epub ahead of print]   2016.5

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    DOI: doi: 10.1038/cmi.2016.7

  108. Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells. Reviewed

    Maeda K, Enomoto A, Hara A, Asai N, Kobayashi T, Horinouchi A, Maruyama S, Ishikawa Y, Nishiyama T, Kiyoi H, Kato T, Ando K, Weng L, Mii S, Asai M, Mizutani Y, Watanabe O, Hirooka Y, Goto H, Takahashi M.

    Sci Rep.   Vol. 6   page: 22288   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep22288

  109. B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia. Reviewed

    Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.

    J Biol Chem.   Vol. 291 ( 9 ) page: 4723-31   2016.2

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    DOI: 10.1074/jbc.M115.637835.

  110. The first case of antithrombin-resistant prothrombin Belgrade mutation in Japanese. Reviewed

    Kishimoto M, Suzuki N, Murata M, Ogawa M, Kanematsu T, Takagi A, Kiyoi H, Kojima T, Matsushita T.

    Ann Hematol.   Vol. 95 ( 3 ) page: 541-2   2016.2

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  111. A case of MYH9 disorders caused by a novel mutation (p.K74E). Reviewed

    Kanematsu T, Suzuki N, Yoshida T, Kishimoto M, Aoki T, Ogawa M, Kagami Y, Kiyoi H, Matsushita T, Kunishima S.

    Ann Hematol   Vol. 95 ( 1 ) page: 161-3   2016.1

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    DOI: 10.1007/s00277-015-2506-9.

  112. Clinical usefulness of WT1 mRNA expression in bone marrow detected by a new WT1 mRNA assay kit for monitoring acute myeloid leukemia: a comparison with expression of WT1 mRNA in peripheral blood. Reviewed

    Kitamura K, Nishiyama T, Ishiyama K, Miyawaki S, Miyazaki K, Suzuki K, Masaie H, Okada M, Ogawa H, Imai K, Kiyoi H, Naoe T, Yokoyama Y, Chiba S, Hata T, Miyazaki Y, Hatta Y, Takeuchi J, Nannya Y, Kurokawa M, Ueda Y, Koga D, Sugiyama H, Takaku F.

    Int J Hematol.   Vol. 103 ( 1 ) page: 53-62   2016.1

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    DOI: 10.1007/s12185-015-1882-1.

  113. High-dose chemotherapy followed by autologous stem cell transplantation for relapsed/refractory primary mediastinal large B-cell lymphoma. Reviewed

    Aoki T, Shimada K, Suzuki R, Izutsu K, Tomita A, Maeda Y, Takizawa J, Mitani K, Igarashi T, Sakai K, Miyazaki K, Mihara K, Ohmachi K, Nakamura N, Takasaki H, Kiyoi H, Nakamura S, Kinoshita T, Ogura M.

    Blood Cancer J.   Vol. 5   page: e372   2015.12

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    DOI: 10.1038/bcj.2015.101

  114. Overview: A New Era of Cancer Genome in Myeloid Malignancies. Invited Reviewed

    Kiyoi H.

    Oncology.   Vol. 89 ( Suppl 1 ) page: 1-3   2015.11

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    Authorship:Lead author   Language:English  

    DOI: 10.1159/000431054

  115. Phase I trial of volasertib, a Polo-like kinase inhibitor, in Japanese patients with acute myeloid leukemia. Reviewed

    Kobayashi Y, Yamauchi T, Kiyoi H, Sakura T, Hata T, Ando K, Watabe A, Harada A, Taube T, Miyazaki Y, Naoe T.

    Cancer Sci.   Vol. 106 ( 11 ) page: 1590-5   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.12814.

  116. Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells. Reviewed

    Sugimoto K, Hayakawa F, Shimada S, Morishita T, Shimada K, Katakai T, Tomita A, Kiyoi H, Naoe T.

    Sci Rep.   Vol. 5   page: 13054   2015

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    DOI: 10.1038/srep13054

  117. Integration of humoral and cellular HLA-specific immune responses in cord blood allograft rejection. Reviewed

    Hanajiri R, Murata M, Sugimoto K, Murase M, Sakemura R, Goto T, Watanabe K, Imahashi N, Terakura S, Ohashi H, Akatsuka Y, Kurahashi S, Miyamura K, Kiyoi H, Nishida T, Naoe T.

    Bone Marrow Transplant   Vol. 50   page: 1187-94   2015

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    DOI: 10.1038/bmt.2015.119

  118. FLT3 Inhibitors: Recent Advances And Problems For Clinical Application. Invited Reviewed

    Kiyoi H

    Nagoya J Med Sci   Vol. 77   page: 7-17   2015

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  119. Chimerism status after unrelated donor bone marrow transplantation with fludarabine-melphalan conditioning is affected by the melphalan dose and is predictive of relapse. Reviewed

    Imahashi N, Ohashi H, Terakura S, Miyao K, Sakemura R, Kato T, Sawa M, Yokohata E, Kurahashi S, Ozawa Y, Nishida T, Kiyoi H, Watamoto K, Kohno A, Kasai M, Kato C, Iida H, Naoe T, Miyamura K, Murata M; for the Nagoya Blood and Marrow Transplantation Group.

    Ann Hematol   Vol. 94   page: 1139-48   2015

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    DOI: 10.1007/s00277-015-2312-4

  120. Simple and Efficient Generation of Virus-specific T Cells for Adoptive Therapy Using Anti-4-1BB Antibody. Reviewed

    Imahashi N, Nishida T, Goto T, Terakura S, Watanabe K, Hanajiri R, Sakemura R, Imai M, Kiyoi H, Naoe T, Murata M.

    J Immunother.   Vol. 38   page: 62-70   2015

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  121. Target Antigen Density Governs the Efficacy of Anti-CD20-CD28-CD3 ζ Chimeric Antigen Receptor-Modified Effector CD8+ T Cells. Reviewed

    Watanabe K, Terakura S, Martens AC, van Meerten T, Uchiyama S, Imai M, Sakemura R, Goto T, Hanajiri R, Imahashi N, Shimada K, Tomita A, Kiyoi H, Nishida T, Naoe T, Murata M.

    J Immunol.   Vol. 194   page: 911-20   2015

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  122. Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group. Reviewed

    Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T; Japan Adult Leukemia Study Group (JALSG).

    Blood Cancer J.   Vol. 4   page: e252   2014.10

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  123. De novo diffuse large B-cell lymphoma with a CD20 immunohistochemistry-positive and flow cytometry-negative phenotype: Molecular mechanisms and correlation with rituximab sensitivity. Reviewed

    Tokunaga T, Tomita A, Sugimoto K, Shimada K, Iriyama C, Hirose T, Shirahata-Adachi M, Suzuki Y, Mizuno H, Kiyoi H, Asano N, Nakamura S, Kinoshita T, Naoe T.

    Cancer Sci   Vol. 105   page: 35-43   2014

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  124. Efficacy of ofatumumab against rituximab-resistant B-CLL/SLL cells with low CD20 protein expression. Reviewed

    Shimada K, Tomita A, Saito S, Kiyoi H.

    Br J Haematol   Vol. 166   page: 455-457   2014

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  125. Expression of CD56 is an unfavorable prognostic factor for acute promyelocytic leukemia with higher initial white blood cell counts. Reviewed

    Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Emi N, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Kimura Y, Iwanaga M, Asou N, Naoe T; The Japan Adult Leukemia Study Group.

    Cancer Sci   Vol. 105   page: 97-104   2014

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  126. The demarcation between younger and older acute myeloid leukemia patients: a pooled analysis of 3 prospective studies. Reviewed

    Yanada M, Ohtake S, Miyawaki S, Sakamaki H, Sakura T, Maeda T, Miyamura K, Asou N, Oh I, Miyatake J, Kanbayashi H, Takeuchi J, Takahashi M, Dobashi D, Kiyoi H, Miyazaki Y, Emi N, Kobayashi Y, Ohno R, Naoe T.

    Cancer   ( 119 ) page: in press   2013

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  127. GATA2 zinc finger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation. Reviewed

    Niimi K, Kiyoi H, Ishikawa Y, Hayakawa F, Kurahashi S, Kihara R, Tomita A and Naoe T.

    Leukemia Research Reports   Vol. 2   page: 21-25   2013

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  128. Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation. Reviewed

    Ando K, Tsushima H, Matsuo E, Horio K, Tominaga-Sato S, Imanishi D, Imaizumi Y, Iwanaga M, Itonaga H, Yoshida S, Hata T, Moriuchi R, Kiyoi H, Nimer S, Mano H, Naoe T, Tomonaga M, Miyazaki Y.

    J Biol Chem   Vol. 288   page: 9457-9467   2013

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  129. Gene mutations of acute myeloid leukemia in the genome era. Invited Reviewed

    Naoe T, Kiyoi H

    Int J Hematol   Vol. 97   page: 165-174   2013

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  130. Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97. Reviewed

    Fujita H, Asou N, Iwanaga M, Hyo R, Nomura S, Kiyoi H, Okada M, Inaguma Y, Matsuda M, Yamauchi T, Ohtake S, Izumi T, Nakaseko C, Ishigatsubo Y, Shinagawa K, Takeshita A, Miyazaki Y, Ohnishi K, Miyawaki S, Naoe T; Japan Adult Leukemia Study Group.

    Cancer Sci   Vol. 104   page: 1339-45   2013

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  131. Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in acute promyelocytic leukemia. Invited Reviewed

    Tomita A, Kiyoi H, Naoe T.

    Int J Hematol   Vol. 97   page: 717-725   2013

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  132. Guest editorial: efficacy of and resistance to molecularly targeted therapy for myeloid malignancies. Invited Reviewed

    Kiyoi H.

    Int J Hematol   Vol. 97   page: 681-682   2013

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  133. Molecular lesions in childhood and adult acute megakaryoblastic leukaemia.

    Hama A, Muramatsu H, Makishima H, Sugimoto Y, Szpurka H, Jasek M, O'Keefe C, Takahashi Y, Sakaguchi H, Doisaki S, Shimada A, Watanabe N, Kato K, Kiyoi H, Naoe T, Kojima S, Maciejewski JP.

    Br J Haematol   Vol. 156   page: 316-325   2012

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  134. Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin. Reviewed

    Kajiguchi T, Katsumi A, Tanizaki R, Kiyoi H, Naoe T

    Eur J Haematol   Vol. 88   page: 314-20   2012

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  135. Long-term outcome of imatinib therapy, with assessment of its dosage and blood levels, for chronic myelogenous leukemia. Reviewed

    Ohnishi K, Nakaseko C, Takeuchi J, Fujisawa S, Nagai T, Yamazaki H, Tauchi T, Imai K, Mori N, Yagasaki F, Maeda Y, Usui N, Miyazaki Y, Miyamura K, Kiyoi H, Ohtake S, Naoe T.

    Cancer Sci   Vol. 103   page: 1071-1078   2012

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  136. Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome. Reviewed

    Iriyama C, Tomita A, Hoshino H, Shirahata M, Furukawa-Hibi Y, Yamada K, Kiyoi H, Naoe T.

    Biochem Biophys Res Commun   Vol. 419   page: 662-9   2012

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  137. CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737. Reviewed

    Shimada K, Tomita A, Minami Y, Abe A, Hind CK, Kiyoi H, Cragg MS, Naoe T.

    Exp Hematol   Vol. 40   page: 724-737   2012

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  138. Randomized comparison of fixed-schedule versus response-oriented individualized induction therapy and use of ubenimex during and after consolidation therapy for elderly patients with acute myeloid leukemia: the JALSG GML200 Study. Reviewed

    Wakita A, Ohtake S, Takada S, Yagasaki F, Komatsu H, Miyazaki Y, Kubo K, Kimura Y, Takeshita A, Adachi Y, Kiyoi H, Yamaguchi T, Yoshida M, Ohnishi K, Miyawaki S, Naoe T, Ueda R, Ohno R.

    Int J Hematol   Vol. 96   page: 84-93   2012

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  139. Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia. Reviewed

    Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S.

    Blood   Vol. 120   page: 1485-8   2012

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  140. Long-term outcome and prognostic factors of elderly patients with acute promyelocytic leukemia. Reviewed

    Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Kimura Y, Iwanaga M, Asou N, Naoe T.

    Cancer Sci   Vol. 103 ( 11 ) page: 1974-1978   2012

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  141. Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: JALSG AML201 Study. Reviewed

    Ohtake S, Miyawaki S, Fujita H, Kiyoi H, Shinagawa K, Usui N, Okumura H, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R.

    Blood   Vol. 117 ( 117 ) page: 2358-2365   2011

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  142. A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib-resistance: sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis. Reviewed

    Sakai K, Ishikawa Y, Mori Y, Kobayashi M, Iriyama C, Ozawa Y, Suzuki T, Minami Y, Ishikawa K, Kaneda N, Naoe T, Kiyoi H.

    Int J Hematol   Vol. 93   page: 237-242   2011

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  143. Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. Reviewed

    Katsumi A, Nishida T, Murata M, Terakura S, Shimada K, Saito S, Kobayashi M, Kodaira A, Shibata S, Oda I, Yagi T, Kiyoi H, Matsushita T, Kojima T, Naoe T.

    J Clin Exp Hematop   Vol. 51   page: 63-65   2011

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  144. Phase I trial of gemtuzumab ozogamicin in intensive combination chemotherapy for relapsed or refractory adult acute myeloid leukemia (AML): Japan Adult Leukemia Study Group (JALSG)-AML206 study. Reviewed

    Usui N, Takeshita A, Nakaseko C, Dobashi N, Fujita H, Kiyoi H, Kobayashi Y, Sakura T, Yahagi Y, Shigeno K, Ohwada C, Miyazaki Y, Ohtake S, Miyawaki S, Naoe T, Ohnishi K

    Cancer Sci   Vol. 102   page: 1358-1365   2011

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  145. Prevalence and clinical characteristics of N-terminally truncated WT1 expression in acute myeloid leukemia. Reviewed

    Ishikawa Y, Kiyoi H, Naoe T.

    Leuk Res   Vol. 35   page: 685-688   2011

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  146. A randomized comparison of four courses of standard-dose multiagent chemotherapy versus three courses of high-dose cytarabine alone in post-remission therapy for acute myeloid leukemia in adults: the JALSG AML201 study. Reviewed

    Miyawaki S, Ohtake S, Fujisawa S, Kiyoi H, Shinagawa K, Usui N, Sakura T, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R.

    Blood   Vol. 117   page: 2366-2372   2011

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  147. FLT3/ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signaling. Reviewed

    Katsumi A, Kiyoi H, Abe A, Tanizaki R, Iwasaki T, Kobayashi M, Matsushita T, Senga T, Kohno T, Kojima T, Kaibuchi K, Hamaguchi M, Naoe T.

    Eur J Haematol   Vol. 86   page: 191-198   2011

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  148. Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study. Reviewed

    Ishikawa Y, Kiyoi H, Watanabe K, Miyamura K, Nakano Y, Kitamura K, Kohno A, Sugiura I, Yokozawa T, Hanamura A, Yamamoto K, Iida H, Emi N, Suzuki R, Ohnishi K, Naoe T.

    Cancer Sci   Vol. 101   page: 2186-2192   2010.10

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  149. Imatinib for newly diagnosed chronic-phase chronic myeloid leukemia: results of a prospective study in Japan. Reviewed

    Nagai T, Takeuchi J, Dobashi N, Kanakura Y, Taniguchi S, Ezaki K, Nakaseko C, Hiraoka A, Okada M, Miyazaki Y, Motoji T, Higashihara M, Tsukamoto N, Kiyoi H, Nakao S, Shinagawa K, Ohno R, Naoe T, Ohnishi K, Usui N.

    Int J Hematol   Vol. 92   page: 111-117   2010.7

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  150. Array-based genomic resequencing of human leukemia. Reviewed

    Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, Mano H.

    Oncogene   Vol. 29   page: 3723-3731   2010.6

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  151. BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4. Reviewed

    Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T.

    Eur J Haematol   Vol. 84   page: 229-238   2010

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  152. Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia. Reviewed

    Tsujimura A, Kiyoi H, Shiotsu Y, Ishikawa Y, Mori Y, Ishida H, Toki T, Ito E, Naoe T.

    Int J Hematol   Vol. 92   2010

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  153. Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. Reviewed

    Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R.

    J Clin Oncol   Vol. 28   page: 1591-1598   2010

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  154. Randomized trial of response-oriented individualized versus fixed-schedule induction chemotherapy with idarubicin and cytarabine in adult acute myeloid leukemia: the JALSG AML95 study. Reviewed

    Ohtake S, Miyawaki S, Kiyoi H, Miyazaki Y, Okumura H, Matsuda S, Nagai T, Kishimoto Y, Okada M, Takahashi M, Handa H, Takeuchi J, Kageyama S, Asou N, Yagasaki F, Maeda Y, Ohnishi K, Naoe T, Ohno R.

    Int J Hematol   Vol. 91   page: 276-283   2010

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  155. Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD / SCID / IL-2Rgammac mice. Reviewed

    Tanizaki R, Nomura Y, Miyata Y, Minami Y, Abe A, Hanamura A, Sawa M, Murata M, Kiyoi H, Matsushita T, Naoe T.

    Cancer Sci   Vol. 101   page: 631-638   2010

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  156. Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment. Reviewed

    Minami Y, Kajiguchi T, Abe A, Ohno T, Kiyoi H, Naoe T.

    Int J Hematol   Vol. 92   page: 664-666   2010

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  157. Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance. Reviewed

    Hiraga J, Tomita A, Sugimoto T, Shimada K, Ito M, Nakamura S, Kiyoi H, Kinoshita T, Naoe T.

    Blood   Vol. 113   page: 4885-4893   2009

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  158. Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. Reviewed

    Inamoto Y, Murata M, Katsumi A, Kuwatsuka Y, Tsujimura A, Ishikawa Y, Sugimoto K, Onizuka M, Terakura S, Nishida T, Kanie T, Taji H, Iida H, Suzuki R, Abe A, Kiyoi H, Matsushita T, Miyamura K, Kodera Y, Naoe T.

    Bone Marrow Transplant   Vol. 45   page: 363-369   2009

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  159. Escape mechanisms from antibody therapy to lymphoma cells: downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation. Reviewed

    Sugimoto T, Tomita A, Hiraga J, Shimada K, Kiyoi H, Kinoshita T, Naoe T.

    Biochem Biophys Res Commun   Vol. 390   page: 48-53   2009

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  160. CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma. Reviewed

    Takeshita A, Shinjo K, Yamakage N, Ono T, Hirano I, Matsui H, Shigeno K, Nakamura S, Tobita T, Maekawa M, Ohnishi K, Sugimoto Y, Kiyoi H, Naoe T, Ohno R.

    Br J Haematol   Vol. 146   page: 34-43   2009

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  161. CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells. Reviewed

    Takeshita A, Yamakage N, Shinjo K, Ono T, Hirano I, Nakamura S, Shigeno K, Tobita T, Maekawa M, Kiyoi H, Naoe T, Ohnishi K, Sugimoto Y, Ohno R.

    Leukemia   Vol. 23   page: 1329-1336   2009

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  162. Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia. Reviewed

    Ishikawa Y, Kiyoi H, Tsujimura A, Miyawaki S, Miyazaki Y, Kuriyama K, Tomonaga M, Naoe T.

    Eur J Haematol   Vol. 83   page: 90-98   2009

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  163. Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome. Reviewed

    10. Xu J, Suzuki M, Niwa Y, Hiraga J, Nagasaka T, Ito M, Nakamura S, Tomita A, Abe A, Kiyoi H, Kinoshita T, Naoe T.

    Br J Haematol.   Vol. 140   page: 394-401   2008

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  164. Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. Reviewed

    Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang JY, Naoe T.

    Int J Hematol   Vol. 88   page: 471-475   2008

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  165. Prognostic implication and biological roles of RhoH in acute myeloid leukaemia. Reviewed

    Iwasaki T, Katsumi A, Kiyoi H, Tanizaki R, Ishikawa Y, Ozeki K, Kobayashi M, Abe A, Matsushita T, Watanabe T, Amano M, Kojima T, Kaibuchi K, Naoe T.

    Eur J Haematol   Vol. 81   page: 454-460   2008

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  166. Mutational analysis of SOS1 gene in acute myeloid leukemia. Reviewed

    Tanizaki R, Katsumi A, Kiyoi H, Kunishima S, Iwasaki T, Ishikawa Y, Kobayashi M, Abe A, Matsushita T, Watanabe T, Kojima T, Kaibuchi K, Kojima S, Naoe T.

    Int J Hematol   Vol. 88   2008

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  167. Novel and orally active 5-(1,3,4-oxadiazol-2-yl)pyrimidine derivatives as selective FLT3 inhibitors. Reviewed

    Ishida H, Isami S, Matsumura T, Umehara H, Yamashita Y, Kajita J, Fuse E, Kiyoi H, Naoe T, Akinaga S, Shiotsu Y, Arai H.

    Bioorg Med Chem Lett.   Vol. 18   page: 5472-5477   2008

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  168. Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan. Reviewed

    Narimatsu H, Iino M, Ichihashi T, Yokozawa T, Hayakawa M, Kiyoi H, Takeo T, Sawamoto A, Iida H, Tsuzuki M, Yanada M, Naoe T, Suzuki R, Sugiura I.

    Int J Hematol   Vol. 88   2008

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  169. Karyotypically independent clones with del(11q) and trisomy 10 in acute myeloid leukemia: trisomy 10 may appear as an additional change. Reviewed

    Gotoh M, Sasaki Y, Iguchi T, Fujimoto H, Kodama A, Kiyoi H, Naoe T, Ohyashiki K.

    Int J Hematol   Vol. 88   page: 123-124   2008

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  170. Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review. Reviewed

    Murata M, Ishikawa Y, Ohashi H, Terakura S, Ozeki K, Kiyoi H, Naoe T.

    Int J Hematol   Vol. 88   page: 111-115   2008

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  171. Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome. Reviewed

    Sato T, Toki T, Kanezaki R, Xu G, Terui K, Kanegane H, Miura M, Adachi S, Migita M, Morinaga S, Nakano T, Endo M, Kojima S, Kiyoi H, Mano H, Ito E.

    Br J Haematol.   Vol. 141   page: 681-688   2008

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  172. Mutations of JAK2, JAK3 and GATA1 in acute megakaryoblastic leukemia of Down syndrome. Reviewed

    8. Hama A, Yagasaki H, Takahashi Y, Matsumoto K, Kiyoi H, Kojima S.

    Blood   Vol. 111   page: 2493-2494   2008

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  173. Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan. Reviewed

    9. Narimatsu H, Yokozawa T, Iida H, Tsuzuki M, Hayakawa M, Takeo T, Iino M, Ichihashi T, Kato C, Sawamoto A, Sao H, Yanada M, Emi N, Kiyoi H, Yamaguchi T, Naoe T, Suzuki R, Sugiura I.

    Leukemia   Vol. 22   page: 432-434   2008

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  174. Clinical features and outcome of T-lineage acute lymphoblastic leukemia in adults: A low initial white blood cell count, as well as a high count predict decreased survival rates. Reviewed

    Yanada M, Jinnai I, Takeuchi J, Ueda T, Miyawaki S, Tsuzuki M, Hatta Y, Usui N, Wada H, Morii T, Matsuda M, Kiyoi H, Okada M, Honda S, Miyazaki Y, Ohno R, Naoe T.

    Leukemia Res   Vol. 31   2007

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  175. LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). Reviewed

    Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T.

    Eur J Haematol.   Vol. 78   2007

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  176. FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells. Reviewed

    Kajiguchi T, Chung EJ, Lee S, Stine A, Kiyoi H, Naoe T, Levis MJ, Neckers L, Trepel JB.

    Leukemia   Vol. 21   2007

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  177. Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan. Reviewed

    Narimatsu H, Yokozawa T, Iida H, Tsuzuki M, Hayakawa M, Takeo T, Iino M, Ichihashi T, Kato C, Sawamoto A, Sao H, Yanada M, Emi N, Kiyoi H, Yamaguchi T, Naoe T, Suzuki R, Sugiura I.

    Leukemia   Vol. 21   2007

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  178. High incidence of secondary failure of platelet recovery after autologous and syngeneic peripheral blood stem cell transplantation in acute promyelocytic leukemia. Reviewed

    Narimatsu H, Emi N, Kohno A, Iwai M, Yanada M, Yokozawa T, Saito S, Shimada K, Kiyoi H, Naoe T, Yamamoto K, Morishita Y.

    Bone Marrow Transplant   Vol. 40   2007

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  179. Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma. Reviewed

    Hiraga J, Katsumi A, Iwasaki T, Abe A, Kiyoi H, Matsushita T, Kinoshita T, Naoe T.

    Leukemia   Vol. 21   2007

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  180. Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. Reviewed

    Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T.

    Leukemia   Vol. 21   page: 136   2007

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  181. Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD. Reviewed

    Okamoto M, Hayakawa F, Miyata Y, Watamoto K, Emi N, Abe A, Kiyoi H, Towatari M, Naoe T.

    Leukemia   Vol. 21   page: 403   2007

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  182. JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. Reviewed

    Kiyoi H, Yamaji S, Kojima, Naoe T.

    Leukemia   Vol. 21   page: 574   2007

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  183. Epegenetic regulation of CD20 protein expression in a novel B-cell lymphoma cell line, RRBL1, established from a patient treated repeatedly with Rituximab-containing chemotherapy. Reviewed

    Tomita A, Hiraga J, Kiyoi H, Ninomiya M, Sugimoto T, Ito M, Kinoshita T, Naoe T.

    Int J Hematol   Vol. 84   2007

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  184. A novel FLT3 inhibitor FI-700 selectively suppress the growth of leukemia cells with FLT3 mutations. Reviewed

    Kiyoi H, Shiotsu Y, Ozeki K, Yamaji S, Kosugi H, Umehara H, Arai H, Ishii K, Akinaga S, Naoe T.

    Clin Cancer Res   Vol. 13   page: 4575-4582   2007

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  185. Successful second cord blood transplantation using fludarabine and cyclophosphamide as a preparative regimen for graft rejection following reduced-intensity cord blood transplantation. Reviewed

    Mizutani E, Narimatsu H, Murata M, Tomita A, Kiyoi H, Naoe T.

    Bone Marrow Tranaplant   Vol. 32   2007

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  186. A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RAR{alpha} transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study. Reviewed

    Asou N, Kishimoto Y, Kiyoi H, Okada M, Kawai Y, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Kobayashi T, Ohtake S, Nishimura M, Takahashi M, Yagasaki F, Takeshita A, Kimura Y, Iwanaga M, Naoe T, Ohno R.

    Blood   Vol. 107   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

  187. Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo. Reviewed

    Atsumi A, Tomita A, Kiyoi H, Naoe T.

    BBRC   Vol. 345   page: 1471   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  188. FLT3 mutations in acute myeloid leukemia. Invited Reviewed

    Kiyoi H, Naoe T.

    Meth Molec Med   Vol. 125   page: 189   2006

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  189. PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. Reviewed

    Yamamoto T, Isomura M, Xu Y, Liang J, Yagasaki H, Kamachi Y, Kudo K, Kiyoi H, Naoe T, Kojma S.

    Leukemia Res   Vol. 30   page: 1085   2006

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  190. Mutations of N-RAS, FLT3 and p53 genes are not involved in the development of acute leukemia transformed from myeloproliferative diseases with JAK2 mutation. Reviewed

    Suzuki M, Abe A, Kiyoi H, Murata M, Ito Y, Shimada K, Morishita Y, Kinoshita T, Naoe T.

    Leukemia   Vol. 20   page: 1168   2006

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  191. Micafungin, a novel antifungal agent, as empirical therapy in acute leukemia patients with febrile neutropenia. Reviewed

    Yanada M, Kiyoi H, Murata M, Suzuki M, Iwai M, Yokozawa T, Baba H, Emi N, Naoe T.

    Intern Med   Vol. 45   page: 259   2006

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  192. Biology, clinical relevance, and moleculary targeted therapy in acute leukemia with FLT3 mutations. Invited Reviewed

    Kiyoi H, Naoe T.

    Int J Hematol   Vol. 83   page: 301   2006

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  193. Establishment of a Stroma-Dependent Human Acute Myelomonocytic Leukemia Cell Line, NAMO-2, with FLT3 Tandem Duplication. Reviewed

    Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A, Emi N, Naoe T.

    Int J Hematol   Vol. 84   page: 328   2006

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  194. Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. Reviewed

    Karnan S, Tsuzuki S, Kiyoi H, Tagawa H, Ueda R, Seto M, Naoe T.

    Gene Chromosome Canc   Vol. 45   page: 420   2006

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  195. Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation. Reviewed

    Yanada M, Matsushita T, Suzuki M, Kiyoi H, Yamamoto K, Kinoshita T, Kojima T, Saito H, Naoe T.

    Eur J Haematol   Vol. 77   page: 282   2006

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  196. Nucleophosmin: a versatile molecule associated with hematological malignancies. Reviewed

    Naoe T, Suzuki T, Kiyoi H, Urano T.

    Cancer Sci   Vol. 97   page: 963   2006

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  197. Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene. Reviewed

    Ninomiya M, Abe A, Yokozawa T, Ozeki K, Yamamoto K, Ito M, Ito M, Kiyoi H, Emi N, Naoe T.

    Cancer Genet Cytogen   Vol. 169   page: 1   2006

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  198. *Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia. Reviewed

    Suzuki T, Kiyoi H, Ozeki K, Tomita A, Yamaji S, Suzuki R, Kodera Y, Miyawaki S, Asou N, Kuriyama K, Yagasaki F, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Kinoshita T, Emi N, Naoe T.

    Blood   Vol. 106   page: 2854   2005

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  199. BMI-1 Is Highly Expressed in M0-Subtype Acute Myeloid Leukemia. Reviewed

    Sawa M, Yamamoto K, Yokozawa T, Kiyoi H, Hishida A, Kajiguchi T, Seto M, Kohno A, Kitamura K, Itoh Y, Asou N, Hamajima N, Emi N, Naoe T.

    Int J Hematol   Vol. 82   page: 42   2005

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  200. Long-term outcomes for unselected patients with acute myeloid leukemia categorized according to the World Health Organization classification: a single-center experience. Reviewed

    Yanada M, Suzuki M, Kawashima K, Kiyoi H, Kinoshita T, Emi N, Saito H, Naoe T.

    Eur J Haematol   Vol. 74   page: 418   2005

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  201. Clinical significance of FLT3 in leukemia. Invited Reviewed

    Kiyoi H, Yanada M, Ozeki K.

    Int J Hematol   Vol. 82   page: 85   2005

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    Language:English   Publishing type:Research paper (scientific journal)  

  202. Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome. Reviewed

    Iwai M, Kiyoi H, Ozeki K, Kinoshita T, Emi N, Ohno R, Naoe T.

    Leukemia   Vol. 19   page: 1367   2005

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  203. Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis. Reviewed

    Yanada M, Matsuo K, Suzuki T, Kiyoi H, Naoe T.

    Leukemia   Vol. 19   page: 1345   2005

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  204. *Biological and clinical significance of the FLT3 transcript level in acute myeloid leukemia. Reviewed

    Ozeki K, Kiyoi H, Hirose Y, Iwai M, Ninomiya M, Kodera Y, Miyawaki S, Kuriyama K, Shimazaki C, Akiyama H, Nishimura M, Motoji T, Shinagawa K, Takeshita A, Ueda R, Ohno R, Emi N, Naoe T.

    Blood   Vol. 103   page: 1901   2004

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  205. Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia. Reviewed

    Yanada M, Terakura S, Yokozawa T, Yamamoto K, Kiyoi H, Emi N, Kitamura K, Kohno A, Tanaka M, Tobita T, Takeo T, Sao H, Kataoka T, Kobayashi M, Takeshita A, Morishita Y, Sugiura I, Naoe T.

    Leukemia Lymphoma   Vol. 45   page: 1803   2004

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  206. Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line. Reviewed

    Ninomiya M, Kiyoi H, Ito M, Hirose Y, Ito M, Naoe T.

    Leukemia   Vol. 18   page: 442   2004

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  207. Normal and oncogenic FLT3. Invited Reviewed

    Naoe T, Kiyoi H.

    Cell Mol Life Sci   Vol. 61   page: 2932   2004

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  208. Different anti-apoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia. Reviewed

    Minami Y, Yamamoto K, Kiyoi H, Ueda R, Saito H, Naoe T.

    Blood   Vol. 102   page: 2969   2003

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  209. Comprehensive analysis of gene alterations in acute megakaryoblastic leukemia of Down syndrome. Reviewed

    Hirose Y, Kudo K, Kiyoi H, Hayashi Y, Naoe T, Kojima S.

    Leukemia   Vol. 17   page: 2250   2003

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  210. A xeno-transplantable plasma cell leukemia line with a split translocation of the IgH gene. Reviewed

    Ohbayashi K, Taniwaki M, Ninomiya M, Kiyoi H, Iida S, Ueda R, Naoe T.

    Cancer Genet Cytogen   Vol. 144   page: 31   2003

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  211. Prognostic significance of the null genotype of glutathione S-transferase-T1 in patients with acute myeloid leukemia: increased early death after chemotherapy Reviewed

    Leukemia   Vol. 16   page: 203-208   2002

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  212. FLT3 in human hematologic malignancies. Invited Reviewed

    Kiyoi H, Naoe T.

    Leukemia Lymphoma   Vol. 43   page: 1541   2002

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  213. Rapid screening of leukemia fusion transcripts in acute leukemia by Real-time PCR. Reviewed

    Osumi K, Fukui T, Kiyoi H, Kasai M, Kodera Y, Kudo K, Kato K, Matsuyama M, Naito K, Tamimoto M, Hirai H, Saito H, Ohno R, Naoe T.

    Leukemia Lymphoma   Vol. 43   page: 2291   2002

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  214. Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11 Reviewed

    Leukemia   Vol. 16   page: 2205-2212   2002

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  215. Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors Reviewed

    Leukemia   Vol. 16   page: 1535-1540   2002

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  216. Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain Reviewed

    Kiyoi H, Ohno R, Ueda R, Saito H, Naoe T.

    Oncogene   Vol. 21   page: 2555-2563   2002

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  217. Successful treatment with imatinib mesylate of a CML patient in megakaryoblastic crisis with severe fibrosis. Reviewed

    Hirose Y, Kiyoi H, Iwai M, Yokozawa T, Ito M, Naoe T.

    Int J Hematol   Vol. 76   page: 349   2002

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  218. Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations Reviewed

    Jpn J Cancer Res   Vol. 92   page: 638-644   2001

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  219. B-cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony-stimulating factor-mobilized peripheral blood CD34+ cells Reviewed

    Immunology   Vol. 104   page: 410-417   2001

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  220. FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy Reviewed

    Cancer Chemother Pharmacol   Vol. 48   page: 27-30   2001

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  221. Immunoglobulin variable region structure and B cell malignancies. Reviewed

    Kiyoi H, Naoe T.

    Int J Hematol   Vol. 73   page: 47   2001

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  222. Prognostic significance of the cell cycle inhibitor p27Kip1 in acute myeloid leukemia.

    Leukemia   Vol. 14   page: 28-33   2000

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  223. Leukemia relapse reconsidered from the molecular aspect.

    Leukemia and Lymphoma   Vol. 37   page: 527-534   2000

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  224. Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid.

    Br J Haematol   Vol. 108   page: 696-702   2000

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  225. Identification of a novel putative Ran-binding protein and its close homologue

    Biochem Biophys Res Commun   Vol. 278   page: 241-249   2000

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  226. Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia. Reviewed

    Clin Cancer Res   Vol. 6   page: 4091-4095   2000

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  227. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Reviewed

    Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T.

    Oncogene   Vol. 19   page: 624-631   2000

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  228. Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia.

    Eur J Haematol   Vol. 65   page: 23-31   2000

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  229. In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor.

    Leukemia   Vol. 14   page: 374-378   2000

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  230. Poor clinical significance of p53 gene polymorphism in acute myeloid leukemia.

    Leuk Res   Vol. 24   page: 349-352   2000

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  231. Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis. Reviewed

    Kitamura K, Minami Y, Yamamoto K, Akao Y, Kiyoi H, Saito H, Naoe T.

    Leukemia   Vol. 14   page: 1743   2000

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  232. Review of the immunoglobulin light chain variable region sequences from multiple myeloma cells.

    Leukemia   Vol. 13   page: 829-830   1999

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  233. Accurate quantitation of residual tumor burden at bone marrow harvest predicts timing of subsequent relapse in patients with common ALL treated by autologous bone marrow transplantation. Nagoya BMT Group.

    Bone Marrow Transplant   Vol. 24   page: 777-784   1999

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  234. Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy.

    Leukemia   Vol. 13   page: 1316-1324   1999

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  235. Molecular evolution of acute myeloid leukaemia in relapse : unstable N-ras and FLT3 genes compared with p53 gene.

    Br J Haematol   Vol. 104   page: 659-664   1999

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  236. Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation.

    Leukemia   Vol. 13   page: 585-589   1999

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  237. Etoposide-realted acute promyelocytic leukemia.

    Leukemia   Vol. 12   page: 1171-1175   1998

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  238. Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia.

    Br J Haematol   Vol. 101   page: 521-528   1998

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  239. Characterization of the immunoglobulin light chain variable region gene expressed in multiple myeloma.

    Leukemia   Vol. 12   page: 601-609   1998

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  240. Prognostic significance of TEL/AML1 fusion transcript in childhood B-precursor acute lymphoblastic leukemia.

    J Pediatr Hematolo/oncolo   Vol. 20   page: 190-195   1998

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  241. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines.

    Leukemia   Vol. 11   page: 1605-1609   1997

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    Language:English  

  242. Comparison of the immunoglobulin gene transcripts between immature B lineage acute lymphoblastic leukemia and the normal phenotypic counterparts in the bone marrow.

    Leukemia   Vol. 11   page: 1274-1280   1997

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  243. Mutant AF-2 domain of PML-RARα in retinoic acid-resistant NB4 cells : differentiation induced by RA is triggered directly through PML-RARα and its down-regulation in acute promyelocytic leukemia.

    Leukemia   Vol. 11   page: 1950-1956   1997

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    Language:English  

  244. Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia.

    Leukemia   Vol. 11   page: 1447-1452   1997

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  245. Unusual feature of the T-cell receptor genes in T-lineage acute lymphoblastic leukemia.

    Leuk Res   Vol. 21   page: 667-674   1997

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  246. New retinoids and arsenic compounds for the treatment of refractory acute promyelocytic leukemia : clinical and basic studies for the next generation.

    Cancer Chemotherapy & Pharmacology   Vol. 40   page: S36-S41   1997

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  247. Comparable gene structure of the immunoglobulin heavy chain variable region between multiple myeloma and normal bone marrow lymphocytes.

    Leukemia   Vol. 10   page: 1804-1812   1996

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    Language:English  

  248. Different T-cell receptor repertoires between lesions and peripheral blood in acute graft-versus-host disease after allogeneic bone marrow transplantation.

    Blood   Vol. 87   page: 3019-3026   1996

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    Language:English  

  249. Comparison of the immunoglobulin heavy-chain complementarity determining region-3 structure among the DNA sequences and the μ-and γ-transcripts in human B-lineage cells.

    Immunology   Vol. 89   page: 324-330   1996

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    Language:English  

  250. Comparable profiles of the immunoglobulin heavy chain complementarity determining region(CDR)-3 in CD5+ and CD5- human cord blood B lymphocytes.

    Immunology   Vol. 85   page: 236-240   1995

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    Language:English  

  251. Detection of minimal residual disease in patients with childhood common acute lymphoblastic leukemia after autologous bone marrow trasplantation with ex vivo purging and systemic IL-2 infusion : unsuccessful prediction of subsequent relapse.

    Bone Marrow Transplant   Vol. 16   page: 437-442   1995

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    Language:English  

  252. Continuing immunoglobulin heavy chain gene rearrangements in chronic myeloid leikemia with recurrent B-lymphoid blast crises after bone marrow transplantation.

    Leukemia   Vol. 9   page: 265-270   1995

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    Language:English  

  253. Analysis of the joining sequences of the t(15 ; 17)translocation in human acute pronyelocytic leukemia : sequence non-specific recombination between the PML and RARA genes within identical short stretches.

    Genes, Chromosomes & Cancer   Vol. 12   page: 37-44   1995

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    Language:English  

  254. Prognostic significance of the RT-PCR assay of PML-RARA trascripts in acute promyelocytic leukemia.

    Leukemia   Vol. 9   page: 588-593   1995

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    Language:English  

  255. Characterization of immunoglobulin heavy chain gene rearrangements in chronic myeloid leikemia with recurrent B-lymphoid blast crisis following bone marrow transplantation.

    Int Med   Vol. 33   page: 786-789   1994

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    Language:English  

  256. Minimal residual disease status in pre-B acute lymphoblastic leukemia patients after chemotherapy and bone marrow trasplantation : assessment of the antileukemic effects of chemotherapy and BMT.

    Leuk Res   Vol. 17   page: 674-684   1993

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    Language:English  

  257. Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia.

    Jap J Cancer Res   Vol. 84   page: 379-387   1993

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    Language:English  

  258. Involvement of the MLL/ALL-1 gene associated with multiple point mutations of the N-ras gene in acute myeloid leukemia with t(11 : 17)(q23 ; q25).

    Blood   Vol. 82   page: 2260-2261   1993

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    Language:English  

  259. Effective treatment of adult T cell leukemia/lymphoma with a novel oral antitumor agent, MST-16.

    Oncology   Vol. 49   page: 333-335   1992

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  260. Characterization of the immunoglobulin heavy chain complementarity determining region(CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells. Reviewed

    J Clin Invest   Vol. 89   page: 739-746   1992

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  261. Hermolytic uraemic syndrome during FK506 therapy.

    Lancet   Vol. 340   page: 60-61   1992

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    Language:English  

  262. Development of hyperthyroidism in donor and recipient after allogeneic bone marrow transplantation.

    Bone Marrow Transplant   Vol. 10   page: 397-398   1992

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    Language:English  

  263. Disappearance of minimal residual lymphoblastic leukemia cells 6 months after allogeneic bone marrow transplantation without GVHD. Reviewed

    Bone Marrow Transplant   Vol. 8   page: 59-62   1991

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  264. A case of cALL relapse after allogeneic BMT : recurrence of recipient cell origin, initially determined as being that of donor cell origin by sex chromosome analysis. Reviewed

    Br J Haematolo   Vol. 73   page: 420-422   1989

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▼display all

Books 22

  1. 白血病治療マニュアル

    清井仁( Role: Joint editor)

    南江堂  2020.11  ( ISBN:978-4-524-22664-1

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    Total pages:348   Language:Japanese Book type:Scholarly book

  2. Annual Review血液2011・急性白血病に対するFLT3阻害薬とファルネシル転移酵素阻害薬

    清井 仁( Role: Joint author)

    中外医学社  2011 

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    Language:Japanese

  3. WHO血液腫瘍分類〜WHO分類2008をうまく活用するために〜・NPM1遺伝子変異を伴う急性骨髄性白血病、CEBPA遺伝子変異を伴う急性骨髄性白血病

    清井 仁( Role: Joint author)

    医薬ジャーナル社  2010 

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    Language:Japanese

  4. EBMがん化学療法・分子標的治療法2011-2012・急性前骨髄球性白血病再発例における亜ヒ酸のエビデンスとその位置づけ

    清井 仁( Role: Joint author)

    中外医学社  2010 

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    Language:Japanese

  5. 血液疾患最新の治療2011-2013・正常核型急性骨髄性白血病におけるゲノム・分子異常

    清井 仁( Role: Joint author)

    南江堂  2010 

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    Language:Japanese

  6. 造血器腫瘍治療第2版 これは困ったぞ, どうしよう!・AMLのリスク分類とそれに基づく治療選択の現状は?

    清井 仁( Role: Joint author)

    中外医学社  2010 

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    Language:Japanese

  7. がんの分子標的と治療薬事典・FLT3

    清井 仁( Role: Joint author)

    羊土社  2010 

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    Language:Japanese

  8. 造血器腫瘍アトラス 形態、免疫、染色体と遺伝子 第4版・急性骨髄性白血病におけるNPM1遺伝子突然変異

    清井 仁( Role: Joint author)

    日本医事新報社  2009 

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    Language:Japanese

  9. 臨床に直結する血液疾患診療のエビデンス・急性骨髄性白血病の予後因子

    清井 仁( Role: Joint author)

    文光堂  2009 

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    Language:Japanese

  10. WHO分類第4版による白血病・リンパ系腫瘍の病態学・急性骨髄性白血病および関連前駆細胞性腫瘍

    清井 仁、直江知樹( Role: Joint author)

    中外医学社  2009 

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    Language:Japanese

  11. 講義録 血液・造血器疾患学 フローサイトメトリ

    清井 仁( Role: Joint author)

    メジカルビュー社  2008 

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    Language:Japanese

  12. 新しい診断と治療のABC・急性白血病・病因

    清井 仁( Role: Joint author)

    最新医学社  2006 

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    Language:Japanese

  13. 分子標的療法の基礎と臨床・FLT3を標的にした白血病の治療

    清井 仁、直江知樹( Role: Joint author)

    篠原出版新社  2005 

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    Language:Japanese

  14. 分子標的治療薬「作用機序と臨床」・細胞内シグナル伝達系を阻害する薬剤、チロシンキナーゼ阻害剤/FLT3阻害剤(MLN518, PKC412, CEP-701)

    清井 仁( Role: Joint author)

    メディカルレビュー社  2005 

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    Language:Japanese

  15. 血液・固形腫瘍診断マニュアル改定版・タンパク分析法

    清井 仁( Role: Joint author)

    フジメディカル出版  2002 

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    Language:Japanese

  16. 臨床血液実験操作法・免疫グロブリン遺伝子を用いたクローナリティーの解析

    清井 仁( Role: Joint author)

    科学評論社  2000 

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    Language:Japanese

  17. 血液・固形腫瘍診断マニュアル・タンパク分析法

    清井 仁( Role: Joint author)

    フジメディカル出版  2000 

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    Language:Japanese

  18. 別冊・医学のあゆみ:血液疾患-state of arts Ver. 2免疫グロブリン遺伝子による微量残存白血病の診断

    清井 仁( Role: Joint author)

    医歯薬出版  1998 

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    Language:Japanese

  19. 図説臨床癌シリーズno. 17 白血病・リンパ腫 新版minimal residual disease (MRD)の検出とその意義

    清井 仁、大野竜三( Role: Joint author)

    メジカルビュー社  1994 

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    Language:Japanese

  20. 免疫グロブリン遺伝子による微量残存白血病の診断、溝口秀昭、平井久丸、坂田洋一編集、別冊・医学のあゆみ:血液疾患-state of arts

    清井 仁( Role: Joint author)

    医歯薬出版  1993 

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    Language:Japanese

  21. Polymerase chain reaction for the detection of minimal residual B-cell clones using diversity of complementarity determining region (CDR) III. In “Cancer Chemotherapy: Challenges for the Future Volume 6” (Ed.)

    Naoe T. Kiyoi H. Ohno R( Role: Joint author)

    Excerpta Medica  1991 

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    Language:English

  22. Current review 癌化学療法1990~91各臓器癌の化学療法:白血病・骨髄腫

    清井 仁、山田一正( Role: Joint author)

    中外医学社  1990 

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    Language:Japanese

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MISC 11

  1. 【令和時代の洗練された造血器腫瘍治療】急性骨髄性白血病の個別化医療 Invited

    石川裕一、清井仁

    Precision Medicine   Vol. 4 ( 1 ) page: 14 - 17   2021.1

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    Authorship:Last author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  2. 【いま知っておきたい! 内科最新トピックス】(第3章)血液・造血器 急性骨髄性白血病に対する新規小分子治療薬 Invited

    中島 麻梨絵, 清井 仁

    内科   Vol. 26 ( 3 ) page: 449 - 451   2020.9

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    Authorship:Last author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  3. 治療法の再整理とアップデートのために 専門家による私の治療 急性骨髄性白血病(AML) Invited

    清井仁

    日本医事新報   ( 5029 ) page: 39 - 40   2020.9

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  4. 【造血器腫瘍の分子標的治療の最前線】急性骨髄性白血病 Invited

    川島直実、清井仁

    がん分子標的治療   Vol. 18 ( 1 ) page: 15 - 21   2020.8

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    Authorship:Last author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  5. 【造血器腫瘍学(第2版)-基礎と臨床の最新研究動向-】造血器腫瘍の診断と治療 治療法 分子標的療法(TKI、エピジェネティック修飾、PI、IMiDs含む) Invited

    石川裕一、清井仁

    日本臨床   Vol. 78   page: 233 - 238   2020.8

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  6. 造血器腫瘍の病態に基づいた新規治療薬の選択】再発・難治性のB細胞性急性リンパ性白血病に対する二重特異性T細胞誘導(BiTE)抗体ブリナツモマブ Invited

    川島直実、清井仁

    血液内科   Vol. 81 ( 1 ) page: 30 - 34   2020.7

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  7. 【病気とくすり2020 基礎と実践Expert's Guide】病原微生物・悪性新生物とくすり 悪性腫瘍 白血病 Invited

    中島 麻梨絵, 石川 裕一, 清井 仁

    薬局   Vol. 71 ( 4 ) page: 2061 - 2069   2020.3

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    Authorship:Last author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  8. 【病気とくすり2020 基礎と実践Expert's Guide】病原微生物・悪性新生物とくすり 悪性腫瘍 悪性リンパ腫 Invited

    村瀬 篤史, 島田 和之, 清井 仁

    薬局   Vol. 71 ( 4 ) page: 2070 - 2077   2020.3

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    Authorship:Last author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  9. 【病気とくすり2020 基礎と実践Expert's Guide】病原微生物・悪性新生物とくすり 悪性腫瘍 多発性骨髄腫 Invited

    牛島洋子、清井仁

    薬局   Vol. 71 ( 4 ) page: 2070 - 2077   2020.3

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  10. 【急性白血病-最新の診断と治療-】開発中の薬剤 FLT3阻害薬 Invited

    川島直実、清井仁

    日本臨床   Vol. 78 ( 3 ) page: 499 - 506   2020.3

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  11. 【白血病治療薬開発の現況】FLT3阻害薬 Invited

    清井仁

    医学と薬学   Vol. 77 ( 2 ) page: 205 - 211   2020.1

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Presentations 41

  1. Favorable Outcomes of Newly Diagnosed Intravascular Large B-Cell Lymphoma Patients Treated with R-CHOP Combined with High-Dose Methotrexate Plus Intrathecal Chemotherapy: Results from a Multicenter Phase 2 Trial (PRIMEUR-IVL) International conference

    Shimada Kazuyuki, Yamaguchi Motoko, Atsuta Yoshiko, Matsue Kosei, Sato Keijiro, Kusumoto Shigeru, Nagai Hirokazu, Takizawa Jun, Fukuhara Noriko, Nagafuji Koji, Miyazaki Kana, Ohtsuka Eiichi, Okamoto Masataka, Sugita Yasumasa, Uchida Toshiki, Kayukawa Satoshi, Wake Atsushi, Ennishi Daisuke, Kondo Yukio, Izumi Tohru, Kin Yoshihiro, Tsukasaki Kunihiro, Hashimoto Daigo, Yuge Masaaki, Yanagisawa Atsumi, Kuwatsuka Yachiyo, Shimada Satoko, Masaki Yasufumi, Niitsu Nozomi, Kiyoi Hitoshi, Suzuki Ritsuro, Tokunaga Takashi, Nakamura Shigeo, Kinoshita Tomohiro

    American Society of Hematology Annual meeting  2019.11.13 

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    Event date: 2020.12

    Language:English   Presentation type:Oral presentation (general)  

  2. Dynamics of Genetic Landscapes and Clonal Evolution between Patients and PDX Models in Acute Myeloid Leukemia International conference

    Kawashima Naomi, Ishikawa Yuichi, Akashi Akimi, Hattori Hikaru, Yamaguchi Yohei, Nishiyama Takahiro, Kihara Rika, Ozawa Yukiyasu, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2018.11.29 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

  3. NDRG2はびまん性大細胞型B細胞リンパ腫の中枢神経病変において高発現を来す

    村瀨篤史、島田和之、青木智広、真田昌、中杤昌弘、島田聡子、久納俊祐、中村栄男、清井仁

    第82回日本血液学会学術集会  2020.10.10 

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国立京都国際会館およびWeb開催   Country:Japan  

  4. Assessment of optimal introduction ratio of CD3z-based artificial T cell activating molecule to TCR.

    Sakai T, Terakura S, Okuno S, Miyao K, Hamana H, Kishi H, Nishida T, Murata M, Kiyoi H.

    2020.10.10 

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  5. Optimization of antigen recognition in the development of anti-CD37 chimeric antigen receptor T cell

    Okuno S, Adachi Y, Terakura S, Julamanee J, Sakai T, Nishida T, Murata M, Kiyoi H.

    2020.10.10 

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  6. Comparison of drug sensitivity and resistance to FLT3 inhibitors in FLT3 mutated AML-PDX models

    2020.10.10 

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  7. Upregulation of adhesion molecules associates with PDX-specific clonal expansion and R/R AML.

    2020.10.10 

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  8. Phase I study of cord blood transplantation with intra-bone marrow injection of MSC.

    Goto T, Murata M, Nishida T, Terakura S, Kamoshita S, Ishikawa Y, Ushijima Y, Adachi Y, Kato K, Hirakawa A, Nishiwaki S, Nishio N, Takahashi Y, Kodera Y, Matsushita T, Kiyoi H.

    2020.10.10 

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  9. Efficacy of a novel anti-transferrin antibody, TSP-A74, in the treatment of AML.

    中島 麻梨絵、石川 裕一、大平 悠太、鵜飼 由範、金 貞姫、川島 直実、牛島 洋子、松浦 正、清井 仁

    第82回日本血液学会学術集会  2020.10.10 

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国立京都国際会館およびWeb開催   Country:Japan  

  10. Exosomes derived from cancer associated fibroblasts induce a resistance to histone deacetylase inhibitors in lymphoma.

    加賀谷裕介、島田和之、久納俊祐、疋田智也、青木智広、坂本明彦、早川文彦、小根山千歳、清井仁.

    第79回日本癌学会学術総会  2020.10.1 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:リーガロイヤルホテル広島/メルパルク広島およびWeb開催   Country:Japan  

  11. 遺伝子改変CD3z人工アダプター分子のTCRに対する至適遺伝子導入比率の検討

    堺 寿保, 寺倉精太郎, 奥野真吾, 宮尾康太郎, 浜名 洋, 岸 裕幸, 西田徹也, 村田 誠, 清井 仁

    第12回日本血液疾患免疫療法学会学術集会  2020.9.12 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千里ライフサイエンスセンターおよびweb開催   Country:Japan  

  12. 間葉系幹細胞の骨髄内輸注を併用する臍帯血移植に関する臨床第I相試験

    後藤辰徳, 村田 誠, 西田徹也, 寺倉精太郎, 鴨下園子, 石川裕一, 牛島洋子, 足立佳也, 加藤勝義, 平川晃弘, 西脇聡史, 西尾信博, 高橋義行, 小寺良尚, 松下 正, 清井 仁

    第12回日本血液疾患免疫療法学会学術集会  2020.9.12 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千里ライフサイエンスセンターおよびweb開催   Country:Japan  

  13. Low-factor consumption and cost effectiveness for surgeries in hemophilia B patients with N9-GP International conference

    International Society on Thrombosis and Haematosis 2020  2020.7.11 

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    Event date: 2020.7

    Language:English   Presentation type:Poster presentation  

    Venue:Web  

  14. ndothelial colony forming cells (ECFCs) 樹立法の標準化への試み

    岡本修一、 鈴木伸明、 兼松毅、 鈴木敦夫、 大平晃也、 所真昼、 早川友梨、 田村彰吾、 早川文彦、 清井仁、 小嶋哲人、 松下正

    第42回日本血栓止血学会  2020.6.20 

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    Event date: 2020.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪   Country:Japan  

  15. The Optimal Treatment Strategy for Adult Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Complete Remission in the Era of High-Intensity Chemotherapy International conference

    Kako Shinichi, Hayakawa Fumihiko, Imai Kiyotoshi, Tanaka Junji, Mizuta Shuichi, Nishiwaki Satoshi, Kanamori Heiwa, Doki Noriko, Uchida Naoyuki, Ikegame Kazuhiro, Fukuda Takahiro, Ichinohe Tatsuo, Ota Shuichi, Tanaka Yoshinori, Murayama Tohru, Kurahashi Shingo, Sakura Toru, Usui Noriko, Ohtake Shigeki, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Atsuta Yoshiko

    American Society of Hematology Annual meeting  2019.11.13 

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  16. Phase I Study of Cord Blood Transplantation with Intra-Bone Marrow Injection of Mesenchymal Stem Cells International conference

    Goto Tatsunori, Murata Makoto, Nishida Tetsuya, Terakura Seitaro, Kamoshita Sonoko, Ishikawa Yuichi, Ushijima Yoko, Adachi Yoshiya, Kato Katsuyoshi, Hirakawa Akihiro, Nishiwaki Satoshi, Nishio Nobuhiro, Takahashi Yoshiyuki, Kodera Yoshihisa, Matsushita Tadashi, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2019.11.13 

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  17. Prospective Comparison of Azacitidine Treatment between 7-Days and 5-Days Schedules for Patients with Higher-Risk Myelodysplastic Syndromes; Results of Japan Adult Leukemia Study Group MDS212 Trial International conference

    Kiguchi Toru, Sato Shinya, Usuki Kensuke, Ishiyama Ken, Ito Yoshikazu, Suzuki Takahiro, Taguchi Jun, Chiba Shigeru, Dobashi Nobuaki, Tomita Akihiro, Harada Hironori, Handa Hiroshi, Horiike Shigeo, Maeda Tomoya, Matsuda Mitsuhiro, Ichikawa Motoshi, Hata Tomoko, Honda Sumihisa, Iyama Satoshi, Suzushima Hitoshi, Moriuchi Yukiyoshi, Kurokawa Toshiro, Yamauchi Takahiro, Kiyoi Hitoshi, Naoe Tomoki, Miyazaki Yasushi

    American Society of Hematology Annual meeting  2019.11.13 

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    Event date: 2019.12

    Language:English   Presentation type:Oral presentation (general)  

  18. Prospective Evaluation of Allogeneic HSCT at the First Remission for Younger Adults with FLT3-ITD Positive Acute Myeloid Leukemia: The JALSG AML209-FLT3-SCT Study International conference

    Kawashima Naomi, Ishikawa Yuichi, Atsuta Yoshiko, Sawa Masashi, Ozawa Yukiyasu, Hayashi Masaki, Kohno Akio, Tomita Akihiro, Maeda Tomoya, Sakaida Emiko, Usuki Kensuke, Hagihara Maki, Kanamori Heiwa, Matsuoka Hiroshi, Kobayashi Miki, Asou Norio, Ohtake Shigeki, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2019.11.13 

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  19. Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells International conference

    Tange Naoyuki, Hayakawa Fumihiko, Yasuda Takahiko, Yamamoto Hideyuki, Hirano Daiki, Tsuzuki Shinobu, Kiyoi Hitoshi

    2019.11.13 

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  20. Guided Polarization of iPSC-Derived CD4SP Helper T Cells By CRISPR/Cas9-Based Genome-Editing International conference

    Yano Hisashi, Shinohara Tokuyuki, Koga Keiko, Iriguchi Shoichi, Miyake Yasuyuki, Song Xuewei, Tada Megumi, Kassai Yoshiaki, Kiyoi Hitoshi, Kaneko Shin

    American Society of Hematology Annual meeting  2019.11.13 

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  21. FF-10101 Retains Potent Inhibitory Activities Against Resistant Mutations to FLT3 Inhibitors, Newly Identified in Random Mutagenesis Screens International conference

    Ishikawa Yuichi, Saito Koichi, Kawashima Naomi, Morimoto Michie, Murao Hidetoshi, Terada Daisuke, Yamaura Takeshi, Hagiwara Shinji, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2019.11.13 

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  22. Efficacy and Safety of Blinatumomab in Asian Adults with Relapsed/Refractory B-Precursor ALL International coauthorship International conference

    Kobayashi Yukio, Oh Iekuni, Miyamoto Toshihiro, Lee Won-Sik, Iida Hiroatsu, Minami Hironobu, Maeda Yoshinobu, Jang Jun Ho, Yoon Sung-Soo, Yeh Su-Peng, Qui Tran, Morris Joan, Franklin Janet L., Chong Ka-Wing, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2019.11.13 

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  23. Development of Predictive Biomarker and Optimal Treatment Strategy with FLT3 Inhibitors in Acute Myeloid Leukemia International conference

    Kim Jeong Hui, Harada Yasuhiko, Ishikawa Yuichi, Kawashima Naomi, Nakashima Marie, Ushijima Yoko, Nishiyama Takahiro, Goto Tatsunori, Fukushima Nobuaki, Kihara Rika, Kajiguchi Tomohiro, Watamoto Koichi, Kohno Akio, Kitamura Kunio, Ozawa Yukiyasu, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2019.11.13 

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  24. Discovery of a Novel Dihydroorotate Dehydrogenase Inhibitor That Induces Differentiation and Overcomes Ara-C Resistance of Acute Myeloid Leukemia Cells International conference

    Kitazawa Satoshi, Ishii Yukiko, Makita-Suzuki Keiko, Saito Koichi, Takayanagi Kensuke, Sugihara Hiromi, Matsuda Shun, Yamakawa Takayuki, Tsutsui Yasuhiro, Tanaka Tadashi, Hatta Tomohisa, Natsume Tohru, Kondo Toru, Ishikawa Yuichi, Hagiwara Shinji, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2019.11.13 

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  25. Prospective Evaluation of Prognostic Relevance of KIT Mutations in Core-Binding Factor Acute Myeloid Leukemia: Results from the JALSG CBF-AML209-KIT Study International conference

    Kawashima Naomi, Ishikawa Yuichi, Atsuta Yoshiko, Sugiura Isamu, Sawa Masashi, Dobashi Nobuaki, Yokoyama Hisayuki, Doki Noriko, Tomita Akihiro, Kiguchi Toru, Koh Shiro, Kanamori Heiwa, Iriyama Noriyoshi, Kohno Akio, Moriuchi Yukiyoshi, Asada Noboru, Hirano Daiki, Togitani Kazuto, Sakura Toru, Hagihara Maki, Tomikawa Tatsuki, Yokoyama Yasuhisa, Asou Norio, Ohtake Shigeki, Matsumura Itaru, Miyazaki Yasushi, Naoe Tomoki, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2018.11.29 

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    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (general)  

  26. Phase 2 Study of Blinatumomab in Japanese Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia (R/R ALL) International coauthorship International conference

    Kobayashi Yukio, Zimmerman Zachary F., Oh Iekuni, Maeda Yoshinobu, Minami Hironobu, Miyamoto Toshihiro, Sakura Toru, Iida Hiroatsu, Chen Yuqi, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2018.11.29 

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

  27. Genomic and Clinical Characterization of Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia International conference

    Yasuda Takahiko, Nishijima Dai, Kojima Shinya, Kawazu Masahito, Ueno Toshihide, Tsuzuki Shinobu, Kiyoi Hitoshi, Matsumura Itaru, Miyazaki Yasushi, Horibe Keizo, Mano Hiroyuki, Naoe Tomoki, Sanada Masashi, Hayakawa Fumihiko

    American Society of Hematology Annual meeting  2018.11.29 

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

  28. Exosomes Derived from Cancer Associated Fibroblasts Elicit Survival and Drug Resistance of Primary Lymphoma Cells International conference

    Kunou Shunsuke, Shimada Kazuyuki, Hikita Tomoya, Aoki Tomohiro, Sakamoto Akihiko, Hayakawa Fumihiko, Oneyama Chitose, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2018.11.29 

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

  29. Combining the Number of Infectious Episodes and Interval of Chemotherapy to Transplantation May Predict a Transplant Outcome in Patients with Acute Myeloid Leukemia: A Retrospective Analysis of JALSG AML201 Study International conference

    Kaito Satoshi, Doki Noriko, Najima Yuho, Ohtake Shigeki, Kiyoi Hitoshi, Fujita Hiroyuki, Miyazaki Yasushi, Usui Noriko, Okumura Hirokazu, Miyamura Koichi, Sakaida Emiko, Fujieda Atsushi, Tadashi Nagai, Yamane Takahisa, Kazunori Ohnishi, Naoe Tomoki, Ohashi Kazuteru

    American Society of Hematology Annual meeting  2018.11.29 

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

  30. CD56 Is an Unfavorable Prognostic Factor for Acute Promyelocytic Leukemia: Results By Multivariate Analyses in the JALSG-APL204 Study International conference

    Takeshita Akihiro, Asou Norio, Atsuta Yoshiko, Furumaki Hiroaki, Sakura Toru, Ueda Yasunori, Sawa Masashi, Dobashi Nobuaki, Suzuki Rikio, Taniguchi Yasuhiro, Nakagawa Masaru, Tamaki Shigehisa, Hagihara Maki, Fujimaki Katsumichi, Yokoyama Yasuhisa, Fujita Hiroyuki, Yanada Masamitsu, Maeda Yoshinobu, Usui Noriko, Kobayashi Yukio, Kiyoi Hitoshi, Ohtake Shigeki, Matsumura Itaru, Naoe Tomoki, Miyazaki Yasushi

    American Society of Hematology Annual meeting  2018.11.29 

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

  31. Anti-Leukemic Effect of Retinoic Acid in Non-APL AML Cells International conference

    Harada Yasuhiko, Ishikawa Yuichi, Kawashima Naomi, Hattori Hikaru, Yamaguchi Yohei, Adachi Yoshiya, Ushijima Yoko, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2018.11.29 

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

  32. ZNF384-Fusion Proteins Have High Affinity to EP300, Which Increases Their Transcriptional Activities International conference

    Yamamoto Hideyuki, Hayakawa Fumihiko, Yasuda Takahiko, Minamikawa Yuka, Tange Naoyuki, Hirano Daiki, Kojima Yuki, Morishita Takanobu, Tsuzuki Shinobu, Mano Hiroyuki, Naoe Tomoki, Kiyoi Hitoshi

    American Society of Hematology Annual meeting  2018.11.29 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  33. The Presence of Defective Epstein-Barr Virus (EBV) Infection in Patients with EBV-Associated Hematological Malignancy International conference

    Okuno Yusuke, Murata Takayuki, Sato Yoshitaka, Muramatsu Hideki, Ito Yoshinori, Watanabe Takahiro, Okuno Tatsuya, Murakami Norihiro, Yoshida Kenichi, Sawada Akihisa, Inoue Masami, Kawa Keisei, Seto Masao, Ohshima Koichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Narita Yohei, Yoshida Masahiro, Goshima Fumi, Kawada Junichi, Nishida Tetsuya, Kiyoi Hitoshi, Kato Seiichi, Nakamura Shigeo, Morishima Satoko, Fujiwara Shigeyoshi, Shimizu Norio, Isobe Yasushi, Noguchi Masaaki, Kikuta Atsushi, Iwatsuki Keiji, Takahashi Yoshiyuki, Kojima Seiji, Ogawa Seishi, Kimura Hiroshi

    American Society of Hematology Annual meeting  2018.11.29 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  34. 造血器腫瘍診療における遺伝子検査の必要性

    清井 仁

    第25回日本臨床化学会東海・北陸支部総会 第33回日本臨床検査医学会東海・北陸支部例会 

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    Event date: 2014.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋   Country:Japan  

  35. 活性型変異FLT3を標的とした白血病治療の現状と課題

    清井 仁

    第23回日本Cell Death学会学術集会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  36. Comprehensive Analysis of Genetic Alterations and Their Prognostic Impacts in Adult Acute Myeloid Leukemia Patients Treated with the Japan Adult Leukemia Study

    Hitoshi Kiyoi, RiKa Kihara,Yasunobu Nagata, Seishi Ogawa,Tomoki Naoe.

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    Event date: 2014.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  37. Prognostic impacts and clonal heterogeneity of recurrently identified mutations in AML International conference

    Hitoshi Kiyoi and Tomoki Naoe

    XXVI Symposium IACRLRD International Association for Comparative Research on Leukemia and Related Diseases 

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    Event date: 2013.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Italy  

  38. 急性骨髄性白血病における分子標的治療薬の開発

    清井 仁

    第54回日本小児血液・がん学会学術集会 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  39. 白血病治療の現状と将来

    清井 仁

    第50回日本癌治療学会総会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  40. AML病態研究の進展と最近の治療エビデンス

    清井 仁

    第73回日本血液学会学術集会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋   Country:Japan  

  41. Exosomes derived from cancer associated fibroblasts induce a resistance to histone deacetylase inhibitors in lymphoma

    Kagaya Yusuke, Shimada Kazuyuki, Kunou Shunsuke, Hikita Tomoya, Sakamoto Akihiko, Hayakawa Fumihiko, Oneyama Chitose, Kiyoi Hitoshi

    CANCER SCIENCE  2021.2 

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    Language:Japanese   Presentation type:Poster presentation  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 34

  1. PDX治療モデルを併用した治療抵抗性急性骨髄性白血病クローンの成立過程に生じる分子病態に基づく層別化システムの確立と標的治療薬開発に関する研究

    Grant number:20ck0106535h0001  2020.4 - 2023.3

    革新的がん医療実用化研究事業 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\24580000 ( Direct Cost: \19000000 、 Indirect Cost:\5580000 )

  2. 骨髄系腫瘍における難治性クローンへの進展・選択過程に生じる分子病態の解明

    2019.8 - 2021.3

    次世代がん医療創生研究事業 

    清井 仁

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    Grant type:Competitive

  3. 造血器腫瘍における遺伝子パネル検査の提供体制構築およびガイドライン作成に資する研究

    2020.7 - 2020.3

    厚生労働科学研究費 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\650000 ( Direct Cost: \500000 、 Indirect Cost:\150000 )

  4. t(8;21)およびinv(16)陽性AYA・若年成人急性骨髄性白血病に対する微小残存病変を指標とするゲムツズマブ・オゾガマイシン治療介入の有効性と安全性を評価する研究

    2020.4 - 2023.3

    革新的がん医療実用化研究事業 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\2340000 ( Direct Cost: \1800000 、 Indirect Cost:\540000 )

  5. AYA世代および成人T細胞性急性リンパ性白血病の小児型治療適用における限界年齢と新規バイオマーカー探索に関する研究

    2020.4 - 2023.3

    日本医療研究開発機構  革新的がん医療実用化事業 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  6. 末治療血管内大細胞型B細胞リンパ腫に対する治療研究

    2019.4 - 2022.3

    革新的がん医療実用化事業 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  7. 慢性骨髄性白血病患者における第二世代チロシンキナーゼ阻害薬の中止後の無治療寛解の評価と最適化

    2018.4 - 2021.3

    革新的がん医療実用化研究事業 

    松村 到

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  8. 急性骨髄性白血病におけるPDXモデルで意義づけられた分子層別化システムの確立と臨床的実効性と有用性の検証

    2017.4 - 2020.3

    革新的がん医療実用化研究事業 

    清井 仁

      More details

    Authorship:Principal investigator  Grant type:Competitive

  9. AYA世代急性リンパ性白血病の小児型治療法および遺伝子パネル診断による層別化治療に関する研究

    2017.4 - 2020.3

    革新的がん医療実用化研究事業 

    早川文彦

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    Grant type:Competitive

  10. がん領域における臨床ゲノム情報データストレージの整備に関する研究

    2016.9 - 2019.3

    臨床ゲノム情報統合データベース整備事業 

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    Grant type:Competitive

  11. PDXモデルおよび網羅的遺伝子変異解析による新規非可逆的結合型FLT3阻害剤の臨床的有効性を予測するバイオマーカーと至適併用療法の確立

    2016.8 - 2019.3

    日本白血病研究基金 

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    Grant type:Competitive

  12. マルチプレックスPCR法を用いた造血幹細胞移植後の重症ウイルス感染症早期診断法実用化研究

    2016

    橋渡し研究加速ネットワークプログラム 

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    Grant type:Competitive

  13. AYA世代急性リンパ性白血病の発症機構解明と治療標的の同定

    2015.4 - 2018.3

    革新的がん医療実用化研究事業 

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    Grant type:Competitive

  14. チロシンキナーゼ阻害薬による慢性骨髄性白血病の治癒を目指した研究

    2015.4 - 2018.3

    革新的がん医療実用化研究事業 

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    Grant type:Competitive

  15. 既存治療薬抵抗性FLT3変異を有する再発・難治性の急性骨髄性白血病に対する治療薬

    2015 - 2018

    産学共同実用化開発事業 

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    Grant type:Competitive

  16. 再発・難治性造血器腫瘍の単一細胞レベルでの分子病態に基づく薬剤耐性クローンの解析と治療標的の同定

    2014 - 2016

    東京生化学研究会助成金 

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    Grant type:Competitive

  17. がん治療後に発症する二次性白血病の分子病態の解明

    2014 - 2015

    上原記念生命科学財団研究助成金 

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    Grant type:Competitive

  18. リガンド依存性耐性機構の克服による効果的受容体型チロシンキナーゼ阻害剤療法の開発

    2012.6 - 2013.5

    小林がん学術振興会研究助成金 

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    Grant type:Competitive

  19. 白血病ゲノムに基づく層別化治療の確立

    2011.12 - 2016.3

    次世代がん研究推進プロジェクト 

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    Grant type:Competitive

  20. 新規マルチキナーゼ阻害剤KW-2449の有効性を予測するサロゲートマーカーの確立

    2009.4 - 2010.3

    北村記念血液疾患研究基金 

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    Grant type:Competitive

  21. 変異チロシンキナーゼを標的とした白血病治療薬の開発

    2005.4 - 2010.3

    独立行政法人医薬基盤研究所 保健医療分野における基礎研究推進事業 

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    Grant type:Competitive

  22. 急性骨髄性白血病に高頻度で認められるFLT3遺伝子変異を分子標的とした治療法の開発

    2001.4 - 2002.3

    教育研究拠点形成支援経費 生体複雑系の4次元分子論的解析と臨床医学・教育への応用 

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    Grant type:Competitive

  23. 急性骨髄性白血病におけるFLT3遺伝子変異とその意義

    2001.4 - 2001.3

    白血病研究基金 

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    Grant type:Competitive

  24. FLT3遺伝子キナーゼ領域における点突然変異の生物学的意義の解析

    2000.4 - 2001.3

    ノバルティス研究奨励金 

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    Grant type:Competitive

  25. 変異FLT3分子シグナルがもたらす細胞増殖・分化の脱制御機構の解析

    2000.4 - 2001.3

    東海学術奨励会 

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    Grant type:Competitive

  26. 変異FLT3分子シグナルがもたらす細胞増殖・分化の脱制御機構の解析

    1999.4 - 2000.3

    武田科学振興財団一般研究奨励金 

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    Grant type:Competitive

  27. 急性骨髄性白血病の発生・進展に関与する変異FLT3分子を標的とした新化学療法剤の開発

    1999.4 - 2000.3

    興和生命科学振興財団 

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    Grant type:Competitive

  28. 急性骨髄性白血病の発生・進展に関与する変異FLT3分子を標的とした新化学療法剤の開発

    1999.4 - 2000.3

    持田記念医学薬学振興財団 

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    Grant type:Competitive

  29. 急性骨髄性白血病におけるFLT3遺伝子異常のもたらす細胞増殖促進機構の解明

    1998.4 - 1999.3

    愛知県がん研究振興会 がんその他の悪性新生物研究助成金 

      More details

    Grant type:Competitive

  30. ヒト白血病細胞における受容体型チロシンキナーゼFLT3遺伝子変異の生物学的意義

    1997.4 - 1998.3

    原口記念癌研究助成基金 

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    Grant type:Competitive

  31. ヒト白血病における受容体型チロシンキナーゼFLT3遺伝子変異がおよぼす細胞増殖シグナル伝達機構の解明

    1997.4 - 1998.3

    大阪癌研究会 一般学術研究助成金 

      More details

    Grant type:Competitive

  32. ヒト白血病細胞における受容体型チロシンキナーゼFLT3遺伝子変異がおよぼす細胞増殖シグナル伝達機構の解明

    1997.4 - 1998.3

    上原記念生命科学財団 研究奨励金 

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    Grant type:Competitive

  33. ヒト白血病細胞における受容体型チロシンキナーゼFLT3遺伝子変異の生物学的意義

    1997.4 - 1998.3

    かなえ医薬振興財団 

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    Grant type:Competitive

  34. 免疫グロブリン重鎖超可変部領域遺伝子転写産物の構造より見たB細胞分化のメカニズムの解析

    1996.4 - 1997.3

    日比野医学研究基金 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 23

  1. Molecular pathologic elucidation to become usefulness and the choice grounds of the novel FLT3 inhibitor

    Grant number:17K09921  2017.4 - 2020.3

    Kiyoi Hitoshi

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    We established several PDX models from FLT3 mutation-positive AML cells. Using these PDX models, we analyzed the molecular pathology of AML cells remaining after treatment with quizartinib and gilteritinib, and revealed that AML clones, which express high wild type FLT3 molecules in addition to mutant FLT3 molecules, selectively remained. When the growth inhibitory activities of clinical samples with different expression levels of normal FLT3 molecules were compared, the inhibitory effect was associated with the expression level of normal FLT3 molecules.
    We created a model for FLT3 inhibitor resistance in 32D cells transfected with various mutant FLT3s, and identified several novel mutations in the FLT3 kinase domain and the existence of cross-resistance to other FLT3 inhibitors.

  2. 全例登録を基盤とした高リスク骨髄異形成症候群に対する標準治療の確立および予後マーカー探索の研究

    2013.4 - 2016.3

    科学研究費補助金  厚生労働科学研究費補助金・がん臨床研究事業

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    Authorship:Coinvestigator(s) 

  3. 創薬に向けた白血病のトランスレーショナルリサーチ

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

  4. 成人難治性白血病におけるバイオマーカーに基づく層別化治療法の確立

    2013.4 - 2014.3

    科学研究費補助金  厚生労働科学研究費補助金・がん臨床研究事業

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    Authorship:Coinvestigator(s) 

  5. 難治性白血病に対する標準的治療法の確立に関する研究

    2013.4 - 2014.3

    科学研究費補助金  国立がん研究センター運営費交付金研究開発費

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    Authorship:Coinvestigator(s) 

  6. 高齢者造血器障害における層別化治療を目指した分子疫学的研究

    2013.4 - 2014.3

    科学研究費補助金  長寿医療研究開発費

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    Authorship:Coinvestigator(s) 

  7. リガンド依存性受容体型チロシンキナーゼ阻害剤耐性機構の解明と克服

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  8. 高齢者造血障害に関する分子疫学的検討のための基盤整備

    2010.7 - 2011.3

    科学研究費補助金  平成22年度長寿医療研究開発費

    勝見 章

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    Authorship:Coinvestigator(s) 

  9. FLT3分子の糖鎖修飾と細胞内局在に基づく標的阻害効果増強法の検討

    2009.4 - 2012.3

    科学研究費補助金  科学研究費補助金(基盤研究(C))・21591198

    清井 仁

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    Authorship:Principal investigator 

  10. キナーゼ阻害剤感受性パネルに基づく白血病の層別化

    2008.4 - 2010.3

    科学研究費補助金  特定領域研究,課題番号:20014008

    清井 仁

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    Authorship:Principal investigator 

  11. 多施設共同研究に登録された白血病の検体収集と中央保存システムの確立

    2007.4 - 2010.3

    科学研究費補助金  厚生労働科学研究費補助金(創薬基盤推進研究事業:生物資源研究)

    直江知樹

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    Authorship:Coinvestigator(s) 

  12. 成人難治性白血病の分子生物学的特徴に基づく治療法に関する研究

    2007.4 - 2009.3

    科学研究費補助金  厚労省がん研究助成金

    朝長万左男

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    Authorship:Coinvestigator(s) 

  13. 白血病の発症、進展に及ぼすNucleophosmin遺伝子変異の分子機構の解析

    2006.4 - 2008.3

    科学研究費補助金  基盤研究(C)

    清井 仁

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    Authorship:Principal investigator 

  14. チロシンキナーゼ阻害剤の至適併用療法を予測するサロゲートマーカーの確立

    2006.4 - 2008.3

    科学研究費補助金  特定領域研究、18014010

    清井 仁

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    Authorship:Principal investigator 

  15. 白血病細胞の分化を抑制する転写抑制因子複合体の解析と新規分化誘導療法の開発

    2005.4 - 2007.3

    科学研究費補助金  文部科学省 基盤研究(C)

    冨田章裕

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    Authorship:Coinvestigator(s) 

  16. チロシンキナーゼ阻害剤の感受性を予測するサロゲートマーカーの確立

    2005.4 - 2006.3

    科学研究費補助金  特定領域研究,課題番号:17015021

    清井 仁

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    Authorship:Principal investigator 

  17. 造血器腫瘍における異常シグナル伝達の解析と治療法の開発

    2004.4 - 2007.3

    科学研究費補助金  文部科学省 基盤研究(B)

    直江知樹

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    Authorship:Coinvestigator(s) 

  18. 新規FLT3キナーゼ阻害剤の臨床応用へ向けた基盤的研究と評価モデルマウスの作製

    2004.4 - 2006.3

    科学研究費補助金  基盤研究(C),課題番号:16590932

    清井 仁

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    Authorship:Principal investigator 

  19. 血液細胞由来組織因子の血栓形成における役割-TF低発現・AT欠損マウスによる検討

    2004.4 - 2006.3

    科学研究費補助金  文部科学省 基盤研究(C) (16590933)

    松下 正

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    Authorship:Coinvestigator(s) 

  20. 変異FLT3分子を標的とした新たな白血病治療法開発に向けての基礎的検討

    2002.4 - 2004.3

    科学研究費補助金  基盤研究(C)

    清井 仁

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    Authorship:Principal investigator 

  21. FLT3チロシンキナーゼ遺伝子導入による白血病モデルマウスの樹立

    2001.4 - 2003.3

    科学研究費補助金  文部省科学研究費補助金 基盤研究(C) 13671058

    直江知樹

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  22. 薬物代謝酵素遺伝子多型と発現遺伝子プロファイルによる急性白血病の層別化

    2001.4 - 2002.3

    科学研究費補助金  特定領域研究

    清井 仁

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    Authorship:Principal investigator 

  23. 変異FLT3分子シグナルがもたらす細胞増殖・分化の脱制御機構の解析

    2000.4 - 2002.3

    科学研究費補助金  基盤研究(C)

    清井 仁

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 24

  1. 血液病

    2020

  2. Case Study血液疾患

    2020

  3. 修士課程臨床医学概論

    2020

  4. 血液がん

    2020

  5. 増血総論

    2020

  6. 特徴あるプログラムTRコース

    2020

  7. 産官学連携講座

    2020

  8. 医学入門

    2020

  9. 血液・腫瘍内科学実験研究

    2020

  10. 血液・腫瘍内科学セミナー

    2020

  11. 特徴あるプログラム トランスレーショナルリサーチコース

    2020

  12. 特徴あるプログラム 産官学連携プログラム

    2020

  13. 血液病

    2016

  14. 血液・腫瘍内科学

    2015

  15. 生涯健康と医学

    2015

  16. 修士課程医科学専攻 臨床医学概論

    2015

  17. 造血器腫瘍学 -最新の診断と治療-

    2015

  18. 血液病

    2015

  19. 造血器腫瘍学 -最新の診断と治療-

    2014

  20. 生涯健康と医学

    2014

  21. 修士課程医科学専攻 臨床医学概論

    2014

  22. 血液病

    2014

  23. 血液学

    2012

  24. 感染症

    2011

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Academic Activities 4

  1. 日本臨床腫瘍学会 International contribution

    Role(s):Panel moderator, session chair, etc.

    2021.1

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    Type:Academic society, research group, etc. 

  2. 日本血液学会学術・統計調査委員会 International contribution

    Role(s):Planning/Implementing academic research

    日本血液学会  2020.10

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    Type:Academic research 

  3. 日本血液学会学術集会 International contribution

    Role(s):Planning, management, etc., Panel moderator, session chair, etc., Peer review

    日本血液学会  2020.10

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    Type:Academic society, research group, etc. 

  4. JALSG International contribution

    Role(s):Planning, management, etc.

    JALSG  2015.6