Faculty Profiles - ISHIGURO, Hiroshi

Papers - ISHIGURO, Hiroshi

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Predictability of the national psychological stress screening for subsequent long-term psychiatric sick leave among employees: A multicenter nested case-control study. Reviewed

Kawamura T, Kobayashi D; University Network Analyses of Stress Check for Employees (UNASCE) investigators.

J Occup Environ Med Vol. 66 ( 5 ) page： 433 - 438 2024.5

「特集」希少肺疾患はどこまで解明されたか？　嚢胞性線維症 Invited

石黒　洋、藤木理代、中莖みゆき、小澤祐加、近藤志保、山口　誠、谷口いつか、野村奈央、古橋（樋口）万佑子、丹羽永理奈、佐藤鈴菜、相馬義郎、成瀬　達、山本明子

呼吸器内科 Vol. 45 ( 4 ) page： 391 - 397 2024.4

名古屋大学生協におけるハラルメニュー提供の現状と給食における多様性対応への一考察 Reviewed Open Access

持丸由香、山本明子、石黒　洋

総合保健体育科学 Vol. 46 ( 1 ) page： 60 - 67 2023

膵導管細胞の病態生理と嚢胞性線維症 Invited Reviewed

石黒　洋、山口　誠、山本明子

胆と膵 Vol. 43 ( 8 ) page： 743 - 750 2022.8

Focal biliary cirrhosisと門脈圧亢進症をともなう嚢胞性線維症の1例 Reviewed Open Access

山本明子、伊藤孝一、成瀬　達、服部日出夫、中莖みゆき、藤木理代、石黒　洋

日本消化器病学会雑誌 Vol. 118 ( 7 ) page： 686 - 697 2021.7

Regulation of Pancreatic Fluid and Electrolyte Secretion Invited Reviewed

Ishiguro H, Yamaguchi M, Yamamoto A

Pacreapedia: Exocrine Pancreas Knowledge Base page： 1 - 13 2021.3

健康白書の意義 Reviewed Open Access

石黒　洋

Vol. 57 ( 2 ) page： 2 - 4 2020.6

大学生の定期健康診断における尿検査の意義と課題 Reviewed Open Access

小澤祐加、石黒　洋、守山敏樹、鈴木芳樹

Vol. 57 ( 2 ) page： 23 - 29 2020.6

大学生の肝機能とBMI Reviewed Open Access

山本明子、石黒　洋

Vol. 57 ( 2 ) page： 30 - 36 2020.6

CLINICAL ASSESSMENT ON THE SEVERITY OF THE LUNG DISEASE IN YOUNG INDIVIDUALS WITH CYSTIC FIBROSIS IN JAPAN

Yoshimura Kunihiko, Kasagi Satoshi, Ishiguro Hiroshi, Naruse Satoru

RESPIROLOGY Vol. 24 page： 76 - 76 2019.11

Characterization of (G970-T1122)-CFTR, the most frequent CFTR mutant identified in Japanese cystic fibrosis patients Open Access

Wakabayashi-Nakao Kanako, Yu Yingchun, Nakakuki Miyuki, Hwang Tzyh-Chang, Ishiguro Hiroshi, Sohma Yoshiro

JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 69 ( 1 ) page： 103-112 2019.1

Incidence of Cystic Fibrosis in Japanese

Naruse S., Ishiguro H., Yamamoto A., Nakakuki M., Ozawa Y., Taniguchi I., Kondo S., Fujiki K., Futakuchi S., Takeyama Y.

PANCREAS Vol. 48 ( 10 ) page： 1497 - 1497 2019

Genetics and Pancreatic Exocrine Status of Cystic Fibrosis Patients in Japan

Kondo S., Fujiki K., Nakakuki M., Yamamoto A., Kozawa Y., Takeyama Y., Naruse S., Ishiguro H.

PANCREAS Vol. 48 ( 10 ) page： 1465 - 1466 2019

Comparison of Pancreatic Exocrine Status Between Patients With Cystic Fibrosis in Pediatric and Adult Age in Japan

Fujiki K., Kondo S., Nakakuki M., Kozawa Y., Yamamoto A., Takeyama Y., Naruse S., Ishiguro H.

PANCREAS Vol. 48 ( 10 ) page： 1427 - 1427 2019

Clinical Characteristics, Prognosis, and CFTR Mutations of Cystic Fibrosis in Japan

Ishiguro H., Yamamoto A., Fujiki K., Nakakuki M., Taniguchi I., Kozawa Y., Sohma Y., Naruse S., Takeyama Y.

PANCREAS Vol. 47 ( 10 ) page： 1395-1395 2018

Ethnicity impacts the cystic fibrosis diagnosis: A note of caution Reviewed Open Access

Bosch B, Bilton D, Sosnay P, Raraigh KS, Mak DY, Ishiguro H, Gulmans V, Thomas M, Cuppens H, Amaral M, De Boeck K

J Cyst Fibros Vol. 16 ( 4 ) page： 488 - 491 2017.7

Caffeine inhibits fluid secretion by interlobular ducts from guinea pig pancreas Reviewed

Mochimaru Y, Yamamoto A, Nakakuki M, Yamaguchi M, Taniguchi I, Ishiguro H

Pancreas Vol. 46 ( 4 ) page： 549-556 2017.4

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium Reviewed Open Access

Makoto Yamaguchi, Martin C. Steward, Kieran Smallbone, Yoshiro Sohma, Akiko Yamamoto, Shigeru B. H. Ko, Takaharu Kondo, Hiroshi Ishiguro

JOURNAL OF PHYSIOLOGY-LONDON Vol. 595 ( 6 ) page： 1947 - 1972 2017.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：WILEY

A computational model of guinea-pig pancreatic duct epithelium was developed to determine the transportmechanism by whichHCO(3)(-)ions are secretedat concentrations inexcess of 140mM. Parameters defining the contributions of the individual ion channels and transporters were estimated by least-squares fitting of the model predictions to experimental data obtained from isolated ducts and intact pancreas under a range of experimental conditions. The effects of cAMP-stimulated secretion were well replicated by increasing the activities of the basolateral Na+-HCO(3)(-)cotransporter (NBC1) and apical Cl-/HCO(3)(-)exchanger (solute carrier family 26 member A6; SLC26A6), increasing the basolateral K+ permeability and apical Cl(-)and HCO(3)(-)permeabilities (CFTR), and reducing the activity of the basolateral Cl-/HCO(3)(-)exchanger (anion exchanger 2; AE2). Under these conditions, the model secreted similar to 140 mM HCO(3)(-)at a rate of similar to 3 nl min(-1) mm(-2), which is consistent with experimental observations. Alternative 1: 2 and 1: 1 stoichiometries for Cl-/HCO(3)(-)exchange via SLC26A6 at the apical membrane were able to support a HCO3--rich secretion. Raising the HCO3-/Cl(-)permeability ratio of CFTR from 0.4 to 1.0 had little impact upon either the secreted HCO(3)(-)concentration or the volume flow. However, modelling showed that a reduction in basolateral AE2 activity by similar to 80% was essential in minimizing the intracellular Cl(-)concentration following cAMP stimulation and thereby maximizing the secreted HCO(3)(-)concentration. The addition of a basolateral Na+-K+-2Cl(-)cotransporter (NKCC1), assumed to be present in rat and mouse ducts, raised intracellular Cl- and resulted in a lower secreted HCO3- concentration, as is characteristic of those species. We conclude therefore that minimizing the driving force for Cl- secretion is the main requirement for secreting 140 mM HCO3-.

DOI： 10.1113/JP273306

Web of Science

Characterization of mutant CFTRs identified in Japanese Cystic Fibrosis patients

Nakao Kanako, Ishikura Reona, Nakakuki Miyuki, Yasui Masato, Ishiguro Hiroshi, Masaike Tomoko, Sohma Yoshiro

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 133 ( 3 ) page： S121-S121 2017.3

Evidence-based clinical practice guidelines for chronic pancreatitis 2015 Reviewed Open Access

Ito T, Ishiguro H, Ohara H, Kamisawa T, Sakagami J, Sata N, Takeyama Y, Hirota M, Miyakawa H, Igarashi H, Lee L, Fujiyama T, Hijioka M, Ueda K, Tachibana Y, Sogame Y, Yasuda H, Kato R, Kataoka K, Shiratori K, Sugiyama M, Okazaki K, Kawa S, Tando Y, Kinoshita Y, Watanabe M, Shimosegawa T

J Gastroenterol Vol. 51 ( 2 ) page： 85-92 2016.2

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Papers - ISHIGURO, Hiroshi