Faculty Profiles - ISHIGURO, Hiroshi

Papers - ISHIGURO, Hiroshi

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健康白書の意義 Reviewed

石黒　洋

Vol. 57 ( 2 ) page： 2 - 4 2020.6

CLINICAL ASSESSMENT ON THE SEVERITY OF THE LUNG DISEASE IN YOUNG INDIVIDUALS WITH CYSTIC FIBROSIS IN JAPAN

Yoshimura Kunihiko, Kasagi Satoshi, Ishiguro Hiroshi, Naruse Satoru

RESPIROLOGY Vol. 24 page： 76 - 76 2019.11

Characterization of (G970-T1122)-CFTR, the most frequent CFTR mutant identified in Japanese cystic fibrosis patients

Wakabayashi-Nakao Kanako, Yu Yingchun, Nakakuki Miyuki, Hwang Tzyh-Chang, Ishiguro Hiroshi, Sohma Yoshiro

JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 69 ( 1 ) page： 103-112 2019.1

Incidence of Cystic Fibrosis in Japanese

Naruse S., Ishiguro H., Yamamoto A., Nakakuki M., Ozawa Y., Taniguchi I., Kondo S., Fujiki K., Futakuchi S., Takeyama Y.

PANCREAS Vol. 48 ( 10 ) page： 1497 - 1497 2019

Genetics and Pancreatic Exocrine Status of Cystic Fibrosis Patients in Japan

Kondo S., Fujiki K., Nakakuki M., Yamamoto A., Kozawa Y., Takeyama Y., Naruse S., Ishiguro H.

PANCREAS Vol. 48 ( 10 ) page： 1465 - 1466 2019

Comparison of Pancreatic Exocrine Status Between Patients With Cystic Fibrosis in Pediatric and Adult Age in Japan

Fujiki K., Kondo S., Nakakuki M., Kozawa Y., Yamamoto A., Takeyama Y., Naruse S., Ishiguro H.

PANCREAS Vol. 48 ( 10 ) page： 1427 - 1427 2019

Clinical Characteristics, Prognosis, and CFTR Mutations of Cystic Fibrosis in Japan

Ishiguro H., Yamamoto A., Fujiki K., Nakakuki M., Taniguchi I., Kozawa Y., Sohma Y., Naruse S., Takeyama Y.

PANCREAS Vol. 47 ( 10 ) page： 1395-1395 2018

Ethnicity impacts the cystic fibrosis diagnosis: A note of caution Reviewed

Bosch B, Bilton D, Sosnay P, Raraigh KS, Mak DY, Ishiguro H, Gulmans V, Thomas M, Cuppens H, Amaral M, De Boeck K

J Cyst Fibros Vol. 16 ( 4 ) page： 488 - 491 2017.7

Caffeine inhibits fluid secretion by interlobular ducts from guinea pig pancreas Reviewed

Mochimaru Y, Yamamoto A, Nakakuki M, Yamaguchi M, Taniguchi I, Ishiguro H

Pancreas Vol. 46 ( 4 ) page： 549-556 2017.4

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium Reviewed

Makoto Yamaguchi, Martin C. Steward, Kieran Smallbone, Yoshiro Sohma, Akiko Yamamoto, Shigeru B. H. Ko, Takaharu Kondo, Hiroshi Ishiguro

JOURNAL OF PHYSIOLOGY-LONDON Vol. 595 ( 6 ) page： 1947 - 1972 2017.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：WILEY

A computational model of guinea-pig pancreatic duct epithelium was developed to determine the transportmechanism by whichHCO(3)(-)ions are secretedat concentrations inexcess of 140mM. Parameters defining the contributions of the individual ion channels and transporters were estimated by least-squares fitting of the model predictions to experimental data obtained from isolated ducts and intact pancreas under a range of experimental conditions. The effects of cAMP-stimulated secretion were well replicated by increasing the activities of the basolateral Na+-HCO(3)(-)cotransporter (NBC1) and apical Cl-/HCO(3)(-)exchanger (solute carrier family 26 member A6; SLC26A6), increasing the basolateral K+ permeability and apical Cl(-)and HCO(3)(-)permeabilities (CFTR), and reducing the activity of the basolateral Cl-/HCO(3)(-)exchanger (anion exchanger 2; AE2). Under these conditions, the model secreted similar to 140 mM HCO(3)(-)at a rate of similar to 3 nl min(-1) mm(-2), which is consistent with experimental observations. Alternative 1: 2 and 1: 1 stoichiometries for Cl-/HCO(3)(-)exchange via SLC26A6 at the apical membrane were able to support a HCO3--rich secretion. Raising the HCO3-/Cl(-)permeability ratio of CFTR from 0.4 to 1.0 had little impact upon either the secreted HCO(3)(-)concentration or the volume flow. However, modelling showed that a reduction in basolateral AE2 activity by similar to 80% was essential in minimizing the intracellular Cl(-)concentration following cAMP stimulation and thereby maximizing the secreted HCO(3)(-)concentration. The addition of a basolateral Na+-K+-2Cl(-)cotransporter (NKCC1), assumed to be present in rat and mouse ducts, raised intracellular Cl- and resulted in a lower secreted HCO3- concentration, as is characteristic of those species. We conclude therefore that minimizing the driving force for Cl- secretion is the main requirement for secreting 140 mM HCO3-.

DOI： 10.1113/JP273306

Web of Science

Characterization of mutant CFTRs identified in Japanese Cystic Fibrosis patients

Nakao Kanako, Ishikura Reona, Nakakuki Miyuki, Yasui Masato, Ishiguro Hiroshi, Masaike Tomoko, Sohma Yoshiro

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 133 ( 3 ) page： S121-S121 2017.3

Evidence-based clinical practice guidelines for chronic pancreatitis 2015 Reviewed

Ito T, Ishiguro H, Ohara H, Kamisawa T, Sakagami J, Sata N, Takeyama Y, Hirota M, Miyakawa H, Igarashi H, Lee L, Fujiyama T, Hijioka M, Ueda K, Tachibana Y, Sogame Y, Yasuda H, Kato R, Kataoka K, Shiratori K, Sugiyama M, Okazaki K, Kawa S, Tando Y, Kinoshita Y, Watanabe M, Shimosegawa T

J Gastroenterol Vol. 51 ( 2 ) page： 85-92 2016.2

β3アドレナリン受容体およびβ2アドレナリン受容体遺伝子多型の運動時糖質代謝への寄与 Reviewed

近藤志保、藤木理代、山本明子、石黒　洋

総合保健体育科学 Vol. 39 page： 11-16 2016

名古屋大学における健診データ自動収集システムについて Reviewed

石黒　洋、中原久美子、宮田祐子、長尾杏子、千藤ますみ、市橋　淳、木村千春、小池晃彦、山本明子、岩間信太郎、押田芳治

CAMPUS HEALTH Vol. 53 ( 2 ) page： 33-36 2016

Functional characteristics of L1156F-CFTR associated with alcoholic chronic pancreatitis in Japanese. Reviewed

Kondo S, Fujiki K, Ko SB, Yamamoto A, Nakakuki M, Ito Y, Shcheynikov N, Kitagawa M, Naruse S, Ishiguro H.

Am J Physiol Gastrointest Liver Physiol Vol. 309 ( 4 ) page： G260-9 2015.8

ドルナーゼアルファとトブラマイシンの吸入療法が著効した嚢胞性線維症の幼児例 Reviewed

村上至孝、宮田豊寿、石黒　洋．

日本小児呼吸器学会雑誌 Vol. 26 ( 1 ) page： 28-34 2015.6

HCO3- secretion by SLC26A3 and mucosal defence in the colon. Invited Reviewed

Ishiguro H.

Acta Physiol (Oxf). Vol. 211 ( 1 ) page： 17-9 2014.5

嚢胞性線維症の2幼児例 Reviewed

柳元孝介、西　順一郎、田中主美、山元公恵、丸山慎介、石黒　洋、河野嘉文．

日本小児呼吸器学会雑誌 Vol. 24 ( 2 ) page： 132-137 2014.1

Inflammation increases cells expressing ZSCAN4 and progenitor-cell markers in the adult pancreas. Reviewed

Ko SB, Azuma S, Yokoyama Y, Yamamoto A, Kyokane K, Niida S, Ishiguro H, Ko MS.

Am J Physiol Gastrointest Liver Physiol Vol. 304 ( 12 ) page： G1103-16. 2013.6

アンケート調査による感染症の推定抗体保有率. Reviewed

山本明子、押田芳治、石黒　洋、小池晃彦、尾崎信暁、小川豊昭、津田　均、古橋忠晃

CAMPUS HEALTH Vol. 50 page： 173-178 2013

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Papers - ISHIGURO, Hiroshi