Faculty Profiles - ISHIGURO, Hiroshi

Papers - ISHIGURO, Hiroshi

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Volume-regulated anion channels conduct ATP in undifferentiated mammary cells and promote tumorigenesis in xenograft nude mouse Reviewed

Furuya, K; Hirata, H; Kobayashi, T; Ishiguro, H; Sokabe, M

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY Vol. 12 2025.1

Enhanced CFTR modulator efficacy in ΔF508 CFTR mouse organoids by ablation of RFFL ubiquitin ligase Reviewed

Hinata, D; Fukuda, R; Ishiguro, H; Kamada, Y; Okiyoneda, T

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 733 2024.11

Relationship between pancreatic exocrine status and survival in patients with cystic fibrosis in Japan

Kondo, S; Fujiki, K; Nakakuki, M; Kozawa, Y; Yamamoto, A; Takeyama, Y; Naruse, S; Ishiguro, H

ANNALS OF NUTRITION AND METABOLISM Vol. 79 page： 695 - 695 2023.8

Clinical and genetic features of cystic fibrosis in Japan Reviewed

Kozawa Yuka, Yamamoto Akiko, Nakakuki Miyuki, Fujiki Kotoyo, Kondo Shiho, Okada Takuto, Fukuyasu Tomoya, Yamaguchi Makoto, Taniguchi Itsuka, Nomura Nao, Liu Libin, Higuchi Mayuko, Niwa Erina, Sohma Yoshiro, Naruse Satoru, Takeyama Yoshifumi, Ishiguro Hiroshi

JOURNAL OF HUMAN GENETICS 2023.5

Bicarbonate transport of airway surface epithelia in luminally perfused mice bronchioles Reviewed

Liu Libin, Yamamoto Akiko, Yamaguchi Makoto, Taniguchi Itsuka, Nomura Nao, Nakakuki Miyuki, Kozawa Yuka, Fukuyasu Tomoya, Higuchi Mayuko, Niwa Erina, Tamada Tsutomu, Ishiguro Hiroshi

Vol. 72 ( 1 ) page： 1 - 16 2022.2

Japanese Siblings of Cystic Fibrosis With a Novel Large Heterozygous Deletion in the CFTR Gene Reviewed

Kawase Mayumi, Ogawa Masato, Hoshina Takayuki, Kojiro Masumi, Nakakuki Miyuki, Naruse Satoru, Ishiguro Hiroshi, Kusuhara Koichi

FRONTIERS IN PEDIATRICS Vol. 9 page： 1 - 7 2022.1

TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets

Araki, K; Araki, A; Honda, D; Izumoto, T; Hashizume, A; Hijikata, V; Yamada, S; Iguchi, Y; Hara, A; Ikumi, K; Kawai, K; Ishigaki, S; Nakamichi, Y; Tsunekawa, S; Seino, Y; Yamamoto, A; Takayama, Y; Hidaka, S; Tominaga, M; Ohara-Imaizumi, M; Suzuki, A; Ishiguro, H; Enomoto, A; Yoshida, M; Arima, H; Muramatsu, SI; Sobue, G; Katsuno, M

JOURNAL OF CLINICAL INVESTIGATION Vol. 129 ( 9 ) page： 3578 - 3593 2019.9

Screening for Regulatory Variants in 460 kb Encompassing the CFTR Locus in Cystic Fibrosis Patients

Kerschner Jenny L., Ghosh Sujana, Paranjapye Alekh, Cosme Wilmel R., Audrezet Marie-Pierre, Nakakuki Miyuki, Ishiguro Hiroshi, Ferec Claude, Rommens Johanna, Harris Ann

JOURNAL OF MOLECULAR DIAGNOSTICS Vol. 21 ( 1 ) page： 70 - 80 2019.1

SURESELECT SEQUENCING OF 460KB ENCOMPASSING THE CFTR LOCUS TO DETERMINE REGULATORY ELEMENT VARIANTS

Kerschner J. L., Ghosh S., Strug L. J., Ferec C., Nakakuki M., Ishiguro H., Rommens J., Harris A.

PEDIATRIC PULMONOLOGY Vol. 52 page： S265 - S265 2017.9

「特集」膵外分泌機能不全を再考する　〔巻頭言〕膵外分泌機能不全診療の現状と課題 Invited

石黒　洋

肝胆膵 Vol. 90 ( 2 ) page： 153 - 155 2025.2

「特集」膵外分泌機能不全を究める　小児における膵外分泌機能不全の診断と治療～嚢胞性線維症（cystic fibrosis）～ Invited

石黒　洋、藤木理代、近藤志保、中莖みゆき、小澤祐加、谷口いつか、山口　誠、野村奈央、丹羽永理奈、佐藤鈴菜、成瀬　達、山本明子

胆と膵 Vol. 46 ( 1 ) page： 91 - 97 2025.1

日本における嚢胞性線維症 Invited Reviewed

石黒　洋、小澤祐加、福井佐和、中莖みゆき、山口　誠、谷口いつか、野村奈央、古橋（樋口）万佑子、丹羽永理奈、佐藤鈴菜、山本明子

総合保健体育科学 Vol. 47 ( 1 ) page： 1 - 9 2024.7

Predictability of the national psychological stress screening for subsequent long-term psychiatric sick leave among employees: A multicenter nested case-control study. Reviewed

Kawamura T, Kobayashi D; University Network Analyses of Stress Check for Employees (UNASCE) investigators.

J Occup Environ Med Vol. 66 ( 5 ) page： 433 - 438 2024.5

「特集」希少肺疾患はどこまで解明されたか？　嚢胞性線維症 Invited

石黒　洋、藤木理代、中莖みゆき、小澤祐加、近藤志保、山口　誠、谷口いつか、野村奈央、古橋（樋口）万佑子、丹羽永理奈、佐藤鈴菜、相馬義郎、成瀬　達、山本明子

呼吸器内科 Vol. 45 ( 4 ) page： 391 - 397 2024.4

名古屋大学生協におけるハラルメニュー提供の現状と給食における多様性対応への一考察 Reviewed

持丸由香、山本明子、石黒　洋

総合保健体育科学 Vol. 46 ( 1 ) page： 60 - 67 2023

膵導管細胞の病態生理と嚢胞性線維症 Invited Reviewed

石黒　洋、山口　誠、山本明子

胆と膵 Vol. 43 ( 8 ) page： 743 - 750 2022.8

Focal biliary cirrhosisと門脈圧亢進症をともなう嚢胞性線維症の1例 Reviewed

山本明子、伊藤孝一、成瀬　達、服部日出夫、中莖みゆき、藤木理代、石黒　洋

日本消化器病学会雑誌 Vol. 118 ( 7 ) page： 686 - 697 2021.7

Regulation of Pancreatic Fluid and Electrolyte Secretion Invited Reviewed

Ishiguro H, Yamaguchi M, Yamamoto A

Pacreapedia: Exocrine Pancreas Knowledge Base page： 1 - 13 2021.3

大学生の肝機能とBMI Reviewed

山本明子、石黒　洋

Vol. 57 ( 2 ) page： 30 - 36 2020.6

大学生の定期健康診断における尿検査の意義と課題 Reviewed

小澤祐加、石黒　洋、守山敏樹、鈴木芳樹

Vol. 57 ( 2 ) page： 23 - 29 2020.6

健康白書の意義 Reviewed

石黒　洋

Vol. 57 ( 2 ) page： 2 - 4 2020.6

CLINICAL ASSESSMENT ON THE SEVERITY OF THE LUNG DISEASE IN YOUNG INDIVIDUALS WITH CYSTIC FIBROSIS IN JAPAN

Yoshimura Kunihiko, Kasagi Satoshi, Ishiguro Hiroshi, Naruse Satoru

RESPIROLOGY Vol. 24 page： 76 - 76 2019.11

Characterization of (G970-T1122)-CFTR, the most frequent CFTR mutant identified in Japanese cystic fibrosis patients

Wakabayashi-Nakao Kanako, Yu Yingchun, Nakakuki Miyuki, Hwang Tzyh-Chang, Ishiguro Hiroshi, Sohma Yoshiro

JOURNAL OF PHYSIOLOGICAL SCIENCES Vol. 69 ( 1 ) page： 103-112 2019.1

Incidence of Cystic Fibrosis in Japanese

Naruse S., Ishiguro H., Yamamoto A., Nakakuki M., Ozawa Y., Taniguchi I., Kondo S., Fujiki K., Futakuchi S., Takeyama Y.

PANCREAS Vol. 48 ( 10 ) page： 1497 - 1497 2019

Genetics and Pancreatic Exocrine Status of Cystic Fibrosis Patients in Japan

Kondo S., Fujiki K., Nakakuki M., Yamamoto A., Kozawa Y., Takeyama Y., Naruse S., Ishiguro H.

PANCREAS Vol. 48 ( 10 ) page： 1465 - 1466 2019

Comparison of Pancreatic Exocrine Status Between Patients With Cystic Fibrosis in Pediatric and Adult Age in Japan

Fujiki K., Kondo S., Nakakuki M., Kozawa Y., Yamamoto A., Takeyama Y., Naruse S., Ishiguro H.

PANCREAS Vol. 48 ( 10 ) page： 1427 - 1427 2019

Clinical Characteristics, Prognosis, and CFTR Mutations of Cystic Fibrosis in Japan

Ishiguro H., Yamamoto A., Fujiki K., Nakakuki M., Taniguchi I., Kozawa Y., Sohma Y., Naruse S., Takeyama Y.

PANCREAS Vol. 47 ( 10 ) page： 1395-1395 2018

Ethnicity impacts the cystic fibrosis diagnosis: A note of caution Reviewed

Bosch B, Bilton D, Sosnay P, Raraigh KS, Mak DY, Ishiguro H, Gulmans V, Thomas M, Cuppens H, Amaral M, De Boeck K

J Cyst Fibros Vol. 16 ( 4 ) page： 488 - 491 2017.7

Caffeine inhibits fluid secretion by interlobular ducts from guinea pig pancreas Reviewed

Mochimaru Y, Yamamoto A, Nakakuki M, Yamaguchi M, Taniguchi I, Ishiguro H

Pancreas Vol. 46 ( 4 ) page： 549-556 2017.4

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium Reviewed

Makoto Yamaguchi, Martin C. Steward, Kieran Smallbone, Yoshiro Sohma, Akiko Yamamoto, Shigeru B. H. Ko, Takaharu Kondo, Hiroshi Ishiguro

JOURNAL OF PHYSIOLOGY-LONDON Vol. 595 ( 6 ) page： 1947 - 1972 2017.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：WILEY

A computational model of guinea-pig pancreatic duct epithelium was developed to determine the transportmechanism by whichHCO(3)(-)ions are secretedat concentrations inexcess of 140mM. Parameters defining the contributions of the individual ion channels and transporters were estimated by least-squares fitting of the model predictions to experimental data obtained from isolated ducts and intact pancreas under a range of experimental conditions. The effects of cAMP-stimulated secretion were well replicated by increasing the activities of the basolateral Na+-HCO(3)(-)cotransporter (NBC1) and apical Cl-/HCO(3)(-)exchanger (solute carrier family 26 member A6; SLC26A6), increasing the basolateral K+ permeability and apical Cl(-)and HCO(3)(-)permeabilities (CFTR), and reducing the activity of the basolateral Cl-/HCO(3)(-)exchanger (anion exchanger 2; AE2). Under these conditions, the model secreted similar to 140 mM HCO(3)(-)at a rate of similar to 3 nl min(-1) mm(-2), which is consistent with experimental observations. Alternative 1: 2 and 1: 1 stoichiometries for Cl-/HCO(3)(-)exchange via SLC26A6 at the apical membrane were able to support a HCO3--rich secretion. Raising the HCO3-/Cl(-)permeability ratio of CFTR from 0.4 to 1.0 had little impact upon either the secreted HCO(3)(-)concentration or the volume flow. However, modelling showed that a reduction in basolateral AE2 activity by similar to 80% was essential in minimizing the intracellular Cl(-)concentration following cAMP stimulation and thereby maximizing the secreted HCO(3)(-)concentration. The addition of a basolateral Na+-K+-2Cl(-)cotransporter (NKCC1), assumed to be present in rat and mouse ducts, raised intracellular Cl- and resulted in a lower secreted HCO3- concentration, as is characteristic of those species. We conclude therefore that minimizing the driving force for Cl- secretion is the main requirement for secreting 140 mM HCO3-.

DOI： 10.1113/JP273306

Web of Science

Characterization of mutant CFTRs identified in Japanese Cystic Fibrosis patients

Nakao Kanako, Ishikura Reona, Nakakuki Miyuki, Yasui Masato, Ishiguro Hiroshi, Masaike Tomoko, Sohma Yoshiro

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 133 ( 3 ) page： S121-S121 2017.3

Evidence-based clinical practice guidelines for chronic pancreatitis 2015 Reviewed

Ito T, Ishiguro H, Ohara H, Kamisawa T, Sakagami J, Sata N, Takeyama Y, Hirota M, Miyakawa H, Igarashi H, Lee L, Fujiyama T, Hijioka M, Ueda K, Tachibana Y, Sogame Y, Yasuda H, Kato R, Kataoka K, Shiratori K, Sugiyama M, Okazaki K, Kawa S, Tando Y, Kinoshita Y, Watanabe M, Shimosegawa T

J Gastroenterol Vol. 51 ( 2 ) page： 85-92 2016.2

β3アドレナリン受容体およびβ2アドレナリン受容体遺伝子多型の運動時糖質代謝への寄与 Reviewed

近藤志保、藤木理代、山本明子、石黒　洋

総合保健体育科学 Vol. 39 page： 11-16 2016

名古屋大学における健診データ自動収集システムについて Reviewed

石黒　洋、中原久美子、宮田祐子、長尾杏子、千藤ますみ、市橋　淳、木村千春、小池晃彦、山本明子、岩間信太郎、押田芳治

CAMPUS HEALTH Vol. 53 ( 2 ) page： 33-36 2016

Functional characteristics of L1156F-CFTR associated with alcoholic chronic pancreatitis in Japanese. Reviewed

Kondo S, Fujiki K, Ko SB, Yamamoto A, Nakakuki M, Ito Y, Shcheynikov N, Kitagawa M, Naruse S, Ishiguro H.

Am J Physiol Gastrointest Liver Physiol Vol. 309 ( 4 ) page： G260-9 2015.8

ドルナーゼアルファとトブラマイシンの吸入療法が著効した嚢胞性線維症の幼児例 Reviewed

村上至孝、宮田豊寿、石黒　洋．

日本小児呼吸器学会雑誌 Vol. 26 ( 1 ) page： 28-34 2015.6

HCO3- secretion by SLC26A3 and mucosal defence in the colon. Invited Reviewed

Ishiguro H.

Acta Physiol (Oxf). Vol. 211 ( 1 ) page： 17-9 2014.5

嚢胞性線維症の2幼児例 Reviewed

柳元孝介、西　順一郎、田中主美、山元公恵、丸山慎介、石黒　洋、河野嘉文．

日本小児呼吸器学会雑誌 Vol. 24 ( 2 ) page： 132-137 2014.1

Inflammation increases cells expressing ZSCAN4 and progenitor-cell markers in the adult pancreas. Reviewed

Ko SB, Azuma S, Yokoyama Y, Yamamoto A, Kyokane K, Niida S, Ishiguro H, Ko MS.

Am J Physiol Gastrointest Liver Physiol Vol. 304 ( 12 ) page： G1103-16. 2013.6

アンケート調査による感染症の推定抗体保有率. Reviewed

山本明子、押田芳治、石黒　洋、小池晃彦、尾崎信暁、小川豊昭、津田　均、古橋忠晃

CAMPUS HEALTH Vol. 50 page： 173-178 2013

Molecular mechanisms of pancreatic stone formation in chronic pancreatitis. Reviewed

Ko SB, Azuma S, Yoshikawa T, Yamamoto A, Kyokane K, Ko MS, Ishiguro H.

Front Physiol Vol. 3 ( 415 ) 2012.11

Structure and function of the pancreas in the polycystic kidney rat. Reviewed

Yi L, Naruse S, Furuya S, Yamamoto A, Nakakuki M, Nagao S, Yoshihara D, Ko SB, Wei M, Kondo T, Ishiguro H.

Pancreas Vol. 41 ( 8 ) page： 1292-8 2012.11

Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO3- exchange in mouse pancreatic duct. Reviewed

Song Y, Yamamoto A, Steward MC, Ko SB, Stewart AK, Soleimani M, Liu BC, Kondo T, Jin CX, Ishiguro H.

Am J Physiol Cell Physiol Vol. 303 ( 8 ) page： C815-24 2012.8

CFTR polymorphisms of healthy individuals in two Chinese cities--Changchun and Nanjing. Reviewed

Jin CX, Fujiki K, Song Y, Ping Z, Nakakuki M, Wei MX, Zhang SM, Ishiguro H, Naruse S.

Nagoya J Med Sci Vol. 74 ( 3-4 ) page： 293-301 2012.8

Detection of a large heterozygous deletion and a splicing defect in the CFTR transcripts from nasal swab of a Japanese case of cystic fibrosis. Reviewed

Nakakuki M, Fujiki K, Yamamoto A, Ko SB, Yi L, Ishiguro M, Yamaguchi M, Kondo S, Maruyama S, Yanagimoto K, Naruse S, Ishiguro H.

J Hum Genet Vol. 57 ( 7 ) page： 427-33 2012.5

Physiology and pathophysiology of bicarbonate secretion by pancreatic duct epithelium. Invited Reviewed

Ishiguro H, Yamamoto A, Nakakuki M, Yi L, Ishiguro M, Yamaguchi M, Kondo S, Mochimaru Y.

Nagoya J Med Sci Vol. 74 ( 1-2 ) page： 1-18 2012.2

Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells.

Ko SB, Yamamoto A, Azuma S, Song H, Kamimura K, Nakakuki M, Gray MA, Becq F, Ishiguro H, Goto H.

Biochem Biophys Res Commun Vol. 410 page： 904-909 2011

SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization.

Stewart AK, Shmukler BE, Vandorpe DH, Reimold F, Heneghan JF, Nakakuki M, Akhavein A, Ko SB, Ishiguro H, Alper SL.

Am J Physiol Cell Physiol Vol. 301 page： C289-C303 2011

Intravenous fluid therapy successfully prevents renal injury by gemcitabine in patients with pancreatic cancer.

Ko SB, Azuma S, Anzai N, Yamamoto Y, Mizuno N, Kamimura K, Ishiguro H, Goto H.

Pancreas Vol. 40 page： 784-786 2011

Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis Reviewed

Ko SB, Mizuno N, Yatabe Y, Yoshikawa T, Ishiguro H, Yamamoto A, Azuma S, Naruse S, Yamao K, Muallem S, Goto H.

Gastroenterology Vol. 138 ( 5 ) page： 1988-96 2010.5

水素ガス吸入における皮膚ガス水素の動態

野瀬和利、下内章人、山口　誠、石黒　洋、近藤孝晴

安定同位体と生体ガス・医学応用 Vol. 2 page： 35-39 2010

High glucose inhibits HCO3- and fluid secretion in rat pancreatic ducts Reviewed

Futakuchi S, Ishiguro H, Naruse S, Ko SB, Fujiki K, Yamamoto A, Nakakuki M, Song Y, Steward MC, Kondo T, Goto H

Pflügers Arch Vol. 459 ( 1 ) page： 215-226 2009.11

*Molecular and cellular regulation of pancreatic duct cell function Invited Reviewed

Steward MC, Ishiguro H

Curr Opin Gastroenterol Vol. 25 ( 5 ) page： 447-453 2009.9

Functional coupling of apical Cl-/HCO3- exchange with CFTR in stimulated HCO3- secretion by guinea pig interlobular pancreatic duct Reviewed

Stewart AK, Yamamoto A, Nakakuki M, Kondo T, Alper SL, Ishiguro H

Am J Physiol Gastrointest Liver Physiol Vol. 296 ( 6 ) page： G1307-1317 2009.6

*CFTR functions as a bicarbonate channel in pancreatic duct cells Reviewed

Ishiguro H, Steward MC, Naruse S, Ko SB, Goto H, Case RM, Kondo T, Yamamoto A

J Gen Physiol Vol. 133 ( 3 ) page： 315-326 2009.3

Breath hydrogen produced by ingestion of commercial hydrogen water and milk.

Shimouchi A, Nose K, Yamaguchi M, Ishiguro H, Kondo T.

Biomark Insights Vol. 4 page： 27-32 2009

モルモット消化管におけるCCK受容体の分布

藤木理代、石黒　洋、成瀬　達

名古屋学芸大学健康・栄養研究所年報 Vol. 3 page： 11-16 2009

Measurement of chloride concentrations of insensible sweat collected from thumb Reviewed

Vol. 23 ( 4 ) page： 486-493 2008.8

*Cystic fibrosis transmembrane conductance regulator and SLC26 transporters in HCO3(-) secretion by pancreatic duct cells Invited Reviewed

Ishiguro H, Steward M, Naruse S

Sheng Li Xue Bao (Chinese Journal of Physiology) Vol. 59 ( 4 ) page： 465-476 2007.8

Allochronic biliary strictures appeared in the different regions of the bile duct tree in a patient with autoimmune pancreatitis Reviewed

Ko SB, Naruse S, Ishiguro H, Yoshikawa T, Yamamoto T, Futakuchi S, Goto H

Pancreas Vol. 34 ( 4 ) page： 479-481 2007.5

Acute tubulointerstitial nephritis associated with long-term gemcitabine therapy Reviewed

Yamamoto A, Naruse S, Ito M, Ishiguro H, Ko SB, Yoshikawa T, Kondo T, Goto H

Pancreas Vol. 34 ( 4 ) page： 378-379 2007.4

*Effect of Slc26a6 deletion on apical Cl-/HCO3--exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic duct Reviewed

Ishiguro H, Namkung W, Yamamoto A, Wang Z, Worrell RT, Xu J, Lee MG, Soleimani M

Am J Physiol Gastrointest Liver Physiol Vol. 292 ( 1 ) page： G447-G455 2007.1

Identification of key residues that cause differential gallbladder response to PACAP and VIP in the guinea pig.

Wei M, Fujiki K, Ando E, Zhang S, Ozaki T, Ishiguro H, Kondo T, Nokihara K, Wray V, Naruse S.

Am J Physiol Gastrointest Liver Physiol Vol. 292 page： G76-G83 2007

糖尿病患者の呼気中CO濃度

近藤孝晴、山根則夫、石黒　洋、山本明子、下内章人、野瀬和利

呼気生化学の進歩 Vol. 9 page： 15-18 2007

Relationship between skin acetone and blood beta-hydroxybutyrate concentrations in diabetes Reviewed

Yamane N, Tsuda T, Nose K, Yamamoto A, Ishiguro H, Kondo T

Clin Chim Acta Vol. 365 ( 1-2 ) page： 325-329 2006.10

Sweat chloride measurement with a highly sensitive electrode.

Naruse S, Ishiguro H, Shirota K, Nakakuki M, Yamamoto A, Kondo T.

Pancreas Vol. 33 page： 100 2006

Fecal pancreatic elastase: a reproducible marker for severe exocrine pancreatic insufficiency.

Naruse S, Ishiguro H, Ko SB, Yoshikawa T, Yamamoto T, Yamamoto A, Futakuchi S, Goto H, Saito Y, Takahashi S.

J Gastroenterol Vol. 41 page： 901-908 2006

*Mechanisms of bicarbonate secretion in the pancreatic duct Invited Reviewed

Steward MC, Ishiguro H, Case RM

Annu Rev Physiol Vol. 67 page： 377-409 2005.1

Dual effects of n-alcohols on fluid secretion from guinea pig pancreatic ducts

Hamada H, Ishiguro H, Yamamoto A, Shimano-Futakuchi S, Ko SB, Yoshikawa T, Goto H, Kitagawa M, Hayakawa T, Seo Y, Naruse S.

Am J Physiol Cell Physiol Vol. 288 page： C1431-1439 2005

糖尿病患者における呼気アセトン測定の意義

近藤孝晴、山根則夫、石黒　洋、野瀬和利、津田孝雄、植田秀雄

総合保健体育科学 Vol. 28 page： 57-60 2005

A finger sweat chloride test for the detection of the high-risk group of chronic pancreatitis.

Naruse S, Ishiguro H, Suzuki Y, Fujiki K, Ko SBH, Mizuno N, Takemura T, Yamamoto A, Yoshikawa T, Jin C, Suzuki R, Kitagawa M, Tsuda T, Kondo T, Hayakawa T.

Pancreas Vol. 28 page： e80-e85 2004

Genetic evidence for CFTR dysfunction in Japanese: background for chronic pancreatitis.

Fujiki K, Ishiguro H, Ko SBH, Mizuno N, Suzuki Y, Takemura T, Yamamoto A, Yoshikawa T, Kitagawa M, Hayakawa T, Sakai Y, Takayama T, Saito M, Kondo T, Naruse S.

J Med Genet Vol. 41 page： e55 2004

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Papers - ISHIGURO, Hiroshi