Updated on 2021/11/04

写真a

 
MIZUNO, Masashi
 
Organization
Graduate School of Medicine Department of Renal Replacement Therapy Endowed Chair Designated professor
Title
Designated professor
Contact information
メールアドレス

Degree 1

  1. Doctor of Medicine ( Nagoya University ) 

Research Interests 5

  1. complement

  2. complement regulator

  3. marine envenomation

  4. nephritis

  5. peritoneal dialysis

Research Areas 2

  1. Others / Others  / Kidney Internal Medicine

  2. Others / Others  / 腎臓内科学

Current Research Project and SDGs 1

  1. Research for roles of complement system in inflammatory diseases.

Research History 12

  1. Renal Replacement Therapy   Professor

    2017.7

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    Country:Japan

  2. Associate Professor

    2013.2 - 2017.6

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    Country:Japan

  3. Assistant professor

    2010.2 - 2013.1

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    Country:Japan

  4. 寄附講座助教

    2009.9 - 2010.1

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    Country:Japan

  5. Assistant professor

    2006.5 - 2007.4

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    Country:Japan

  6. Postdoctoral research fellow

    2004.1 - 2006.5

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    Country:Japan

  7. Visiting scholar

    2001.10 - 2003.12

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    Country:Japan

  8. 学内研究生

    2001.8 - 2001.10

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    Country:Japan

  9. Associate professor

    1998.6 - 2001.7

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    Country:Japan

  10. Medical Doctor

    1994.4 - 1998.5

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    Country:Japan

  11. Internal Medicine

    1991.4 - 1994.3

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    Country:Japan

  12. 研修医(全般・内科)

    1989.6 - 1991.3

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    Country:Japan

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Education 1

  1. Hirosaki University   Faculty of Medicine

    - 1989

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    Country: Japan

Professional Memberships 7

  1. 日本内科学会

  2. 日本透析医会   評議員

    2020.6

  3. 日本腎臓病学会   学術評議員

  4. International complement society

  5. 日本腹膜透析学医会   評議員

    2019.11

  6. The Japanese Association for Comeplement Research

  7. International Society for Peritoneal Dialysis

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Committee Memberships 4

  1. The 9th Asia Pacific Chapter Meeting of International Society for Peritoneal Dialysis.   Co chair, Secretariat  

    2019.9   

  2. 日本補体学会   理事  

    2016   

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    Committee type:Academic society

  3. 補体研究会運営委員会   運営委員  

    2009.8 - 2013.8   

  4. 日本補体学会   学会誌「補体」編集委員長  

       

 

Papers 240

  1. Vasculopathy plays an important role during the development and relapse of encapsulating peritoneal sclerosis with conventional peritoneal dialysis solutions. Reviewed

    Tawada M, Ito Y, Banshodani M, Yamashita M, Shintaku S, Sun T, Suzuki Y, Kinashi H, Kubo Y, Ando M, Yamaguchi M, Katsuno T, Mizuno M, Kawanishi H

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   Vol. 36 ( 8 ) page: 1519 - 1526   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ndt/gfaa073

    PubMed

  2. C1 inhibitor mitigates peritoneal injury in zymosan-induced peritonitis

    Ozeki Toshikazu, Mizuno Masashi, Iguchi Daiki, Kojima Hiroshi, Kim Hangsoo, Suzuki Yasuhiro, Kinashi Hiroshi, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   Vol. 320 ( 6 ) page: F1123 - F1132   2021.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajprenal.00600.2020

    Web of Science

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  3. Demographic, clinical characteristics and treatment outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulonephritis in Japan: A retrospective analysis of data from the Japan Renal Biopsy Registry.

    Nakagawa N, Mizuno M, Kato S, Maruyama S, Sato H, Nakaya I, Sugiyama H, Fujimoto S, Miura K, Matsumura C, Gotoh Y, Suzuki H, Kuroki A, Yoshino A, Nakatani S, Hiromura K, Yamamoto R, Yokoyama H, Narita I, Isaka Y

    PloS one   Vol. 16 ( 9 ) page: e0257397   2021

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0257397

    PubMed

  4. Complement regulation and kidney diseases: recent knowledge of the double-edged roles of complement activation in nephrology Invited Reviewed

    Mizuno Masashi, Suzuki Yasuhiro, Ito Yasuhiko

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 22 ( 1 ) page: 3-14   2018.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-017-1405-x

    Web of Science

    PubMed

  5. High Levels of Soluble C5b-9 Complex in Dialysis Fluid May Predict Poor Prognosis in Peritonitis in Peritoneal Dialysis Patients Reviewed International coauthorship

    Mizuno Masashi, Suzuki Yasuhiro, Higashide Keiko, Sei Yumi, Iguchi Daiki, Sakata Fumiko, Horie Masanobu, Maruyama Shoichi, Matsuo Seiichi, Morgan B. Paul, Ito Yasuhiko

    PLOS ONE   Vol. 12 ( 1 ) page: e0169111   2017

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0169111

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  6. Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy. Reviewed

    Sei Y., Mizuno M., Suzuki Y., Imai M., Higashide K., Harris CL., Sakata F., Iguchi D., Fujiwara M., Kodera Y., Maruyama S., Matsuo S., Ito Y.

    Mol Immunol   Vol. 65   page: 302-309   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

  7. Anti-C5a complementary peptide ameliorates acute peritoneal injuries induced by neutralization of Crry and CD59. Reviewed

    Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y.

    Am J Physiol Renal Physiol   Vol. in press   page: xxx-xxx   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  8. Exploiting the Nephrotoxic Effects of Venom from the Sea Anemone, Phyllodiscus semoni, to Create a Hemolytic Uremic Syndrome Model in the Rat

    Mizuno Masashi, Ito Yasuhiko, Morgan B. Paul

    MARINE DRUGS   Vol. 10 ( 7 ) page: 1582 - 1604   2012.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/md10071582

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  9. Membrane complement regulators protect against fibrin exudation increases in a severe peritoneal inflammation model in rats.

    Mizuno M, Ito Y, Mizuno T, Harris CL, Suzuki Y, Okada N, Matsuo S, Morgan BP

    American journal of physiology. Renal physiology   Vol. 302 ( 10 ) page: F1245 - 51   2012.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajprenal.00652.2011

    PubMed

  10. Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation. Reviewed

    Mizuno T, Mizuno M, Morgan BP, Noda Y, Yamada K, Okada N, Yuzawa Y, Matsuo S, Ito Y

    Nephrol Dial Transplant   Vol. 26 ( 6 ) page: 1821-1830   2011.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  11. Zymosan, but not lipopolysaccharide, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model. Reviewed

    Mizuno M, Ito Y, Hepburn N, Mizuno T, Noda Y, Yuzawa Y, Harris CL, Morgan BP, Matsuo S.

    J Immunol   Vol. 183   page: 1403-1412   2009

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  12. High levels of complement C3a receptor in the glomeruli in lupus nephritis. Reviewed International coauthorship International journal

    Mizuno M, Blanchin S, Gasque P, Nishikawa K, Matsuo S

    American journal of kidney diseases : the official journal of the National Kidney Foundation   Vol. 49 ( 5 ) page: 598 - 606   2007.5

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.ajkd.2007.02.271

    PubMed

  13. Nucleic acids and CD46 are key regulators in innate immune recognition and the finely tuned removal of “danger-self". Reviewed

    Elward K, Griffiths M., Mizuno M., Harris CL., Neal JW., Morgan BP., Gasque P.

    J Biol Chem   Vol. 280   page: 36342-36354   2005

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    Language:English   Publishing type:Research paper (scientific journal)  

  14. Generation of a recombinant, membrane-targeted form of the complement regulator, CD59: activity in vitro and in vivo. Reviewed

    Fraser DA., Harris CL., Williams AS., Mizuno M., Gallagher S., Smith RAG., Morgan BP.

    J. Biol. Chem.   Vol. 278   page: 48921-48927   2003

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    Language:English   Publishing type:Research paper (scientific journal)  

  15. Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones. Reviewed International journal

    Nagano F, Mizuno T, Imai M, Takahashi K, Tsuboi N, Maruyama S, Mizuno M

    FEBS open bio     2021.10

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/2211-5463.13322

    PubMed

  16. Low-GDP, pH-neutral solutions preserve peritoneal endothelial glycocalyx during long-term peritoneal dialysis. Reviewed International coauthorship

    Sugiyama N, Tawada M, Sun T, Suzuki Y, Kinashi H, Yamaguchi M, Katsuno T, Aten J, Vlahu CA, van Kuppevelt TH, Takei Y, Ishimoto T, Maruyama S, Mizuno M, Ito Y

    Clinical and experimental nephrology   Vol. 25 ( 9 ) page: 1035 - 1046   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-021-02078-9

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  17. A case of temporary metastatic pulmonary calcification in a patient with hyperparathyroidism on peritoneal dialysis International coauthorship International journal

    Kawase Kota, Takagi Kimiaki, Mizuno Masashi, Horie Masanobu

    CLINICAL NEPHROLOGY   Vol. 95 ( 3 ) page: 161 - 165   2021.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.5414/CN110337

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    PubMed

  18. Refractory Hypotension Caused by Selenium Deficiency in a Patient on Peritoneal Dialysis Reviewed

    Ryuge Akihiro, Kim Hangsoo, Suzuki Yasuhiro, Okazaki Masaki, Kojima Hiroshi, Saito Shoji, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Mizuno Masashi

    INTERNAL MEDICINE   Vol. 60 ( 15 ) page: 2461 - 2464   2021

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:一般社団法人 日本内科学会  

    <p>Selenium is essential for human health; its deficiency leads to cardiac dysfunction. We herein report a 79-year-old man on peritoneal dialysis who presented with refractory hypotension caused by selenium deficiency. He was admitted to our hospital with bacterial pneumonia and hypotension and abnormal electrocardiogram (ECG) findings. Despite improvement of pneumonia, his hypotension continued, and intravenous noradrenalin could not be discontinued. His serum selenium level was extremely low, and he was started on intravenous selenium. His hypotension and ECG findings gradually improved, and noradrenalin was discontinued. Physicians should consider selenium deficiency when patients on peritoneal dialysis show refractory hypotension. </p>

    DOI: 10.2169/internalmedicine.6632-20

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  19. Oral Antibiotics are Effective for Preventing Colonoscopy-associated Peritonitis as a Preemptive Therapy in Patients on Peritoneal Dialysis

    Suzuki Yasuhiro, Mizuno Masashi, Kojima Hiroshi, Sato Yuka, Kim Hangsoo, Kinashi Hiroshi, Katsuno Takayuki, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 60 ( 3 ) page: 353 - 356   2021

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:一般社団法人 日本内科学会  

    <p><b>Objective </b>In patients on peritoneal dialysis (PD), it was reported that colonoscopy, but not upper gastrointestinal endoscopy, could cause peritonitis as a complication. A guideline of the International Society for Peritoneal Dialysis recommends preemptive intravenous antibiotics administration of ampicillin and aminoglycoside with or without metronidazole, to prevent colonoscopy-associated peritonitis. In this study, we retrospectively evaluated the effects of preemptive antibiotics therapy by oral administration instead of intravenous administration. </p><p><b>Methods </b>We investigated the incidence of colonoscopy-associated peritonitis in a single center. In 170 patients undergoing PD between January 2010 and December 2019, 50 colonoscopies were performed, including 49 with oral administration of amoxicillin and ciprofloxacin and/or metronidazole as preemptive therapy 1 hour before the colonoscopy procedure, and 1 without. </p><p><b>Results </b>We observed no incidence of colonoscopy-associated peritonitis. </p><p><b>Conclusion </b>Generally, oral administration of preemptive antibiotics is less painful and more convenient than intravenous administration, especially in outpatient procedures, such as a colonoscopy. Our results suggest that oral antibiotic administration might be effective for preventing colonoscopy-associated peritonitis in PD patients. </p>

    DOI: 10.2169/internalmedicine.5092-20

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  20. Impact on survival of urgent dialysis initiation in patients with end-stage renal disease: a case-control study Reviewed

    Takagi Kimiaki, Mizuno Masashi, Kawase Kota, Minoshima Kenichi, Yamaha Masayoshi, Horie Masanobu

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 24 ( 12 ) page: 1154 - 1161   2020.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-020-01931-7

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  21. ANALYSIS OF FREQUENCY AND KINDS OF ALARM HISTORIES OF HOME PD SYSTEM KAGUYA DURING THE INTRODUCTION: PERIOD IN A SINGLE CENTRE

    Hiramatsu Tetsuaki, Mizuno Masasi, Suzuki Yasuhiro, Nomori Sumiyo, Suzuki Masafumi, Shiga Yoshiko, Sato Yuka, Nakamura Tomohiro, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Koyama Tomio

    NEPHROLOGY   Vol. 25   page: 77 - 78   2020.10

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  22. CASES OF ACUTE APPENDICITIS IN PATIENTS ON PERITONEAL DIALYSIS (PD) IN A SINGLE CENTRE DURING 15 YEARS

    Mizuno Masashi, Suzuki Yasuhiro, Kojima Hiroshi, Sato Yuka, Kinashi Hiroshi, Katsuno Takayuki, Maruyama Shoichi, Ito Yasuhiko

    NEPHROLOGY   Vol. 25   page: 82 - 82   2020.10

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  23. Dietary salt restriction during conservative therapy may prevent declines in residual renal function for the first year after starting peritoneal dialysis in patients with end-stage renal diseases. Reviewed

    Hiramatsu T, Mizuno M, Suzuki Y, Nomori S, Shiga Y, Sun T, Ishii T, Hiroshi Kojima H, Katsuno T, Nakamura T, Kosugi T, Maruyama S, Koyama T, Noguchi S, Ito Y

        2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.15761/IFNM.1000276.

  24. Eculizumab for pediatric dense deposit disease: A case report and literature review. Reviewed International journal

    Kasahara K, Gotoh Y, Majima H, Takeda A, Mizuno M

    Clinical nephrology. Case studies   Vol. 8   page: 96 - 102   2020

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    DOI: 10.5414/CNCS110309

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  25. Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia Reviewed International journal

    Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 59 ( 5 ) page: 683 - 687   2020

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.3775-19

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  26. The effectiveness and safety of computed tomographic peritoneography and video-assisted thoracic surgery for hydrothorax in peritoneal dialysis patients: A retrospective cohort study in Japan.

    Matsuoka N, Yamaguchi M, Asai A, Kamiya K, Kinashi H, Katsuno T, Kobayashi T, Tamai H, Morinaga T, Obayashi T, Nakabayashi K, Koide S, Nakanishi M, Koyama K, Suzuki Y, Ishimoto T, Mizuno M, Ito Y

    PloS one   Vol. 15 ( 9 ) page: e0238602   2020

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    DOI: 10.1371/journal.pone.0238602

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  27. Excessive salt intake increases peritoneal solute transport rate via local tonicity-responsive enhancer binding protein in subtotal nephrectomized mice Reviewed International coauthorship International journal

    Sun Ting, Sakata Fumiko, Ishii Takako, Tawada Mitsuhiro, Suzuki Yasuhiro, Kinashi Hiroshi, Katsuno Takayuki, Takei Yoshifumi, Maruyama Shoichi, Mizuno Masashi, Ito Yasuhiko

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 34 ( 12 ) page: 2031 - 2042   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ndt/gfz045

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  28. HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy. Reviewed International journal

    Kawakita C, Kinomura M, Otaka N, Kitagawa M, Sugiyama H, Kusano N, Mizuno M, Wada J

    Internal medicine (Tokyo, Japan)   Vol. 58 ( 20 ) page: 3001 - 3007   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:一般社団法人 日本内科学会  

    <p>A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated. </p>

    DOI: 10.2169/internalmedicine.2439-18

    PubMed

  29. CD55 EXPRESSION CHANGES IN MESOTHELIAL CELLS OF PATIENTS ON PERITONEAL DIALYSIS (PD) THERAPY Reviewed

    Ozeki Toshikazu, Mizuno Masashi, Kobayashi Kazuma, Iguchi Daiki, Sei Yumi, Suzuki Yasuhiro, Kojima Hiroshi, Fukui Sosuke, Yamashita Ryoko, Kinashi Hiroshi, Imai Masaki, Maruyama Shoichi, Ito Yasuhiko

    MOLECULAR IMMUNOLOGY   Vol. 114   page: 422-422   2019.10

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  30. Connective tissue growth factor is correlated with peritoneal lymphangiogenesis Reviewed International coauthorship International journal

    Kinashi Hiroshi, Toda Naohiro, Sun Ting, Nguyen Tri Q., Suzuki Yasuhiro, Katsuno Takayuki, Yokoi Hideki, Aten Jan, Mizuno Masashi, Maruyama Shoichi, Yanagita Motoko, Goldschmeding Roel, Ito Yasuhiko

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 12175   2019.8

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    DOI: 10.1038/s41598-019-48699-9

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  31. Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research. Reviewed International journal

    Ohno T, Miyasaka Y, Kuga M, Ushida K, Matsushima M, Kawabe T, Kikkawa Y, Mizuno M, Takahashi M

    Experimental animals   Vol. 68 ( 3 ) page: 243 - 255   2019.8

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    DOI: 10.1538/expanim.18-0185

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  32. Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients Reviewed International journal

    Tawada Mitsuhiro, Hamada Chieko, Suzuki Yasuhiro, Sakata Fumiko, Sun Ting, Kinashi Hiroshi, Katsuno Takayuki, Takei Yoshifumi, Maruyama Shoichi, Honda Kazuho, Mizuno Masashi, Ito Yasuhiko

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 23 ( 5 ) page: 689 - 699   2019.5

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    DOI: 10.1007/s10157-018-1679-7

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  33. Differences in peritoneal solute transport rates in peritoneal dialysis. Reviewed International coauthorship International journal

    Asano M, Ishii T, Hirayama A, Mizuno M, Suzuki Y, Sakata F, Akiyama SI, Maruyama S, Soga T, Kinashi H, Katsuno T, Ito Y

    Clinical and experimental nephrology   Vol. 23 ( 1 ) page: 122 - 134   2019.1

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    DOI: 10.1007/s10157-018-1611-1

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  34. Safety and effectiveness of eculizumab for pediatric patients with atypical hemolytic-uremic syndrome in Japan: interim analysis of post-marketing surveillance.

    Ito S, Hidaka Y, Inoue N, Kaname S, Kato H, Matsumoto M, Miyakawa Y, Mizuno M, Okada H, Shimono A, Matsuda T, Maruyama S, Fujimura Y, Nangaku M, Kagami S

    Clinical and experimental nephrology   Vol. 23 ( 1 ) page: 112 - 121   2019.1

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    DOI: 10.1007/s10157-018-1610-2

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  35. Safety and effectiveness of eculizumab for adult patients with atypical hemolytic-uremic syndrome in Japan: interim analysis of post-marketing surveillance.

    Kato H, Miyakawa Y, Hidaka Y, Inoue N, Ito S, Kagami S, Kaname S, Matsumoto M, Mizuno M, Matsuda T, Shimono A, Maruyama S, Fujimura Y, Nangaku M, Okada H

    Clinical and experimental nephrology   Vol. 23 ( 1 ) page: 65 - 75   2019.1

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    DOI: 10.1007/s10157-018-1609-8

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  36. Increase of Eosinophil in Dialysate During Induction of Peritoneal Dialysis Reviewed International journal

    Shigemoto Emi, Mizuno Masashi, Suzuki Yasuhiro, Kobayashi Kazuma, Sakata Fumiko, Kariya Tetsuyoshi, Katsuno Takayuki, Maruyama Shoichi, Ito Yasuhiko

    PERITONEAL DIALYSIS INTERNATIONAL   Vol. 39 ( 1 ) page: 90 - +   2019

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3747/pdi.2017.00205

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  37. Anti-C5a complementary peptide mitigates zymosan-induced severe peritonitis with fibrotic encapsulation in rat pretreated with methylglyoxal. Reviewed International coauthorship International journal

    Iguchi D, Mizuno M, Suzuki Y, Sakata F, Maruyama S, Okada A, Okada H, Ito Y

    American journal of physiology. Renal physiology   Vol. 315 ( 6 ) page: F1732 - F1746   2018.12

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajprenal.00172.2018

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  38. Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis. Reviewed International journal

    Katsuno T, Ozaki T, Ozeki T, Hachiya A, Kim H, Kato N, Ishimoto T, Kato S, Kosugi T, Tsuboi N, Mizuno M, Ito Y, Maruyama S

    Clinical and experimental nephrology   Vol. 22 ( 6 ) page: 1341 - 1350   2018.12

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    DOI: 10.1007/s10157-018-1590-2

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  39. Extracellular histones decrease the expression of membrane complement regulators

    Mizuno Tomohiro, Nagano Fumihiko, Mizuno Masashi, Iwata Ayumi, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

    MOLECULAR IMMUNOLOGY   Vol. 102   page: 189-189   2018.10

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    DOI: 10.1016/j.molimm.2018.06.158

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  40. Peritoneal expression of membrane complement regulators in peritoneal dialysis patients with fungal peritonitis

    Fukui Sosuke, Suzuki Yasuhiro, Tawada Mitsuhiro, Matsukawa Yoshihisa, Imai Masaki, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi

    MOLECULAR IMMUNOLOGY   Vol. 102   page: 152-152   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molimm.2018.06.072

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  41. SODIUM RESTRICTED DIET DURING CONSERVATIVE THERAPY IN PATIENTS WITH END-STAGE RENAL DISEASES (ESRD) MAY RESCUE RESIDUAL RENAL FUNCTION (RRF) FOR THE FIRST YEAR AFTER STARTING PERITONEAL DIALYSIS (PD)

    Hiramatsu Tetsuaki, Mizuno Masashi, Nomori Sumiyo, Sakata Fumiko, Suzuki Yasuhiro, Maruyama Shoichi, Yasuhiko Ito, Noguchi Satoshi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 33   page: .   2018.5

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  42. TGF-beta 1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis

    Kariya Tetsuyoshi, Nishimura Hayato, Mizuno Masashi, Suzuki Yasuhiro, Matsukawa Yoshihisa, Sakata Fumiko, Maruyama Shoichi, Takei Yoshifumi, Ito Yasuhiko

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   Vol. 314 ( 2 ) page: F167 - F180   2018.2

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    DOI: 10.1152/ajprenal.00052.2017

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  43. Current Status of Peritoneal Dialysis in Japan. Reviewed International coauthorship International journal

    Ito Y, Tawada M, Tine S, Mizuno M, Suzuki Y, Katsuno T

    Contributions to nephrology   Vol. 196   page: 123 - 128   2018

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    DOI: 10.1159/000485711

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  44. Peritoneal eosinophils increase during induction of peritoneal dialysis and may be related to production of C3a in peritoneal dialysate

    Mizuno Masashi, Shigemoto Emi, Kobayashi Kazuma, Iguchi Daiki, Sakata Fumiko, Suzuki Yasuhiro, Maruyama Shoichi, Ito Yasuhiko

    MOLECULAR IMMUNOLOGY   Vol. 89   page: 193-193   2017.9

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    DOI: 10.1016/j.molimm.2017.06.195

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  45. Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9 Reviewed International coauthorship International journal

    Taylor Ronald P., Lindorfer Margaret A., Cook Erika M., Beurskens Frank J., Schuurman Janine, Parren Paul W. H. I., Zent Clive S., VanDerMeid Karl R., Burack Richard, Mizuno Masashi, Morgan B. Paul

    CLINICAL IMMUNOLOGY   Vol. 181   page: 24 - 28   2017.8

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    DOI: 10.1016/j.clim.2017.05.016

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  46. Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice

    Yashima Akihito, Mizuno Masashi, Yuzawa Yukio, Shimada Koki, Suzuki Norihiko, Tawada Hideo, Sato Waichi, Tsuboi Naotake, Maruyama Shoichi, Ito Yasuhiko, Matsuo Seiichi, Ohno Tamio

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 21 ( 4 ) page: 589-596   2017.8

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    DOI: 10.1007/s10157-016-1339-8

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  47. Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice Reviewed International journal

    Tomita Takako, Arai Satoko, Kitada Kento, Mizuno Masashi, Suzuki Yasuhiro, Sakata Fumiko, Nakano Daisuke, Hiramoto Emiri, Takei Yoshifumi, Maruyama Shoichi, Nishiyama Akira, Matsuo Seiichi, Miyazaki Toru, Ito Yasuhiko

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 6450   2017.7

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    DOI: 10.1038/s41598-017-06824-6

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  48. Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice

    Sakata Fumiko, Ito Yasuhiko, Mizuno Masashi, Sawai Akiho, Suzuki Yasuhiro, Tomita Takako, Tawada Mitsuhiro, Tanaka Akio, Hirayama Akiyoshi, Sagara Akihiro, Wada Takashi, Maruyama Shoichi, Soga Tomoyoshi, Matsuo Seiichi, Imai Enyu, Takei Yoshifumi

    LABORATORY INVESTIGATION   Vol. 97 ( 4 ) page: 432 - 446   2017.4

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    DOI: 10.1038/labinvest.2017.4

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  49. Complement component 5 promotes lethal thrombosis Reviewed International coauthorship International journal

    Mizuno Tomohiro, Yoshioka Kengo, Mizuno Masashi, Shimizu Mie, Nagano Fumihiko, Okuda Tomoyuki, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

    SCIENTIFIC REPORTS   Vol. 7   page: 42714   2017.2

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    DOI: 10.1038/srep42714

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  50. PDのエビデンス

    多和田 光洋, 鈴木 康弘, 水野 正司, 伊藤 恭彦

    日本透析医学会雑誌   Vol. 50 ( 11 ) page: 685 - 691   2017

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    DOI: 10.4009/jsdt.50.685

  51. Recent analysis of status and outcomes of peritoneal dialysis in the Tokai area of Japan: the second report of the Tokai peritoneal dialysis registry.

    Mizuno M, Ito Y, Suzuki Y, Sakata F, Saka Y, Hiramatsu T, Tamai H, Mizutani M, Naruse T, Ohashi N, Kasuga H, Shimizu H, Kurata H, Kurata K, Suzuki S, Kido S, Tsuruta Y, Matsuoka T, Horie M, Maruyama S, Matsuo S

    Clinical and experimental nephrology   Vol. 20 ( 6 ) page: 960 - 971   2016.12

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    DOI: 10.1007/s10157-016-1249-9

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  52. Therapeutic effects of a C5a antagonist, AcPepA, for severe peritoneal injuries associated with fungal infection in a rat model

    Mizuno Masashi, Iguchi Daiki, Shigemoto Emi, Kobayashi Kazuma, Sakata Fumiko, Suzuki Yasuhiro, Okada Alan, Okada Hidechika, Matsuo Seiichi, Ito Yasuhiko

    IMMUNOBIOLOGY   Vol. 221 ( 10 ) page: 1212 - 1212   2016.10

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    DOI: 10.1016/j.imbio.2016.06.193

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  53. TGF-beta-VEGF-A PATHWAY INDUCES NEOANGIOGENESIS IN PERITONEAL FIBROSIS OF PERITONEAL DIALYSIS

    Kariya Tetsuyoshi, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Sakata Fumiko, Terabayashi Takeshi, Ishii Takako, Tawada Mitsuhiro, Iguchi Daiki, Maruyama Shoichi, Matsuo Seiichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 31   page: 35 - 35   2016.5

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  54. Depression of complement regulatory factors in rat and human renal grafts is associated with the pregress of acute T-cell medicated rejection. Reviewed

    Yamanaka K., Kakuta Y., Miyagawa S., Nakazawa S., Kato T., Abe T., Imamura R., Okumi M., Maeda A., Mizuno M., Nonomura N.

    PlosOne   Vol. 11 ( 2 ) page: e0148881   2016

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    DOI: 10.1371/journal.pone.0148881. eCollection 2016.

  55. Rat Models of Acute and/or Chronic Peritoneal Injuries Including Peritoneal Fibrosis and Peritoneal Dialysis Complications

    Mizuno Masashi, Ito Yasuhiko

    KIDNEY RESEARCH: EXPERIMENTAL PROTOCOLS, 2ND EDITION   Vol. 1397   page: 35 - 43   2016

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    DOI: 10.1007/978-1-4939-3353-2_4

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  56. Vascular Endothelial Cell Injury Is an Important Factor in the Development of Encapsulating Peritoneal Sclerosis in Long-Term Peritoneal Dialysis Patients.

    Tawada M, Ito Y, Hamada C, Honda K, Mizuno M, Suzuki Y, Sakata F, Terabayashi T, Matsukawa Y, Maruyama S, Imai E, Matsuo S, Takei Y

    PloS one   Vol. 11 ( 4 ) page: e0154644   2016

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    DOI: 10.1371/journal.pone.0154644

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  57. Increase of Antimyeloperoxidase Antineutrophil Cytoplasmic Antibody (ANCA) in Patients with Renal ANCA-associated Vasculitis: Association with Risk to Relapse Reviewed International journal

    Yamaguchi Makoto, Ando Masahiko, Kato Sawako, Katsuno Takayuki, Kato Noritoshi, Kosugi Tomoki, Sato Waichi, Tsuboi Naotake, Yasuda Yoshinari, Mizuno Masashi, Ito Yasuhiko, Matsuo Seiichi, Maruyama Shoichi

    JOURNAL OF RHEUMATOLOGY   Vol. 42 ( 10 ) page: 1853 - 1860   2015.10

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    DOI: 10.3899/jrheum.141622

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  58. Vascular endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury.

    Terabayashi T, Ito Y, Mizuno M, Suzuki Y, Kinashi H, Sakata F, Tomita T, Iguchi D, Tawada M, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y

    Laboratory investigation; a journal of technical methods and pathology   Vol. 95 ( 9 ) page: 1029 - 43   2015.9

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    DOI: 10.1038/labinvest.2015.87

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  59. Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy.

    Sei Y, Mizuno M, Suzuki Y, Imai M, Higashide K, Harris CL, Sakata F, Iguchi D, Fujiwara M, Kodera Y, Maruyama S, Matsuo S, Ito Y

    Molecular immunology   Vol. 65 ( 2 ) page: 302 - 9   2015.6

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    DOI: 10.1016/j.molimm.2015.02.005

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  60. Calcified Amorphous Tumor in the Left Atrium in a Patient on Long-term Peritoneal Dialysis Reviewed

    Tanaka Akihito, Mizuno Masashi, Suzuki Yasuhiro, Oshima Hideki, Sakata Fumiko, Ishikawa Hideaki, Tsukushi Saori, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 54 ( 5 ) page: 481 - 485   2015

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    A 66-year-old woman with an 11-year history of peritoneal dialysis (PD) for diabetic nephropathy and renal failure exhibited a movable tumor in the left atrium on echocardiography. Tumor resection was performed due to the difficulty in diagnosing the tumor and the future risk of heart failure and embolization. Light microscopy showed a calcified amorphous tumor (CAT), a rare intracardiac mass characterized by the presence of a pedicle and diffuse calcification. An increased calcium-phosphate product level was suspected as an etiology, although degeneration, inflammation and/or mineral balance disorders may also induce the development of CAT. We herein report the first known case of CAT in a PD patient.<br>

    DOI: 10.2169/internalmedicine.54.2967

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  61. Calcified amorphous tumor in the left atrium of a patient on long-term peritoneal dialysis.

    Tanaka A., Mizuno M., Suzuki Y., Oshima H., Sakata F., Ishikawa H., Tsukushi S., Ito Y.

    Inten Med   Vol. 54   page: 481-485   2015

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    DOI: 10.2169/internalmedicine.54.3586.

  62. Smoking is a risk factor for the relapse of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

    Yamaguchi M., Ando M., Kato S., Katsuno T., Kato N., Kosugi T., Sato W., Tsuboi N., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S

    J Rheumatology     page: in press   2015

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  63. Vasuclar endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury.

    Terabayashi T, Ito Y, Mizuno M, Suzuki Y, Kinashi H, Sakata F, Tomita T, Iguchi D, Tawada M, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.

    Lab Invest     page: in press   2015

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  64. The efficacy of tolvaptan as a diuretic for chronic kidney disease patients. Reviewed

    Tanaka A., Katsuno T., Ozaki T., Sakata F., Kato N., Suzuki Y., Kosugi T., Kato S., Tsuboi N., Sato W., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S.

      Vol. 70   page: 217-223   2015

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    DOI: N/A

  65. Successful treatment of Cryptococcus laurentii peritonitis in a patient on peritoneal dialysis.

    Asano M, Mizutani M, Nagahara Y, Inagaki K, Kariya T, Masamoto D, Urai M, Kaneko Y, Ohno H, Miyazaki Y, Mizuno M, Ito Y

    Internal medicine (Tokyo, Japan)   Vol. 54 ( 8 ) page: 941 - 4   2015

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    A 32-year-old man on peritoneal dialysis (PD) was hospitalized for seven days due to fever. A diagnosis of yeast-like fungal peritonitis was made by Gram staining. The patient was started on intravenous micafungin and oral fluconazole therapy following removal of the PD catheter. A fungal pathogen was isolated from the peritoneal fluid and identified as <i>Cryptococcus</i> species. Based on antifungal susceptibility testing, the treatment was changed to voriconazole and continued for 3 months. A genetic analysis identified the isolate as <i>Cryptococcus laurentii</i> (<i>C. laurentii</i>). This patient was diagnosed with <i>C. laurentii</i> PD-related peritonitis and was successfully treated with voriconazole and removal of the PD catheter.<br>

    DOI: 10.2169/internalmedicine.54.3586

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  66. A case of difficult hemodialysis induction in a patient with acute intermittent porphyria

    Kojima Keitaro, Mizuno Masashi, Hattori Shinichi, Minoshima Kenichi, Yamaha Masayoshi, Horie Masanobu

    Nihon Toseki Igakkai Zasshi   Vol. 48 ( 7 ) page: 437 - 441   2015

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    A 45-year-old female with a history of chronic renal disease attended our hospital in 2008 with acute intermittent porphyria (AIP). The following year, her renal function deteriorated, and her general condition, and clinical and laboratory findings fulfilled the Japanese criteria for hemodialysis. The porphyrias are metabolic disorders of heme biosynthesis that are triggered and worsened by a number of different drugs. Hemodialysis was initiated in 2009, and we prescribed amlodipine besylate and epoetin beta, paying particular attention to drug safety. Currently, the patient is on hemodialysis and is still taking the medications mentioned above, without any exacerbation of porphyria.

    DOI: 10.4009/jsdt.48.437

  67. Patient Age and the Prognosis of Idiopathic Membranous Nephropathy

    Yamaguchi Makoto, Ando Masahiko, Yamamoto Ryohei, Akiyama Shinichi, Kato Sawako, Katsuno Takayuki, Kosugi Tomoki, Sato Waichi, Tsuboi Naotake, Yasuda Yoshinari, Mizuno Masashi, Ito Yasuhiko, Matsuo Seiichi, Maruyama Shoichi

    PLOS ONE   Vol. 9 ( 10 ) page: e110376   2014.10

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    DOI: 10.1371/journal.pone.0110376

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  68. Smoking Is a Risk Factor for the Progression of Idiopathic Membranous Nephropathy

    Yamaguchi Makoto, Ando Masahiko, Yamamoto Ryohei, Akiyama Shinichi, Kato Sawako, Katsuno Takayuki, Kosugi Tomoki, Sato Waichi, Tsuboi Naotake, Yasuda Yoshinari, Mizuno Masashi, Ito Yasuhiko, Matsuo Seiichi, Maruyama Shoichi

    PLOS ONE   Vol. 9 ( 6 ) page: e100835   2014.6

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    DOI: 10.1371/journal.pone.0100835

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  69. Long-term effects of spironolactone in peritoneal dialysis patients.

    Ito Y, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S, Nagoya Spiro Study Group.

    Journal of the American Society of Nephrology : JASN   Vol. 25 ( 5 ) page: 1094 - 102   2014.5

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    DOI: 10.1681/ASN.2013030273

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  70. Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation

    Kim Hangsoo, Mizuno Masashi, Furuhashi Kazuhiro, Katsuno Takayuki, Ozaki Takenori, Yasuda Kaoru, Tsuboi Naotake, Sato Waichi, Suzuki Yasuhiro, Matsuo Seiichi, Ito Yasuhiko, Maruyama Shoichi

    CYTOTHERAPY   Vol. 16 ( 3 ) page: 357 - 368   2014.3

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    DOI: 10.1016/j.jcyt.2013.10.011

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  71. Future Expectations of Diagnostic Approaches for Treating Endogenous Peritonitis in Patients on Peritoneal Dialysis. Invited Reviewed

    Mizuno M., Suzuki Y., Ito Y.

    Internal Medicine     page: in press   2014

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  72. Rat adipose tissue-derived stromal cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation. Reviewed

    Kim H., Mizuno M., Furuhashi K., Katsuno T., Ozaki T., Yasuda K., Tsuboi N., Sato W., Suzuki Y., Matsuo S., Ito Y., Maruyama S.

    Cytotherapy     page: in press   2014

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  73. Long-term effects of spironolactone in peritoneal dialysis patients. Reviewed

    Ito Y., Mizuno M., Suzuki Y., Tamai G., Hiramatsu T.,Ohashi H., Ito I., Kasuga H., Horie M., Maruyama S., Yuzawa Y., Matsubara T., Matsuo S, Nagoya Spiro Study Group.

    J Am Soc Nephrol     page: in press   2014

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  74. Smoking is a risk factor for the progression of idiopathic membranous nephropathy. Reviewed

    Yamaguchi M., Ando M., Yamamoto R., Akiyama S., Kato S., Katsuno T., Kosugi T., Sato W., Tsuboi N., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S.

    PloS One   Vol. 9 ( 6 ) page: e100835   2014

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  75. Patient age and the prognosis of idiopathic membrane nephropathy. Reviewed

    Yamaguchi M., Ando M., Yamamoto R., Akiyama S., Kato S., Katsuno T., Kosugi T., Sato W., Tsuboi N., Yasuda Y., Mizuno M., Ito Y., Matsuo S., Maruyama S.

    ProsOne   Vol. 9 ( 10 ) page: e110376   2014

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  76. Future Expectations of Diagnostic Approaches for Treating Endogenous Peritonitis in Patients on Peritoneal Dialysis Reply Invited Reviewed International journal

    Mizuno Masashi, Suzuki Yasuhiro, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 53 ( 6 ) page: 647 - 647   2014

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    DOI: 10.2169/internalmedicine.53.1827

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  77. Anti-C5a complementary peptide ameliorates acute peritoneal injury induced by neutralization of Crry and CD59.

    Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y

    American journal of physiology. Renal physiology   Vol. 305 ( 11 ) page: F1603 - 16   2013.12

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    DOI: 10.1152/ajprenal.00681.2012

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  78. TGF-β1 promotes lymphangiogenesis during peritoneal fibrosis.

    Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y

    Journal of the American Society of Nephrology : JASN   Vol. 24 ( 10 ) page: 1627 - 42   2013.10

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    DOI: 10.1681/ASN.2012030226

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  79. An autopsy case of Clostridium perfringens peritonitis on CAPD related to malignant mesothelioma

    ASANO Marina, INAGAKI Koji, KARIYA Tetsuyoshi, ASANO Shuichi, MASAMOTO Daijiro, MIZUTANI Makoto, TAKAHASHI Yohei, MIZUNO Masashi, ITO Yasuhiko

    Nihon Toseki Igakkai Zasshi   Vol. 46 ( 9 ) page: 949 - 954   2013.9

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    A 74-year-old man with nephrosclerosis had been treated with CAPD since 2007, until he passed away in 2011. He was admitted to our hospital three times in June, July, and November 2010 due to bacterial peritonitis. In each episode, he responded to antibiotic treatment. In January 2011, he was again admitted to the hospital due to peritonitis. Abdominal CT showed a tumor mass in the upper pole of the spleen and multiple intra-abdominal nodules. Despite highly suspected malignancy, a biopsy was not performed due to his poor state. In March 2011, he was admitted to the hospital again (his fifth hospital admission) due to peritonitis. His clinical condition deteriorated progressively and he passed away on the day of admission. <I>Clostridium perfringens</I> and <I>Streptococcus mitis</i> were identified as the pathogens of the peritonitis by culture of CAPD fluid. The result of the autopsy proved that multiple intra-abdominal nodules were the peritoneal seeding of malignant mesothelioma. Although bacterial peritonitis was ultimately the cause of his death, malignant mesothelioma may be considered as the proximate cause of the peritonitis. Herewith, we present this case as an interesting and rare case in terms of the pathogenesis.

    DOI: 10.4009/jsdt.46.949

  80. Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats. Reviewed

    Katsuno T., Osaki T., Saka Y., Furuhashi K., Kim H., Yasuda K., Yamamoto T., Sato W., Tsuboi N., Mizuno M., Ito Y., Imai E., Matsuo S., Maruyama S.

    Cell Transplant   Vol. 22 ( 2 ) page: 287-297   2013

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  81. Clostridium perfringensによるCAPD関連腹膜炎と悪性中皮腫の関連が示唆された1剖検例. Reviewed

    1. 浅野麻里奈、稲垣浩司、狩谷哲芳、浅野周一、政本大二郎、水谷真、高橋洋平、水野正司、伊藤恭彦

    日本透析医学会雑誌   Vol. 46 ( 9 ) page: 949-954   2013

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  82. TGF-β1 promotes lymphangiogenesis during peritoneal fibrosis. Reviewed

    Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.

    Journal of American Society of Nephrology   Vol. 24 ( 10 ) page: 1627-1642   2013

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  83. Perforative peritonitis caused by appendicitis in a patient on peritoneal dialysis. Reviewed

    Mizuno M, Suzuki Y, Nonaka K, Sei Y, Maruyama S, Matsuo S, Ito Y.

    Internal Medicine   Vol. 52 ( 11 ) page: 1177-1181   2013

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  84. Low Serum Cultured Adipose Tissue-Derived Stromal Cells Ameliorate Acute Kidney Injury in Rats

    Katsuno Takayuki, Ozaki Takenori, Saka Yosuke, Furuhashi Kazuhiro, Kim Hangsoo, Yasuda Kaoru, Yamamoto Tokunori, Sato Waichi, Tsuboi Naotake, Mizuno Masashi, Ito Yasuhiko, Imai Enyu, Matsuo Seiichi, Maruyama Shoichi

    CELL TRANSPLANTATION   Vol. 22 ( 2 ) page: 287 - 297   2013

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    DOI: 10.3727/096368912X655019

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  85. Perforative Peritonitis caused by Appendicitis in a Patient on Peritoneal Dialysis

    Mizuno Masashi, Suzuki Yasuhiro, Nonaka Keisuke, Sei Yumi, Maruyama Shoichi, Matsuo Seiichi, Ito Yasuhiko

    INTERNAL MEDICINE   Vol. 52 ( 11 ) page: 1177 - 1181   2013

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    A 46-year-old man on peritoneal dialysis (PD) was hospitalized due to suspicious PD-related peritonitis. Because the patient's abdominal pain was unimproved by conventional antibiotics and multiple bacteria were identified in a smear-sample of PD fluid, endogenous peritonitis was suspected. Perforated appendicitis was finally diagnosed under exploratory laparotomy. In this patient, perforated appendicitis was difficult to diagnose due to the attenuated clinical symptoms and inconclusive results of abdominal computed tomography (CT), even though the positive predictive value of CT is >95% in non-PD patients. Quickly deciding to perform exploratory laparotomy in patients suspected of having endogenous peritonitis is thus important, even when the origin has not been clarified.<br>

    DOI: 10.2169/internalmedicine.52.9196

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  86. Guideline for hereditary angioedema (HAE) 2010 by the Japanese Association for Complement Research - secondary publication. Invited Reviewed International journal

    Horiuchi T, Ohi H, Ohsawa I, Fujita T, Matsushita M, Okada N, Seya T, Yamamoto T, Endo Y, Hatanaka M, Wakamiya N, Mizuno M, Nakao M, Okada H, Tsukamoto H, Matsumoto M, Inoue N, Nonaka M, Kinoshita T, Japanese Association for Complement Research.

    Allergology international : official journal of the Japanese Society of Allergology   Vol. 61 ( 4 ) page: 559 - 62   2012.12

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    This guideline was provided by the Japanese Association for Complement Research targeting clinicians for making an accurate diagnosis of hereditary angioedema (HAE), and for prompt treatment of the HAE patient in Japan. This is a 2010 year version and will be updated according to any pertinent medical advancements.<br>

    DOI: 10.2332/allergolint.12-RAI-0471

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  87. Rat adipose tissue-derived stromal cells in a low serum medium attenuate peritoneal injuries in rat zymosan-induced peritonitis

    Kim Hangsoo, Mizuno Masashi, Furuhashi Kazuhiro, Katsuno Takayuki, Ozaki Takenori, Yasuda Kaoru, Tsuboi Naotake, Imai Enyu, Matsuo Seiichi, Ito Yasuhiko, Maruyama Shoichi

    IMMUNOBIOLOGY   Vol. 217 ( 11 ) page: 1197 - 1197   2012.11

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    DOI: 10.1016/j.imbio.2012.08.194

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  88. Short-term Administration of Diclofenac Sodium Affects Renal Function After Laparoscopic Radical Nephrectomy in Elderly Patients

    Mizuno Tomohiro, Ito Kazuma, Miyagawa Yasuhiro, Ishikawa Kazuhiro, Suzuki Yasuhiro, Mizuno Masashi, Ito Yasuhiko, Funahashi Yasuhito, Hattori Ryohei, Gotoh Momokazu, Yamada Kiyofumi, Noda Yukihiro

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 42 ( 11 ) page: 1073 - 1078   2012.11

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    DOI: 10.1093/jjco/hys145

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  89. A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin

    ITO Isao, ITO Yasuhiko, MIZUNO Masashi, SUZUKI Yasuhiro, YASUDA Kaoru, OZAKI Takenori, KOSUGI Tomoki, YASUDA Yoshinari, SATO Waichi, TSUBOI Naotake, MARUYAMA Shoichi, IMAI Enyu, MATSUO Seiichi

    Clinical and experimental nephrology   Vol. 16 ( 3 ) page: 490 - 494   2012.6

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  90. A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin

    Ito Isao, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Yasuda Kaoru, Ozaki Takenori, Kosugi Tomoki, Yasuda Yoshinari, Sato Waichi, Tsuboi Naotake, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 16 ( 3 ) page: 490 - 494   2012.6

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    DOI: 10.1007/s10157-012-0620-8

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  91. Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis

    Toda Susumu, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Ito Isao, Hiramatsu Hideki, Ozaki Takenori, Tsuboi Naotake, Sato Waichi, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 27 ( 6 ) page: 2511 - 2516   2012.6

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    DOI: 10.1093/ndt/gfr685

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  92. Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction.

    Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, Noda Y, Mizuno T, Shimizu H, Fujita Y, Matsui K, Maruyama S, Imai E, Matsuo S, Takei Y

    Kidney international   Vol. 81 ( 9 ) page: 865 - 79   2012.5

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    DOI: 10.1038/ki.2011.464

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  93. Adequate administration of darbepoetin alfa improves renal anemia in Japanese peritoneal dialysis patients for whom the maximum dose of recombinant human erythropoietin did not fully achieve improved anemia

    HIRAMATSU Hideki, HAYASHI Hiroki, MIZUNO Masashi, SUZUKI Yasuhiro, TODA Susumu, ITO Isao, MARUYAMA Shoichi, ITO Yasuhiko, MATSUO Seiichi

    Nihon Toseki Igakkai Zasshi   Vol. 45 ( 3 ) page: 247 - 253   2012.3

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    Although the maximum approved dosage of recombinant human erythropoietin (rHuEPO) is 24,000IU/month in patients on peritoneal dialysis (PD) therapy in Japan, the improvement of renal anemia is not always satisfactorily maintained at a blood hemoglobin (Hb) level>10.0g/dL. Among 46 patients on PD therapy in our hospital, we investigated the effects of darbepoetin alfa (DA) in 8 patients (DA group) with Hb<10.0g/dL after the administration of rHuEPO at 12,000IU/2 weeks, compared with the 38 other patients (non-DA group) with Hb>10.0g/dL after the administration of rHuEPO at a dose<12,000IU/2 weeks. In terms of background data, the residual renal function was lower and serum&beta;<SUB>2</SUB> microglobulin level was higher in the DA group, compared with the non-DA group. As an inflammatory marker, the serum C-reactive protein level was also higher in the DA group than in the non-DA group. After 18 weeks of DA administration instead of rHuEPO, the mean (&plusmn;standard deviation) Hb level increased to 11.0&plusmn;0.8g/dL. The Hb level eventually reached>10.0g/dL in all patients using DA instead of rHuEPO. Of note, serum ferritin levels in all 46 patients were within the normal range, suggesting that low iron storage was not a direct reason for anemia in this study. The present results suggest that renal anemia in patients on PD therapy who remained inadequately managed using the maximum approved dosage of rHuEPO was caused by an inadequate dosage of rHuEPO, and might be controlled to target levels using an adequate dosage of DA.

    DOI: 10.4009/jsdt.45.247

  94. Atrial natriuretic peptide ameliorates peritoneal fibrosis in rat peritonitis model Reviewed

    Kato Hiroshi, Mizuno Tomohiro, Mizuno Masashi, Sawai Akiho, Suzuki Yasuhiro, Kinashi Hiroshi, Nagura Fumiko, Maruyama Shoichi, Noda Yukihiro, Yamada Kiyofumi, Matsuo Seiichi, Ito Yasuhiko

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 27 ( 2 ) page: 526 - 536   2012.2

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    DOI: 10.1093/ndt/gfr302

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  95. Aliskiren-induced chyloperotoneum in a patient on peritoneal dialysis. et al. A case report. Reviewed

    Saka Y, Tachi H, Sakurai H, Tawada M, Sawai A, Shimamura Y, Mizuno M, Maruyama S, Matsuo S, Ito Y.

    Perit Dial Int   Vol. 32   page: 111-113   2012

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  96. Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. Reviewed

    Toda S., Ito Y., Mizuno M., Suzuki Y., Ito I., Hiramatsu H., Ozaki T., Tsuboi N., Sato W., Maruyama S., Imai E., Matsuo S.

    Nephrol Dial Tranplant   Vol. 27   page: 2511-2516   2012

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  97. Atrial natriuretic peptide ameliorates peritoneal fibrosis in a rat peritonitis model. Reviewed

    Kato H., Mizuno T., Mizuno M., Sawai A., Suzuki Y., Kinashi H., Nagura F., Maruyama S., Noda Y., Yamada K., Matsuo S., Ito Y.

    Nephrol. Dial. Transplant.   Vol. 27   page: 526-536   2012

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  98. Renal impairment after laparoscopic radical nephrectomy affects hypoglycemic therapy. Reviewed

    Mizuno T., Ito K., Miyagawa Y., Kimura K., Suzuki K., Mizuno M., Ito Y., Funabashi Y., Hattori R., Gotoh M., Noda Y., Yamada K.

    J. Clin Pharm Therapy   Vol. 37   page: 49-52   2012

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  99. Guideline for hereditary angioedema (HAE) 2010 by the Japanese association for complement research. Invited Reviewed

    Horiuchi T., Ohi H., Ohsawa I., Fujita T., Matsushita M., Okada N., Seya T., Yamamoto T., Endo Y., Hatanaka M., Wakamiya N., Mizuno M., Nakao M., Okada H., Tsukamoto H., Matsumoto M., Inoue N., Nonaka M., Kinoshita T.

    Allergol Int   Vol. 61 ( 4 ) page: 559-562   2012

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  100. Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomu in elderly patients. Reviewed

    Mizuno T., Ito K., Miyagawa Y., Ishikawa K., Suzuki Y., Mizuno M., Ito Y., Funabashi Y., Hattori R., Gotoh M., Yamada K., Noda Y.

    Jpn J Clin Oncol   Vol. 42 ( 11 ) page: 1073-1078   2012

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  101. Exploiting the nephrotoxic effects of venom from the sea anemone, Phyllodiscus semoni, to create a hemolytic uremic syndrome model in the rat. Invited Reviewed

    Mizuno M., Ito Y, Morgan BP.

    Marine Drugs   Vol. 10   page: 1582-1604   2012

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  102. Combined values of serum albumin, C-reactive protein and body mass index at dialysis initiation accurately predicts log-term mortality. Reviewed

    Takahashi R., Ito Y., Takahashi H., Ishii H., Kasuga H., Mizuno M., Suzuki Y., Yuzawa Y., Maruyama S., Murohara T., Imai E., Matsuo S.

    Am J Nephrol   Vol. 36   page: 136-143   2012

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  103. A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin. Reviewed

    Ito I., Ito Y., Mizuno M., Suzuki Y., Yasuda K., Ozaki T., Kosugi T., Yasuda Y., Sato Y., Tsuboi N., Maruyama S., Imai E., Matsuo S.

    Clin Exp Nephrol   Vol. 16   page: 490-494   2012

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  104. Membrane complement regulators protect against fibrin exudation in a severe peritoneal inflammation model in rats. Reviewed

    Mizuno M., Ito Y., Mizuno T., Suzuki Y., Harris CL., Okada N, Matsuo S, Morgan BP.

    Am J Physil Renal Physiol   Vol. 302   page: F1245-F1251   2012

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  105. Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction. Reviewed

    Suzuki Y., Ito Y., Mizuno M., Kinashi H., Sawai A., Noda Y., Mizuno T., Shimizu H., Fujita Y., Matsui K., Maruyama S., Imai E., Matsuo S., Takei Y.

    Kidney Int.   Vol. 81   page: 865-879   2012

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  106. 遺伝子組換えヒトエリスロポエチンによる赤血球造血刺激因子製剤療法低反応性腹膜透析患者の持続型赤血球層血刺激因子製剤Darbepoetin Alfa投与の効果 Reviewed

    平松英樹、林祐樹、水野正司、鈴木康弘、戸田晋、伊藤功、丸山彰一、伊藤恭彦、松尾清一

    日本透析医学会会誌   Vol. 45   page: 247-253   2012

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  107. 腹膜組織における補体活性化の観点からみた、現在の透析液の問題

    水野正司、伊藤恭彦、鈴木康弘、松尾清一

    腎と透析 2012 (腎と透析 別冊)   Vol. 73   page: 109-110   2012

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  108. 各論2 腹膜透析ガイドライン, 3. 腹膜炎管理 ISPDガイドラインを本邦の実地臨床にいかに活用するか?本邦のガイドラインをいかにすべきか? Invited

    伊藤恭彦、水野正司、鈴木康弘、清祐実、平松英樹、松尾清一

    臨床透析   Vol. 28   page: 856-864   2012

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  109. 至摘透析・体液管理, 腹膜透析における小・中・大分子量物質除去と腹膜機能の関連性

    5. 平松英樹、伊藤恭彦、水野正司、鈴木康弘、戸田晋、坪井直毅、伊藤功、佐藤和一、丸山彰一、今井圓裕、林裕樹、松尾清一

    腎と透析 2012 (腎と透析 別冊)   Vol. 73   page: 235-236   2012

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  110. IV. 課題と対策(2)腹膜炎 - 名古屋大学関連施設レジストリーからみたPD腹膜炎の問題点. Invited

    伊藤恭彦、水野正司、鈴木康弘、他

    臨床と透析   Vol. 28   page: 571-577   2012

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  111. Aliskiren-Induced Chyloperitoneum in a Patient on Peritoneal Dialysis Reviewed International journal

    Saka Y., Tachi H., Sakurai H., Tawada M., Sawai A., Shimamura Y., Mizuno M., Maruyama S., Matsuo S., Ito Y.

    PERITONEAL DIALYSIS INTERNATIONAL   Vol. 32 ( 1 ) page: 111 - U123   2012

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    DOI: 10.3747/pdi.2011.00049

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  112. Combined values of serum albumin, C-reactive protein and body mass index at dialysis initiation accurately predicts long-term mortality.

    Takahashi R, Ito Y, Takahashi H, Ishii H, Kasuga H, Mizuno M, Suzuki Y, Yuzawa Y, Maruyama S, Murohara T, Imai E, Matsuo S

    American journal of nephrology   Vol. 36 ( 2 ) page: 136 - 43   2012

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    DOI: 10.1159/000339940

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  113. A case of perforative peritonitis caused by a piece of bamboo in a patient on peritoneal dialysis

    SUZUKI Yasuhiro, MIZUNO Masashi, NAKASHIMA Ryoko, HIRAMATSU Hideki, TODA Susumu, SATO Waichi, TSUBOI Naotake, ITO Isao, MARUYAMA Shoichi, IMAI Enyu, MATSUO Seiichi, ITO Yasuhiko

    Clinical and experimental nephrology   Vol. 15 ( 6 ) page: 962 - 965   2011.12

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  114. A case of perforative peritonitis caused by a piece of bamboo in a patient on peritoneal dialysis

    Suzuki Yasuhiro, Mizuno Masashi, Nakashima Ryoko, Hiramatsu Hideki, Toda Susumu, Sato Waichi, Tsuboi Naotake, Ito Isao, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi, Ito Yasuhiko

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 15 ( 6 ) page: 962 - 965   2011.12

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    DOI: 10.1007/s10157-011-0529-7

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  115. Effects of cinacalcet on magnesium and potassium metabolism in peritoneal dialysis patients with residual renal function

    SHIBATA Kanako, ITO Yasuhiko, MIZUNO Masashi, SUZUKI Yasuhiro, HIRAMATSU Hideki, ITO Isao, TODA Susumu, MARUYAMA Shoichi, MATSUO Seiichi

    Nihon Toseki Igakkai Zasshi   Vol. 44 ( 10 ) page: 1007 - 1013   2011.10

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    Cinacalcet, a calcimimetic agent, binds to the calcium-sensing receptor (CaSR) and effectively decreases parathyroid hormone (PTH) secretion. CaSR is expressed in organs such as the parathyroid, kidneys, and bone. In the kidneys, it is expressed in the thick ascending limb (TAL) and the distal tubule (DT). In the TAL, activation of CaSR inhibits magnesium and calcium resorption by direct or indirect mechanisms. It also inhibits recycling of potassium back into the lumen by potassium channels. Peritoneal dialysis (PD) is thought to preserve the residual renal function (RRF) longer than hemodialysis. RRF is thus an important prognostic factor for PD patients. We investigated the effects on electrolyte balance and safety of cinacalcet. Six PD patients with RRF received once-daily oral cinacalcet at 25mg for two months. We examined the changes in levels of serum iPTH, and serum and urinary excretion of phosphorus, calcium, magnesium, and potassium for two months. Median (interquatile range: IQR) serum iPTH levels decreased significantly from 427.2 (351.2~1,313.3) pg/mL to 234.4 (86.0~721.3) pg/mL. Serum phosphorus levels and urinary excretion of phosphorus also decreased significantly. In contrast, concentrations of serum calcium, magnesium, and potassium, and urinary excretion of calcium, magnesium, and potassium did not change significantly. Serum levels of magnesium and potassium were not significantly altered, and were within the normal ranges (before, median 2.2 (IQR: 1.9~2.3) mg/dL, after, median 2.0 (IQR: 1.8~2.5) mg/dL for Mg; and before, median 4.5 (IQR: 4.4~5.2) mEq/L to 4.6 (IQR: 4.2~4.8) mEq/L for K). Based on these findings regarding the potassium and magnesium balance, cinacalcet appears to be useful and safe for the treatment of secondary hyperparathyroidism in PD patients with RRF.

    DOI: 10.4009/jsdt.44.1007

  116. Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan

    MIZUNO Masashi, ITO Yasuhiko, TANAKA Akio, SUZUKI Yasuhiro, HIRAMATSU Hideki, WATANABE Midoriko, TSURUTA Yoshikazu, MATSUOKA Teppei, ITO Isao, TAMAI Hiroshi, KASUGA Hirotake, SHIMIZU Hideaki, KURATA Hisashi, INAGUMA Daijo, HIRAMATSU Takeyuki, HORIE Masanobu, NARUSE Tomohiko, MARUYAMA Shoichi, IMAI Enyu, YUZAWA Yukio, MATSUO Seiichi

    Clinical and experimental nephrology   Vol. 15 ( 5 ) page: 727 - 737   2011.10

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  117. Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan.

    Mizuno M, Ito Y, Tanaka A, Suzuki Y, Hiramatsu H, Watanabe M, Tsuruta Y, Matsuoka T, Ito I, Tamai H, Kasuga H, Shimizu H, Kurata H, Inaguma D, Hiramatsu T, Horie M, Naruse T, Maruyama S, Imai E, Yuzawa Y, Matsuo S

    Clinical and experimental nephrology   Vol. 15 ( 5 ) page: 727 - 737   2011.10

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    DOI: 10.1007/s10157-011-0471-8

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  118. Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. Reviewed

    Sawai A, Ito Y, Mizuno M, Suzuki Y, Toda S, Ito I, Hattori R, Matsukawa Y, Gotoh M, Takei Y, Yuzawa Y, Matsuo S

      Vol. 26 ( 7 ) page: 2322-2332   2011.7

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  119. Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients

    Sawai Akiho, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Toda Susumu, Ito Isao, Hattori Ryohei, Matsukawa Yoshihisa, Gotoh Momokazu, Takei Yoshifumi, Yuzawa Yukio, Matsuo Seiichi

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 26 ( 7 ) page: 2322 - 2332   2011.7

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    DOI: 10.1093/ndt/gfq702

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  120. Specific collaboration between rat membrane complement regulators Crry and CD59 protects peritoneum from damage by autologous complement activation.

    Mizuno T, Mizuno M, Morgan BP, Noda Y, Yamada K, Okada N, Yuzawa Y, Matsuo S, Ito Y

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   Vol. 26 ( 6 ) page: 1821 - 30   2011.6

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    DOI: 10.1093/ndt/gfq683

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  121. Lymphangiogenesis develop during tubulo-interstitial fibrosis via TGF-beta VEGF-C pathway in rat unilateral ureteral obstruction. Reviewed

    Suzuki Y, Ito Y, Mizuno M, Sawai A, Kinashi H, Noda Y, Kato H, Shimizu H, Fujita Y, Matsui K, Imai E, Yuzawa Y, Matsuo S, Takei Y.

    Kidney Int   Vol. ??? in press   page: ????????   2011

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  122. Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. Reviewed

    Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

    Nephrol Dial Transplant   Vol. ??   page: ?????? in press   2011

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  123. A case of perforative peritonitis by a piece of bamboo in a patient on peritoneal dialysis. Reviewed

    Suzuki Y., Mizuno M., Nakashima R., Hiramatsu H., Toda S., Sato W., Tsuboi N., Ito I., Maruyama S., Imai E., Matsuo S., Ito Y.

    Clin Exp Nephrol   Vol. 15   page: 962-965   2011

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  124. A case of acute renal failure caused by cholesterol embolization after carotid artery stenting that was improved by peritoneal dialysis. Reviewed

    Mizuno M., Ito Y., Hayasaki T., Suzuki Y., Hiramatsu H., Toda S., Tatematsu M., Ozaki T., Sato W., Tsuboi N., Ito I., Marumaya S., Imai E., Matsuo S.

    Intern Med   Vol. 50   page: 1719-1723   2011

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  125. A case of fulminant peritonitis caused by Streptococcus mitis in a patient on peritoneal dialysis. Reviewed

    Mizuno M., Ito Y, Masuda T, Toda S, Hiramatsu H, Suzuki Y, Ozaki T, Yasuda Y, Ito I, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

    Intern Med   Vol. 50   page: 471-474   2011

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  126. A case of acute renal failure caused by cholesterol embolization after carotid artery stenting that was improved by peritoneal dialysis. Reviewed

    Mizuno M., Ito Y., Hayasaki T., Suzuki Y., Hiramatsu H., Toda S., Tatematsu M., Ozaki T., Sato W., Tsuboi N., Ito I., Marumaya S., Imai E., Matsuo S.

    Intern Med   Vol. 50   page: 1719-1723   2011

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  127. 腹膜透析にかかわる腹膜組織障害における補体の関与 Invited

    水野正司、伊藤恭彦、松尾清一

    医学のあゆみ   Vol. 239   page: 779-783   2011

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  128. 残腎機能を有する腹膜透析患者に対するシナカルセト投与時のMg、K代謝に及ぼす影響 Reviewed

    柴田佳菜子、伊藤恭彦、水野正司、鈴木康弘、平松英樹、伊藤功、戸田晋、丸山彰一、中尾誠、松尾清一

    日本透析医学会会誌   Vol. 44   page: 1007-1013   2011

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  129. Case of Fulminant Peritonitis Caused by Streptococcus mitis in a Patient on Peritoneal Dialysis Reviewed International journal

    Mizuno Masashi, Ito Yasuhiko, Masuda Tomohiro, Toda Susumu, Hiramatsu Hideki, Suzuki Yasuhiro, Ozaki Takenori, Yasuda Yoshinari, Ito Isao, Tsuboi Naotake, Sato Waichi, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi

    INTERNAL MEDICINE   Vol. 50 ( 5 ) page: 471 - 474   2011

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    A 54-year-old woman on peritoneal dialysis (PD) was hospitalized with peritonitis with a high body temperature, abdominal pain and cloudy peritoneal fluid. She progressively fell into septic-like shock within only 6 hours after onset. The causative bacteria were <i>Streptococcus mitis</i> (<i>S. mitis</i>), part of the normal flora of oral cavity, intestine, female genial tract and upper respiratory tract. <i>S. mitis</i> shows pathogenicity for diseases such as endocarditis, brain abscesses and sepsis in children with malignancy or transplantation. However, <i>S. mitis</i> rarely shows severe pathogenic responses in adults. We report herein a case of fulminant peritonitis caused by <i>S. mitis</i> in an adult PD patient.<br>

    DOI: 10.2169/internalmedicine.50.4122

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  130. A Case of Acute Renal Failure Caused by Cholesterol Embolization after Carotid Artery Stenting that was Improved by Peritoneal Dialysis

    Mizuno Masashi, Ito Yasuhiko, Hayasaki Takahiro, Suzuki Yasuhiro, Hiramatsu Hideki, Toda Susumu, Mizuno Tomohiro, Tatematsu Miho, Ozaki Takenori, Yasuda Yoshinari, Sato Waichi, Tsuboi Naotake, Ito Isao, Maruyama Shoichi, Imai Enyu, Matsuo Seiichi

    INTERNAL MEDICINE   Vol. 50 ( 16 ) page: 1719 - 1723   2011

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    A 68-year-old man was admitted with acute renal failure caused by cholesterol embolization after undergoing carotid artery stenting. Hemodialysis therapy (HD) was immediately required because of uremia, using nafamostat mesilate as an anticoagulant for HD. However, blue toes and gangrene of the feet worsened. To prevent use of anticoagulants and stabilize BP, HD was changed to peritoneal dialysis (PD). After starting PD, blue toes and gangrene improved markedly. Residual renal function also partially recovered. Although BP was unstable during HD, stability of BP and avoidance of anticoagulants during PD therapy might have contributed to the good results.<br>

    DOI: 10.2169/internalmedicine.50.5358

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  131. Pathological changes in chronic eosinophilic peritonitis in peritoneal dialysis patient.

    Yuzawa Y, Ito Y, Mizuno M, Sawai A, Matsuo S

    NDT plus   Vol. 3 ( 4 ) page: 372 - 5   2010.8

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    DOI: 10.1093/ndtplus/sfq080

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  132. [Recent knowledge of complement system and the protective roles]. Invited

    Mizuno M, Matsuo S

    Nihon rinsho. Japanese journal of clinical medicine   Vol. 68 Suppl 6   page: 49 - 52   2010.6

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  133. Connective tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate.

    Mizutani M, Ito Y, Mizuno M, Nishimura H, Suzuki Y, Hattori R, Matsukawa Y, Imai M, Oliver N, Goldschmeding R, Aten J, Krediet RT, Yuzawa Y, Matsuo S

    American journal of physiology. Renal physiology   Vol. 298 ( 3 ) page: F721 - 33   2010.3

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    DOI: 10.1152/ajprenal.00368.2009

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  134. Connective tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate. Reviewed

    Mizutani M, Ito Y, Mizuno M, Nishimura H, Suzuki Y, Hattori R, Matsukawa Y, Imai M, Oliver N, Goldschmeding R, Aten J, Krediet RT, Yuzawa Y, Matsuo S.

    Am J Physiol Renal Physiol   Vol. 298 ( F721-F733 )   2010

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  135. Recent knowledge of complement system and the protective roles. Invited

    Mizuno M, Matsuo S.

    Nippon Rinsho   Vol. 68   page: 49-52   2010

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  136. Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia. Reviewed

    Yuzawa Y, Sato W, Masuda T, Hamada Y, Tatematsu M, Yasuda Y, Ozaki T, Ito I, Mizuno M, Maruyama S, Ito Y, Matsuo S.

    Intern Med   Vol. 49   page: 1139-1142   2010

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  137. 名大腎不全システム研究会レジストリによる東海地区13施設の3年間(2005~2007)解析から得た、現在の腹膜透析療法の傾向と問題点

    2. 水野正司、伊藤恭彦、田中章郎、平松英樹、渡辺緑子、稲熊大城、戸田晋、檀原敦、玉井宏史、倉田久嗣、春日弘毅、志水英明、松岡哲平、鶴田吉和、堀江正宣、成瀬友彦、平松武幸、伊藤功、丸山彰一、湯澤由紀夫、松尾清一

    腎と透析 2010 (腎と透析 別冊)   Vol. 69   page: 638-640   2010

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  138. 基礎カンファレンス 腹膜線維化に関する基礎研究の進歩, 腹膜線維症・機能不全と成長因子 特にTGF-β/CTGF/VEGFからの検討

    3. 伊藤恭彦、水野正司、水谷真、西村勇人、鈴木康弘、澤井晶穂、鬼無洋、湯澤由紀夫、松尾清一

    腎と透析 2010(腎と透析 別冊)   Vol. 69   page: 128-131   2010

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  139. Acute Kidney Injury Presenting a Feature of Leukemic Infiltration during Therapy for Chronic Myelogenous Leukemia

    Yuzawa Yukio, Sato Waichi, Masuda Tomohiro, Hamada Yuzuru, Tatematsu Miho, Yasuda Yoshinari, Ozaki Takenori, Ito Isao, Mizuno Masashi, Maruyama Shoichi, Ito Yasuhiko, Matsuo Seiichi

    INTERNAL MEDICINE   Vol. 49 ( 12 ) page: 1139 - 1142   2010

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    Chronic myelogenous leukemia (CML) is a myeloproliferative disease that originates in abnormal pluripotent bone marrow stem cells and it is consistently associated with the Philadelphia chromosome and/or BCR/ ABL fusion gene. Renal infiltration of leukemic cells is relatively rare in CML and is associated with renal impairment. We describe a patient who developed acute renal failure by tubulointerstitial nephropathy during treatment with imatinib mesylate for CML. The acute kidney injury was subsequently found to be due to direct leukemic infiltration. Treatment with hydroxycarbamide and prednisolone resulted in stabilization of the renal function for approximately 4 months. Leukemic infiltration into the kidney should always be considered when a patient with CML presents with renal impairment, regardless of the clinical stage, as the renal failure often responds well to chemotherapy.<br>

    DOI: 10.2169/internalmedicine.48.2747

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  140. Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice

    Kurata Kei, Maruyama Shoichi, Kato Sawako, Sato Waichi, Yamamoto Jun-ichiro, Ozaki Takenori, Nitta Atsumi, Nabeshima Toshitaka, Morita Yoshiki, Mizuno Masashi, Ito Yasuhiko, Yuzawa Yukio, Matsuo Seiichi

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   Vol. 297 ( 6 ) page: F1510 - F1517   2009.12

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    DOI: 10.1152/ajprenal.90330.2008

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  141. Zymosan, but not lipopolysaccharide, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model.

    Mizuno M, Ito Y, Hepburn N, Mizuno T, Noda Y, Yuzawa Y, Harris CL, Morgan BP, Matsuo S

    Journal of immunology (Baltimore, Md. : 1950)   Vol. 183 ( 2 ) page: 1403 - 12   2009.7

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    DOI: 10.4049/jimmunol.0804245

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  142. Lymphatic vessels develop during tubulointerstitial fibrosis

    Sakamoto Izumi, Ito Yasuhiko, Mizuno Masashi, Suzuki Yasuhiro, Sawai Akiho, Tanaka Akio, Maruyama Shoichi, Takei Yoshifumi, Yuzawa Yukio, Matsuo Seiichi

    KIDNEY INTERNATIONAL   Vol. 75 ( 8 ) page: 828 - 838   2009.4

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    DOI: 10.1038/ki.2008.661

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  143. Lymphatic vessels develop during tubulointerstitial fibrosis. Reviewed

    Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Tanaka A, Maruyama S, Takei Y, Yuzawa Y, Matsuo S.

    Kidney Int   Vol. 75   page: 828-838   2009

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  144. Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. Reviewed

    Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S.

    Am J Physiol Renal Physiol   Vol. 297 ( F1510-1517 )   2009

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  145. The role of membrane complement regulators in the normal peritoneal cavity

    Mizuno Tomohiro, Mizuno Masashi, Ito Yasuhiko, Matsuo Seiiti, Noda Yukihiro

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 109   page: 59P - 59P   2009

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  146. Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model

    Nishimura Hayato, Ito Yasuhiko, Mizuno Masashi, Tanaka Akio, Morita Yoshiki, Maruyama Shoichi, Yuzawa Yukio, Matsuo Seiichi

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY   Vol. 294 ( 5 ) page: F1084 - F1093   2008.5

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    DOI: 10.1152/ajprenal.00565.2007

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  147. The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility. Reviewed

    Donev RM., Sivasankar B., Mizuno M., Morgan BP.

    Mol. Immunol.   Vol. 45   page: 534-542   2008.1

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  148. The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility.

    Donev RM, Sivasankar B, Mizuno M, Morgan BP

    Molecular immunology   Vol. 45 ( 2 ) page: 534 - 42   2008.1

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    DOI: 10.1016/j.molimm.2007.05.011

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  149. Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. Reviewed

    Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S.

    Am J Physiol Renal Physiol   Vol. 294   page: F1084-F1093   2008

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  150. 『特集 アシドーシスとアルカローシス』 代謝性酸塩基平衡異常における治療の基本とその方法 Invited

    伊藤恭彦、水野正司

    薬局   Vol. 59   page: 42-47   2008

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  151. 本邦のCAPD療法の現況 – CAPD療法に対する取り組み 大学・教育病院の役割 Invited

    伊藤恭彦、水野正司、丸山彰一、湯澤 由紀夫、松尾清一

    臨床透析   Vol. 24   page: 205-210   2008

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  152. A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a renal injury resembling haemolytic uremic syndrome. Reviewed

    Mizuno M., Nozaki M., Morine N., Suzuki N., Nishikawa K., Morgan BP., Matsuo S.

    Am. J. Pathol.   Vol. 171   page: 402-414   2007.8

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    Envenomation by the sea anemone Phyllodiscus semoni causes fulminant dermatitis and, rarely, acute renal failure in humans. Here, we investigated whether the venom extracted from the nematocysts (PsTX-T) was nephrotoxic when administered intravenously in rats and whether PsTX-T induced activation of the complement system. Although small dose of PsTX-T induced acute tubular necrosis in rats resembling pathology seen in patients, kidneys displayed glomerular injury with glomerular endothelial damage, thrombus formation, mesangiolysis, and partial rupture of glomerular basement membrane, accompanied by severe tubular necrosis at 24 hours after administration of 0.03 mg of PsTX-T per animal, similar to the glomerular findings typical of severe hemolytic uremic syndrome. The early stage injury was accompanied by specific PsTX-T binding, massive complement C3b, and membrane attack complex deposition in glomeruli in the regions of injury and decreased glomerular expression of complement regulators. A pathogenic role for complement was confirmed by demonstrating that systemic complement inhibition reduced renal injury. The isolated nephrotoxic component, a 115-kd protein toxin (PsTX-115), was shown to cause identical renal pathology. The demonstration that PsTX-T and PsTX-115 were highly nephrotoxic acting via induction of complement activation suggests that inhibition of complement might be used to prevent acute renal damage following envenomation by P. semoni.

  153. A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a severe renal injury with predominant glomerular endothelial damage. Reviewed International coauthorship International journal

    Mizuno M, Nozaki M, Morine N, Suzuki N, Nishikawa K, Morgan BP, Matsuo S

    The American journal of pathology   Vol. 171 ( 2 ) page: 402 - 14   2007.8

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    DOI: 10.2353/ajpath.2007.060984

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  154. Immunization with autologous CD46 generates a strong autoantibody response in rats that targets spermatozoa. Reviewed International coauthorship International journal

    Mizuno M, Harris CL, Morgan BP

    Journal of reproductive immunology   Vol. 73 ( 2 ) page: 135 - 147   2007.4

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    DOI: 10.1016/j.jri.2006.08.001

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  155. CD55 in rat male reproductive tissue: differential expression in testis and expression of a unique truncated isoform on spermatozoa. Reviewed International coauthorship International journal

    Mizuno M, Donev RM, Harris CL, Morgan BP

    Molecular immunology   Vol. 44 ( 7 ) page: 1613 - 22   2007.3

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    DOI: 10.1016/j.molimm.2006.08.018

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  156. High levels of complement C3a receptor in the glomeruli of inflamed human lupus nephritis. Reviewed

    Mizuno M., Blanchin S., Gasque P., Nishikawa K., Matsuo S.

    Am. J. Kidney Dis.   Vol. 49   page: 598-606   2007

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    BACKGROUND: Taking into consideration the key role of the complement system in renal diseases, we investigated molecular and cellular properties of the human complement C3a receptor (C3aR) in vitro and in situ, looking at its expression in several human renal pathological states. METHODS: Several antibodies were generated and used for immunohistochemistry and Western blot analyses to address C3aR expression and its regulation in vitro on cell lines of myeloid cells and nonmyeloid cell lineages. Furthermore, C3aR distribution was investigated in control nephrectomized kidneys and 116 biopsy specimens from patients with renal diseases, including lupus nephritis (lupus-N). RESULTS: C3aR is a highly N-glycosylated protein with an apparent molecular mass of 65 to 95 kd expressed by myeloid and endothelial cells. C3aR is particularly upregulated in response to interferon gamma treatment, but was unaffected by the other inflammatory cytokines, such as tumor necrosis factor alpha and transforming growth factor beta. In normal human kidney, C3aR staining was not observed. However, glomerular C3aR staining was detected in 42.9% of lupus-N specimens in association with immunoglobulin G immune-complex depositions. Staining intensity correlated with disease severity. C3aR was found in the endothelial area of 81.3% of samples classified as World Health Organization class IV with active lesions. Conversely, C3aR was not detected by means of immunohistochemistry in kidneys from patients with other renal diseases. CONCLUSION: Our data indicate that C3aR expression is tightly regulated and altered in certain disease conditions. C3aR may be used as a unique biomarker of diagnosis and disease activity in patients with lupus-N.

  157. よく使う利尿薬について習熟する スピロノラクトン Invited

    水野正司、伊藤恭彦

    Medicina   Vol. 44   page: 359-342   2007

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  158. Immunization with autologous CD46 in rats generates a strong autoantibody response that targets spermatozoa. Reviewed

    Mizuno M., Harris CL., Morgan BP.

    J. Reprod. Immunol.   Vol. 73   page: 135-147   2007

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  159. 【特集:これだけは知っておきたい分子腎臓学2007】 C5a. Invited

    水野正司、湯澤由紀夫、松尾清一

    腎と透析   Vol. 63   page: 580-582   2007

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  160. Spermatogenic cells distal to the blood-testis barrier in rats lack C3 convertase regulators and may be at risk of complement-mediated injury.

    Mizuno M, Harris CL, Morgan BP

    Journal of reproductive immunology   Vol. 69 ( 1 ) page: 23 - 34   2006.2

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    DOI: 10.1016/j.jri.2005.11.002

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  161. Complement and complement regulators in the male reproductive system.

    Harris CL, Mizuno M, Morgan BP

    Molecular immunology   Vol. 43 ( 1-2 ) page: 57 - 67   2006.1

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    DOI: 10.1016/j.molimm.2005.06.026

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  162. The membrane attack pathway of complement drives pathology in experimental autoimmune myasthenia gravis in mice. Reviewed

    Morgan BP., Chamberlain-Banoub J., Neal JW.,Song W., Mizuno M., Harris CL.

    Clin Exp Immunol   Vol. 146   page: 294-302   2006

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  163. Complement and complement regulators in the male reproductive system. Invited Reviewed

    Harris CL., Mizuno M., Morgan BP.

    Mol Immunol   Vol. 43   page: 57-67   2006

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  164. Complement membrane attack is required for endplate damage and clinical disease in experimental myasthenia gravis in Lewis rats. Reviewed

    Chamberlain-Banoub J., Neal JW., Mizuno M., Harris CL., Morgan BP.

    Clin Exp Immunol   Vol. 146   page: 278-286   2006

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  165. CD55 expression in rat male reproductive tissue: Differential expression in testis and expression of a unique truncated isoform on spermatozoa. Reviewed

    Mizuno M., Donev RM., Harris CL., Morgan BP.

    Mol. Immunol.   Vol. 44   page: 1624-1633   2006

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  166. A review of current knowledge of the complement system and the therapeutic opportunities in inflammatory arthritis. Invited Reviewed

    Mizuno M.

    Curr Med Chem   Vol. 13   page: 1707-1717   2006

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  167. Unique expression patterns of membrane complement regulators and C3 in rat testes and spermatozoa delineate the blood-testis barrier and suggest distinct functional roles in germ cell development. Reviewed

    Mizuno M., Harris CL., Morgan BP.

    J Reprod Immunol   Vol. 69   page: 23-34   2006

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  168. Shiga toxin 1 causes direct renal injury in rats.

    Yamamoto ET, Mizuno M, Nishikawa K, Miyazawa S, Zhang L, Matsuo S, Natori Y

    Infection and immunity   Vol. 73 ( 11 ) page: 7099 - 106   2005.11

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    DOI: 10.1128/IAI.73.11.7099-7106.2005

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  169. CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells. Invited International coauthorship

    Elward K, Griffiths M, Mizuno M, Harris CL, Neal JW, Morgan BP, Gasque P

    The Journal of biological chemistry   Vol. 280 ( 43 ) page: 36342 - 54   2005.10

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    DOI: 10.1074/jbc.M506579200

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  170. Novel C5a regulators in inflammatory disease.

    Mizuno M, Cole DS

    Expert opinion on investigational drugs   Vol. 14 ( 7 ) page: 807 - 21   2005.7

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    DOI: 10.1517/13543784.14.7.807

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  171. Expression of CD46 in developing rat spermatozoa: Ultrastructural localization and utility as a marker of the various stages of the seminiferous tubuli Reviewed International coauthorship International journal

    Mizuno M, Harris CL, Suzuki N, Matsuo S, Morgan BP

    BIOLOGY OF REPRODUCTION   Vol. 72 ( 4 ) page: 908 - 915   2005.4

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    DOI: 10.1095/biolreprod.104.035485

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  172. Expression of CD46 in developing rat spermatozoa: ultrastructural localisation and utility as a marker of the various stages of the seminiferous tubuli. Reviewed

    Mizuno M., Harris CL., Suzuki N., Matsuo S., Morgan BP.

    Biol Reprod   Vol. 72   page: 908-915   2005

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  173. Shiga toxin-1 causes direct renal injury in rats. Reviewed

    Yamamoto ET., Mizuno M., Nishikawa K., Miyazawa S., Zhang L., Matsuo S., Natori Y.

    Infect Immun   Vol. 73   page: 7099-7106   2005

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  174. Novel C5a regulators in inflammation. Invited Reviewed

    Mizuno M., Cole DS.

    Expert Opin Investig Drugs   Vol. 14   page: 807-821   2005

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  175. Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3.

    Mizuno M, Harris CL, Johnson PM, Morgan BP

    Biology of reproduction   Vol. 71 ( 4 ) page: 1374 - 83   2004.10

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    DOI: 10.1095/biolreprod.104.030114

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  176. CD59a is the primary regulator of membrane attack complex assembly in the mouse.

    Baalasubramanian S, Harris CL, Donev RM, Mizuno M, Omidvar N, Song WC, Morgan BP

    Journal of immunology (Baltimore, Md. : 1950)   Vol. 173 ( 6 ) page: 3684 - 92   2004.9

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    DOI: 10.4049/jimmunol.173.6.3684

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  177. The possibilities and pitfalls for anti-complement therapies in inflammatory diseases. Invited Reviewed

    Mizuno M., Morgan BP.

    Current Drug Targets Inflammation & Allergy   Vol. 3   page: 85-94   2004

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  178. CD59a is the primary regulator of membrane attack complex assembly in the mouse. Reviewed

    Baalasubramanian S., Harris CL., Donev RM., Mizuno M., Omidvar N., Song W., Morgan BP.

    J. Immunol.   Vol. 173   page: 3684-3692   2004

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  179. Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3. Reviewed

    Mizuno M., Harris CL., Johnson PM., Morgan BP.

    Biol Reprod   Vol. 71   page: 1374-1383   2004

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  180. Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. Reviewed

    Williams AS., Mizuno M., Richards PJ., Holt DS., Morgan BP

    Arthritis Rheum   Vol. 50   page: 3035-3044   2004

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  181. In two patients on long-term hemodialysis, Etidronate Disodium improved their discomfort and extremities' blood flow associated with severe abnormal arterial wall calcification. Reviewed

    Mizuno M., Kashima N., Kato K., Ito A, Matsuo S.

    Clin Drug Invest   Vol. 24   page: 365-371   2004

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  182. Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo. Reviewed International coauthorship International journal

    Fraser DA, Harris CL, Williams AS, Mizuno M, Gallagher S, Smith RA, Morgan BP

    The Journal of biological chemistry   Vol. 278 ( 49 ) page: 48921 - 7   2003.12

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    DOI: 10.1074/jbc.M302598200

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  183. Implication of the complement system in the induction of antiglomerular basement membrane glomerulonephritis in WKY rats

    SHIKE Tatsuhiko, ISOME Masato, MIZUNO Masashi, SUZUKI Junzo, MATSUO Seiichi, YAMAMOTO Tadashi, SUZUKI Hitoshi

    Pathology international   Vol. 53 ( 11 ) page: 757 - 761   2003.11

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  184. Implication of the complement system in the induction of anti-glomerular basement membrane glomerulonephritis in WKY rats.

    Shike T, Isome M, Mizuno M, Suzuki J, Matsuo S, Yamamoto T, Suzuki H

    Pathology international   Vol. 53 ( 11 ) page: 757 - 61   2003.11

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    DOI: 10.1046/j.1440-1827.2003.01555.x

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  185. The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids

    LIU Man-Chang, MARUYAMA Shoichi, MIZUNO Masashi, MORITA Yoshiki, HANAKI Shigeru, YUZAWA Yukio, MATSUO Seiichi

    Clinical and experimental nephrology   Vol. 7 ( 3 ) page: 186 - 194   2003.9

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  186. The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids.

    Liu MC, Maruyama S, Mizuno M, Morita Y, Hanaki S, Yuzawa Y, Matsuo S

    Clinical and experimental nephrology   Vol. 7 ( 3 ) page: 186 - 94   2003.9

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    DOI: 10.1007/s10157-003-0229-z

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  187. Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison.

    Harris CL, Hanna SM, Mizuno M, Holt DS, Marchbank KJ, Morgan BP

    Immunology   Vol. 109 ( 1 ) page: 117 - 26   2003.5

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    DOI: 10.1046/j.1365-2567.2003.01628.x

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  188. Non-dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients.

    Liu M, Takahashi H, Morita Y, Maruyama S, Mizuno M, Yuzawa Y, Watanabe M, Toriyama T, Kawahara H, Matsuo S

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   Vol. 18 ( 3 ) page: 563 - 9   2003.3

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    DOI: 10.1093/ndt/18.3.563

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  189. Non-dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients. Reviewed

    Liu M., Takahashi H., Morita Y., Maruyama S., Mizuno M., Yuzawa Y., Watanabe M., Toriyama T., Kawahara H., MatsuoS.

    Nephrol Dial Transplant.   Vol. 18   page: 563-569   2003

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  190. Implication of the complement system in the induction of anti-glomerular basement membrane glomerulonephritis in WKY rats. Pathol. Reviewed

    Shike T., Isome M., Mizuno M., Suzuki J., Matsuo S., Yamamoto T., Suzuki H.

    Pathol. Int.   Vol. 53   page: 757-761   2003

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    Language:English   Publishing type:Research paper (scientific journal)  

  191. The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. Reviewed

    Liu MC., Maruyama S., Mizuno M., Morita Y., Hanaki S., Yuzawa Y., Matsuo, S.

    Clin Exp Nephrol   Vol. 7   page: 186-194   2003

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  192. Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison. Reviewed

    Harris CL., Hanna SM., Mizuno M., Holt DS., Marchbank KJ., Morgan BP.

    Immunology   Vol. 109   page: 117-126   2003

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  193. Nephrogenic diabetes insipidus associated with hemochromatosis.

    Okumura A, Kondo K, Hirai C, Nishimura H, Tamai H, Kawarazaki F, Ichikawa M, Mizuno M, Oiso Y, Yamamoto M

    American journal of kidney diseases : the official journal of the National Kidney Foundation   Vol. 40 ( 2 ) page: 403 - 6   2002.8

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    DOI: 10.1053/ajkd.2002.34540

    PubMed

  194. P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction.

    Naruse T, Yuzawa Y, Akahori T, Mizuno M, Maruyama S, Kannagi R, Hotta N, Matsuo S

    Kidney international   Vol. 62 ( 1 ) page: 94 - 105   2002.7

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    DOI: 10.1046/j.1523-1755.2002.00419.x

    PubMed

  195. The use of polysulfone hemodialysis membrane may improve hyperlipemia in patients receiving long-term maintenance hemodialysis

    MIZUNO Masashi, KOBAYASHI Kaoru, NAKATA Atsuhiro, WATANABE Midoriko, TORIYAMA Takanobu, KAWAHARA Hirohisa, MATSUO Seiichi

      Vol. 35 ( 1 ) page: 43 - 49   2002.1

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  196. Soluble complement receptor type 1 protects rats from lethal shock induced by anti-Crry antibody following lipopolysaccharide priming

    Mizuno M, Nishikawa K, Okada N, Matsuo S, Okada H

    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY   Vol. 127 ( 1 ) page: 55 - 62   2002.1

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  197. Soluble complement receptor type 1 protects rats from lethal shock induced by anti-Crry antibody following lipopolysaccharide priming.

    Mizuno M, Nishikawa K, Okada N, Matsuo S, Okada H

    International archives of allergy and immunology   Vol. 127 ( 1 ) page: 55 - 62   2002.1

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    DOI: 10.1159/000048169

    PubMed

  198. 高脂血症を伴う長期維持血液透析患者におけるポリスルフォン膜(PS-UW)の有用性について Reviewed

    水野正司、小林薫、中田淳博、渡辺緑子、鳥山高伸、川原弘久、松尾清一

    日本透析医学会雑誌   Vol. 35   page: 43-49   2002

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  199. 二次性副甲状腺機能亢進症に対するmaxacalcitorol(オキサロールR)静注パルス療法の効果 ―早期低用量使用の試みー Reviewed

    渡辺緑子、中田敦博、八島影人、河出恭雅、佐藤悌、小杉智規、鳥山高伸、河原弘久、水野正司、森田良樹、松尾清一

    日本透析医学会誌   Vol. 35   page: 1193-1250   2002

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  200. Soluble CR1 protects rats from lethal shock induced by anti-Crry antibody following LPS priming. Reviewed

    Mizuno M., Nishikawa K., Okada N., Mastuo S., Okada H.

    Internal. Arch. Allergy Immunol.   Vol. 127   page: 55-62   2002

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  201. Nephrogenic diabetes insipidus associated with hemochromatosis. Reviewed

    Okumura A., Kondo K., Hirai C., Nishimura H., Tamai H., Kawarazaki F., Ichikaraki M., Mizuno M., Oiso Y., Yamamoto M.

    Am J Kidney Dis   Vol. 40   page: 403-406   2002

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  202. P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction. Reviewed

    Naruse T., Yuzawa Y., Akahori T, Mizuno M., Maruyama S., Kannagi R., Hotta S., Matsuo S.

    Kidney Int.   Vol. 62   page: 94-105   2002

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  203. The effects of low-dose intravenous maxacalcitol therapy on mild secondary hyperparathyroidism.

    Watanabe Midoriko, Morita Yoshiki, Matsuo Seiichi, Nakata Atsuhiro, Yashima Akihito, Kawade Yasumasa, Sato Yasushi, Kosugi Tomoki, Toriyama Takanobu, Kawahara Hirohisa, Mizuno Masashi

    Nihon Toseki Igakkai Zasshi   Vol. 35 ( 8 ) page: 1193 - 1198   2002

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    This study evaluated the effects of low-dose i. v. maxacalcitol (OXAROL<sup>&reg;</sup> OCT) in controlling mild secondary hyperparathyroidism (II&deg; HPT) in chronic hemodialysis patients. Nineteen patients were selected for treatment because of increased parathyroid hormone (PTH) levels de spite administration of vitamin D (VD). The patients consisted of 15 males and 4 females, and were divided into 2 groups based on serum intact-PTH (i-PTH) levels (group I; N=11, 240pg/mL&le;i-PTH<360pg/mL, group II; N=8, 360pg/mL&le;i-PTH<500pg/mL). After a 2-week wash-out period for oral VD, OCT was given intravenously at a dose of 2.5&mu;g in group I and 5.0&mu;g in group II at the end of dialysis therapy 3 times/week. The dose was adjusted to maintain serum i-PTH levels at 240-500pg/mL and normal calcium (Ca) levels. During the 48-week observation period, serum i-PTH decreased significantly in both groups. Serum Ca levels increased mildly in both groups, but they remained within the normal range. Serum levels of phosphorus, ALP, bone ALP and osteocalcin were not significantly changed in either group. There was no correlation between parathyroid gland volume and i-PTH level. These findings suggest that long-term intravenous treatment with low-dose OCT is a useful strategy for the treatment of mild II&deg; HPT without significant increase of serum Ca.

    DOI: 10.4009/jsdt.35.1193

  204. The use of polysulfone hemodialysis membrane may improve hyperlipemia in patients receiving long-term maintenance hemodialysis.

    Mizuno Masashi, Kobayashi Kaoru, Nakata Atsuhiro, Watanabe Midoriko, Toriyama Takanobu, Kawahara Hirohisa, Matsuo Seiichi

    Nihon Toseki Igakkai Zasshi   Vol. 35 ( 1 ) page: 43 - 49   2002

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    Ischemic heart disease, cerebral hemorrhage, and cerebral embolus are severe complications seen in patients on maintenance hemodialysis. Hyperlipidemia is one of the risk factors profoundly associated with these complications. We investigated whether the use of polysulfone (PS) hemodialysis membrane improved serum levels of some lipid components in 6 non-DM patients on long-term maintenance hemodialysis. These 6 non-DM patients (one treated with CTA-membrane, 5 with EVAL-membrane) had hyperlipidemia (total cholesterol (TC) 263&plusmn;17mg/dL, triglyceride (TG) 176&plusmn;20mg/dL). Three patients were administered 5mg/day of Pravastatin sodium as an anti-hyperlipidemic drug, and one received 20mg/day of the same drug. We measured serum levels of TC, TG, LDL-C, HDL-C, LDL-TG, HDL-TG, Apo-A1, Apo-C3 and other factors before and 1 week after, then 1, 3, 5 and 6 months after the change in hemodialysis membrane. The serum TC level started to decrease after changing the membrane, and it decreased to 212&plusmn;8mg/dL 3 months after that. Serum levels of LDL-C, Apo-A1 and Apo-C3 had significantly decreased at 6 months after the use of PS-membrane. However, serum levels of HDL-C and TG saw no change after the use of PS-membrane.<br>In addition, we tried to decrease or stop anti-hyperlipidemic drugs 6 months after the change in hemodialysis membrane when serum levels of TC had decreased and remained under 200mg/dL. One of the subjects did not need any drugs associated with hyperlipidemia. Another needed to have an anti-hyperlipidemic drug readministered about 4 months after the drug had been stopped.<br>In the present study, the PS-membrane might improve the hyperlipidemic profiles in patients on long-term hemodialysis. It was suggested that the use of PS-membrane might be available to decrease the dosage of antihyperlipidemia drugs or stop the administration of these drugs in hyperlipidemic patients on maintenance hemodialysis.

    DOI: 10.4009/jsdt.35.43

  205. The role of C5a in the development of thrombotic glomerulonephritis in rats

    Kondo C, Mizuno M, Nishikawa K, Yuzawa Y, Hotta N, Matsuo S

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   Vol. 124 ( 2 ) page: 323 - 329   2001.5

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  206. Glomerulocystic kidney associated with subacute necrotizing-encephalomyelopathy

    Yamakawa T, Yoshida F, Kumagai T, Watanabe H, Takano A, Mizuno M, Ikeguchi H, Morita Y, Sobue G, Matsuo S

    AMERICAN JOURNAL OF KIDNEY DISEASES   Vol. 37 ( 2 )   2001.2

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    DOI: 10.1053/ajkd.2001.21358

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  207. 【Innate immunity】 臨床 補体制御因子と疾患 Reviewed

    松尾清一, 水野正司

    現代医療   Vol. 33   page: 1011-1016   2001

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  208. 【尿蛋白と尿細管障害】 尿中補体成分と尿細管障害 Invited

    松尾清一, 森田良樹, 水野正司

    細胞   Vol. 33   page: 12-15   2001

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  209. Glomerulocystic Kidney Associated With Subacute Necrotizing-Encephalomyelopathy. Reviewed

    Yamakawa T., Yoshida H., Kumagai T., Watanabe H., Takano A., Mizuno M., Ikeguchi H., Morita Y., Sobue G., Matsuo S.

    Am. J. Kidney Dis.   Vol. 37   page: E14   2001

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  210. Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. Reviewed

    Bardenstein SD., Cheyer JC, Lee C., Cocuzzi E., Mizuno M., Okada N., Medof EM.

    Immunology   Vol. 104   page: 423-430   2001

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  211. Membrane complement regulators protect against the development of type II collagen-induced arthritis (CIA) in rats. Reviewed

    Mizuno M., Nishikawa K., Spiller OB., Morgan BP., Okada N., Okada H., Matsuo S.

    Arthritis Rheum.   Vol. 44   page: 2425-2434   2001

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  212. The effects of a new synthetic selectin blocker in an acute rat thrombotic glomerulonephritis. Reviewed

    Ito I., Yuzawa Y., Mizuno M., Nishikawa K., Jomori T., Tashita A., Hotta N., Matsuo S.

    Am. J. Kidney Dis.   Vol. 38   page: 265-273   2001

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  213. The Role of C5a in The Development of Thrombotic Glomerulonephritis in Rats. Reviewed

    Kondo C., Mizuno M., Nishikawa K., Yuzawa Y., Hotta N., Matsuo S.

    Clin. Exp. Immunol.   Vol. 124   page: 323-329   2001

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  214. Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcR gamma-deficient mice

    Wakayama H, Hasegawa Y, Kawabe T, Hara T, Matsuo S, Mizuno M, Takai T, Kikutani H, Shimokata K

    EUROPEAN JOURNAL OF IMMUNOLOGY   Vol. 30 ( 4 ) page: 1182 - 1190   2000.4

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  215. Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced in rats by blocking of CD59 Reviewed International coauthorship

    Mizuno M, Nishikawa K, Morgan BP, Matsuo S

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   Vol. 119 ( 2 ) page: 368 - 375   2000.2

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  216. A case report of acute renal failure following a sting presumedly by a sea anemone. Reviewed

    Mizuno M., Nishikawa K., Yuzawa Y., Kanie T., Mori H., Araki Y., Hotta N., Matsuo S.

    Am. J. Kidney Dis.   Vol. 36   page: E10   2000

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    A 27-year-old man suffering from severe swelling and pain in his right arm was referred to our hospital. He showed signs of acute renal failure (ARF) with severe dermatitis of his right arm. Three days before being admitted, he accidentally touched some kind of marine organism with his right hand while snorkeling in the Sulu Sea around Cebu Island. Within a few minutes, he was experiencing severe pain in his right hand. Then his right hand gradually became swollen. The marine creature responsible for this injury was thought to have been a sea anemone, which is a type of coelenterate. Histologic findings of a renal biopsy indicated that acute tubular necrosis (ATN) had caused ARF in this patient's case. Supportive therapies improved renal function of this patient, and steroid pulse therapy attenuated the severe skin discoloration. The ATN was thought to have been caused by the poison from a sea anemone because there were no other conceivable reasons for the patient's condition. This is the first time that a marine envenomation case has been reported in which the sting of a sea anemone has caused ATN without the failure of any other organs.

  217. 【腎臓病の分子生物学】 腎障害のメディエータ 補体制御による進行性腎疾患治療の可能性

    松尾清一, 水野正司

    医学のあゆみ   Vol. 193   page: 32-35   2000

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  218. 【急性腎不全の全て-2000】 病因・病態 急性腎不全とサイトカイン Invited

    松尾清一, 水野正司

    腎と透析   Vol. 49   page: 373-376   2000

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  219. Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced by anti-rat CD59 antibody. Reviewed

    Mizuno M., Nishikawa K., Morgan B.P., Matsuo S.

    Clin. Exp. Immunol.   Vol. 119   page: 368-375   2000

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  220. The role of complement in the progression of renal fibrosis: a clinical study. Invited Reviewed

    Matsuo S., Morita Y., Mizuno M., Nishikawa K., Yuzawa Y.

    Nephrol. Dial. Transplant.   Vol. 15   page: 53-54   2000

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  221. CD59 protects kidneys from complement mediated injury in collaboration with Crry in rats. Reviewed

    Watanabe M., Morita Y., Mizuno M., Nishikawa K., Yuzawa Y., Hotta N., Morgan B.P., Okada N., Okada H., Matsuo S.

    Kidney Int.   Vol. 58   page: 1569-1579   2000

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  222. Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice. Reviewed

    Wakayama H., Hasegawa Y., Kawabe T., Hara T., Matsuo S., Mizuno M., Takai T., Kikutani H., Shimokata K.

    Eur. J. Immunol.   Vol. 30   page: 1182-1190   2000

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  223. The role of complement in the progression of renal fibrosis: a clinical study

    Matsuo S, Morita Y, Mizuno M, Nishikawa K, Yuzawa Y

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 15   page: 53 - 54   2000

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  224. Direct Gram staining of blood culture sample enabled the early diagnosis of brain abscess due to Listeria monocytogenes

    TAKANO Akemi, ADACHI Hiroaki, MIZUNO Masashi, KAWAMURA Kumiko, SOBUE Gen

    Rinsho Shinkeigaku (Clin Neurol)   Vol. 39 ( 11 ) page: 1164 - 1167   1999.11

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  225. Inhibition of a membrane complement regulatory protein by a monoclonal antibody induces acute lethal shock in rats primed with lipopolysaccharide Reviewed International coauthorship International journal

    Mizuno M, Nishikawa K, Okada N, Matsuo S, Ito K, Okada H

    JOURNAL OF IMMUNOLOGY   Vol. 162 ( 9 ) page: 5477 - 5482   1999.5

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  226. 血液培養サンプルのグラム染色により早期診断が可能であったリステリア脳膿瘍の1例 Reviewed

    高野明美, 足立弘明, 水野正司, 川村久美子, 祖父江元

    臨床神経学   Vol. 39   page: 1164-1167   1999

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  227. Functional inhibition of a membrane complement regulatory protein induces lethal shock in rats primed with trace levels of lipopolysaccharide. Reviewed

    Mizuno M., Nishikawa K., Okada N., Mastuo S., Okada H., Ito K., Okada H.

    J. Immunol.   Vol. 162   page: 5477-5482   1999

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  228. Complement-Mediated Renal Injury: Mechanisms and Role of Membrane Regulators of Complement Invited Reviewed International journal

    MATSUO Seiichi, MORITA Yoshiki, MIZUNO Masashi, NISHIKAWA Kazuhiro, YUZAWA Yukio

    Clinical and experimental nephrology   Vol. 2 ( 4 ) page: 276 - 281   1998.12

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  229. Proteinuria and damage to tubular cells - is complement a culprit?

    Matsuo S, Morita Y, Mizuno M, Nishikawa K, Yuzawa Y

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 13 ( 11 ) page: 2723 - 2726   1998.11

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  230. Proteinuria and damage to tubular cells-is complement a culprit? (共著) Invited

    Nephrol. Dial. Transplant.   Vol. 13   page: 2723-2726   1998

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  231. 血栓形成性腎炎におけるC5a Receptor(C5a-R)antagonistの効果 Invited

    水野正司, 西川和裕, 松尾清一

    腎臓   Vol. 20   page: 21-23   1998

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  232. 急性腎不全をきたした腔腸動物刺傷症の1例

    蟹江多美、森聖、富田靖、水野正司、松尾清一

    皮膚科の臨床   Vol. 40   page: 1223-1226   1998

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  233. Complement mediated renal injury : Its mechanisms and role of membrane regulators of complement. (共著) Reviewed

    Clin. Exp. Nephrol.   Vol. 2   page: 276-281   1998

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  234. C5a played key roles in the formation of thrombi in experimental glomerulonephritis.

    Mizuno M, Nishikawa K, Miyakawa K, Hotta N, Matsuo S

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   Vol. 8   page: A2141 - A2141   1997.9

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  235. The effects of functional supression of a membrane-bound complement regulatory protein, CD59, in the synovial tissue in rats. Reviewed

    Arthritis & Rheumatism   Vol. 40   page: 527-533   1997

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  236. Role of a rat membrane inhibitor of complement in anti-basement membrane antibody-induced renal injury. Reviewed

    Kidney International   Vol. 48   page: 1728-1738   1995

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  237. Pathogenic significance of interleukin-6 in a patient with antiglomerular basement membrane antibody-induced glomerulonephritis with multinucleated giant cells. Reviewed

    Americal Journal of Kidney Disease   Vol. 26   page: 72-79   1995

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  238. A case of renal sarcoidosis showing central necrosis and abdominal expression of angiotensin converting enzyme in the granuloma. Reviewed

    Clinical Nephrology   Vol. 42   page: 331-336   1994

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  239. 維持血液透析患者における心房性ナトリウム利尿ペプチドおよびcyclic GMPの臨床的意義--特に心胸比高値のdry weightの決定における有用性について-- Reviewed

    水野正司、伊藤恭彦、鈴木高志、馬場美香、市田静憲、坂本信夫、松尾清一

    日本透析医学会誌   Vol. 27   page: 1295-1301   1994

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  240. 脊髄損傷透析患者の臨床的検討 Reviewed

    伊藤恭彦、鈴木高志、水野正司、森田良樹、市田静憲、宮川幸一郎、松尾清一

    日本透析医学会誌   Vol. 26   page: 1745-1750   1993

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Books 10

  1. プロフェッショナル腎臓病・9 膜性増殖性糸球体腎炎とC3腎症

    坪井直毅、水野正司(9)( Role: Joint author)

    中外医学社  2020.9  ( ISBN:978-4-498-22462-9

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    Total pages:619   Language:Japanese Book type:Textbook, survey, introduction

  2. 腹膜透析研修テキスト・第4章 維持期管理

    水野正司( Role: Joint author)

    特定非営利活動法人 日本腹膜透析医学会  2020.9 

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    Total pages:86   Language:Japanese Book type:Textbook, survey, introduction

  3. The Renal Drug Handbook 第4版 腎臓内科医のための究極の処方ガイド-日本語版-

    志水英明、田中章郎、他( Role: Joint author)

    株式会社 じほう  2018.12  ( ISBN:978-4-8407-5154-4

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    Total pages:1025   Language:Japanese Book type:Scholarly book

  4. Clinical Toxinology . Nephrotoxic Effects of Venoms from Sea Anemones from Japan.

    Masashi Mizuno( Role: Joint author)

    Springer  2018 

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    Language:English Book type:Scholarly book

  5. The Cnidaria, past, present and future. The world of medusa and her sisters. Chapter 38. Envenomation by cnidarians and renal injuries.

    Masashi Mizuno( Role: Joint author)

    Springer  2016 

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    Language:English Book type:Dictionary, encyclopedia

  6. Methods Mol Biol. Kidney Research Experimental Protocol 2nd ed. Chapter 4. Rat models of acute and/or chronic peritoneal injuries including peritoneal fibrosis and peritoneal dialysis complications.

    Mizuno M, Ito Y( Role: Sole author)

    Humana Press  2016 

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    Total pages:292   Language:Japanese Book type:Scholarly book

  7. 補体学への招待、8-1 腎尿細管間質障害と補体

    松尾清一、水野正司( Role: Joint author)

    メジカルビュー社  2011 

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    Language:Japanese

  8. 補体学への招待、7-4 血液透析と補体

    水野正司( Role: Joint author)

    メジカルビュー社  2011 

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  9. 腎不全 腎不全進行と補体

    松尾清一, 森田良樹, 水野正司( Role: Joint author)

    Annual Review腎臓1999巻  1999 

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    Language:Japanese

  10. 異物識別と生体反応-新しい視点を求めて-Bio Defenceシリーズ3 8章 膜補体制御因子機能抑制による補体活性化と炎症反応 (共著)

    西川和裕、水野正司、松尾清一、岡田則子、岡田秀親( Role: Joint author)

    日本生体防御学会  1998 

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Presentations 4

  1. CASES OF ACUTE APPENDICITIS IN PATIENTS ON PERITONEAL DIALYSIS (PD) IN A SINGLE CENTRE DURING 15 YEARS International conference

    Mizuno Masashi, Suzuki Yasuhiro, Kojima Hiroshi, Sato Yuka, Kinashi Hiroshi, Katsuno Takayuki, Maruyama Shoichi, Ito Yasuhiko

    NEPHROLOGY  2020.10 

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  2. Development of encapsular peritoneal sclerosis (EPS)-like peritonitis in rat and complement activation International coauthorship International conference

    Iguchi Daiki, Mizuno Masashi, Shigemoto Emi, Sakata Fumiko, Suzuki Yasuhiro, Okada Alan, Okada Hidechika, Maruyama Shoichi, Matsuo Seiichi, Ito Yasuhiko

    MOLECULAR IMMUNOLOGY  2015.9 

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  3. ANALYSIS OF FREQUENCY AND KINDS OF ALARM HISTORIES OF HOME PD SYSTEM KAGUYA DURING THE INTRODUCTION: PERIOD IN A SINGLE CENTRE

    Hiramatsu Tetsuaki, Mizuno Masasi, Suzuki Yasuhiro, Nomori Sumiyo, Suzuki Masafumi, Shiga Yoshiko, Sato Yuka, Nakamura Tomohiro, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Koyama Tomio

    NEPHROLOGY  2020.10 

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  4. CASES OF ACUTE APPENDICITIS IN PATIENTS ON PERITONEAL DIALYSIS (PD) IN A SINGLE CENTRE DURING 15 YEARS International coauthorship International conference

    Mizuno Masashi, Suzuki Yasuhiro, Kojima Hiroshi, Sato Yuka, Kinashi Hiroshi, Katsuno Takayuki, Maruyama Shoichi, Ito Yasuhiko

    NEPHROLOGY  2020.10 

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KAKENHI (Grants-in-Aid for Scientific Research) 20

  1. ループス腎炎における補体副経路の役割解明と治療への応用

    Grant number:21K08274  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    金 恒秀, 水野 正司, 鈴木 康弘, 石本 卓嗣, 福井 聡介

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    ループス腎炎は全身性エリテマトーデスに伴う主要な臓器障害で、近年の免疫抑制療法によっても未だ多数の患者が末期腎不全に陥っている。自然免疫の一部である補体はループス腎炎の病態に深く関わっており、新たな治療標的になると期待されている。本研究では、ループス腎炎における補体(副経路)の病態への関わりを、活性系の抑制および制御系の増強の二つのアプローチで解明し、新たな治療法の提示を行う。

  2. Elucidation of the mechanism of peritoneal dialysis-related peritoneal injury through complement pathway and establishment of novel anti-complement therapy.

    Grant number:21K08275  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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  3. 腹膜透析による補体系への影響と、腹膜傷害進展への機序の解明及びその制御

    Grant number:18K08206  2018.4 - 2021.3

    水野 正司

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    1. 現在、長期腹膜透析(PD)が、生体の腹膜に与える影響、特に補体活性系とその制御系のバランスに与える影響の検討を継続して進めている。本年度はPD透 析導後1~3年の間のPD患者の排液中の腹膜中皮初代培養細胞(HMPC)を用いて、膜補体制御因子(CRegs)の発現の変化について検討し、CRegsの中でCD46やCD59 と異なり、CD55が時間経過とともに中皮細胞への発現が増強する傾向を確認した。今年度、この一部を国際学会で発表した。さらに長期の5年以降のPD患者の排液、PD導入期の排液、腹膜炎発症による影 響を明らかにするために、現在検体の収集と解析を進めている。また、腹膜がPDにより影響を受けると考えられる個々の要因についてMet-5A細胞を用いて検討を進めている。
    2. 腹膜傷害への治療介入を期待して、現在、抗補体薬としてヒトに既に使用されているC1インヒビターを用いて真菌性腹膜炎の実験動物モデル(ラット)で明らかにし、現在国際学会への報告に向けての準備と論文化を進めている。さらに、ヒトで観察されるEPSへ至る変化を、動物モデルを用いて補体の関与について検討を進めるために海外共同研究者から補体関連蛋白の欠損マウスとノックアウトマウスの使用を開始した。一方で、腎不全動物モデル(5/6腎摘ラットモデル)を作成し、これに腹膜傷害を誘導して尿毒症の効果の検討を進めている。 3. PD排液を用いて、腹膜が実際に受けている影響を明らかにするために、これまでに行っていた補体活性化産物の一つsC5b-9の測定に加えて、補体活性化経路 の基本経路であるAlterative pathwayに注目して、ELISA系を用いて腹膜透析液排液中のC3a、プロパジンの測定を含めて、現在もデータの蓄積を進めている。
    概要1について、ほぼ計画通りに進んでいる。これまでラットから得た腹膜中皮初代細胞の検討でPD液によるCRegs発現の変化の可能性について報告しているが、 ヒト由来の中皮細胞を用いたin vitroの実験で再現できていなかった。今回、mRNAの評価までであるが、確認することができた。PD排液から得られる検体につい ては長期のフォローアップが必要なため、今後も継続して進めて行く。PDに関わる要因を細分化して行うMet-5A細胞を用いた実験についても、ほぼ予定どおり進 んでいる。 概要2について、実験動物モデルの安定性の問題で、実験の再現性確認のために時間を要している。また、補体関連蛋白の欠損マウスとノックアウトマウスの使用のための国内および国外の手続きに時間を要したため、当初の予定よりやや遅れが発生している。 概要3について、検体収集は順調に行えている。ELISAによる補体成分の測定も順次進めている。
    概要1については、 C1インヒビターによる治療実験についてR2年度中に国際学会発表と論文投稿を行う。さらに別の抗補体療法の可能性の追求を行うために、研究を継続中である。 概要2について、補体関連蛋白の欠損マウスとノックアウトマウスの輸送と、凍結胚からもどす作業が完了した。今後は速やかに実験に移っていく予定である。 概要3について、現在もPD排液検体の収集を続けているが、補体系の受ける影響について、これまでの検体を用いた測定と臨床経過との比較を行っていく。

  4. 内皮細胞Glycocalyxをターゲットとした腎疾患の新たな治療戦略の確立

    Grant number:21K08291  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    伊藤 恭彦, 石本 卓嗣, 水野 正司, 武井 佳史, 畑山 直之

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    内皮細胞Glycocalyxに着目し『内皮細胞障害をきたす腎臓病』『腹膜透析に見られる腹膜機能障害』の病態解析・改善を目指して、新規治療戦略を確立する。
    近年、内皮細胞障害を伴う『腎臓病』が増えているが、治療法は確立されていない。ex vivoシステムで糸球体内皮細胞Glycocalyx構成成分を消化しタンパク尿発現を検討、消化した成分の補充を行い標的物質を同定し、in vivoでさらに検討する。
    『腹膜機能障害』のプロジェクトでは、腹膜透過性における血管内皮細胞のintegrityの問題を提起する。腹膜血管内皮細胞Glycocalyx構成成分を消化、補充し、腹膜透過性を検討し意義を明らかにする。

  5. AKIにおける、CCR7を介したC5a経路制御機構の解明

    Grant number:19K08701  2019.4 - 2021.3

    小島 博

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    急性腎障害に補体とT細胞免疫はそれぞれ役割を果たすが、両者の相互作用については未だ不明である。最近補体が、樹状細胞(DC)の抗原提示から始まるナイーブT細胞(Th0)の分化増殖を調節することが注目され、DCとTh0細胞の会合に重要なCC-ケモカインレセプタ7(CCR7)発現が、補体活性化により誘導される可能性が報告されている。研究代表者らは補体C5aに注目してこれまで研究を進めてきたが、一方、CCR7欠損マウスで腎虚血再灌流モデル(IRI)において、野生型に比して腎障害が抑止されることを見出している。本研究において、CCR7を介したC5a経路の正の制御機構の存在を明らかにする。
    申請者らは補体に注目して、腎疾患の病態生理解明、治療法開発に取り組んできた。補体と凝固系、補体と液性免疫に密接な相互関係が存在することは知られていたが、近年、補体とT細胞免疫にも密接なクロストークがあることが明らかになってきた。本研究課題は、獲得免疫において重要な役割を果たすCCR7に注目して、補体系とT細胞免疫の相互作用の解明を目指している。CCR7は、樹状細胞(DC)とT細胞の会合や、DCの機能調節に役割を有し、T細胞免疫に重要な役割を果たす。一方で、補体H因子の存在がDCのCCR7低下をもたらした報告があり、補体活性化がCCR7発現上昇を来す可能性が示唆されるが、その分子機構や意義は不明である。
    申請者は、CCR7欠損(Ccr7-/-)、及び野生型(Ccr7+/+)マウスを用いて、aseptic急性腎障害(AKI)の代表として腎虚血再灌流(IRI)モデル、septic AKIの代表として盲腸結紮穿刺(CLP)モデルの研究を進め、CCR7が、従来報告されてきた獲得免疫だけでなく、自然免疫においても重要な役割を果たしている可能性、CCR7の有無がナチュラルキラーT (NKT)細胞の機能発現に大きな影響を与える可能性を示唆する実験結果を得た。それらの知見から、DAMPs、PAMPsから始まる免疫応答において、TLRsを介するシグナルと、補体C3レセプター(C3R)、C5レセプター(C5R)を介するシグナルが、NKT細胞で統合され、その後のT細胞免疫反応を決定づけるとの仮説を立てるに至った。
    今後は、NKT細胞上で、CCL19/21(CCR7のリガンド)-CCR7 axisとC5a-C5aR axisが統合され、その結果NKT細胞から産生されるサイトカインが、ナイーブT細胞の分化、増殖を決定するとの仮説を実証する。
    CCR7欠損、及び野生型マウスを用いて、IRIモデル、CLPモデルを作成し、結果1、結果2を得た。結果1:IRIモデルでは、CCR7欠損マウスにおいて、腎障害が軽い。結果2:CLPモデルでは、CCR7欠損マウスにおいて、腎障害が重篤であり、個体生存率も低い。
    CCR7は獲得免疫において重要な役割を果たす分子として有名であるが、IRI、CLPモデル何れにおいても、腎障害の明らかな差が、獲得免疫が作動する前の超急性期に出現した。つまり、CCR7が自然免疫においても重要な役割を果たす可能性が示唆され、NKT細胞はDAMPs、PAMPs刺激に応じて迅速に反応するので、CCR7の有無がNKT細胞の機能発現に影響していると推測された。補体系とNKT細胞はともに、ナイーブT細胞の分化、増殖に関わり、その後の獲得免疫反応を決定づけることが知られているので、NKT細胞から分泌され、ナイーブT細胞分化に関わるサイトカイン、特にインターフェロン-γ(IFNγ)に注目した。
    NKT細胞特異的リガンドであるαガラクトシルセラミド(αGalCer)を、CCR7欠損、及び野生型マウスに投与し、結果3を得た。結果3:αGalCer刺激において、CCR7欠損マウスは血清IFN-γ濃度とNKT細胞IFN-γ mRNA発現の両者が、野生型に比して、低値である。
    C5a-C5R axisがIFN-γ産生に関わることは既に報告されていたが、CCL19/21-CCR7 axisもNKT細胞のIFNγ産生に関わることが示唆された。
    CCR7とC5aRの一方と両方を刺激した場合のNKT細胞からのサイトカイン産生プロファイル、その結果としてのナイーブT細胞分化に与える影響を、in vivo、in vitroで調べる。また、aseptic AKIの代表としてのIRIモデルとseptic AKIの代表としてのCLPモデルおいて、CCR7欠損が生体にもたらす影響が、当初の予想に反して、正反対となったことから、その分子機構を解明し、AKIの病態生理の解明につなげる。
    次に、CCR7とC5aR1のダブルノックアウトマウス(Ccr7-/-C5aR-/-、以下DKO)を作成する。全身放射線照射で骨髄を死滅させたDKOマウスに、野生型(Ccr7+/+C5aR+/+)、CCR7欠損(Ccr7-/-C5aR+/+)、C5aR1欠損(Ccr7+/+C5aR-/-)、DKO(Ccr7-/-C5aR-/-)マウスからそれぞれ骨髄細胞を移植し、骨髄由来細胞のみにC5aR1、CCR7を発現する骨髄キメラマウスを作成する。これらのマウスを用いて、IRIモデルとCLPモデルを解析し、全身のC5aR1とCCR7の中で、白血球系細胞、特にNKT細胞上のC5aR1とCCR7とが重要な役割を果たしていることを示す。
    最後に、野生型マウスを用いて、IRIとCLPモデルをそれぞれ作成し、C5a阻害剤、抗CCR7抗体、両者を投与する3群とコントロール群をそれぞれ比較する。

  6. 慢性腎不全における栄養障害・筋肉量低下の病態解明と治療戦略

    Grant number:18K08207  2018.4 - 2021.3

    坂田 史子

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  7. New strategy to improve net ultrafiltration in PD and pathophysiology of peritoneal membrane dysfunction

    Grant number:18K08258  2018.4 - 2021.3

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  8. 腹膜組織解析による腹膜硬化症から被嚢性腹膜硬化症への進展機序とリスク因子の検討

    Grant number:18K08205  2018.4 - 2021.3

    鈴木 康弘

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    腹膜透析(PD)患者において被嚢性腹膜硬化症(EPS) は最も重篤な合併症であり、PD療法の普及、および長期にわたるPD継続を妨げる主要な因子である。我々は長期PD患者の腹膜組織(うちEPS発症10例を含む)を解析し、これまで腹膜障害の病変の主体として考えられていた、腹膜線維化や血管新生よりむしろ血管障害がEPS発症に強く関連する要因であることを発見し、この血管障害こそがEPS進展に重要な役割を持つのではないかという仮説を提唱した。本研究は、さらに多数のEPS手術症例から得た腹膜組織214検体を用いて、世界最大規模でEPSを病理組織学的・分子生物学的に検討し、我々の仮説を証明し、EPSの進展機序を解明することを目的とした。EPS手術症例が全国から集積するあかね会土谷総合病院と共同研究を行い、EPSによる腸閉塞症状を呈し1993年から2016年までに土谷総合病院において開腹手術、腸管癒着剥離術を施行した223症例において、手術時に採取されたEPSの腹膜組織検体283検体のうち、検体が評価に不十分なものを除いた174症例、214検体を評価対象とした。平均PD期間が128.1ヵ月、平均年齢56.0歳、初回手術が174例、再発手術が47例であった。EPS発症から手術まで平均期間は7.4ヵ月であった。我々がPLoS One 2016の報告で用いた方法にて組織学的検討を行った。酸性液(165例)と中性液(9例)の患者を比較すると、酸性液群は透析期間が有位に長く、中性液群では89%が腹膜炎罹患後のEPSであった、L/V ratioは酸性液群で有意に低値(血管障害が高度)であり、PD期間と相関していた。CD31は中性液群に多く、CD68陽性細胞数、腹膜肥厚に有意差はなかった。
    当初の計画通り、あかね会土谷総合病院において開腹手術、腸管癒着剥離術を施行した症例において、手術時に採取されたEPSの腹膜組織検体283検体のうち、検体が評価に不十分なものを除いた214検体を評価対象とし(解析した。各症例の臨床データ、PD治療の内容(ブドウ糖濃度、酸性液/中性液)、腹膜炎歴、EPS治療の内容(ステロイド治療の有無)などと組織所見とあわせて詳細に解析している。免疫組織学的評価もくわえて検討、解析を続けている。
    さらに免疫組織学的に以下の分子 (CD31、CD68、α-SMA、Podoplanin、AGE、血管成長因
    子など)の発現を解析。非EPS群との比較も行い、EPS発症に強く関与する要因を多変量解析し同定して、そのメカニズムを解明する。

  9. Establishment of new strategy targeting lymphangiogenesis in the patients with renal diseases

    Grant number:15K09287  2015.4 - 2019.3

    Yasuhiko Ito

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    Appropriate fluid balance is important for good outcomes in patients on peritoneal dialysis. The characteristic features of peritoneal injury with PD are fibrosis, inflammation and neoangiogenesis; however, these precise mechanisms remain unclear.
    We investigated the 1) roles and pathophysiology of lymphangiogenesis in PD, 2) relationship between peritoneal fibrosis and angiogenesis, and 3) roles of high salt intake in PD. We conducted the studies using animal models, in vitro studies with mesothelial cells, fibroblasts, and macrophages, and human materials including peritoneal biopsy samples and PD effluent. In animal models Adeno-soluble VEGFR-3 effectively improve the drained volume by suppression of lymphangiogenesis, suggesting thatVEGFR-3 could be the new target to improve UF. Neoangiogenesis is associated with fibrosis by TGF-β1-VEGF-A pathway in mesothelial cells and fibroblasts. High salt intake induces the inflammation leading to the increase of peritoneal transport rates.

  10. Establishment of a new treatment strategy targeting inflammation for patients with chronic renal failure

    Grant number:15K09289  2015.4 - 2018.3

    Sakata Fumiko

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    Chronic inflammation, which is often associated with high all-cause and cardiovascular mortality, is prevalent in patients with renal failure; however, the precise mechanisms remain unclear. We studied the effects and mechanisms of high salt loading on tissue and systemic inflammation in CKD mice and in cultured cells. Sodium chloride promoted tissue inflammation via osmotic stimuli in renal failure.

  11. PD-related peritonitis, especially fungal peritonitis, and peritoneal injuries associated with impairment of the complement system

    Grant number:15K09288  2015.4 - 2018.3

    Mizuno Masashi

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    Peritoneal injury is an important factor to prevent long-term peritoneal dialysis (PD), possibly following a progression of encapsulating peritoneal sclerosis (EPS) which has poor prognosis. To clarify the complement (C)-related mechanisms of development of peritoneal injuries, we have approached as an aspect of the C activation system. In the present study, we showed changes of membrane C regulators (CReg)’ expression in peritoneal mesothelium. A C activation product, we showed that sC5b-9, was useful as a surrogate maker to predict prognosis of PD-related peritonitis because peritonitis is another reason of PD withdrawal. We also developed a new peritonitis animal model to investigate mechanisms of EPS.

  12. 腹膜透析関連腹膜炎、特に真菌感染の腹膜に与える影響について、補体活性制御系の関与

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

    水野正司

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  13. Identification of novel biomarkers for early diagnosis and monitoring of cardio-renal syndrome in chronic kidney disease

    Grant number:26461222  2014.4 - 2017.3

    Suzuki Yasuhiro

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    We searched new biomarkers of cardio-renal syndrome in a mouse model with CKD. Some possible candidate substances reflecting CKD-related pathogenic changes in heart such as fibrosis were identified by metabolomics. The candidate substances were confirmed other animal models and in vitro experiments with a rat fibroblast cell line. When we also investigated serum candidate substances and echocardiography examinations in patients on peritoneal dialysis at our hospital, a significant correlation between the candidate substances and cardiac hypertrophy indicators were observed (P = 0.001, R2 = 0.25). It was suggested that some of our identified substances might play roles as new biomarkers to predict progress of cardiac fibrosis in patients with CKD.

  14. Studies of complement-related mechanisms and possibilities of anti-complement therapy for peritoneal injuries under PD therapy

    Grant number:24591227  2012.4 - 2015.3

    MASASHI Mizuno

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    Authorship:Principal investigator 

    Grant amount:\5330000 ( Direct Cost: \4100000 、 Indirect Cost:\1230000 )

    We clarified that plenty of CReg, CD46, CD55 and CD59 were expressed in mesothelial cell of human peritoneum. When we investigated whether performance of PD therapy influenced the complement system in PD patients, we got correlation between levels of sC5b-9 in PD fluid and D/P creatinine and reverse-correlation between D/P creatinine and expression of CD55 in peritoneal mesothelium in the PD patients. Between serum levels and PD fluids, C4 was well correlated but not C3. Our results suggested that PD therapy might change CD55 expression of mesothelium and influence D/P creatinine in the PD patient dependent on activation of the alternative pathway presumably.
    Using an acute peritonitis model on rat, we showed the supportive data of the possibilities of anti-complement therapies because suppression of C5a could improve the acute peritoneal injuries.

  15. New therapeutic target of lymphangiogenesis on ultrafiltration failure in PD and on chronic kidney diseases

    Grant number:24591228  2012.4 - 2015.3

    ITO yasuhiko

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    Authorship:Coinvestigator(s) 

    Appropriate fluid balance is important for good clinical outcomes and survivals in patients on peritoneal dialysis (PD). We studied the roles of lymphangiogenesis and vascular endothelial growth factor-C and -D (VEGF-C and -D), a potentially important mediator of lymphangiogenesis, in the relationship between peritoneal fibrosis and ultrafiltration failure using human dialysate effluents, human peritoneal tissues, human peritoneal mesothelial cells obtained from spent patient peritoneal dialysates, and rodent peritoneal fibrosis models. We demonstrated that lymphangiogenesis is a common feature, and is developed mainly in the diaphragm. Lymphangiogenesis is associated with fibrosis via the TGF-b-VEGF-C pathway, and VEGF-D also plays an important role in the development of lymphangiogenesis. We showed that suppression of lymphatic absorption can improve the net ultrafiltration in PD.

  16. 腹膜透析における腹膜傷害に対する補体学的機序の解明と補体制御の可能性

    2012.4 - 2014.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  17. Complement-associated analysis for improvement of prognosis in patients on long-term peritoneal dialysis

    Grant number:21591054  2009 - 2011

    MIZUNO Masashi

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    We showed that membrane complement(C) regulators(CRegs) played key roles in normal rat peritoneum and that low pH and high osmotic pressure as elements of peritoneal dialysis(PD) fluid increased peritoneal injuries under functional blocking of CRegs. We also showed that CRegs' impairments might accelerate peritoneal injuries to encapsulating peritoneal sclerosis in the zymosan induced peritonitis model in rats.

  18. Development of peritoneal sclerosis which is a serious complication in patients on peritoneal dialysis and possibilities of anti-compliment therapy as a therapy for peritoneal injuries

    Grant number:19590946  2007 - 2008

    MIZUNO Masashi

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

  19. The Role of Anaphylatoxins, C3a, C5a, in Renal Injury.

    Grant number:11671033  1999 - 2000

    MATSUO Seiichi

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    Authorship:Coinvestigator(s) 

    The following new findings were obtained by this research project.
    (A) The anaphylatoxin C5a plays an important role in glomerular thrombosis, which is one of the characteristic features of complement mediated severe glomerular injury.
    (B) A peptide, which specifically blocks C5a-receptor, effectively inhibits glomerular thrombosis in a rat model of experimental glomerulonephritis.
    (C) Recombinant human soluble thrombomodulin (RHS-TM) completely inhibits the glomerular thrombosis in this model, and this effect is partly mediated through the activation of proCPR (or TAFI) by TM-thrombin complex. Potato carboxypeptidase inhibitor (PCI), a specific inhbitor of CPR, ameliorated the antiinflammatory action of RHS-TM.Activated proCPR forms CPR and inactivates anaphylatoxins by removing the terminal arginine residues.
    (D) Anaphylatoxin receptors are expressed in the kidney and they are upregulated in human glomerulonephritis such as lupus nephritis.
    These results suggest that anaphylatoxins are the important byproducts during complement activation cascade which play important roles in the development of glomerular injury. Recently our group has cloned rat CPR.Since rat is the important animal which provides us a variety of renal injury models, we will be able to test the hypothesis by using recombinant CPR or CPR gene transfer that the control of anaphylatoxins will lessen the complement-mediated renal injury in vivo.

  20. The Role of Selections in The Formation of Glomerular Thrombi

    Grant number:10670994  1998 - 1999

    YUZAWA Yukio

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    Authorship:Coinvestigator(s) 

    The aim of this project was to investigate the role of selections and selectin ligands in the formation of glomerular thrombi, since glomerular thrombi occurs various glomerular diseases and is an important pathological parameter for the progressive renal injuries. In the present study, the role of P-selectin in the formation of glomerular thrombi and the therapeutical effects of synthetic selectin blocker were studied. In the first part of experiment using a rat model of thrombotic microangiopathy induced by injection of subnephritic dose of LPS followed by nephrotoxic globulin,the following results were obtained. (1) The formation of microthrombi completely depended on the leukocyte infiltration in glomeruli, since depletion of circulating leukocytes by cyclophosphamide completely blocked the formation on thrombi. (2) Selective expression of P-selectin in glomeruli was detected. Anti P-selectin antibody prominently blocked platelets aggregation in glomeruli at 10 minutes, and significantly blocked the infiltration of leukocytes and the formation thrombi at 6 hrs. (3) P-selectin receptor-blocking synthetic sulfatide derivative (SKK-60037) showed similar protective effects on the formation glomerular thrombi as those of anti P-selection antibody. These results indicate that P-selectin was significantly involved in the process of the formation on microthrombi, and synthetic sulfatide derivative (SKK-60037) may have potential for clinical application of progressive renal injuries. In the second part, the expression of N-acetylglucosamine-6-o-sulfotransferase mRNA was detected in the epitopes induced by this enzyme in fetal kidneys was studied. The results were as follow ; although prominent expression of N-acetylglucosamine-6-o-sulfotransferase mRNA was detected in the epithelial cells, the epitopes such as 6-sulfo LewisX or 6-sulfo sialyl Lewis X were not detected in fetal kidneys. These results indicate that the additional expression of fucosyltransferases and/or sialyltransferases might be requisite for expression of selectin ligands in the kidney.

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Social Contribution 2

  1. 第11回市民公開講座 腎臓病と共に生きる

    Role(s):Lecturer

    東海腹膜透析研究会  2018.7

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    Audience: General

    Type:Lecture

    「腎不全の治療法(PD/HD/移植)」の講演

  2. 第8回腎臓から考える健康ライフセミナー~はじめてみよう!腎臓を守るための身近な生活習慣からの見直し

    Role(s):Lecturer

    2018.3

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    Audience: Civic organization