Updated on 2021/04/09

写真a

 
SUZUKI, Hiromi
 
Organization
Research Institute of Environmental Medicine Division of Stress Adaptation and Protection Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor
Contact information
メールアドレス
External link

Degree 1

  1. 医学博士 ( 藤田保健衛生大学短期大学 ) 

Research Interests 3

  1. Imaging

  2. DDS

  3. microglia

Research Areas 1

  1. Others / Others  / 神経化学 神経病理学

Current Research Project and SDGs 9

  1. LMD-LC-MSによる脳内の薬物動態と神経伝達物質変化の細胞毎イメージング

  2. ミクログリア機能を反映するPETイメージング

  3. MALDI MSイメージングでの生体高分子の検出やLC-MS/MS分析でも質量イメージングを可能にする技術の確立

  4. 脳特異的ドラッグデリバリシステムの構築、微小血管解析システムを用いた脳・神経系ヘの細胞浸潤のイメージング

  5. 脳標的化ペプチドを用いた脳疾患のPET診断用システム開発

  6. 脳病態における活性化ミクログリアの毒性転換のメカニズム

  7. 脳標的化分子の単離

  8. 脳イメージングのためのリガンド輸送ツール開発

  9. 脳への選択的物質輸送システムの開発

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Research History 9

  1. 助教

    2009.3

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    Country:Japan

  2. 株式会社ティッシュターゲティングジャパン 研究開発部 主任研究員

    2005.3

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    Country:Japan

  3. Department of Physiology, OTAGO univ.

    2003.5 - 2003.6

  4. 名古屋大学環境医学研究所 脳機能分野 客員研究者

    2003.4 - 2009.2

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    Country:Japan

  5. 藤田保健衛生大学総合医科学研究所 難病治療共同研究部門 助手

    2003.4 - 2005.2

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    Country:Japan

  6. 放射線医学総合研究所 客員協力研究員

    2003.4

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    Country:Japan

  7. 科学技術振興事業団さきがけ 研究補助員

    2001.9 - 2002.2

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    Country:Japan

  8. 藤田保健衛生大学総合医科学研究所難病治療共同研究部門 研究員

    2001.4 - 2003.3

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    Country:Japan

  9. 藤田学園保健衛生大学医学部脳神経外科 研究員

    1994.4 - 2001.3

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    Country:Japan

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Education 2

  1. Fujita Health University

    - 2003.3

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    Country: Japan

  2. Fujita Health University

    1986.4 - 1991.3

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    Country: Japan

Professional Memberships 4

  1. 日本分子イメージング学会

  2. 日本バイオイメージング学会

  3. 日本神経化学会

  4. The Molecular Biology Society of Japan

 

Papers 58

  1. LC-MS/MS imaging with thermal film-based laser microdissection Reviewed International coauthorship

    Oya Michiko, Suzuki Hiromi, Anas Andrea Roxanne J., Oishi Koichi, Ono Kenji, Yamaguchi Shun, Eguchi Megumi, Sawada Makoto

    ANALYTICAL AND BIOANALYTICAL CHEMISTRY   Vol. 410 ( 2 ) page: 491-499   2018.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00216-017-0739-2

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  2. Peripheral benzodiazepine receptor/18 kDa translocator protein positron emission tomography imaging in a rat model of acute brain injury Reviewed International coauthorship

    Nomura M, Toyama H, Suzuki H, Yamada T, Hatano K, Alan A Wilson, Ito K, Sawada M

    Ann Null Med.   Vol. 35 ( 1 ) page: 8 - 16   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1007/s12149-020-01530-2

  3. Visualization of Arc promoter-driven neuronal activity by magnetic resonance imaging Reviewed

    Wu Qi, Ono Kenji, Suzuki Hiromi, Eguchi Megumi, Yamaguchi Shun, Sawada Makoto

    NEUROSCIENCE LETTERS   Vol. 666   page: 92-97   2018.2

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    DOI: 10.1016/j.neulet.2017.12.041

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  4. Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin. Invited Reviewed

    Wang L, Li M, Lin Y, Du S, Liu Z, Ju J, Suzuki H, Sawada M, Umezawa K

    The Journal of antibiotics   Vol. 73 ( 9 ) page: 622 - 629   2020.9

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    Publishing type:Research paper (scientific journal)   Publisher:Journal of Antibiotics  

    DOI: 10.1038/s41429-020-0302-9

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  5. Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects Invited Reviewed

    Mitsuhiro Kawakubo, Miyako Tanaka, Kozue Ochi, Akiko Watanabe, Marie Saka-Tanaka, Yohei Kanamori, Naoki Yoshioka, Satoko Yamashita, Moritaka Goto, Michiko Itoh, Ibuki Shirakawa, Sayaka Kanai, Hiromi Suzuki, Makoto Sawada, Ayaka Ito, Masatoshi Ishigami, Mitsuhiro Fujishiro, Hiroshi Arima, Yoshihiro Ogawa, Takayoshi Suganami

    Science Report   Vol. 10 ( 1 ) page: 983   2020.1

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    Nonalcoholic steatohepatitis (NASH) is a hepatic phenotype of the metabolic syndrome, and increases the risk of cirrhosis and hepatocellular carcinoma (HCC). Although increasing evidence points to the therapeutic implications of certain types of anti-diabetic agents in NASH, it remains to be elucidated whether their effects on NASH are independent of their effects on diabetes. Genetically obese melanocortin 4 receptor-deficient (MC4R-KO) mice fed Western diet are a murine model that sequentially develops hepatic steatosis, NASH, and HCC in the presence of obesity and insulin resistance. In this study, we investigated the effect of the dipeptidyl peptidase-4 (DPP-4) inhibitor anagliptin on NASH and HCC development in MC4R-KO mice. Anagliptin treatment effectively prevented inflammation, fibrosis, and carcinogenesis in the liver of MC4R-KO mice. Interestingly, anagliptin only marginally affected body weight, systemic glucose and lipid metabolism, and hepatic steatosis. Histological data and gene expression analysis suggest that anagliptin treatment targets macrophage activation in the liver during the progression from simple steatosis to NASH. As a molecular mechanism underlying anagliptin action, we showed that glucagon-like peptide-1 suppressed proinflammatory and profibrotic phenotypes of macrophages in vitro. This study highlights the glucose metabolism-independent effects of anagliptin on NASH and HCC development.

    DOI: 10.1038/s41598-020-57935-6

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  6. Novel Oxindole-Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection Reviewed

    Yoko Hirata, Yuki Ito, Madoka Takashima, Kazuya Yagyu, Kentaro Oh-Hashi, Hiromi Suzuki, Kenji Ono, Kyoji Furuta, Makoto Sawada

    ACS Chem Neurosci .   Vol. 11 ( 1 ) page: 76-85   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    Oxidative stress plays an important role in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. The oxindole compound GIF-2165X-G1 is a hybrid molecule composed of the oxindole skeleton of the neuroprotective compound GIF-0726-r and the polyphenolic skeleton of the antioxidant curcumin. We previously reported that novel oxindole derivatives such as GIF-0726-r and GIF-2165X-G1 prevent endogenous oxidative stress-induced cell death in mouse hippocampal HT22 cells. In this study, we present a detailed investigation of the effect of GIF-2165X-G1 on endogenous oxidative stress in HT22 cells in comparison with GIF-0726-r and curcumin. GIF-2165X-G1 exhibited more potent neuroprotective activity than GIF-0726-r or curcumin and had less cytotoxicity than that observed with curcumin. Both GIF-0726-r and GIF-2165X-G1 were found to have ferrous ion chelating activity similar to that exhibited by curcumin. GIF-2165 X-G1 and curcumin induced comparable antioxidant response element transcriptional activity. Although the induction of heme oxygenase-1, an antioxidant response element-regulated gene product, was much stronger in curcumin-treated cells than in GIF-2165X-G1-treated cells, it turned out that the induction of heme oxygenase-1 is dispensable for neuroprotection. These results demonstrate that the introduction of the polyphenol skeleton of curcumin to the oxindole GIF-0726-r improves neuroprotective features. Furthermore, intrastriatal injection of GIF-2165X-G1 alleviated apomorphine-induced rotation and prevented dopaminergic neuronal loss in a 6-hydroxydopamine mouse model of Parkinson's diseases. Collectively, our novel findings indicate that the novel oxindole compound GIF-2165X-G1 serves to delay the progression of Parkinson's disease by suppressing oxidative stress.

    DOI: 10.1021/acschemneuro.9b00619.

  7. Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration.

    Takatani Y, Ono K, Suzuki H, Inaba M, Sawada M, Matsuda N

    Laboratory investigation; a journal of technical methods and pathology   Vol. 98 ( 5 ) page: 629-639   2018.5

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    DOI: 10.1038/s41374-018-0021-z

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  8. Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells.

      Vol. 135   page: 242-252   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuropharm.2018.03.015

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  9. Optogenetic control of cell differentiation in channelrhodopsin-2-expressing OS3, a bipotential glial progenitor cell line

    Ono K, Suzuki H, Yamamoto R, Sahashi H, Takido Y, Sawada M.

    Neurochemistry International   Vol. 104   page: 49-63   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuint.2016.12.022.

  10. Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [ 11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [ 11C](R)-PK11195. Invited Reviewed

    Hatano K, Sekimata K, Yamada T, Abe J, Ito K, Ogawa M, Magata Y, Toyohara J, Ishiwata K, Biggio G, Serra M, Laquintana V, Denora N, Latrofa A, Trapani G, Liso G, Suzuki H, Sawada M, Nomura M, Toyama H.

    Annals of nuclear medicine   Vol. 29 ( 4 ) page: 325 - 35   2015.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12149-015-0948-8

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  11. Protective effect of INI-0602, a gap junction inhibitor, on dopaminergic neurodegeneration of mice with unilateral 6-hydroxydopamine injection

    SUZUKI Hiromi,ONO Kenji,SAWADA Makoto

    Journal of Neural Transmission   Vol. 121 ( 11 ) page: 1349-1355   2014.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00702-014-1209-z.

  12. Glutamate release from astrocyte cell-line GL261 via alterations in the intracellular ion environment Invited Reviewed

    ONO K, SUZUKI H, HIGA M, TABATA K, SAWADA M

    Journal of Neural Transmission   Vol. 121 ( 3 ) page: 245 - 257   2014.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00702-013-1096-8

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  13. New fluorescent probes targeting the mitochondrial-located translocator protein 18 kDa (TSPO) as activated microglia imaging agents. Reviewed

    DENORA N, LAQUINTANA V, TRAPANI A, SUZUKI H, SAWADA M, TRAPANI G

    Pharmaceutical Research   Vol. 28 ( 11 ) page: 2820-2832   2011.11

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  14. Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. Reviewed

    IWAMA S, SUGIMURA Y, SUZUKI H, SUZUKI H, MURASE T, OZAKI N, NAGASAKI H, ARIMA H, MURATA Y, SAWADA M, OISO Y

    Glia   Vol. 59 ( 3 ) page: 452-462   2011.3

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  15. Pathway analysis of single-microglia gene-expression profiles reveals the new molecular targets of minocycline treatment Invited Reviewed

    Suzuki Haruyuki, Sugimura Yoshihisa, Iwama Shintaro, Suzuki Hiromi, Takagi Hiroshi, Kiyota Atsushi, Fukuoka Kazuki, Sawada Makoto, Oiso Yutaka

    NEUROSCIENCE RESEARCH   Vol. 71   page: E223 - E223   2011

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2011.07.969

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  16. Visualization of iNOS gene expression from activated cells in magnetic resonance imaging Invited Reviewed

    Ono Kenji, Tabata Kaori, Suzuki Hiromi, Sawada Makoto

    NEUROSCIENCE RESEARCH   Vol. 71   page: E96 - E96   2011

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2011.07.413

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  17. Minocycline Prevents Osmotic Demyelination Syndrome by Inhibiting the Activation of Microglia Invited Reviewed

    Suzuki Haruyuki, Sugimura Yoshihisa, Iwama Shintaro, Suzuki Hiromi, Nobuaki Ozaki, Nagasaki Hiroshi, Arima Hiroshi, Sawada Makoto, Oiso Yutaka

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   Vol. 21 ( 12 ) page: 2090 - 2098   2010.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1681/ASN.2010040438

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  18. Electrosprayed Synthesis of Red-Blood-Cell-Like Particles with Dual Modality for Magnetic Resonance and Fluorescence Imaging Invited Reviewed

    Hayashi Koichiro, Ono Kenji, Suzuki Hiromi, Sawada Makoto, Moriya Makoto, Sakamoto Wataru, Yogo Toshinobu

    SMALL   Vol. 6 ( 21 ) page: 2384 - 2391   2010.11

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    DOI: 10.1002/smll.201000399

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  19. High-frequency, magnetic-field-responsive drug release from magnetic nanoparticle/organic hybrid based on hyperthermic effect.

    HAYASHI K, ONO K, SUZUKI H, SAWADA M, MORIYA M, SAKAMOTO W, YOGO T

    ACS applied materials & interfaces   Vol. 2 ( 7 ) page: 1903-1911   2010.7

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  20. One-Pot Biofunctionalization of Magnetic Nanoparticles via Thiol-Ene Click Reaction for Magnetic Hyperthermia and Magnetic Resonance Imaging Invited Reviewed

    Hayashi Koichiro, Ono Kenji, Suzuki Hiromi, Sawada Makoto, Moriya Makoto, Sakamoto Wataru, Yogo Toshinobu

    CHEMISTRY OF MATERIALS   Vol. 22 ( 12 ) page: 3768 - 3772   2010.6

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/cm100810g

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  21. Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model Invited Reviewed

    Ono Kenji, Suzuki Hiromi, Sawada Makoto

    NEUROSCIENCE LETTERS   Vol. 473 ( 2 ) page: 146 - 150   2010.4

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neulet.2010.02.041

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  22. Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [^<11>C]PK11195 in rats Invited Reviewed

    ITO Fumitaka, TOYAMA Hiroshi, KUDO Gen, SUZUKI Hiromi, HATANO Kentaro, ICHISE Masanori, KATADA Kazuhiro, ITO Kengo, SAWADA Makoto

    Annals of nuclear medicine   Vol. 24 ( 3 ) page: 163 - 169   2010.4

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  23. Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model Reviewed

    ONO Kenji, SUZUKI Hiromi, SAWADA Makoto

    Neuroscience Letters   Vol. 473 ( 2 ) page: 146-150   2010.4

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  24. Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [(11)C]PK11195 in rats. Invited Reviewed

    Ito F, Toyama H, Kudo G, Suzuki H, Hatano K, Ichise M, Katada K, Ito K, Sawada M

    Annals of nuclear medicine   Vol. 24 ( 3 ) page: 163 - 9   2010.4

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12149-009-0339-0

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  25. Neuroprotective and Neurotoxic Phenotypes of Activated Microglia in Neonatal Mice with Respective MPTP- and Ethanol-Induced Brain Injury. Reviewed

    Sawada H, Suzuki H, Nagatsu T, Sawada M.

    Neuro-degenerative Diseases   Vol. 7 ( 1-3 ) page: 64-67   2010.2

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  26. Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. Reviewed

    SUZUKI H, SUGIMURA Y, IWAMA S, SUZUKI H, OZAKI N, NAGASAKI H, ARIMA H, SAWADA M, OISO Y.

    Journal of the American Society of Nephrology   Vol. 21 ( 12 ) page: 2090-2098   2010

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  27. Control of activation in ChR2-expressing astrocytes by blue light exposure Invited Reviewed

    Ono Kenji, Higa Madoka, Tabata Kaori, Suzuki Hiromi, Sawada Makoto

    NEUROSCIENCE RESEARCH   Vol. 68   page: E57 - E57   2010

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2010.07.020

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  28. Gene expression profiling of microglia from the demyelinative lesions in osmotic demyelination syndrome rats Invited Reviewed

    Sugimura Yoshihisa, Suzuki Haruyuki, Iwama Shintaro, Suzuki Hiromi, Kiyota Atsushi, Sawada Makoto, Oiso Yutaka

    NEUROSCIENCE RESEARCH   Vol. 68   page: E199 - E199   2010

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2010.07.2453

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  29. Isolation of Microglia Subpopulations Invited Reviewed

    Sawada Makoto, Suzuki Hiromi

    PROTCOLS FOR NEURAL CELL CULTURE, FOURTH EDITION     page: 231 - 239   2010

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/978-1-60761-292-6_13

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  30. Neuroprotective and neurotoxic phenotypes of activated microglia in neonatal mice with respective MPTP- and ethanol-induced brain injury. Invited Reviewed

    Sawada H, Suzuki H, Nagatsu T, Sawada M

    Neuro-degenerative diseases   Vol. 7 ( 1-3 ) page: 64 - 7   2010

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000285508

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  31. Protective roles of brain-migrated immature bone marrow cells against NO-dependent neurotoxicity in a brain injury model Invited Reviewed

    Ono Kenji, Yamamoto Naho, Suzuki Hiromi, Sawada Makoto

    NEUROSCIENCE RESEARCH   Vol. 65   page: S43 - S43   2009

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2009.09.055

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  32. Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state

    MATSUMURA T, SAKAI A, NAGANO M, SAWADA M, SUZUKI H, UMINO M, SUZUKI H

    British Journal of Pharmacology   Vol. 155 ( 5 ) page: 767-774   2008.11

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  33. Blockade of microglial glutamate release protects against ischemic brain injury Invited Reviewed

    Takeuchi Hideyuki, Jin Shijie, Suzuki Hiromi, Doi Yukiko, Liang Jianfeng, Kawanokuchi Jun, Mizuno Tetsuya, Sawada Makoto, Suzumura Akio

    EXPERIMENTAL NEUROLOGY   Vol. 214 ( 1 ) page: 144 - 146   2008.11

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    DOI: 10.1016/j.expneurol.2008.08.001

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  34. In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand : [^<11>C]PK-11195 and animal PET following ethanol injury in rat striatum Invited Reviewed

    TOYAMA Hiroshi, HATANO Kentaro, SUZUKI Hiromi, ICHISE Masanori, MOMOSAKI Sotaro, KUDO Gen, ITO Fumitaka, KATO Takashi, YAMAGUCHI Hiroshi, KATADA Kazuhiro, SAWADA Makoto, ITO Kengo

    Annals of nuclear medicine   Vol. 22 ( 5 ) page: 417 - 424   2008.6

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  35. Enhancement of glioma formation and growth by brain-migrated immature bone marrow cells Invited Reviewed

    Ono Kenji, Furukawa Taiki, Suzuki Hiromi, Sato Emi, Sawada Makoto

    NEUROSCIENCE RESEARCH   Vol. 61   page: S276 - S276   2008

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  36. N-benzyl-2-(6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N-(6-(7-nitrobenzo[c][1,2,5]oxadiazol-4-ylamino)hexyl)acetamide as a new fluorescent probe for peripheral benzodiazepine receptor and microglial cell visualization. Invited Reviewed

    Laquintana V, Denora N, Lopedota A, Suzuki H, Sawada M, Serra M, Biggio G, Latrofa A, Trapani G, Liso G

    Bioconjugate chemistry   Vol. 18 ( 5 ) page: 1397 - 407   2007.9

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/bc060393c

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  37. Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Invited Reviewed

    Sawada H, Hishida R, Hirata Y, Ono K, Suzuki H, Muramatsu S, Nakano I, Nagatsu T, Sawada M

    Journal of neuroscience research   Vol. 85 ( 8 ) page: 1752 - 61   2007.6

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jnr.21241

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  38. Modulation of Reelin signaling by Cyclin-dependent kinase 5. Invited Reviewed

    Ohshima T, Suzuki H, Morimura T, Ogawa M, Mikoshiba K

    Brain research   Vol. 1140   page: 84 - 95   2007.4

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.brainres.2006.01.121

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  39. Neuroprotective effect of exogenous microglia in global brain ischemia. Invited Reviewed

    Imai F, Suzuki H, Oda J, Ninomiya T, Ono K, Sano H, Sawada M

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   Vol. 27 ( 3 ) page: 488 - 500   2007.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.jcbfm.9600362

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  40. [Targeting and imaging of brain-specific cell migration]. Invited Reviewed

    Sawada M, Ono K, Suzuki H

    Nihon rinsho. Japanese journal of clinical medicine   Vol. 65 ( 2 ) page: 213 - 8   2007.2

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  41. Mutation induction in cultured human cells after low-dose and low-dose-rate gamma-ray irradiation: detection by LOH analysis. Invited Reviewed

    Umebayashi Y, Honma M, Suzuki M, Suzuki H, Shimazu T, Ishioka N, Iwaki M, Yatagai F

    Journal of radiation research   Vol. 48 ( 1 ) page: 7 - 11   2007.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1269/jrr.06054

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  42. P2-16 新生時由来ミクログリアの活性化がパーキンソン病モデルマウスの黒質ドーパミンニューロンに対して神経保護的にはたらく可能性(脳神経,一般演題,第48回日本組織細胞化学会総会(第8回日中合同組織細胞化学セミナー) 第39回日本臨床分子形態学会総会 合同学術集会) Invited Reviewed

    澤田 浩秀, 菱田 良平, 平田 洋子, 小野 健治, 鈴木 弘美, 村松 慎一, 中野 今治, 永津 俊治, 澤田 誠

    日本組織細胞化学会総会プログラムおよび抄録集   ( 48 )   2007

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  43. The intra-arterial injection of microglia protects hippocampal CA1 neurons against global ischemia-induced functional deficits in rats

    HAYASHI Y, TOMIMATSU Y, SUZUKI H, YAMADA J, WU Z, YAO H, KAGAMIISI Y, TAKEISHI N, SAWADA M, NAKANISHI H

    Neuroscience   Vol. 142 ( 1 ) page: 87-96   2006.9

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  44. Modulations of muscle protein metabolism by branched-chain amino acids in normal and muscle-atrophying rats. Invited Reviewed

    Kobayashi H, Kato H, Hirabayashi Y, Murakami H, Suzuki H

    The Journal of nutrition   Vol. 136 ( 1 Suppl ) page: 234S - 6S   2006.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jn/136.1.234S

    PubMed

  45. A lentiviral expression system demonstrates that L*protein of Theiler's murine encephalomyelitis virus(TMEV) is essential for virus growth in a murine macrophage-like cell line.

    HIMEDA T, OHARA Y, ASAKURA K, KONTANI Y, MURAKAMI M, SUZUKI H, SAWADA M

    Virus Research   Vol. 108 ( 1-2 ) page: 23-28   2005.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  46. Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains.

    IMAMURA K, HISHIKAWA N, ONO K,SUZUKI H, SAWADA M, NAGATSU T, YOSHIDA M, HASHIZUME Y

    Acta Neuropathologica   Vol. 109 ( 2 ) page: 141-150   2005.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  47. Murine lymph node-derived stromal cells effectively support survival but induce no activation/proliferation of peripheral resting T cells in vitro Invited Reviewed

    Zhou YW, Aritake S, Endharti AT, Wu JH, Hayakawa A, Nakashima I, Suzuki H

    IMMUNOLOGY   Vol. 109 ( 4 ) page: 496 - 503   2003.8

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    Publishing type:Research paper (scientific journal)  

    Web of Science

  48. Preservation of hematopoietic properties in transplanted bone marrow cells in the brain. Invited Reviewed

    Ono K, Yoshihara K, Suzuki H, Tanaka KF, Takii T, Onozaki K, Sawada M

    Journal of neuroscience research   Vol. 72 ( 4 ) page: 503 - 7   2003.5

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jnr.10588

    PubMed

  49. Existence of functional beta1- and beta2-adrenergic receptors on microglia. Invited Reviewed

    Tanaka KF, Kashima H, Suzuki H, Ono K, Sawada M

    Journal of neuroscience research   Vol. 70 ( 2 ) page: 232 - 7   2002.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jnr.10399

    PubMed

  50. Modes of activation of mitogen-activated protein kinases and their roles in cepharanthine-induced apoptosis in human leukemia cells Invited Reviewed

    Wu JH, Suzuki H, Akhand AA, Zhou YW, Hossain K, Nakashima I

    CELLULAR SIGNALLING   Vol. 14 ( 6 ) page: 509 - 515   2002.6

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    Publishing type:Research paper (scientific journal)  

    Web of Science

  51. Preservation of neurotophin expression in microglia that migrate into the gerbil's brain across the blood-brain barrier.

    SUZUKI H, IMAI F, KANNO T, SAWADA M

    Neuroscience Letters   Vol. 312 ( 2 ) page: 95-98   2001.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  52. Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation Invited Reviewed

    Takeda K, Kato M, Wu JH, Iwashita T, Suzuki H, Takahashi M, Nakashima I

    ANTIOXIDANTS & REDOX SIGNALING   Vol. 3 ( 3 ) page: 473 - 482   2001.6

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    Publishing type:Research paper (scientific journal)  

    Web of Science

  53. Molecular architecture via coordination: quasi-octahedral macrocycles of rhodium and iridium bearing a pentamethylcyclopentadienyl group Invited Reviewed

    Suzuki H, Tajima N, Tatsumi K, Yamamoto Y

    CHEMICAL COMMUNICATIONS   ( 18 ) page: 1801 - 1802   2000

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    Publishing type:Research paper (scientific journal)  

    Web of Science

  54. Molecular Mechanism of Activation and Superactivation of Ret Tyrosine Kinases by Ultraviolet Light Irradiation Invited Reviewed

    Kato Masashi, Iwashita Toshihide, Akhand Anwarul A., Liu Wei, Takeda Kozue, Takeuchi Kei, Yoshihara Motoi, Hossain Khaled, Wu Jianghong, Du Jun, Oh Chanho, Kawamoto Yoshiyuki, Suzuki Haruhiko, Takahashi Masahide, Nakashima Izumi

    ANTIOXIDANTS & REDOX SIGNALING   Vol. 2 ( 4 ) page: 841 - 850   2000

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    Publishing type:Research paper (scientific journal)  

    Web of Science

  55. Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo Invited Reviewed

    Suzuki H, Zhou YW, Kato M, Mak TW, Nakashima I

    JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 190 ( 11 ) page: 1561 - 1571   1999.12

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    Publishing type:Research paper (scientific journal)  

    Web of Science

  56. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions.

    IMAI F, SAWADA M, SUZUKI H, ZLOKOVIC BV, KOJIMA J, KUNO S, NAGATSU T, NITATORI T, UCHIYAMA Y, KANNNO T

    Neuroscience Letters   Vol. 272 ( 2 ) page: 127-130   1999.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  57. Brain-specific gene expression by immortalized microglia cell-mediated gene transfer in the mammalian brain

    SAWADA M, IMAI F, SUZUKI H. HAYAKAWA M, KANNO T, NAGATSU T

    FEBS Letters   Vol. 433 ( 1-2 ) page: 37-40   1998.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  58. Migration activity of microglia and macrophages into rat brain.

    IMAI F, SAWADA M, SUZUKI H, KIYA N, HAYAKAWA M,NAGATSU T, MARUNOUCHI T, KANNO T

    Neuroscience Letters   Vol. 237 ( 1 ) page: 49-52   1997.11

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Books 7

  1. PET/CT for Inflammatory Diseases: Basic Sciences, Typical Cases, and Review

    Hiromi Suzuki, Makoto Sawada( Role: Contributor ,  Role of Microglia in Neuroinflammation)

    Springer  2020.2  ( ISBN:978-981-15-0810-3

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    Total pages:234   Language:English Book type:Textbook, survey, introduction

    At present, common diseases of CNS were often chronic and progressive which could affect the patient's quality of life seriously. But the pathogenesis for most of them had not been fully understood and was no effective pre- vention or treatment. Certain pathological injury could cause cellular inflammatory response. Microglia, the first activated effector cells, played an important role in the immune defense process. Microglia had a two-way effect. On the one hand, activated microglia phagocytosed damaged cell debris and removed antigenic substances, and could release cyto- toxic factors which would aggravate the injury of neuron. On the other hand, activated microglia may accumulate around damaged neurons and might induce neurotrophin-dependent protective activity. Therefore, to study the mechanism of microglia in the diseases of CNS and limit their effects on neuronal injury may help to retard the procession of some chronic disease and enhance the therapeutic effect of acute CNS diseases. Microglia are expected to become a new tar- get for the treatment of neurodegenerative diseases and cen- tral nervous system diseases.

  2. アルツハイマー病 発症メカニズムと新規診断法・創薬・治療開発

    澤田 誠, 鈴木弘美( Role: Joint author)

    株式会社エヌ・ティ・エス  2018.8  ( ISBN:978-4-86043-578-3

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    Total pages:460   Language:Japanese Book type:Textbook, survey, introduction

  3. 脳卒中病態学のススメ・脳内マクロファージとミクログリア

    澤田 誠, 鈴木弘美( Role: Joint author)

    南山堂  2018.2  ( ISBN:978--4-525-24851-2

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    Language:Japanese

  4. Etiology and Pathophysiology of Parkinson's Disease: Role of microglia in inflammatory process, in Parkinson's disease

    Sawada H, Suzuki H, Ono K, Imamaura K, Nagatsu T, Sawada M( Role: Joint author)

    InTech  2011.10  ( ISBN:978-953-307-462-7

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    Language:English

  5. 遺伝子医学MOOK: 小動物PETによるラットパーキンソン病モデルの神経傷害性と治療効果判定

    外山 宏、籏野健太郎、鈴木弘美( Role: Joint author)

    メディカルドゥ  2010.10 

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    Language:Japanese

  6. 脳循環代謝: 小動物における定量的画像解析

    外山宏、籏野健太郎、鈴木弘美、工藤元、野村昌彦、山田貴史、木村裕一、市瀬正則、澤田誠( Role: Joint author)

    日本脳循環代謝学会  2010.7 

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    Language:Japanese

  7. Protocols for Neural Cell Culture・Isolation of microglia subpopulations

    SAWADA Makoto, SUZUKI Hiromi( Role: Joint author)

    Humana Press  2009 

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    Language:English

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Presentations 60

  1. オリゴデンドロサイトへ分化誘導したグリア前駆細胞株から放出されるエクソソームの性質

    小野健治, 大橋和哉, 鈴木弘美, 澤田 誠

    第43回日本神経科学大会  2020.8.1  大阪大学 北澤茂

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    Event date: 2020.7 - 2020.8

    Language:English   Presentation type:Poster presentation  

    Venue:神戸   Country:Japan  

  2. ホットメルトレーザーマイクロダイセクションおよび並列LCを用いた高速LC-MSイメージングシステムの開発

    古賀裕介, 洪暎淳, 松本龍太, 鈴木弘美, 小野健治, 前田裕樹, 小河潔, 澤田 誠

    第68回日本質量分析総合討論会  2020.5.11  一般社団法人 日本質量分析学会 川﨑 英也

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    Event date: 2020.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪   Country:Japan  

  3. 神経変性疾患に関連する薬剤と神経伝達物質およびL-アミノ酸のLC-MS/MS条件の最適化

    名城大学薬学部環境科学研究室発表会 

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名城大学薬学部   Country:Japan  

  4. Preliminary study on LC-MS/MS analysis of related drugs, nuerotransmitters, translocator protein (TSPO) ligands in brain/liver homogenates by API4000 in a single HILIC system

    Andrea Roxanne J. ANAS, Morosaki Junko, Torii Yuna, Oya Michiko, Suzuki Hiromi, Imanishi Susumu Y, Sawada Makoto, Harada Ken-ichi

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    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  5. LMD-LC-MSによる脳内の薬物動態と神経伝達物質変化の細胞毎イメージング

    鈴木弘美、Andrea Anas, 小野健治、大石幸一、澤田 誠

    第41回日本分子生物学会年会 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:パシフィコ横浜(横浜市西区みなとみらい)   Country:Japan  

  6. LC-MS/MS analysis of neurotransmitters,translocator protein (TSPO) ligands and related drugs in a single hilic system International conference

    Andrea Roxanne J. ANAS, Morosaki Junko, Torii Yuna, Oya Michiko, SuzukiHiromi, Imanishi Susumu Y, Sawada Makoto, Harada Ken-ichi

    45th Annual convention of the Philipine Society of Biochemistry and Molecular Biology 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Grand Xing Imperial Hotel(Iloilo city, Philippine)   Country:Philippines  

  7. LC-MS/MSを用いた神経伝達物質、TSPOおよび関連薬物の同時定量

    Andrea Roxanne J. ANAS, 森崎潤子, 鳥居優奈, 大矢倫子, 鈴木弘美, 今西 進, 澤田 誠, 原田健一

    第43回日本医用マススペクトル学会年会 

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    Event date: 2018.9

    Language:English   Presentation type:Poster presentation  

    Venue:北海道大学学術交流会館   Country:Japan  

  8. Liquid chromatography optimization of pilocarpine, amino acids, neurotransmitters and related drug by API4000 based on log D

    Andrea Roxanne Jocsing ANAS, 森崎 潤子, 大矢 倫子, 鈴木 弘美, 澤田 誠, 原田 健一

    日本薬学会第138年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  9. MALDI MSイメージングでの生体高分子の検出やLC-MS/MS分析でも質量イメージングを可能にする技術の確立

    鈴木弘美

    神経変性疾患のPETイメージング プロジェクトミーティング 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金山研修センター   Country:Japan  

  10. MALDI MSイメージングでの生体高分子の検出やLC-MS/MS分析でも質量イメージングを可能にする技術の確立

    鈴木弘美、Andrea Anas,大矢倫子、小野健治、大石幸一、澤田誠

    第40回日本分子生物学会年会(ConBio2017) 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸国際展示場   Country:Japan  

  11. 光感受性陽イオンチャネルChR2を介したNG2陽性グリア前駆細胞のオリゴデンドロサイトへの分化

    小野健治、川嶋裕人、鈴木弘美、澤田誠

    第90回日本生化学会大会(ConBio2017) 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸国際展示場   Country:Japan  

  12. LC-MS/MS for neural catecholamines, drugs and TSPO ligands by API4000 International conference

    Anas ARJ, Suzuki H, Imanishi SY, Harada K-1, Sawada M

    RACI(Royal Australian Chemical Institute) Centenary Cogress 

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    Event date: 2017.7

    Language:English   Presentation type:Poster presentation  

    Venue:Melbourne,Australia   Country:Australia  

  13. 光感受性イオンチャネルChRGRを介したミクログリアの機能制御

    小野健治、鈴木弘美,今野歩、石塚徹、平井宏和、八尾寛、澤田誠

    第40回日本神経科学大会 

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    Event date: 2017.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  14. LC-MS Imagingによる脳内での薬物動態と神経伝達物質変化の同時解析

    大矢倫子、鈴木弘美、大石幸一、小野健治、澤田誠

    第2回医薬系3部局交流シンポジウム 環境医学研究所・群馬大学生体調節研究所合同シンポジウム 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋大学 野依記念学術交流館   Country:Japan  

  15. LC-MS Imagingによる脳内での薬物動態と神経伝達物質変化の同時解析

    大矢倫子、鈴木弘美、大石幸一、小野健治、澤田誠

    第65回質量分析総合討論会 

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    Event date: 2017.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:つくば国際会議場   Country:Japan  

  16. Optimization for Neural Catecholamines, its metabolites and Related Drugs in a Sigle LC-MS/MS Analysis using API4000

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  17. Optimization for Neural Catecholamines, its metabolites and Related Drugs in a Sigle LC-MS/MS Analysis using API4000

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  18. ミクログリアのサブタイプイメージング

    鈴木弘美

    神経変性疾患のPETイメージングに関する共同研究を検討するミーティング 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国立長寿研究センター   Country:Japan  

  19. 光感受性イオンチャネルChRGRを介したミクログリアの機能調節に関する解析

    小野健治、鈴木弘美、今野 歩、平井宏和、八尾 寛、澤田 誠

    第89回日本生化学会大会in 仙台 

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:仙台国際センター   Country:Japan  

  20. グリア前駆細胞株OS3細胞のチャネルロドプシン2を介したオリゴデンドロサイトの分化

    小野健治、山本龍生、佐橋秀紀、滝戸悠平、呉起、鈴木弘美、澤田 誠

    第39回日本神経科学会 

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    Event date: 2016.7

    Language:English   Presentation type:Poster presentation  

    Venue:パシフィコ横浜   Country:Japan  

  21. 3D質量分析イメージングを実現する前処理技術

    澤田誠、鈴木弘美、小野健治、大石幸一

    第64回日本質量分析総合討論会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  22. 光刺激したグリア前駆細胞株OS3ChR2細胞注入による脱髄疾患モデルマウスの運動機能改善

    小野健治、滝戸悠平、山本龍生、佐橋秀紀、鈴木弘美、澤田 誠

    第38回日本分子生物学会年会・第88回日本生化学会大会合同大会 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸ポートアイランド   Country:Japan  

  23. ミクログリアのサブタイプイメージング

    鈴木弘美

    先端総合イメージングセミナー2015 

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    Event date: 2015.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名鉄ニューグランドホテル   Country:Japan  

  24. Detection of Aβ1-40 monomer/polymers on mouse brain sections by LMD-based MS imaging

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    Event date: 2014.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  25. グリア前駆細胞株OS3のチャネルロドプシン2を介したオリゴデンドロサイトへの分化

    小野健治、滝戸悠平、山本龍生、佐橋秀紀,呉起、鈴木弘美、澤田誠

    第86回日本生化学会大会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜   Country:Japan  

  26. Glutamate release from astrocyte cell-line GL261 by photo-activated channelrhodopsin-2

    Ono Kenji, Higa Madoka, Tabata Kaori, Suzuki Hiromi, Sawada Makoto

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    Event date: 2013.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  27. チャネルロドプシン2を導入したOS3グリア前駆細胞株における細胞分化の光制御

    小野健治、山本龍生、佐橋秀紀、鈴木弘美、澤田 誠

    第85回日本生化学会大会 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡国際会議場   Country:Japan  

  28. ChR2を導入した神経系前駆細胞株OS3細胞における細胞分化の光制御

    小野 健治,山本 龍生,佐橋 秀紀,鈴木 弘美,澤田誠

    第35回日本神経科学大会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋国際会議場   Country:Japan  

  29. 活性化に伴いiNOSを発現する細胞をMRIで可視化する方法の開発

    小野健治、田畑香織、鈴木弘美、澤田誠

    第34回日本神経科学大会 

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    Event date: 2011.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜   Country:Japan  

  30. 浸透圧性脱髄ラットモデルにおける脱髄病変内ミクログリアの遺伝子発現プロファイル

    鈴木陽之、椙村益久、岩間信太郎、清田敦、鈴木弘美、長崎弘、有馬寛、澤田 誠、大磯ユタカ 

    第84回日本内分泌学会学術総会 

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    Event date: 2011.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸国際会議場(神戸)   Country:Japan  

  31. Control of activation in ChR2-expressing astrocytes by blue light exposure

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    Event date: 2010.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  32. Comparative analysis of gene expression profiles of microglia from demyelinative lesions in osmotic demyelination syndrome rat model International conference

    10th International Congress of Neuroimmunology 

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    Event date: 2010.10

    Language:English   Presentation type:Poster presentation  

  33. Control of activation in ChR2-expressing astrocytes by blue light exposure

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    Event date: 2010.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  34. 頭の中のよい脳と悪い脳

    鈴木弘美

    名古屋大学環境医学研究所市民公開講座 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  35. Protective effects of minocycline on osmotic demyelination syndrome in rats International conference

    Neuroscience 2009 

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    Event date: 2009.10

    Language:English   Presentation type:Poster presentation  

  36. Neuroprotective or neurotoxic phenotypes of activated microglia in neonatal mice in neronal injuries

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    Event date: 2009.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  37. Protective roles of brain-migrated immature bone marrow cells against NO-dependent neurotoxicityi n a brain injury

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    Event date: 2009.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  38. Minocycline prevents osmotic demyelination by inhibiting the activation of microglia in rats. International conference

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    Event date: 2009.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  39. SIADHモデルラットにおいてミノサイクリンは浸透圧性脱随の発症・進展を防止する

    鈴木陽之、椙村益久、岩間信太郎、鈴木弘美、有馬 寛、澤田 誠、大磯ユタカ

    第36回日本神経内分泌学会学術集会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  40. *A practical preparation of [18F]FEPPA using a protic solvent system International conference

    18th International Symposium on Radiopharmaceutical Sciences 

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    Event date: 2009.7

    Language:English   Presentation type:Poster presentation  

  41. Enhancement of glioma formation and growth by brain-migrated immature bone marrow cells

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    Event date: 2008.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  42. The expression of proinflammatory cytokines and neurotrophins in glia in osmotic demyelination syndrome International conference

    Society for Neuroscience 

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    Event date: 2008.11

    Language:English   Presentation type:Poster presentation  

  43. 脳損傷モデルマウスにおける脳移行性骨髄細胞の神経保護効果

    小野健治、山本奈穂、鈴木弘美、佐藤愛美、澤田 誠

    第51回神経化学会大会 

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    Event date: 2008.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  44. 脳移行性骨髄細胞の脳腫瘍形成・増殖に対する促進的関与

    小野健治、古川大記、鈴木弘美、佐藤愛美、澤田 誠

    第31回神経科学学会 

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    Event date: 2008.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  45. 新規抹消性ベンゾジアゼピン受容体製剤:{18F}FEPPA PETとパーキンソン病モデルラットを用いた活性化ミクログリアのイメージング

    鈴木弘美、外山宏、籏野健太郎、工藤 元、伊藤文隆、小野健治、加藤隆司、Alan Wilson,伊藤健吾、市瀬正則、澤田 誠

    第3回日本分子イメージング学会 

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    Event date: 2008.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  46. 浸透圧性脱髄症候群ラットッモデルにおけるグリア細胞の各種サイトカイン及び神経栄養因子の発現解析の検討

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    Event date: 2008.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  47. Expressionof Cytokins and Neurotrophins after acute Subarachnoid Hemorrhage. International conference

    International Stroke Conference 2008 

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    Event date: 2008.2

    Language:English   Presentation type:Oral presentation (general)  

  48. 脳損傷モデルマウスにおける脳移行性骨髄細胞の活性化と分化に関する解析

    小野健治、山本奈穂、鈴木弘美、佐藤愛美、神澤孝夫、澤田 誠

    第30回日本分子生物学会年会・第80回日本生化学会大会 

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    Event date: 2007.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  49. 動物PETによるラット線条体障害モデルにおけるミクログリア毒性転換の検討

    鈴木弘美、外山 宏、籏野健太郎、工藤 元、伊藤文隆、小野健治、加藤隆司、伊藤健吾、澤田 誠

    第12回グリア研究会 

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    Event date: 2007.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  50. 動物PETによるラット線条体障害モデルにおけるミクログリア毒性転換の検討

    鈴木弘美、外山宏、籏野健太郎、工藤元、伊藤文隆、小野健治、加藤隆司、伊藤健吾、澤田誠

    第16回日本バイオイメージング学会学術集会 

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    Event date: 2007.11

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  51. 脳損傷モデルマウスにおける脳移行性骨髄細胞の活性化と分化のイメージング

    小野健治、山本奈穂、鈴木弘美、神澤孝夫、澤田 誠

    第50回日本神経化学会(横浜)大会 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  52. 動物PETによるラット線条体障害モデルにおけるミクログリア毒性転換の検討

    伊藤文隆、工藤 元、外山 宏、鈴木弘美、籏野健太郎、加藤隆司、片田和広、市瀬正則、澤田 誠、伊藤健吾

    第2回日本分子イメージング学会総会・学術集会 

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    Event date: 2007.6

    Language:Japanese   Presentation type:Poster presentation  

  53. Imaging of activated microglia in brain injury

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    Event date: 2006.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  54. Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. International conference

    20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Gongress 

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    Event date: 2006.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  55. 1.5T MRIによる定位的ラット脳線条体撮像ー定位脳固定具を用いない撮像法の開発

    伊藤文隆, 工藤 元, 外山 宏, 鈴木弘美, 旗野健太郎, 中根正人, 大橋正夫, 加藤隆司, 片田和広, 市瀬正則, 澤田 誠, 伊藤健吾

    日本分子イメージング学会設立総会および第1回学術集会 

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    Event date: 2006.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  56. 末梢性ベンゾジアゼピン受容体製剤11C-CB148と11C-PK11195の比較―動物PETによる検討

    関亦克彦,籏野健太郎,外山 宏,鈴木弘美,加藤隆司,片田和廣,澤田 誠, 伊藤健吾

    第45回日本核医学会総会 

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    Event date: 2005.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  57. 活性型ミクログリアのIn Vivoイメージング

    鈴木弘美, 外山 宏, 工藤 元, 籏野健太郎, 関亦克彦, 小野健治, 中根正人, 加藤隆司, 伊藤健吾, 澤田 誠

    第14回日本バイオイメージング学会学術集会 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  58. HIV-Nefを導入したミクログリア細胞による神経細胞機能障害

    澤田 誠,三井健一,鈴木弘美,小野健治,Karl-Heinz Krause,鈴木和男

    第16回日本生体防御学術集会 

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    Event date: 2005.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  59. 末梢性ベンゾジアゼピン受容体製剤11C-CB148と11C-PK11195の比較―動物PETによる検討

    工藤元,関亦克彦,籏野健太郎、外山宏,鈴木弘美,加藤隆司,片田和廣,澤田 誠,伊藤健吾

    核医学会中部地方会 

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    Event date: 2005.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  60. 活性型ミクログリアのIn Vivoイメージング

    鈴木弘美, 外山宏, 工藤元, 旗野健太郎, 関亦克彦,小野健治, 加藤隆司, 伊藤健吾,澤田 誠

    第9回ニューロイメージングカンファランス 

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    Event date: 2005.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 8

  1. 神経変性疾患の創薬標的たるマイクログリア特異的発現分子のPETイメージングの開発

    Grant number:18H02776  2018.4 - 2021.3

    国立研究開発法人 国立長寿医療研究センター  基盤研究 (B) 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\150

  2. シグナルペプチド:細胞外微粒子機能の新規マーカー

    2018.10

    CREST 

    鈴木弘美

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  3. Role of diabetes and inflammation on microglial cell biology and transformation International coauthorship

    2020.10

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    Authorship:Coinvestigator(s)  Grant type:Collaborative (industry/university)

    Grant amount:\8700863 ( Direct Cost: \8700863 )

  4. LMD技術に関する研究

    2020.4 - 2020.10

    国内共同研究 

    鈴木弘美

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    Authorship:Coinvestigator(s)  Grant type:Collaborative (industry/university)

    Grant amount:\882320

  5. 中枢作用のある薬剤の単一細胞質量分析による動態解析

    2019.4

    国内共同研究 

    鈴木弘美

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    Authorship:Coinvestigator(s)  Grant type:Collaborative (industry/university)

    Grant amount:\1729700 ( Direct Cost: \1729700 )

  6. 標的化技術の評価にかかる共同研究

    2010.6 - 2011.3

    国内共同研究 

  7. 脳疾患に対する新規機能抗体の開発とその応用

    2010.6

    国内共同研究 

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    株化ミクログリアを用いて細胞膜上の生体情報授受に関わる受容体に対する抗体を取得し、新規の機能抗体の開発と応用を目指す。

  8. 脳標的化薬物送達を目的とするシャトルステーション型のステントの開発

    2009.8 - 2010.3

    A-step 

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    Grant type:Competitive

    現在、気道・胆管・血管などの狭窄部位挿入し、内側から広げ支える治療器具として使用されている合金製ステントを、埋め込み型の薬剤除去システム【シャトルステーション型ステント】として改良し実用化を目指すものである。提案期間には模擬生体内条件から小動物血管を用いた利用効率を検討する。

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Industrial property rights 3

  1. 金属コロイド粒子を含有する脳神経細胞内移行用キャリア

    澤田誠、鈴木弘美

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    Application no:PCT/JP2005/001761  Date applied:2005.2

    Country of applicant:Domestic  

  2. 多価結合手を有し代謝安定性が向上した脳移行性ポリペプチド

    中條智洋、原啓高、山本一匡、鈴木弘美、澤田誠、須原哲也、樋口真人、原田平輝志、季斌

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    Application no:特願2007-054260  Date applied:2007.3

    Country of applicant:Domestic  

  3. PESI-MSでのイオン化の効率を上げる手法

    澤田 誠

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    Application no:WUS0001418 

 

Teaching Experience (On-campus) 6

  1. ベーシックトレーニング

    2020

  2. 基礎医学セミナー

    2020

  3. ベーシックトレーニング

    2019

  4. 基礎医学セミナー

    2019

  5. 基礎医学セミナー

    2018

  6. ベーシックトレーニング

    2010

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Teaching Experience (Off-campus) 2

  1. 大学院講義

    2019.4 - 2020.3 Fujita Health University)

  2. 2018.4 - 2019.3 Fujita Health University)