University of Chicago   Department of Medicine   Research Associate (Assistant Professor)

1994.11 - 1995.3

University of Chicago   Department of Medicine   Researcher

1991.11 - 1994.10

日本病態栄養学会

日本分子生物学会

日本生理学会

Impaired Fat Absorption from Intestinal Tract in High-Fat Diet Fed Male Mice Deficient in Proglucagon-Derived Peptides Reviewed

Nishida, K; Ueno, S; Seino, Y; Hidaka, S; Murao, N; Asano, Y; Fujisawa, H; Shibata, M; Takayanagi, T; Ohbayashi, K; Iwasaki, Y; Iizuka, K; Okuda, S; Tanaka, M; Fujii, T; Tochio, T; Yabe, D; Yamada, Y; Sugimura, Y; Hirooka, Y; Hayashi, Y; Suzuki, A

NUTRIENTS   Vol. 16 ( 14 )   2024.7

Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon-derived peptides Reviewed

Ueno, S; Seino, Y; Hidaka, S; Nakatani, M; Hitachi, K; Murao, N; Maeda, Y; Fujisawa, H; Shibata, M; Takayanagi, T; Iizuka, K; Yabe, D; Sugimura, Y; Tsuchida, K; Hayashi, Y; Suzuki, A

JOURNAL OF DIABETES INVESTIGATION   Vol. 14 ( 9 ) page： 1045 - 1055   2023.9

A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon-derived peptide levels Reviewed

Kobayashi, M; Maruyama, N; Yamamoto, Y; Togawa, T; Ida, T; Yoshida, M; Miyazato, M; Kitada, M; Hayashi, Y; Kashiwagi, A; Kitamura, T

JOURNAL OF DIABETES INVESTIGATION   Vol. 14 ( 5 ) page： 648 - 658   2023.5

An analysis of intestinal morphology and incretin-producing cells using tissue optical clearing and 3-D imaging Reviewed

Hatoko, T; Harada, N; Tokumoto, S; Yamane, S; Ikeguchi-Ogura, E; Kato, T; Yasuda, T; Tatsuoka, H; Shimazu-Kuwahara, S; Yabe, D; Hayashi, Y; Inagaki, N

SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page： 17530   2022.10

High Protein Diet Feeding Aggravates Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides Reviewed

Ueno, S; Seino, Y; Hidaka, S; Maekawa, R; Takano, Y; Yamamoto, M; Hori, M; Yokota, K; Masuda, A; Himeno, T; Tsunekawa, S; Kamiya, H; Nakamura, J; Kuwata, H; Fujisawa, H; Shibata, M; Takayanagi, T; Sugimura, Y; Yabe, D; Hayashi, Y; Suzuki, A

NUTRIENTS   Vol. 14 ( 5 )   2022.3

Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids Reviewed

Fujiwara Yuta, Yamane Shunsuke, Harada Norio, Ikeguchi-Ogura Eri, Usui Ryota, Nakamura Toshihiro, Iwasaki Kanako, Suzuki Kazuyo, Yabe Daisuke, Hayashi Yoshitaka, Inagaki Nobuya

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY   Vol. 320 ( 4 ) page： G617 - G626   2021.4

Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in -cell Mass Independent of Body Weight Gain in Mice Reviewed

Masuda Atsushi, Seino Yusuke, Murase Masatoshi, Hidaka Shihomi, Shibata Megumi, Takayanagi Takeshi, Sugimura Yoshihisa, Hayashi Yoshitaka, Suzuki Atsushi

NUTRIENTS   Vol. 11 ( 5 )   2019.5

Acute Cholesterol-Lowering Effect of Exendin-4 in Ldlr(-/-) and C57BL/6J Mice. Reviewed

Hori M, Hasegawa Y, Hayashi Y, Nakagami T, Harada-Shiba M

Journal of atherosclerosis and thrombosis     2022.3

Carbohydrate-induced weight gain models for diabetes research: contribution of incretins and parasympathetic signal. Reviewed

Seino Y, Murase M, Hayashi Y, Suzuki A

Journal of diabetes investigation   Vol. 12 ( 1 ) page： 3 - 5   2021.1

Glucagon regulates lipolysis and fatty acid oxidation through inositol triphosphate receptor 1 in the liver Reviewed

Hayashi Yoshitaka

JOURNAL OF DIABETES INVESTIGATION   Vol. 12 ( 1 ) page： 32 - 34   2021.1

Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice Reviewed

Motegi Mikio, Himeno Tatsuhito, Nakai-Shimoda Hiromi, Inoue Rieko, Ozeki Norio, Hayashi Yusuke, Sasajima Sachiko, Mohiuddin Mohammad Sarif, Asano-Hayami Emi, Kato Makoto, Asano Saeko, Miura-Yura Emiri, Morishita Yoshiaki, Kondo Masaki, Tsunekawa Shin, Kato Yoshiro, Kato Koichi, Naruse Keiko, Seino Yusuke, Hayashi Yoshitaka, Nakamura Jiro, Kamiya Hideki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 532 ( 1 ) page： 47 - 53   2020.10

Sphingosine kinase 1–interacting protein is a dual regulator of insulin and incretin secretion Reviewed

Yanyan Liu, Shin Ichi Harashima, Yu Wang, Kazuyo Suzuki, Shinsuke Tokumoto, Ryota Usui, Hisato Tatsuoka, Daisuke Tanaka, Daisuke Yabe, Norio Harada, Yoshitaka Hayashi, Nobuya Inagaki

FASEB Journal   Vol. 33 ( 5 ) page： 6239 - 6253   2019.5

Two Mutations in Thyroid Hormone Receptor Beta Gene (P453A and C36Y) in a Family with Resistance to Thyroid Hormone with Comorbid Myotonic Dystrophy. Reviewed

Takeda K, Nemoto KI, Hayashi Y, Yamamoto M, Sakuta R, Kimura T, Noto H

Thyroid : official journal of the American Thyroid Association   Vol. 29 ( 4 ) page： 607 - 608   2019.4

The Mutant Thyroid Hormone Receptor Beta R320P Causes Syndrome of Resistance to Thyroid Hormone Reviewed

Kimura Tetsuya, Hayashi Yoshitaka, Tsukamoto Yuka, Okamoto Yasuyuki

CASE REPORTS IN ENDOCRINOLOGY   Vol. 2018   page： 4081769   2018

Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice. Reviewed

Ryuya Maekawa, Yusuke Seino, Hidetada Ogata, Masatoshi Murase, Atsushi Iida, Kaori Hosokawa, Erina Joo, Norio Harada, Shin Tsunekawa, Yoji Hamada, Yutaka Oiso, Nobuya Inagaki, Yoshitaka Hayashi, Hiroshi Arima

J Nutr Biochem   Vol. 49   page： 71-79   2017.11

Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice Reviewed

Maekawa, R; Seino, Y; Ogata, H; Murase, M; Iida, A; Hosokawa, K; Joo, E; Harada, N; Tsunekawa, S; Hamada, Y; Oiso, Y; Inagaki, N; Hayashi, Y; Arima, H

JOURNAL OF NUTRITIONAL BIOCHEMISTRY   Vol. 49   page： 71 - 79   2017.11

Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Reviewed

Atsushi Iida, Yusuke Seino, Ayako Fukami, Ryuya Maekawa, Daisuke Yabe, Shinobu Shimizu, Keita Kinoshita, Yusuke Takagi, Takako Izumoto, Hidetada Ogata, Kota Ishikawa, Nobuaki Ozaki, Shin Tsunekawa, Yoji Hamada, Yutaka Oiso, Hiroshi Arima, Yoshitaka Hayashi,

Diabetologia   Vol. 59 ( 7 ) page： 1533-1541   2016.4

Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity.

Takagi Y, Kinoshita K, Ozaki N, Seino Y, Murata Y, Oshida Y, Hayashi Y.

PLoS One.   Vol. 10 ( 9 ) page： e0138322   2015.9

Chronic Hyponatremia Causes Neurologic and Psychologic Impairments.

Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Fukumoto K, Iwama S, Takagishi Y, Hayashi Y, Arima H, Komatsu Y, Murata Y, Oiso Y.

J Am Soc Nephrol.     page： Epub ahead of print   2015.9

*Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides.

Takano Y, Kasai K, Takagishi Y, Kikumori T, Imai T, Murata Y, Hayashi Y.

PLoS ONE   Vol. 10 ( 7 ) page： e0133812   2015.7

グルカゴンの真の特異的作用は何か？グルカゴン作用欠損モデルの表現型.

林　良敬

実験医学   Vol. 33 ( 6 ) page： 897-902   2015.4

Low temperature-induced circulating triiodothyronine accelerates seasonal testicular regression.

K. Ikegami, Y. Atsumi, E. Yonenaga, H. Ono, I. Murayama, Y. Nakane, W. Ota, N. Arai, A. Tega, M. Iigo, V. M. Darras, K. Tsutsui, Y. Hayashi, S. Yoshida, Y. Yoshimura

Endocrinology   Vol. 156 ( 2 ) page： 647-659   2015.2

Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.

Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, Iwasaki K, Nasteska D, Harada T, Hayashi Y, Adachi Y, Owada Y, Takayanagi R, Inagaki N.

Am J Physiol Endocrinol Metab.   Vol. 308 ( 7 ) page： E583-E591   2015.1

Activation of the RhoB signaling pathway by thyroid hormone receptor ß in thyroid cancer cells.

Ichijo S, Furuya F, Shimura H, Hayashi Y, Takahashi K, Ohta K, Kobayashi T, Kitamura K.

PLoS One   Vol. 9 ( 12 ) page： e116252   2014.12

Glucagon is essential for adaptive thermongenesis in brown adipose tissue Reviewed

K. Kinoshita, N. Ozaki, Y. Takagi, Y. Murata, Y. Oshida, Y. Hayashi

Endocrinology   Vol. 155 ( 9 ) page： 3484-3492   2014.6

KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. Reviewed

H. Ogata, Y. Seino, N. Harada, A. Iida, K. Suzuki, T. Izumoto, K. Ishikawa, E. Uenishi, N. Ozaki, Y. Hayashi, T. Miki, N. Inagaki, S. Tsunekawa, Y. Hamada, S. Seino, Y. Oiso

Journal of ENdocrinology   Vol. 222 ( 2 ) page： 191-200   2014.6

Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice.

Okawa T, Kamiya H, Himeno T, Seino Y, Tsunekawa S, Hayashi Y, Harada N, Yamada Y, Inagaki N, Seino Y, Oiso Y, Nakamura J.

J Diabetes Investig   Vol. 5 ( 1 ) page： 31-37   2013.10

Hyperthyroidism due to thyroid-stimulating hormone secretion after surgery for Cushing's syndrome: a novel cause of the syndrome of inappropriate secretion of thyroid-stimulating hormone. Reviewed

D. Tamada, T. Onodera, T. Kitamura, Y. Yamamoto, Y. Hayashi, Y. Murata, M. Otsuki, I. Shimomura

J Clin Endocrinol Metab   Vol. 98 ( 7 ) page： 2656-2662   2013.5

Aristaless-related homeobox plays a key role in hyperplasia of the pancreas islet α-like cells in mice deficient in proglucagon-derived peptides. Reviewed

S. Xu, Y. Hayashi, Y. Takagishi, M. Itoh, Y. Murata

PLoS One   Vol. 8 ( 5 ) page： e64415   2013.5

Ectopic expression of GIP in pancreatic ß-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Reviewed

A. Fukami, Y. Seino, N. Ozaki, M. Yamamoto, C. Sugiyama, E. Sakamoto-Miura, T. Himeno, Y. Takagishi, S. Tsunekawa, S. Ali, D. J. Drucker, Y. Murata, Y. Seino, Y. Oiso, Y. Hayashi

Diabetes     page： doi: 10.2337/db12-0294   2012.10

グルカゴンによる代謝制御 Invited

林　良敬

糖尿病と代謝   Vol. 40 ( 3 ) page： 1-8   2012.9

Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides. Reviewed

C. Sugiyama, M. Yamamoto, T. Kotani, F. Kikkawa, Y. Murata, Y. Hayashi

Plos One     2012.8

Isolated growth hormone deficiency in two siblings because of paternal mosaicism for a mutation in the GH1 gene. Reviewed

M. Tsubahara, Y. Hayashi, S. Niijima, M. Yamamoto, T. Kamijo, Y. Murata, H. Haruna, A. Okumura, T. Shimizu

Clin Endocrinol (Oxf.)   Vol. 76 ( 3 ) page： 420-424   2012.3

Aberrant promoter methylation in overexpression of CITED1 in papillary thyroid cancer. Reviewed

M. Sassa, Y. Hayashi, R. Watanabe, T. Kikumori, T. Imai, J. Kurebayashi, T. Kiuchi, Y. Murata

Thyroid   Vol. 21 ( 5 ) page： 511-517   2011.5

A novel Caspr mutation causes the shambling mouse phenotype by disrupting axo-glial interactions of myelinated nerves. Reviewed

X.Y. Sun, Y. Takagishi, E. Okabe, Y. Chishima, Y. Kanou, S. Murase, K. Mizumura, M. Inaba, Y. Komatsu, Y. Hayashi, E. Peles, S. Oda, Y. Murata

J Neuropathol Exp Neurol   Vol. 68 ( 11 ) page： 1207-1218   2009.11

Possible involvement of BRAFV600E in altered gene expression in papillary thyroid cancer. Invited Reviewed

R. Watanabe, Y. Hayashi, M. Sassa, T. Kikumori, T. Imai, T. Kiuchih, Y. Murata

Endocr J   Vol. 56   page： 407-414   2009.6

Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Reviewed

Y. Sugimura, T. Murase, K. Oyama, A. Uchida, N. Sato, S. Hayasaka, Y. Kano, Y. Takagishi, Y. Hayashi, Y. Oiso, Y. Murata

Diabetologia   Vol. 56   page： 962-971   2009.5

Oculocutaneous Albinism in Suncus murinus: Establishment of a Strain and Identification of its Responsible Gene. Reviewed

K. Tsuboi, Y. Hayashi, T. Jogahara, G. Ogura, Y. Murata,S. Oda

Exp Anim   Vol. 58 ( 1 ) page： 31-40   2009.1

Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains. Reviewed

Ido H, Ito S, Taniguchi Y, Hayashi M, Sato-Nishiuchi R, Sanzen N, Hayashi Y, Futaki S, Sekiguchi K

J Biol Chem   Vol. 283 ( 42 ) page： 28149-28157   2008.10

Identification of genes differentially expressed in mouse fetuses from streptozotocin-induced diabetic pregnancy by cDNA subtraction. Reviewed

Sato N, Sugimura Y, Hayashi Y, Murase T, Kanou Y, Kikkawa F, Murata Y

Endocr J   Vol. 55 ( 2 ) page： 317-323   2008.5

Insertion of an intracisternal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice. Reviewed

Sun XY, Chen ZY, Hayashi Y, Kanou Y, Takagishi Y, Oda S, Murata Y

Gene   Vol. 411 ( 1-2 ) page： 94-102   2008.3

Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile. Reviewed

R.Q. Shi, J. K. Lee, Y. Hayashi, Y. Takeuchi, F. Kambe, S. Futaki, H. Seo, Y. Murata, I. Kodama

Eur J Parmacol   Vol. 578   page： 270-278   2008

Mapping of jog locus to the region between D6Mit104 and D6Mit336 on mouse chromosome 6. Reviewed

Sun XY, Chen ZY, Kanou Y, Hayashi Y, Ohno T, Murata Y, Oda S

  Vol. 56 ( 5 ) page： 389-392   2007.10

A case with isolated growth hormone deficiency caused by compound heterozygous mutations in GH-1: a novel missense mutation in the initiation codon and a 7.6kb deletion Reviewed

Hayashi Y, Kamijo T, Yamamoto M, Murata Y, Phillips JA 3rd, Ogawa M, Seo H.

Growth Horm IGF Res   Vol. 17 ( 36 ) page： 249-253   2007.6

Molecular cloning of prostaglandin EP3 receptors from canine sensory ganglia and their facilitatory action on bradykinin-induced mobilization of intracellular calcium Reviewed

Kozaki Y, Kambe F, Hayashi Y, Ohmori S, Seo H, Kumazawa T, Mizumura K

J Neurochem   Vol. 100 ( 6 ) page： 1636-1647   2007.3

Regulation of mesodermal differentiation of mouse embryonic stem cells by basement membranes. Reviewed

Fujiwara H, Hayashi Y, Sanzen N, Kobayashi R, Weber CN, Emoto T, Futaki S, Niwa H, Murray P, Edgar D, Sekiguchi K.

J Biol Chem   Vol. 282   page： 29701-29711   2007

The Sp family of transcription factors regulates the human laminin alpha1 gene in JAR choriocarcinoma cells. Reviewed

Niimi T, Hayashi Y, Sekiguchi K, Kitagawa Y.

Biochim Biophys Acta   Vol. 2006 ( 11-12 ) page： 573-579   2006.11

A novel large-scale production system for modified basement membrane matrices using gene-swapped parietal endoderm cells. Reviewed

Hayashi Y, Weber CN, Emoto T, Fujiwara H, Sanzen N, Futaki S, Sekiguchi K.

Matrix Biol   Vol. 25 ( 2 ) page： 85-88   2006.3

Activation of the RhoB signaling pathway by thyroid hormone receptor ß in thyroid cancer cells. Reviewed

S. Ichijo, F. Furuya, H. Shimura, Y. Hayashi, K. Takahashi, K. Ohta, T. Kobayashi, K. Kitamura.

PLoS ONE   Vol. 9 ( 12 ) page： e116252   2005.12

Growth hormone releasing hormone receptor (GHRH-r) gene mutation in Indian children with familial isolated growth hormone deficiency: a study from western India Reviewed

Desai MP, Upadhye PS, Kamijo T, Yamamoto M, Ogawa M, Hayashi Y, Seo H, Nair SR.

J Pediatr Endocrinol Metab   Vol. 18 ( 10 ) page： 1955-973   2005.10

The transcriptional landscape of the mammalian genome. Reviewed

Carninci P et al FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group).

Science   Vol. 309   page： 1559-1563   2005.9

Sox7 Plays Crucial Roles in Parietal Endoderm Differentiation in F9 Embryonal Carcinoma Cells through Regulating Gata-4 and Gata-6 Expression. Reviewed

S. Futaki, Y. Hayashi, T. Emoto, C.N. Weber, K. SekiguchiS. Futaki, Y. Hayashi, T. Emoto, C.N. Weber, K. Sekiguchi

Mol Cell Biol   Vol. 24 ( 12 ) page： 10495-10503   2004.12

A nonsense mutation (E72X) in growth hormone releasing hormone receptor (GHRHR) gene is the major cause of familial isolated growth hormone deficiency in Western region of India: founder effect suggested by analysis of dinucleotide repeat polymorphism close to GHRHR gene Reviewed

Kamijo, T. Hayashi, Y. Seo, H. Yamamoto, M. Ogawa, M. Choski, C. S. Sawant, N. J. Colaco, M. P. Desai, M. P.

Growth Horm IGF Res   Vol. 14 ( 5 ) page： 394-401   2004.10

SOX7 and SOX17 Regulate the Parietal Endoderm-specific Enhancer Activity of Mouse Laminin {alpha}1 Gene Reviewed

Niimi, T. Hayashi, Y. Futaki, S. Sekiguchi, K.

J Biol Chem   Vol. 279 ( 36 ) page： 38055-38061   2004.9

Establishment and characterization of a parietal endoderm-like cell line derived from Engelbreth-Holm-Swarm tumor (EHSPEL), a possible resource for an engineered basement membrane matrix Reviewed

Hayashi, Y. Emoto, T. Futaki, S. Sekiguchi, K.

Matrix Biol   Vol. 23 ( 1 ) page： 47-62   2004.4

Molecular dissection of the alpha -dystroglycan- and integrin-binding sites within the globular domain of human laminin-10 Reviewed

Ido, H. Harada, K. Futaki, S. Hayashi, Y. Nishiuchi, R. Natsuka, Y. Li, S. Wada, Y. Combs, A. C. Ervasti, J. M. Sekiguchi, K.

J Biol Chem   Vol. 279 ( 12 ) page： 10946-10954   2004.3

Molecular basis of constitutive production of basement membrane components: Gene expression profiles of engelbreth-holm-swarm tumor and F9 embryonal carcinoma cells Reviewed

Futaki, S. Hayashi, Y. Yamashita, M. Yagi, K. Bono, H. Hayashizaki, Y. Okazaki, Y. Sekiguchi, K.

J Biol Chem   Vol. 278 ( 50 ) page： 50691-50701   2003

A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors Reviewed

Ritchie, J. W. Shi, Y. B. Hayashi, Y. Baird, F. E. Muchekehu, R. W. Christie, G. R. Taylor, P. M.

Mol Endocrinol   Vol. 17 ( 4 ) page： 653-661   2003

Identification of an upstream enhancer in the mouse laminin alpha 1 gene defining its high level of expression in parietal endoderm cells Reviewed

Niimi, T. Hayashi, Y. Sekiguchi, K.

J Biol Chem   Vol. 278 ( 11 ) page： 9332-9338   2003

Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo Reviewed

Takeuchi, Y. Murata, Y. Sadow, P. Hayashi, Y. Seo, H. Xu, J. O'Malley, B. W. Weiss, R. E. Refetoff, S.

Endocrinology   Vol. 143 ( 4 ) page： 1346-1352   2002

Type 1 iodothyronine deiodinase in the house musk shrew (Suncus murinus, Insectivora: Soricidae): cloning and characterization of complementary DNA, unique tissue distribution and regulation by T(3) Reviewed

Rogatcheva, M. Hayashi, Y. Oda, S. Seo, H. Cua, K. Refetoff, S. Murakami, M. Mori, M. Murata, Y.

Gen Comp Endocrinol   Vol. 127 ( 1 ) page： 48-58   2002

Identification and recombinant production of human laminin alpha4 subunit splice variants Reviewed

Hayashi, Y. Kim, K. H. Fujiwara, H. Shimono, C. Yamashita, M. Sanzen, N. Futaki, S. Sekiguchi, K.

Biochem Biophys Res Commun   Vol. 299 ( 3 ) page： 498-504   2002

Familial isolated growth hormone deficiency: genetics and pathophysiology Invited Reviewed

Hayashi, Y. Kamijo, T. Ogawa, M. Seo, H.

Endocr J   Vol. 49 ( 3 ) page： 265-272   2002

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha Reviewed

Macchia, P. E. Takeuchi, Y. Kawai, T. Cua, K. Gauthier, K. Chassande, O. Seo, H. Hayashi, Y. Samarut, J. Murata, Y. Weiss, R. E. Refetoff, S.

Proc Natl Acad Sci U S A   Vol. 98 ( 1 ) page： 349-354   2001

Somatic gene alteration of AIB1 gene in patients with breast cancer Reviewed

Shibata, A. Hayashi, Y. Imai, T. Funahashi, H. Nakao, A. Seo, H.

Endocr J   Vol. 48 ( 2 ) page： 199-204   2001

Involvement of AP-1 and steroidogenic factor (SF)-1 in the cAMP-dependent induction of human adrenocorticotropic hormone receptor (ACTHR) promoter Reviewed

Sarkar, D. Kambe, F. Hayashi, Y. Ohmori, S. Funahashi, H. Seo, H.

Endocr J   Vol. 47 ( 1 ) page： 63-75   2000

Identification of a novel myosin-Va mutation in an ataxic mutant rat, dilute-opisthotonus Reviewed

Futaki, S. Takagishi, Y. Hayashi, Y. Ohmori, S. Kanou, Y. Inouye, M. Oda, S. Seo, H. Iwaikawa, Y. Murata, Y.

Mamm Genome   Vol. 11 ( 8 ) page： 649-655   2000

Responsiveness to thyroid hormone is enhanced in rat hepatocytes cultured as spheroids compared with that in monolayers: altered responsiveness to thyroid hormone possibly involves complex formed on thyroid hormone response elements Reviewed

Menjo, M. Yamaguchi, S. Murata, Y. Hayashi, Y. Nagaya, T. Ohmori, S. Refetoff, S. Seo, H.

Thyroid   Vol. 9 ( 9 ) page： 959-967   1999

Glucocorticoids increase retinoid-X receptor alpha (RXRalpha) expression and enhance thyroid hormone action in primary cultured rat hepatocytes Reviewed

Yamaguchi, S. Murata, Y. Nagaya, T. Hayashi, Y. Ohmori, S. Nimura, Y. Seo, H.

J Mol Endocrinol   Vol. 22 ( 1 ) page： 81-90   1999

A Japanese family with autosomal dominant growth hormone deficiency Reviewed

Saitoh, H. Fukushima, T. Kamoda, T. Tanae, A. Kamijo, T. Yamamoto, M. Ogawa, M. Hayashi, Y. Ohmori, S. Seo, H.

Eur J Pediatr   Vol. 158 ( 8 ) page： 624-627   1999

9-cis-retinoic acid decreases the level of its cognate receptor, retinoid X receptor, through acceleration of the turnover Reviewed

Nomura, Y. Nagaya, T. Hayashi, Y. Kambe, F. Seo, H.

Biochem Biophys Res Commun   Vol. 260 ( 3 ) page： 729-733   1999

A novel mutation at the donor splice site of intron 3 of the GH-I gene in a patient with isolated growth hormone deficiency Reviewed

Hayashi, Y. Kamijo, T. Yamamoto, M. Ohmori, S. Phillips, J. A., 3rd Ogawa, M. Igarashi, Y. Seo, H.

Growth Horm IGF Res   Vol. 9 ( 6 ) page： 434-437   1999

Mutations in intron 3 of GH-1 gene associated with isolated GH deficiency type II in three Japanese families Reviewed

Kamijo, T. Hayashi, Y. Shimatsu, A. Kinoshita, E. Yoshimoto, M. Ogawa, M. Seo, H.

Clin Endocrinol (Oxf)   Vol. 51 ( 3 ) page： 355-360   1999

Hereditary isolated growth hormone deficiency caused by GH1 gene mutations in Japanese patients

Kamijo, T. Hayashi, Y. Seo, H. Ogawa, M.

Growth Horm IGF Res   Vol. 9 ( suppl B ) page： 31-34   1999

Inhibition of growth hormone (GH) secretion by a mutant GH-I gene product in neuroendocrine cells containing secretory granules: an implication for isolated GH deficiency inherited in an autosomal dominant manner Reviewed

Hayashi, Y. Yamamoto, M. Ohmori, S. Kamijo, T. Ogawa, M. Seo, H.

J Clin Endocrinol Metab   Vol. 84 ( 6 ) page： 2134-2139   1999

Polymorphism of homopolymeric glutamines in coactivators for nuclear hormone receptors Reviewed

Hayashi, Y. Yamamoto, M. Ohmori, S. Kikumori, T. Imai, T. Funahashi, H. Seo, H.

Endocr J   Vol. 46 ( 2 ) page： 279-284   1999

Selective pituitary resistance to thyroid hormone produced by expression of a mutant thyroid hormone receptor beta gene in the pituitary gland of transgenic mice Reviewed

Hayashi, Y. Xie, J. Weiss, R. E. Pohlenz, J. Refetoff, S.

Biochem Biophys Res Commun   Vol. 245 ( 1 ) page： 204-10   1998

Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice Reviewed

Weiss, R. E. Murata, Y. Cua, K. Hayashi, Y. Seo, H. Refetoff, S.

Endocrinology   Vol. 139 ( 12 ) page： 4945-4952   1998

Molecular cloning of sucrase-isomaltase cDNA in the house musk shrew Suncus murinus and identification of a mutation responsible for isolated sucrase deficiency Reviewed

Ito, T. Hayashi, Y. Ohmori, S. Oda, S. Seo, H.

J Biol Chem   Vol. 273 ( 26 ) page： 16464-16469   1998

Tumor suppressor p53 is a negative regulator in thyroid hormone receptor signaling pathways Reviewed

Bhat, M. K. Yu, C. Yap, N. Zhan, Q. Hayashi, Y. Seth, P. Cheng, S.

J Biol Chem   Vol. 272 ( 46 ) page： 28989-28983   1997

Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3'-triiodothyroinine binding affinity Reviewed

Yagi, H. Pohlenz, J. Hayashi, Y. Sakurai, A. Refetoff, S.

J Clin Endocrinol Metab   Vol. 82 ( 5 ) page： 1608-1614   1997

A splicing variant of Steroid Receptor Coactivator-1 (SRC-1E): the major isoform of SRC-1 to mediate thyroid hormone action Reviewed

Hayashi, Y. Ohmori, S. Ito, T. Seo, H.

Biochem Biophys Res Commun   Vol. 236 ( 1 ) page： 83-87   1997

Modification of thyroid hormone and 9-cis retinoic acid signaling by overexpression of their cognate receptors using adenoviral vector Reviewed

Hayashi, Y. Yamaguchi, S. Pohlenz, J. Murata, Y. Refetoff, S. Seo, H.

Mol Cell Endocrinol   Vol. 131 ( 1 ) page： 59-66   1997

A mouse model of resistance to thyroid hormone produced by somatic gene transfer of a mutant thyroid hormone receptor Reviewed

Hayashi, Y. Mangoura, D. Refetoff, S.

Mol Endocrinol   Vol. 10 ( 1 ) page： 100-106   1996

Dominant inheritance of resistance to thyroid hormone not linked to defects in the thyroid hormone receptor alpha or beta genes may be due to a defective cofactor Reviewed

Weiss, R. E. Hayashi, Y. Nagaya, T. Petty, K. J. Murata, Y. Tunca, H. Seo, H. Refetoff, S.

J Clin Endocrinol Metab   Vol. 81 ( 12 ) page： 4196-4203   1996

Resistance to thyrotropin and other abnormalities of the thyrotropin receptor

Refetoff, S. Sunthornthepvarakul, T. Gottschalk, M. E. Hayashi, Y.

Recent Prog Horm Res   Vol. 51   page： 97-120   1996

Thyroxine-binding globulin: organization of the gene and variants Reviewed

Refetoff, S. Murata, Y. Mori, Y. Janssen, O. E. Takeda, K. Hayashi, Y.

Horm Res   Vol. 45 ( 3-5 ) page： 128-138   1996

Expression of thyroid peroxidase in EBV-transformed B cell lines using adenovirus Reviewed

Hidaka, Y. Hayashi, Y. Fisfalen, M. E. Suzuki, S. Takeda, T. Refetoff, S. DeGroot, L. J.

Thyroid   Vol. 6 ( 1 ) page： 23-28   1996

Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase Reviewed

Eggerickx, D. Denef, J. F. Labbe, O. Hayashi, Y. Refetoff, S. Vassart, G. Parmentier, M. Libert, F.

Biochem J   Vol. 309 ( 3 ) page： 837-843   1995

Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants Reviewed

Yen, P. M. Wilcox, E. C. Hayashi, Y. Refetoff, S. Chin, W. W.

Endocrinology   Vol. 136 ( 7 ) page： 2845-2851   1995

Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene Reviewed

Sunthornthepvarakul, T. Gottschalk, M. E. Hayashi, Y. Refetoff, S.

N Engl J Med   Vol. 332 ( 3 ) page： 155-160   1995

Expression of human thyrotropin receptor by recombinant adenovirus Reviewed

Okamoto, Y. Hayashi, Y. DeGroot, L. J.

Thyroid   Vol. 5 ( 1 ) page： 51-53   1995

Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors? Reviewed

Hayashi, Y. Weiss, R. E. Sarne, D. H. Yen, P. M. Sunthornthepvarakul, T. Marcocci, C. Chin, W. W. Refetoff, S.

J Clin Endocrinol Metab   Vol. 80 ( 11 ) page： 3246-3256   1995

Expression of a thyroid hormone-responsive recombinant gene introduced into adult mice livers by replication-defective adenovirus can be regulated by endogenous thyroid hormone receptor Reviewed

Hayashi, Y. DePaoli, A. M. Burant, C. F. Refetoff, S.

J Biol Chem   Vol. 269 ( 39 ) page： 23872-23875   1994

A new point mutation (C446R) in the thyroid hormone receptor-beta gene of a family with resistance to thyroid hormone Reviewed

Weiss, R. E. Chyna, B. Duell, P. B. Hayashi, Y. Sunthornthepvarakul, T. Refetoff, S.

J Clin Endocrinol Metab   Vol. 78 ( 5 ) page： 1253-1256   1994

Polymorphism of a variant human thyrotropin receptor (hTSHR) gene Reviewed

Sunthornthepvarakul, T. Hayashi, Y. Refetoff, S.

Thyroid   Vol. 4 ( 2 ) page： 147-149   1994

An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families Reviewed

Sunthornthepvarakul, T. Angkeow, P. Weiss, R. E. Hayashi, Y. Refetoff, S.

Biochem Biophys Res Commun   Vol. 202 ( 2 ) page： 781-787   1994

Resistance to thyroid hormone in subjects from two unrelated families is associated with a point mutation in the thyroid hormone receptor beta gene resulting in the replacement of the normal proline 453 with serine Reviewed

Refetoff, S. Weiss, R. E. Wing, J. R. Sarne, D. Chyna, B. Hayashi, Y.

Thyroid   Vol. 4 ( 3 ) page： 249-254   1994

Mutations of CpG dinucleotides located in the triiodothyronine (T3)-binding domain of the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to thyroid hormone Reviewed

Hayashi, Y. Sunthornthepvarakul, T. Refetoff, S.

J Clin Invest   Vol. 94 ( 2 ) page： 607-615   1994

Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation Reviewed

Hayashi, Y. Mori, Y. Janssen, O. E. Sunthornthepvarakul, T. Weiss, R. E. Takeda, K. Weinberg, M. Seo, H. Bell, G. I. Refetoff, S.

Mol Endocrinol   Vol. 7 ( 8 ) page： 1049-1060   1993

The relative expression of mutant and normal thyroid hormone receptor genes in patients with generalized resistance to thyroid hormone determined by estimation of their specific messenger ribonucleic acid products Reviewed

Hayashi, Y. Janssen, O. E. Weiss, R. E. Murata, Y. Seo, H. Refetoff, S.

J Clin Endocrinol Metab   Vol. 76 ( 1 ) page： 64-69   1993

Modification of water and electrolyte metabolism during head-down tilting by hypoglycemia in men Reviewed

Hayashi, Y. Murata, Y. Seo, H. Miyamoto, N. Kambe, F. Ohmori, S. Yamamoto, C. Hayamizu, S. Tamura, Y. Matsui, N.

J Appl Physiol   Vol. 73 ( 5 ) page： 1785-1790   1992

グルカゴン様ペプチド-1産生細胞の分離ー発生工学的手法を用いて

2007.9 - 2009.3

学術研究助成 

プレプログルカゴン遺伝子発現を指標とした膵島発生分化機構の解析

2006.9

報彰基金研究奨励 

膵島の発生・新生における血管神経ワイヤリング形成とリモデリングの機構の解析

2011.4 - 2013.3

科学研究費補助金  新学術領域研究、課題番号：23122507

腸管上皮・内分泌細胞をターゲットとした新規治療戦略の創出

2009.4 - 2012.3

科学研究費補助金  挑戦的萌芽研究

脳・神経系における甲状腺ホルモン作用の解析ー海馬などにおける新規標的遺伝子の探索

2006.4 - 2008.3

科学研究費補助金  基盤研究(C)

林　良敬

Homeostatic regulation of amino acid metabolism through the viewpoint of glucagon and liver zonation.

Grant number：22H03508  2022.4 - 2027.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Exploration of homeostastic regulation of amino acid metabolism-through the analyses of glucagon action and liver zonation.

Grant number：23K24765  2022.4 - 2027.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

栄養素感知に関わる腸管内分泌ホルモン分泌機構の統合的解析

Grant number：20H03731  2020.4 - 2023.3

科学研究費助成事業  基盤研究(B)

稲垣 暢也, 原田 範雄, 林 良敬, 山根 俊介

Glucagon-dependent autonomic regulatory system and its role in cardiovascular disease

Grant number：19H03651  2019.4 - 2022.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Regulation of nicotinamide metabolism by glucagon

Grant number：18H03176  2018.4 - 2023.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Analysis of the mechanisms of incretin secretion: similarities or differences of GIP and GLP-1 secretion

Grant number：16H05326  2016.4 - 2019.3

Inagaki Nobuya

Exploration of the role of glucagon in the crosstalk between glucose metabolism and amino acid metabolism

Grant number：15H04681  2015.4 - 2019.3

Hayashi Yoshitaka

Identification of a liver-derived factor that regulates proliferation of islet alpha cells

Grant number：15K15356  2015.4 - 2018.3

Hayashi Yoshitaka

Development of treatment and prevention for pancreatic neuroendocrine tumor using glucagon gene knock-out mouse

Grant number：15K10049  2015.4 - 2018.3

Kikumori Toyone

内分泌・代謝学セミナー

2019

自然環境と人間

2010

「自然環境と人間」

2009