Updated on 2023/10/13

写真a

 
SHIBATA, Takahiro
 
Organization
Graduate School of Bioagricultural Sciences Department of Applied Biosciences Professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences Department of Applied Biosciences
Title
Professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(農学) ( 2006.3   名古屋大学 ) 

Research Interests 5

  1. タンパク質科学

  2. 脂質生化学

  3. 食品機能化学

  4. 細胞外小胞

  5. 酸化ストレス

Research Areas 1

  1. Others / Others  / Food Science

Current Research Project and SDGs 5

  1. 炎症応答に関する研究

  2. 脂質メディエーターに関する研究

  3. 細胞外小胞を基軸とした疾患マーカーの探索

  4. タンパク質の酸化的修飾に関する研究

  5. 食品の機能性に関する研究

Research History 7

  1. Nagoya University   Professor

    2021.1

  2. Nagoya University   Institute of Innovation for Future Society

    2018.10

  3. Nagoya University   Associate professor

    2016.1 - 2020.12

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    Country:Japan

  4. JST さきがけ研究員

    2013.10 - 2017.3

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    Country:Japan

  5. Nagoya University   Assistant Professor

    2007.4 - 2015.12

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    Country:Japan

  6. Nagoya University   Assistant

    2007.1 - 2007.3

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    Country:Japan

  7. Doshisha University

    2006.4 - 2006.12

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    Country:Japan

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Education 3

  1. Nagoya University

    2003.4 - 2006.3

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    Country: Japan

  2. Nagoya University

    2001.4 - 2003.3

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    Country: Japan

  3. Nagoya University

    1997.4 - 2001.3

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    Country: Japan

Professional Memberships 4

  1. 日本生化学会

  2. 日本農芸化学会

  3. 日本酸化ストレス学会

  4. 日本細胞外小胞学会

Awards 2

  1. 農芸化学奨励賞

    2014.3   日本農芸化学会  

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    Country:Japan

  2. 日本酸化ストレス学会学術奨励賞

    2008.6   日本酸化ストレス学会  

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    Country:Japan

 

Papers 107

  1. Rapid Isolation of Extracellular Vesicles Using a Hydrophilic Porous Silica Gel-Based Size-Exclusion Chromatography Column Reviewed

    Yoshitake Jun, Azami Mayuko, Sei Haruka, Onoshima Daisuke, Takahashi Kumiko, Hirayama Akiyoshi, Uchida Koji, Baba Yoshinobu, Shibata Takahiro

    ANALYTICAL CHEMISTRY   Vol. 94 ( 40 ) page: 13676 - 13681   2022.9

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.analchem.2c01053

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  2. Eriodictyol and thymonin act as GPR35 agonists Reviewed International journal

    Nakashima Fumie, Loh Wei Qi, Wakabayashi Mayuka, Shimomura Sayako, Hattori Hiroyuki, Kita Masaki, Inoue Asuka, Uchida Koji, Shibata Takahiro

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY     2023.9

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bbb/zbad125

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  3. The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis Reviewed International coauthorship International journal

    Nakashima Fumie, Gimenez-Bastida Juan A., Luis Paula B., Presley Sai H., Boer Robert E., Chiusa Manuel, Shibata Takahiro, Sulikowski Gary A., Pozzi Ambra, Schneider Claus

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 299 ( 4 ) page: 103050   2023.4

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    DOI: 10.1016/j.jbc.2023.103050

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  4. Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis Reviewed International coauthorship International journal

    Okuda Kosaku, Nakahara Kengo, Ito Akihiro, Iijima Yuta, Nomura Ryosuke, Kumar Ashutosh, Fujikawa Kana, Adachi Kazuya, Shimada Yuki, Fujio Satoshi, Yamamoto Reina, Takasugi Nobumasa, Onuma Kunishige, Osaki Mitsuhiko, Okada Futoshi, Ukegawa Taichi, Takeuchi Yasuo, Yasui Norihisa, Yamashita Atsuko, Marusawa Hiroyuki, Matsushita Yosuke, Katagiri Toyomasa, Shibata Takahiro, Uchida Koji, Niu Sheng-Yong, Lang Nhi B., Nakamura Tomohiro, Zhang Kam Y. J., Lipton Stuart A., Uehara Takashi

    NATURE COMMUNICATIONS   Vol. 14 ( 1 ) page: 621   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-023-36232-6

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  5. Neuritogenic steroid glycosides from crown-of-thorns starfish: Possible involvement of p38 mitogen-activated protein kinase and attenuation of cognitive impairment in senescence-accelerated mice (SAMP8) by peripheral administration Reviewed International coauthorship International journal

    Sasayama Yumi, Mamiya Takayoshi, Qi Jianhua, Shibata Takahiro, Uchida Koji, Nabeshima Toshitaka, Ojika Makoto

    BIOORGANIC & MEDICINAL CHEMISTRY   Vol. 78   page: 117144   2023.1

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    DOI: 10.1016/j.bmc.2022.117144

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  6. Metabolomics of small extracellular vesicles derived from isocitrate dehydrogenase 1-mutant HCT116 cells collected by semi-automated size exclusion chromatography Invited Reviewed International journal

    Hayasaka Ryosuke, Tabata Sho, Hasebe Masako, Ikeda Satsuki, Hikita Tomoya, Oneyama Chitose, Yoshitake Jun, Onoshima Daisuke, Takahashi Kumiko, Shibata Takahiro, Uchida Koji, Baba Yoshinobu, Soga Tomoyoshi, Tomita Masaru, Hirayama Akiyoshi

    FRONTIERS IN MOLECULAR BIOSCIENCES   Vol. 9   page: 1049402   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fmolb.2022.1049402

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  7. Molecular networking-based lipid profiling and multi-omics approaches reveal new contributions of functional vanilloids to gut microbiota and lipometabolism changes Reviewed International journal

    Hattori Hiroyuki, Moriyama Akihiro, Ohno Tomoki, Shibata Takahiro, Iwahashi Hitoshi, Mitsunaga Tohru

    FOOD CHEMISTRY: MOLECULAR SCIENCES   Vol. 5   page: 100123   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.fochms.2022.100123

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  8. Autoxidation of ascorbate mediates lysine N-pyrrolation Reviewed International journal

    Yoshitake Jun, Shibata Takahiro, Chikazawa Miho, Uchida Koji

    FREE RADICAL RESEARCH   Vol. 56 ( 11-12 ) page: 749 - 759   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/10715762.2023.2174865

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  9. Histone functions as a cell-surface receptor for AGEs Reviewed

    Itakura Masanori, Yamaguchi Kosuke, Kitazawa Roma, Lim Sei-Young, Anan Yusuke, Yoshitake Jun, Shibata Takahiro, Negishi Lumi, Sugawa Hikari, Nagai Ryoji, Uchida Koji

    NATURE COMMUNICATIONS   Vol. 13 ( 1 ) page: 2974   2022.5

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    DOI: 10.1038/s41467-022-30626-8

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  10. Redox-dependent internalization of the purinergic P2Y(6) receptor limits colitis progression Reviewed International coauthorship

    Nishiyama Kazuhiro, Nishimura Akiyuki, Shimoda Kakeru, Tanaka Tomohiro, Kato Yuri, Shibata Takahiro, Tanaka Hiroshi, Kurose Hitoshi, Azuma Yasu-Taka, Ihara Hideshi, Kumagai Yoshito, Akaike Takaaki, Eaton Philip, Uchida Koji, Nishida Motohiro

    SCIENCE SIGNALING   Vol. 15 ( 716 ) page: eabj0644   2022.1

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    DOI: 10.1126/scisignal.abj0644

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  11. Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution Reviewed

    Kinoshita Remi, Kozaki Ikko, Shimizu Kazunori, Shibata Takahiro, Ochiai Akihito, Honda Hiroyuki

    ACS OMEGA   Vol. 6 ( 46 ) page: 31244 - 31252   2021.11

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  12. Low-molecular-weight whey proteins promote collagen production in dermal fibroblasts via the TGF-beta receptor/Smad pathway Reviewed

    Katayoshi Takeshi, Kusano Yuri, Shibata Takahiro, Uchida Koji, Tsuji-Naito Kentaro

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 85 ( 11 ) page: 2232 - 2240   2021.11

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  13. Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified Reviewed

    Tanaka Hiromasa, Hosoi Yugo, Ishikawa Kenji, Yoshitake Jun, Shibata Takahiro, Uchida Koji, Hashizume Hiroshi, Mizuno Masaaki, Okazaki Yasumasa, Toyokuni Shinya, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 18488   2021.9

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  14. Oxidative deamination of lysine residues by polyphenols generates an equilibrium of aldehyde and 2-piperidinol products Reviewed

    Yamaguchi Kosuke, Itakura Masanori, Kitazawa Roma, Lim Sei-Young, Nagata Koji, Shibata Takahiro, Akagawa Mitsugu, Uchida Koji

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 297 ( 3 ) page: 101035   2021.9

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  15. 6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise Reviewed International journal

    Hattori Hiroyuki, Mori Takashi, Shibata Takahiro, Kita Masaki, Mitsunaga Tohru

    MOLECULAR NUTRITION & FOOD RESEARCH   Vol. 65 ( 16 ) page: e2100185   2021.8

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    DOI: 10.1002/mnfr.202100185

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  16. Identification of biosynthetic intermediates for the mating hormone alpha 2 of the plant pathogen Phytophthora Reviewed

    Ariyoshi Suguru, Imazu Yusuke, Ohguri Ryuji, Katsuta Ryo, Yajima Arata, Shibata Takahiro, Ojika Makoto

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 85 ( 8 ) page: 1802 - 1808   2021.7

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  17. Sodium sulfite causes gastric mucosal cell death by inducing oxidative stress Reviewed

    Oshimo Moeri, Nakashima Fumie, Kai Kenji, Matsui Hirofumi, Shibata Takahiro, Akagawa Mitsugu

    FREE RADICAL RESEARCH   Vol. 55 ( 6 ) page: 731 - 743   2021.6

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  18. Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution Reviewed

    Yoshioka Keitaro, Yamashita Haruki, Shimizu Kazunori, Shimomura Sayako, Shibata Takahiro, Miyazaki Jun-ichi, Honda Hiroyuki

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 550   page: 177 - 183   2021.4

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  19. Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor

    Hasegawa Kana, Kuwata Keiko, Yoshitake Jun, Shimomura Sayako, Uchida Koji, Shibata Takahiro

    FEBS JOURNAL   Vol. 288 ( 6 ) page: 1906 - 1917   2021.3

  20. Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution. Invited Reviewed

    Yoshioka K, Yamashita H, Shimizu K, Shimomura S, Shibata T, Miyazaki JI, Honda H.

    Biochem. Biophys. Res. Commun.   Vol. 550   page: 177 - 183   2021

  21. PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates

    Kamata Shotaro, Oyama Takuji, Saito Kenta, Honda Akihiro, Yamamoto Yume, Suda Keisuke, Ishikawa Ryo, Itoh Toshimasa, Watanabe Yasuo, Shibata Takahiro, Uchida Koji, Suematsu Makoto, Ishii Isao

    ISCIENCE   Vol. 23 ( 11 ) page: 101727   2020.11

  22. Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D

    Takamiya Rina, Takahashi Motoko, Maeno Toshitaka, Saito Atsushi, Kato Masaki, Shibata Takahiro, Uchida Koji, Ariki Shigeru, Nakano Miyako

    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS   Vol. 1864 ( 11 ) page: 129699   2020.11

  23. Acyl-CoA dehydrogenase long chain (ACADL) is a target protein of stylissatin A, an anti-inflammatory cyclic heptapeptide

    Zhang Menghua, Sunaba Taiki, Sun Yiting, Shibata Takahiro, Sasaki Kazunori, Isoda Hiroko, Kigoshi Hideo, Kita Masaki

    JOURNAL OF ANTIBIOTICS   Vol. 73 ( 8 ) page: 589 - 592   2020.8

  24. Isolation and structure-activity relationship studies of jacaranones: Anti-inflammatory quinoids from the Cuban endemic plant Jacaranda arborea (Bignoniaceae)

    Hirukawa Minako, Zhang Menghua, Echenique-Diaz Lazaro M., Mizota Koji, Ohdachi Satoshi D., Begue-Quiala Gerardo, Delgado-Labanino Jorge L., Gamez-Diez Jorgelino, Alvarez-Lemus Jose, Galano Machado Leandro, Suarez Nunez Miguel, Shibata Takahiro, Kigoshi Hideo, Kita Masaki

    Tetrahedron Letters   Vol. 61 ( 26 )   2020.6

  25. Glycolaldehyde is an endogenous source of lysine N-pyrrolation

    Chikazawa Miho, Yoshitake Jun, Lim Sei-Young, Iwata Shiori, Negishi Lumi, Shibata Takahiro, Uchida Koji

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 295 ( 22 ) page: 7697 - 7709   2020.5

  26. Quantitative analysis of oxidized vitamin B1 metabolites generated by hypochlorous acid

    Sasatsuki Hitoshi, Nakazaki Atsuo, Uchida Koji, Shibata Takahiro

    FREE RADICAL BIOLOGY AND MEDICINE   Vol. 152   page: 197 - 206   2020.5

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  27. Relationship among structure, cytotoxicity, and Michael acceptor reactivity of quinocidin

    Nakagawa Yu, Sawaki Yuki, Miyanishi Wataru, Shimomura Sayako, Shibata Takahiro, Ojika Makoto

    BIOORGANIC & MEDICINAL CHEMISTRY   Vol. 28 ( 4 ) page: 115308   2020.2

  28. A unique mechanism for thiolation of serum albumins by disulphide molecules

    Nakashima Fumie, Shibata Takahiro, Uchida Koji

    JOURNAL OF BIOCHEMISTRY   Vol. 167 ( 2 ) page: 165 - 171   2020.2

  29. Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B

    Nho Cong Luong, Abiko Yumi, Shibata Takahiro, Uchida Koji, Warabi Eiji, Suzuki Midori, Noguchi Takuya, Matsuzawa Atsushi, Kumagai Yoshito

    JOURNAL OF TOXICOLOGICAL SCIENCES   Vol. 45 ( 6 ) page: 349 - 363   2020

  30. Protein adductomics: A comprehensive analysis of protein modifications by electrophiles.

    Shibata T, Uchida K

    Free radical biology & medicine   Vol. 144   page: 218 - 222   2019.11

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    DOI: 10.1016/j.freeradbiomed.2019.02.034

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  31. Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal(ONE) in preeclamptic placentas. Reviewed International coauthorship International journal

    Free radical biology & medicine   Vol. 141   page: 416 - 425   2019.9

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    DOI: 10.1016/j.freeradbiomed.2019.07.015

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  32. A Dual Perspective of the Action of Lysine on Soybean Oil Oxidation Process Obtained by Combining <sup>1</sup>H NMR and LC-MS: Antioxidant Effect and Generation of Lysine-Aldehyde Adducts. Reviewed International coauthorship International journal

    Antioxidants (Basel, Switzerland)   Vol. 8 ( 9 )   2019.9

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    DOI: 10.3390/antiox8090326

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  33. Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

    Suzuki Takafumi, Muramatsu Aki, Saito Ryota, Iso Tatsuro, Shibata Takahiro, Kuwata Keiko, Kawaguchi Shin-ichi, Iwawaki Takao, Adachi Saki, Suda Hiromi, Morita Masanobu, Uchida Koji, Baird Liam, Yamamoto Masayuki

    CELL REPORTS   Vol. 28 ( 3 ) page: 746 - +   2019.7

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    DOI: 10.1016/j.celrep.2019.06.047

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  34. Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins

    Hirose Sayumi, Hioki Yusuke, Miyashita Hiroaki, Hirade Naoya, Yoshitake Jun, Shibata Takahiro, Kikuchi Ryosuke, Matsushita Tadashi, Chikazawa Miho, Itakura Masanori, Zhang Mimin, Nagata Koji, Uchida Koji

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 294 ( 28 ) page: 11035 - 11045   2019.7

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    DOI: 10.1074/jbc.RA118.006629

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  35. 2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct. Reviewed International journal

    Yoshitake J, Shibata T, Shimayama C, Uchida K

    Redox biology   Vol. 23   page: 101115   2019.5

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    DOI: 10.1016/j.redox.2019.101115

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  36. 2-Oxo-histidine-containing dipeptides are functional oxidation products

    Ihara Hideshi, Kakihana Yuki, Yamakage Akane, Kai Kenji, Shibata Takahiro, Nishida Motohiro, Yamada Ken-ichi, Uchida Koji

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 294 ( 4 ) page: 1279-1289   2019.1

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    DOI: 10.1074/jbc.RA118.006111

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  37. Diosgenin Supplementation Prevents Lipid Accumulation and Induces Skeletal Muscle-Fiber Hypertrophy in Rats

    Kusano Yuri, Tsujihara Nobuko, Masui Hironori, Shibata Takahiro, Uchida Koji, Takeuchi Wakako

    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY   Vol. 65 ( 5 ) page: 421 - 429   2019

  38. Development of a novel monoclonal antibody against 4-hydroxy-2E,6Z-dodecadienal (4-HDDE)-protein adducts: Immunochemical application in quantitative and qualitative analyses of lipid peroxidation in vitro and ex vivo

    Uchida Koji, Shibata Takahiro, Toyokuni Shinya, Daniel Bareket, Zarkovic Kamelija, Zarkovic Neven, Sasson Shlomo

    FREE RADICAL BIOLOGY AND MEDICINE   Vol. 124   page: 12-20   2018.8

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    DOI: 10.1016/j.freeradbiomed.2018.05.079

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  39. Structural and functional insights into S-thiolation of human serum albumins

    Nakashima Fumie, Shibata Takahiro, Kamiya Kohei, Yoshitake Jun, Kikuchi Ryosuke, Matsushita Tadashi, Ishii Isao, Gimenez-Bastida Juan A., Schneider Claus, Uchida Koji

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 932   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-19610-9

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  40. Detection and quantification of 2-oxo-histidine-containing dipeptides

    Ihara Hideshi, Kakihana Yuki, Yamakage Akane, Shibata Takahiro, Uchida Koji

    FREE RADICAL BIOLOGY AND MEDICINE   Vol. 112   page: 26 - 27   2017.11

  41. Lipid radicals cause light-induced retinal degeneration Reviewed International journal

    Enoki Masataka, Shinto Saki, Matsuoka Yuta, Otsuka Ayasa, Kaidzu Sachiko, Tanito Masaki, Shibata Takahiro, Uchida Koji, Ohira Akihiro, Yamatoa Mayumi, Yamada Ken-ichi

    CHEMICAL COMMUNICATIONS   Vol. 53 ( 79 ) page: 10922 - 10925   2017.10

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    DOI: 10.1039/c7cc03387g

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  42. Identification of Polyphenol-Specific Innate Epitopes That Originated from a Resveratrol Analogue

    Furuhashi Mai, Hatasa Yukinori, Kawarnura Sae, Shibata Takahiro, Akagawa Mitsugu, Uchida Koji

    BIOCHEMISTRY   Vol. 56 ( 35 ) page: 4701-4712   2017.9

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    DOI: 10.1021/acs.biochem.7b00409

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  43. De Novo Synthesis of Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor

    Nakazaki Atsuo, Hashimoto Keiko, Ikeda Ai, Shibata Takahiro, Nishikawa Toshio

    JOURNAL OF ORGANIC CHEMISTRY   Vol. 82 ( 17 ) page: 9097-9111   2017.9

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    DOI: 10.1021/acs.joc.7b01640

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  44. Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke

    Takamiya Rina, Uchida Koji, Shibata Takahiro, Maeno Toshitaka, Kato Masaki, Yamaguchi Yoshiki, Ariki Shigeru, Hasegawa Yoshihiro, Saito Atsushi, Miwa Soichi, Takahashi Hiroki, Akaike Takaaki, Kuroki Yoshio, Takahashi Motoko

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 8304   2017.8

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    DOI: 10.1038/s41598-017-08588-5

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  45. Adductome-based identification of biomarkers for lipid peroxidation

    Shibata Takahiro, Shimizu Kazuma, Hirano Keita, Nakashima Fumie, Kikuchi Ryosuke, Matsushita Tadashi, Uchida Koji

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 292 ( 20 ) page: 8223-8235   2017.5

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    DOI: 10.1074/jbc.M116.762609

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  46. Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes

    Luis Paula B., Gordon Odaine N., Nakashima Fumie, Joseph Akil I., Shibata Takahiro, Uchida Koji, Schneider Claus

    BIOCHEMICAL PHARMACOLOGY   Vol. 132   page: 143-149   2017.5

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    DOI: 10.1016/j.bcp.2017.03.002

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  47. Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E-2 and D-2 by activated human leukocytes

    Gimenez-Bastida Juan A., Shibata Takahiro, Uchida Koji, Schneider Claus

    FASEB JOURNAL   Vol. 31 ( 5 ) page: 1867-1878   2017.5

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    DOI: 10.1096/fj.201601136R

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  48. An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E),11(E)-octadecadienoic acid Reviewed International coauthorship

    Dong Jinhua, Shichiri Mototada, Chung Chan-I., Shibata Takahiro, Uchida Koji, Hagihara Yoshihisa, Yoshida Yasukazu, Ueda Hiroshi

    ANALYST   Vol. 142 ( 5 ) page: 787 - 793   2017.3

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    DOI: 10.1039/c6an02437h

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  49. Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein

    Kuan Yen-Chou, Hashidume Tsutomu, Shibata Takahiro, Uchida Koji, Shimizu Makoto, Inoue Jun, Sato Ryuichiro

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 292 ( 7 ) page: 3016-3028   2017.2

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    DOI: 10.1074/jbc.M116.767277

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  50. Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes. Reviewed

    Giménez-Bastida, J.A., Shibata, T., Uchida, K., & Schneider, C.

    FASEB J.   Vol. 32   page: 1867-1878   2017

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  51. Identification of C1q as a Binding Protein for Advanced Glycation End Products. Reviewed

    Chikazawa, M., Shibata, T., Hatasa, Y., Hirose, S., Otaki, N., Nakashima, F., Ito, M., Machida, S., Maruyama, S., & Uchida, K.

      Vol. 55   page: 435-446   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

  52. Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein. Reviewed

    Akagawa, M., Minematsu, K., Shibata, T., Kondo, T., Ishii, T., & Uchida K.

    Sci Rep.   Vol. 6   page: 26723   2016

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  53. Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-Gallate: A Potential Mechanism for the Formation of Innate Antigens by Antioxidants Reviewed

    PLoS One.   Vol. 11   page: e0153002   2016

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  54. Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. Reviewed

    Shibata, T., Takahashi, K., Matsubara, Y., Inuzuka, E., Nakashima, F., Takahashi, N., Kozai, D., Mori, Y., & Uchida, K.

    Sci. Rep.   Vol. 6   page: 21261   2016

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  55. Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile. Reviewed

    Kumagai, T., Usami, H., Matsukawa, N., Nakashima, F., Chikazawa, M., Shibata, T., Noguchi, N., and Uchida, K.

    Redox Biol.   Vol. 4   page: 74-86   2015

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  56. 15-Deoxy-Δ12,14-prostaglandin J2 as an electrophilic mediator. Invited Reviewed

    Shibata, T.

    Biosci. Biotechnol. Biochem.   Vol. 79   page: 1044-1049   2015

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  57. Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins. Reviewed

    Miyashita, H., Chikazawa, M., Otaki, N., Hioki, Y., Shimozu, Y., Nakashima, F., Shibata, T., Hagihara, Y., Maruyama, S., Matsumi, N., Uchida, K. (2014)

    Sci. Rep.   Vol. 4   page: 5343   2014

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  58. Toll-like receptors as a target of food-derived anti-inflammatory compounds. Reviewed

    Shibata, T., Nakashima, F., Honda, K., Lu, Y.J., Kondo, T., Ushida, Y., Aizawa, K., Suganuma, H., Oe, S., Tanaka, H., Takahashi, T., and Uchida, K.

    J. Biol. Chem.   Vol. 289   page: 32757-32772.   2014

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  59. Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigens. Reviewed

    1. Chikazawa, M., Otaki, N., Shibata, T., Miyashita, H., Kawai, Y., Maruyama, S., Toyokuni, S., Kitaura, Y., Matsuda, T., and Uchida, K.

    J. Biol. Chem.   Vol. 288   page: 13204-13214   2013

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  60. An apoptosis-associated mammary protein deficiency leads to enhanced production of IgM antibodies against multiple damage-associated molecules. Reviewed

    Chikazawa, M., Otaki, N., Shibata, T., Yasueda, T., Matsuda, T., and Uchida, K.

    PLoS One   Vol. 8   page: e68468.   2013

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  61. Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. Reviewed

    5. Kumano-Kuramochi, M., Shimozu, Y., Wakita, C., Ohnishi-Kameyama, M., Shibata, T., Matsunaga, S., Takano-Ishikawa, Y., Watanabe, J., Goto, M., Xie, Q., Komba, S., Uchida, K., and Machida, S

    Biochem. J.   Vol. 442   page: 171-180   2012.2

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  62. Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. Reviewed

    Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.

      Vol. 8   page: 714- 724   2012

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  63. Quantitative Analysis of Acrolein-Specific Adducts Generated during Lipid Peroxidation-Modification of Proteins in Vitro. Reviewed

      Vol. 25   page: 1384-1392   2012

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  64. Monoclonal Antibody against Protein-Bound Glutathione: Use of Glutathione Conjugate of Acrolein-Modified Proteins as an Immunogen. Reviewed

    Chem. Res. Toxicol.   Vol. 25   page: 1393-1401   2012

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  65. Constitutive expression of an antioxidant enzyme, glutathione S-transferase P1, during differentiation of human intestinal Caco-2 cells. Reviewed

    Kusano Y, Horie S, Morishita N, Shibata T, Uchida K.

    Free Radic. Biol. Med.   Vol. 53   page: 347-356   2012

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  66. Transthiocarbamoylation of proteins by thiolated isothiocyanates Reviewed

    Shibata, T., Kimura, Y., Mukai, A., Mori, H., Ito, S., Asaka, Y., Oe, S., Tanaka, H., Takahashi, T., and Uchida, K.

    J. Biol. Chem.     page: in press   2011

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  67. 4-Hydroperoxy-2-nonenal is not just an intermediate, but a reactive molecule that covalently modifies proteins to generate unique intramolecular oxidation products. Reviewed

    Shimozu, Y., Hirano, K., Shibata, T., Shibata, N., and Uchida, K.

    J. Biol. Chem.   Vol. 286   page: 29313-29324.   2011

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  68. Lipid peroxidation modification of protein generates Nepsilon-(4-oxononanoyl)lysine as a pro-inflammatory ligand. . Reviewed

    Shibata, T., Shimozu, Y., Wakita, C., Shibata, N., Kobayashi, M., Machida, S., Kato, R., Itabe, H., Zhu, X., Sayre, L. M., and Uchida, K.

    J. Biol. Chem   Vol. 286   page: 19943-19957.   2011

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  69. A method for detection of 4-hydroxy-2-nonenal adducts in proteins. Reviewed

    Wakita, C., Honda, K., Shibata, T., Akagawa, M., and Uchida, K.

    Free Radic. Biol. Med.   Vol. 51   page: 1-4   2011

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  70. Delta12-Prostaglandin J2 as a Product and Ligand of Human Serum Albumin: Formation of an Unusual Covalent Adduct at His146. Reviewed

    Yamaguchi, S., Aldini, G., Ito, S., Morishita, N., Shibata, T., Vistoli, G., Carini, M., Uchida, K.

    J. Am. Chem. Soc.   Vol. 132   page: 824-832   2010

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  71. Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies. Reviewed

    Otaki, N., Chikazawa, M., Nagae, R., Shimozu, Y., Shibata, T., Ito, S., Takasaki, Y., Fujii, J., and Uchida K.

    J. Biol. Chem.   Vol. 285   page: 33834-33842   2010

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  72. Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. Reviewed

    Nishida, M., Suda, R., Nagamatsu, Y., Tanabe, S., Onohara, N., Nakaya, M., Kanaho, Y., Shibata, T., Uchida, K., Sumimoto, H., Sato, Y., Kurose, H.

    J. Biol. Chem.   Vol. 285   page: 15268-15277   2010

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  73. Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. Reviewed

    Ishino, K., Wakita, C., Shibata, T., Toyokuni, S., Machida, S., Matsuda, S., Matsuda, T., Uchida, K.

    J. Biol. Chem.   Vol. 285   page: 15302-15313   2010

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  74. Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-delta12,14-prostaglandin J2. Reviewed

    Zhang, H.X., Tanji, K., Yoshida, H., Hayakari, M., Shibata, T., Mori, F., Uchida, K., Wakabayashi, K.

    Exp. Neurol.   Vol. 222   page: 296-303   2010

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  75. Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. Reviewed

    J. Biol. Chem.   ( 285 ) page: 15302-15313   2010

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  76. Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy- delta12,14-prostaglandin J2. Reviewed

    30) Zhang, H.X., Tanji, K., Yoshida, H., Hayakari, M., Shibata, T., Mori, F., Uchida, K., Wakabayashi, K.

    Exp. Neurol.   Vol. 222   page: 296-303   2010

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  77. Identification of advanced reaction products originating from the initial 4-oxo-2-nonenal-cysteine Michael adducts. Reviewed

    Shimozu, Y., Shibata, T., Ojika, M., Uchida, K.

    Chem. Res. Toxicol.   Vol. 22   page: 957-964   2009

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  78. Immunohistochemical Detection of 13(R)-hydroxyoctadecadienoic Acid in Atherosclerotic Plaques of Human Carotid Arteries Using a Novel Specific Antibody. Reviewed

    Shibata N, Toi S, Shibata T, Uchida K, Itabe H, Sawada T, Kawamata T, Okada Y, Uchiyama S, Kobayashi M.

    Acta Histochem. Cytochem.   Vol. 42   page: 197-203   2009

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  79. Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein. Reviewed

    Wakita, C., Maeshima, T., Yamazaki, A., Shibata, T., Ito, S., Akagawa, M., Ojika, M., Yodoi, J., Uchida, K.

    J. Biol. Chem.   Vol. 284   page: 28810-28822   2009

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  80. 15-Deoxy-Delta(12,14)-prostaglandin J2: An Electrophilic Trigger of Cellular Responses. Invited Reviewed

    Uchida, K., & Shibata, T.

    Chem. Res. Toxicol. 138-144.   Vol. 21   page: 138-144   2008.1

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  81. Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells. Reviewed

    21) Kusano, Y., Horie, S., Shibata, T., Satsu, H., Shimizu, M., Hitomi, E., Nishida, M., Kurose, H., Itoh, K., Kobayashi, A., Yamamoto, M., and Uchida, K.

    Biochemistry   Vol. 47   page: 6169-6177   2008

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  82. *A food-derived synergist of NGF signaling: Identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction. Reviewed

    Shibata T, Nakahara H, Kita N, Matsubara Y, Han C, Morimitsu Y, Iwamoto N, Kumagai Y, Nishida M, Kurose H, Aoki N, Ojika M, Uchida K.

    J. Neurochem.   Vol. 107 ( 5 ) page: 1248-1260   2008

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  83. Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Reviewed

    Takahashi, N., Mizuno, Y., Kozai, D., Yamamoto, S., Kiyonaka, S., Shibata, T., Uchida, K., and Mori, Y.

    Channels (Austin)   Vol. 2   page: 287-298   2008

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  84. Protein N-Acylation: H2O2-Mediated Covalent Modification of Protein by Lipid Peroxidation-Derived Saturated Aldehydes. Reviewed

    Ishino, K., Shibata, T., Ishii, T., Liu, Y. T., Toyokuni, S., Zhu, X., Sayre, L. M., and Uchida, K.

    Chem. Res. Toxicol.   Vol. 21   page: 1261-1270   2008

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  85. Identification of a Serum Component That Regulates Cyclooxygenase-2 Gene Expression in Cooperation with 4-Hydroxy-2-nonenal. Reviewed

    Kanayama M, Yamaguchi S, Shibata T, Shibata N, Kobayashi M, Nagai R, Arai H, Takahashi K, Uchida K.

    J. Biol. Chem.   Vol. 282 ( 33 ) page: 24166-24174   2007.8

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  86. Granulatoside A, a Starfish Steroid Glycoside, Enhances PC12 Cell Neuritogenesis Induced by Nerve Growth Factor through an Activation of MAP Kinase. Reviewed

    Qi J, Han C, Sasayama Y, Nakahara H, Shibata T, Uchida K, Ojika M.

    ChemMedChem.   Vol. 1   page: 1351-4   2007

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  87. Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. Reviewed

    Mizutani, N., Sakurai, T., Shibata, T., Uchida, K., Fujita, J., Kawashima, R., Kawamura, Y. I., Toyama-Sorimachi, N., Imai, T., & Dohi, T.

    J. Immunol.   Vol. 179   page: 7478-87   2007

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  88. Protein-bound 4-Hydroxy-2-nonenal: AN ENDOGENOUS TRIGGERING ANTIGEN OF ANTI-DNA RESPONSE. Reviewed

    Toyoda K, Nagae R, Akagawa M, Ishino K, Shibata T, Ito S, Shibata N, Yamamoto T, Kobayashi M, Takasaki Y, Matsuda T, Uchida K.

    J. Biol. Chem.   Vol. 282 ( 35 ) page: 25769-25778   2007

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  89. Identification of Actin as a 15-Deoxy-Delta(12,14)-prostaglandin J(2) Target in Neuroblastoma Cells: Mass Spectrometric, Computational, and Functional Approaches To Investigate the Effect on Cytoskeletal Derangement. Reviewed

    Aldini G, Carini M, Vistoli G, Shibata T, Kusano Y, Gamberoni L, Dalle-Donne I, Milzani A, Uchida K.

    Biochemistry   Vol. 46 ( 10 ) page: 2707-2718   2007

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  90. Polymer-Assisted Solution-Phase Synthesis and Neurite-Outgrowth-Promoting Activity of 15-Deoxy- 12,14-PGJ2 Derivatives Reviewed

    Tanaka H, Hasegawa T, Kita N, Nakahara H, Shibata T, Oe S, Ojika M, Uchida K, and Takahashi T.

    Chemistry-An Asian Journal   Vol. 1   page: 669-677   2007

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  91. ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. Reviewed

    Kobayashi M, Ono H, Mihara K, Tauchi H, Komatsu K, Shibata T, Shimizu H, Uchida K, Yamamoto K.

    Genes Cells   Vol. 11 ( 7 ) page: 779-789   2006.7

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  92. Prostaglandins from a zoanthid: Paclitaxel-like neurite-degenerating and microtubule-stabilizating activities. Reviewed

    Han C, Qi J, Shi X, Sakagami Y, Shibata T, Uchida K, & Ojika M.

    Biosci. Biotechnol. Biochem.   Vol. 70   page: 706-11   2006.3

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  93. Bispecific abs against modified protein and DNA with oxidized lipids. Reviewed

    Akagawa M, Ito S, Toyoda K, Ishii Y, Tatsuda E, Shibata T, Yamaguchi S, Kawai Y, Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K.

    Proc. Natl. Acad. Sci. USA   Vol. 103   page: 6160-5   2006

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  94. Ebselen, a Seleno-organic Antioxidant, as an Electrophile Reviewed

    Sakurai, T., Kanayama, M., Shibata, T., Itoh, K., Kobayashi, A., Yamamoto, M., & Uchida, K.

    Chem. Res. Toxicol.   Vol. 19   page: 1196-204   2006

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  95. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Reviewed

    Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M.

    Mol. Cell. Biol.   Vol. 26 ( 1 ) page: 221-229   2006

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  96. Metal-catalyzed oxidation of protein-bound dopamine. Reviewed

    Akagawa M, Ishii Y, Ishii T, Shibata T, Yotsu-Yamashita M, Suyama K, Uchida K.

    Biochemistry   Vol. 45 ( 50 ) page: 15120-8   2006

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  97. *Identification of a lipid peroxidation product as a potential trigger of the p53 pathway. Reviewed

    Shibata T, Iio K, Kawai Y, Shibata N, Kawaguchi M, Toi S, Kobayashi M, Kobayashi M, Yamamoto K, & Uchida K.

    J. Biol. Chem.   Vol. 281   page: 1196-1204   2005

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  98. Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. Reviewed

    Hosoya T, Maruyama A, Kang MI, Kawatani Y, Shibata T, Uchida K, Itoh K, & Yamamoto M.

    J. Biol. Chem.   Vol. 280   page: 27244-27250   2005

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  99. 「プロスタグランジンJ2の化学と生物 -多様な生理活性とその分子過程-」

    柴田貴広、内田浩二

    日本農芸化学会誌 「化学と生物」   Vol. 43 ( 1 ) page: 20-27   2005

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  100. 「J2型プロスタグランジン研究の現状」

    柴田貴広、内田浩二

    日本生化学会誌「生化学」   Vol. 77   page: 1189-1192   2005

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  101. 「野菜由来イソチオシアネートによる神経細胞分化誘導」

    柴田貴広、中原寛子、内田浩二

    食品工業   Vol. 48   page: 63-67   2005

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  102. Transcription Factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-delta12,14-prostaglandin J2. Reviewed

    Itoh K, Mochizuki M, Ishii Y, Ishii T, Shibata T, Kawamoto Y, Kelly V, Sekizawa K, Uchida K, & Yamamoto M.

    Mol. Cell. Biol.   Vol. 24   page: 36-45   2004

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  103. Structural basis of protein-bound endogenous aldehydes : Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct. Reviewed

    Hashimoto M, Shibata T, Wasada H, Toyokuni S, & Uchida K.

    J. Biol. Chem   Vol. 278   page: 5044-51   2003

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  104. An endogenous electrophile that modulates the regulatory mechanism of protein turnover. Reviewed

    Biochemistry   Vol. 42   page: 13960-13968   2003

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  105. Thioredoxin as a molecular target of cyclopentenone prostaglandins. Reviewed

    Shibata T, Yamada T, Ishii T, Kumazawa S, Nakamura H, Masutani H, Yodoi J, & Uchida K

    J. Biol.Chem   Vol. 278   page: 26046-54   2003

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  106. 15-Deoxy-delta12,14-prostaglandin J2: The endogenous electrophile that induces neuronal apoptosis Reviewed

    Kondo M, Shibata T, Kumagai T, Osawa T, Shibata N, Kobayashi M, Sasaki S, Iwata M, Noguchi N, and Uchida K.

    Proc. Natl. Acad. Sci. USA   Vol. 99 ( 11 ) page: 7367-7372   2002

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  107. 15-Deoxy-delta12,14-prostaglandin J2: A PROSTAGLANDIN D2 METABOLITE GENERATED DURING INFLAMMATORY PROCESSES Reviewed

    Shibata T, Kondo M, Osawa T, Shibata N, Kobayashi M, & Uchida K.

    J. Biol. Chem.   Vol. 277 ( 12 ) page: 10459-10466   2002

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▼display all

MISC 2

  1. 細胞膜受容体の活性制御を介した食品成分の機能性

    柴田貴広

    実験医学増刊「食と健康を結ぶメディカルサイエンス」     page: 162 - 166   2020

  2. システイン残基におけるユニークな自然修飾

    中島史恵、柴田貴広、内田浩二

    実験医学増刊「食と健康を結ぶメディカルサイエンス」     page: 52 - 58   2020

Presentations 17

  1. 細胞膜受容体を介した食品成分の機能性 Invited

    柴田貴広

    第35回日本香辛料研究会  2021.12 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京(オンライン)  

  2. 脂質に由来する親電子性活性種によるタンパク質の化学修飾 Invited

    柴田貴広

    第67回トキシンシンポジウム  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋(オンライン)  

  3. 酸化リポタンパク質のアダクトーム解析 Invited

    柴田貴広、内田浩二

    第81回分析化学討論会  2021.7 

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    Event date: 2021.7

    Presentation type:Symposium, workshop panel (public)  

    Venue:仙台(オンライン)  

  4. 健康維持に役立つ食の機能の理解と利用 Invited

    柴田貴広

    産学連携学会第19回大会  2021.6 

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    Event date: 2021.6

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:名古屋(オンライン)  

  5. レドックスアダクトーム:親電子性化合物によるタンパク質修飾の包括的解析

    柴田貴広

    第47回日本毒性学会学術年会シンポジウム  2020.7 

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    Presentation type:Symposium, workshop panel (nominated)  

  6. タンパク質化学修飾を基軸とした疾患マーカーの開発 Invited

    柴田貴広

    バイオインダストリー協会4大学医工連携セミナー  2021.2 

  7. 香辛料Grains of Paradise成分の抗肥満活性と作用メカニズムの解明

    服部浩之、柴田貴広、光永徹

    第72回日本木材学会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  8. Pyrroloquinoline quinoneにより活性化されるGタンパク質共役型受容体の同定

    6. 金森 星、若林万由香、下村沙也子、服部浩之、赤川 貢、井上飛鳥、内田浩二、柴田貴広

    日本農芸化学会2022年度大会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  9. アントシアニジンによる代謝物感受性受容体GPR35の活性化

    下村沙也子、服部浩之、若林万由香、DIDIK HUSWO Utomo、北 将樹、井上飛鳥、内田浩二、柴田貴広

    日本農芸化学会2022年度大会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  10. アスコルビン酸酸化に起因するタンパク質ピロール化

    吉武淳、柴田貴広、近澤未歩、内田浩二

    日本農芸化学会2022年度大会  2022.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  11. 低密度リポタンパク質における酸化リン脂質修飾構造の網羅的解析

    大塚優人、青山拓生、内田浩二、柴田貴広

    第94回日本生化学会大会  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  12. アントシアニジンにより活性化されるGタンパク質共役型受容体の同定

    下村沙也子、服部浩之、若林万由香、井上飛鳥、内田浩二、柴田貴広

    日本ポリフェノール学会第14回学術集会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  13. 抗炎症性プロスタグランジンは血清存在下において炎症促進に作用する

    柴田貴広, 山口悟, 森下望美, 河合慶親, 柴田亮行, 内田浩二

    第85回日本生化学会大会 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  14. LOX-1リガンドであるケトアミド型リジン付加体のLC-MS/MS解析

    柴田貴広、下津祐樹、町田幸子、加藤里奈、板部洋之、Xiaochun Zhu、Lawrence M. Sayre、内田浩二

    第84回日本生化学会大会 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  15. *A monoclonal antibody against 4-ketoamide-type 4-oxo-2-nonenal-lysine adduct International conference

    The 5th Joint Meeting ofThe Societies For Free Radical Research Australasia and Japan 

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    Event date: 2009.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    4-Oxo-2-nonenal (ONE) is one of the major lipid peroxidation products and has been recently established to be formed by free radical-initiated degradation of omega-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid. Upon reaction with protein, ONE covalently modifies the arginine, cysteine, histidine, and lysine residues. Zhu and Sayre (2007) have shown that, upon reaction with lysine residue, ONE forms a unique 4-ketoamide-type adduct, N&#61541;-(4-oxononanoyl)lysine (ONL), that arises

  16. *イソチオシアネートによるレドックス制御を介した神経細胞分化促進機構の解析

    第61回日本酸化ストレス学会学術集会 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  17. 新規脂質過酸化物4-オキソ-2-ノネナールの化学と生物

    柴田貴広、内田浩二

    第29回日本フリーラジカル学会/日本過酸化脂質・フリーラジカル学会第31回大会 合同学会 

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    Event date: 2007.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 10

  1. 相互作用タンパク質を介したピロロキノリンキノンの機能性の解明

    2023 - 2024

    2023年度 一般公募研究 

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    Authorship:Principal investigator 

    Grant amount:\1500000 ( Direct Cost: \1500000 )

  2. ビタミンB1由来酸化⽣成物の解析とその⽣理作⽤の解明

    2019.12 - 2021.3

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    Authorship:Principal investigator 

    Grant amount:\5000000 ( Direct Cost: \5000000 )

  3. 抗炎症作用を有する食品成分の探索とその作用機序の解明

    2017 - 2018

  4. 遊離脂肪酸受容体を活性化する香辛料成分の探索

    2017 - 2018

  5. 穀物タンパク質の酸化的変性と細胞応答機構の解析

    2017 - 2018

  6. タンパク質分子上に形成されるアダクトーム解析法の確立

    2013.10 - 2017.3

    さきがけ 

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    Grant type:Competitive

  7. (財)旗影会 平成24年度研究助成金

    2012.6 - 2013.3

  8. (財)加藤記念バイオサイエンス研究振興財団  奨励研究助成

    2009.4 - 2011.3

  9. (財)飯島記念食品科学振興財団 学術研究助成

    2009.4 - 2011.3

  10. ネスレ栄養科学会議研究助成 平成19年度

    2007.6

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KAKENHI (Grants-in-Aid for Scientific Research) 14

  1. 疾患状態を反映する代謝物アダクトームの解明

    Grant number:23K17449  2023.6 - 2027.3

    科学研究費助成事業  挑戦的研究(開拓)

    柴田 貴広, 中島 史恵, 佐藤恵美, 服部 浩之

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\26000000 ( Direct Cost: \20000000 、 Indirect Cost:\6000000 )

    疾患状態に起因する内因性代謝物や食品由来成分の代謝物の一部が、生体内のタンパク質に様々な付加体(アダクト)を形成していることが知られている。生体内タンパク質における代謝物アダクトの総体「代謝物アダクトーム」を明らかにすることができれば、ヒトの生体内環境や疾患状態を理解・評価できると考えられる。本研究では、代謝物アダクトーム解析法を確立し、生体内の状態や疾患状態を反映する代謝物アダクトの同定に挑戦する。

  2. 腎症超早期状態を反映する尿中エクソソームタンパク質の質的・量的変動解析

    Grant number:22H03531  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(B)

    柴田 貴広, 菊地 良介

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\17680000 ( Direct Cost: \13600000 、 Indirect Cost:\4080000 )

    本研究では、尿中エクソソームに含まれるタンパク質の量的・質的変動を基軸とした、糖尿病性腎症の超早期診断マーカーの創出を目的とする。糖尿病モデルラットの発症前段階における尿中エクソソームタンパク質の量的・質的変動を明らかにすることで、新規の分子マーカーを同定する。さらに、ヒト臨床検体を用いることで、超早期マーカーとしての有用性についても評価する。

  3. ピロロキノリンキノン受容体の同定と機能解析:ビタミン様物質の新規生理作用の解明

    Grant number:21K19073  2021.7 - 2023.3

    科学研究費助成事業  挑戦的研究(萌芽)

    柴田 貴広, 赤川 貢

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\6370000 ( Direct Cost: \4900000 、 Indirect Cost:\1470000 )

    第3の酸化還元補酵素として同定されたピロロキノリンキノン(PQQ)は、哺乳動物を含む高等動物におけるビタミン様物質として知られているものの、その多彩な生理作用を補酵素としての機能だけでは説明することができない。本研究では、ある種のGPCRがビタミン様物質PQQの受容体候補分子であると捉え、これを実証することによりPQQの新規な生理活性とその作用機序の解明に挑戦する。
    Gタンパク質共役型受容体(GPCR)の中でも、腸管上皮などに発現する代謝物感受性GPCRに注目し、ピロロキノリンキノン(PQQ)による活性化を評価した。6種類の代謝物感受性GPCRに関して、PQQによる活性化をtransforming growth factor-α(TGF-α)切断アッセイにより評価したところ、GPR35のみがPQQにより顕著に活性化されることがわかった。さらに、 PQQはその投与濃度依存的にGPR35を活性化すること、PQQの部分構造体では全く活性を示さないこと、ヒトGPR35だけでなくマウスGPR35も活性化することがわかった。
    ヒト結腸癌由来細胞株であるCaco-2細胞をモデルとしてPQQの機能について検討した。分化させたCaco2細胞にPQQを処理したところ、GPR35の下流に位置すると考えられるERKのリン酸化が認められた。このリン酸化は、GPR35のアゴニストであるCID 2745687の前処理により部分的に抑制された。このことからPQQによるERKのリン酸化にはGPR35が少なくとも部分的には関与していることが示唆された。
    GPR35とPQQが直接相互作用をするかを証明するため、また新規なPQQ受容体探索を探索するため、PQQの化学プローブを作製した。PQQと受容体タンパク質との非共有結合による相互作用を捉えるため、光反応性官能基であるベンゾフェノンおよびクリック反応のためのアルキニル基を導入したPQQプローブを作製した。さらにこのプローブを用いて、培養細胞におけるラベル実験を行ったところ、複数のタンパク質がラベル化されることがわかった。
    当初の計画通り、PQQ受容体の候補タンパク質を見出すことができた。またPQQプローブの作製も完了した。
    PQQによるGPR35活性化の意義についてさらに詳細に解析を行う。あわせて、PQQプローブを用いた標的タンパク質の探索を進めていく予定である。

  4. Diversity of oxidized lipids and their functional understanding

    Grant number:23H05481  2023.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (S)

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    Authorship:Coinvestigator(s) 

  5. Comprehensive understanding of oxidized lipids involved in disease induction

    Grant number:20H00493  2020.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\700000 ( Direct Cost: \700000 )

  6. 疫病菌交配ホルモンが制御する性分化の分子機構の全容解明とその応用

    Grant number:2818H03943  2018.4 - 2023.3

    科学研究費補助金  基盤(A)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\300000 ( Direct Cost: \300000 )

  7. Elucidation and application of molecular mechanism of Phytophthora sexual reproduction controlled by mating hormones

    Grant number:18H03943  2018.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  8. Analysis on molecular nutritional functions of bile acids as a feeding signal, and regulation of metabolic response to feeding by food factors

    Grant number:15H05781  2015.5 - 2020.3

    Sato Ryuichiro

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    Authorship:Coinvestigator(s) 

    Bile acids are secreted into the upper small intestine upon ingestion, and then taken up in the lower small intestine and returned to the liver. Since a portion of bile acids flow into the systemic bloodstream, the bile acid concentration in the blood increases after eating, which is considered to be a feeding signal. The target molecule that recognizes this is the bile acid receptor TGR5. For functional analysis in skeletal muscle, transgenic mice expressing human TGR5 in skeletal muscle were established and analyzed. It was found that activation of TGR5 by bile acid resulted in a muscle hypertrophy effect. When an oral glucose tolerance test was performed, a rapid decrease in blood glucose was confirmed, and it was clarified that an increase in muscle mass leads to an improvement in glucose intolerance. Part of the increase in muscle mass associated with the feeding response may be due to TGR5 function.

  9. 摂食シグナル胆汁酸の分子栄養学的機能解析と食品成分による摂食応答制御

    2015 - 2020.3

    科学研究費補助金  基盤研究(S)

    佐藤隆一郎

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    Authorship:Coinvestigator(s) 

  10. Formation and regulation of ligand signals associated with accepting and activating molecular oxygen

    Grant number:26111011  2014.7 - 2019.3

    Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    UCHIDA Koji

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    Authorship:Coinvestigator(s) 

    (1) We identified a novel lysine adduct as an oxidative stress-related biomarker candidate. We also unambiguously detected 2-oxo-histidine-containing dipeptides in mouse tissue homogenates. In addition, an enhanced S-thiolation of HSA in the hyperlipidemia patients was observed.(2) We identified complement component C1q as a novel AGE-binding protein. We also discovered that the EGCG could be an endogenous source of the electrically-transformed proteins that could be recognized by the natural antibodies. In addition, lactate dehydrogenase was identified as a novel a mammalian PQQ-binding protein.(3) We found that the filamin A acted as a guanine nucleotide exchange factor for Drp1 and mediated mitochondrial fission-associated myocardial senescence in mice after myocardial infarction. We also demonstrate that TRPC3 acts as a positive regulator of ROS that stabilizes Nox2 activity through physical interaction, leading to amplification of maladaptive signaling in cardiomyocytes.

  11. 脂質由来リガンドによる細胞応答と食品成分による制御

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  12. 活性酸素リガンド・レセプター反応制御のケミカルバイオロジー

    2008.4 - 2013.3

    科学研究費補助金  新学術領域研究

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    Authorship:Coinvestigator(s) 

  13. 食品由来の神経分化促進因子の探索

    2007.4 - 2009.3

    科学研究費補助金  若手研究(B)

    柴田 貴広

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    Authorship:Principal investigator 

  14. プロスタグランジンなどの脂質メディエーターに関する研究

    2003.4 - 2006.3

    科学研究費補助金 

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 4

  1. 卒業論文研究

    2022

  2. 専門セミナー

    2022

  3. 農学セミナー2

    2022

  4. 化学実験

    2022

Teaching Experience (Off-campus) 2

  1. 食品分析学

    2023.10 - 2024.3 Chubu University)

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    Level:Undergraduate (specialized) 

  2. 食品栄養科学特別講義

    2022.9 Chubu University)

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    Level:Postgraduate  Country:Japan

 

Social Contribution 3

  1. JST サイエンス・パートナーシップ・プログラム

    2014.8

  2. JST サイエンス・パートナーシップ・プログラム

    2013.8

  3. 平成24年度高文連自然科学専門部講習会

    2012.10

Media Coverage 2

  1. GABAの共同研究を学会発表 筋力向上効果 Newspaper, magazine

    食品新聞  2022.3

  2. 筋芽細胞の筋形成機能 GABAで促進 Promotional material

    化学工業日報  2022.3

Academic Activities 1

  1. Free Radical Research Editorial Board Member International contribution

    Role(s):Peer review

    2021.4

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    Type:Peer review