名古屋大学大学院医学系研究科准教授

2009.10

名古屋大学大学院医学系研究科講師

2008.4 - 2009.9

名古屋大学大学院生命農学研究科応用生命化学講座（分子生体制御学） 助教

2007.4 - 2008.3

名古屋大学大学院生命農学研究科応用生命化学講座（分子生体制御学）助手

2005.12 - 2007.3

名古屋大学医学部非常勤講師

2005.6 - 2005.12

Inhibitory machinery for the functional dystroglycan glycosylation Invited Reviewed

Kondo, Y; Okajima, T

JOURNAL OF BIOCHEMISTRY   Vol. 173 ( 5 ) page： 333 - 335   2023.5

Evidence that only EWS among the FET proteins acquires a low partitioning property for the hyperosmotic stress response by O-GlcNAc glycosylation on its low-complexity domain Reviewed

Kakuo, M; Horii, T; Tonomura, N; Sato, R; Ogawa, M; Okajima, T; Kamemura, K

EXPERIMENTAL CELL RESEARCH   Vol. 424 ( 1 ) page： 113504   2023.3

Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation Reviewed

Zhang, AL; Tsukamoto, Y; Takeuchi, H; Nishiwaki, K; Tashima, Y; Okajima, T

ANALYTICAL BIOCHEMISTRY   Vol. 656   page： 114881   2022.11

Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH1 Reviewed

Tsukamoto, Y; Ogawa, M; Yogi, K; Tashima, Y; Takeuchi, H; Okajima, T

GLYCOBIOLOGY   Vol. 32 ( 7 ) page： 616 - 628   2022.6

Significant Roles of Notch <i>O</i>-Glycosylation in Cancer Invited Reviewed

Wang, WW; Okajima, T; Takeuchi, H

MOLECULES   Vol. 27 ( 6 )   2022.3

Unique effects of expression of asialo-series ganglioside GD1alpha in human cancer cell lines Reviewed

Robiul, B; Yesmin, F; Kondo, Y; Ohkawa, Y; Ohmi, Y; Zhang, P; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE   Vol. 113   page： 379 - 379   2022.2

Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin. Reviewed

Farhana, Y; Bhuiyan, RH; Ohmi, Y; Horiuchi, M; Okajima, T; Yamamoto, S; Furukawa, K; Furukawa, K

CANCER SCIENCE   Vol. 113   page： 1104 - 1104   2022.2

Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins

Yesmin, F; Bhuiyan, RH; Ohmi, Y; Yamamoto, S; Kaneko, K; Ohkawa, Y; Zhang, P; Hamamura, K; Cheung, NKV; Kotani, N; Honke, K; Okajima, T; Kambe, M; Tajima, O; Furukawa, K; Furukawa, K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 23 ( 1 )   2022.1

Eogt-catalyzed O-GlcNAcylation Invited Reviewed

Lo, PW; Okajima, T

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY   Vol. 34 ( 197 ) page： E1 - E6   2022.1

Other Classes of Eukaryotic Glycans Invited Reviewed International coauthorship

Haltiwanger RS, Wells L, Freeze HH, Jafar-Nejad H, Okajima T, Stanley P, Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Mohnen D, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH

    2022

St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity Reviewed

Thane, P; Ohkawa, Y; Yamamoto, S; Momota, H; Kato, A; Kaneko, K; Natsume, A; Farhana, Y; Ohmi, Y; Okajima, T; Bhuiyan, RH; Wakabayashi, T; Furukawa, K; Furukawa, K

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 3 ) page： 535 - 549   2021.8

Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in <i>O</i>-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes Reviewed

Ohmi, Y; Nishikaze, T; Kitaura, Y; Ito, T; Yamamoto, S; Sugiyama, F; Matsuyama, M; Takahashi, Y; Takeda, A; Kawahara, T; Okajima, T; Furukawa, K; Furukawa, K

GLYCOBIOLOGY   Vol. 31 ( 5 ) page： 557 - 570   2021.5

Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and <i>L</i>-fringe in Pancreatic Cancers Reviewed

Barua, R; Mizuno, K; Tashima, Y; Ogawa, M; Takeuchi, H; Taguchi, A; Okajima, T

MOLECULES   Vol. 26 ( 4 )   2021.2

Current Views on the Roles of <i>O</i>-Glycosylation in Controlling Notch-Ligand Interactions Invited Reviewed

Saiki, W; Ma, CY; Okajima, T; Takeuchi, H

BIOMOLECULES   Vol. 11 ( 2 )   2021.2

Roles of asialo-series ganglioside GD1α in human cancer cell lines. Reviewed

Bhuiyan, RH; Yesmin, F; Kondo, Y; Ohkawa, Y; Ohmi, Y; Zhang, P; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE   Vol. 112   page： 679 - 679   2021.2

Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin. Reviewed

Yesmin, F; Bhuiyan, RH; Ohmi, Y; Okajima, T; Yamamoto, S; Furukawa, K; Furukawa, K

CANCER SCIENCE   Vol. 112   page： 699 - 699   2021.2

Enzyme assay of O-fucosyltransferase 1 using Drosophila OFUT1.

Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, Okajima T

    2021

Enzyme assay of O-GlcNAc transferase.

Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, Alam SMD, Okajima T

    2021

3′-Sialyllactose on Notch: NOTCH1 functions as a scafold of O-linked, 3′-sialyllactosylated glycans

Tsukamoto, Y; Aoki, K; Narimatsu, Y; Urata, Y; Saiki, W; Ogawa, M; Clausen, H; Tiemeyer, M; Okajima, T; Takeuchi, H

GLYCOBIOLOGY   Vol. 30 ( 12 ) page： 1119 - 1120   2020.12

N-glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization

Alam, SMD; Tsukamoto, Y; Ogawa, M; Senoo, Y; Ikeda, K; Tashima, Y; Takeuchi, H; Okajima, T

GLYCOBIOLOGY   Vol. 30 ( 12 ) page： 1031 - 1032   2020.12

Comprehensive O-GlcNAc glycoproteomics on NOTCH1 EGF repeats refined the sequons for O-GlcNAcylation and uncovered unique Lewis X epitopes in mammals

Ogawa, M; Tsukamoto, Y; Yogi, K; Senoo, Y; Ikeda, K; Takeuchi, H; Okajima, T

GLYCOBIOLOGY   Vol. 30 ( 12 ) page： 1086 - 1087   2020.12

Glycoproteomic analysis identifies cryptdin-related sequence 1 as <i>O</i>-glycosylated protein modified with α1,2-fucose in the small intestine Reviewed

Hashiguchi, H; Tsukamoto, Y; Ogawa, M; Tashima, Y; Takeuchi, H; Nakamura, M; Kawashima, H; Fujishiro, M; Okajima, T

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 695   page： 108653   2020.11

Differential Labeling of Glycoproteins with Alkynyl Fucose Analogs Reviewed

Ma Chenyu, Takeuchi Hideyuki, Hao Huilin, Yonekawa Chizuko, Nakajima Kazuki, Nagae Masamichi, Okajima Tetsuya, Haltiwanger Robert S., Kizuka Yasuhiko

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 21 ( 17 )   2020.9

Aminoglycosides are efficient reagents to induce readthrough of premature termination codon in mutant B4GALNT1 genes found in families of hereditary spastic paraplegia.

Yesmin F, Bhuiyan RH, Ohmi Y, Ohkawa Y, Tajima O, Okajima T, Furukawa K, Furukawa K

Journal of biochemistry   Vol. 168 ( 2 ) page： 103 - 112   2020.8

N-Glycans on EGF domain-specificO-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization

Alam Sayad Md. Didarul, Tsukamoto Yohei, Ogawa Mitsutaka, Senoo Yuya, Ikeda Kazutaka, Tashima Yuko, Takeuchi Hideyuki, Okajima Tetsuya

JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 295 ( 25 ) page： 8560 - 8574   2020.6

Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking

Ogawa Mitsutaka, Tashima Yuko, Sakaguchi Yamato, Takeuchi Hideyuki, Okajima Tetsuya

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 526 ( 1 ) page： 184 - 190   2020.5

Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking

Urata Yusuke, Saiki Wataru, Tsukamoto Yohei, Sago Hiroaki, Hibi Hideharu, Okajima Tetsuya, Takeuchi Hideyuki

CELLS   Vol. 9 ( 5 )   2020.5

The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface

Hashimoto Noboru, Ito Shizuka, Tsuchida Akiko, Bhuiyan Robiul H., Okajima Tetsuya, Yamamoto Akihito, Furukawa Keiko, Ohmi Yuhsuke, Furukawa Koichi

JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 294 ( 28 ) page： 10833 - 10845   2019.7

Extracellular O-GlcNAc: From Discovery to Current Developments

Okajima Tetsuya

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY   Vol. 31 ( 181 ) page： SE57 - SE58   2019.7

Structure and function of extracellular <i>O</i>-GlcNAc Invited Reviewed

Ogawa, M; Okajima, T

CURRENT OPINION IN STRUCTURAL BIOLOGY   Vol. 56   page： 72 - 77   2019.6

Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice

Bhuiyan Robiul H., Ohmi Yuhsuke, Ohkawa Yuki, Zhang Pu, Takano Maiko, Hashimoto Noboru, Okajima Tetsuya, Furukawa Keiko, Furukawa Koichi

NEUROSCIENCE   Vol. 397   page： 94 - 106   2019.1

Structure and function of extracellular O-GlcNAc Invited Reviewed

Mitsutaka Ogawa, Tetsuya Okajima

Current Opinion in Structural Biology   Vol. 56   page： 72-77   2019

Significant roles of O-glucose glycans in mammalian Notch trafficking and signaling

Takeuchi, H; Yu, HJ; Hao, HL; Urata, Y; Senoo, Y; Tsukamoto, Y; Saiki, W; Takeuchi, M; Ito, A; Li, HL; Okajima, T; Haltiwanger, RS

GLYCOBIOLOGY   Vol. 28 ( 12 ) page： 1017 - 1018   2018.12

Exploring the significance of xylosyl-extension of O-glucose glycans on EGF repeats for Notch signaling in mammals

Saiki, W; Urata, Y; Senoo, Y; Tsukamoto, Y; Ma, CY; Okajima, T; Takeuchi, H

GLYCOBIOLOGY   Vol. 28 ( 12 ) page： 1028 - 1029   2018.12

Roles of asialo-series ganglioside GD1alpha in human cancer cell lines

Bhuiyan, RH; Kondo, Y; Ohkawa, Y; Ohmi, Y; Zhang, P; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE   Vol. 109   page： 877 - 877   2018.12

Roles of ganglioside GD3 in the regulation of microenvironment of gliomas

Zhang, P; Ohkawa, Y; Ohmi, Y; Robiul, HB; Kato, A; Furukawa, K; Okajima, T; Wakabayashi, T; Furukawa, K

CANCER SCIENCE   Vol. 109   page： 262 - 262   2018.12

Whole mount staining of retina

Mitsutaka Ogawa, Tetsuya Okajima

bio-101   Vol. 8 ( 19 ) page： e3034   2018.10

Isolation of Murine Brain and Lung Microvascular Endothelial Cells Invited Reviewed

Ailing Zhang, Shogo Sawaguchi, Entzu Wan, Mitsutaka Ogawa, Tetsuya Okajima

bio-101     2018.8

Congenital diseases caused by defective O-glycosylation of Notch receptors

Tashima Yuko, Okajima Tetsuya

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 3 ) page： 299 - 307   2018.8

Structural Divergence in <i>O</i>-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1.

Ogawa M, Senoo Y, Ikeda K, Takeuchi H, Okajima T

Molecules (Basel, Switzerland)   Vol. 23 ( 7 )   2018.7

NOTCH SIGNALING A sweet strategy

Okajima Tetsuya

NATURE CHEMICAL BIOLOGY   Vol. 14 ( 1 ) page： 3 - 4   2018.1

Ganglioside GD3/GD2 enhance malignant properties of human glioma U251 cells

Zhang, P; Iwasawa, T; Ohkawa, Y; Bhuiyan, RH; Momota, H; Wakabayashi, T; Ohmi, Y; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE   Vol. 109   page： 256 - 256   2018.1

Protocol for Notch-ligand Binding Assays Using Dynabeads Invited Reviewed

bio-protocol     2017.10

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

Sawaguchi Shogo, Varshney Shweta, Ogawa Mitsutaka, Sakaidani Yuta, Yagi Hirokazu, Takeshita Kyosuke, Murohara Toyoaki, Kato Koichi, Sundaram Subha, Stanley Pamela, Okajima Tetsuya

ELIFE   Vol. 6   2017.4

Neogenin defined as a GD3-associated molecule by enzyme-mediated activation of radical sources confers malignant properties via intra-cytoplasmic domain in melanoma cells.  Reviewed

Kaneko K, Ohkawa Y, Hashimoto N, Ohmi Y, Kotani N, Honke K, Ogawa M, Okajima T, Furukawa K, Furukawa K

J. Biol. Chem.   Vol. 291   page： 16630-16643   2016

Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated EGF domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome.

Ogawa M, Sawaguchi S, Kawai T, Nadano D, Matsuda T, Yagi H, Kato K, Furukawa K, Okajima T.

J Biol Chem     page： in press   2015

O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation. Reviewed

Ishio A, Sasamura T, Ayukawa T, Kuroda J, Ishikawa HO, Aoyama N, Matsumoto K, Gushiken T, Okajima T, Yamakawa T, Matsuno K.

J Biol Chem     page： in press   2015

Extracellular O-linked beta-N-acetylglucosamine: Its biology and relationship to human disease. Invited Reviewed

Ogawa M, Furukawa K, Okajima T.

World J Biol Chem   Vol. 5   page： 224-230   2014

Allergenic potential of rice-pollen proteins: expression, immuno-cross reactivity and IgE-binding.

  Vol. 154   page： 195-205   2013

Dephosphorylation reduces passage of ovalbumin antigen through intestinal epithelial Caco-2 cell monolayers.

  Vol. 153   page： 347-354   2013

GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl-glucosamine epitopes reactive with CTD110.6 antibody. Reviewed

  Vol. 440   page： 88-93   2013

Post-weaning increases in the milk-fat globule EGF-factor VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells. Reviewed

  Vol. 153   page： 31-41   2013

Trimeric Tn Antigen on Syndecan 1 Produced by ppGalNAc-T13 Enhances Cancer Metastasis via a Complex Formation with Integrin alpha5beta1 and Matrix Metalloproteinase 9. Reviewed

  Vol. 288   page： 24264-24276   2013

O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1.

  Vol. 419   page： 14-19   2012

pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen. Reviewed

  Vol. 419   page： 7-13   2012

Discharge of solubilized and Dectin-1-reactive beta-glucan from macrophage cells phagocytizing insoluble beta-glucan particles: Involvement of reactive oxygen species (ROS)-driven degradation. Reviewed

  Vol. 421   page： 329-334   2012

O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions Reviewed

  Vol. 2   page： 583   2011.12

Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin

  Vol. 508   page： 87-92   2011

Specific O-glycosylation modifying epidermal growth factor domains.

  Vol. 83   page： 813-821   2011

Strong antibody reaction against glycosphingolipids injected in liposome-embedded forms in beta3GN-T5 knockout mice.

  Vol. 73   page： 137-146   2011

Establishment of a Mammary Stromal Fibroblastic Cell Line for In Vitro Studies in Mice of Mammary Adipocyte Differentiation. Reviewed

Nakatani H, Aoki N, Okajima T, Nadano D, Flint D, Matsuda T.

Biol. Reprod.   Vol. 82   page： 44-53   2010

O-GlcNAc modification on EGF domains of Notch receptors.

Sakaidani Y, Furukawa K, Okajima T.

Methods Enzymol.   Vol. 480   page： 355-73   2010

Proteomic Analysis of Rodent Ribosomes Revealed Heterogeneity Including Ribosomal Proteins L10-like, L22-like 1, and L39-like. Reviewed

Sugihara Y, Honda H, Iida T, Morinaga T, Hino S, Okajima T, Matsuda T, Nadano D.

J. Proteome Res.   Vol. 9   page： 1351-66   2010

Roles of glycosylation in Notch signaling.

  Vol. 92   page： 131-164   2010

Binding of Norovirus virus-like particles (VLPs) to human intestinal Caco-2 cells and the sup-pressive effect of pasteurized bovine colostrum on this VLP binding.

  Vol. 74   page： 541-547.   2010

Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland.

  Vol. 28   page： 321-328   2010

IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing ß-(1,2)-xylose and α-(1,3)-fucose

  Vol. 133   page： 28-34   2010

Periodate-resistant carbohydrate epitopes recognized by IgG and IgE antibodies from some of the immunized mice and patients with allergy. Reviewed

Hino S, Matsubara T, Urisu A, Aoki N, Sato C, Okajima T, Nadano D, Matsuda T.

Biochem. Biophys Res. Commun.   Vol. 380   page： 632-637   2009

Glycoconjugate glycosyltransferases. Invited Reviewed

Furukawa K, Tsuchida A, Okajima T, Furukawa K.

Glycoconj. J.   Vol. 26   page： 987-998   2009

Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling Reviewed

Okajima T, Reddy B, Matsuda T and Irvine KD

BMC biology   Vol. 6 ( 1 ) page： 1-26   2008.1

Suppressive expression of the glutelin A1-collagen peptide fusion gene in hybrid rice lines with the mutant line, Low Glutelin Content-1 (LGC-1) Reviewed

Hashizume F, Hino S, Okajima T, Nadano D, Aoki N and Matsuda T

Plant Biotechnol   Vol. 25   page： 465-471   2008

Development and evaluation of transgenic rice seeds accumulating a type II-collagen tolerogenic peptide Reviewed

Hashizume F, Hino S, Kakehashi M, Okajima T , Nadano D, Aoki N, and Matsuda T

Transgenic Research   Vol. 17   page： 1117-1129   2008

Glycoconjugate glycosyltransferases Invited Reviewed

Furukawa K, Tsuchida A, Okajima T, Furukawa K

Glycoconj. J   Vol. 26   page： 987-98   2008

Engineering of a mammalian O-glycosylation pathway in the yeast Saccharomyces cerevisiae: production of O-fucosylated epidermal growth factor domains Reviewed

Yuko Chigira, Takuji Oka, Tetsuya Okajima and Yoshifumi Jigami

Glycobiology   Vol. 18   page： 303-314   2008

Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis Invited Reviewed

Okajima T, Matsuura A, Matsuda T

J. Biochem.   Vol. 144   page： 1-6   2008

Absorption, Migration and Kinetics in Peripheral Blood of Orally Administered Ovalbumin in a Mouse Model Reviewed

Matsubara T, Aoki N, Honjoh T, Mizumachi K, Kurisaki JI, Okajima T, Nadano D, Matsuda T

Biosci. Biotechnol. Biochem.   Vol. 72   page： 2555-2565   2008

*O-linked GlcNAc is present on the extracellular domain of Notch receptors. Reviewed

Matsuura A, Ito M, Sakaidani Y, Kondo T, Murakami K, Furukawa K, Nadano D, Matsuda T, and Okajima T

J. Biol. Chem.   Vol. 283 ( 51 ) page： 35486-35495   2008

Glycosyltransferases involved in O-fucose glycan synthesis.

Okajima T, Matsuda T

Experimental Glycoscience     page： 33-35   2008

糖転移酵素のNotch受容体フォールディングにおける役割

松浦愛子・松田幹・岡島徹也

蛋白質核酸酵素   Vol. 53   page： 1480-1485   2008

Serum and monoclonal IgE antibodies from NC/Nga mice with severe atopic-like dermatitis recognize an autoantigen, histone H3. Reviewed

Matsubara T, Aoki N, Hino H, Okajima T, Nadano D, Matsuda T

Clin. Exp. Allergy   Vol. 39   page： 579-590   2008

Association of chicken zona pellucida glycoprotein (ZP) B1 with ZPC induces formation of ZPB1-ZPC fibrous aggregates containing disulfide-bridged ZPB1 dimer. Reviewed

Okumura H, Okajima T, Nadano D, Matsuda T.

Biochem Biophys Res Commun.   Vol. 364 ( 3 ) page： 682-688   2007.12

Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis. Reviewed

Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D.

Biochem J   Vol. 404 ( 3 ) page： 373-381   2007.6

Roles of fucosyltransferase and fucose in Notch signaling Invited

Okajima T, Matuda T.

Methods Enzymol   Vol. 417   page： 116-26   2006

*Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding. Reviewed

Okajima T, Xu A, Lei L, Irvine KD.

Science   Vol. 307   page： 1599-603   2005.3

*Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. Invited Reviewed

Okajima T, Xu A, Irvine KD.

J Biol Chem.   Vol. 278   page： 42340-5   2003.10

Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. Reviewed

Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K.

J Biol Chem.   Vol. 278   page： 22787-94   2003.6

XGalT-1 involved in the synthesis of glyosaminoglycans of proteoglycans and Ehlers-Danlos syndrome (progeroid type) Invited

Furukawa K, Okajima T, Nakamura Y.

Tanpakushitsu Kakusan Koso.   Vol. 48 ( 8 Suppl ) page： 1152-7   2003.1

*Regulation of notch signaling by O-linked fucose. Invited Reviewed

Okajima T, Irvine KD.

Cell   Vol. 111   page： 893-904   2002.12

Galactosyltransferase I is a gene responsible for progeroid variant of Ehlers-Danlos syndrome: molecular cloning and identification of mutations. Invited

Furukawa K, Okajima T.

Biochim Biophys Acta.   Vol. 1573 ( 3 ) page： 377-81   2002.12

Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis. Reviewed

Nakamura Y, Haines N, Chen J, Okajima T, Furukawa K, Urano T, Stanley P, Irvine KD, Furukawa K.

J Biol Chem.   Vol. 277 ( 48 ) page： 46280-8   2002.11

b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. Reviewed

Okada M, Itoh Mi M, Haraguchi M, Okajima T, Inoue M, Oishi H, Matsuda Y, Iwamoto T, Kawano T, Fukumoto S, Miyazaki H, Furukawa K, Aizawa S, Furukawa K.

J Biol Chem.   Vol. 277 ( 3 ) page： 1633-6   2002.1

Expression cloning of human globoside synthase cDNAs: Identification of β3Gal-T3 as UDP-N-acetylgalactosamine: globotriaosylceramide β1,3-N-acetyl-galactosaminyltransferase. Reviewed

Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata Si, Furukawa K, Urano T, Furukawa K

J. Biol. Chem.   Vol. 275   page： 40498-40503   2000

Molecular cloning and expression of mouse GD1α/GT1aα/GQ1bα synthase (ST6GalNAc VI) gene. Reviewed

Okajima T, Chen HH, Ito H, Kiso M, Tai T, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem.   Vol. 275   page： 6717-6723   2000

Molecular cloning of Gb3/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo-series glycosphingolipids. Reviewed

Kojima Y, Fukumoto S, Furukawa K, Okajima T, Wiels J, Yokoyama K, Suzuki Y, Urano T, Ohta M, Furukawa K.

J. Biol. Chem.   Vol. 275   page： 15152-15156   2000

Assignment of human xylosylprotein beta-1,4-galactosyltransferase gene (B4GALT7) to human chromosome 5q35.2-->q35.3 by in situ hybridization. Reviewed

Kuroiwa A, Matsuda Y, Okajima T, Furukawa K

Cytogenet. Cell Genet.   Vol. 89   page： 8-9   2000

Molecular basis for the p phenotype: Identification of distinct and multiple mutations in the α1,4-galactosyltransferase gene in Swedish and Japanese individuals. Reviewed

Furukawa K, Iwamura K, Uchikawa M, Sojka BN, Wiels J, Okajima T, Urano T, Furukawa K.

J. Biol. Chem.   Vol. 275   page： 37752-37756   2000

Molecular cloning of brain-specific GD1α synthase (ST6GalNAc V) containing CAG/Glutamine repeats. Reviewed

Okajima T, Fukumoto S, Ito H, Kiso M, Hirabayashi Y, Urano T, Furukawa K, Furukawa K.

J. Biol. Chem   Vol. 274   page： 30557-30562   1999

Molecular cloning of a novel α2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. Reviewed

Okajima T, Fukumoto S, Miyazaki H, Ishida H, Kiso M, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem.   Vol. 274   page： 11479-11486   1999

Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. Reviewed

Okajima T, Yoshida K, Kondo T, Furukawa K.

J. Biol. Chem.   Vol. 274   page： 22915-22918   1999

*Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene. Reviewed

Okajima T, Fukumoto S, Furukawa K, Urano T, Furukawa K.

J. Biol. Chem.   Vol. 274   page： 28841-28844   1999

Nuclear localization of Ca2+/calmodulin-dependent protein kinase IV and calspermin. Reviewed

Okajima T, Okuno S, Fujisawa H, Hagiwara M.

Bioimages   Vol. 4   page： 117-128   1996

RNA priming coupled with DNA synthesis on natural template by calf thymus DNA polymerase α-primase. Reviewed

Suzuki M, Savoysky E, Izuta S, Tatebe M, Okajima T, Yoshida S.

Biochemistry   Vol. 32   page： 12782-92   1993

Experimental Glycoscience, Editors: Taniguchi, N. et al. Glycosyltransferases involved in O-fucose glycan synthesis.

Okajima T, Matsuda T.（ Role： Joint author）

Elsevier  2008 

EGFドメインに見いだされる新型糖鎖と生体機能制御

岡島徹也（ Role： Sole author）

化学と生物  2006.12 

未来を拓く糖鎖科学

岡島徹也　古川鋼一（ Role： Joint author）

金芳社  2005.12 

O-フコース型糖鎖によるNotchシグナル制御の分子機構

岡島徹也（ Role： Sole author）

実験医学  2004 

O-フコース型糖鎖によるNotchシグナルの制御

岡島徹也（ Role： Sole author）

医学のあゆみ  2003 

プロテオグリカンの糖鎖の合成にかかわるXgalT-1とEhlers-Danlos症候群（早老型）

古川鋼一・岡島徹也・中村陽子（ Role： Joint author）

蛋白質核酸酵素  2003 

ガングリオシドGD3と増殖・アポトーシスシグナル

古川鋼一，福本　敏，井上雅博，岡田雅彦，大石秀人，岡島徹也，古川圭子（ Role： Joint author）

細胞工学  2001 

Roles of N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT)-catalyzed Notch1 O-GlcNAcylation and Notch signaling International conference

Sayad Md. Didarul Alam, Mitsutaka Ogawa, Hideyuki Takeuchi and Tetsuya Okajima

Roles of ganglioside GD3 in the regulation of microenvironment of gliomas

Zhang P,Ohkawa Y, Momota H, Wakabayashi T, Ohmi Y, Bhuiyan RH, Furukawa Keiko,Okajima Tetsuya, Furukawa Koichi.

細胞外O-GlcNAcの修飾に関わるEOGT変異マウスの表現型解析 International conference

澤口 翔伍、小川 光貴、矢木 宏和、加藤 晃一、岡島 徹也

2017年度生命科学系学会合同年次大会 

 脳血管内皮細胞分化におけるNotch受容体O-GlcNAc修飾の役割 International conference

平泉 光佑、澤口 翔伍、岡島 徹也

2017年度生命科学系学会合同年次大会 

ガングリオシドGD3によるグリオーマの腫瘍微小環境の制御機構 Invited International conference

Zhang P,Ohkawa Y, Momota H, Wakabayashi T, Ohmi Y, Bhuiyan RH, Furukawa Keiko,Okajima Tetsuya, Furukawa Koichi.

2017年度生命科学系学会合同年次大会 

Mass Spectrometric analysis of O-GlcNAcylation on Notch EGF and function of N-Glycosylations on EGF domain-specific O-GlcNAc transferase (EOGT) International conference

Sayad Md. Didarul Alam, Mitsutaka Ogawa, Hideyuki Takeuchi and Tetsuya Okajima

Requirement of O-fucosyltransferases for Developmental Processes International conference

GlycoT 2006 

Chaperone activity of Protein O-fucosyltransferase I promotes Notch receptor folding. International conference

HFSP 4th Awardees Annual Meeting 

Chaperone activity of Protein O-fucosyltransferase I within the endoplasmic reticulum promotes folding of the Notch receptor.

Gordon Conference 

Chaperone activity of Protein O-fucosyltransferase I promotes Notch receptor folding. International conference

46th Annual Drosophila Research Conference 

Action of Protein O-fucosyltransferase 1 within the endoplasmic reticulum in maturation of the Notch receptor

US/Japan Glyco 

Chaperone activity of Protein O-fucosyltransferase I within the endoplasmic reticulum promotes folding of the Notch receptor. International conference

GlycoT 2004 

Modulation of Notch-lingad binding by protein O-fucosyltransferase and fringe International conference

HFSP 4th Awardees Annual Meeting 

Modulation of Notch-lingad binding by protein O-fucosyltransferase and fringe International conference

45th Annual Drosophila Research Conference 

EGFドメイン特異的糖転移酵素のよるNotch受容体の 構造•機能の調節機構

2006.4 - 2007.3

中島記念国際交流財団　日本人若手研究者研究助成金 

上皮成長因子様ドメインに特徴的な新規翻訳後修飾の同定と修飾機構の解析

2009.4 - 2011.3

科学研究費補助金  若手研究(B)

岡島徹也

Ｏｆｕｔ１によるＮｏｔｃｈ受容体の構造・機能の調節機構

2006.4 - 2009.3

科学研究費補助金  若手研究(A)

岡島　徹也

糖転移酵素群によるNOTCHタンパク質の分泌・分解の仕分け機構の解明

Grant number：22H02815  2022.4 - 2025.3

科学研究費助成事業  基盤研究(B)

岡島 徹也, 近藤 裕史, 竹内 英之

糖転移酵素群によるNOTCHタンパク質の分泌・分解の仕分け機構の解明

Grant number：23K24077  2022.4 - 2025.3

科学研究費助成事業  基盤研究(B)

岡島 徹也, 近藤 裕史, 竹内 英之

加齢に伴う運動能力低下におけるNotch1上の細胞外O-GlcNAc機能の解明

Grant number：20F20410  2020.11 - 2023.3

科学研究費助成事業  特別研究員奨励費

岡島 徹也, LO PEIWEN

Integrated analysis of atypical glycosylation as a basis for precise regulation of Notch signaling in the vascular endothelium

Grant number：19H03416  2019.4 - 2022.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Okajima Tetsuya

Regulation of Notch signaling in muscle satellite cells by O-glucose glycosylation

Grant number：19H03176  2019.4 - 2022.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Takeuchi Hideyuki

Roles of Notch signaling and hexosamine pathway on regulation of blood brain barrier

Grant number：15K15064  2015.4 - 2018.3

OKAJIMA Tetsuya

Roles of extracellular O-GlcNAc on Notch signaling and vascular development

Grant number：26291020  2014.4 - 2018.3

OKAJIMA Tetsuya

人体機能学

2015