研究者詳細 - 井上　直子

論文 - 井上　直子

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Morphological Analysis of the Hindbrain Glucose Sensor-Hypothalamic Neural Pathway Activated by Hindbrain Glucoprivation

Sato Marimo, Minabe Shiori, Sakono Takahiro, Magata Fumie, Nakamura Sho, Watanabe Youki, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko, Matsuda Fuko

ENDOCRINOLOGY 162 巻 ( 9 ) 2021年9月

記述言語：日本語出版者・発行元：Endocrinology (United States)

Lowered glucose availability, sensed by the hindbrain, has been suggested to enhance gluconeogenesis and food intake as well as suppress reproductive function. In fact, our previous histological and in vitro studies suggest that hindbrain ependymal cells function as a glucose sensor. The present study aimed to clarify the hindbrain glucose sensor-hypothalamic neural pathway activated in response to hindbrain glucoprivation to mediate counterregulatory physiological responses. Administration of 2-deoxy-D-glucose (2DG), an inhibitor of glucose utilization, into the fourth ventricle (4V) of male rats for 0.5 hour induced messenger RNA (mRNA) expression of c-fos, a marker for cellular activation, in ependymal cells in the 4V, but not in the lateral ventricle, the third ventricle or the central canal without a significant change in blood glucose and testosterone levels. Administration of 2DG into the 4V for 1 hour significantly increased blood glucose levels, food intake, and decreased blood testosterone levels. Simultaneously, the expression of c-Fos protein was detected in the 4V ependymal cells; dopamine β-hydroxylase-immunoreactive cells in the C1, C2, and A6 regions; neuropeptideY (NPY) mRNA-positive cells in the C2; corticotropin-releasing hormone (CRH) mRNA-positive cells in the hypothalamic paraventricular nucleus (PVN); and NPY mRNA-positive cells in the arcuate nucleus (ARC).Taken together, these results suggest that lowered glucose availability, sensed by 4V ependymal cells, activates hindbrain catecholaminergic and/or NPY neurons followed by CRH neurons in the PVN and NPY neurons in the ARC, thereby leading to counterregulatory responses, such as an enhancement of gluconeogenesis, increased food intake, and suppression of sex steroid secretion.

DOI： 10.1210/endocr/bqab125

Web of Science

Scopus

PubMed

Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction.

Uenoyama Y, Nagae M, Tsuchida H, Inoue N, Tsukamura H

Frontiers in endocrinology 12 巻頁： 724632 2021年

Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kissl knockout mice

Ikegami Kana, Goto Teppei, Nakamura Sho, Watanabe Youki, Sugimoto Arisa, Majarune Sutisa, Horihata Kei, Nagae Mayuko, Tomikawa Junko, Imamura Takuya, Sanbo Makoto, Hirabayashi Masumi, Inoue Naoko, Maeda Kei-ichiro, Tsukamura Hiroko, Uenoyama Yoshihisa

JOURNAL OF REPRODUCTION AND DEVELOPMENT 66 巻 ( 4 ) 頁： 359 - 367 2020年8月

Retinoblastoma binding protein 7 is involved in Kiss1 mRNA upregulation in rodents.

Horihata K, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H

The Journal of reproduction and development 66 巻 ( 2 ) 頁： 125 - 133 2020年4月

Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator. 査読有り

Nagae M, Uenoyama Y, Okamoto S, Tsuchida H, Ikegami K, Goto T, Majarune S, Nakamura S, Sanbo M, Hirabayashi M, Kobayashi K, Inoue N, Tsukamura H

Proceedings of the National Academy of Sciences of the United States of America 118 巻 ( 5 ) 2021年2月

Mating-induced increase in Kiss1 mRNA expression in the anteroventral periventricular nucleus prior to an increase in LH and testosterone release in male rats. 査読有り

Watanabe Y, Ikegami K, Nakamura S, Uenoyama Y, Ozawa H, Maeda KI, Tsukamura H, Inoue N

The Journal of reproduction and development 66 巻 ( 6 ) 頁： 579 - 586 2020年12月

Seasonal changes in the reproductive performance in local cows receiving artificial insemination in the Pursat province of Cambodia 招待有り国際共著

Tep Bengthay, Morita Yasuhiro, Matsuyama Shuichi, Ohkura Satoshi, Inoue Naoko, Tsukamura Hiroko, Uenoyama Yoshihisa, Pheng Vutha

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 33 巻 ( 12 ) 頁： 1922 - 1929 2020年12月

Paraventricular Dynorphin A Neurons Mediate LH Pulse Suppression Induced by Hindbrain Glucoprivation in Female Rats 査読有り

Tsuchida Hitomi, Mostari Parvin, Yamada Koki, Miyazaki Sae, Enomoto Yuki, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko

ENDOCRINOLOGY 161 巻 ( 11 ) 2020年11月

Facilitatory and inhibitory role of central amylin administration in the regulation of the gonadotropin-releasing hormone pulse generator activity in goats 査読有り

Kitagawa Yuri, Sasaki Takuya, Suzumura Reika, Morishima Ai, Tatebayashi Ryoki, Assadullah, Ieda Nahoko, Morita Yasuhiro, Matsuyama Shuichi, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko, Ohkura Satoshi

NEUROSCIENCE LETTERS 736 巻頁： 135276 2020年9月

Testosterone Supplementation Rescues Spermatogenesis and In Vitro Fertilizing Ability of Sperm in Kiss1 Knockout Mice 査読有り

Goto Teppei, Hirabayashi Masumi, Watanabe Youki, Sanbo Makoto, Tomita Koichi, Inoue Naoko, Tsukamura Hiroko, Uenoyama Yoshihisa

ENDOCRINOLOGY 161 巻 ( 9 ) 2020年9月

Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice. 査読有り

Ikegami K, Goto T, Nakamura S, Watanabe Y, Sugimoto A, Majarune S, Horihata K, Nagae M, Tomikawa J, Imamura T, Sanbo M, Hirabayashi M, Inoue N, Maeda KI, Tsukamura H, Uenoyama Y

The Journal of reproduction and development 66 巻 ( 4 ) 頁： 359 - 367 2020年8月

Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice 査読有り

Minabe Shiori, Nakamura Sho, Fukushima Eri, Sato Marimo, Ikegami Kana, Goto Teppei, Sanbo Makoto, Hirabayashi Masumi, Tomikawa Junko, Imamura Takuya, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko, Maeda Kei-Ichiro, Matsuda Fuko

JOURNAL OF REPRODUCTION AND DEVELOPMENT 66 巻 ( 4 ) 頁： 369 - 375 2020年8月

Establishment of immortalised cell lines derived from female Shiba goat KNDy and GnRH neurones 査読有り

Suetomi Yuta, Tatebayashi Ryoki, Sonoda Shuhei, Munetomo Arisa, Matsuyama Shuichi, Inoue Naoko, Uenoyama Yoshihisa, Takeuchi Yukari, Tsukamura Hiroko, Ohkura Satoshi, Matsuda Fuko

JOURNAL OF NEUROENDOCRINOLOGY 32 巻 ( 6 ) 頁： e12857 2020年6月

Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats. 査読有り

Sasaki T, Sonoda T, Tatebayashi R, Kitagawa Y, Oishi S, Yamamoto K, Fujii N, Inoue N, Uenoyama Y, Tsukamura H, Maeda KI, Matsuda F, Morita Y, Matsuyama S, Ohkura S

The Journal of reproduction and development 2020年4月

GnRH(1-5), a metabolite of gonadotropin-releasing hormone, enhances luteinizing hormone release via activation of kisspeptin neurons in female rats 査読有り

Ieda Nahoko, Assadullah, Minabe Shiori, Ikegami Kana, Watanabe Youki, Sugimoto Yusuke, Sugimoto Arisa, Kawai Narumi, Ishii Hirotaka, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko

ENDOCRINE JOURNAL 67 巻 ( 4 ) 頁： 409 - 418 2020年

Role of kisspeptin neurons as a GnRH surge generator: Comparative aspects in rodents and non-rodent mammals 査読有り

Matsuda Fuko, Ohkura Satoshi, Magata Fumie, Munetomo Arisa, Chen Jing, Sato Marimo, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 45 巻 ( 12 ) 頁： 2318 - 2329 2019年12月

Ad libitum feeding triggers puberty onset associated with increases in arcuate Kiss1 and Pdyn expression in growth-retarded rats 査読有り

Majarune Sutisa, Nima Pelden, Sugimoto Arisa, Nagae Mayuko, Inoue Naoko, Tsukamura Hiroko, Uenoyama Yoshihisa

JOURNAL OF REPRODUCTION AND DEVELOPMENT 65 巻 ( 5 ) 頁： 397 - 406 2019年10月

Central Mechanism Controlling Pubertal Onset in Mammals: A Triggering Role of Kisspeptin

Uenoyama Yoshihisa, Inoue Naoko, Nakamura Sho, Tsukamura Hiroko

FRONTIERS IN ENDOCRINOLOGY 10 巻頁： 312 2019年5月

Neonatal Estrogen Causes Irreversible Male Infertility via Specific Suppressive Action on Hypothalamic Kiss1 Neurons

Minabe Shiori, Sato Marimo, Inoue Naoko, Watanabe Youki, Magata Fumie, Matsuda Fuko, Uenoyama Yoshihisa, Ozawa Hitoshi, Tsukamura Hiroko

ENDOCRINOLOGY 160 巻 ( 5 ) 頁： 1223 - 1233 2019年5月

Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse Suppression in Lactating Rats

Sugimoto Arisa, Tsuchida Hitomi, Ieda Nahoko, Ikegami Kana, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko

ENDOCRINOLOGY 160 巻 ( 2 ) 頁： 473-483 2019年2月

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