-
Conformational change of the hairpin-like structured Robo2 ectodomain allows NELL1/2 binding.
Reviewed
1. Miyaguchi, M., Nakanishi, Y., Maturana, A.D., Mizutani, K., and Niimi, T.
Journal of Molecular Biology
Vol.
434
page：
167777
2022.10
-
Glu592 of the axon guidance receptor ROBO3 mediates a pH-dependent interaction with NELL2 ligand
Mizutani, K; Toyoda, M; Ojima-Kato, T; Maturana, AD; Niimi, T
FEBS LETTERS
Vol.
599
(
4
)
page：
571
-
580
2024.11
-
Roles of Slit Ligands and Their Roundabout (Robo) Family of Receptors in Bone Remodeling.
Invited
Reviewed
Advances in Experimental Medicine and Biology
Vol.
21
page：
143
-
154
2021
-
Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2
Yamamoto Naoka, Kashiwagi Manabu, Ishihara Manami, Kojima Takaaki, Maturana Andres D., Kuroda Shun'ichi, Niimi Tomoaki
JOURNAL OF BIOLOGICAL CHEMISTRY
Vol.
294
(
12
)
page：
4693
-
4703
2019.3
-
pH依存的な結合性を示す軸索ガイダンス分子群の探索解析
新美友章
メディカル・サイエンス・ダイジェスト
Vol.
51
(
3
)
page：
48
-
49
2025.2
-
骨形成を促進する新奇因子NELL1の骨誘導分子基盤の解明
新美友章
Precision Medicine
Vol.
4
(
9
)
page：
884
-
886
2021.8
-
骨形成を促進する新奇因子NELL1の骨誘導分子基盤の解明
新美友章
メディカル・サイエンス・ダイジェスト
Vol.
47
(
2
)
page：
106
-
107
2021.2
-
RBM20 Regulates CaV1.2 Surface Expression by Promoting Exon 9*Inclusion of <i>CACNA1C</i> in Neonatal Rat Cardiomyocytes
Morinaga, A; Ito, J; Niimi, T; Maturana, AD
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Vol.
20
(
22
)
2019.11
-
Scaffold protein Enigma Homolog activates CREB whereas a short splice variant prevents CREB activation in cardiomyocytes.
Ito, J., Iijima, M., Yoshimoto, N., Niimi, T., Kuroda, S., Maturana, A. D.
Cell. Signal.
Vol.
27
page：
2425-2433
2015.12
-
Mapping the heparin-binding site of the osteoinductive protein NELL1 by site-directed mutagenesis.
Reviewed
Takahashi, K., Imai, A., Iijima, M., Yoshimoto, N., Maturana, A. D., Kuroda, S., and Niimi, T.
FEBS Letters
Vol.
589
page：
4026-4032
2015.12
-
Intracellular trafficking of bio-nanocapsule-liposome complex: Identification of fusogenic activity in the pre-S1 region of hepatitis B virus surface antigen L protein.
Reviewed
Somiya, M., Sasaki, Y., Matsuzaki, T., Iijima, M., Yoshimoto, N., Niimi, T., Maturana, A. D., and Kuroda, S.
J. Controll. Release
Vol.
212
page：
10-18
2015.8
-
One-step scalable preparation method for non-cationic liposomes with high siRNA content.
Reviewed
Somiya, M., Yamaguchi, K., Liu, Q., Niimi, T., Maturana, A. D., Iijima, M., Yoshimoto, N., and Kuroda, S.
Int. J. Pharm.
Vol.
490
page：
316-323
2015.7
-
Virosomes of hepatitis B virus envelope L proteins containing doxorubicin: synergistic enhancement of human liver-specific anti-tumor growth activity by radiotherapy.
Reviewed
Liu, Q., Jung, J., Somiya, M., Iijima, M., Yoshimoto, N., Niimi, T., Maturana, A. D., Shin, S. H., Jeong, S.-Y., Choi, E. K., and Kuroda, S.
Int. J. Nanomedicine
Vol.
10
page：
4159-4172
2015.6
-
Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading.
Reviewed
Nakamura, Y., Hasebe, A., Takahashi, K., Iijima, M., Yoshimoto, N., Maturana, A. D., Ting, K., Kuroda, S., and Niimi, T.
J. Biol. Chem.
Vol.
289
page：
9781-9794
2014.4
-
High-throughput de novo screening of receptor agonists with an automated single-cell analysis and isolation system.
Yoshimoto, N., Tatematsu, K., Iijima, M., Niimi, T., Maturana, A. D., Fujii, I., Kondo, A., Tanizawa, K., and Kuroda, S.
Vol.
4
page：
4242
2014
-
Cell surface-fluorescence immunosorbent assay for real-time detection of hybridomas with efficient antibody secretion at the single-cell level. Anal. Chem.
Reviewed
Kida, A., Iijima, M., Niimi, T., Maturana, A. D., Yoshimoto, N., and Kuroda, S.
Anal. Chem.
Vol.
85
page：
1753-1759
2013
-
Exploring dynamics of molybdate in living animal cells by a genetically encoded FRET nanosensor.
Reviewed
Nakanishi, Y., Iida, S., Ueoka-Nakanishi, H., Niimi, T., Tomioka, R., and Maeshima, M.
PLoS One.
Vol.
8
page：
e58175
2013
-
An automated system for high-throughput single cell-based breeding.
Reviewed
Yoshimoto, N., Kida, A., Jie, X., Kurokawa, M., Iijima, M., Niimi, T., Maturana, A. D., Nikaido, I., Ueda, H. R., Tatematsu, K., Tanizawa, K., Kondo, A., Fujii, I., and Kuroda, S.
Sci. Rep.
Vol.
3
page：
1191
2013
-
Nanocapsule-based probe for evaluating the orientation of antibodies immobilized on a solid phase.
Reviewed
Iijima, M., Yoshimoto, N., Niimi, T., Maturana, A. D., and Kuroda, S.
Analyst.
Vol.
138
page：
3470-3477
2013
-
Bio-nanocapsules for signal enhancement of alkaline phosphatase-linked immunosorbent assays.
Reviewed
Iijima, M., Yamamoto, M., Yoshimoto, N., Niimi, T., and Kuroda, S.
Biosci. Biotechnol. Biochem.
Vol.
77
page：
843-846
2013
-
Nano-visualization of oriented-immobilized IgGs on immunosensors by high-speed atomic force microscopy
Iijima, M., Somiya, M., Yoshimoto, N., Niimi, T., and Kuroda, S. (2012). Nano-visualization of oriented-immobilized IgGs on immunosensors by high-speed atomic force microscopy.
Sci. Rep.
Vol.
2
page：
790
2012
-
NELL-1 promotes cell adhesion and differentiation via Integrin β1
Reviewed
Shen, J., James, A. W., Chung, J., Lee, K., Zhang, J. B., Ho, S., Lee, K. S., Kim, T. M., Niimi, T., Kuroda, S., Ting, K., and Soo
J. Cell. Biochem.
Vol.
113
page：
3620-3628
2012
-
The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin α3β1
Reviewed
Hasebe, A., Nakamura, Y., Tashima, H., Takahashi, K., Iijima, M., Yoshimoto, N., Ting, K., Kuroda, S., and Niimi, T.
FEBS Lett.
Vol.
586
page：
2500-2506
2012
-
Engineered bio-nanocapsules, hepatitis B virus surface antigen L protein particles, for in vivo active targeting to splenic dendritic cells.
Reviewed
Matsuo, H., Yoshimoto, N., Iijima, M., Niimi, T., Jung, J., Jeon, S.-Y., Choi, E. K., Sewaki, T., Arakawa, T., and Kuroda, S.
Int. J. Nanomedicine.
Vol.
7
page：
3341-3350
2012
-
Targeting of polyplex to human hepatic cells by bio-nanocapsules, hepatitis B virus surface antigen L protein particles
Reviewed
Somiya, M., Yoshimoto, N., Iijima, M., Niimi, T., Dewa, T., Jung, J., and Kuroda, S.
Bioorg. Med. Chem.
Vol.
20
page：
3873-3879
2012
-
Hepatitis B virus envelope L protein-derived bio-nanocapsules: Mechanisms of cellular attachment and entry into human hepatic cells
Reviewed
Yamada, M., Oeda, A., Jung, J. Iijima, M., Yoshimoto, N., Niimi, T., Jeong, S.-Y., Choi, E. K., Tanizawa, K., and Kuroda, S.
J. Control. Release
Vol.
160
page：
322-329
2012
-
Efficient production and characterization of recombinant human NELL1 protein in human embryonic kidney 293-F cells.
Reviewed
Hasebe, A., Tashima, H., Ide, T., Iijima, M., Yoshimoto, N., Ting, K., Kuroda, S., and Niimi, T.
Mol. Biotechnol.
Vol.
51
page：
58-66
2012
-
Nanocapsules incorporating IgG Fc-binding domain derived from Staphylococcus aureus protein A for displaying IgGs on immunosensor chips
Reviewed
Iijima, M., Kadoya, H., Hatahira, S., Hiramatsu, S., Jung, G., Martin, A., Quinn, J., Jung, J., Jeong, S. Y., Choi, E. K., Arakawa, T., Hinako, F., Kusunoki, M., Yoshimoto, N., Niimi, T., Tanizawa, K., and Kuroda, S.
Biomaterials
Vol.
32
page：
1455-1464
2011
-
Fluorophore-labeled nanocapsules displaying IgG Fc-binding domains for the simultaneous detection of multiple antigens.
Reviewed
Iijima, M., Matsuzaki, T., Yoshimoto, N., Niimi, T., Tanizawa, K., and Kuroda, S.
Biomaterials
Vol.
32
page：
9011-9020
2011
-
Efficient and rapid purification of drug- and gene-carrying bio-nanocapsules, hepatitis B virus surface antigen L particles, from Saccharomyces cerevisiae
Reviewed
Jung, J., Iijima, M., Yoshimoto, N., Sasaki, M., Niimi, T., Tatematsu, K., Jeong, S.-Y., Choi, E. K., Tanizawa, K., and Kuroda, S.
Protein Expr. Purif.
Vol.
78
page：
149-155
2011
-
Hepatic stellate cells stimulate HCC cell migration via laminin-5 production
Reviewed
Santamato, A., Fransvea, E., Dituri, F., Caligiuri, A., Quaranta, M., Niimi, T., Pinzani, M., Antonaci, S., and Giannelli, G.
Clin. Sci.
Vol.
121
page：
159-168
2011
-
*The production of recombinant human laminin-332 in a Leishmania tarentolae expression system
Reviewed
Phan, H.P., Sugino, M. and Niimi, T.
Protein Expr. Purif.
Vol.
68
page：
79-84
2009
-
Novel Culture System of Mesenchymal Stromal Cells from Human Subcutaneous Adipose Tissue
Reviewed
Iwashima, S., Ozaki, T., Maruyama, S., Saka, Y., Kobori, M., Omae, K., Yamaguchi, H., Niimi, T., Toriyama, K., Kamei, Y., Torii, S., Murohara, T., Yuzawa, Y., Kitagawa, Y. and Matsuo, S.
Stem Cells Dev.
Vol.
18
page：
533-543
2009
-
Expression of secretoglobin3A2 (SCGB3A2) in primary pulmonary carcinomas
Reviewed
Tachihara-Yoshikawa, M., Ishida, T., Watanabe, K., Sugawara, A., Kanazawa, K., Kanno, R., Suzuki, T., Niimi, T., Kimura, S. and Munakata, M.
Fukushima J. Med. Sci.
Vol.
54
page：
61-72
2008
-
*Expression and chain assembly of human laminin-332 in an insect cell-free translation system
Reviewed
Phan, H.-P., Ezure, T., Ito, M., Kadowaki, T., Kitagawa, Y., and Niimi, T.
Biosci. Biotechnol. Biochem.
Vol.
72
page：
1847-1852
2008
-
Cryptic fragment alpha4 LG4-5 derived from laminin alpha4 chain inhibits de novo adipogenesis by modulating the effect of fibroblast growth factor-2
Reviewed
Yamashita, H., Goto, C., Tajima, R., Koparal, A. T., Kobori, M., Ohki, K., Shitara, K., Narita, R., Toriyama, K., Torii, S., Niimi, T., and Kitagawa, Y.
Develop. Growth Differ.
Vol.
50
page：
97-107
2008
-
*Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells
Reviewed
Yano, K., Imaeda, T., and Niimi, T.
Am. J. Physiol. Gastrointest. Liver Physiol.
Vol.
294
page：
G336-G343
2008
-
Identification and expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells
Reviewed
Niimi, T., Kurotani, R., Kimura, S., and Kitagawa, Y.
Biochem. Biophys. Res. Commun.
Vol.
349
page：
588-596
2006
-
The Sp family of transcription factors regulates the human laminin alpha 1 gene in JAR choriocarcinoma cells
Reviewed
Niimi, T., Hayashi, Y., Sekiguchi, K., and Kitagawa, Y.
Biochim. Biophys. Acta.
Vol.
1759
page：
573-579
2006
-
Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13
Reviewed
Yamada, A., Sheikh, F., Niimi, T., DeMayo, F. J., Keegan, A. D., Donnelly, R. P., Kimura, S.
J. Immunol.
Vol.
175
page：
5708-5715
2005
-
SOX7 and SOX17 regulate the parieetal endoderm-specific enhancer activity of mouse laminin a1 gene
Reviewed
Niimi, T., Hayashi, Y., Futaki, S., and Sekiguchi, K.
J. Biol. Chem
Vol.
279
(
36
)
page：
38055-38061
2004
-
Identification of an upstream enhancer in the mouse laminin alpha1 gene defining its high level of expression in parietal endoderm cells
Reviewed
Niimi, T. Hayashi, Y., and Sekiguchi, K.
J. Biol. Chem.
Vol.
14
page：
9332-9338
2003
-
A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma
Reviewed
Niimi, T., Munakata, M., Keck-Waggoner, C. L., Popescu, N. C., Levitt, R. C., Hisada, M., and Kimura, S.
Am. J. Hum. Genet.
Vol.
70
page：
718-725
2002
-
Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family
Reviewed
Niimi, T., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Srisodsai, A., Zimonjic, D. B., Keck-Waggoner, C. L., Popescu, N. C., and Kimura, S.
Cytogenet. Genome Res.
Vol.
97
page：
120-127
2002
-
claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung-and stomach-specific isoforms through alternative splicing
Reviewed
Niimi, T., Nagashima, K., Ward, J. M., Minoo, P., Zimonjic, D. B., Popescu, N. C., and Kimura, S.
Mol. Cell. Biol.
Vol.
21
page：
7380-7390
2001
-
UGRP1, a uteroglobin/clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP?NKX2.1 homeodomain transcription factor
Reviewed
Niimi, T., Keck-Waggoner, C. L., Popescu, N. C., Zhou, Y., Levitt, R. C., and Kimura, S.
Molecular Endocrinology
Vol.
15
page：
2021-2036
2001
-
A drosophila gene encoding multiple splice variants of Kazal-type serine protease inhibitor-like proteins with potential destinations of mitochondria, cytosol and the secretory pathway
Reviewed
Niimi, T., Yookoyama, H., Goto, A., Beck, K., and Kitagawa, Y.
Eur. J. Biochem.
Vol.
266
page：
282-292
1999
-
Brachyury (T) expression in embryonal carcinoma P19 cells resembles its expression in primitive streak and tail-bud but not that in notochord
Reviewed
Yamaguchi, H., Niimi, T., Kitagawa, Y., and Miki, K.
Develop. Growth Differ.
Vol.
41
page：
253-264
1999
-
Differential expression of mRNAs encoding laminin chain variants during in vitro development of mouse blastocysts
Reviewed
Azimi, M., Niimi, T., Yoshida, N., and Kitagawa, Y.
Cytotechnology
Vol.
31
page：
183-191
1999
-
多様なラミニン分子の形成機構
新美友章、熊谷知乃、北川泰雄
生体の科学
Vol.
48
page：
260-267
1997
-
Differentiation-dependent expression of laminin-8 (alpha4beta1gamma1) mRNAs in mouse 3T3-L1 adipocytes
Reviewed
Niimi, T., Kumagai, C., Okano, M., and Kitagawa, Y.
Matrix Biology
Vol.
16
page：
223-230
1997
-
Expression of the long arm sequence of mouse laminin alpha1, beta1, or gamma1 chain in COS1 cells and assembly of monkey-mouse hybrid laminin
Reviewed
Niimi, T., Miki, K., and Kitagawa, Y.
J. Biochem
Vol.
121
page：
854-861
1997
-
Distinct roles of mouse laminin beta1 long arm domains for alpha1beta1gamma1 trimer formation
Reviewed
Niimi, T. and Kitagawa, Y.
FEBS Letters
Vol.
400
page：
71-74
1997
-
alpha-へリックス鎖間会合の特異性と互換性-ラミニン異型体の形成機構を中心に-
北川泰雄、新美友章、熊谷知乃、岡野正樹
生物物理
Vol.
35
page：
63-69
1995
-
Regulated expression of an osteonectin variant in bovine aortic endothelial cells
Reviewed
Jeon, H., Niimi, T., Taniguchi, Y., Miki, K., and Kitagawa, Y.
Biosci. Biotech. Biochem.
Vol.
58
(
10
)
page：
1889-1891
1994
-
The protective role of polyphenols in cytotoxicity of hydrogen peroxide
Reviewed
Nakayama, T., Niimi, T., Osawa, T., and Kawakishi, S.
Mutation Research
Vol.
281
page：
77-80
1992
