論文 - 塚田　光

Effect of estradiol and nonylphenol on mRNA levels of vitellogeninII in the liver of chicken embryos.

"Sakimura M., Hanazawa S., Tsukada A., Yamamoto I., Saito N., Usami M., Ohno Y., Shimada K."

J. Poult. Sci.   38 巻   頁： 250-257   2001年1月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Effects of thyroid hormone on serum insulin-like growth factor binding proteins (IGFBPs) and IGFBP-2 mRNA expression in chickens. 査読有り

"Akira Tsukada, Takeshi Ohkubo, Minoru Tanaka, Kunio Nakashima, Masaaki Wakita and Sadao Hoshino"

Japanese poultry science   36 巻   頁： 155-166   1999年5月

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Cloning and expression of pigeon groth hormone receptor cDNA in COS-7 monkey kidney cells1. 査読有り

"Takeshi Ohkubo, Akira Tsukada, Minoru Tanaka and Kunio Nakashima"

Comparative Biochemistry and Physiology part B.   120 巻   頁： 449-455   1998年7月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Thyroid hormones are involved in insulin-like growth factor-I (IGF-I) production by stimulating hepatic growth hormone receptor (GHR) gene expression in the chicken. 査読有り

Akira Tsukada, Takeshi Ohkubo, Kesami Sakaguchi, Minoru Tanaka, Kunio Nakashima, Yukinobu Hayashida, Masaaki Wakita and Sadao Hoshino

Growth hormone and IGF research   8 巻   頁： 235-242   1998年6月

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Effect of thyroid status on IGF-I production in growing chickens was studied. Serum concentrations of GH were not affected by propylthiouracil (PTU) or thyroxine (T4) treatments, whereas serum IGF-I levels were significantly decreased in PTU-treated chickens. The lowered serum IGF-I levels in the PTU-treated group were completely restored to the control levels by T4 injections. In the liver, the messenger RNA (mRNA) expressions both for GH receptor (GHR) and IGF-I were significantly repressed by PTU treatment, and were restored again by T4 replacement. In addition, the results of analysis on radiolabelled GH binding to the liver membrane were consistent with the levels of hepatic GHR mRNA expression. Serum concentrations of IGF-I were positively correlated with hepatic IGF-I mRNA and GHR mRNA expressions. The correlation coefficient between serum T3 levels and hepatic IGF-I mRNA expressions was also significant. These results indicate that thyroid hormones regulate IGF-I production in the chicken by affecting hepatic GHR expression.