Updated on 2024/04/03

写真a

 
NISHIKAWA, Toshio
 
Organization
Graduate School of Bioagricultural Sciences Department of Applied Biosciences Professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences
Title
Professor
Contact information
メールアドレス
External link

Degree 2

  1. 博士(農学) ( 1995.1   名古屋大学 ) 

  2. 農学修士 ( 1987.3   名古屋大学 ) 

Research Interests 4

  1. Synthetic organic chemistry

  2. Natural product chemistry

  3. 天然物合成

  4. ケミカルバイオロジー

Research Areas 3

  1. Others / Others  / Organic Synthesis

  2. Others / Others  / Natural Product Chmeistry

  3. Others / Others  / Bioorganic Chemistry

Current Research Project and SDGs 6

  1. 特異な構造と強力な生物活性を示す多官能性生理活性物質の化学合成

  2. Chemical Synthesis of specific inhibitor of Na channel, Tetrodotoxin.

  3. 微量糖鎖成分C-mannnosyltryptophanの化学合成と生物有機化学

  4. New C-glycosidations and its application to the synthesis of biologically important natural products

  5. キノコの成分の化学合成

  6. ネコのまたたび反応の解明

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Research History 7

  1. Professor, Graduate school of Bioagricultural Scienences, Nagoya University   Professor

    2008.4

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    Country:Japan

  2. Associate Professor, Graduate School of Bioagricultural Sciences, Nagoya University   Associate professor

    2007.4 - 2008.3

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    Country:Japan

  3. 名古屋大学大学院生命農学研究科   助教授

    2005.4 - 2007.3

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    Country:Japan

  4. JSTさきがけ研究「合成と制御」領域研究員   JSTさきがけ研究「合成と制御」領域研究員

    2002.11 - 2006.3

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    Country:Japan

  5. Univeristy of Stuttgart

    1999.7 - 2000.6

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    Country:Germany

  6. 名古屋大学農学部   助手

    1988.1 - 2005.3

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    Country:Japan

  7. サッポロビール(株)応用開発研究所 研究員

    1987.4 - 1988.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Agriculture

    - 1987

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    Country: Japan

  2. Shizuoka University   Faculty of Science   Department of Chemistry

    - 1985

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    Country: Japan

Professional Memberships 7

  1. Japan Society for Bioscience, Biotechnolgy, and Agrochemistry

  2. The Society of Synthetic Organic Chemistry, Japan.

  3. Japan Chemical Society

  4. International Society of Heterocylic Chemistry

  5. American Chemical Society

  6. 日本ケミカルバイオロジー学会

  7. 日本プロセス化学会

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Committee Memberships 6

  1. 日本農芸化学会中部支部   支部長  

    2023.4 - 2025.3   

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    Committee type:Academic society

  2. 日本農芸化学会中部支部   副支部長  

    2021.4 - 2023.3   

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    Committee type:Academic society

  3. 有機合成化学協会   カネカ生命科学賞選考委員  

    2020.4   

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    Committee type:Academic society

  4. 有機合成化学協会   有機合成化学協会誌編集委員長  

    2020.4 - 2021.3   

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    Committee type:Academic society

    委員長

  5. 日本化学会   化学会賞受賞選考委員  

    2014 - 2015   

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    Committee type:Academic society

  6. 日本化学会   Chemistry Letters 編集委員  

    2009 - 2011   

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    Committee type:Academic society

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Awards 9

  1. 平成29 年度有機合成化学協会 シオノギ•低分子創薬化学賞

    2018.2   有機合成化学協会  

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

  2. Lectureship Awards at the 0th conference on Cutting-Edge Organic Chemitry in Asia (Hong-Kong)

    2011   ICCEOCA  

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    Country:Japan

  3. Lectureship Awards at the 0th conference on Cutting-Edge Organic Chemitry in Asia (Taiwan)

    2009.12   Asian Core program organizing Committie  

  4. Lectureship Awards at the 0th conference on Cutting-Edge Organic Chemistry in Asia (Taiwan)

    2006.3   Asian Core program organizing Committie  

  5. Synlett Assistant Professor Award 2004

    2004   Thieme Synlett editorial board  

  6. 有機合成化学奨励賞

    2002.2   社団法人有機合成化学協会  

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    Country:Japan

  7. 第13回(2000年)有機合成化学協会『研究企画賞』

    2001.2   有機合成化学協会  

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    Country:Japan

  8. Specs and BioSpecs ポスター賞

    2001.8   18th International Congress of Heterocyclic Chemistry  

  9. 第20回農芸化学研究企画賞「ネコのマタタビ反応の研究から着想した蚊の忌避剤の開発」

    2023.1   日本農芸化学会   「ネコのマタタビ反応の研究から着想した蚊の忌避剤の開発」

    西川俊夫

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Papers 160

  1. Collective Synthesis of Aplysiatoxin/Oscillatoxin Analogues by a Bioinspired Strategy. Reviewed

    Hada K, Araki Y, Nokura Y, Urabe D, Nishikawa T

        2022.11

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.2c02204

    PubMed

  2. An almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an odorant for the grass puffer. Reviewed

    Noguchi Y, Suzuki T, Matsutani K, Sakakibara R, Nakahigashi R, Adachi M, Nishikawa T, Abe H

    Scientific reports   Vol. 12 ( 1 ) page: 15087   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-19355-6

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  3. The characteristic response of domestic cats to plant iridoids allows them to gain chemical defense against mosquitoes. Reviewed International coauthorship

    Uenoyama R, Miyazaki T, Hurst JL, Beynon RJ, Adachi M, Murooka T, Onoda I, Miyazawa Y, Katayama R, Yamashita T, Kaneko S, Nishikawa T, Miyazaki M

    Science advances   Vol. 7 ( 4 )   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciadv.abd9135

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  4. Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium Reviewed International coauthorship

    Qi Jianhua, Cheng Lihong, Sun Yujuan, Hirata Yushi, Ushida Naoki, Ma Zhonghua, Osada Hiroyuki, Nishikawa Toshio, Xiang Lan

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 57 ( 27 ) page: 8100-8104   2018.7

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201803329

    Web of Science

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  5. Biomimetic Synthesis and Structural Revision of Chaxine B and Its Analogues Reviewed

    Hirata Yushi, Nakazaki Atsuo, Kawagishi Hirokazu, Nishikawa Toshio

    ORGANIC LETTERS   Vol. 19 ( 3 ) page: 560-563   2017.2

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.6b03724

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  6. Total Synthesis of Chiriquitoxin, an Analogue of Tetrodotoxin Isolated from the Skin of a Dart Frog Reviewed

    Adachi, M.; Imazu, T.; Sakakibara, R.; Satake, Y.; Isobe, M.; Nishikawa, T.

    Chem. Eur. J.   Vol. 20   page: 1247-1251   2014

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.201304110

  7. A Synthetic Route of the Saxitoxin Skeleton: Synthesis of Decarbamoyl-α-saxitoxinol, an Analog of Saxitoxin Produced by the Cyanobacterium Lyngbya wollei Reviewed

    Angew. Chem. Int. Ed   Vol. 50   page: 7176-7178   2011

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  8. *Synthetic Studies and biosynthetic speculation on marine alkaloid chartelline Reviewed

    S. Kajii, T. Nishikawa, M. Isobe

    Chem. Commun.     page: 3121-3123   2008

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  9. *An Efficient Total Synthesis of Optically Active Tetrodotoxin from Levoglucosenone Reviewed

    51. Urabe, D.; Nishikawa, T.; Isobe, M.

    Chemistry, An Asian Journal   Vol. 1   page: 125-135   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  10. The First Asymmetric Total Synthesis of Tetrodotoxin Reviewed

    Ohyabu, N.; Nishikawa, T.; Isobe, M.

    Journal of American Chemical Society   Vol. 125   page: 8798-8805   2003

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  11. Asymmetric Total Synthesis of 11-Deoxytetrodotoxin

    "Nishikawa, T.; Asai, M.; Isobe, M."

    Journal of the American Chemical Society   Vol. 124   page: 7847-7852   2002.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  12. Stereocotrolled Synthesis of (-)-5.11-dideoxytetrodotoxin. Reviewed

    Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Isobe, M.

    Angewandte Chemie International Edition   Vol. 38   page: 3081-3084   1999

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    Language:English   Publishing type:Research paper (scientific journal)  

  13. 5, 6, 11-trideoxy tetrodotoxin attracts tiger puffer Takifugu rubripes. Reviewed

    Miyazaki K, Suo R, Itoi S, Hirota J, Adachi M, Miyasaka T, Nishikawa T, Yokoyama T, Sato S, Takada K

    Toxicon : official journal of the International Society on Toxinology   Vol. 237   page: 107539   2024.1

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    Language:English  

    DOI: 10.1016/j.toxicon.2023.107539

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  14. Distribution of tetrodotoxin and its analogs in the toxic flatworm Planocera multitentaculata from Honshu Island, Japan Reviewed

    Suo, R.; Tanaka, M.; Asano, M.; Nakahigashi, R.; Adachi, M.; Nishikawa, T.; Ogiso, S.; Matsubara, H.; Suzuki, N.; Itoi, S.

    Fisheries Science   Vol. 20   2024

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1007/s12562-024-01754-5

  15. Total Synthesis of 19-Nordigitoxigenin, An Antiaroside Y Aglycon. Reviewed

    Matsumura T, Nishikawa T, Nakazaki A

    The Journal of organic chemistry   Vol. 88 ( 21 ) page: 15142 - 15150   2023.11

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    Language:English  

    DOI: 10.1021/acs.joc.3c01629

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  16. Assessing the safety and suitability of using silver vine as an olfactory enrichment for cats. Reviewed International coauthorship

    Uenoyama R, Ooka S, Miyazaki T, Mizumoto H, Nishikawa T, Hurst JL, Miyazaki M

    iScience   Vol. 26 ( 10 ) page: 107848   2023.10

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    DOI: 10.1016/j.isci.2023.107848

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  17. Geographical differences in the composition of tetrodotoxin and 5,6,11-trideoxytetrodotoxin in Japanese pufferfishes and their origins. Reviewed

    Ito M, Shirai K, Oyama H, Yasukawa S, Asano M, Kihara M, Suo R, Sugita H, Nakahigashi R, Adachi M, Nishikawa T, Itoi S

    Chemosphere   Vol. 336   page: 139214   2023.9

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  18. The Asymmetric Total Synthesis and Configuration Confirmation of Aplysiaenal and Nhatrangin A, Truncated Derivatives of Aplysiatoxin and Oscillatoxin. Reviewed

    Morishita M, Hada K, Kita M, Nishikawa T

    Journal of natural products   Vol. 86 ( 4 ) page: 1033 - 1041   2023.4

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jnatprod.3c00077

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  19. Levels of Tetrodotoxins in Spawning Pufferfish, Takifugu alboplumbeus. Reviewed

    Asano M, Ishizaki C, Tomonou T, Kihara M, Ito M, Yasukawa S, Shirai K, Oyama H, Izawa S, Kawamura R, Saito K, Suo R, Nakahigashi R, Adachi M, Nishikawa T, Sugita H, Itoi S

    Marine drugs   Vol. 21 ( 4 )   2023.3

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    Language:English  

    DOI: 10.3390/md21040207

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  20. An Asymmetric Total Synthesis of Picrotoxinin through a Mizoroki–Heck Reaction Reviewed

    Matsumura, T.; Nishikawa, T.; Nakazaki, A.

      Vol. 34   2023

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/a-1981-4489

  21. A Convergent Synthesis of Tetracyclic Indole Compounds by a Palladium-Catalyzed Cross-Coupling and Tandem Cyclization Reaction Reviewed

    Ono, Y.; Higuchi, K.; Yamaguchi, M.; Sugino, K.; Nakazaki, A.; Adachi, M.; Nishikawa, T.

    Synlett   Vol. 34   page: 364 - 368   2023

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0042-1751396

  22. 7-Epi-30-Methyloscillatoxin D from an Okinawan Cyanobacterium Okeania hirsuta Reviewed International coauthorship

    Kanda, N.; Zhang, B-T.; Shinjo, A.; Kamiyama, M.; Nagai, H.; Uchida, H.; Araki, Y.; Nishikawa, T.; Satake, M.

    Natural Product Communications   Vol. 18   page: 1 - 5   2023

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1934578X231173799

  23. Changes in Tissue Distribution of Tetrodotoxin and Its Analogues in Association with Maturation in the Toxic Flatworm, Planocera multitentaculata. Reviewed International coauthorship

    Oyama H, Ito M, Suo R, Goto-Inoue N, Morisasa M, Mori T, Sugita H, Mori T, Nakahigashi R, Adachi M, Nishikawa T, Itoi S

    Marine biotechnology (New York, N.Y.)     2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10126-022-10179-z

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  24. Tetrodotoxins in the flatworm Planocera multitentaculata.

    Suo R, Tanaka M, Oyama H, Kojima Y, Yui K, Sakakibara R, Nakahigashi R, Adachi M, Nishikawa T, Sugita H, Itoi S

    Toxicon : official journal of the International Society on Toxinology   Vol. 216   page: 169 - 173   2022.9

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    DOI: 10.1016/j.toxicon.2022.07.001

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  25. Structural verification of petromyzestrosterol by total syntheses of both C14-epimers of its 3-<i>O</i>-methyl derivative. Reviewed

    Nakazaki A, Kawai M, Nishikawa T

    Organic & biomolecular chemistry   Vol. 20 ( 32 ) page: 6432 - 6435   2022.8

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d2ob01047j

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  26. Total Syntheses of the Proposed Biosynthetic Intermediates of Tetrodotoxin Tb-210B, Tb-226, Tb-242C, and Tb-258. Reviewed

      Vol. 87 ( 14 ) page: 9023 - 9033   2022.7

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.2c00704

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  27. Domestic cat damage to plant leaves containing iridoids enhances chemical repellency to pests. Reviewed International coauthorship

    Uenoyama R, Miyazaki T, Adachi M, Nishikawa T, Hurst JL, Miyazaki M

    iScience   Vol. 25 ( 7 ) page: 104455   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2022.104455

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  28. Local Differences in the Toxin Amount and Composition of Tetrodotoxin and Related Compounds in Pufferfish (<i>Chelonodon patoca</i>) and Toxic Goby (<i>Yongeichthys criniger</i>) Juveniles. Reviewed International coauthorship

    Ito M, Furukawa R, Yasukawa S, Sato M, Oyama H, Okabe T, Suo R, Sugita H, Takatani T, Arakawa O, Adachi M, Nishikawa T, Itoi S

    Toxins   Vol. 14 ( 2 )   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/toxins14020150

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  29. Green spotted puffers detect a nontoxic TTX analog odor using crypt olfactory sensory neurons. Reviewed

    Suzuki T, Nakahigashi R, Adachi M, Nishikawa T, Abe H

    Chemical senses   Vol. 47   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/chemse/bjac011

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  30. The Synthesis of simplified analogues of crambescin B carboxylic acid and their inhibitory activity of voltage-gated sodium channels: new aspects of atructure-activity relationships. Reviewed

    Nakazaki, A.; Mouri, S.; Nakane, Y.; Ishikawa, Y.; Yamashira,M.; Nishikawa, T.

    Heterocycles     2022

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

  31. Synthesis of the 8-Deoxy Analogue of 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a Proposed Biosynthetic Precursor of Tetrodotoxin. Reviewed

    Miyasaka T, Adachi M, Nishikawa T

    Organic letters   Vol. 23 ( 23 ) page: 9232 - 9236   2021.12

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.1c03565

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  32. Total synthesis and biological evaluation of oscillatoxins D, E, and F. Reviewed

    Araki Y, Hanaki Y, Kita M, Hayakawa K, Irie K, Nokura Y, Nakazaki A, Nishikawa T

    Bioscience, biotechnology, and biochemistry   Vol. 85 ( 6 ) page: 1371 - 1382   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bbb/zbab042

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  33. Total Synthesis of the Cardiotonic Steroid (+)-Cannogenol. Reviewed

    Watanabe S, Nishikawa T, Nakazaki A

    The Journal of organic chemistry   Vol. 86 ( 4 ) page: 3605 - 3614   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.0c02966

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  34. Biomimetic Synthesis of the CDE Ring Moiety of Physalins, Complex 13,14-Secosteroids. Reviewed

    Araki Y, Nakazaki A, Nishikawa T

    Organic letters   Vol. 23 ( 3 ) page: 989 - 994   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.0c04198

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  35. First Detection of Tetrodotoxins in the Cotylean Flatworm <i>Prosthiostomum trilineatum</i>. Reviewed

    Suo R, Kashitani M, Oyama H, Adachi M, Nakahigashi R, Sakakibara R, Nishikawa T, Sugita H, Itoi S

    Marine drugs   Vol. 19 ( 1 )   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/md19010040

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  36. Synthesis of the 8-Deoxy Analogue of 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a Proposed Biosynthetic Precursor of Tetrodotoxin. Reviewed

    (1) Miyasaka, T.; Adachi, M.; Nishikawa, T.

    Org. Lett.   Vol. 23   page: 9232 - 9236   2021

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1021/acs.orglett.1c03565

  37. Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions. Reviewed

    Hanaki, Y., Araki, Y., Nishikawa, T., Yanagita, R. C.

    Fundam. Toxicol. Sci.   Vol. 8 ( 3 ) page: 69 - 73   2021

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.2131/fts.8.69

  38. Total Synthesis and biological evaluation of oscillatoxins D, E, and F. Reviewed

    Araki, Y.; Hanaki, Y.; Kita, M.; Hayakawa, K.; Irie, K.; Nokura, Y.; Nakazaki, A.; Nishikawa, T.

    Biosci. Biotechnol. Biochem.   Vol. 85 ( 6 ) page: 1371 - 1382   2021

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1093/bbb/zbab042

  39. Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines. Reviewed

    Hanaki, Y., Araki, Y., Nishikawa, T., Yanagita, R. C.

    Heterocycles   Vol. 102 ( 12 ) page: 2353 - 2362   2021

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  40. Biosynthesis of Indole Diterpene Lolitrems: Radical-Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton. Reviewed

    Jiang Y, Ozaki T, Harada M, Miyasaka T, Sato H, Miyamoto K, Kanazawa J, Liu C, Maruyama JI, Adachi M, Nakazaki A, Nishikawa T, Uchiyama M, Minami A, Oikawa H

    Angewandte Chemie (International ed. in English)   Vol. 59 ( 41 ) page: 17996 - 18002   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.202007280

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  41. Studies toward the Synthesis of Chartelline C. Reviewed

    Nakane Y, Nakazaki A, Nishikawa T

    The Journal of organic chemistry   Vol. 85 ( 11 ) page: 7534 - 7542   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.0c00643

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  42. New Synthetic Method for Efficient Synthesis of Bioactive Natural Products -Biomimetic Synthesis of Chaxines- Reviewed

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   Vol. 78 ( 6 ) page: 566 - 574   2020.6

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    Web of Science

  43. Biomimetic Synthesis of Chaxine and its Related Compounds. Reviewed

    Niki M, Hirata Y, Nakazaki A, Wu J, Kawagishi H, Nishikawa T

    The Journal of organic chemistry   Vol. 85 ( 7 ) page: 4848 - 4860   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.9b03482

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  44. Synthesis of Oxy-Functionalized Steroidal Skeletons via Mizoroki-Heck and Intramolecular Diets-Alder Reactions Reviewed

    Watanabe Shogo, Nishikawa Toshio, Nakazaki Atsuo

    ORGANIC LETTERS   Vol. 21 ( 18 ) page: 7410 - 7414   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.orglett.9b02716

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  45. Asymmetric Synthesis of the Aromatic Fragment of Sespendole Reviewed

    Ono Yoshiki, Nakazaki Atsuo, Ueki Kaori, Higuchi Keiko, Sriphana Uraiwan, Adachi Masaatsu, Nishikawa Toshio

    JOURNAL OF ORGANIC CHEMISTRY   Vol. 84 ( 15 ) page: 9750 - 9757   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.9b01597

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  46. Concise Stereocontrolled Synthesis of an alpha-Carbagalactose Segment of RCAI-56, a Candidate Anticancer Agent Reviewed

    Ushida Naoki, Nagai Nobukazu, Adachi Masaatsu, Nishikawa Toshio

    SYNLETT   Vol. 30 ( 8 ) page: 977-981   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/s-0037-1611806

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  47. Total Syntheses and Determination of Absolute Configurations of Cep-212 and Cep-210, Predicted Biosynthetic Intermediates of Tetrodotoxin Isolated from Toxic Newt Reviewed

    Adachi Masaatsu, Miyasaka Tadachika, Kudo Yuta, Sugimoto Keita, Yotsu-Yamashita Mari, Nishikawa Toshio

    ORGANIC LETTERS   Vol. 21 ( 3 ) page: 780 - 784   2019.2

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    DOI: 10.1021/acs.orglett.8b04043

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  48. A concise synthesis of peramine, a metabolite of endophytic fungi.

    Ito S, Yamamoto Y, Nishikawa T

    Bioscience, biotechnology, and biochemistry   Vol. 82 ( 12 ) page: 2053 - 2058   2018.12

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    DOI: 10.1080/09168451.2018.1511966

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  49. Toward a Synthesis of Fawcettimine-Type Lycopodium Alkaloids: Stereocontrolled Synthesis of a Functionalized Azaspirocycle Precursor

    Huang Wen-Yu, Nishikawa Toshio, Nakazaki Atsuo

    JOURNAL OF ORGANIC CHEMISTRY   Vol. 83 ( 18 ) page: 11108 - 11117   2018.9

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    DOI: 10.1021/acs.joc.8b01719

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  50. Semi-synthesis and Structure-Activity Relationship of Neuritogenic Oleanene Derivatives

    Bian Linglin, Cao Shining, Cheng Lihong, Nakazaki Atsuo, Nishikawa Toshio, Qi Jianhua

    CHEMMEDCHEM   Vol. 13 ( 18 ) page: 1972-1977   2018.9

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    DOI: 10.1002/cmdc.201800352

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  51. SYNTHESIS OF DIBROMO COMPOUNDS CONTAINING 2,6-DIOXABICYCLO[3.1.1]HEPTANE SIMILAR TO CORE MOIETY OF THROMBOXANE A(2)

    Nokura Yoshihiko, Nakazaki Atsuo, Nishikawa Toshio

    HETEROCYCLES   Vol. 96 ( 1 ) page: 127-136   2018.1

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    DOI: 10.3987/COM-17-13814

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  52. Spiro Bicyclic Guanidino Compounds from Pufferfish: Possible Biosynthetic Intermediates of Tetrodotoxin in Marine Environments.

    113. Ueyama, N.; Sugimoto, K.; Kudo, Y.; Onodera, K.; Cho, Y.; Konoki, K.; Nishikawa, T.; Yotsu-Yamashita, M.

    Chem. Eur. J.   Vol. 24   page: 7250 – 7258   2018

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  53. Synthetic Route to Oscillatoxin D and Its Analogues

    Nokura Yoshihiko, Araki Yusuke, Nakazai Atsuo, Nishikawa Toshio

    ORGANIC LETTERS   Vol. 19 ( 21 ) page: 5992 - 5995   2017.11

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    DOI: 10.1021/acs.orglett.7b03032

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  54. Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Na(v)1.1 to Na(v)1.7)

    Tsukamoto Tadaaki, Chiba Yukie, Wakamori Minoru, Yamada Tomoshi, Tsunogae Shunsuke, Cho Yuko, Sakakibara Ryo, Imazu Takuya, Tokoro Shouta, Satake Yoshiki, Adachi Masaatsu, Nishikawa Toshio, Yotsu-Yamashita Mari, Konoki Keiichi

    BRITISH JOURNAL OF PHARMACOLOGY   Vol. 174 ( 21 ) page: 3881-3892   2017.11

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    DOI: 10.1111/bph.13985

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  55. Concise Synthesis of a Cyclopentane Intermediate Possessing All Nitrogen Functionalities for Pactamycin

    Matsumoto Nobuyuki, Nakazaki Atsuo, Nishikawa Toshio

    SYNLETT   Vol. 28 ( 17 ) page: 2303-2306   2017.10

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    DOI: 10.1055/s-0036-1588495

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  56. De Novo Synthesis of Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor

    Nakazaki Atsuo, Hashimoto Keiko, Ikeda Ai, Shibata Takahiro, Nishikawa Toshio

    JOURNAL OF ORGANIC CHEMISTRY   Vol. 82 ( 17 ) page: 9097 - 9111   2017.9

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    DOI: 10.1021/acs.joc.7b01640

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  57. New regiocontrolled syntheses of pyrrolopyrazinones and its application to the synthesis of peramine

    Yamamoto Yuta, Nakazaki Atsuo, Nishikawa Toshio

    TETRAHEDRON   Vol. 73 ( 25 ) page: 3443-3451   2017.6

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    DOI: 10.1016/j.tet.2017.05.004

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  58. Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B

    Tsukamoto Tadaaki, Chiba Yukie, Nakazaki Atsuo, Ishikawa Yuki, Nakane Yoshiki, Cho Yuko, Yotsu-Yamashita Mad, Nishikawa Toshio, Wakamori Minoru, Konoki Keiichi

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   Vol. 27 ( 5 ) page: 1247-1251   2017.3

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    DOI: 10.1016/j.bmcl.2017.01.054

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  59. Palladium-Catalyzed Cascade Wacker/Allylation Sequence with Allylic Alcohols Leading to Allylated Dihydropyrones. Reviewed

    Huang, W.-Y.; Nishikawa, T.; Nakazaki, A.

    ACS Omega   ( 2 ) page: 487-495   2017.2

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  60. One-Step Transformation of Trichloroacetamide into Isonitrile

    Adachi Masaatsu, Miyasaka Tadachika, Hashimoto Honoka, Nishikawa Toshio

    ORGANIC LETTERS   Vol. 19 ( 2 ) page: 380-383   2017.1

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    DOI: 10.1021/acs.orglett.6b03583

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  61. Concise Synthesis of a Cyclopentane Intermediate Possessing All nitrogen Functionalities for Pactamycin. Reviewed

    Matsumoto, N.; Nakazaki, A.; Nishikawa, T.

    Synlett   Vol. 28 ( 17 ) page: 2303-2306   2017

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  62. New regiocontrolled syntheses of pyrrolopyrazinones and its application to the synthesis of peramine. Reviewed

    Yamamoto, Y.; Nakazaki, A.; Nishikawa, T.

    Tetrahedron   ( 73 ) page: 3443-3451   2017

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  63. Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B. Reviewed

    Tsukamoto, T.; Chiba, Y.; Nakazaki, A.; Ishikawa, Y.; Nakane, Y.; Cho, Y.; Nishikawa, T.; Yotsu-Yamashita, M.; Wakamori, M.; Konoki K.

    Med. Chem. Lett   ( 27 ) page: 1247-1251   2017

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  64. Biomimetic Synthesis and Structural Revision of Chaxine B and Its Analogues. Reviewed

    Hirata, Y.; Nakazaki, A.; Kawagishi, H.; Nishikawa, T.

    Org. Lett.   ( 19 ) page: 560-563   2017

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  65. A Synthetic Strategy for Saxitoxin Skeleton by a Cascade Bromocyclization: Total Synthesis of (+)-Decarbamoyl-α-saxitoxinol. Reviewed

    Ueno, S.; Nakazaki, A.; Nishikawa, T.

    Org. Lett.   ( 18 ) page: 6368-6371   2016

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  66. A Divergent Approach to the Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives. Reviewed

    Nakazaki, A.; Mori, A.; Kobayashi, S.; Nishikawa, T

    Chem. Asian J.   ( 11 ) page: 3267-3274   2016

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  67. One-pot non-enzymatic formation of firefly luciferin in a neutral buffer fromp-benzoquinone and cysteine. Reviewed

    Kanie S.; Nishikawa T.; Ojika M.; Oba Y.

    Scientific Reports   Vol. 24794 ( 6 )   2016

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    DOI: 10.1038/srep24794

  68. Asymmetric synthesis of crambescin A-C carboxylic acids and their inhibitory activity on voltage-gated sodium channels. Reviewed

    Nakazaki A.; Nakane Y.; Ishikawa Y.; Yotsu-Yamashita M.; Nishikawa T.

    Org. Biomol. Chem.   ( 14 ) page: 5304-5309   2016

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  69. Improved Syntheses of (+)-Iridomyrmecin and (-)-Isoiridomyrmecin, Major Components of Matatabilactone. Reviewed

    Adachi M.; Miyazawa Y.; Nishikawa, T.

    Natural Product Communications 2016   ( 11 ) page: 883-886   2016

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  70. Multifunctionality of the N-Trichloroacetyl Group Developed in the Synthesis of Tetrodotoxin, a Puffer Fish Toxin Reviewed

    (1) Toshio Nishikawa, Daisuke Urabe, Masaatsu Adachi, Minoru Isobe

    Synlett   Vol. 26   page: 1930-1939   2015.5

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  71. Unexpected Metal-Free Transformation of gem-Dibromomethylenes to Ketones under Acetylation Conditions. Reviewed

    Kimura, R.; Sawayama, Y.; Nakazaki, A.; Miyamoto, K.; Uchiyama, M.; Nishikawa, T.

    Chem. Asian J.   ( 10 ) page: 1035-1041   2015

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  72. Synthesis of a C-N Axially Chiral N-Aryl Isatin through Asymmetric Intramolecular N-Arylation Reviewed

    Nakazaki, A.; Miyagawa, K.; Nishikawa, T.

    Eur. J. Org. Chem.     page: 4603–4606   2015

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  73. Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from N-Aryl-3-Chlorooxindoles Reviewed

    Nakazaki, A.; Miyagawa, K.; Nishikawa, T.

    Synlett   ( 26 ) page: 1116-1120   2015

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  74. Stereocontrolled Synthesis of ABC-tricycle of Solanoeclepin A. Reviewed

    Adachi, M.; Torii, M.; Nishikawa, T.

    Synlett   ( 26 ) page: 965-969   2015

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  75. Synthesis of 1.5-dioxaspiro[3.4]octane through bromocation-induced cascade cyclization Reviewed

    Nakazaki, A.; Nakane, Y.; Ishikawa, Y.; Nishikawa, T.

    Heterocycles   Vol. 91   page: 1157-   2015

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    DOI: DOI:10.3987/COM-15-13208

  76. Synthesis of crambescin B carboxylic acid,a potent inhibitor of voltage-gated sodium channels Reviewed

    Atsuo Nakazaki, Yuki Ishikawa, Yusuke Sawayama, Mari Yotsu-Yamashita Toshio Nishikawa

    Org. Biomol. Chem.   ( 12 ) page: 53–56   2014

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  77. Synthesis of 5,6,11-Trideoxytetrodotoxin Reviewed

    Adachi M.: Sakakibara, R.; Satake, Y.; Isobe, M.; Nishikawa, T.

    Chem. Lett.   Vol. 43   page: 1719-1721   2014

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  78. A New Deprotection of MTM Ether. Reviewed

    Adachi M.; Hashimoto, H.; Sakakibara, R.; Imazu, T.; Nishikawa, T.

    Synlett     page: 2498-2502   2014

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  79. Synthesis of 5- and 8-Deoxytetrodotoxin Reviewed

    Satake, Y.: Adachi, M.; Tokoro, S.; Yotsu-Yamashita, M.; Isobe M.; Nishikawa, T.

    Chem. Asian J.   Vol. 9   page: 1922-1932   2014

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  80. An improved synthesis of (-)-5,11-Dideoxytetrodotoxin Reviewed

    Adachi, M.; Imazu, T.; Isobe, M.; Nishiakwa. T.

    J. Org. Chem.   Vol. 78   page: 1699-1705   2013

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  81. First Identification of 5,11-Dideoxytetrodotoxin in Marine Animals, and Characterization of Major Fragment Ions of Tetrodotoxin and Its Analogs by High Resolution ESI-MS/MS Reviewed

    Mari Yotsu-Yamashita, Yuka Abe, Yuta Kudo, Raphael Ritson-Williams, Valerie J. Paul,Keiichi Konoki, Yuko Cho, Masaatsu Adachi, Takuya Imazu, Toshio Nishikawa, Minoru Isobe.

    Mar. Drugs   ( 11 ) page: 2799-2813   2013

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  82. Stereocontrolled Total synthesis of Polygalolide A. Reviewed

    Yamada, H. Adachi, M.; Isobe, M.; Nishikawa, T.

    Chem. Asian J.   ( 8 ) page: 1428-1435   2013

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  83. Structure Study on a naturally Occurring Terphenyl Quinone Reviewed

    Nakazaki, A.; Huang, W-Y.; Koga K.; Yingyongnarongkul B-E.; Boonsombat J.; Sawayama Y.; Tsujimoto T.; Nishikawa, T.

    Biosci. Biotechnol. Biochem.   ( 77 ) page: 1529-1532   2013

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  84. Synthesis of Tetracyclic Indoline and Indolenine Derivatives Having β-Lactam Using Amphiphilic Reactivity of 2-Methylindolenine Reviewed

    Nakazaki, A.; Hara, Y.; Kajii, S.; Nishikawa, T

    Heterocycles   Vol. 87   page: 611-625   2013

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  85. Synthetic studies on pactamycin, a potent antitumor antibiotic Reviewed

    51. Matsumoto, N.; Tsujimoto, T.; Nakazaki, A.; Isobe M.; Nishikawa, T.

    RSC, Advances   Vol. 2   page: 9448-9462   2012

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  86. Stereocontrolled Synthesis of an Indole Moiety of Sespendole and Stereochemical Assignment of the Side Chain Reviewed

    Adachi, M.; Higuchi, K.; Thasana, N.; Yamada, H.; Nishikawa, T.

    Org. Lett.   Vol. 14   page: 144-117   2012

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  87. Bromocyclization of Alkynyl Guanidine: A New Approach to the Synthesis of Cyclic Guanidines of Saxitoxin Reviewed

        page: 651-654   2011.2

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  88. Synthetic Study on Sespendole, an Indole Sesquiterpene Alkaloid: Stereocontrolled Synthesis of the Sesquiterpene Segment Bearing All Requisite Stereogenic Centers. Reviewed

    Sugino, K.; Nakazaki, A.; Isobe, M.; Nishikawa, T.

        page: 647-650   2011.2

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  89. Dynamic Chirality Determines Critical Roles for Bioluminescence in Symplectin–Dehydrocoelenterazine System Reviewed

    68. V. Kongjinda, Y. Nakashima, N.Tani, M. Kuse, T. Nishikawa, Chin-Hui Yu, N. Harada, M. Isobe

      Vol. 6   page: 2080-2091   2011

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  90. Concise Synthesis of Deformylflustrabromine, a Marine Indole Alkaloid Through Propargyl Dicobalt Hexacarbonyl Complex Reviewed

    Isaji, H.; Nakazaki, A.; Isobe, M.; Nishikawa, T.

      Vol. 40   page: 1079-1081   2011

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  91. A New Ring Expansion for a Chiral Hexahydroazulene Skeleton Possessing an Angular Methyl Group Reviewed

    70. Adachi, M.; Komada, T.; Nishikawa, T.

    J. Org. Chem.   Vol. 76   page: 6942-6945   2011

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  92. Total Synthesis of Polygalolide A Reviewed

    Adachi, M.; Yamada, H.; Isobe,M.; Nish1ikawa, T.

    Org. Lett.   Vol. 24   page: 6532-6535   2011

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  93. Identification of a Fluorescent Compound in the Cuticle of the Train Millipede Parafontaria laminata armigera. Reviewed

    Kuse, M.; Yanagi, M.; Tanaka, E.; Tani, N.; Nishikawa, T.

    Biosci. Biotechnol. Biochem.   Vol. 74   page: 2307-2309   2010.10

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  94. Synthesis of an Advanced Intermediate Bearing Two Hydroxy Groups for (-)-Tetrodotoxin and Its Analogs Reviewed

    Nishikawa, T.; Koide, Y.; Adachi, M.; Isobe, M.

    Bull. Chem. Soc. Jpn.   Vol. 86   page: 66-68   2010

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  95. Scalable Synthesis of a New Dihydroxylated Intermediate for tetrodotoxin and Its Analogues Reviewed

    atake, Y.; Nishikawa, T.; Hiramatsu, T.; Araki, H.; Isobe, M.

    Synthesis     page: 1992-1998   2010

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  96. Syntheses of N-Acylosoxazolidine derivatives, related to a partial strycture found in zetekitoxin AB, a Golden Frog Poison Reviewed

    Nishikawa, T.; Urabe, D.; Isobe, M.

    Heterocycles   Vol. 79   page: 379-385   2009

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  97. Dehydrocoelenterazine Is the Organic Substance Constituting the Prosthetic Group of Pholasin Reviewed

    Tanaka, E.; Kuse, M.; Nishikawa, T.

    ChemBioChem,   Vol. 10   page: 2725-2729   2009

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  98. Selective Oxidation by the Hydroperoxide in the Photoprotein, Aequorin Reviewed

    12. Doi, I.; Kuse, M.; Nishikawa, T.; Isobe, M.

    Bioorg. Med. Chem.   Vol. 17   page: 3399-3404   2009

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  99. Synthesis of Four Lysine-Linked Cereulide Analogs showing K+ Ionophoric Activity as Lead Compounds for Emetic Toxin-Detection by Immunoassays. Reviewed

    Makarasen, A.; Nishikawa, T.; Isobe, M.

    Synthesis     page: 2184-2204   2009

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  100. Imino-O-Tosylate in Suzuki-Miyaura Reaction for substitution of the Pyrazine Rings: A Study for the Synthesis of Coelenterazine Analogs. Reviewed

    Makarasen, A.; Kuse, M.; Nishikawa, T.; Isobe, M.

    Bull. Chem. Soc. Jpn.   Vol. 82   page: 870-878   2009

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  101. Pholasin luminescence is enhanced by addition of dehydrocoelenterazine Reviewed

    Kuse, M.; Tanaka, E.; Nishikawa, T.

    Bioorganic & Medicinal Chemistry Letters   Vol. 18   page: 5657-5659   2008.6

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  102. Regioselectivity of Larock Indole Synthesis by Using Functionalized Alkynes Reviewed

    Sugino, K.; Yoshimura, H.; Nishikawa, T.; Isobe, M.

    Bioscience, Biotechnology & Biochemistry   Vol. 72   page: 594-597   2008.4

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  103. Synthesis of N-hydroxyenamide, a potential precursor of chertelline

    S. Kajii, T. Nishikawa, M. Isobe

    Tetrahedron Letters   Vol. 49   page: 594-597   2008

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  104. Synthesis of beta-Analogues of C-Mannosyltryptophan, a Novel C-Glycosylamino Acid Found in Proteins Reviewed

    50. Nishikawa, T.; Koide, Y.; Kanakubo, A.; Yoshimura, H.; Isobe, M.

    Organic Biochemical Chemistry   Vol. 4   page: 1268-1277   2006

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  105. Syntheses of Naturally Occurring Terphenyls and Its Related Compounds, Reviewed

    Sawayama, Y.; Tsujimoto, T.; Sugino, K.; Nishikawa, T.; Isobe., M.; Kawagishi, H

    Bioscience, Biotechnology & Biochemistry   Vol. 70 ( 12 ) page: 2998-3003   2006

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  106. *One-Pot Transformation of Trichloroacetamide into Readily Deprotectable Carbamates Reviewed

    Nishikawa, T.; Urabe, D.; Tomita, M.; Tsujimoto, T.; Iwabuchi, T.; Isobe, M.

    Organic Letters   Vol. 8   page: 3263-3265   2006

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  107. *Stereocontrolled Synthesis of alfa-C-Mannosyltryptohan and its Analogues. Reviewed

    Nishikawa, T.; Koide, Y.; Kajii, S.; Wada, K.; Ishikawa, M., Isobe, M.

    Organic Biochemical Chemistry   Vol. 3   page: 687-700   2005

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  108. Synthesis of Functionalized Cyclopentane for Pactamycin, A potent Antitumor Antibiotic Reviewed

    Tsujimoto, T.; Nishikawa, T.; Urabe, D.; Isobe, M.

    Synlett     page: 433-436   2005

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  109. A Novel and Highly Stereoselective Carbon-chain Extension Reaction at the C-6 Position of 1,6-Anhydropyranose Reviewed

    Nishikawa, T.; Mishima, M.; Ohyabu, N.; Isobe, M.

    Tetrahedron Letters   Vol. 45   page: 175-178   2004

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  110. Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analog of Puffer Fish Toxin Reviewed

    Nishikawa, T.; Urabe, D.; Yoshida, K.; Iwabuchi, T.; Asai, M.; Isobe, M

    Chemistry, A European Journal   Vol. 10   page: 452-462   2004

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  111. A novel deprotection of trichloroacetamide, Reviewed

    Urabe, D.; Sugino K.; Nishikawa, T.; Isobe, M.

    Tetrahedron Letters   Vol. 45   page: 9405-9407   2004

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  112. Novel Synthesis of Bromoindolenine with Spiro-b-lactam in Chartelline. Reviewed

    Nishikawa, T.; Kajii, S.; Isobe, M.

    Synlett     page: 2025-2027   2004

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  113. *An efficient total synthesis of optically active tetrodotoxin. Reviewed

    Nishikawa, T.; Urabe, D.; Isobe,

    Angewante. Chemie International Edition   Vol. 43   page: 4782-4785   2004

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  114. Synthesis of Model Compound Containing an Indole Spiro-b-lactam Moiety with Vinylchloride in Chartellines Reviewed

    Nishikawa, T.; Kajii, S.; Isobe, M.

    Chemistry Letters   Vol. 33   page: 440-441   2004

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  115. a-C-Mannnosyltryptophan is not recognized by conventional mannose-binding lectins Reviewed

    Nishikawa, T.; Kajii, S.; Sato, C.; Yasukawa, Z.; Kitajima, K.; Isobe, M.

    Bioorganic Medicinal Chemistry   Vol. 12   page: 2343-2348   2004

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  116. Biological activity of 8,11-dideoxytetrodotoxin: Lethality to mice and the inhibitory activity to cytotoxicity of ouabain and veratridine in mouse neuroblastoma cells, Neuro-2a Reviewed

    Yotsu-Yamashita, M.; Urabe, D.; Asai, M.; Nishikawa, T.; Isobe M.

    Toxicon   Vol. 42   page: 557-560   2003

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  117. "Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analog of Puffer Fish Toxin"

    Nishikawa, T.; Urabe, D.; Yoshida, K.; Iwabuchi, T.; Asai, M.; Isobe, M.

    Organic Letters   Vol. 4   page: 2679-2682   2002.7

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  118. Synthesis of Novel α-C-Glycosylamino Acids and Reverse Regioselectivity in Larock's Heteroannulation for the Synthesis of the Indole Nucleus

    Nishikawa, T.; Wada, K.; Isobe, M.

    Bioscience, Biotechnology & Biochemistry"   Vol. 66   page: 2273-2278   2002.1

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  119. Scandium Perchlorate as a Superior Lewis Acid for Regioselective Ring Opening of Aziridine Carboxylate with Indoles

    Nishikawa, T.; Kajii, S.; Wada, K.; Ishikawa, M.; Isobe, M.

    Synthesis   Vol. 1658-1662   2002.1

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  120. Total Synthesis of a-C-Mannosyltryptophan.

    Nishikawa, T.; Ishikawa, M.; Wada, K.; Isobe, M.

    Synlett     page: 945-947   2001.7

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  121. "Stereocontrolled Synthesis of (-)-5,11-Dideoxytetrodotoxin."

    "M. Asai, T. Nishikawa, N. Ohyabu, N. Yamamoto, M. Isobe"

    Tetrahedron   Vol. 57   page: 4543-4558   2001.4

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  122. Synthesis of Common Key Intermediate for (-)-Tetrodotoxin and its Analogs

    "Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Fukuda, Y.; Isobe, M."

    Tetrahdron   Vol. 57   page: 3875-3883   2001.4

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  123. Stereoselektive Synthese von (-)-5.11-didesoxytetrodotoxin.

    "Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Isobe, M."

    Angewandte Chemie   Vol. 111   page: 3268-3271   1999.11

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  124. Hydrosilylation of acetylenes with catalytic biscobalthexacarbonyl complex and its application to heteroconjugate addition methodology.

    "Isobe, M.; Nishizawa, R.; Nishikawa, T.; Yoza, K."

    Tetrahedron Letters   Vol. 40   page: 6927-6930   1999.5

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  125. Electronic Factors in the C-Glycosidation with Silylacetylene. Reviewed

    "29. Isobe, M.; Saeeng, R.; Nishizawa, R.; Konobe, M.; Nishikawa, T."

    Chemistry Letters     page: 467-468   1999.3

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  126. Palladium Catalyzed Substitution Reaction of Allylic Derivatives with Tinacetylene

    "Nishikawa T.; Isobe, M."

    "Bioscience, Biotechnology & Biochemistry"   Vol. 63   page: 238-242   1999.1

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  127. Synthesis of α-C-Mannosyltryptophan Derivative, Naturally Occurring C-Glycosyl Amino Acid Found in Human Ribonuclease." Reviewed

    "Nishikawa, T.; Ishikawa, M.; Isobe, M."

    Synlett     page: 123-125   1999.1

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  128. New Synthetic Route for Guanidine from Trichloroacetamide for Tetrodotoxin and its Related Compounds.

    "Nishikawa, T.; Ohyabu, N.; Yamamoto, N. ; Isobe, M."

    Tetrahedron   Vol. 55   page: 4325-4340   1999.1

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  129. Stereocontrolled Synthesis and Reactivity of Sugar Acetylene.

    "6. Isobe, M.; Nishizawa, R.; Hosokawa, S.; Nishikawa, T."

    "Journal of Chemical Society, Chemical Communications"     page: 2665-2676   1998.1

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  130. Stereoelectronic a Steric Effects for Critical Oxidation to the Cyclohexane Derivatives for an Intermediate to (-)-Tetrodotoxin. Reviewed

    "Bamba, M., Nishikawa, T. and Isobe, M.,"

    Synlett     page: 371-372   1998.1

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  131. Improved Coitions for Facile Overman Rearrangement.

    "Nishikawa, T., Asai, M., Ohyabu, N. and Isobe, M.,"

    Journal of Organic Chemistry   Vol. 63   page: 188-192   1998.1

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  132. Novel Stereoselective Reaction of Levoglucosenone with Furfural.

    "Nishikawa, T., Araki, H. and Isobe, M.,"

    "Bioscience, Biotechnology & Biochemistry"   Vol. 62 (#1)   page: 190-192   1998.1

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  133. Stereoelectronic a Steric Control in Chiral Cyclohexane Synthesis toward (-)-Tetrodotoxin.

    "Bamba, M., Nishikawa, T. and Isobe, M.,"

    Tetrahedron   Vol. 54   page: 6639-6650   1998.1

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  134. Stereoelectronic and Steric Control in Chiral Cyclohexane Synthesistoward (-)-Tetrodotoxin(共著)

    Bamba, M.; Nishikawa, T.; Isobe, M.

    Tetrahedron   Vol. 54 ( 24 ) page: 6639-6650   1998

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  135. Stereocontrolled Synthesis and Reactivity of Sugar Acetylene Reviewed

    Isobe, M.; Nishizawa, R.; Hosokawa, S.; Nishikawa, T.

    Journal of Chemical Society,Chemical Communications     page: 2665-2676   1998

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  136. Synthesis a Biological Evaluation of Novel Cyclic Enediyne Compous Related to Dynemicin A as Antitumor Agents. Reviewed

    "Unno, R., Michishita, H., Inagaki, H., Baba, Y., Jomori, T., Nishikawa, T. and Isobe, M.,"

    Chemical & Pharmaceutical Bulletin   Vol. 45   page: 125-133   1997.1

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  137. Structure-Activity Relationships of Cyclic Enediynes Related to Dynemicin A. Part 2: Synthesis a Antitumor Activity of 9- a 12-Substituted Enediynes. Reviewed

    "Unno, R., Michishita, H., Inagaki, H., Suzuki, Y., Baba, Y., Jomori, T., Moku, M., Nishikawa, T. and Isobe, M.,"

    Bioorganic & Medicinal Chemistry   Vol. 5   page: 903-919   1997.1

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  138. Structure-Activity Relationships of Cyclic Enediynes Related to Dynemicin A. Part 1: Synthesis a Antitumor Activity of 9-Acetoxy Enediyne Equipped with Aryl Carbamate Moieties. Reviewed

    "Unno, R., Michishita, H., Inagaki, H., Suzuki, Y., Baba, Y., Jomori, T., Nishikawa, T. and Isobe, M.,"

    Bioorganic & Medicinal Chemistry   Vol. 5   page: 883-901   1997.1

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  139. Synthesis a Antitumor Effects of Water-Soluble Enediyne Compous Related to Dynemicin A.

    "Unno, R., Michishita, H., Inagaki, H., Suzuki, Y., Baba, Y., Jomori, T., Nishikawa, T. and Isobe, M,"

    Bioorganic & Medicinal Chemistry   Vol. 5   page: 987-999   1997.1

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  140. "Enzyme inhibitors, synthesis and approach to mechanism." Invited Reviewed

    "Isobe, M., Tsuboi, K., Hosokawa, S., Bamba, M., Kira, K., Shibuya, S., Ohtani, I.I., Nishikawa, T. and Ichikawa, Y."

    Pure & Applied Chemistry   Vol. 69   page: 401-406   1997

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  141. "Tin-Assisted Cyclization for Chiral Cyclohexane Synthesis, An Alternative Route to (-)-Tetrodotoxin Skeleton."

    "Bamba, M., Nishikawa, T. and Isobe, M.,"

    Tetrahedron Letters   Vol. 37 (#45)   page: 8199-8202   1996.1

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  142. Synthesis of Anthraquinone Part of Dynemicin A via Diels-Alder Reaction.

    "Nishikawa, T., Moku, M., Suzuki, Y. and Isobe, M.,"

    Chemistry Letters   Vol. (#2)   page: 113-114   1996.1

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  143. Synthesis a Biological Evaluation of Both Enantiomers of Dynemicin A Model Compou.

    "Nishikawa, T., Yoshikai, M., Obi, K., Kawai, T., Unno, R., Jomori, T. and Isobe, M.,"

    Tetrahedron   Vol. 51   page: 9339-9352   1995.1

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  144. Synthesis and Biological Evaluation of Both Enantiomers of Dynemicin A Model Compound Reviewed

    Tetrahedron   Vol. 51   page: 9339   1995

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  145. Synthesis of Bicyclic Hydroxy Lactone Intermediate toward (-)-Tetrodotoxin.

    Yamamoto, N., Nishikawa, T. and Isobe, M.

    Synlett     page: 505-506   1995

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  146. Synthetic Studies on Antibiotic Dynemicin A. Synthesis of Cyclic Enediyne Model Compound of Dynemicin A Reviewed

    Nishikawa, T.; Ino, A.; Isobe, M.

    Tetrahedron   Vol. 50   page: 1449-1468   1994

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  147. Cesium Fluoride Promoted Cyclization in the Synthesis of Enediyne Antibiotics Reviewed

    Nishikawa, T.; Shibuya S.; Isobe, M.

    Synlett     page: 482-484   1994

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  148. One Pot Synthesis of Haloacetylenes from Trimethylsilylacetylene Reviewed

    Nishikawa, T.; Shibuya S.; Hosokawa, S.; Isobe, M.

    Synlett     page: 485-486   1994

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  149. Synthesis of Both Enantiomers of Dynemicin A Model Compound. New Remote Asymmetric Induction in Acetylide Addition into Quinoline Nucleus as Key Step.

    Nishikawa, T.; Yoshikai, M.; Obi, K.; Isobe, M.

    Tetrahedron Letters   Vol. 35   page: 7997-8000   1994

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  150. Synthetic Studies on Dynemicin A. New Quinoline Synthesis for C, D and E rings.

    Nishikawa, T.; Isobe, M.

    Tetrahedron   Vol. 50   page: 5621-5632   1994

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  151. Methodologies for Synthesis of Heterocyclic Compounds. Invited Reviewed

    Isobe, M.; Nishikawa, T.; Yamamoto, N.; Tsukiyama, T.; Ino, A.; Okita, T.

    Journal of Heterocyclic Chemistry,   Vol. 29   page: 619-625   1992

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  152. Silyl and Tin Acetylene as Nucleophile toward Acyliminium Cation, a Plausible Key Reaction for Dynemicin, Enediyne Antitumor Antibiotic Reviewed

    Nishikawa, T.; Isobe, M.; Goto, T.

    Synlett     page: 99-101   1991

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  153. Synthetic Studies on the Bicyclo[7,3,1]-tridecendiyne System in an Antitumor Antibiotic, Dynemicin A Reviewed

    Nishikawa, T.; Isobe, M.; Goto, T.

    Synlett     page: 393-394   1991

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  154. Synthesis of a Simple Model Compound of Dynemicin and Cycloaromatization with Pinacol-Pinacolone Rearrangement in the strained Enediyne Medium Ring Reviewed

    Nishikawa, T.; Ino, A.; Isobe; M.; Goto, T.

    Chemistry Letters     page: 1271-1274   1991

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  155. Synthetic Studies on (-)-Tetrodotoxin(3)-Nitrogenation through Overman Rearrangement and Guanidine Ring Formation Reviewed

    Tetrahedron Letters   Vol. 31   page: 3327-3330   1990

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  156. Asymmetric Synthesis via Heteroconjugate Addition-Valinol Template as Oxazolidine Heteroolefine vs Acetylenic Nucleophiles Reviewed

    Isobe, M.; Hirose, Y.; Shimokawa, K.; Nishikawa, T.; Goto, T.

    Tetrahedron Letters   Vol. 31   page: 5499-5502   1990

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  157. Methodology for Stereochemical Control in Bioactive Natural Product Synthesis --- New Methods toward Enediyne Antitumor Antibiotics. Invited Reviewed

    Isobe, M.; Nishikawa, T.; Herunsalee, A.; Tsukiyama, T.; Hirose, Y.; Shimokawa, K.; Goto, T.

    Pure & Applied Chemistry   Vol. 62   page: 2007-2012   1990

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  158. Synthesis of Chiral Cyclohexanes from Levoglucosenone and its Application to an Indole Alkaloid Reserpine Reviewed

    Isobe, M.; Fukami, N.; Nishikawa, T.; Goto, T.

    Heterocyles   Vol. 25   page: 521-532   1987

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  159. Synthetic Studies on a Stereochemically Complex Natural Product : Designs for the Total Synthesis of (-)-Tetrodotoxin Invited Reviewed

    Isobe, M.; Nishikawa, T.; Fukami, N.; Goto, T.

    Pure & Applied Chemistry   Vol. 59   page: 399-406   1987

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  160. Synthetic Studies on Tetrodotoxin [1] --- Stereocontrolled Synthesis of the Cyclohexane Moiety Reviewed

    Isobe, M.; Nishikawa, T.; Pikul, S.; Goto, T.

    Tetrahedron Letters   Vol. 28   page: 6485-6488   1987

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Books 19

  1. Antibiotics and Antiviral Compounds. Chemical Synthesis and Modification・Synthetic Studies toward Enediyne Antitumor Antibiotics.

    M. Isobe, T. Nishikawa( Role: Joint author)

    VCH  1993 

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    Language:English

  2. Levoglucosenone and Levoglucosans, Chemistry and Applications・Levoglucosenone as chiral pool for synthesis

    ( Role: Joint author)

    ATL Press.  1994 

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    Language:English

  3. Glycoscience, 2nd edition・C-Glycosylation, Chemical Glycosylation Reactions

    T. Nishikawa, M. Adachi, M. Isobe( Role: Joint author)

    Springer Verlag GmbH  2008 

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    Language:English

  4. 大丈夫、マタタビは安全です-ネコのマタタビ反応に依存性なし

    上野山怜子、西川俊夫、宮崎雅雄( Role: Joint author)

    科学通信  2024.2 

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    Total pages:6   Language:Japanese

  5. 無毒のフグ毒類縁体がフグを誘引する

    西川俊夫、安立昌篤、阿部秀樹( Role: Joint author)

    化学と生物  2024 

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    Total pages:3   Language:Japanese

  6. 「テトロドトキシンとフグ毒の謎」化学の要点シリーズ43海洋天然物化学日本化学会編

    西川俊夫、安立昌篤( Role: Joint author)

    共立出版  2024  ( ISBN:978-4-320-04484-5

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    Total pages:13   Language:Japanese Book type:Scholarly book

  7. ネコのマタタビ行動

    宮崎雅雄、上野山怜子、西川俊夫( Role: Joint author)

    科学通信  2023.5 

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    Total pages:6   Language:Japanese

  8. ネコがマタタビを舐め噛む特異な行動は防虫効果を高める

    上野山怜子、西川俊夫、宮崎雅雄( Role: Joint author)

    AROMA RESEARCH  2023 

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    Total pages:7   Language:Japanese Book type:Scholarly book

  9. フグは無毒のフグ毒の「匂い」を嗅ぐことができる

    阿部秀樹、鈴木偉久、安立昌篤、西川俊夫( Role: Joint author)

    AROMA RESEARCH  2023 

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    Total pages:7   Language:Japanese Book type:Scholarly book

  10. ネコにマタタビ-その特異な行動の謎

    上野山怜子、西川俊夫、宮崎雅雄( Role: Joint author)

    生物の科学 遺伝  2023 

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    Total pages:7   Language:Japanese Book type:Scholarly book

  11. フグ毒テトロドトキシンの全合成-多官能性天然物の合成は想定を超えた発見に満ちている。ドラマチック有機合成化学 感動の瞬間100, 有機合成化学協会雨編

    西川俊夫( Role: Joint author)

    化学同人  2023  ( ISBN:978-4-7598-2336-3

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    Total pages:2   Language:Japanese Book type:Scholarly book

  12. “科学”からの招待状「ネコにマタタビ反応の謎」

    安池智一、宮崎雅雄、西川俊夫、上野山怜子( Role: Joint author)

    放送大学  2022.8 

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    Language:Japanese Book type:Film/Video

  13. ネコ特有なマタタビ反応の知られざる機能-伝染病を媒介する蚊への化学的防御-

    上野山怜子、西川俊夫、宮崎雅雄( Role: Joint author)

    におい・かおり環境学会誌  2022 

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    Total pages:9   Language:Japanese Book type:Scholarly book

  14. 追悼 上村大輔教授

    西川俊夫( Role: Sole author)

    現代化学  2021.9 

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    Total pages:1   Language:Japanese Book type:Scholarly book

  15. 古くて新しい天然物化学の課題 ネコのマタタビ反応の謎を解く

    西川俊夫、上野山怜子、宮崎雅雄( Role: Joint author)

    現代化学  2021.5 

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    Total pages:6   Language:Japanese Book type:Scholarly book

  16. 「カスケード型環化反応による環状グアニジン天然物の合成」天然有機化合物の全合成—独創的なものづくりの反応と戦略—

    西川俊夫 中崎敦夫( Role: Joint author)

    化学同人  2018 

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    Total pages:8   Language:Japanese Book type:Scholarly book

  17. 「フグ毒の科学」天然物の化学 —魅力と展望—(上村大輔編)

    西川俊夫( Role: Joint author)

    東京化学同人  2016 

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    Total pages:8   Language:Japanese Book type:Scholarly book

  18. 「キノコから見つかった天然物チャキシンの合成」天然物の化学II —自然からの贈り物—(上村大輔編)

    西川俊夫( Role: Joint author)

    東京化学同人  2016 

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    Language:Japanese Book type:Scholarly book

  19. 第2版有機合成ハンドブック・官能基の保護

    西川俊夫( Role: Sole author)

    丸善出版株式会社  2015 

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    Language:Japanese Book type:Scholarly book

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MISC 4

  1. ネコがマタタビに反応する生物学的意義の解明 マタタビ への顔の擦り付けは蚊への化学防除を可能にする

    上野山怜子、西川俊夫、宮崎雅雄

    化学と生物   Vol. 59 ( 9 ) page: 435 - 440   2021

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    Language:Japanese  

  2. ネコのマタタビに対する特異的な反応は蚊に対する化学防御効果を有する

    上野山怜子、西川俊夫、宮崎雅雄

    AROMA RESEARCH   Vol. 22 ( 2 ) page: 30 - 36   2021

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    Language:Japanese  

  3. 数百年の疑問、ついに解決!「ネコにマタタビ」解明への道

    西川俊夫

        2020.2

  4. 生物活性天然物の効率的合成のための新合成方法論の開発 ―Chaxine類の生合成類似合成―

    西川俊夫

    有機合成化学協会誌   Vol. 78   page: 566 - 574   2020

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese  

Presentations 164

  1. イリドイド配糖体の合成研究

    西川俊夫、大岡左枝、上野山怜子、白武勝裕、宮崎雅雄

    日本農芸化学会2024年度大会  2024.3.24  日本農芸化学会

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  2. Collective synthesis of natural products for elucidation of their new biological activities Invited

    2024.3.18 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  3. 天然物の網羅的合成と新しい生物活性の探索 Invited

    西川俊夫

    富山県立大学工学部講演会  富山県立大学

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    Event date: 2023.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:富山県   Country:Japan  

  4. Collective Synthesis of Natural Products for Elucidation of New Biological Activities Invited International conference

    Toshio Nishikawa

    Symposium Nagoya University-University of Strasbourg“Frontiers: a multiple landscape”  2023.10.12  Strasbourg University

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    Event date: 2023.10

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Strasbourg, France   Country:France  

  5. Collective Synthesis of Natural Products for Elucidation of New Biological Activities Invited International conference

    Toshio Nishikawa

    有機合成化学協会創立80周年記念国際シンポジウム  2023.7.20  有機合成化学協会

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    Event date: 2023.7

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京   Country:Japan  

  6. 有機合成化学を駆使したエンジイン抗生物質の生合成機構解明への挑戦

    西川俊夫

    学術変革領域研究(A)予知生合成科学 第2回公開シンポジウム  2023.6.10 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  7. 天然物の網羅的合成と新しい生物活性の探索 Invited

    西川俊夫

    東北大学理学研究科講演会  2023.5.22  東北大学

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    Event date: 2023.5

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:仙台   Country:Japan  

  8. Picrotoxininの不斉全合成

    松村泰志、西川俊夫、中崎敦夫

    日本農芸化学会2023年度大会  2023.3.14 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:日本農芸化学会2023年度大会   Country:Japan  

  9. マタタビのネコに対する嗅覚エンリッチメントとしての安全で効果的な活用

    上野山怜子、大岡左枝、宮崎珠子、西川俊夫、宮崎雅雄

    日本農芸化学会2023年度大会  2023.3.14  日本農芸化学会2023年度大会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島・オンライン  

  10. アプリシアトキシンの骨格修飾によるPKC活性化剤の探索研究

    森下真菜、波田航平、新木悠介、入江一浩、西川俊夫

    日本農芸化学会2023年度大会  2023.3.14  日本農芸化学会2023年度大会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島・オンライン   Country:Japan  

  11. ホタルルシフェリンの実用的なone-pot合成法の開発研究

    加藤まりあ、土橋一耀、西川俊夫

    日本農芸化学会2023年度大会  2023.3.14  日本農芸化学会2023年度大会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島・オンライン   Country:Japan  

  12. ネペタラクトール関連化合物の配糖体の合成研究

    大岡左枝、西川俊夫

    日本農芸化学会2023年度大会  2023.3.14  日本農芸化学会2023年度大会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島・オンライン   Country:Japan  

  13. 推定生合成機構に基づくインドールテルペンアルカロイドの合成研究

    竹本亜矢、内山真伸、西川俊夫

    日本農芸化学会2023年度大会  2023.3.14  日本農芸化学会2023年度大会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島・オンライン   Country:Japan  

  14. 9員環エンジイン抗生物質の新規骨格構築法の開発

    浅野耕太、西川俊夫

    日本農芸化学会 2023年度大会  2023.3.14  日本農芸化学会 2023年度大会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島・オンライン   Country:Japan  

  15. アプリシアトキシン・オシラトキシン類縁体の網羅的合成法の開発

    波田航平、新木悠介、野倉吉彦、西川俊夫

    日本農芸化学会2023年度大会  2023.3.14  日本農芸化学会2023年度大会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島・オンライン   Country:Japan  

  16. leafy gall形成を引き起こす植物病原菌が合成するサイトカイニン様化合物の構造と生合成経路の解明

    宮田和輝、吉野実花、Alicia Surjana、小嶋美紀子、幸木謙典、西川俊、榊原均

    第64回日本植物生理学会年会  2023.3.10  第64回日本植物生理学会年会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台・オンライン  

  17. ネコのマタタビ反応の研究から着想した蚊の忌避剤の開発 Invited

    西川俊夫

    2023年度産学官学術交流フォーラム  2023.3.1 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:広島   Country:Japan  

  18. Analysis of one-pot synthesis of firefly luciferin.

    加藤まりあ、西川俊夫

    GTR成果報告会  2023.1.16  GTR成果報告会

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    Event date: 2023.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  19. AplysiaenalとNhatrangin Aの不斉全合成と提唱立体構造の確定

    森下真菜、波田航平、西川俊夫

    第53回中部化学関係学協会支部連合大会  2022.11.5  第53回中部化学関係学協会支部連合大会

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知・オンライン   Country:Japan  

  20. ネペタラクトールの配糖体の合成

    大岡左枝、西川俊夫

    公益社団法人日本農芸化学会中部支部第193回例会  2022.10.1  公益社団法人日本農芸化学会中部支部第193回例会

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋・オンライン   Country:Japan  

  21. 分子間Mizoroki-Heck反応を鍵とするpicrotoxininの合成研究

    松村泰志、西川俊夫、中崎敦夫

    第38回有機合成化学セミナー  2022.9.28  第38回有機合成化学セミナー

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  22. アプリシアトキシン・オシラトキシン類縁体の網羅的合成法の開発

    波田航平、新木悠介、野倉吉彦、占部大介、西川俊夫

    第64回天然有機化合物討論会  2022.9.7  第64回天然有機化合物討論会

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:静岡   Country:Japan  

  23. ヒラムシ含有アナログの種間差に関する研究

    田中真誠、尾山輝、小島雄基、由井健太郎、杉田治男、榊原良、中東亮太、西川俊夫、安立昌篤、周防玲、糸井史郎

    令和4年度日本水産学会秋季大会  2022.9.5  日本水産学会

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎   Country:Japan  

  24. 天然物リガンドを利用した生体膜経由の化学シグナル伝達機構の解明 Invited

    西川俊夫

    新学術領域研究「化学コミュニケーションのフロンティア」取りまとめシンポジウム  2022.7.9  新学術領域研究「化学コミュニケーションのフロンティア」

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:京都   Country:Japan  

  25. オオツノヒラムシの性成熟に伴うTTXの局在変化 Invited

    尾山輝、伊藤正晟、周防玲、杉田治男、安⽴昌篤、⻄川俊夫、モリテツシ、糸井史朗

    第22回マリンバイオテクノロジー学会  2022.5.28  第22回マリンバイオテクノロジー学会

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    Event date: 2022.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  26. オオツノヒラムシにおけるテトロドトキシンの生産と細菌の寄与

    米澤遼、林健太朗、吉武和敏、JDM Senevirathna、スミス梨花、満山進、木下滋晴、尾山輝、上田紘之、周防玲、杉田治男、安立昌篤、西川俊夫、モリテツシ、糸井史朗、浅川修一

    令和4年日本水産学会春季大会 

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    Event date: 2022.3

    Presentation type:Oral presentation (general)  

    Venue:オンライン  

  27. 古くて新しい天然物化学の課題:ネコのマタタビ 反応の謎に挑戦する Invited

    西川俊夫

    中長期テーマシンポジウム 「生物現象鍵物質の研究展開」 日本化学会第102春季年会(2022)  2022.3.23 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:オンライン  

  28. 空気酸化によるergosterolの構造多様化機構の解析

    宮田和輝、Alicia Surjana、小嶋美紀子、幸木謙典、西川俊夫、榊原均

    第63回日本植物生理学会年会 

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    Event date: 2022.3

    Presentation type:Oral presentation (general)  

    Venue:茨城・オンライン  

  29. 植物病原Rhodococcus fascians が作り出す新奇サイトカイニンの構造と機能の解明

    吉野実花、Alicia Surjana、 小嶋美紀子、 幸木謙典、 西川俊夫、 榊原均

    第63回日本植物生理学会年会 

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    Event date: 2022.3

    Presentation type:Oral presentation (general)  

    Venue:茨城・オンライン  

  30. テトロドトキシン推定生合成中間体4,9-アンヒドロ-10-ヘミケタール-5-デオキシテトロドトキシンの8-デオキシアナログの合成

    宮坂忠親、安立昌篤、西川俊夫

    日本農芸化学会2022年度大会 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:京都・オンライン  

  31. ピクロトキシニンの合成研究

    松村泰志、西川俊夫、中崎敦夫

    日本農芸化学会2022年度大会 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:京都・オンライン  

  32. 生合成を模倣したノル-3,4-セコトリテルペノイドのA環部分の構築

    多湖光佑、西川俊夫、中崎敦夫

    日本農芸化学会2022年度大会 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:京都・オンライン  

  33. テトロドトキシンの推定生合成中間体Tb-210B、Tb-226、Tb-242C、Tb-258の全合成

    西海眞史、安立昌篤、西川俊夫

    日本農芸化学会2022年度大会 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:京都・オンライン  

  34. アプリシアトキシン・オシラトキシン類縁体の網羅的合成法の開発

    波田航平、新木悠介、野倉吉彦、花木祐輔、中崎敦夫、西川俊夫

    日本農芸化学会2022年度大会 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:京都・オンライン  

  35. 9員環エンジイン構造の新規合成法の開発

    浅野耕太、二木美咲、西川俊夫

    日本農芸化学会2022年度大会 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:京都・オンライン  

  36. ネコがマタタビやキャットニップの葉を舐め噛む行動は蚊への化学防御効果の促進に寄与する

    (1上野山怜子、宮崎珠子、Hurst Jane. L.、安立昌篤、西川俊夫、宮崎雅雄

    日本農芸化学会2022年度大会 

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    Event date: 2022.3

    Language:English  

    Venue:京都・オンライン  

  37. Unifiefd synthesis of aplysiatoxin/ocillatoxins, Hawaiian marine natural products. New Frontier of chemical probes exploring biology and medicine. Invited International conference

    Toshio Nishikawa

    The international chemical congress of PACIFIC BASIN SOCIETIES 2021  2021.12.19 

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    Event date: 2021.12

    Language:English   Presentation type:Oral presentation (invited, special)  

  38. アプリシアトキシン・オシラトキシン類縁体の網羅的合成法の開発

    波田航平、新木悠介、花木祐輔、野倉吉彦、西川俊夫

    第119回有機合成シンポジウム 

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    Event date: 2021.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:東京・オンライン  

  39. 4,9-アンヒドロ-10-ヘミケタール-5-デオキシテトロドトキシンの合成研究

    宮坂忠親、安立昌篤、西川俊夫

    第52回 中部化学関係学協会支部連合秋季大会 

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    Event date: 2021.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:静岡・オンライン  

  40. テトロドトキシンの推定生合成中間体Tb-242Cの全合成

    西海眞史、安立昌篤、西川俊夫

    第50回複素環化学討論会 

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    Event date: 2021.10

    Language:English  

    Venue:静岡・オンライン  

  41. マタタビ反応中のネコが葉を舐め噛む行動は葉から防蚊活性物質の放出を促進する

    上野山怜子、宮崎珠子、安立正篤、西川俊夫、宮崎雅雄

    2021年度日本味と匂学会第55回大会 

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    Event date: 2021.9

    Presentation type:Oral presentation (general)  

    Venue:福岡  

  42. 生物機能の解明を目指した天然有機化合物の網羅的合成 Invited

    西川俊夫

    第37回有機合成化学セミナー 

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    Event date: 2021.9

    Language:Japanese  

    Venue:オンライン  

  43. 強心ステロイド類の自在合成法の開発と(+)-Cannogenol の全合成

    渡邉正悟、西川俊夫、中崎敦夫

    第63回天然有機化合物討論会 

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    Event date: 2021.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:大阪・オンライン  

  44. ステロイド系天然物フィサリン類の合成研究-CDE環の生合成類似合成-

    新木悠介、中崎敦夫、西川俊夫

    第63回天然有機化合物討論会 

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    Event date: 2021.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:大阪・オンライン  

  45. フグ毒保有生物オオツノヒラムシの産卵生態に及ぼす水温の影響

    尾山輝、岡部泰基、周防玲、杉田治男、安立昌篤、西川俊夫、糸井史郎

    令和3年度日本水産学会秋季大会 

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    Event date: 2021.9

    Language:Japanese  

    Venue:北海道  

  46. Toward collective synthesis of Hawaiian marine natural products. Invited International conference

    Toshio Nishikawa

    Interactive Seminar  2021.8.28 

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    Event date: 2021.8

    Language:English   Presentation type:Oral presentation (invited, special)  

  47. 有機合成を駆使して生命科学の課題解明に挑戦する-天然物サイエンスの勧め- Invited

    西川俊夫

    GTRシリーズ講義2021  2021.5.27 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン  

  48. 琉球列島におけるフグ毒保有魚の稚魚期の毒性に関する研究

    伊藤正晟、古川理紗子、尾山輝、佐藤雅哉、周防玲、杉田治男、中東亮太、榊原良、安⽴昌篤、⻄川俊夫、高谷智裕、荒川修、糸井史朗

    第21回マリンバイオテクノロジー学会 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京・オンライン  

  49. ステロイド系天然物Physalin類の合成研究

    新木悠介、中崎敦夫、西川俊夫

    日本農芸化学会2021年度大会  2021.3 

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    Event date: 2021.3

    Venue:仙台・オンライン  

  50. 高等菌類の子実体形成促進物質 chaxine Bの生合成研究

    難波良太、岸本真治、呉静、西川俊夫、守屋央朗、及川英秋、河岸洋和、渡辺賢二

    日本農芸化学会2021年度大会  2021.3 

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    Event date: 2021.3

    Venue:仙台・オンライン   Country:Japan  

  51. ネコのマタタビへの擦り付け行動は蚊の化学防除を可能にする

    上野山怜子、宮崎珠子、Jane L.Hurst、Robert J.Beynon、安立昌篤、小野田伊吹、西川俊夫 、立花大、箕浦広大、長尾耕治郎、木村泰久、植田和光、宮崎雅雄

    日本農芸化学会2021年度大会  2021.3 

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    Event date: 2021.3

    Venue:仙台・オンライン   Country:Japan  

  52. アプリシアトキシン及びオシラトキシン類縁体の合成

    波田航平、西川俊夫、中崎敦夫

    日本農芸化学会2021年度大会  2021.3 

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    Event date: 2021.3

    Venue:仙台・オンライン   Country:Japan  

  53. クランベシンBメチルエステルの合成研究

    丹台剛太朗、西川俊夫、中崎敦夫

    日本農芸化学会2021年度大会  2021.3 

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    Event date: 2021.3

    Venue:仙台・オンライン   Country:Japan  

  54. テトロドトキシンの推定生合成中間体Tb-242Cの合成研究

    西海眞史、西川俊夫、安立昌篤

    日本農芸化学会2021年度大会  2021.3 

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    Event date: 2021.3

    Venue:仙台・オンライン   Country:Japan  

  55. ノルトリテルペノイドの A 環部分の構築

    多湖光佑、西川俊夫、中崎敦夫

    日本農芸化学会2021年度大会  2021.3 

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    Event date: 2021.3

    Venue:仙台・オンライン   Country:Japan  

  56. 19-nordigitoxigeninの全合成

    松村泰志、西川俊夫、中崎敦夫

    日本農芸化学会2021年度大会  2021.3 

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    Event date: 2021.3

    Venue:仙台・オンライン   Country:Japan  

  57. (+)-cannogenolの全合成

    渡邉正悟、西川俊夫、中崎敦夫

    日本農芸化学会2021年度大会  2021.3 

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    Event date: 2021.3

    Venue:オンライン   Country:Japan  

  58. 4,9-アンヒドロ-10-ヘミケタール-5-デオキシテトロドトキシンの合成研究

    宮坂忠親、安立昌篤、西川俊夫

    日本農芸化学会2021年度大会  2021.3 

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    Event date: 2021.3

    Venue:仙台・オンライン   Country:Japan  

  59. 有機合成で生命農学・生命科学の課題解明に挑戦する

    西川俊夫

    第5回名大・岐大農学シンポジウム〜TOKAIからSEKAIへ〜  2020.12.22 

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    Event date: 2020.12

    Venue:オンライン   Country:Japan  

  60. 外来生物の誘引現象の理解と駆除を目指した強心ステロイドの非天然型アナログの創出: cannogenolの全合成

    中崎敦夫、渡邉正悟、西川俊夫

    新学術領域研究「化学コミュニケーションのフロンティア」第2回領域リトリート  2020.12.16 

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    Event date: 2020.12

    Venue:オンライン   Country:Japan  

  61. ネコのマタタビ反応は蚊の忌避を可能にする

    上野山怜子、宮崎珠子、足立昌篤、小野田伊吹、山下哲郎、西川俊夫、宮崎雅雄

    公益社団法人日本農芸化学会東北支部第155回大会  2020.11 

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    Event date: 2020.11

    Venue:オンライン   Country:Japan  

  62. ネコのマタタビ反応2:擦り付け行動は蚊の化学防除を可能にする

    上野山怜子、西川俊夫、宮崎雅雄

    第39回日本動物行動学会大会  2020.11 

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    Event date: 2020.11

    Venue:オンライン   Country:Japan  

  63. 19-ノル型強心ステロイドの合成研究

    松村泰志、西川俊夫、中崎敦夫

    第117回有機合成シンポジウム  2020.10.29 

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    Event date: 2020.10

    Venue:オンライン   Country:Japan  

  64. Aplysiatoxin/oscillatoxin類の網羅的合成研究

    西川俊夫

    反応集積化が導く中分子戦略:高次生物機能分子の創製 令和2年度取りまとめシンポジウム  2020.10.22 

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    Event date: 2020.10

    Venue:オンライン  

  65. 構造決定を目的としたウミヤツメのフェロモン様物質petromyzestrosterolの合成研究

    河合真穂、西川俊夫、中崎敦夫

    日本農芸化学会中部支部第187回例会  2020.9.26 

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    Event date: 2020.9

    Venue:名古屋   Country:Japan  

  66. チャキシンBおよび類縁化合物の生合成類似合成

    平田裕嗣、二木美咲、中崎敦夫、呉静、河岸洋和、西川俊夫

    第62回天然有機化合物討論会  2020.9.24 

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    Event date: 2020.9

  67. 高等菌類におけるホルモンの探索

    呉静、佐藤俊太郎、桑原重文、二木美咲、平田裕嗣、中崎敦夫、西川俊夫、菅敏幸、崔宰熏、平井浩文、河岸洋和

    第62回天然有機化合物討論会  2020.9.22 

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    Event date: 2020.9

    Venue:名古屋・オンライン   Country:Japan  

  68. ネコ科動物特異な反応を誘起する新たなイリドイドの同定はマタタビ反応の行動意義を解明した。

    上野山怜子、宮崎珠子、足立昌篤、室岡孝信、小野田伊吹、片山理恵子、宮澤悠、山下哲郎、西川俊夫、宮崎雅雄

    第62回天然有機化合物討論会  2020.9.22 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋・オンライン   Country:Japan  

  69. ネコ科動物にマタタビ反応を誘起するイリドイド化合物の同定

    上野山怜子、室岡孝信、足立昌篤、小野田伊吹、山下哲郎、西川俊夫、宮崎雅雄

    第93回日本生化学会大会  2020.9 

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    Event date: 2020.9

    Venue:オンライン   Country:Japan  

  70. 網羅合成を目指した連続反応による天然物合成 Invited

    西川俊夫

    有機合成2月セミナー“有機合成のニュートレンド2018” 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  71. カスケード型環化反応によるグアニジン系天然物の合成 Invited

    西川俊夫

    東北大学天然物生命化学セミナー 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  72. Concise Synthesis of Oscillatoxin D and its analogues. International conference

    Toshio Nishikawa

    The Second A3 Roundtable Meeting on Chemical Probe Research Hub 

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    Event date: 2017.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:China  

  73. 生物がつくる化学物質の不思議を解き明かす Invited

    西川俊夫

    東京清陵会「科学の最前線を語り合う」 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  74. カスケード反応による天然物合成 Invited

    西川俊夫

    公開講演会 最新化学談話シリーズ 九州大学大学院理学研究院 

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    Event date: 2017.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  75. Syntheses of Biologically Active Natural Products by Means of Cascade Reactions. International conference

    Toshio Nishikawa

    Seminar at CRI 

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    Event date: 2017.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  76. Synthesis of Natural Products in Bioagricultural Sciences. International conference

    Toshio Nishikawa

    Joint Degree Conference on Science and Technology Cooperation relationship in Agriculture for Next Generation 

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    Event date: 2017.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  77. Synthesis of Natural Products in Bioagricultural Sciences. International conference

    Toshio Nishikawa

    Joint Degree Conference on Science and Technology Cooperation relationshio in Agriculture for Next generation 

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    Event date: 2017.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Thailand  

  78. 連続環化反応を使った天然物合成 Invited

    西川俊夫

    「静岡発のケミカルバイオロジー研究」静岡三大学連携講義(フロンティア科学特論II)B-nest 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  79. グアニジン系天然物の合成 Invited

    西川俊夫

    有機合成化学講習会−天然物合成ともの創りの新手法開発− 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  80. Synthesis of Biologically Active Natural Products by Means of Cascade Reactions. International conference

    Toshio Nishikawa

    ACP Lectureship Tour 

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    Event date: 2016.10 - 2016.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:China  

  81. Biomimetic Synthesis & Structure Determination of Biologically Active Steroidal Natural Products. International conference

    Toshio Nishikawa, Yushi Hirata, Atsuo Nakazaki

    The 1st A3 Roundtable Meeting on Chemical Probe Research Hub  

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  82. カスケード型反応による天然物合成

    西川俊夫

    東京工業大学大学院理工学専攻 講演会 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  83. Synthesis of biologically active steroid-derived compounds from an edible mushroom. International conference

    Toshio Nishikawa, Yoshiki Nakane, Atsuo Nakazaki, Takuya Imazu, Shouta Tokoro, Ryo Sakakibara, Masaatsu Adachi, Keiichi Konoki, Mari Yotsu-Yamashita

    The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015) 

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    Event date: 2015.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  84. Synthesis and biological activities of guanidine-containing natural products. International conference

    Toshio Nishikawa, Yoshiki Nakane, Atsuo Nakazaki, Takuya Imazu, Shouta Tokoro, Ryo Sakakibara, Masaatsu Adachi, Keiichi Konoki, Mari Yotsu-Yamashita

    The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015) 

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    Event date: 2015.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  85. Biomimetic Synthesis of Biologically Active Steroidal Natural Products. International conference

    Toshio Nishikawa

    ICCEOCA-10/ARNCEOCA-1 

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    Event date: 2015.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  86. Syntheses of Guanidine-containing Natural Products Aiming at development of Ion-channel Blockers. International conference

    Toshio Nishikawa

    10th AFMC International Medicinal Chemistry Symposium (AIMECS2015) 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Korea, Republic of  

  87. yntheses of Biologically Active natural products by Means of Cascade Reactions. International conference

    Toshio Nishikawa

    The 6th Japanese-Sino Symposium on Organic Chemistry for Young Scientists 

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    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  88. Biomimetic Synthesis of Biologically Active Steroidal Natural Products. International conference

    Toshio Nishikawa

    Kick-off Symposium on Advanced Research Network for Cutting-Edge Organic Chemistry in Asia 

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    Event date: 2015.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  89. 天然物合成と構造決定 Invited

    西川俊夫

    静岡大学講演会 

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    Event date: 2015.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  90. Synthesis of Guanidine-containing Natural Products by Means of Cascade Bromocylization. International conference

    Toshio Nishikawa

    International Symposium on Natural Products Chemistry and Chemical Biology 2014 

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    Event date: 2014.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:China  

  91. Syntheses and Bilogical Activities of Guanidine-containing Natural Products International conference

    Toshio Nishikawa, Atsuo Nakazaki, Yoshiki Nakane, Yuki Ishikawa, Masaatsu Adachi, Keiichi Konoki, Yukie Chiba, Tsukamoto D.; Yotsu-Yamashita

    The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity 

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    Event date: 2014.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  92. 含グアニジン天然物の全合成研究 Invited

    西川俊夫

    平成26年度日本農芸化学会関西支部 京都府立大学 生命分子化学科•鴨叡会セミナー 有機化学•天然物化学セミナー 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  93. ヘテロ環天然物の全合成研究—天然物合成は新反応発見の場(きっかけ)となるか?— Invited

    西川俊夫

    神戸大学有機化学講演会 

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    Event date: 2014.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  94. 含グアニジン天然物の全合成研究—新規イオンチャネル阻害剤の開発を目指して Invited

    西川俊夫

    第25回記念万有仙台シンポジウム 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  95. Syntheses of Guanidine-Containing Natural products by Means of Cascade Boromocyclization. International conference

    Toshio Nishikawa

    The International Startup Symposium of Cutting-Edge Organic Chemistry in Asia (III)  

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    Event date: 2014.4

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Taiwan, Province of China  

  96. グアニジン天然物の合成研究 Invited

    西川俊夫

    神戸薬科大学特別研究セミナー 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  97. 含グアニジン天然物の合成研究—イオンチャネル阻害剤の創製を目指して— Invited

    西川俊夫

    住友化学株式会社 健康・農業関連事業研究所講演会 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  98. Synthetic Studies on Tagetitoxin International conference

    Hitomi Yamada, Masaatsu Adachi, Toshio Nishikawa.

    The 8th International Conference on Cutting-Edge Organic Chemistry in Asia and The 4th New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-8/NICCEOCA-4)  

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    Event date: 2013.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  99. Total syntheses on guanidine-containing natural products. International conference

    Toshio Nisikawa

    ACP Lectureship Tour 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Korea, Republic of  

  100. Synthesis of guanidine-containing natural products International conference

    ACP Lectureship Tour 

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    Event date: 2013.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Singapore  

  101. ヘテロ環天然物の合成研究 Invited

    西川俊夫

    平成25年度有機合成化学協会東海支部 若手研究者のためのセミナー 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  102. テトロドトキシンの全合成研究 –フグ毒の謎を追って– Invited

    西川俊夫

    理研シンポジウム 未来に繋ぐ天然物合成化学 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  103. 多環多官能性天然物の合成戦略。日本薬学会シンポジウム「新しい分子構築戦略ー効率的な生物活性分子の合成に向けてー」 Invited

    西川俊夫

    日本薬学会第133年会 

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    Event date: 2013.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  104. Synthetic Studies on Nitrogen-Containing Natural Products International conference

    Toshio Nishikawa, Masaatsu Adachi, Ryo Sakakibara, Shouta Tokoro, Takuya Imazu, Yoshiki Satake, Minoru Isobe

    Pure and Applied Chemistry International Conference 2013 

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    Event date: 2013.1

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Thailand  

  105. Collective Synthesis of Tetrodotoxin and its Analogus International conference

    Toshio Nishikawa, Masaatsu Adachi, Ryo Sakakibara, Shouta Tokoro, Takuya Imazu, Yoshiki Satake, Minoru Isobe

    The 7th International Conference on Cutting-Edge Organic Chemistry in Asia and The 3rd New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-7/NICCEOCA-3)  

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    Event date: 2012.12

    Language:English   Presentation type:Poster presentation  

    Country:Singapore  

  106. Synthesis of Guanidine-Containing Natural Products. International conference

    Toshio Nishikawa

    International Symposium on Natural Products Chemistry and Chemical Biology 2012 

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    Event date: 2012.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:China  

  107. ヘテロ環天然物の全合成研究 ---天然物合成は新反応発見の場(きっかけ)となるか Invited

    西川俊夫

    筑波大学大学院物質化学研究科講演会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  108. Synthesis of Marine Toxins Aiming at Developing Ion-Channel Inhibitors International conference

    Toshio Nishikawa, Masaatsu Adachi, Ryo Sakakibara, Takuya Imazu, Yoshiki Satake, Minoru Isobe

    The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity 

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    Event date: 2012.10 - 2012.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  109. ヘテロ環天然物の全合成研究 ---天然物合成は新反応発見の場(きっかけ)となるか

    西川俊夫

    広島大学大学院理学研究科 特別講演会 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  110. Synthetic Studies on Guanidine-Containing Natural Products International conference

    Toshio Nishikawa

    ACP Lectureship Tour 

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    Event date: 2012.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Hong Kong  

  111. イオンチャネル阻害剤の創製を目指した海産天然毒の化学合成 Invited

    西川俊夫

    シンポジウム 4SY09「天然物ケミカルバイオロジー」日本農芸化学会2012年度大会 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  112. A New Synthetic Route to the Saxitoxin Skelton International conference

    Toshio Nishikawa, Yusuke Sawayama

    The 6th International Conference on Cutting-edge Organic Chemistry in Asia (ICCEOCA-6), The 2nd New Phase International Conference on Cutting-edge Organic Chemistry in Asia 

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    Event date: 2011.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Hong Kong  

  113. 含グアニジン天然物の合成研究―イオンチャネル阻害剤の創製を目指して― Invited

    西川俊夫

    第356回東北大学大学院薬学研究科セミナー 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  114. ヘテロ環天然物の全合成研究―天然物合成は新規反応発見の場(きっかけ)となるか? Invited

    西川俊夫

    関西学院大学理工学部講演会 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  115. テトロドトキシン類の化学合成とフグ毒の謎。『That's 応用生命科学』有機化学、分子生物学、食品科学の最新研究から見る応用生命科学のいま Invited

    西川俊夫

    日本農芸化学会中部支部第161回例会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  116. 含窒素生理活性天然物の合成イオンチャネルを阻害する天然毒素とその類縁体の化学合成― Invited

    西川俊夫

    新規素材探索研究会第10回セミナー 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  117. イオンチャネルを阻害する天然毒素とその類縁体の化学合成 Invited

    西川俊夫

    平成22年度長瀬科学 技術振興財団研究 成果報告会 

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    Event date: 2011.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  118. Synthetic Studies on Biologically Active Natural Products International conference

    Toshio Nishikawa, Kumi Sugino, Atsuo Nakazaki, Keiko Higuchi, Masaatsu Adachi, Nopporn Thasana, Minoru Isobe

    The 9th NRCT-JSPS Joint Seminar 2010 "Natural Medicine Research for the Next Decade: New Challenges and Furture Collaboration 

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    Event date: 2010.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Thailand  

  119. Multi-functionality of N-Trichloroacetyl Group Developed in the Synthesis of Tetrodotoxin and its Analogues International conference

    Toshio Nishikawa, Masaatsu Adachi, Ryo Sakakibara, Yoshiki Satake, Minoru Isobe

    The 5th International Conference on Cutting-edge Organic Chemistry in Asia (ICCEOCA-5), The 1st New phase International Conference on Cutting-edge Organic Chemistry in Asia 

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    Event date: 2010.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  120. Total Synthesis of Polygalolide A Invited International conference

    Masaatsu Adachi, Hitomi Yamada, Minoru Isobe, Toshio Nishikawa

    The Pre-Symposium of 5th International Conference on Organic Chemistry in Asia 

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    Event date: 2010.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Taiwan   Country:Taiwan, Province of China  

  121. テトロドトキシンの合成-古くて新しい天然物の合成- Invited

    西川俊夫

    20周年記念万有福岡シンポジウム 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  122. 天然物の全合成研究の楽しみ Invited

    西川俊夫

    上村大輔教授を祝う講演会 

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    Event date: 2010.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  123. A Novel Reverse Prenylation of Indol Derivatives by means of Acetylene Cobalt Complex. Invited International conference

    Toshio Nishikawa, Hisaaki Isaji, Atsuo Nakazaki, Minoru Isobe

    The 4th International Conference on Cutting-Edge Organic Chemistry in Asia 

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    Event date: 2009.11 - 2009.12

    Language:English   Presentation type:Poster presentation  

    Country:Thailand  

  124. ヘテロ環天然物の全合成研究----天然物合成は新反応発見の場となるか?--- Invited

    西川俊夫

    平成21年度有機合成協会東海支部 有機合成セミナー 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  125. Synthesis Studies on Naturally Occuring Heterocycles International conference

    The 8th NRCT-JSPS Joint Seminar: Innovative Research in Natural Products for Sustainable Development 

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    Event date: 2009.2

    Language:English   Presentation type:Oral presentation (invited, special)  

  126. 合成プローブを活用したテトロドトキシンの食物連鎖機構および生合成経路の解明 Invited

    西川俊夫

    第22回内藤コンファレンス 

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    Event date: 2009

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  127. フグ毒テトロドトキシンの合成研究から学んだ天然物合成の魅力

    西川俊夫

    理研シンポジウム「第9回 分析・解析技術と化学の最先端」 

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    Event date: 2008.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  128. 多官能基性天然物の合成研究ーフグ毒テトロドトキシンの更に効率よい合成法を求めてー

    西川俊夫

    第39回中部化学関係学協会支部連合秋季大会 特別討論会[有機合成化学](触媒反応と全合成) 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  129. Total Synthesis of 5-Deoxytetrodotoxin, A Prlausible Biosynthetic Precursor for Tetrodotoxin. International conference

    The 3rd International Conference on Cutting-Edge Organic Chemistry in Asia 

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    Event date: 2008.10

    Language:English   Presentation type:Poster presentation  

  130. Studies for Biosynthesis and Food Chain Mechanism of Tetrodotoxin by using its Synthetic probes

    The 22nd Naito Conference on Chemical Biology [I] 

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    Event date: 2008.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  131. 天然物合成と反応開発 ーフグ毒テトロドトキシンの全合成研究を例にとってー(依頼講演)

    西川俊夫

    第37回中部化学関係学協会支部連合秋季大会 

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    Event date: 2006.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  132. Synthetic Studies on Chartelline C, a Marine Alkaloid International conference

    1st International Conference on Cutting-Edge Organic Chemistry in Asia 

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    Event date: 2006.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  133. Multi-functionality of Trichloroacetamide in Tetrodotoxin Synthesis. International conference

    JSPS Asian Core Program 0th International Conference on Cutting Edge Organic Chemistry in Asia 

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    Event date: 2006.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  134. フグ毒テトロドトキシンの不斉全合成 – 古くて新しい合成標的 -(招待講演)

    日本薬学会北陸支部特別講演会 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  135. Synthesis of Tetrodotoxin and its Related Compounds

    The 2nd Yamada Symposium on Key Natural Organic Molecules in Biological Systems 

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    Event date: 2005.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  136. フグ毒テトロドトキシンの全合成 -- その道のり--(招待講演)

    第40回天然物化学談話会 

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    Event date: 2005.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  137. フグ毒テトロドトキシンの全合成研究(招待講演)

    平成17年度有機合成化学協会東海支部 若手研究者のためのセミナー 

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    Event date: 2005.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  138. 新規微量糖鎖C-マンノシルトリプトファンの生物有機化学的研究(招待講演)

    西川俊夫

    糖鎖科学名古屋拠点シンポジウム 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  139. Studies toward the Total Synthesis of Pactamycin. International conference

    15th International Conference on Organic Synthesis 

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    Event date: 2004.8

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  140. Asymmetric Total Synthesis of Tetrodotoxin. International conference

    Japan-Korea Young Scientist Meeting on Bioorganic and Natural Products Chemistry 

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    Event date: 2003.9

    Language:English   Presentation type:Oral presentation (invited, special)  

  141. Total Synthesis of Optically Active Tetrodotoxin International conference

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    Event date: 2003.8

    Language:English   Presentation type:Oral presentation (general)  

  142. 新規糖アミノ酸α-C-マンノシルトリプトファンの合成と生物機能解析

    西川俊夫、梶井重男、和田享子、石川 幸、磯部 稔、佐藤ちひろ、安川然太、北島 健

    第24回日本糖質学会 

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    Event date: 2003.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  143. フグ毒テトロドトキシンの不斉全合成 --古くて新しい合成標的--(招待講演)

    西川俊夫

    有機合成化学協会中国四国支部、第55回パネル討論会 

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    Event date: 2003.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  144. 構造の特異な生理活性化合物の合成研究(奨励賞受賞講演)

    西川俊夫

    第82回有機合成シンポジウム(機能物質創製のための有機合成―新反応、新現象、新手法) 

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    Event date: 2002.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  145. Asymmetric total syntheses of 11-deoxytetrodotoxin and 8,11-dideoxytetrodotoxin International conference

    23rd International Symposium on the Chemistry of Natural Products 

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    Event date: 2002.8

    Language:English   Presentation type:Oral presentation (general)  

  146. フグ毒テトロドトキシン類の全合成研究

    西川俊夫

    文部科学省研究補助金特定領域研究「未解明生物現象鍵物質」第4回公開シンポジウム 

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    Event date: 2002.5

    Language:Japanese  

    ", 大阪"

  147. テトロドトキシン類の全合成とフグ毒の謎(依頼講演)

    7. 西川俊夫

    特別企画「生物現象鍵物質の合成と創製」.日本化学会春季年会 

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    Event date: 2002.3

    Language:Japanese  

    ", 東京"

  148. Asymmetric Total Synthesis of 11-deoxytetrodotoxin. International conference

    18th International Congress of Heterocylic Chemistry 

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    Event date: 2001.8

    Language:English  

    Yokohama Japan

  149. 新規なC-結合型糖鎖α-C-マンノシルトリプトファンとそのアナログの合成研究

    西川俊夫,和田享子,石川幸,磯部稔

    第6回FCCA糖質若手フォーラム 

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    Event date: 2001.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    "名古屋大学, 名古屋"

  150. 新規糖アミノ酸α-C-マンノシルトリプトファンとそのアナログの合成研究

    "西川俊夫,和田享子,石川幸,磯部稔"

    第79回有機合成シンポジウム(生物活性を目的とする有機合成-理論・方法論・技術開発) 

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    Event date: 2001.6

    Language:Japanese  

    ", 東京"

  151. Towards the Total Synthesis of Tetrodotoxins. International conference

    Institute Kolloquium der Universitaet Freiburg (Freiburg, Germany) 

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    Event date: 2000.5

    Language:English   Presentation type:Oral presentation (invited, special)  

  152. Synthetic Studies on Chiral Tetrodotoxin and its Analogs. International conference

    GDCh-Colloquium at Potsdam University (Potsdam, Germany) 

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    Event date: 2000.5

    Language:English   Presentation type:Oral presentation (invited, special)  

  153. Synthetic Studies on Puffer Fish toxins, Tetrodotoxin and its Analogs. International conference

    Organisch-Chemisches Kolloquium der Universitaet Stuttgart (Stuttgart, Germany) 

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    Event date: 2000.5

    Language:English   Presentation type:Oral presentation (invited, special)  

  154. Synthetic Studies on Chiral Tetrodotoxin and its Analogs. International conference

    GDCh-Colloquium at Wuerzburg University (Wuerzburg, Germany) 

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    Event date: 2000.5

    Language:English   Presentation type:Oral presentation (invited, special)  

  155. New C-Glycosidations and Their Application to Natural Products Syntheses. International conference

    Faculty Colloquium of Konstanz University (Konstanz, Germany) 

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    Event date: 2000.4

    Language:English   Presentation type:Oral presentation (invited, special)  

  156. Synthetic Studies on Chiral Tetrodotoxin and its Analogs.

    Institute Kolloquium der Universitaet Leipzig (Leipzig, Germany) 

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    Event date: 2000.4

    Language:English   Presentation type:Oral presentation (invited, special)  

  157. Synthetic studies on chiral tetrodotoxin and its analogs, toxic principle of pufferfish poisoning.

    Institute Kolloquium der Universitaet Tuebingen (Tuebingen, Germany) 

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    Event date: 2000.1

    Language:English   Presentation type:Oral presentation (invited, special)  

  158. 光学活性テトロドトキシンの全合成研究(依頼講演)

    西川俊夫

    日本化学会秋季大会シンポジウム「多不斉中心超生理活性物質の新合成戦略:化学合成および全合成」 

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    Event date: 1999.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    "北海道大学, 札幌"

  159. Stereocontrolled Synthesis of (-)-5,11-Dideoxytetrodotoxin International conference

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    Event date: 1999.8

    Language:English   Presentation type:Oral presentation (general)  

  160. Synthetic Studies of Tetrodotoxin and its Analogs as Biochemical Probes for Elucidation of the Molecular Mechanisms. International conference

    Nagoya COE Conference on Molecular Mechanisms of Biofunctions 

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    Event date: 1997.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

    Nagoya Japan

  161. Synthetic Studies on Cyclic Endiyne Antibiotic Dynemicin A. International conference

    The 1995 International Chemiical Congress of Pacific Basin Societies 

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    Event date: 1995.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

    Honolulu U.S.A.

  162. エンジイイン系抗腫瘍性抗生物質ダイネミシンAの合成研究

    西川俊夫,杢雅利,鈴木葉子,吉開真紀,小尾和代,磯部稔

    第68回有機合成シンンポジウム 

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    Event date: 1995.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    "全電通ホール, 東京"

  163. Synthetic Studies on cyclic enediyne antibiotic Dynemicin A and its Analogues

    The Chemistry of Natural Products, Symposium Papers 

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    Event date: 1993

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  164. 植物病原菌が作り出す新奇サイトカイニンの構造と機能の解明

    吉野実花、Akicia Surjana、小嶋美紀子、西川俊夫、榊原均

    第31回イソプレノイド研究会例会  2021.9.22 

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    Presentation type:Oral presentation (general)  

    Venue:名古屋・オンライン  

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Research Project for Joint Research, Competitive Funding, etc. 5

  1. イオンチャネルを阻害する天然毒素とその類縁体の化学合成

    2010.4 - 2011.3

  2. 含窒素多官能性生理活性物質の化学合成

    2005 - 2006.6

    医薬資源研究振興会助成金 

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    Grant type:Competitive

  3. 次世代型天然物合成を目指した基礎的研究

    2002.11 - 2006.3

    科学技術振興事業団さきがけ研究「合成と制御」領域 

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    Grant type:Competitive

  4. フグ毒テトロドトキシン類の全合成研究と生物機能解明

    2000.10

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    委任経理金

  5. 生物機能解明を目指したフグ毒テトロドトキシン類とその類縁体の合成研究

    1998.6

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    委任経理金

KAKENHI (Grants-in-Aid for Scientific Research) 22

  1. Practical one-pot synthesis of firefly luciferine and elucidation of the biosynthesis

    Grant number:23K17974  2023.6 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Principal investigator 

    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

  2. Elucidation of the biosynthesis mechanism of tetrodotoxin (TTX) - Importance of the toxic planocerid flatworms as a site of TTX production -

    Grant number:23H00347  2023.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s) 

  3. Molecular basis for the structural diversity and mode of action of cytokinins produced by plant pathogens

    Grant number:23H00324  2023.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s) 

  4. 有機合成化学を駆使したエンジイン抗生物質の生合成機構解明への挑戦

    Grant number:23H04553  2023.4 - 2025.3

    科学研究費助成事業  学術変革領域研究(A)

    西川 俊夫

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5980000 ( Direct Cost: \4600000 、 Indirect Cost:\1380000 )

    ネオカルチノスタチン, ダイネミシンA、カリチェアミシンなどの抗腫瘍性抗生物質は、9あるいは10員環エンジイン構造を有することから環状エンジイン抗生物質と呼ばれている。2000年代初頭に生合成酵素遺伝子クラスターが特定されたが、高歪みの環状エンジイン部分の生合成に関わる酵素の同定と機能解析はほとんど進んでいない。本研究では、これらエンジイン構造とダイネミシンAのアントラキノン構造は、全て「ポリイン中間体の連続反応によって一挙に生成する」という全く独自の生合成仮説を提唱し、この仮説の合理性を推定基質を化学合成して検証するとともに、この反応を触媒すると考えられる酵素を同定することを目的とする。

  5. Elucidation of structure and function of novel cytokinins produced by phytopathogen

    Grant number:19H00931  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s) 

  6. 天然物の網羅的合成による新たな生物機能の解明

    Grant number:19H02896  2019.4 - 2022.3

    科学研究費補助金  基盤研究(B)

    西川 俊夫

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    Authorship:Principal investigator  Grant type:Competitive

  7. Synthesis and biological evaluation of middle-size marine natural products

    Grant number:18H04400  2018.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  8. 天然物リガンドを利用した生体膜経由の化学

    2017.6 - 2022.3

    科学研究費補助金  新学術領域研究

    西川俊夫

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    Authorship:Coinvestigator(s) 

  9. Dynamic conformation and domain structure of lipid molecules in model biomembranes

    Grant number:17H06406  2017.6 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

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    Authorship:Coinvestigator(s) 

  10. フグによるテトロドトキシン認識の分子機構

    2017.6 - 2019.3

    科学研究費補助金  挑戦的萌芽研究

    西川俊夫

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    Authorship:Principal investigator 

  11. Elucidation of recognition mechanism of tetrodotoxin by puffer fish

    Grant number:17K19195  2017.6 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Nishikawa Toshio, Adachi Masaatsu

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    Authorship:Principal investigator 

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

    Because of the strong toxicity of tetrodotoxin (TTX), pufferfish uses TTX as a protective substance. On the other hand, there have been interesting reports that pufferfish are attracted to TTX. We thus first attempted to confirm that the TTX is actually sensed by the pufferfish olfactory organ by measuring an olfactory electrogram (EOG: electric field potential change generated when the olfactory epithelium is stimulated with an odorant). Unexpectedly, a strong EOG response was observed for a non-toxic analog of TTX rather than toxic TTX. We then synthesized several related compounds of the TTX analog for structure-activity relationship studies, and attempted behavior experiment using pufferfish, and to identify attractive olfactory cell species that receive the TTX analog.

  12. Collective synthesis of biologically active natural products by means of cascade reaction

    Grant number:16H04915  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Nishikawa Toshio, Adachi Masaatsu

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    Authorship:Principal investigator 

    Grant amount:\17680000 ( Direct Cost: \13600000 、 Indirect Cost:\4080000 )

    The purpose of this study is to establish new synthetic method of natural products and their analogues by developing new cascade reactions, which enable to construct their core structures in efficient manners. For synthesis of saxitoxin (STX) skeleton of zetekitoxin, a dart frog toxin, a cascade bromocyclization of an internal alkyne possessing guanidine and carbamate was newly developed and used for synthesis of its analogue. In the synthesis of peramine, an endophyte toxin, we developed a one-pot synthetic method of its pyrrolopyrazinone core structure by N-akynylation of pyrrole amide with propargyl bromide, and achieved the total synthesis. Chaxines, steroidal natural products isolated from a Chinese mushroom, was synthesized in 7 steps from ergosterol by a newly developed oxidative cascade from a furan intermediate, giving a variety of the analogs.

  13. 生物活性テルペンインドールアルカロイドの新合成方法論の開発

    2012.4 - 2016.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  14. 特異なヘテロ多環構造を含んだ生理活性天然物の合成研究              

    2008

    科学研究費補助金  基盤研究(B),課題番号:20380067

    西川 俊夫

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    Authorship:Principal investigator 

  15. 合成プローブを活用したテトロドトキシンの食物連鎖機構および生合成経路の解明

    2006 - 2008

    科学研究費補助金  基盤研究(C)(一般),課題番号:18510182

    西川 俊夫

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    Authorship:Principal investigator 

  16. 生理活性発現機構に基づく生物活性物質の創製

    2004.11 - 2009.3

    科学研究費補助金  特別推進研究

    磯部 稔

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    Authorship:Coinvestigator(s) 

  17. 新規微量糖鎖成分C-マンノシルトリプトファンの生物機能の解明

    2003.4 - 2004.3

    科学研究費補助金  特定領域研究(A)糖鎖によるタンパク質と分子複合体の機能調節

    西川俊夫

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    Authorship:Principal investigator 

  18. フグ毒テトロドトキシン類の全合成とその生物機能解析

    2001.4 - 2003.3

    科学研究費補助金  特定領域研究(A)(2)(公募)

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    Authorship:Principal investigator 

    科研費

  19. 糖とタンパクの新規な結合様式C-マンノシルトリプトファンの合成と生物機能の解明

    2000.1 - 2002.12

    科学研究費補助金  奨励研究(A)

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    Authorship:Principal investigator 

    科研費

  20. フグ毒テトロドトキシンの生物機能解明を目指した化学合成研究

    1998.1 - 1999.12

    科学研究費補助金  奨励研究(A)

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    Authorship:Principal investigator 

    科研費

  21. 抗腫瘍性抗生物質ダイネミシンAをモデルにしたDNA切断分子の設計と化学合成

    1995.1 - 1996.12

    科学研究費補助金  奨励研究(A)

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    Authorship:Principal investigator 

    科研費

  22. タンパク脱りん酸化酵素阻害トートマイシンの作用機作に関する化学的研究

    1994.1 - 1996.12

    科学研究費補助金  一般研究(B)

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    Authorship:Coinvestigator(s) 

    科研費

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Industrial property rights 2

  1. 害虫に対する忌避・殺虫剤およびこの製造方法

    宮崎雅雄、西川俊夫、上野山怜子

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    Applicant:国立大学法人岩手大学、東海国立大学機構名古屋大学

    Application no:2020-140755  Date applied:2020.8

  2. 新規な環状エンジイン抗腫瘍剤

    磯部 稔、西川俊夫、海野良一、稲垣英晃、城森孝仁、道下久

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    Applicant:(株)三和化学研究所

    Application no:5-217491  Date applied:1993.9

    Announcement no:7-70130 

    Date registered:1995.3 

    Country of applicant:Domestic  

 

Teaching Experience (On-campus) 23

  1. Bioorganic Chemistry

    2023

  2. 有機化学1

    2011

  3. Bioorganic Chemistry

    2023

  4. 生物有機化学

    2011

  5. 生命機能化学特論I

    2011

  6. 有機化学2

    2011

  7. 生命機能化学基盤実験

    2011

  8. 生命機能化学基盤講義

    2011

  9. 基礎有機化学

    2011

  10. 生命機能化学演習I

    2011

  11. 生命機能化学輪講I

    2011

  12. Organic Chemistry 4

    2023

  13. Bioorganic Chemistry

    2023

  14. Organic Chemistry 3

    2023

  15. Organic Chemistry 1

    2023

  16. Synthetic Organic Chemistry

    2023

  17. Organic Chemistry 4

    2022

  18. Bioorganic Chemistry

    2022

  19. Synthetic Organic Chemistry

    2022

  20. Organic Chemistry 3

    2022

  21. Organic Chemistry 1

    2022

  22. Bioorganic Chemistry

    2020

  23. 有機合成化学特論

    2020

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Teaching Experience (Off-campus) 9

  1. 天然物合成の基礎

    2007.4 - 2008.3 名古屋工業大学)

  2. 天然物合成

    2009.4 - 2010.3 明治薬科大学)

  3. 天然物合成

    2011.4 - 2012.3 Kwansei Gakuin University)

  4. 天然物合成化学

    2012.4 - 2013.3 Hiroshima University)

  5. 天然物合成化学

    2012.4 - 2013.3 University of Tsukuba)

  6. 天然物合成化学

    2013.4 - 2014.3 Tokyo Institute of Technology)

  7. 天然物合成化学

    2013.4 - 2014.3 Chiba University)

  8. 天然物合成化学

    2014.4 - 2015.3 Kobe University)

  9. 天然物合成化学

    2023.6 Tohoku University)

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    Level:Postgraduate  Country:Japan

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Media Coverage 14

  1. なぜネコはマタタビにじゃれつくのか 日本、英国のネコ好き研究者の執念

    Yahoo!ニュース デイリー  Yahoo!ニュース デイリー  2024.2

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    Author:Myself 

  2. フグ毒の秘密分かった Newspaper, magazine

    中日新聞  中日新聞  2022.10

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    Author:Other 

  3. 毒に類似の物質がフグ誘引 フェロモンの役割か Newspaper, magazine

    中部経済新聞  中部経済新聞  2022.10

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    Author:Other 

  4. 毒に類似物質、フグが異性誘うフェロモンか Newspaper, magazine

    産経ニュース  産経ニュース  2022.10

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    Author:Other 

  5. かめば効果ニャン倍 Newspaper, magazine

    中日新聞 東京新聞  中日新聞 東京新聞  2022.6

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    Author:Other 

  6. 食べないのになぜかむの?〜「猫にマタタビ」岩手大などの研究チームが新たな謎を解明 Newspaper, magazine

    TBS NEWS DIG 2022  TBS NEWS DIG 2022  2022.6

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    Author:Other 

  7. 「猫にマタタビ」謎解明、歯をかむことで蚊よけ効果アップ…「身を守るため巧みに進化か」 Newspaper, magazine

    読売新聞  読売新聞  2022.6

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    Author:Other 

  8. マタタビの葉、かむと効果増強 ネコに幸福感、蚊よけ-有効成分の比率変化・岩手大と名大 Newspaper, magazine

    時事ドットコムニュース  時事ドットコムニュース  2022.6

  9. マタタビ 、かむと効果アップ Newspaper, magazine

    岐阜新聞  岐阜新聞  2022.6

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    Author:Other 

  10. 数百年の疑問、ついに解決!「ネコにマタタビ」解明への道(前半、後半) Internet

    Bun-ichi Nature Web Magazin  https://buna.info/article/4605/、https://buna.info/article/4618/  2021.2

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    Author:Myself 

  11. マタタビとは TV or radio program

    CBCラジオ  CBCラジオ  多田茂雄の気分爽快〜朝からP.O.N   2021.2

  12. 「ネコにマタタビ 」実は蚊よけ Newspaper, magazine

    毎日新聞  朝刊21面  2021.1

  13. マタタビ 反応で蚊除け Newspaper, magazine

    日刊工業新聞  朝刊25面  2021.1

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    Author:Other 

  14. マタタビ 愛 謎解明  Newspaper, magazine

    中日新聞  朝刊29面  2020.1

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    Author:Other 

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Academic Activities 1

  1. 第62回天然有機化合物討論会 International contribution

    Role(s):Planning, management, etc.

    実行委員長  2020.9

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    Type:Competition, symposium, etc.