Updated on 2024/04/16

写真a

 
ODA, Hiroaki
 
Organization
Graduate School of Bioagricultural Sciences Department of Applied Biosciences Associate professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences
Title
Associate professor
Contact information
メールアドレス

Degree 2

  1. 農学博士 ( 1991.3   名古屋大学 ) 

  2. 農学修士 ( 1985.3   名古屋大学 ) 

Research Interests 16

  1. 時間栄養学

  2. personalized nutrition

  3. precision nutrition

  4. スクロース

  5. 脂肪肝

  6. Circadian rhythm

  7. 3-dimensional cell culture

  8. Gene expression

  9. Hepatocytes

  10. Liver

  11. Amino acids

  12. Food

  13. Nutrition

  14. 腸内細菌叢

  15. フルクトース

  16. 時間生物学

Research Areas 3

  1. Others / Others  / Applied Biochemistry

  2. Others / Others  / Food Science

  3. Others / Others  / Applied Molecular Cell Biology

Current Research Project and SDGs 10

  1. 時間栄養学 食事のタイミングと健康 メタボリックシンドロームの予防

  2. precision nutrition

  3. 食の5W1Hと健康

  4. 寝たきりモデル動物の開発と寝たきり状態によって起きる代謝異常のメカニズム解析を通した寝たきりからの復帰を目指した食品成分の探索

  5. Molecular mechanism of liver-specific gene expression in cultured hepatocytes

  6. 肝細胞の日周リズムの発振機構とその生理的意義

  7. 細胞外マトリクス、細胞形態による肝臓特異的転写因子HNF-4の制御

  8. Nutritional regulation and molecular mechanism of changes in gene expression by redox

  9. Transcriptional regulation of apolipoprotein A-I gene

  10. スクロース・フルクトースによる脂質代謝異常の新パラダイム

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Research History 4

  1. 名古屋大学大学院生命農学研究科准教授

    2007.4

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    Country:Japan

  2. 名古屋大学農学部 助教授

    1997.5

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    Country:Japan

  3. 米国ケース・ウェスタン・リザーブ大学医学部生化学科 留学

    1991.3 - 1992.8

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    Country:Japan

  4. 名古屋大学農学部 助手

    1987.12 - 1997.4

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    Country:Japan

Education 3

  1. Nagoya University   Graduate School, Division of Agriculture

    1985.4 - 1987.11

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    Country: Japan

  2. Nagoya University   Graduate School, Division of Agriculture

    - 1985.3

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    Country: Japan

  3. Nagoya University   Faculty of Agriculture

    1979.4 - 1983

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    Country: Japan

Professional Memberships 7

  1. 日本栄養・食糧学会   理事、中部支部支部長、中部支部会計

    1996.4

  2. 日本農芸化学会   中部支部庶務幹事、中部支部会計

    1994.4 - 1996.3

  3. 日本動物細胞工学会

  4. 日本生化学会

  5. 日本分子生物学会

  6. 日本アミノ酸学会   評議員

  7. 日本時間栄養学会   役員

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Awards 8

  1. Society award

    2023.5  

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    Award type:Award from Japanese society, conference, symposium, etc. 

  2. 日本農芸化学会奨励賞受賞

    2001.3   社団法人日本日本農芸化学会  

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    Country:Japan

  3. 日本栄養・食糧学会 奨励賞

    1995.5   日本栄養・食糧学会  

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    Country:Japan

  4. 第77回日本栄養・食糧学会大会トピックス賞

    2023.5   日本栄養・食糧学会  

  5. 日本農芸化学会2019年度大会トピックス賞

    2019.3   日本農芸化学会  

  6. 日本農芸化学会2017年大会トピックス賞

    2017.3   日本農芸化学会   朝食欠食モデルラットに高脂肪食を与えた場合の体脂肪および肝臓代謝リズムの変動

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  7. 第15回オレオサイエンス賞

    2016.9   日本油化学会   不規則な摂食タイミングが肝臓概日時計異常とコレステロール代謝異常を導く分子メカニズムの解析

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  8. 日本農芸化学会2011年大会トピックス賞

    2011.3   日本農芸化学会   寝たきりモデル動物における肝障害・脂質代謝異常機構のメタボローム解析

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Papers 142

  1. C3H/HeNSlc mouse with low phospholipid transfer protein expression showed dyslipidemia Reviewed

    Kobayashi, M, Fumi Kanbe 2, Reika Ishii 2, Hiroki Tsubouchi 2, Kana Hirai 2, Yuki Miyasaka 3, Tamio Ohno 3, Hiroaki Oda 4, Saiko Ikeda 1, Hirokazu Katoh 2, Kenji Ichiyanagi 2, Akira Ishikawa 2, Atsushi Murai, A. and Fumihiko Horio, F.

    Sci. Rep.   Vol. 13   page: 13813   2023.9

  2. High sucrose diet-induced abnormal lipid metabolism in mice is related to the dysbiosis of gut microbiota

    Fu, Y; Araki, Y; Hanzawa, F; Nishimura, N; Ikeda, S; Mochizuki, S; Oda, H

    ANNALS OF NUTRITION AND METABOLISM   Vol. 79   page: 748 - 748   2023.8

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  3. Taurine Alleviated Hepatic Steatosis in Oleic Acid-Treated-HepG2 Cells and Rats Fed a High-Fat Diet

    Song, Q; Ma, YX; Ou, T; Guo, JX; Mi, SQ; Zhang, YZ; Oda, H; Chen, W

    ANNALS OF NUTRITION AND METABOLISM   Vol. 79   page: 1100 - 1100   2023.8

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  4. Taurine alleviated hepatic steatosis in oleic acid-treated-HepG2 cells and rats fed a high-fat diet

    Song, Q; Guo, JX; Ma, YX; Ou, T; Zhang, J; Li, HZ; Mi, SQ; Zhang, YZ; Oda, H; Chen, W

    HELIYON   Vol. 9 ( 6 ) page: e16401   2023.6

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  5. Lyoprotectant Formulation and Optimization of the J-Aggregates Astaxanthin/BSA/Chitosan Nanosuspension Reviewed

    Zhao, YY; Wang, ZX; Liu, SX; Xie, SY; Xie, YC; Li, RF; Oda, H

    BIOMOLECULES   Vol. 13 ( 3 )   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/biom13030496

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    PubMed

  6. Delayed feeding of a high-sucrose diet led to increased body weight by affecting the circadian rhythm of body temperature and hepatic lipid-metabolism genes in rats Reviewed

    Kim, D; Hanzawa, F; Shimizu, H; Sun, SM; Umeki, M; Ikeda, S; Mochizuki, S; Oda, H

    JOURNAL OF NUTRITIONAL BIOCHEMISTRY   Vol. 111   page: 109185   2023.1

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  7. Fabrication and characterization of the H/J-type aggregates astaxanthin/bovine serum albumin/chitosan nanoparticles Reviewed

    Zhao, YY; Liu, JX; Zhang, SM; Wang, ZX; Jia, HH; Oda, H; Li, RF

    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES   Vol. 223 ( Pt A ) page: 1186 - 1195   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijbiomac.2022.11.006

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  8. Skipping breakfast regimen induces an increase in body weight and a decrease in muscle weight with a shifted circadian rhythm in peripheral tissues of mice Reviewed

    Kiriyama, K; Yamamoto, M; Kim, D; Sun, SM; Yamamoto, H; Oda, H

    BRITISH JOURNAL OF NUTRITION   Vol. 128 ( 12 ) page: 2308 - 2319   2022.12

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  9. Characterization and Antioxidant Activity of Mannans from <i>Saccharomyces cerevisiae</i> with Different Molecular Weight

    Zhao, YY; Wang, JQ; Fu, QZ; Zhang, HR; Liang, J; Xue, WJ; Zhao, GQ; Oda, H

    MOLECULES   Vol. 27 ( 14 )   2022.7

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  10. Delayed Meal Timing, a Breakfast Skipping Model, Increased Hepatic Lipid Accumulation and Adipose Tissue Weight by Disintegrating Circadian Oscillation in Rats Fed a High-Cholesterol Diet Reviewed

    Kim, D; Hanzawa, F; Sun, SM; Laurent, T; Ikeda, S; Umeki, M; Mochizuki, S; Oda, H

    FRONTIERS IN NUTRITION   Vol. 8   page: 681436   2021.7

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  11. High sucrose diet-induced dysbiosis of gut microbiota promotes fatty liver and hyperlipidemia in rats Reviewed

    Sun, SM; Araki, Y; Hanzawa, F; Umeki, M; Kojima, T; Nishimura, N; Ikeda, S; Mochizuki, S; Oda, H

    JOURNAL OF NUTRITIONAL BIOCHEMISTRY   Vol. 93   page: 108621   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jnutbio.2021.108621

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  12. Yuzu, <i>Citrus junos</i>, peels extract ameliorated hepatic steatosis induced by chloretone in rats

    Suzuki, A; Hirakawa, E; Umeki, M; Sakai, K; Koya, M; Oda, H; Mochizuki, S; Nobuoka, K; Ishikawa, Y

    FOOD SCIENCE AND TECHNOLOGY RESEARCH   Vol. 27 ( 2 ) page: 281 - 292   2021.3

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    Language:Japanese  

    DOI: 10.3136/fstr.27.281

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  13. Suppressive Effect Effect of Yuzu (<i>Citrus junos</i>) Peel Extract on Fatty Liver Steatosis Induced by a High-sucrose Diet in Rats

    Suzuki, A; Miyajima, S; Mochizuki, S; Umeki, M; Sakai, K; Koya, M; Oda, H; Nobuoka, K; Ishikawa, Y

    JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI   Vol. 68 ( 5 ) page: 197 - 205   2021

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    Language:Japanese  

    DOI: 10.3136/nskkk.68.197

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  14. Transcriptional Activation of <i>Chac1</i> and Other Atf4-Target Genes Induced by Extracellular l-Serine Depletion is negated with Glycine Consumption in Hepa1-6 Hepatocarcinoma Cells

    Hamano, M; Tomonaga, S; Osaki, Y; Oda, H; Kato, H; Furuya, S

    NUTRIENTS   Vol. 12 ( 10 )   2020.10

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  15. Gut Microbiota Is Not Involved in the Induction of Acute Phase Protein Expression Caused by Vitamin C Deficiency

    Ikeda, S; Takahashi, S; Suzuki, N; Hanzawa, F; Horio, F; Oda, H

    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY   Vol. 66 ( 1 ) page: 19 - 23   2020

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  16. 肝臓と時間栄養学 Invited Reviewed

    小田裕昭、中島俊

    食と医療   Vol. 12   page: 18 - 24   2020

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  17. Circadian rhythm?dependent induction of hepatic lipogenic gene expression in rats fed a high-sucrose diet

    Sun, SM; Hanzawa, F; Kim, D; Umeki, M; Nakajima, S; Sakai, K; Ikeda, S; Mochizuki, S; Oda, H

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 294 ( 42 ) page: 15206 - 15217   2019.10

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  18. Impacts of high-sucrose diet on circadian rhythms in the small intestine of rats

    Sun, SM; Hanzawa, F; Umeki, M; Matsuyama, Y; Nishimura, N; Ikeda, S; Mochizuki, S; Oda, H

    CHRONOBIOLOGY INTERNATIONAL   Vol. 36 ( 6 ) page: 826 - 837   2019.6

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  19. 時間栄養学からみた糖尿病・メタボリックシンドローム Invited Reviewed

    小田裕昭、孫淑敏、金多恩

    プラクティス   Vol. 36   page: 1 - 8   2019

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  20. 肝臓の機能と肝ケア成分の探索 Invited Reviewed

    小田裕昭

    FOOD Style 21     2019

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    Authorship:Lead author, Corresponding author   Language:Japanese  

  21. Delayed first active-phase meal, a breakfast-skipping model, led to increased body weight and shifted the circadian oscillation of the hepatic clock and lipid metabolism-related genes in rats fed a high-fat diet

    Shimizu, H; Hanzawa, F; Kim, D; Sun, S; Laurent, T; Umeki, M; Ikeda, S; Mochizuki, S; Oda, H

    PLOS ONE   Vol. 13 ( 10 ) page: e0206669   2018.10

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  22. Time-restricted feeding suppresses excess sucrose-induced plasma and liver lipid accumulation in rats

    Sun Shumin, Hanzawa Fumiaki, Umeki Miki, Ikeda Saiko, Mochizuki Satoshi, Oda Hiroaki

    PLOS ONE   Vol. 13 ( 8 ) page: e0201261   2018.8

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    DOI: 10.1371/journal.pone.0201261

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  23. α-Tocopherol Intake Decreases Phylloquinone Concentration in Bone but Does Not Affect Bone Metabolism in Rats

    Ikeda, S; Nomura, S; Hanzawa, F; Takahashi, S; Oda, H; Fujiwara, Y; Uchida, T

    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY   Vol. 64 ( 4 ) page: 243 - 250   2018

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    DOI: 10.3177/jnsv.64.243

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  24. γ-Tocopherol Is Metabolized Faster than α-Tocopherol in Young Japanese Women

    Uchida, T; Nomura, S; Oda, H; Ikeda, S

    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY   Vol. 64 ( 6 ) page: 399 - 403   2018

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  25. Tissue Distribution of Menaquinone-7 and the Effect of α-Tocopherol Intake on Menaquinone-7 Concentration in Rats

    Ikeda, S; Hanzawa, F; Takahashi, S; Suzuki, N; Sano, K; Oda, H; Uchida, T

    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY   Vol. 64 ( 6 ) page: 391 - 398   2018

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  26. 時間栄養学 -時計遺伝子とメタボリック・シンドローム予防- Invited Reviewed

    ひと・健康・未来   Vol. 19   page: 30-35   2018

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  27. 時間栄養学 -食事のタイミングと健康- Invited

    小田裕昭

    食品の包装   Vol. 48   page: 57-61   2017.2

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    Authorship:Lead author   Language:Japanese  

  28. 不規則な摂食タイミングが肝臓概日時計異常とコレステロール代謝異常を導く分子メカニズムの解析 Invited

    小田裕昭

    オレオサイエンス   Vol. 15   page: 61-67   2015.2

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    Authorship:Lead author   Language:Japanese  

  29. Identification of an interaction between VWF rs7965413 and platelet count as a novel risk marker for metabolic syndrome: an extensive search of candidate polymorphisms in a case-control study Reviewed

    Nakatochi, M., Yasunori Ushida, Y., Yasuda, Y., Yoshida, Y., Kawai, S., Kato, R., Nakashima, T., Iwata, M., Kuwatsuka, Y., Ando, M., Hamajima, N., Kondo, T., Oda, H., Hayashi, M., Kato, S., Yamaguchi, M., Maruyama, S., Matsuo, S., Honda, H.

        page: 1-9   2015.1

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  30. 時間栄養学とメタボリックシンドローム(1) Invited

    小田裕昭

    全栄施協月報   Vol. 652   page: 9-25   2015

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    Authorship:Lead author   Language:Japanese  

  31. Phenobarbital reduces blood glucose and gluconeogenesis through down-regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression in rats Reviewed

    Oda, H., Okuda, Y., Yoshida, Y., Kimura, N. and Kakinuma, A.

    Biochem. Biophys. Res. Commun.   Vol. 466   page: 306-311   2015

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  32. Dietary freshwater clam (Corbicula fluminea) extract suppresses accumulation of hepatic lipids and increases in serum cholesterol and aminotransferase activities induced by dietary chloretone in rats Reviewed

    Chijimatsu, T., Umeki, M., Kobayashi, S., Kataoka, Y., Yamada, K., Oda, H. and Satoshi Mochizuki, S.

    Biosci. Biotechnol. Biochem.   Vol. 79   page: 1155-1163   2015

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  33. Chrononutrition Invited Reviewed

    Oda, H.

      Vol. 61   page: S92-S94   2015

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    Authorship:Lead author   Language:English  

  34. 時間栄養学とメタボリックシンドローム(2) Invited

    小田裕昭

    全栄施協月報   Vol. 653   page: 7-28   2015

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    Authorship:Lead author   Language:Japanese  

  35. がんとアミノ酸代謝 Invited Reviewed

    小田裕昭

    生化学   Vol. 86   page: 332-337   2014.6

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    Authorship:Lead author   Language:Japanese  

  36. 時計遺伝子とメタボリック・シンドローム Invited

    小田裕昭

    薬剤師会雑誌   Vol. 66   page: 567-571   2014

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    Authorship:Lead author   Language:Japanese  

  37. Excess a-tocopherol decreases extrahepatic phylloquinone in phylloquinone-fed rats but not Reviewed

    Hanzawa, F., Sakuma, E., Nomura, S., Uchida, T. Oda, H. and Ikeda, S.

    Mol. Nutr. Food Res.   Vol. 22   page: 1-9   2014

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  38. 時計遺伝子と食事のリズム -メタボリックシンドロームにならないために- Invited

    小田裕昭

    大阪市役所医師会報   Vol. 130   page: 12-15   2014

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    Authorship:Lead author   Language:Japanese  

  39. Freshwater clam extract ameliorates triglyceride and cholesterol metabolism through the expression of genes involved in hepatic lipogenesis and cholesterol degradation in rats

    Laurent, T., Okuda, Y., Chijimatsu, T., Umeki, M., Kobayashi, S., Kataoka, Y., Tatsuguchi, I., Mochizuki, S. and Oda, H.

    Evidence-Based Complementary and Alternative Medicine     2013.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2013/830684

  40. Lipid components prepared from a freshwater clam (Corbicula fluminea) extract ameliorate hypercholesterolemia in rats fed high-cholesterol diet Reviewed

    Chijimatsu, T., Umeki, M., Kataoka, Y., Kobayashi, S, Yamada, K., Oda, H. and Mochizuki, S.

    Food Chem.   Vol. 136   page: 328-334   2013.1

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  41. 肝臓時計の新規同調因子として働くインスリンと生活習慣病予防 -腹時計の大切な働き- Invited Reviewed

    小田裕昭

    化学と生物   Vol. 51   page: 518-520   2013

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    Authorship:Lead author   Language:Japanese  

  42. 二枚貝、特にシジミの機能性に関する研究 Invited Reviewed

    千々松武司、山田耕史、小田裕昭、望月聡.

    New Food Industry   Vol. 55   page: 23-31   2013

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  43. 必須アミノ酸の起源 -遺伝子進化におけるリジン合成遺伝子群の欠損と再獲得-

    小田裕昭

    アミノ酸研究   Vol. 7   page: 107-113   2013

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  44. Spherical cell shape of FLC-4 cell, a human hepatoma cell, enhances hepatocyte-specific function and suppresses tumor phenotype through the integration of mRNA-microRNA interaction Reviewed

    Laurent, T., Kataoka, Y., Kobayashi, S., Ando, M., Nagamori, S. and Oda, H.

    Biol. Open   Vol. 1   page: 958-964   2012.9

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  45. *Real-time monitoring in three-dimensional hepatocytes reveals that insulin acts as a synchronizer for liver clock Reviewed

    Scientific Rep.   Vol. 2   page: 439   2012.6

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    DOI: DOI:10.1038/srep00439

  46. A novel human hepatoma cell line, FLC-4, exhibits highly enhanced liver differentiation functions through the three-dimensional cell shape Reviewed

    Laurent, T., Murase, D., Tsukioka1, S., Matsuura, T., Nagamori, S. and Oda, H.

    J. Cell. Physiol.   Vol. 227   page: 2898-2906   2012

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  47. The fat and protein fractions of freshwater clam (Corbicula fluminea) extract reduce serum cholesterol, and enhance bile acid biosynthesis and sterol excretion in hypercholesterolaemic rats fed a high-cholesterol diet. Reviewed

    Chijimatsu, T., Umeki, M., Okuda, Y., Yamada, K., Oda, H. and Mochizuki, S.

    Brit. J. Nutr.   Vol. 105   page: 526-534   2011

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  48. Advantages of human hepatocyte-derived transformants expressing a series of human cytochrome P-450 isoforms for genotoxicity examination. Reviewed

    Hashizume, T., Yoshitomi, S., Asahi, S., Uematsu, R., Matsumura, S., Chatani, F. and Oda, H.

      Vol. 116   page: 488-497   2010

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  49. コレステロールの日内変動は? Invited

    小田裕昭

    肥満と糖尿病   Vol. 9   page: 295-297   2010

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  50. A freshwater clam (Corbicula fluminea) extract reduces cholesterol level and hepatic lipids in normal rats and xenobiotics-induced hypercholesterolemic rats. Reviewed

    Chijimatsu, T., Tatsuguchi, I., Oda, H. and Mochizuki, S.

      Vol. 57   page: 3108-3112   2009

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  51. *Regular feeding plays an important role in cholesterol homeostasis through the liver circadian clock. Reviewed

    Yamajuku, D., Okubo, S., Haruma, T., Inagaki, T., Okuda, Y., Kojima T, Noutomi, K., Hashimoto, S. and Oda, H.

    Circulation Res.   Vol. 105   page: 545-548   2009

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  52. In vitro micronucleus test in HepG2 transformants expressing a series of human cytochrome P450 isoforms with chemicals requiring metabolic activation. Reviewed

    Hashizume, T., Yoshitomi, S., Asahi, S., Matsumura, S., Chatani, F. and Oda, H.

    Mutation Res.   Vol. 677   page: 1-7   2009

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  53. *Cell shape, cell-cell contact, cell-extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes. Submitted to Reviewed

    Oda, H., Yoshida, Y., Kawamura, A. and Kakinuma, A.

    Biochem. Pharmacol.   Vol. 75   page: 1209-1217   2008

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  54. タイワンシジミ抽出物がラットの肝機能に及ぼす影響. Reviewed

    千々松武司、山田亜希子、宮木寛子、吉永智子、村田夏紀、秦政博、阿部和明、小田裕昭、望月聡

    日本食品科学工学会誌   Vol. 55 ( 63-68 )   2008

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    タイワンシジミ抽出物に肝保護作用があることを示した。

  55. 肝細胞の日周リズムとコレステロール代謝. Invited

    小田裕昭、山宿大介

    日本医事新報   Vol. 4417   page: 45-48   2008

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  56. Freshwater clam (Corbicula fluminea) extract improves cholesterol metabolism in rats fed a high-cholesterol diet Reviewed

      Vol. 72   page: 2566-2571   2008

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  57. アミノ酸によるコレステロール代謝の制御

    小田裕昭

    化学と生物   Vol. 45   page: 347-354   2007

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  58. 必須アミノ酸、非必須アミノ酸 その2つを分けるもの

    小田裕昭

    日本栄養・食糧学会誌   Vol. 60   page: 137-149   2007

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  59. Effects of taurine on mRNA levels of nuclear receptors and factors involved in cholesterol and bile acid homeostasis in mice. Reviewed

    Lam, N. V., Chen, W., Suruga, K., Nishimura, N., Goda, T., Oda, H. and Yokogoshi, H.

    Adv. Exp. Med. Biol.   Vol. 583   page: 193-202   2006

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  60. グリシンによるCYP7A1遺伝子発現の誘導機構

    小田裕昭、藤吉智治、岩田剛幸、荒川真悟

    必須アミノ酸研究   Vol. 182   page: 43-47   2006

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  61. *Functions of sulfur-containing amino acids on lipid metabolism Reviewed

    Oda, H.

    J. Nutr.   Vol. 136   page: 1666S-1669S   2006

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    これまで一般に、植物性タンパク質は血中コレステロールを下げると知られているが、その作用は十分に分かっていなかった。著者は、その原因の一つをアミノ酸組成であると考えて研究を行った。含硫アミノ酸にはコレステロール代謝を強く制御する機能があることがわかり、それぞれの含硫アミノ酸によってその強さが異なることを示した。含硫アミノ酸の余剰度を指標に、食品タンパク質のアミノ酸組成から血中コレステロール濃度に与える影響を推測する指標(アミノ酸による脂質改善指数)を考案し提案した。

  62. バイオ人工肝 −実用化のための基本的な条件−

    永森靜志、小田裕昭、宮崎正博、秋山一郎、細川正清、千葉 寛、相崎英樹、村上恭子、鈴木哲朗

    肝胆膵   Vol. 51   page: 107-120   2005

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  63. 肝細胞の形態による分化制御機構の解析と日周リズム

    バイオサイエンスとインダストリー   Vol. 63   page: 97-100   2005

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  64. The effect of taurine on cholesterol metabolism in rats fed diets supplemented with cholestyramine or high amount of bile acid. Reviewed

    Nishimura, N., Umeda, C., Oda, H. and Yokogoshi, H.

    J. Nutr. Sci. Vitaminol.   Vol. 49   page: 21-26   2003

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  65. Effect of taurine on cholesterol degradation and bile acid pool in rats fed a high-cholesterol diet. Reviewed

    Chen, W., Nishimura, N., Oda, H. and Yokogoshi, H.

    Adv. Exp. Med. Biol.   Vol. 526   page: 261-267   2003

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  66. Small scale rat hepatocyte culture with applications for screening hepatoprotective substances. Reviewed

    Nakagiri, R., Oda, H. and Kamiya, T.

    Biosci. Biotechnol. Biochem.   Vol. 65   page: 1629-1635   2003

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  67. 食品中の肝保護物質のマイクロスクリーニング法

    中桐竜介、小田裕昭、神谷俊和

    日本農芸化学会誌   Vol. 77   page: 1248-1251   2003

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  68. 生活習慣病の予防・改善を目指した「食」と「栄養」のバイオサイエンス. はじめに

    関 泰一郎、小田裕昭

    日本農芸化学会誌   Vol. 77   page: 1108-1109   2003

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  69. 肝臓の機能と「食」と「栄養」のバイオサイエンス −肝臓を守る食品、肝機能を強化する栄養、肝機能の利用−

    小田裕昭

    日本農芸化学会誌   Vol. 77   page: 1116-1119   2003

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  70. 卵白タンパク質による血中脂質改善効果の作用機序

    "小田裕昭,林直紀"

    FOOD Style 21   Vol. 6   page: 54-58   2002.1

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  71. 卵白タンパク質によるコレステロール代謝改善効果のメカニズム

    "小田裕昭,荒川真悟,林直紀"

    必須アミノ酸研究   Vol. 163   page: 29-34   2002.1

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  72. Dietary taurine enhances cholesterol degradation and reduces serum and cholesterol concentrations in rats fed a high cholesterol diet. Reviewed

    Yokogoshi, H. and Oda, H.

    Amino Acids   Vol. 23   page: 433-439   2002

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    タンパク質に取り込まれないアミノ酸であり、非必須のアミノ酸であるタウリンには、いくつかの生理作用が報告されている。今回私たちは、タウリンの血中コレステロール低下作用を明らかにし、その作用がタウリンが遺伝子働きかけることで起こることを示した。タウリンを摂取させた高コレステロール血症モデルラットでは、肝臓のコレステロール異化代謝の律速酵素であるCYP7A1遺伝子発現を顕著に亢進した。これが、タウリンによるコレステロール低下作用の原因であることが分かった。

  73. Effect of taurine on plasma cholesterol concentration in genetically type 2 diabetic rats, GK rats. Reviewed

      Vol. 48   page: 483-490   2002

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  74. ヒト肝細胞と肝臓特異的転写因子

    小田裕昭、永森靜志

    細胞   Vol. 34   page: 545-549   2002

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  75. ヒト培養肝細胞の肝機能発現とその利用法 −バイオ人工肝の多角的な応用をめざして−.

    永森靜志、遠藤 仁、金井好克、宮崎正博、本間正充、宮村達男、鈴木哲朗、相崎英樹、梅田 誠、田中憲穂、佐々木澄志、千葉 寛、細川正清、松浦知和、小田裕昭、吉田 彪

    細胞   Vol. 34   page: 516-523   2002

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  76. 培養肝細胞の機能維持に関する細胞生物学的・分子生物学的研究

    小田裕昭

    日本農芸化学会誌   Vol. 75   page: 1267-1274   2001.12

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  77. 肝実質細胞の機能調節機構とその制御

    小田裕昭

    細胞   Vol. 33   page: 402-405   2001.10

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  78. 生体異物摂取時の高コレステロール血症に対して-タウリンのHDL代謝に及ぼす影響-

    "小田裕昭,横越英彦"

    日本農芸化学会誌   Vol. 75   page: 961-963   2001.9

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  79. 糖尿病性高コレステロール血症に対するタウリンの作用

    "西村直道,小田裕昭,横越英彦"

    日本農芸化学会誌   Vol. 75   page: 968-971   2001.9

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  80. 食餌性高コレステロール血症におけるタウリンのコレステロール低下作用

    "横越英彦,西村直道,小田裕昭"

    日本農芸化学会誌   Vol. 75   page: 958-960   2001.9

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  81. 卵白による血中コレステロール濃度抑制作用のメカニズム

    "小田裕昭,林直紀"

    鶏卵肉情報   Vol. 7/10   page: 74-77   2001.7

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  82. Dietary taurine potentiates polychlorinated biphenyls induced hypercholesterolemia in rats.

    "Mochizuki, H., Oda, H. and Yokogoshi, H."

    Journal of Nutritional Biochemistry   Vol. 12   page: 109-115   2001.1

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  83. Taurine inhibits development of atherosclerotic lesions in apolipoprotein E-deficient mice.

    "Kondo, Y., Toda, Y., Kitajima, H., Oda, H., Nagate, T., Kameo, K. and Murakami, S."

    Clinical and Experimental Pharmacology and Physiology   Vol. 28   page: 809-815   2001.1

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  84. Apolipoprotein A-I gene expression is upregulated by polychlorinated biphenyls in rat liver

    "Oda, H., Suzuki, Y., Wakayama, M. and Yoshida, A."

    Journal of Nutritional Biochemistry   Vol. 11   page: 568-573   2000.11

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  85. In vivo gene electroporation confers nutritionally-regulated foreign gene expression in the liver.

    "Muramatsu, T., Ito, N., Tamaoki, N., Oda, H. and Park, H-M."

    International Journal of Molecular Medicine   Vol. 7   page: 61-66   2000.7

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  86. Dietary taurine alters ascorbic acid metabolism in rats fed diets containing polychlorinated biphenyls

    "Mochizuki, H., Oda, H. and Yokogoshi, H."

    Journal of Nutrition   Vol. 130   page: 873-876   2000.1

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  87. Amplified effect of dietary taurine on the induction of cytochrome P-450 and on the urinary excretion of ascorbic acid in rats fed on phenobarbital-containing diets Reviewed

    Mochizuki, H., Takido, J., Oda, H. and Yokogoshi, H.

    Bioscience, Biotechnology, and Biochemistry   Vol. 64   page: 405-407   2000.1

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  88. Glucocorticoid-dependent induction of HMG-CoA reductase and malic enzyme gene expression by polychlorinated biphenyls in rat hepatocytes

    "Oda, H., Suzuki, Y., Shibata, T. and Yoshida, A."

    Journal of Nutritinal Biochemistry   Vol. 10   page: 644-653   1999.11

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  89. Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet

    "Yokogoshi, H., Mochizuki, H., Nanami, K., Hida, Y., Miyachi, F. and Oda, H."

    Journal of Nutrition   Vol. 129   page: 1705-1712   1999.9

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  90. 肝臓特異的遺伝子発現の調節機構とその制御

    小田裕昭

    組織培養研究   Vol. 18   page: 203-219   1999.9

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  91. プロラクチン分泌を促進する脳内ペプチドの発見

    "小田裕昭,垣沼淳司"

    蛋白質 核酸 酵素   Vol. 44   page: 881-886   1999.6

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  92. Improving effect of dietary taurine on marked hypercholesterolemia induced by a high-cholesterol diet in streptozotocin-induced diabetic rats

    Mochizuki, H., Takido, J., Oda, H. and Yokogoshi, H.

    "Bioscience, Biotechnology, and Biochemistry"   Vol. 63   page: 1984-1987   1999.1

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  93. Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene Reviewed

    "Okazaki, M., Ito, S., Kawakita, K., Takeshita, S., Kawai, S., Makishima, F., Oda, H. and Kakinuma, A."

    Genomics   Vol. 60   page: 87-95   1999.1

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  94. Phosphorylation/dephosphorylation steps are crucial for the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital

    "Kawamura, A., Yoshida, Y., Kimura, N., Oda, H. and Kakinuma, A."

    Biochemical and Biophysical Research Communications   Vol. 264   page: 530-536   1999.1

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  95. 炭水化物による遺伝子発現制御I.ホスホエノールピルビン酸カルボキシキナーゼ遺伝子について

    小田裕昭

    日本農芸化学会誌   Vol. 72   page: 1059-1062   1998.9

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  96. 栄養素はどうやって遺伝子発現を制御するか

    小田裕昭

    日本農芸化学会誌   Vol. 72   page: 1057-1058   1998.9

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  97. Dietary taurine increases serum HDL-cholesterol concentrations in rats.

    "Mochizuki, H., Oda, H. and Yokogoshi, H.,"

    "Bioscience, Biotechnology, and Biochemistry"   Vol. 62   page: 578-579   1998.1

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  98. Alteration of expression of liver-enriched transcription factors in the transition between growth a differentiation of primary cultured rat hepatocytes.

    "Mizuguchi, T., Mitaka, T., Hirata, K., Oda, H. and Mochizuki, Y.,"

    Journal of Cellular Physiology   Vol. 174   page: 273-284   1998.1

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  99. Extracellular matrix regulates hepatocyte gene expression and differentiation.

    "Oda, H."

    Connective Tissue   Vol. 30   page: 225-232   1998.1

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  100. Amplified effect of taurine on PCB-induced hypercholesterolemia in rats

    "Mochizuki, H., Oda, H. and Yokogoshi, H."

    Advance in Experimental Medicine and Biology   Vol. 442   page: 285-290   1998.1

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  101. 肝臓”生体化学コンビナート”の設計図

    小田裕昭

    必須アミノ酸研究   Vol. 153   page: 9-12   1998.1

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  102. 新しい肝臓特異的転写因子HNF-6

    小田裕昭

    生化学   Vol. 70   page: 434-436   1998.1

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  103. Alteration of expression of liver-enriched transcription factors in the transition between growth and differentiation of primary cultured rat hepatocytes Reviewed

    Journal of Cellular Physiology   Vol. 174   page: 273-284   1998

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  104. Extracellular matrix regulates hepatocyte gene expression and differentiation Invited Reviewed

    Connective Tissue   Vol. 30   page: 225-232   1998

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  105. Dietary taurine increases HDL-cholesterol concentrations in rats Reviewed

    Bioscience, Biotechnology, and Biochemistry   Vol. 62   page: 578-579   1998

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  106. 新しい肝臓特異的転写因子HNF-6

    生化学   Vol. 70 ( 6 ) page: 434-436   1998

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  107. Amplified effect of taurine on PCB-induced hypercholesterolemia in rats Reviewed

    Adv. Exp. Med. Biol.   Vol. 442   page: 285-290   1998

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  108. マトリゲルによる肝細胞の分化維持

    小田裕昭

    組織培養工学   Vol. 23   page: 229-231   1997.5

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  109. High responsiveness to thyroid hormone of adult rat primary hepatocytes cultured on EHS-gel.

    "Oda, H., Nozawa, K., Miyachi, F., Shimizu, A., Iwasaki, Y. and Kakinuma, A.,"

    "Bioscience, Biotechnology, and Biochemistry"   Vol. 61   page: 1590-1592   1997.1

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  110. 食環境因子によるコレステロール代謝の制御

    小田裕昭

    バイオサイエンスとインダストリー   Vol. 55   page: 198-201   1997.1

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  111. Biochemical and functional characterization of DNA complexs capable of targeting genes to hepatocytes via the asialoglycoprotein receptor

    Journal of Biological Chemistry   Vol. 272 ( 11 ) page: 7398-7407   1997

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  112. *HNF-6 is expressed in endoderm devivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors Reviewed

    Developmental Biology   Vol. 192   page: 247-257   1997

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  113. マトリゲルによる肝細胞の分化維持

    組織培養工学   Vol. 23   page: 229-231   1997

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  114. 食環境因子によるコレステロール代謝の制御

    バイオサイエンスとインダストリー   Vol. 55   page: 198-201   1997

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  115. High responsiveness to thyroid hormone of adult rat primary hepatocytes cultured on EHS-gel

    Bioscience, Biotechnology, and Biochemistry   Vol. 61   page: 1590-1592   1997

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  116. Insulin suppresses the iuction of CYP2B1 a CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes.

    "Yoshida, Y., Kimura, N. Oda, H. and Kakinuma, A.,"

    Biochemical and Biophysiccal Research Communications   Vol. 229   page: 182-188   1996.1

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  117. Oxidative stress response in iron-iuced renal nephrotoxicity: Enhanced expression of heat shock protein 90.

    "Fukuda, A., Osawa, T., Oda, H., Tanaka, T., Toyokuni, S. and Uchida, K.,"

    Biochemical and Biophysiccal Research Communications   Vol. 219   page: 76-81   1996.1

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  118. Oxidative stress response in iron-iuced renal carcinogenesis: Acute nephrotoxicity mediates the enhanced expression of glutathione S-transferase Yp isozyme.

    "Fukuda, A., Osawa, T., Oda, H., Toyokuni, S., Satoh, K. and Uchida, K.,"

    Archives Biochemistry and Biophysics   Vol. 329   page: 39-46   1996.1

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  119. Antihypercholesterolemic action of taurine on streptozotocin-diabetic rats or on rats fed a high cholesterol diet.

    "Nanami, K., Oda, H. and Yokogoshi, H.,"

    Advance of Experimental Medical Biology   Vol. 403   page: 561-568   1996.1

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  120. Antihypercholesterolemic action of taurine on streptozotocin-diabetic rats or on rats fed a high cholesterol diet Reviewed

    Adv. Exp. Med. Biol.   Vol. 403   page: 561-568   1996

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  121. *Laminin-rich extracellular matrix maintains high level of hepatocyte nuclear factor 4 in rat hepatocyte culture. Reviewed

    "Oda, H., Nozawa, K., Hitomi, Y. and Kakinuma, A.,"

    Biochemical and Biophysiccal Research Communications   Vol. 212   page: 800-805   1995.1

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  122. 食環境因子によるリポタンパク質代謝の変動機構に関する研究

    小田裕昭

    日本栄養・食糧学会誌   Vol. 48   page: 357-364   1995.1

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  123. Effect of feeding xenobiotics on serum high density lipoprotein and apolipoprotein A-I in rats Reviewed

    Bioscience, Biotechnology, and Biochemistry   Vol. 58 ( 9 ) page: 1646   1994

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  124. Induction of HMG-CoA reductase and malic enzyme gene expression by polychlorinated biphenyls in rat hepatocytes cultured on EHS-gel, not on type I collagen Reviewed

    Animal Cell Technology   Vol. 6   page: 487   1994

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  125. Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins : Markers for atherosclerosis Reviewed

    Biochemistry   Vol. 33 ( 41 ) page: 12487   1994

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  126. Induction of cytochrome P-450s and expression of liver-specific genes in rat primary hepatocytes cultured on different extracellular matrices Reviewed

    Bioscience, Biotechnology, and Biochemistry   Vol. 58 ( 8 ) page: 1514   1994

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  127. タンパク質・アミノ酸栄養とコレステロール代謝関連遺伝子の発現 Invited

    必須アミノ酸研究   Vol. 138   page: 18   1994

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  128. Cholesterol-rich very low density lipoproteins and fatty liver in rats fed polychlorinated biphenyls Reviewed

    Bioscience, Biotechnology, and Biochemistry   Vol. 58 ( 12 ) page: 2152   1994

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  129. Liver-specific induction of NADPH-generating enzymes by polychlorinated biphenyls in rats

    Bioscience, Biotechnology, and Biochemistry   Vol. 57 ( 7 ) page: 1134-1136   1993

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  130. Ascorbic acid deficiency reduces the level of mRNA for cytochrome P-450 on the induction by polychlorinated biphenyls

    Journal of Nutritional Science and Vitaminology   Vol. 39 ( 4 ) page: 289-302   1993

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  131. Multiple regulation of gluconeogenesis by hormones -Transcriptional regulation of phosphoenolpyrvate carboxykinase gene-

    Chemistry and Biology   Vol. 31 ( 8 ) page: 490-492   1993

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  132. Short-term effects of ethanol intoxication on ascorbic acid and lipid metabolism and drug-metabolizing enzymes in liver of rats

    Bioscience, Biotechnology, and Biochemistry   Vol. 56 ( 4 ) page: 576-579   1992

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  133. Effect of supplementation of methionine to a soyprotein diet on serum cholesterol and liver apolipoprotein A-I mRNA in rats

    Nutritional Science of Soy Protein   Vol. 12   page: 1   1991

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  134. Alteration of serum lipoprotein metabolism by polychlorinated biphenyls and methionine in rats fed a soy protein diet

    Journal of Nutrition   Vol. 121   page: 7   1991

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  135. Effects of polychlorinated biphenyls on cholesterol and ascorbic acid metabolism in primary cultured rat hepatocytes

    Biochemical Pharmacology   Vol. 41   page: 8   1991

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  136. Thyroid hormone induces fibronectin gene expression in cultured rat hepatocytes

    Environmental Medicine     page: 34   1990

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  137. Characteristic effect of soy and rice protein on cholesterol metabolism in rats Reviewed

    Karger     page: 1-10   1990

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    Language:English   Publishing type:Research paper (scientific journal)  

  138. Nutritional specificity of soy protein isolate for serum lipoprotein metabolism in rats

    Nutritional Science of Soy Protein   Vol. 11   page: 1   1990

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    Language:English  

  139. Hyperlipoproteinemia in rats fed polychlorinated biphenyls

    Journal of Nutritional Science and Vitaminology   Vol. 36   page: 2   1990

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    Language:English  

  140. Effect of dietary methionine and polychlorinated biphenyls on cholesterol metabolism in rats fed a diet containing soy protein isolate

    Journal of Nutritional Science and Vitaminology   Vol. 35   page: 4   1989

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    Language:English  

  141. Long-term effects of dietary polychlorinated biphenyls and high level of vitamin E on ascorbic acid and lipid metabolism in rats

    Journal of Nutrition   Vol. 117   page: 7   1987

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    Language:English  

  142. Effects of dietary methionine, cystine and potassium sulfate on serum cholesterol and urinary ascorbic acid in rats fed PCB

    Journal of Nutrition   Vol. 116   page: 9   1986

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    Language:English  

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Books 17

  1. Nutrition & Health

    ( Role: Joint author)

    2024.2  ( ISBN:978-4-320-06198-9

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    Total pages:267   Language:Japanese

  2. 時間栄養学-時計遺伝子と食事のリズム-

    香川靖雄、柴田重信、小田裕昭、加藤秀夫、堀江修一、榛葉繁紀( Role: Joint author)

    女子栄養大学出版部  2009.2 

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    Language:Japanese

  3. 生化学・基礎栄養学 第3版

    ( Role: Joint author)

    朝倉書店  2022.9 

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    Language:Japanese

  4. 生化学・基礎栄養学 第2版

    小田裕昭、池田彩子、石原健吾、西村直道、山中なつみ、松尾道憲、山田貴史( Role: Joint author)

    朝倉書店  2017.9 

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    Language:Japanese

  5. 生化学・基礎栄養学

    小田裕昭、池田彩子、石原健吾、竹中康之、西村直道、山中なつみ( Role: Joint author)

    朝倉書店  2013.2 

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    Language:Japanese

  6. 健康栄養学 −健康科学としての栄養生理化学− 第2版

    小田裕昭、加藤久典、関 泰一郎 編( Role: Joint author)

    共立出版  2014.10 

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    Language:Japanese

  7. 健康栄養学 −健康科学としての栄養生理化学−

    小田裕昭、加藤久典、関 泰一郎 編( Role: Joint author)

    共立出版  2005 

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    Language:Japanese

  8. 糖質・甘味のおいしさ評価と健康・調理・加工

    小田裕昭、孫淑敏( Role: Joint author)

    NTS  2022.1 

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    Language:Japanese

  9. 次世代がん治療

    小田裕昭( Role: Joint author)

    NTS  2017.6 

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    Language:Japanese Book type:Scholarly book

  10. ニュートリゲノミクスを基盤としたバイオマーカーの開発 -未病診断とテーラーメイド食品開発に向けて-

    小田裕昭( Role: Joint author)

    シーエムシー出版  2013.9 

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    Language:Japanese Book type:Scholarly book

  11. Toxicity and Drug Testing

    Hashizume, T. and Oda, H.( Role: Joint author)

    InTech  2012.2  ( ISBN:979-953-307-310-0

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    Language:English Book type:Scholarly book

  12. 栄養・食糧学 データハンドブック

    日本栄養・食糧学会 編( Role: Joint author)

    同文書院  2006 

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    Language:Japanese

  13. 代謝栄養学

    横越英彦 編( Role: Joint author)

    同文書院  2005 

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    Language:Japanese

  14. 新版 家政学事典

    日本家政学会 編( Role: Joint author)

    朝倉書店  2004 

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    Language:Japanese

  15. 分子栄養学 −栄養素と生活習慣病の分子生物学−非栄養素の分子生物学

    垣沼淳司 編( Role: Joint author)

    光生館  2002 

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    Language:Japanese

  16. "細胞の分化,再生,形態形成"肝細胞の形態による肝細胞分化維持機構

    "小田裕昭( 編:藤原研司,石井裕正,佐藤信紘,荒川泰行,井廻道夫編)"( Role: Sole author)

    自然科学社  1999 

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    Language:Japanese

  17. 分子栄養学概論

    小田裕昭( 編:田中武彦・野口忠・武藤泰敏編)( Role: Joint author)

    建帛社  1996 

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    Language:Japanese

    生体異物と遺伝子発現

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Presentations 5

  1. 時間栄養学

    小田裕昭

    ILSI Japan 30周年記念 国際会議 第6回「栄養とエイジング」 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  2. 時間栄養学と脂質代謝異常

    小田裕昭

    財団法人 若さの栄養学協会 第41回栄養学連続講義 -最新の知見と栄養学ケア- 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:大阪   Country:Japan  

  3. Liver clock and chrono-nutritional regulation of cholesterol metabolism

    Oda, H. and Yamajuku, D

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    Event date: 2010.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  4. Functions of sulfur-containing amino acids in lipid metabolism International conference

    The Fifth Workshop on the Assesment of Adequate Intake of Dietary Amino Acids 

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    Event date: 2005.10

    Language:English   Presentation type:Oral presentation (invited, special)  

  5. Control of hepatocyte differentiation by manipulation of cell environments. International conference

    The 4th International Conference on Intelligent Materials. 

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    Event date: 1998.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

    Chiba Japan

KAKENHI (Grants-in-Aid for Scientific Research) 16

  1. Establishment of a new paradigm for sucrose-fructose nutrition

    Grant number:21K18295  2021.7 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Pioneering)

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    Authorship:Principal investigator 

    Grant amount:\26000000 ( Direct Cost: \20000000 、 Indirect Cost:\6000000 )

  2. Coordinated synchronization of inter-organ crosstalk of biological clock for health constitution

    Grant number:20H02930  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Oda Hiroaki

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    Authorship:Principal investigator 

    Grant amount:\18070000 ( Direct Cost: \13900000 、 Indirect Cost:\4170000 )

    In this study, we have examined how the liver clock and the clocks of other organs are synchronized and regulated, and have examined the crosstalk between these organs. We have shown that insulin is a strong factor in synchronizing the liver clock. Free fatty acids and bile acids were found to be candidates for entrainment factors, as were insulin, for which differences in the phase of the rhythm were observed. The muscle clock was also found to be regulated by the timing of food intake and muscle mass. Misalignment of insulin entrainment caused abnormalities in liver and muscle homeostasis, and feeding timing was found to influence metabolic syndrome and locomotive syndrome via biological clock crosstalk between organs.

  3. Basic research on proper vitamin intake aimed at preventing locomotive syndrome

    Grant number:17H01970  2017.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Ikeda Saiko

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    Authorship:Coinvestigator(s) 

    In this study, the effects of vitamins E, K, and C on bone metabolism were examined using rats. Male Wistar and ODS rats were fed a diet with different contents of RRR-α-tocopherol, phylloquinone, and L-ascorbic acid for a certain period of time. Differences in vitamin E and K intake had little effect on markers of bone mineral density and bone metabolism in rats. On the other hand, bone density and bone metabolism markers fluctuated due to insufficient intake of vitamin C. Therefore, it was suggested that among these vitamins, vitamin C has the greatest effect on bone metabolism.

  4. ロコモティブシンドローム予防を目指した適正なビタミン摂取についての基盤研究

    2017.4 - 2019.3

    科学研究費補助金  基盤研究(B)

    池田彩子

  5. Prevention of life-related diseases through synchronization of tissue clocks by eating timing

    Grant number:16H04922  2016.4 - 2019.3

    Oda Hiroaki

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    Authorship:Principal investigator 

    Grant amount:\17940000 ( Direct Cost: \13800000 、 Indirect Cost:\4140000 )

    Nutrition, exercise and sleep are the key to good health. From the perspective of the biological clock, these three elements are considered to be integrablely controlled, revealing the molecular basis for normalizing metabolism and linking it to health through synchronization of the inter-organ clock network. In this study, I investigated breakfast skipping as an irregular feeding timing that can occur especially in humans. Breakfast skipping just delay the first meal for a few hours after rest, but metabolic abnormalities have been shown to occur in many human studies. In a breakfast skipping animal model fed a high-fat diet, it was revealed that the rhythm of the liver clock and liver lipid metabolism was delayed for several hours, leading to weight gain.

  6. 二枚貝由来新規機能成分の探索と作用機序の解明

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

    望月聡

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    Authorship:Coinvestigator(s) 

  7. Search of bivalve-originated new functional ingredients and elucidation of action mechanism

    Grant number:15K00824  2015.4 - 2018.3

    Mochizuki Satoshi

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    Authorship:Coinvestigator(s) 

    An attempt was made to synthesize an analogue of ceramide phosphoramidate molecular species obtained as an active constituent from a lipid fraction derived from freshwater clam (Corbicula fluminea). Although the synthesis of the ceramide moiety was successful, its phosphorylation reaction was difficult. Therefore, the reaction condition is continuously examined at present.
    We found that protein fraction of freshwater clam extract (FCE) reduced serum level of cholesterol in rats fed a high cholesterol diet. Since the protein fraction of FCE enhanced catabolism of cholesterol as soy protein isolate did, both protein fraction of FCE and soy protein isolate changed cholesterol metabolism by a similar mechanism. In order to investigate the effect of other bivalves on lipid metabolism, we next focused on oyster.

  8. 咀嚼による肝臓・消化器機能の制御と生活習慣病予防に関する分子栄養学

    2015.4 - 2017.3

    科学研究費補助金 

    小田裕昭

  9. 代謝のキー調節因子としての摂食タイミングの分子作用機序と中枢-末梢時計の同調機構

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  10. 脂質代謝を中心とした二枚貝の生理機能に関する研究

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(C)

    望月聡

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    Authorship:Coinvestigator(s) 

  11. 時間栄養学による脂質代謝異常の改善と摂食タイミングによる肝臓時計同調機構の解析

    2009 - 2011.3

    科学研究費補助金  挑戦的萌芽研究,課題番号:21658052

    小田 裕昭

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    Authorship:Principal investigator 

  12. 次世代型生体調節因子としてのアミノ酸の新規機能性の探索と有効性の検証

    2008.4 - 2010.3

    科学研究費補助金  基盤研究(A)

    門脇基二

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    Authorship:Coinvestigator(s) 

  13. 脂質代謝改善モデュレーターとしてのタンパク質・アミノ酸の分子作用機構

    2003 - 2004

    科学研究費補助金  基盤研究(C),課題番号:15580104

    小田 裕昭

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    Authorship:Principal investigator 

  14. 肝臓特異的転写因子ネットワークの肝細胞分化の決定機構

    1998.1 - 2020.12

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

    科研費

  15. 生理活性タンパク質の消化管吸収に及ぼす年齢、病態、栄養、薬物共存の影響

    1996.1 - 1998.12

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

    科研費

  16. 細胞内リドックス(酸化還元状態)による遺伝子発現の調節とその栄養制御 -HIV-1の転写制御によるAIDS発症予防に関する基礎的研究-

    1994.1 - 1996.12

    科学研究費補助金  一般研究(C)

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    Authorship:Principal investigator 

    科研費

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Teaching Experience (On-campus) 14

  1. 栄養科学

    2014

  2. 栄養科学

    2012

  3. 基礎セミナーA

    2014

  4. 細胞生物学4

    2014

  5. 基礎セミナーA

    2013

  6. 細胞生物学4

    2013

  7. 細胞生物学4

    2012

  8. 基礎セミナー

    2012

     詳細を見る

    生命科学と倫理と法

  9. 食と農の科学

    2011

  10. 栄養科学

    2021

  11. 分子細胞生物学4

    2021

  12. 基礎セミナー

    2021

  13. 栄養生化学特論

    2021

  14. Science of Food and Agriculture

    2011

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Teaching Experience (Off-campus) 26

  1. 正常と異常の生命科学

    2013.4 - 2014.3 The University of Tokyo)

  2. 食品生物科学特論

    2013.4 - 2014.3 Kyoto University)

  3. システム生物学特論第一

    2011.4 - 2012.3 Kyushu University)

  4. 生物生産科学特別講義III

    2009.4 - 2010.3 Utsunomiya University)

  5. 生化学実験

    2021.10 Nagoya Bunri University)

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    Level:Undergraduate (specialized) 

  6. 栄養学

    2020.4 Sugiyama Jogakuen University)

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    Level:Undergraduate (liberal arts) 

  7. 食品栄養科学特別講義A

    2019.4 - 2020.3 Chubu University)

  8. 生化学

    2018.10 - 2019.3 Osaka City University)

  9. 食品栄養科学特別講義A

    2017.4 - 2018.3 Chubu University)

  10. 食品栄養科学特別講義A

    2015.4 - 2016.3 Chubu University)

  11. 栄養学

    2014.4 - 2015.3 Sugiyama Jogakuen University)

  12. 食品栄養科学特別講義A

    2013.4 - 2014.3 Chubu University)

  13. 栄養学

    2013.4 - 2014.3 Sugiyama Jogakuen University)

  14. 栄養学

    2012.4 - 2013.3 Sugiyama Jogakuen University)

  15. 食品栄養科学特別講義A

    2011.4 - 2012.3 Chubu University)

  16. 2009.4 - 2010.3 Sugiyama Jogakuen University)

  17. 栄養学

    2008.4 - 2009.3 Sugiyama Jogakuen University)

  18. 栄養学

    2007.4 - 2008.3 Sugiyama Jogakuen University)

  19. 栄養学

    2006.4 - 2007.3 Sugiyama Jogakuen University)

  20. 栄養学

    2005.4 - 2006.3 Sugiyama Jogakuen University)

  21. 解剖生理学実験

    1998.4 - 1999.3 Junior College Division,Tokai Gakuen University)

  22. 解剖生理学実験

    1997.4 - 1998.3 Junior College Division,Tokai Gakuen University)

  23. 解剖生理学実験

    1996.4 - 1997.3 Junior College Division,Tokai Gakuen University)

  24. 家庭科研究A

    1995.4 - 1996.3 Aichi University of Education)

  25. 家庭科研究A

    1993.4 - 1994.3 Aichi University of Education)

  26. 栄養学I

    1988.4 - 1989.3 Aichi University of Education)

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Social Contribution 4

  1. サイエンスカフェ 名古屋市科学館、日本農芸化学会

    2012.11

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    サイエンスカフェ「体内時計の乱れと食事とメタボ」

  2. 時間栄養学 -食べるタイミングとメタボ予防-

    Role(s):Lecturer

    公益財団法人 ひと・健康・未来研究財団  2019.9

  3. 名城大学農学部公開講座

    2008.12

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    講演会「食べたものはどこへ行ってしまうのか~食べ物の生体内の旅路~」

  4. 名古屋大学教育学部附属高等学校SSH

    Role(s):Lecturer

    名古屋大学付属高校  2008.7 - 2020.7

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    Audience: High school students

    Type:Visiting lecture