Updated on 2025/03/21

写真a

 
MATSUSHIMA, Miyoko
 
Organization
Graduate School of Medicine Associate Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Associate Professor
Contact information
メールアドレス

Degree 1

  1. 博士(医療技術学) ( 2007.3   名古屋大学 ) 

Research Areas 2

  1. Life Science / Immunology

  2. Others / Others  / Pathological Examination Studies

Research History 2

  1. Nagoya University

    2010.4

  2. 名古屋大学大学院工学研究科 研究員

    2007.4 - 2007.11

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    Country:Japan

Education 3

  1. Nagoya University   Graduate School, Division of Medical Sciences   Program in Radiological and Medical Laboratory Sciences

    2004.4 - 2007.3

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    Country: Japan

  2. Nagoya University   Graduate School, Division of Medical Sciences   Program in Radiological and Medical Laboratory Sciences

    2002.4 - 2004.3

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    Country: Japan

  3. Nagoya University   Faculty of Medicine

    1998.4 - 2002.3

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    Country: Japan

Professional Memberships 6

  1. Japanese Sciety of Immunology

  2. Japanese Society of Allergology

  3. Japanese Society of Occupational Allergy

  4. The Pharmaceutical Society of Japan

  5. 日本食品免疫学会

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Papers 64

  1. Observation of Fine Lung Structure by Ultrahigh-Resolution Optical Coherence Tomography Using 800, 1060, and 1300nm Supercontinua Reviewed

    Ishida S, Nishizawa N, Kitatsuji M, Ohshima H, Hasegawa Y, Matsushima M, Kawabe T.

    Jpn. J. Appl. Phys   Vol. 51   page: 047001   2012.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  2. Attenuation of TGF-beta-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-1. Reviewed

    Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T.

    Am J Respir Cell Mol Biol   Vol. 44 ( 5 ) page: 614-620   2011.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed ID: 21216973

  3. Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants Reviewed

    Takahashi Y, Tamakoshi K, Matsushima M, Kawabe T.

    Early Hum. Dev   Vol. 87 ( 3 ) page: 151-157   2011.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed ID: 21220191

    DOI: 10.1016/j.earlhumdev.2010.11.012

  4. Characteristics of an optimized catheter-type thermal flow sensor for measuring reciprocating airflows in bronchial pathways Reviewed

    Shikida M, Yokota T, Kawabe , Funaki T, Matsushima M, Iwai S, Matsunaga N, Sato K

    Micromech. Microen   Vol. 20 ( 12 ) page: 1-11   2010.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    We optimized a catheter-type thermal flow sensor to measure the reciprocating airflows in
    bronchial pathways. The electrical wiring in the outer tube was extracted to keep the symmetry
    of the temperature distribution on the heaters. First, a flexible sensor was fabricated on
    polyimide film with photolithography, and then the enameled wires were bonded to the contact
    pads on the film with anisotropic conductive film. The film sensor was finally assembled with
    a catheter configuration that had a diameter of 1.8 mm by applying a heat shrinkable tube. We
    experimentally confirmed that the sensor outputs under both forward and reverse flow
    conditions had the same output characteristics when a design with symmetrical heating
    elements was applied. The sensor outputs we obtained at a reciprocating flow frequency
    ranging from 1 to 3 Hz almost coincided, and they also fit that obtained under unidirectional
    airflow conditions. Finally, the aspirated- and inspired-air characteristics in the air passages of
    small laboratory animals (rats and mice) were measured. Due to our development of a flexible
    method of electrical wiring, we could try a new approach to intubation measurements in which
    the sensor was inserted into the air passage from the mouth with a fiberscope, and we
    confirmed that the sensor we developed was able to directly measure the breathing
    characteristics in air passages. Implanted measurements were also attempted in this study.
    (Some figures in this article are in colour only in the electronic version)

    DOI: 10.1088/0960-1317/20/12/125030

  5. Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues Reviewed

    Hirayama T, Kawabe T, Matsushima M, Nishimura Y, Kobe Y, Ota Y, Baba K, Takagi K

    Peptides   Vol. 31 ( 11 ) page: 2109-2113   2010.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed ID: 20691233

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Books 1

  1. 覚せい剤依存と麻薬依存

    北市清幸, 森下友喜, 土井悠子, 上山 純, 松島充代子, 巽 康彰, 高木健次, 柴田英治, 高木健三, 長谷川高明.( Role: Sole author)

    東北大学出版会  2004 

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    Language:Japanese

Presentations 282

  1. Quercetin-induced cytoprotective action by modification of cell membrane International conference

    Matsushima M., Nose H., Kusatsugu Y., Tanaka K., Takekoshi M., Tsubosaki Y., Inoue G., Iwaki K., Hayashi Y., Yamashita T., Kawabe T.

    IUIS2019 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  2. Effects of neonicotinoid and organophosphorus insecticides on macrophage functions. International conference

    SASOU Kanako, MATSUSHIMA Miyoko, OGASAWARA Nanako, OHDACHI Tomoko, ATSUMI Kazuko, TANAKA Kyohka, SUGIYAMA Tomoshi, UEYAMA Jun, HASHIMOTO Naozumi, KAWABE Tsutomu.

    18th World Congress of Basic and Clinical Pharmacology 

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    Event date: 2018.7

    Language:English   Presentation type:Poster presentation  

  3. Effects of diazinon on mast cell activation International conference

    TANAKA Kyohka, MATSUSHIMA Miyoko, ATSUMI Kazuko, SASOU Kanako, SUGIYAMA Tomoshi, OHDACHI Tomoko, UEYAMA Jun, HASHIMOTO Naozumi, KAWABE Tsutomu

    18th World Congress of Basic and Clinical Pharmacology 

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    Event date: 2018.7

    Language:English   Presentation type:Poster presentation  

  4. Involvement of localization changes of caveolin-1 in Nrf2 activation induced by quercetin International conference

    Matsushima Miyoko, Kusatsugu Yuto, Ochi Haruka, Oyabu Savaka, Atsumi Kazuko, Ogasawara Nanako, Kawabe Tsutomu

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    Event date: 2017.3

    Language:Japanese   Presentation type:Poster presentation  

  5. アトピー性皮膚炎モデルNC/NgaマウスにおけるB細胞共受容体CD72のリンパ球における機能の検討

    安藤 梓乃, 松島 充代子,林 風月,小林 純,佐藤 光夫, 川部 勤

    第6回日本アレルギー学会東海地方会  2025.3.9 

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    Event date: 2025.3

    Language:Japanese   Presentation type:Oral presentation (general)  

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Research Project for Joint Research, Competitive Funding, etc. 7

  1. 家庭内肺健康度評価を可能にする呼吸モニタリングシステムの開発

    Grant number:JPMJTR23R1  2023.11 - 2026.3

    研究成果最適展開支援プログラム 産学共同(育成型) 

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    Authorship:Principal investigator  Grant type:Competitive

  2. 3型炎症を標的としたフラボノイドによる新規生体防御誘導機構の解明

    2023.11 - 2026.11

    第10回(令和5年度)研究助成 

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    Grant type:Competitive

    Grant amount:\1500000

  3. 気管挿管時の換気物理量解析による心機能評価可能な呼吸・循環監視装置の開発

    2021.11 - 2022.11

    公益財団法人鈴木謙三記念医科学応用研究財団 

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    Authorship:Principal investigator 

    Grant amount:\1000000

  4. 環境物質に対するフラボノイドの細胞保護効果とその機序

    2014.4 - 2015.3

    那古野医学振興会  

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    Grant type:Competitive

  5. フラボノイドによる抗アレルギー活性の新規機序の解明

    2010.4 - 2011.3

    那古野医学振興会  

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. フラボノイドの作用機序から探る細胞保護作用の発動機構の解明

    2013.4 - 2015.3

    科学研究費補助金  若手研究(B)

    松島充代子

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    Authorship:Principal investigator 

  2. フラボノイドが誘導するHO‐1を介した急性肺障害の新規治療法開発の基礎的検討

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(C)

    川部 勤

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    Authorship:Coinvestigator(s) 

  3. ストレスセンシング機構を標的としたフラボノイドの細胞保護作用発動機構の解明

    Grant number:20K11529  2020.4 - 2023.3

    科学研究費補助金  

    松島 充代子

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    フラボノイドは天然の機能性成分で、多彩な細胞保護効果を示す。本研究ではフラボノイドは共通した起点となる細胞膜でセンシングされ、普遍的な生体防御機構を誘導すると考え、細胞がフラボノイドを感知するストレスセンシング機構を探索・同定し、フラボノイドの多彩な細胞保護効果の発揮の出発点となる分子機構を解明する。

  4. マクロファージを主軸とする自然免疫応答から探求する傷害組織の修復機構の解明

    Grant number:20K07824  2020.4 - 2023.3

    科学研究費補助金  

    川部 勤

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\600000 ( Direct Cost: \600000 )

    マクロファージの組織の修復機転、特に死細胞を貪食処理するエフェロサイトーシスに自然免疫の環境がどのような意義を持つのか、マクロファージの他、修復機構に重要な働きをすると考えられる、傷害部位の組織構成細胞や自然リンパ球がどのように協働しているかを解明する。本研究により解明される有効な修復機構を誘導することで、組織傷害に対してより完全な修復・治癒機転の招来をもたらす。

  5. Analysis of adverse effects of acetylcholinergic pesticides focused on the induction of host defense reaction and immune disruption

    Grant number:17K00547  2017.4 - 2020.3

    Kawabe Tsutomu

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\600000 ( Direct Cost: \600000 )

    In this study, we investigated the effects of acetylcholinergic pestcides, particularly neonicotinoid pesticides, on the induction of host defense reaction and functions of macrophages and T cells. We showed that acetamiprid modulated the function of alveolar macrophages. Briefly, acetamiprid inhibited the levels of inflammatory cytokine mRNA expression and phagocytosis induced by imiquimod, a ligand of TLR7, in alveolar macrophages, while acetamiprid exhibited little effect on the induction of host defense reaction including HO-1 expression and autophagy. Moreover, acetamiprid did not affect T-cell activation. These results suggested the possibility that acetamiprid could influence the host defense reaction in the lung.

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Teaching Experience (On-campus) 20

  1. 医療安全管理学

    2024

  2. 生物学基礎II

    2024

  3. 生物学実験

    2024

  4. Advanced Topics of Cellular and Genetic Sciences

    2021

  5. Immunology

    2021

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Teaching Experience (Off-campus) 1

  1. 解剖生理学実験

    2015.4 - 2024.3 Tokai Gakuen University)

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    Level:Undergraduate (specialized) 

 

Social Contribution 3

  1. 第30回アレルギー週間市民公開講座

    Role(s):Presenter, Planner, Organizing member

    日本アレルギー協会東海支部  第30回アレルギー週間市民公開講座  2024.2

  2. 第29回アレルギー週間市民公開講座

    Role(s):Organizing member

    日本アレルギー協会東海支部  第29回アレルギー週間市民公開講座  2023.2

  3. 第28回アレルギー週間市民公開講座

    Role(s):Presenter, Planner, Organizing member

    日本アレルギー協会東海支部  2022.2

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    Audience: General

    Type:Lecture

Academic Activities 1

  1. 第5回日本アレルギー学会東海地方会

    Role(s):Planning, management, etc.

    日本アレルギー学会東海支部  2024.3

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    Type:Academic society, research group, etc.