Faculty Profiles - KASHIDA, Hiromu

Papers - KASHIDA, Hiromu

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Analysis of Coherent Heteroclustering of Different Dyes by Use of Threoninol-Nucleotides for Comparison with the Molecular Exciton Theory Reviewed

T. Fujii, H. Kashida, H. Asanuma

Chem. Eur. J. Vol. 15 page： 10092-10102 2009

Postsynthetic modification of DNA via threoninol on a solid support by means of allylic protection. Reviewed

H. Asanuma, Y. Hara, A. Noguchi, K. Sano, H. Kashida

Tetrahedron Lett. Vol. 49 page： 5144-5146 2008.7

Threoninol as a Scaffold of Dyes (Threoninol-nucleotide) and Their Stable Interstrand Clustering in Duplexes. Reviewed

H. Kashida, T. Fujii, H. Asanuma

Org. Biomol. Chem. Vol. 6 page： 2892-2899 2008.6

Language：English Publishing type：Research paper (scientific journal)

Functional molecules such as dyes (Methyl Red, azobenzene, and Naphthyl Red) were tethered on D-threoninol as base surrogates (threoninol-nucleotide), which were consecutively incorporated at the center of natural oligodeoxyribonucleoticles (ODNs). Hybridization of two ODNs involving threoninol-nucleotides allowed interstrand clustering of the dyes on D-threoninol and greatly stabilized the duplex. Clustering of Methyl Reds induced both hypsochromicity and narrowing of the band, demonstrating that Methyl Reds were axially stacked relative to each other (H-aggregation). Alternate hetero dye clusters could also be prepared only by hybridization of two ODNs with different threoninol-nucleotides, such as Methyl Red-azobenzene and Methyl Red-Naphthyl Red combinations. Thus, D-threoninol can be a versatile scaffold for introducing functional molecules into DNA for their ordered clustering.

Preparation of coherent hetero clusters with threoninol scaffold

T. Fujii, H. Kashida, H. Asanuma

Nucleic Acids Symp. Ser. Vol. 52 page： 699-700 2008

Incorporation of cationic dyes into DNA for distinct stabilization of duplex

H. Kashida, H. Itoh, T. Fujii, H. Asanuma.

Nucleic Acids Symp. Ser. Vol. 52 page： 701-702 2008

Detection of genetic polymorphisms with high sensitivityby DNA–perylene conjugate Reviewed

H. Kashida, T. Takatsu, H. Asanuma

Tetrahedron Lett. Vol. 48 page： 6759-6762 2007.7

2',6'-Dimethylazobenzene as an efficient and thermo-stable photo-regulator for the photoregulation of DNA hybridization. Reviewed

H. Nishioka, X. G. Liang, H. Kashida, H. Asanuma

Chem. Commun. page： 4354-4356 2007

Development of high-sensitive DNA probe by using perylene.

H. Kashida, T. Takatsu, H. Asanuma

Nucleic Acids Symp. Ser. Vol. 51 page： 279-280 2007

Preparation of "comb-type" hetero aggregates by DNA-dye conjugation.

T. Fujii, H. Kashida, H. Asanuma

Nucleic Acids Symp. Ser. Vol. 51 page： 277-278 2007

Construction of novel dye aggregates based on "comb-type" sequence.

H. Kashida, T. Fujii, H. Asanuma

Nucleic Acids Symp. Ser. Vol. 51 page： 11-12 2007

Exciplex formation between pyrene and N,N-dimethylaniline in DNA for the detection of one-base deletion Reviewed

H. Kashida, M. Komiyama, H. Asanuma

Chem. Lett. Vol. 35 ( 8 ) page： 934-035 2006.8

Covalent incorporation of methyl red dyes into double-stranded DNA for their ordered clustering Reviewed

H. Kashida, M. Tanaka, S. Baba, T. Sakamoto, G. Kawai, H. Asanuma, M. Komiyama

Chem. --Eur. J. Vol. 12 ( 3 ) page： 777-784 2006.1

Insertion of two pyrene moieties into oligodeoxyribonucleotides for the efficient detection of deletion polymorphisms Reviewed

H. Kashida, H. Asanuma, M. Komiyama

Chem. Commun. ( 26 ) page： 2768-2770 2006.1

Language：English Publishing type：Research paper (scientific journal)

For the detection of deletion polymorphisms, two pyrene moieties are tethered to oligodeoxyribonucleotide (ODN) on both sides of the intervening base. When this probe ODN was hybridized with wild type ODN, both pyrenes intercalated between base pairs and only monomer emission was observed. In contrast, strong excimer emission was generated by hybridization with one-base deletion mutant. Similarly, two-base deletion was also detected.

Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator Reviewed

H. Asanuma, H. Hayashi, J. Zhao, X. G. Liang, A. Yamazawa, T. Kuramochi, D. Matsunaga, Y. Aiba, H. Kashida, M. Komiyama

Chem. Commun. ( 48 ) page： 5062-5064 2006

Incorporation of methyl group on azobenzene for the effective photo-regulation of hybridization and suppression of thermal isomerization

H. Nishioka, H. Kashida, M. Komiyama, X. G. Liang, H. Asanuma

Nucleic Acids Symp. Ser. Vol. 50 page： 85-86 2006

Interstrand H-aggregation of cationic dyes for narrowing the absorption spectra and stabilizing the duplex Reviewed

H. Kashida, H. Asanuma, M. Komiyama

Supramol. Chem. Vol. 16 ( 6 ) page： 459-464 2004.9

Alternating hetero H aggregation of different dyes by interstrand stacking from two DNA-dye conjugates

H. Kashida, H. Asanuma, M. Komiyama

Angew. Chem. Int. Ed. Vol. 43 ( 47 ) page： 6522-6525 2004

Language：English Publishing type：Research paper (scientific journal)

Heteroaggregates in which two dyes are stacked alternately can be prepared by interstrand stacking from two DNA–dye conjugates. Even different dyes can exhibit an H band as a result of aggregation. The present method is applicable to other functional molecules, and various novel materials can be produced by the attachment of dyes to DNA.

光機能性DNAの設計と応用

浅沼浩之、樫田啓

高分子加工 Vol. 53 ( 1 ) page： 37-43 2004

NMR study on the photoresponsive DNA tethering an azobenzene. Assignment of the absolute configuration of two diastereomers and structure determination of their duplexes in the trans-form Reviewed

X. G. Liang, H. Asanuma, H. Kashida, A. Takasu, T. Sakamoto, G. Kawai, M. Komiyama

J. Am. Chem. Soc. Vol. 125 ( 52 ) page： 16408-16415 2003.12

DNA-dye conjugates for controllable H* aggregation Reviewed

H. Asanuma, K. Shirasuka, T. Takarada, H. Kashida, M. Komiyama

J. Am. Chem. Soc. Vol. 125 ( 8 ) page： 2217-2223 2003.12

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