Updated on 2025/04/08

写真a

 
NISHIJIMA, Ken-ichi
 
Organization
Graduate School of Bioagricultural Sciences Avian Bioscience Research Center Professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences Department of Bioresource Sciences
Title
Professor
Contact information
メールアドレス

Degree 2

  1. 博士(農学) （ 1997.3   東京大学 ） 

  2. 修士(農学) （ 1992.3   東京大学 ） 

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Research Interests 3

  1. Genetic engineering

  2. Animal cell technology

  3. 遺伝子改変鳥類

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Research Areas 2

  1. Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering  / Engineering@Process Engineering@Bioengineering

  2. Life Science / Applied molecular and cellular biology

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Current Research Project and SDGs 4

  1. CHO細胞を用いた物質生産プロセスの効率化

  2. Regulation of immune responses by cellular lectins

  3. Production of Transgenic birds

  4. 遺伝子改変ニワトリを用いたワクチン及び医薬品タンパク質生産システムの開発

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Research History 3

  1. Nagoya University   Professor

    2020.4

  2. Nagoya University   Associate professor

    2012.4 - 2020.3

  3. Department of Biotechnology, Nagoya University   Assistant

    1994.8

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    Country：Japan

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Education 2

  1. The University of Tokyo   Graduate School, Division of Agricultural Science   Applied Biological Chemistry

    - 1992

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    Country： Japan

  2. The University of Tokyo   Faculty of Agriculture   Department of Applied Biological Chemistry

    - 1990

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    Country： Japan

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Professional Memberships 8

  1. 日本動物細胞工学会   庶務幹事

    2011.6

  2. 日本生物工学会

  3. 日本農芸化学会

  4. 化学工学会

  5. 日本生化学会

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Committee Memberships 1

  1. 生物遺伝資源委員会   委員  

    2020.4   

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Awards 5

  1. 日本農芸化学会2018年度大会トピックス賞

    2018.3   日本農芸化学会   培養始原生殖細胞の樹立とCRISPR/Cas9によるeGFPノックインニワトリの作製

    萩原遥太、奥嵜雄也、金岡英徳、飯島信司、西島謙一

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  2. Wiley Blackwell Prize 2014

    2014  

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    Country：Japan

  3. 第17回生物工学論文賞

    2009   日本生物工学会  

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    Country：Japan

    Production of Recombinant Tumor Necrosis Factor Receptor/Fc Fusion Protein by Genetically Manipulated Chickens

  4. 第15回生物工学論文賞

    2007.9   社団法人日本生物工学会  

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    Country：Japan

  5. 日本動物細胞工学会奨励賞

    2006.9   日本動物細胞工学会  

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    Country：Japan

    動物細胞機能の有効利用に関する細胞工学的研究

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Papers 65

  1. Avian bioresources for developmental biology: Chicken and quail resources in the United Kingdom, France, and Japan Reviewed International coauthorship International journal Open Access

    Henderson, L; Okuzaki, Y; Marcelle, C; Mcgrew, MJ; Nishijima, KI

    DEVELOPMENTAL BIOLOGY   Vol. 521   page： 1 - 13   2025.5

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ydbio.2025.02.001

    Open Access

    Web of Science

    PubMed

  2. Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs Reviewed

    Munetoshi Ando, Wenjie Tu, Ken-ichi Nishijima, and Shinji Iijima

    Biochem. Biophys. Res. Commun.   Vol. 369   page： 878-883   2008

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2008.02.111

  3. Mammalian genome research resources available from the National BioResource Project in Japan Reviewed

    Saori Mizuno-Iijima, Shoko Kawamoto, Masahide Asano, Tomoji Mashimo, Shigeharu Wakana, Katsuki Nakamura, Ken-ichi Nishijima, Hitoshi Okamoto, Kuniaki Saito, Sawako Yoshina, Yoshihiro Miwa, Yukio Nakamura, Moriya Ohkuma & Atsushi Yoshiki

    Mammalian Genome     2024.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1007/s00335-024-10063-2

  4. PGC-based cryobanking, regeneration through germline chimera mating, and CRISPR/Cas9-mediated TYRP1 modification in indigenous Chinese chickens Reviewed International coauthorship

    Kinoshita K, Tanabe K, Nakamura Y, Nishijima KI, Suzuki T, Okuzaki Y, Mizushima S, Wang MS, Khan SU, Xu K, Jamal MA, Wei T, Zhao H, Su Y, Sun F, Liu G, Zhu F, Zhao HY, Wei HJ

    Communications Biology   Vol. 7   page： 1127   2024.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/s42003-024-06775-5

  5. Sequential post-translational modifications regulate damaged DNA-binding protein DDB2 function Reviewed

    Hidenori Kaneoka, Kazuhiko Arakawa, Yusuke Masuda, Daiki Ogawa, Kota Sugimoto, Risako Fukata, Maasa Tsuge-Shoji, Ken-ichi Nishijima and Shinji Iijima

    J. Biochem     2024.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/jb/mvae056/7723782

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Books 28

  1. Transgenic chickens Reviewed

    Ken-ichi Nishijima and Shinji Iijima（ Role： Joint author）

    Development, Growth & Differentiation   2013 

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    Language：English Book type：Textbook, survey, introduction

  2. NBRPニワトリ・ウズラリソース事業とデザイン型ゲノム育種への夢

    西島謙一（ Role： Sole author）

    東海畜産学会報　34  2024.3 

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    Responsible for pages：6-7   Language：Japanese

  3. ニワトリ・ウズラの世界は こんなにも豊かだ ─ ナショナルバイオリソースプロジェクトの 現場から

    西島謙一（ Role： Sole author）

    生物の科学　遺伝　77（4）  2023.4 

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    Responsible for pages：54-55   Language：Japanese Book type：General book, introductory book for general audience

  4. 物質生産能の高い育種法の開発と活用

    西島謙一（ Role： Contributor ,  第2章　第7節）

    技術情報協会  2022.11  （ ISBN:978-4-86104-904-0 ）

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    Total pages：553   Responsible for pages：122-129   Language：Japanese Book type：Scholarly book

  5. シグレックと免疫制御 Reviewed

    西島謙一（ Role： Contributor）

    糖鎖生物学.　北島健、佐藤ちひろ、門松健治、加藤晃一編　 名古屋大学出版会  2020.2 

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    Total pages：297   Responsible for pages：237-238   Language：Japanese Book type：Textbook, survey, introduction

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Presentations 6

  1. Chicken/Quail resources in Avian Bioscience Research Center in Nagoya University Invited International conference

    K. Nishijima

    Animal Genomics and Genome Project  2021.11.25 

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    Event date： 2021.11

    Language：English   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

  2. ニワトリ始原生殖細胞の 遺伝子改変への応用 Invited

    西島謙一

    基盤技術整備プログラム成果発表ワークショップ 

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    Event date： 2021.8

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

  3. Genetically Manipulated Chickens as Animal Bioreactor. Invited International conference

    Nishijima, K.; Kaneoka, H.; Iijima, S

    2016 World Congress on In Vitro Biology 

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    Event date： 2016.6

    Language：English   Presentation type：Oral presentation (general)  

    Venue：San Diego   Country：United States  

  4. Toward the understanding of transgenesis property of chicken PGCs International conference

    Ken-ichi Nishijima

    International Forum on Avian Germplasm 2013 

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    Event date： 2013.10

    Language：English   Presentation type：Oral presentation (general)  

    Country：Korea, Republic of  

  5. Siglec-9 inhibits innate immunity International conference

    Sialoglycoscience 2006, Fifth International Conference 

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    Event date： 2006

    Language：English   Presentation type：Poster presentation  

    Country：Japan  

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Research Project for Joint Research, Competitive Funding, etc. 9

  1. 遺伝子改変鶏を利用した新規ワクチン生産プラットフォーム

    2021.4 - 2024.3

    善き未来を拓く科学技術 

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    Authorship：Principal investigator  Grant type：Competitive

    （ Direct Cost: \25000000 ）

  2. ニワトリ糖鎖制御技術の開発と炎症調節への展開

    2018.4 - 2019.3

    水谷糖質科学振興財団　  水谷糖質科学振興財団　第25回研究助成 

    西島謙一

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    Authorship：Principal investigator  Grant type：Competitive

    （ Direct Cost: \3000000 ）

  3. 新規高機能インフルエンザワクチン生産法の確立

    2012.4 - 2013.3

    公益財団法人豊田理化学研究所　平成24年度豊田理研スカラー 

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    Grant type：Competitive

  4. 炎症を制御するシアル酸認識レクチンの機能解析

    2011.12 - 2012.12

    財団法人テルモ科学技術振興財団 2011年度一般研究助成 

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    Grant type：Competitive

  5. トランスジェニックニワトリを用いた高機能インフルエンザワクチン生産法

    2011.12 - 2012.3

    財団法人中部科学技術センター　学術奨励研究助成金 

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    Grant type：Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 11

  1. インフルエンザパンデミック制御におけるニワトリトランスジェニック技術の展開

    Grant number：24K01268  2024.4 - 2028.3

    科学研究費助成事業  基盤研究(B)

    西島 謙一, 高桑 弘樹, 金岡 英徳, 奥嵜 雄也, 内田 裕子

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    Authorship：Principal investigator 

    Grant amount：\18590000 （ Direct Cost: \14300000 、 Indirect Cost：\4290000 ）

    本申請では、ようやく可能となりつつあるニワトリの遺伝子改変技術を最大限生かして、古くから継続する脅威であるインフルエンザに対する対抗技術を開発することを目指す。遺伝子改変ニワトリを利用することで、改善の余地のあるインフルエンザワクチン生産系を飛躍的に効率化することを目指す。合わせて、鳥インフルエンザの流行にも頑健性を持ってワクチン生産システムを維持できるよう、インフルエンザ耐性ニワトリの育種を進める。

  2. Elucidation of the genetic basis for the temperament of chickens and identification of the causal genes

    Grant number：22H02497  2022.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship：Coinvestigator(s) 

  3. Elucidation of the genetic basis for temperament in chickens and identification of causative genes

    Grant number：23K23762  2022.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship：Coinvestigator(s) 

  4. Creation of a design-based breeding process and its application to the production of influenza-resistant chickens

    Grant number：21K18186  2021.7 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Pioneering)

    Nishijima Ken-ichi

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    Authorship：Principal investigator 

    Grant amount：\26000000 （ Direct Cost: \20000000 、 Indirect Cost：\6000000 ）

    We aimed to pick up the naturally occurred gene that confer resistance to avian influenza. Linkage analysis enabled us to estimate the genomic region correlating with influenza resistance. To prove the causative gene by the knockout of the resistance candidate gene, it is necessary to increase the analytical efficiency significantly. For this purpose, we created Cas9-expressing transgenic chickens, which enable genome editing by introducing a small vector to express guide RNAs. We confirmed that a model gene can be knocked-out in vivo by the injection of a virus vector.

  5. Development of integrated animal cell engineering system for biopharmaceutical production

    Grant number：20H00322  2020.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Kamihira Masamichi

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    Authorship：Coinvestigator(s) 

    Based on the gene engineering technology for animal cells that we have developed, we have constructed a cell engineering cycle for the production of functional cells used in biopharmaceutical production and cellular medicines. This has enabled the systematization of functional modification of animal cells. Additionally, as part of the development of original elementary technologies in cell engineering, we have worked on developing new host cells, creating artificial gene expression control systems, producing transgenic chickens using primordial germ cells, and advancing embryo manipulation technology to generate transgenic chickens. We have applied these efforts to the production of biopharmaceuticals and the creation of functional cells, making it possible to design and create cells and chickens with specific functions.

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Teaching Experience (On-campus) 15

  1. 動物遺伝学特論

    2020

  2. 生物化学1

    2020

  3. Core Biochemistry

    2019

  4. 生命システム工学基礎論

    2019

  5. 化学基礎1

    2019

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Teaching Experience (Off-campus) 9

  1. 生物学

    2021.4 - 2021.9 （Aichi Institute of Technology）

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    Level：Undergraduate (liberal arts) 

  2. 医用細胞工学

    2013.4 - 2014.3 （Chubu University）

  3. 生物化学概論

    2012.4 - 2013.3 （Aichi Institute of Technology）

  4. 応用生命科学特別講義II

    2012.4 - 2013.3 （Ishikawa Prefectural University）

  5. 生物化学概論

    2011.4 - 2012.3 （Aichi Institute of Technology）

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