名古屋大学医学部附属病院   糖尿病・内分泌内科   医員

2010.4 - 2010.12

名古屋大学医学部附属病院   糖尿病・内分泌内科   客員研究者

2009.4 - 2010.3

ペンシルバニア大学   研究員

2006.4 - 2009.3

静岡済生会総合病院   内分泌内科

2001.4 - 2002.3

名古屋第二赤十字病院   内分泌内科

2000.4 - 2001.3

名古屋第二赤十字病院　   研修医

1998.5 - 2000.3

日本内科学会

Society for Neuroscience

The Eondocrine Society

北米肥満学会

Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet

Sasaki, T; Sugiyama, M; Kuno, M; Miyata, T; Kobayashi, T; Yasuda, Y; Onoue, T; Takagi, H; Hagiwara, D; Iwama, S; Suga, H; Banno, R; Arima, H

PHYSIOLOGY & BEHAVIOR   Vol. 287   page： 114703   2024.12

Development of pituitary dysfunction and destructive thyroiditis is associated with better survival in non-small cell lung cancer patients treated with programmed cell death-1 inhibitors: a prospective study with immortal time bias correction

Suzuki, K; Kobayashi, T; Izuchi, T; Otake, K; Ando, M; Handa, T; Miyata, T; Sugiyama, M; Onoue, T; Hagiwara, D; Suga, H; Banno, R; Hase, T; Inoue, M; Ishii, M; Arima, H; Iwama, S

FRONTIERS IN ENDOCRINOLOGY   Vol. 15   page： 1490042   2024.11

Age Difference In Muscle Sympathetic Nerve Activity During Passive Leg Raising In Females

Kondo, H; Shiozawa, K; Lee, JB; Saito, M; Ishida, K; Millar, PJ; Seo, N; Banno, R; Ogoh, S; Katayama, K

MEDICINE & SCIENCE IN SPORTS & EXERCISE   Vol. 56 ( 10 ) page： 796 - 796   2024.10

Sex Difference In Muscle Sympathetic Nerve Activity During Passive Leg Raising

Seo, N; Shiozawa, K; Lee, JB; Saito, M; Ishida, K; Millar, PJ; Kondo, H; Banno, R; Ogoh, S; Katayama, K

MEDICINE & SCIENCE IN SPORTS & EXERCISE   Vol. 56 ( 10 ) page： 696 - 696   2024.10

Effects of activation of peripheral sympathetic nerve on glycaemic control in standard chow- and high-fat-fed rats

Sato, D; Miyamoto, L; Banno, R; Kusunoki, M

DIABETOLOGIA   Vol. 67   page： S117 - S117   2024.9

Thyroid autoantibodies at baseline predict longer survival in non-small cell lung cancer patients treated with anti-programmed cell death-1 blockade: a prospective study

Okuji, T; Iwama, S; Kobayashi, T; Yasuda, Y; Ito, M; Yamagami, A; Ando, M; Hase, T; Shibata, H; Hatta, T; Zhou, X; Onoue, T; Kawaguchi, Y; Miyata, T; Sugiyama, M; Hagiwara, D; Suga, H; Banno, R; Ando, Y; Hashimoto, N; Arima, H

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 86 ( 3 ) page： 452 - 463   2024.8

Sympathoinhibition during cardiopulmonary baroreceptor loading is attenuated in older females

Katayama, K; Shiozawa, K; Lee, JB; Kondo, H; Seo, N; Ishida, K; Millar, PJ; Banno, R; Ogoh, S

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   Vol. 327 ( 1 ) page： R88 - R96   2024.7

Combined use of tyrosine kinase inhibitors with PD-(L)1 blockade increased the risk of thyroid dysfunction in PD-(L)1 blockade: a prospective study

Kobayashi, T; Iwama, S; Yamagami, A; Izuchi, T; Suzuki, K; Otake, K; Yasuda, Y; Ando, M; Onoue, T; Miyata, T; Sugiyama, M; Hagiwara, D; Suga, H; Banno, R; Hase, T; Nishio, N; Mori, S; Shimokata, T; Sano, T; Niimi, K; Yoshikawa, N; Akamatsu, S; Ando, Y; Akiyama, M; Sone, M; Ishii, M; Arima, H

CANCER IMMUNOLOGY IMMUNOTHERAPY   Vol. 73 ( 8 ) page： 146   2024.6

Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals

Katayama, K; Shiozawa, K; Lee, JB; Seo, N; Kondo, H; Saito, M; Ishida, K; Millar, PJ; Banno, R; Ogoh, S

JOURNAL OF PHYSIOLOGICAL SCIENCES   Vol. 74 ( 1 ) page： 19   2024.3

Effects of Digitization of Self-Monitoring of Blood Glucose Records Using a Mobile App and the Cloud System on Outpatient Management of Diabetes: Single-Armed Prospective Study

Handa, T; Onoue, T; Kobayashi, T; Maeda, R; Mizutani, K; Yamagami, A; Kinoshita, T; Yasuda, Y; Iwama, S; Miyata, T; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Azuma, Y; Kasai, T; Yoshioka, S; Kuwatsuka, Y; Arima, H

JMIR DIABETES   Vol. 9   page： e48019   2024

Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade

Yamagami, A; Iwama, S; Kobayashi, T; Zhou, X; Yasuda, Y; Okuji, T; Ito, M; Izuchi, T; Ando, M; Onoue, T; Miyata, T; Sugiyama, M; Hagiwara, D; Suga, H; Banno, R; Arima, H

ENDOCRINE JOURNAL   Vol. 71 ( 5 ) page： 515 - 526   2024

Improved glycemic control after the use of flash glucose monitoring accompanied by improved treatment satisfaction in patients with non-insulin-treated type 2 diabetes: A post-hoc analysis of a randomized controlled trial

Hayase, A; Onoue, T; Kobayashi, T; Wada, E; Handa, T; Kinoshita, T; Yamagami, A; Yasuda, Y; Iwama, S; Kawaguchi, Y; Miyata, T; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Kuwatsuka, Y; Ando, M; Goto, M; Arima, H

PRIMARY CARE DIABETES   Vol. 17 ( 6 ) page： 575 - 580   2023.12

Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice

Ito, M; Iwama, S; Sugiyama, D; Yasuda, Y; Okuji, T; Kobayashi, T; Zhou, X; Yamagami, A; Onoue, T; Miyata, T; Sugiyama, M; Hagiwara, D; Suga, H; Banno, R; Nishikawa, H; Arima, H

SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page： 5939   2023.4

Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency.

Kurimoto J, Takagi H, Miyata T, Kawaguchi Y, Hodai Y, Tsumura T, Hagiwara D, Kobayashi T, Yasuda Y, Sugiyama M, Onoue T, Iwama S, Suga H, Banno R, Katsuki T, Ando F, Uchida S, Arima H

Endocrine journal   Vol. 70 ( 3 ) page： 295 - 304   2023.3

Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study

Handa, T; Onoue, T; Kobayashi, T; Wada, E; Hayase, A; Kinoshita, T; Yamagami, A; Yasuda, Y; Iwama, S; Kawaguchi, Y; Miyata, T; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Goto, M; Arima, H

ARCHIVES OF ENDOCRINOLOGY METABOLISM   Vol. 67 ( 2 ) page： 233 - 241   2023.3

Knockdown of endoplasmic reticulum chaperone BiP leads to the death of parvocellular AVP/CRH neurons in mice

Kawaguchi, Y; Hagiwara, D; Tsumura, T; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Yasuda, Y; Iwama, S; Suga, H; Banno, R; Grinevich, V; Arima, H

JOURNAL OF NEUROENDOCRINOLOGY   Vol. 35 ( 1 ) page： e13223   2023.1

Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state

Ozaki, H; Suga, H; Sakakibara, M; Soen, M; Miyake, N; Miwata, T; Taga, S; Nagai, T; Kano, M; Mitsumoto, K; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Takagi, H; Hagiwara, D; Iwama, S; Banno, R; Iguchi, G; Takahashi, Y; Muguruma, K; Inoue, H; Arima, H

SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page： 17381   2022.10

Elevated TSH Level, TgAb, and Prior Use of Ramucirumab or TKIs as Risk Factors for Thyroid Dysfunction in PD-L1 Blockade

Kobayashi, T; Iwama, S; Yamagami, A; Yasuda, Y; Okuji, T; Ito, M; Zhou, X; Ando, M; Onoue, T; Miyata, T; Sugiyama, M; Hagiwara, D; Suga, H; Banno, R; Hase, T; Morise, M; Ito, T; Kikumori, T; Inoue, M; Ando, Y; Masuda, N; Kawashima, H; Hashimoto, N; Arima, H

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   Vol. 107 ( 10 ) page： E4115 - E4123   2022.9

Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin

Ito, Y; Sun, R; Yagimuma, H; Taki, K; Mizoguchi, A; Kobayashi, T; Sugiyama, M; Onoue, T; Tsunekawa, T; Takagi, H; Hagiwara, D; Iwama, S; Suga, H; Konishi, H; Kiyama, H; Arima, H; Banno, R

DIABETES   Vol. 71 ( 9 ) page： 1902 - 1914   2022.9

Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline

Iwama, S; Kobayashi, T; Yasuda, Y; Okuji, T; Ito, M; Ando, M; Zhou, X; Yamagami, A; Onoue, T; Kawaguchi, Y; Miyata, T; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Hase, T; Morise, M; Wakahara, K; Yokota, K; Kato, M; Nishio, N; Tanaka, C; Miyata, K; Ogura, A; Ito, T; Sawada, T; Shimokata, T; Niimi, K; Ohka, F; Ishigami, M; Gotoh, M; Hashimoto, N; Saito, R; Kiyoi, H; Kajiyama, H; Ando, Y; Hibi, H; Sone, M; Akiyama, M; Kodera, Y; Arima, H

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   Vol. 107 ( 4 ) page： E1620 - E1630   2022.3

d-Allulose Improves Endurance and Recovery from Exhaustion in Male C57BL/6J Mice

Liu, BY; Gou, Y; Tsuzuki, T; Yamada, T; Iida, T; Wang, SX; Banno, R; Toyoda, Y; Koike, T

NUTRIENTS   Vol. 14 ( 3 )   2022.2

Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults. Reply to Sugiyama K and Saisho Y [letter]

Wada, E; Onoue, T; Kinoshita, T; Hayase, A; Handa, T; Ito, M; Furukawa, M; Okuji, T; Kobayashi, T; Iwama, S; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Goto, M; Arima, H

DIABETOLOGIA   Vol. 65 ( 1 ) page： 252 - 253   2022.1

Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis

Ryuge, A; Kosugi, T; Maeda, K; Banno, R; Gou, Y; Zaitsu, K; Ito, T; Sato, Y; Hirayama, A; Tsubota, S; Honda, T; Nakajima, K; Ozaki, T; Kondoh, K; Takahashi, K; Kato, N; Ishimoto, T; Soga, T; Nakagawa, T; Koike, T; Arima, H; Yuzawa, Y; Minokoshi, Y; Maruyama, S; Kadomatsu, K

JCI INSIGHT   Vol. 6 ( 20 )   2021.10

Adult-onset autoimmune diabetes identified by glutamic acid decarboxylase autoantibodies: a retrospective cohort study

Wada, E; Onoue, T; Kinoshita, T; Hayase, A; Handa, T; Ito, M; Furukawa, M; Okuji, T; Kobayashi, T; Iwama, S; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Goto, M; Arima, H

DIABETOLOGIA   Vol. 64 ( 10 ) page： 2183 - 2192   2021.10

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats

Gou, Y; Liu, BY; Cheng, MY; Yamada, T; Iida, T; Wang, SX; Banno, R; Koike, T

MOLECULES   Vol. 26 ( 20 )   2021.10

GABA_B receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice

Sun, RN; Tsunekawa, T; Hirose, T; Yaginuma, H; Taki, K; Mizoguchi, A; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Takagi, H; Hagiwara, D; Ito, Y; Iwama, S; Suga, H; Banno, R; Bettler, B; Arima, H

SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 19296   2021.9

Deficiency of WFS1 leads to the impairment of AVP secretion under dehydration in male mice

Kurimoto, J; Takagi, H; Miyata, T; Hodai, Y; Kawaguchi, Y; Hagiwara, D; Suga, H; Kobayashi, T; Sugiyama, M; Onoue, T; Ito, Y; Iwama, S; Banno, R; Tanabe, K; Tanizawa, Y; Arima, H

PITUITARY   Vol. 24 ( 4 ) page： 582 - 588   2021.8

Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice

Mizoguchi, A; Banno, R; Sun, R; Yaginuma, H; Taki, K; Kobayashi, T; Sugiyama, M; Tsunekawa, T; Onoue, T; Takagi, H; Hagiwara, D; Ito, Y; Iwama, S; Suga, H; Nagai, T; Yamada, K; Arima, H

SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 12873   2021.6

CD4<SUP>+</SUP> T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice

Yasuda, Y; Iwama, S; Sugiyama, D; Okuji, T; Kobayashi, T; Ito, M; Okada, N; Enomoto, A; Ito, S; Yan, Y; Sugiyama, M; Onoue, T; Tsunekawa, T; Ito, Y; Takagi, H; Hagiwara, D; Goto, M; Suga, H; Banno, R; Takahashi, M; Nishikawa, H; Arima, H

SCIENCE TRANSLATIONAL MEDICINE   Vol. 13 ( 593 )   2021.5

High-fat feeding causes inflammation and insulin resistance in the ventral tegmental area in mice Reviewed

Akira Mizoguchi, Ryoichi Banno, Runan Sun, Hiroshi Yaginuma, Keigo Taki, Tomoko Kobayashi, Mariko Sugiyama, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Hidetaka Suga, Hiroshi Arima

Neuroscience   Vol. 461   page： 72 - 79   2021.5

Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors

Kobayashi, T; Iwama, S; Sugiyama, D; Yasuda, Y; Okuji, T; Ito, M; Ito, S; Sugiyama, M; Onoue, T; Takagi, H; Hagiwara, D; Ito, Y; Suga, H; Banno, R; Nishikawa, H; Arima, H

JOURNAL FOR IMMUNOTHERAPY OF CANCER   Vol. 9 ( 5 )   2021.5

Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons

Hagiwara, D; Tochiya, M; Azuma, Y; Tsumura, T; Hodai, Y; Kawaguchi, Y; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Takagi, H; Ito, Y; Iwama, S; Suga, H; Banno, R; Arima, H

PEPTIDES   Vol. 139   page： 170517   2021.5

Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet. Reviewed

Taki K, Takagi H, Hirose T, Sun R, Yaginuma H, Mizoguchi A, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Iwama S, Suga H, Banno R, Sakano D, Kume S, Arima H.

PLoS One.     2021.3

Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet

Taki, K; Takagi, H; Hirose, T; Sun, RN; Yaginuma, H; Mizoguchi, A; Kobayashi, T; Sugiyama, M; Tsunekawa, T; Onoue, T; Hagiwara, D; Ito, Y; Iwama, S; Suga, H; Banno, R; Sakano, D; Kume, S; Arima, H

PLOS ONE   Vol. 16 ( 3 ) page： e0248065   2021.3

Deficiency of WFS1 leads to the impairment of AVP secretion under dehydration in male mice. Reviewed

Kurimoto J, Takagi H, Miyata T, Hodai Y, Kawaguchi Y, Hagiwara D, Suga H, Kobayashi T, Sugiyama M, Onoue T, Ito Y, Iwama S, Banno R, Tanabe K, Tanizawa Y, Arima H.

Pituitary     2021.3

Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons. Reviewed

Hagiwara D, Tochiya M, Azuma Y, Tsumura T, Hodai Y, Kawaguchi Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Ito Y, Iwama S, Suga H, Banno R, Arima H.

Peptides     2021.2

Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice

Yaginuma, H; Banno, R; Sun, R; Taki, K; Mizoguchi, A; Kobayashi, T; Sugiyama, M; Tsunekawa, T; Onoue, T; Takagi, H; Hagiwara, D; Ito, Y; Iwama, S; Suga, H; Arima, H

JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 147 ( 4 ) page： 340 - 347   2021

Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice Reviewed

Kawaguchi, Y; Hagiwara, D; Miyata, T; Hodai, Y; Kurimoto, J; Takagi, H; Suga, H; Kobayashi, T; Sugiyama, M; Onoue, T; Ito, Y; Iwama, S; Banno, R; Grinevich, V; Arima, H

SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page： 19730   2020.11

Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons Reviewed

Miyata, T; Hagiwara, D; Hodai, Y; Miwata, T; Kawaguchi, Y; Kurimoto, J; Ozaki, H; Mitsumoto, K; Takagi, H; Suga, H; Kobayashi, T; Sugiyama, M; Onoue, T; Ito, Y; Iwama, S; Banno, R; Matsumoto, M; Kawakami, N; Ohno, N; Sakamoto, H; Arima, H

ISCIENCE   Vol. 23 ( 10 ) page： 101648   2020.10

Peripheral combination treatment of leptin and SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mice

Yaginuma, H; Banno, R; Sun, R; Taki, K; Sugiyama, M; Tsunekawa, T; Takagi, H; Ito, Y; Arima, H

DIABETOLOGIA   Vol. 63 ( SUPPL 1 ) page： S259 - S260   2020.9

The regulation of glucose metabolism by astrocytes in diet induced obesity mice

Sugiyama, M; Banno, R; Sun, R; Yaginuma, H; Taki, K; Takagi, H; Ito, Y; Yamanaka, K; Arima, H

DIABETOLOGIA   Vol. 63 ( SUPPL 1 ) page： S266 - S266   2020.9

Protein tyrosine phosphatase 1B deficiency enhances leptin action to improve glucose homeostasis in IDDM treatment with leptin

Ito, Y; Banno, R; Sun, R; Yaginuma, H; Taki, K; Sugiyama, M; Tsunekawa, T; Takagi, H; Arima, H

DIABETOLOGIA   Vol. 63 ( SUPPL 1 ) page： S12 - S12   2020.9

Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions Reviewed

Sugiyama Mariko, Banno Ryoichi, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Komine Okiru, Yamanaka Koji, Arima Hiroshi

NEUROCHEMISTRY INTERNATIONAL   Vol. 136   page： 104733   2020.6

Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study Reviewed

Okada Norio, Iwama Shintaro, Okuji Takayuki, Kobayashi Tomoko, Yasuda Yoshinori, Wada Eri, Onoue Takeshi, Goto Motomitsu, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Kanda Mitsuro, Yokota Kenji, Hashimoto Naozumi, Ando Masahiko, Fujimoto Yasushi, Nagino Masato, Kodera Yasuhiro, Fujishiro Mitsuhiro, Hibi Hideharu, Sone Michihiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

BRITISH JOURNAL OF CANCER   Vol. 122 ( 6 ) page： 771 - 777   2020.3

Dipeptidyl peptidase-4 inhibitor anagliptin reduces fasting apolipoprotein B-48 levels in patients with type 2 diabetes: A randomized controlled Reviewed

Onoue Takeshi, Goto Motomitsu, Wada Eri, Furukawa Mariko, Okuji Takayuki, Okada Norio, Kobayashi Tomoko, Iwama Shintaro, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Seino Yusuke, Suga Hidetaka, Banno Ryoichi, Hamada Yoji, Ando Masahiko, Yamamori Etsuko, Arima Hiroshi

PLOS ONE   Vol. 15 ( 1 ) page： e0228004   2020.1

Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells Reviewed

Kasai Takatoshi, Suga Hidetaka, Sakakibara Mayu, Ozone Chikafumi, Matsumoto Ryusaku, Kano Mayuko, Mitsumoto Kazuki, Ogawa Koichiro, Kodani Yu, Nagasaki Hiroshi, Inoshita Naoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Takahashi Jun, Arima Hiroshi

CELL REPORTS   Vol. 30 ( 1 ) page： 18 - +   2020.1

Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial Reviewed

Wada Eri, Onoue Takeshi, Kobayashi Tomoko, Handa Tomoko, Hayase Ayaka, Ito Masaaki, Furukawa Mariko, Okuji Takayuki, Okada Norio, Iwama Shintaro, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Kuwatsuka Yachiyo, Ando Masahiko, Goto Motomitsu, Arima Hiroshi

BMJ OPEN DIABETES RESEARCH & CARE   Vol. 8 ( 1 )   2020.1

Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study Reviewed

Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Okuji Takayuki, Ito Masaaki, Onoue Takeshi, Goto Motomitsu, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Fujimoto Yasushi, Hibi Hideharu, Sone Michihiko, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

JOURNAL FOR IMMUNOTHERAPY OF CANCER   Vol. 8 ( 2 )   2020

Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion Reviewed

Takagi Hiroshi, Hagiwara Daisuke, Handa Tomoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Takahashi Kunihiko, Matsui Shigeyuki, Arima Hiroshi

ENDOCRINE JOURNAL   Vol. 67 ( 3 ) page： 267 - 274   2020

GABA(B) Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet Reviewed

Tsunekawa Taku, Banno Ryoichi, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Bettler Bernhard, Arima Hiroshi

ISCIENCE   Vol. 20   page： 337 - +   2019.10

Improved methods for the differentiation of hypothalamic vasopressin neurons using mouse induced pluripotent stem cells Reviewed

Mitsumoto Kazuki, Suga Hidetaka, Sakakibara Mayu, Soen Mika, Yamada Tomiko, Ozaki Hajime, Nagai Takashi, Kano Mayuko, Kasai Takatoshi, Ozone Chikafumi, Ogawa Koichiro, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Arima Hiroshi

STEM CELL RESEARCH   Vol. 40   page： 101572   2019.10

Tanycyte-Like Cells Derived From Mouse Embryonic Stem Culture Show Hypothalamic Neural Stem/Progenitor Cell Functions. Reviewed

Kano M, Suga H, Ishihara T, Sakakibara M, Soen M, Yamada T, Ozaki H, Mitsumoto K, Kasai T, Sugiyama M, Onoue T, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Iwama S, Goto M, Banno R, Arima H

Endocrinology   Vol. 160 ( 7 ) page： 1701-1718   2019.7

Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus Reviewed

Tochiya Masayoshi, Hagiwara Daisuke, Azuma Yoshinori, Miyata Takashi, Morishita Yoshiaki, Suga Hidetaka, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Arima Hiroshi

NEUROSCIENCE LETTERS   Vol. 682   page： 50 - 55   2018.8

Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis Reviewed

Yasuda Yoshinori, Iwama Shintaro, Kiyota Atsushi, Izumida Hisakazu, Nakashima Kohtaro, Iwata Naoko, Ito Yoshihiro, Morishita Yoshiaki, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Enomoto Atsushi, Takahashi Masahide, Arima Hiroshi, Sugimura Yoshihisa

JOURNAL OF PATHOLOGY   Vol. 244 ( 4 ) page： 469 - 478   2018.4

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study Reviewed

Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

JOURNAL OF THE ENDOCRINE SOCIETY   Vol. 2 ( 3 ) page： 241 - 251   2018.3

Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors Reviewed

Ogawa Koichiro, Suga Hidetaka, Ozone Chikafumi, Sakakibara Mayu, Yamada Tomiko, Kano Mayuko, Mitsumoto Kazuki, Kasai Takatoshi, Kodani Yu, Nagasaki Hiroshi, Yamamoto Naoki, Hagiwara Daisuke, Goto Motomitsu, Banno Ryoichi, Sugimura Yoshihisa, Arima Hiroshi

SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page： 3615   2018.2

Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors. Reviewed

Ogawa K, Suga H, Ozone C, Sakakibara M, Yamada T, Kano M, Mitsumoto K, Kasai T, Kodani Y, Nagasaki H, Yamamoto N, Hagiwara D, Goto M, Banno R, Sugimura Y, Arima H.

Sci Rep.   Vol. 8 ( 1 ) page： 3615   2018.2

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study. Reviewed

Kobayashi T, Iwama S, Yasuda Y, Okada N, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Morishita Y, Goto M, Suga H, Banno R, Yokota K, Hase T, Morise M, Hashimoto N, Ando M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H.

J Endocr Soc.   Vol. 2 ( 3 ) page： 241-251   2018.2

Sequestosome 1 (SQSTMI/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture Reviewed

Tominaga Takashi, Goto Motomitsu, Onoue Takeshi, Mizoguchi Akira, Sugiyama Mariko, Tsunekawa Taku, Hagiwara Daisuke, Morishita Yoshiaki, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Arima Hiroshi

NEUROSCIENCE LETTERS   Vol. 656   page： 103 - 107   2017.8

PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions

Sugiyama Mariko, Banno Ryoichi, Mizoguchi Akira, Tominaga Takashi, Tsunekawa Taku, Onoue Takeshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Arima Hiroshi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 488 ( 1 ) page： 116 - 121   2017.6

Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis

Iwata Naoko, Iwama Shintaro, Sugimura Yoshihisa, Yasuda Yoshinori, Nakashima Kohtaro, Takeuchi Seiji, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Goto Motomitsu, Banno Ryoichi, Caturegli Patrizio, Koike Teruhiko, Oshida Yoshiharu, Arima Hiroshi

PITUITARY   Vol. 20 ( 3 ) page： 301 - 310   2017.6

Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia Reviewed

Tsunekawa Taku, Banno Ryoichi, Mizoguchi Akira, Sugiyama Mariko, Tominaga Takashi, Onoue Takeshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Sugimura Yoshihisa, Arima Hiroshi

EBIOMEDICINE   Vol. 16   page： 172 - 183   2017.2

Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis. Reviewed

Iwata N, Iwama S, Sugimura Y, Yasuda Y, Nakashima K, Takeuchi S, Hagiwara D, Ito Y, Suga H, Goto M, Banno R, Caturegli P, Koike T, Oshida Y, Arima H.

Pituitary   Vol. 20 ( 3 ) page： 301-310   2016.11

Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. Reviewed

Ji S, Tokizane K, Ohkawa Y, Ohmi Y, Banno R, Okajima T, Kiyama H, Furukawa K, Furukawa K.

Biochem Biophys Res Commun.   Vol. 479 ( 3 ) page： 453-460   2016.10

Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus. Reviewed

Onoue T, Goto M, Tominaga T, Sugiyama M, Tsunekawa T, Hagiwara D, Banno R, Suga H, Sugimura Y, Arima H.

Neuroscience Letters   Vol. 619   page： 1-7   2016.4

AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat Diet. Reviewed

Shibata M, Banno R, Sugiyama M, Tominaga T, Onoue T, Tsunekawa T, Azuma Y, Hagiwara D, Lu W, Ito Y, Goto M, Suga H, Sugimura Y, Oiso Y, Arima H.

Endocrinology   Vol. 157 ( 4 ) page： 1457-1466   2016.2

Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice. Reviewed

Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Arima H.

Neurosci Lett.   Vol. 612   page： 199-203   2016.1

BMP4 and FGF strongly induce differentiation of mouse ES cells into oral ectoderm. Reviewed

Ochiai H, Suga H, Yamada T, Sakakibara M, Kasai T, Ozone C, Ogawa K, Goto M, Banno R, Tsunekawa S, Sugimura Y, Arima H, Oiso Y

Stem Cell Res.   Vol. 15 ( 2 ) page： 290-8   2015.7

b-Series gangliosides crucially regulate leptin secretion in adipose tissues Reviewed

Ji S, Ohkawa Y, Tokizane K, Ohmi Y, Banno R, Furukawa K, Kiyama H, Furukawa K

Biochem Biophys Res Commun   Vol. 459 ( 2 ) page： 189-95   2015.4

Activating Transcription Factor 6α Is Required for the Vasopressin Neuron System to Maintain Water Balance under Dehydration in Male Mice. Reviewed

Azuma Y, Hagiwara D, Lu W, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Shiota A, Asai N, Takahashi M, Oiso Y, Arima H.

Endocrinology     2014.9

Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus. Reviewed

Adachi K, Goto M, Onoue T, Tsunekawa T, Shibata M, Hagimoto S, Ito Y, Banno R, Suga H, Sugimura Y, Oiso Y, Arima H.

Neurosci Lett.   Vol. 569   page： 49-54   2014.5

Minocycline prevents osmotic demyelination associated with aquaresis. Reviewed

Takagi H, Sugimura Y, Suzuki H, Iwama S, Izumida H, Fujisawa H, Ogawa K, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Suga H, Goto M, Banno R, Arima H, Oiso Y.

Kidney Int.   Vol. 86 ( 5 ) page： 954-64   2014.4

Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus. Reviewed

Hagiwara D, Arima H, Morishita Y, Wenjun L, Azuma Y, Ito Y, Suga H, Goto M, Banno R, Sugimura Y, Shiota A, Asai N, Takahashi M, Oiso Y.

Cell Death Dis.   Vol. 5 ( e1148 )   2014.3

GABA Type B Receptor Signaling in Proopiomelanocortin Neurons Protects Against Obesity, Insulin Resistance, and Hypothalamic Inflammation in Male Mice on a High-Fat Diet. Reviewed

Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Hagiwara D, Ozawa Y, Goto M, Suga H, Sugimura Y, Bettler B, Oiso Y, Arima H.

J Neurosci.   Vol. 33 ( 43 ) page： 17166-17173   2013.10

Expression of neuropeptide Y and agouti-related protein mRNA stimulated by glucocorticoids is attenuated via NF-κB p65 under ER stress in mouse hypothalamic cultures. Reviewed

Hagimoto S, Arima H, Adachi K, Ito Y, Suga H, Sugimura Y, Goto M, Banno R, Oiso Y.

Neurosci Lett.   Vol. 11 ( 553 ) page： 165-169   2013.8

Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide Y gene in rats. Reviewed

Ozawa Y, Arima H, Banno R, Ito Y, Goto M, Morishita Y, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y.

Neuroreport.   Vol. 1 ( 23 ) page： 673-5   2012.8

BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice. Reviewed

Hagiwara D, Arima H, Morishita Y, Goto M, Banno R, Sugimura Y, Oiso Y.

Peptides.   Vol. 33 ( 2 ) page： 346-50   2012.1

TNFα increases hypothalamic PTP1B activity via the NFκB pathway in rat hypothalamic organotypic cultures. Reviewed

Ito Y, Banno R, Hagimoto S, Ozawa Y, Arima H, Oiso Y.

Regul Pept.   Vol. 10 ( 174 ) page： 58-64   2011.12

Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. Reviewed

De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK

Am J Physiol Endocrinol Metab.   Vol. 300 ( 6 ) page： 1002-1011   2011.6

Repeated glucoprivation delayed hyperphagic responses while activating neuropeptide Y neurons in rats. Reviewed

Ozawa Y, Arima H, Watanabe M, Shimizu H, Ito Y, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y

Peptides   Vol. 32 ( 4 ) page： 763-769   2011.4

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. Reviewed

Banno R, Zimmer D, De Jonghe BC, Atienza M, Rak K, Yang WT, Bence KK

J Clin Invest.   Vol. 120 ( 3 ) page： 720-734   2010.3

Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Reviewed

Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y

Peptides.   Vol. 31 ( 1 ) page： 145-149   2010.1

The medial hypothalamus is required for the feeding response to glucoprivation but not to food deprivation. Reviewed

Watanabe M, Arima H, Ozawa Y, Goto M, Shimizu H, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y

Neurosci Lett.   Vol. 464 ( 1 ) page： 6-9   2009.10

Direct and indirect modulation of neuropeptide Y gene expression in response to hypoglycemia in rat arcuate nucleus. Reviewed

Watanabe M, Arima H, Fukushima K, Goto M, Shimizu H, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y

FEBS Lett.   Vol. 582   page： 3632-3638   2008.10

Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats. Reviewed

Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y

Endocrinology.   Vol. 149 ( 9 ) page： 4544-4553   2008.9

Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice. Reviewed

Sato I, Arima H, Ozaki N, Ozaki N, Watanabe M, Goto M, Shimizu H, Hayashi M, Banno R, Nagasaki H, Oiso Y

FEBS Lett.   Vol. 581 ( 25 ) page： 4857-4864   2007.10

Insulin is not a prerequisite for rapid regulation of neuropeptide Y gene transcription in the arcuate nucleus in food-restricted rats. Reviewed

Goto M, Arima H, Hiroi M, Shimizu H, Watanabe M, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y

Neurosci Lett.   Vol. 420 ( 1 ) page： 61-65   2007.6

Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats. Reviewed

Banno R, Arima H, Hayashi M, Goto M, Watanabe M, Sato I, Ozaki N, Nagasaki H, Ozaki N, Oiso Y

FEBS Lett.   Vol. 581 ( 6 ) page： 1131-1136   2007.3

Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures. Reviewed

Goto M, Arima H, Watanabe M, Hayashi M, Banno R, Sato I, Nagasaki H, Oiso Y

Endocrinology.   Vol. 147 ( 11 ) page： 5102-5109   2006.11

Vasopressin gene transcription increases in response to decreases in plasma volume, but not to increases in plasma osmolality, in chronically dehydrated rats. Reviewed

Hayashi M, Arima H, Goto M, Banno R, Watanabe M, Sato I, Nagasaki H, Oiso Y

Am J Physiol Endocrinol Metab.   Vol. 290 ( 2 ) page： 213-217   2006.2

Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems. Reviewed

Sato I, Arima H, Ozaki N, Watanabe M, Goto M, Hayashi M, Banno R, Nagasaki H, Oiso Y

J Neurosci.   Vol. 25 ( 38 ) page： 8657-8664   2005.9

The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Reviewed

Banno R, Arima H, Sato I, Hayashi M, Goto M, Sugimura Y, Murase T, Oiso Y

Peptides.   Vol. 25 ( 8 ) page： 1279-1286   2004.8

Leukemia inhibitory factor stimulates vasopressin release in rats. Reviewed

Ishizaki S, Murase T, Sugimura Y, Banno R, Arima H, Miura Y, Oiso Y

Neurosci Lett.   Vol. 359   page： 77-80   2004.4

Osmoregulation of vasopressin release and gene transcription under acute and chronic hypovolemia in rats. Reviewed

Kondo N, Arima H, Banno R, Kuwahara S, Sato I, Oiso Y

Am J Physiol Endocrinol Metab.   Vol. 286 ( 3 ) page： 337-346   2004.3

Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures. Reviewed

Kuwahara S, Arima H, Banno R, Sato I, Kondo N, Oiso Y

J Neurosci.   Vol. 23 ( 32 ) page： 10231-10237   2003.11

レプチン抵抗性

坂野僚一（ Role： Sole author）

メディカルレビュー社  2016.1 

PTP1B in the reward system promotes rewarding effects of a high-fat diet. International conference

Banno R

2024.6 

Voluntary wheel running improves a high-fat diet-induced inflammation and insulin resistance in hypothalamic arcuate nucleus and ventral tegmental area in male mice. International conference

21st International Congress of Endocrinology 

糖・エネルギー代謝におけるPTP1Bの役割について Invited

坂野僚一

大学共同利用機関法人 自然科学研究機構 生理学研究所 研究会「臓器連関による生体恒常性維持機構と生体活動の統合的理解」  2024.1.28  生理学研究所

Closing remarks Invited International conference

坂野僚一

第44回日本肥満学会 日韓台肥満学会合同シンポジウム  2023.11.25  日本肥満学会

自発運動は高脂肪食摂取に伴う脳内のインスリン抵抗性を改善する

第44回日本肥満学会 

報酬系ニューロンにおけるPTP1B欠損は高脂肪食の過剰摂取を抑制する

第44回日本肥満学会 

基礎代謝に着目した減量指導の一例

第61回全国大学保健管理研究集会 

減量術前後に基礎代謝、体組成の変化を観察し得た2型糖尿病合併高度肥満症の1例

第97回日本糖尿病学会中部地方会 

高脂肪食摂取により生じる視床下部弓状核と中脳 腹側被蓋野の炎症は自発運動により抑制される

第96回日本内分泌学会学術総会  2023.6.2  日本内分泌学会

線条体ニューロンにおけるPTP1Bは高脂肪食に対する報酬効果を増強する

久納光皓, 坂野僚一, 王思嫻, 佐々木智之, 孫汝楠, 廣瀬友矩, 杉山摩利子, 髙木博史, 有馬寛

第96回日本内分泌学会学術総会  2023.6.2  日本内分泌学会

高脂肪食摂取に伴う脳内炎症がエネルギー代謝に与える影響について Invited

杉山摩利子, 坂野僚一, 有馬寛

第96回日本内分泌学会学術総会　JES We Can  

Dapagliflozinは脂質と食塩の過剰摂取によって生じる 耐糖能異常を改善する

第66回日本糖尿病学会年次学術集会  2023.5.13  日本糖尿病学会

高脂肪食摂取に伴う中脳腹側被蓋野の炎症によりドーパミンシグナルが活性化され過食が生じる

孫汝楠, 杉山摩利子, 久納光皓, 王思嫻, 佐々木智之, 廣瀬友矩, 恒川卓, 髙木博史, 坂野僚一, 有馬寛

第43回日本肥満学会  2022.12 

Dapagliflozinは脂質と食塩の過剰摂取によって生じる耐糖能異常を改善する Invited

髙木博史, 廣瀬友矩, 久納光皓, 佐々木智之, 孫汝楠, 杉山 摩利子, 坂野僚一, 有馬寛

大学共同利用機関法人 自然科学研究機構 生理学研究所 研究会「運動器／代謝系連関による生体機能制御とその変容の仕組み」  2022.11 

Inflammation in VTA induced by HFD activates dopaminergic neurons leading to overeating International conference

R. Sun, M. Sugiyama, M. Kuno, S. Ou, T. Sasaki, T. Hirose, T. Tsunekawa, H. Takagi, R. Banno, and H. Arima

ObesityWeek 2022  2022.11 

中脳腹側被蓋野ドーパミンニューロンにおけるPTP1Bは高脂肪食に対する報酬効果を増強する

王思嫻, 坂野僚一, 苟楊, 劉氷陽, 孫汝楠, 佐々木智之, 廣瀬友矩, 杉山摩利子, 有馬寛, 小池晃彦

第95回日本内分泌学会学術総会  2022.6 

レプチン投与はPTP1B欠損下で インスリン依存性糖尿病モデルマウスの糖代謝を改善する Invited

坂野僚一

大学共同利用機関法人 自然科学研究機構 生理学研究所 研究会「運動器／代謝系連関による生体機能制御とその変容の仕組み」  2021.12.19  自然科学研究機構 生理学研究所

PTP1B in Ventral Tegmental Area Neurons Increases the Rewarding Value of a High-Fat Diet in Mice International conference

Banno R, Wang S, Gou Y, Liu B, Sun R, Sasaki T, Hirose T, Sugiyama M, Arima H, and Koike T

ObesityWeek  2021.11  THE OBESITY SOCIETY

Inflammation in the ventral tegmental area by HFD increases refeeding consumption after fasting. International conference

Sun R, Sugiyama M, Sasaki T, Hirose T, Tsunekawa T, Takagi H, Banno R, and Arima H

ObesityWeek  2021.11  THE OBESITY SOCIETY

食塩と脂質の過剰摂取が体重、糖代謝に与える影響

高木博史, 滝 啓吾, 坂野僚一, 有馬 寛

2020年度生理学研究会「運動器／代謝系連関による生体機能制御とその変容の仕組み」  2020.12.20  生理学研究所

インスリン依存性糖尿病モデルマウスの糖代謝はインスリン非投与下でレプチンおよびSGLT2阻害剤の併用投与により改善する

柳沼裕史, 坂野僚一, 孫 汝楠, 滝 啓吾, 杉山摩利子, 恒川 卓, 髙木博史, 伊藤禎浩, 有馬 寛

第63回日本糖尿病学会年次学術集会  2020.10  日本糖尿病学会

Protein tyrosine phosphatase 1B deficiency enhances leptin action to improve glucose homeostasis in IDDM treatment with leptin. International conference

Y. Ito, R. Banno, R. Sun, H. Yaginuma, K. Taki, M. Sugiyama, H. Takagi, and H. Arima.

EASD Annual Meeting 2020  2020.9.22  欧州糖尿病学会

Peripheral combination treatment of leptin and SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice. International conference

H. Yaginuma, R. Banno, R. Sun, K. Taki, M. Sugiyama, T. Tsunekawa, H. Takagi, Y. Ito, and H. Arima

EASD Annual Meeting 2020  2020.9.23 

The regulation of glucose metabolism by astrocytes in diet induced obesity mice International conference

M. Sugiyama, R. Banno, R. Sun, H. Yaginuma, K. Taki, H. Takagi, Y. Ito, K. Yamanaka, and Arima H

EASD Annual Meeting 2020  2020.9.24 

インスリンを使用することなく血糖値を正常化する治療法 Invited

坂野僚一

日本IDDMネットワークサイエンスフォーラム  2020.9  認定特定非営利活動法人 日本IDDMネットワーク

タモキシフェン誘導性Creマウスを用いたアストロサイト特異的PTP1B欠損マウスの表現型解析

杉山摩利子, 坂野僚一, 孫 汝楠, 柳沼裕史, 滝 啓吾, 恒川 卓, 髙木博史, 伊藤禎浩, 有馬 寛

第93回日本内分泌学会学術総会　  2020.8  日本内分泌学会

GABAB receptor signaling in striatal neurons suppresses binge-like eating of a high fat diet in mice International conference

Tsunekawa T, Banno R, Sun R, Yaginuma H, Taki T, Sugiyama M, Takagi H, Ito Y, Arima H

2019 ObesityWeek  2019.11.5 

Mice lacking PTP1B in astrocyte increases energy expenditure due to enhanced leptin sensitivity International conference

Sugiyama M, Banno R, Sun R, Yaginuma H, Taki T, Tsunekawa T, Takagi H, Ito Y, Yamanaka K, Arima H

2019 ObesityWeek  2019.11.6 

High-fat feeding causes inflammation and insulin resistance in ventral tegmental area in mice International conference

Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Sugiyama M, Tsunekawa T, Takagi H, Ito Y, Arima H

2019 ObesityWeek  2019.11.6 

Baclofenは線条体のドーパミン受容体シグナルを抑制して高脂肪食摂取を抑制する

恒川卓、坂野僚一、孫汝楠、柳沼裕史、滝啓吾、杉山摩利子、髙木博史、伊藤禎浩、有馬寛

第40回日本肥満学会  2019.11.3  日本肥満学会

アストロサイト特異的PTP1B欠損マウスはレプチン感受性およびエネルギー消費が亢進する

杉山摩利子、坂野僚一、孫汝楠、柳沼裕史、滝啓吾、恒川卓、髙木博史、伊藤禎浩、山中宏二、有馬寛

第40回日本肥満学会  2019.11.3  日本肥満学会

糖・エネルギー代謝調節におけるPTP1Bの役割について Invited

坂野僚一

岡崎生理学研究所　研究会　  2019.9.22  生理学研究所

レプチンおよびSGLT2阻害剤の併用投与はインスリン依存性糖尿病モデルマウスの糖代謝を改善する

柳沼裕史、坂野僚一、滝啓吾、溝口暁、杉山摩利子、恒川卓、髙木博史、伊藤禎浩、有馬寛

第62回日本糖尿病学会年次学術集会  2019.5.25  日本糖尿病学会

高脂肪食投与に伴う視床下部弓状核の炎症はアストロサイト特異的PTP1B欠損マウスにおいて減弱する

杉山摩利子、坂野僚一、柳沼裕史、滝啓吾、溝口暁、恒川卓、髙木博史、伊藤禎浩、山中宏二、有馬寛

第92回日本内分泌学会学術総会  2019.5.11  日本内分泌学会

中脳腹側被蓋野ドーパミンニューロンにおけるグルココルチコイド受容体シグナルはストレス下において高脂肪食への嗜好形成を増強する

溝口暁、坂野僚一、柳沼裕史、滝啓吾、杉山摩利子、髙木博史、伊藤禎浩、有馬寛

第92回日本内分泌学会学術総会  2019.5.10  日本内分泌学会

PTP1B deficiency enhances leptin action to improve glucose homeostasis in IDDM International conference

Y ITO, R. BANNO, H. YAGINUMA, K. TAKI, A. MIZOGUCHI, M. SUGIYAMA, T. TSUNEKAWA, H. TAKAGI, H. ARIMA

Neuroscience 2018  2018.11.5  Neuroscience 2018

High-fat feeding causes microglial activation and inflammation in ventral tegmental area in mice

Mizoguchi A, Banno R, Yaginuma H, Taki K, Sugiyama M, Tsunekawa T, Takagi H, Ito Y, Arima H

Neuroscience 2018  2018.11.6 

Mice lacking PTP1B in astrocyte protect against obesity induced by a high fat diet International conference

Sugiyama M, Banno R, Yaginuma H, Taki T, Mizoguchi A, Tsunekawa T, Takagi H, Ito Y, Yamanaka K, Arima H

Neuroscience 2018  2018.11.6  Neuroscience 2018

GABAB receptor signaling in dopaminergic or striatal neurons suppresses food intake during intermittent access to a high fat diet in mice International conference

T. TSUNEKAWA, R. BANNO, H. YAGINUMA, K. TAKI, A. MIZOGUCHI, M. SUGIYAMA, H. TAKAGI, Y. ITO, H. ARIMA

Neuroscience 2018  2018.11.4  Neuroscience 2018

Analysis of roles of glial cell subtypes in hypothalamic inflammation induced by a high fat diet International conference

Sugiyama M, Banno R, Taki K, Mizoguchi A, Tsunekawa T, Takagi H, Ito Y, Komine O, Yamanaka K, Arima H

2017 Obesity Week 

Baclofen suppresses food intake during scheduled feeding on a high fat diet in mice International conference

Sugiyama M, Banno R, Taki K, Mizoguchi A, Tsunekawa T, Takagi H, Ito Y, Komine O, Yamanaka K, Arima H

2017 Obesity Week 

PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression with insulin treatment. International conference

Sugiyama M, Banno R, Mizoguchi A, Tominaga T, Onoue T, Tsunekawa T, Ito Y, Goto M, Arima H

The Obesity Society's 2016 Annual Meeting 

Deficiency of PTP1B attenuates hypothalamic inflammation induced by high fat diet via the activation of JAK2-STAT3 signaling pathway in the microglial cells International conference

Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, Ito Y, Goto M, Arima H

The Obesity Society's 2016 Annual Meeting 

Deficiency of PTP1B attenuates hypothalamic inflammation via the activation of Jak2-Stat3 signaling pathway in the microglial cells under high fat diet conditions International conference

Banno R, Sugiyama M, Tominaga T, Tsunekawa T, Onoue T, Goto M, Arima H.

Keystone Symposia 2015 

Mechanisms by which PTP1B affects energy balance. Invited International conference

Banno R

The 46th NIPS International Symposium 

AgRP neuron-specific deletion of glucocorticoid receptor leads to decreased body weight and adiposity in mice. International conference

Shibata M, Banno R, Onoue T, Tsunekawa T, Adachi K, Ito Y, Goto M, Arima H, Oiso Y

The joint meeting of International Congress of Endocrinology and Endocrine Society (ICE/ENDO 2014) 

GABA type B receptor signaling in proopiomelanocortin neurons is protective against obesity, insulin resistance and hypothalamic inflammation in male mice on a high fat diet. International conference

Banno R, Ito Y, Shibata M, Adachi K, Hagimoto S, Goto M, Bettler B, Oiso Y, Arima H

The 36th Naito Conference on Molecular Aspects of Energy Balance and Feeding Behavior 

POMC neuron-specific deficiency of GABAB receptor leads to obesity on a high fat diet. International conference

Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Goto M, Bettler B, Oiso Y, Arima H

Neuroscience 2012 

TNFα increases hypothalamic PTP1B expression via the NFκB pathway in rat hypothalamic organotypic cultures. International conference

Ito Y, Banno R, Hagimoto S, Ozawa Y, Arima H, Oiso Y

The Endocrine Society's 93th Annual Meeting 

Examination of Neuronal PTP1B in Cold-Induced Thermogenesis. International conference

De Jonghe B, Hayes MR, Banno R, Skibicka K, Zimmer D, Leichner TM, Alhadeff A, Bowen K, Kanoski S, Grill HJ, Bence KK

28th Annual Scientific Meeting of the Obesity Society 

Tumor necrosis factor-α increases protein tyrosine phosphatase 1B activity in rat hypothalamic organotypic cultures. International conference

Ito Y, Banno R, Ozawa Y, Arima H, Oiso Y

The Endocrine Society's 93th Annual Meeting 

PTP1B-or SHP2-deficiency in POMC neurons reciprocally regulates energy balance and glucose homeostasis. International conference

Banno R, Zimmer D, Atienza M, Rak K, Yang WT, Bence KK

14th International Congress of Endocrinology (ICE2010) 

PTP1B-or SHP2-deficiency in POMC Neurons Reciprocally Regulates Body Weight, Glucose Homeostasis, and Hepatic Steatosis. International conference

Banno R, Zimmer D, Atienza M, Rak K, Yang WT, Bence KK

27th Annual Scientific Meeting of the Obesity Society 

Reciprocal regulation of body weight and glucose homeostasis by the protein tyrosine phosphatases PTP1B and SHP2 in POMC neurons. International conference

Banno R, Zimmer D, Atienza M, Bence KK

Society for Neuroscience 38th annual meeting 

Mice with POMC neuron-specific deletion of protein tyrosine phosphatase 1B (PTP1B) show mild protection from diet-induced obesity and significantly improved glucose homeostasis. International conference

Banno R, Zimmer D, Atienza M, Bence KK

Mice with POMC neuron-specific deletion of protein tyrosine phosphatase 1B (PTP1B) show mild protection from diet-induced obesity and significantly improved glucose homeostasis. 

Central administration of melanotan II, a melanocortin agonist, decreased the size of adipocyte and increased the serum levels of adiponectin and leptin in diet-induced obesity rats. International conference

Banno R, Arima H, Goto M, Hayashi M, Watanabe M, Sato I, Oiso Y

Society for Neuroscience 35th annual meeting 

NPYニューロンに発現するグルココルチコイドレセプターの機能解析

2011.4 - 2014.3

科学研究費補助金  基盤研究(C)

自発運動が肥満における高脂肪食への食嗜好を抑制する機序の解明

Grant number：24K14503  2024.4 - 2027.3

科学研究費助成事業  基盤研究(C)

杉山 摩利子, 有馬 寛, 坂野 僚一

Regulation of Glucose Metabolism by Leptin

Grant number：24K10033  2024.4 - 2027.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Application of sports science to exercise on diabetes management - Based on muscle and brain insulin resistance

Grant number：20K11386  2020.4 - 2023.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Koike Teruhiko

The role of Protein Tyrosine Phosphatase 1B in the reward system under a high fat diet condition

Grant number：18K08473  2018.4 - 2021.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Banno Ryoichi

Analysis of the rewards GABAB system in energy balance

Grant number：15K09426  2015.4 - 2018.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Arima Hiroshi

The role of protein tyrosine phosphatase-1B in the hypothalamic inflammation induced by a high fat diet

Grant number：15K09381  2015.4 - 2018.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Banno Ryoichi

基礎医学セミナー

2023

基礎医学セミナー

2022

ベーシックトレーニング

2022

修士課程「社会医学」講義

2022

修士課程「社会医学」講義

2021

ベーシックトレーニング

2021

基礎医学セミナー

2021

基礎医学セミナー

2020

ベーシックトレーニング

2020

修士課程「社会医学」講義

2020

健康・スポーツ科学講義

2019

基礎医学セミナー

2019

ベーシックトレーニング

2019

修士課程「社会医学」講義

2019

健康・スポーツ科学講義

2018

基礎医学セミナー

2018

ベーシックトレーニング

2018

修士課程「社会医学」講義

2018

Nagoya J Med Sci

Role(s)：Peer review

2021.7

Scientific Reports

Role(s)：Peer review

2021.4

Nagoya J Med Sci

Role(s)：Peer review

2020.6

The Journal of Physiology

Role(s)：Peer review

2019.11

Nagoya J Med Sci

Role(s)：Peer review

2018.2