Updated on 2022/04/04

写真a

 
BANNO, Ryoichi
 
Organization
Research Center of Health, Physical Fitness and Sports Division of Health Science Associate professor
Graduate School
Graduate School of Medicine
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 博士(医学) ( 2005.3   名古屋大学 ) 

Research Interests 2

  1. 糖尿病

  2. 肥満

Research Areas 1

  1. Others / Others  / Metabolism Studies

Current Research Project and SDGs 2

  1. 糖・エネルギー代謝調節機構の解明

  2. レプチン受容体シグナルを介した1型糖尿病の新規治療開発

Research History 11

  1. 名古屋大学総合保健体育科学センター   保健科学部   准教授

    2018.4

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    Country:Japan

  2. 名古屋大学大学院医学系研究科   糖尿病・内分泌内科   講師

    2017.4 - 2018.3

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    Country:Japan

  3. 名古屋大学医学部附属病院   糖尿病・内分泌内科   講師

    2015.11 - 2017.3

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    Country:Japan

  4. 名古屋大学医学部附属病院   糖尿病・内分泌内科   助教

    2011.7 - 2015.10

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    Country:Japan

  5. 名古屋大学医学部附属病院   糖尿病・内分泌内科   病院助教

    2011.1 - 2011.6

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    Country:Japan

  6. 名古屋大学医学部附属病院   糖尿病・内分泌内科   医員

    2010.4 - 2010.12

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    Country:Japan

  7. 名古屋大学医学部附属病院   糖尿病・内分泌内科   客員研究者

    2009.4 - 2010.3

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    Country:Japan

  8. ペンシルバニア大学   研究員

    2006.4 - 2009.3

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    Country:Japan

  9. 静岡済生会総合病院   内分泌内科

    2001.4 - 2002.3

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    Country:Japan

  10. 名古屋第二赤十字病院   内分泌内科

    2000.4 - 2001.3

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    Country:Japan

  11. 名古屋第二赤十字病院    研修医

    1998.5 - 2000.3

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    Country:Japan

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Education 3

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2005.3

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    Country: Japan

  2. Shinshu University   Faculty of Medicine

    - 1998.3

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    Country: Japan

  3. Tokyo University of Science   Faculty of Science and Engineering

    - 1992.3

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    Country: Japan

Professional Memberships 9

  1. 日本肥満学会

  2. 日本神経内分泌学会

  3. 日本糖尿病学会

  4. 日本内分泌学会

  5. 日本甲状腺学会

  6. 日本内科学会

  7. Society for Neuroscience

  8. The Eondocrine Society

  9. 北米肥満学会

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Committee Memberships 2

  1. 日本肥満学会 国際委員会   委員  

    2017.11 - 2021.12   

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    Committee type:Academic society

  2. 日本肥満学会 国際委員会   委員  

    2017.11 - 2020.11   

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    Committee type:Academic society

 

Papers 76

  1. Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline.

    Iwama S, Kobayashi T, Yasuda Y, Okuji T, Ito M, Ando M, Zhou X, Yamagami A, Onoue T, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Hase T, Morise M, Wakahara K, Yokota K, Kato M, Nishio N, Tanaka C, Miyata K, Ogura A, Ito T, Sawada T, Shimokata T, Niimi K, Ohka F, Ishigami M, Gotoh M, Hashimoto N, Saito R, Kiyoi H, Kajiyama H, Ando Y, Hibi H, Sone M, Akiyama M, Kodera Y, Arima H

    The Journal of clinical endocrinology and metabolism   Vol. 107 ( 4 ) page: e1620 - e1630   2022.3

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    Language:English  

    DOI: 10.1210/clinem/dgab829

    PubMed

  2. d-Allulose Improves Endurance and Recovery from Exhaustion in Male C57BL/6J Mice

    Liu Bingyang, Gou Yang, Tsuzuki Takamasa, Yamada Takako, Iida Tetsuo, Wang Sixian, Banno Ryoichi, Toyoda Yukiyasu, Koike Teruhiko

    NUTRIENTS   Vol. 14 ( 3 )   2022.2

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  3. Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults. Reply to Sugiyama K and Saisho Y [letter]

    Wada Eri, Onoue Takeshi, Kinoshita Tamaki, Hayase Ayaka, Handa Tomoko, Ito Masaaki, Furukawa Mariko, Okuji Takayuki, Kobayashi Tomoko, Iwama Shintaro, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Goto Motomitsu, Arima Hiroshi

    DIABETOLOGIA   Vol. 65 ( 1 ) page: 252 - 253   2022.1

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  4. Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis

    Ryuge Akihiro, Kosugi Tomoki, Maeda Kayaho, Banno Ryoichi, Gou Yang, Zaitsu Kei, Ito Takanori, Sato Yuka, Hirayama Akiyoshi, Tsubota Shoma, Honda Takashi, Nakajima Kazuki, Ozaki Tomoya, Kondoh Kunio, Takahashi Kazuo, Kato Noritoshi, Ishimoto Takuji, Soga Tomoyoshi, Nakagawa Takahiko, Koike Teruhiko, Arima Hiroshi, Yuzawa Yukio, Minokoshi Yasuhiko, Maruyama Shoichi, Kadomatsu Kenji

    JCI INSIGHT   Vol. 6 ( 20 )   2021.10

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  5. Adult-onset autoimmune diabetes identified by glutamic acid decarboxylase autoantibodies: a retrospective cohort study

    Wada Eri, Onoue Takeshi, Kinoshita Tamaki, Hayase Ayaka, Handa Tomoko, Ito Masaaki, Furukawa Mariko, Okuji Takayuki, Kobayashi Tomoko, Iwama Shintaro, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Goto Motomitsu, Arima Hiroshi

    DIABETOLOGIA   Vol. 64 ( 10 ) page: 2183 - 2192   2021.10

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  6. d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats

    Gou Yang, Liu Bingyang, Cheng Mengyao, Yamada Takako, Iida Tetsuo, Wang Sixian, Banno Ryoichi, Koike Teruhiko

    MOLECULES   Vol. 26 ( 20 )   2021.10

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  7. GABA(B) receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice

    Sun Runan, Tsunekawa Taku, Hirose Tomonori, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Bettler Bernhard, Arima Hiroshi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 19296   2021.9

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  8. Deficiency of WFS1 leads to the impairment of AVP secretion under dehydration in male mice

    Kurimoto Junki, Takagi Hiroshi, Miyata Takashi, Hodai Yuichi, Kawaguchi Yohei, Hagiwara Daisuke, Suga Hidetaka, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Ito Yoshihiro, Iwama Shintaro, Banno Ryoichi, Tanabe Katsuya, Tanizawa Yukio, Arima Hiroshi

    PITUITARY   Vol. 24 ( 4 ) page: 582 - 588   2021.8

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  9. Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice

    Mizoguchi Akira, Banno Ryoichi, Sun Runan, Yaginuma Hiroshi, Taki Keigo, Kobayashi Tomoko, Sugiyama Mariko, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Nagai Taku, Yamada Kiyofumi, Arima Hiroshi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 12873   2021.6

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  10. CD4(+) T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice

    Yasuda Yoshinori, Iwama Shintaro, Sugiyama Daisuke, Okuji Takayuki, Kobayashi Tomoko, Ito Masaaki, Okada Norio, Enomoto Atsushi, Ito Sachiko, Yan Yue, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Takagi Hiroshi, Hagiwara Daisuke, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Takahashi Masahide, Nishikawa Hiroyoshi, Arima Hiroshi

    SCIENCE TRANSLATIONAL MEDICINE   Vol. 13 ( 593 )   2021.5

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  11. High-fat feeding causes inflammation and insulin resistance in the ventral tegmental area in mice Reviewed

    Akira Mizoguchi, Ryoichi Banno, Runan Sun, Hiroshi Yaginuma, Keigo Taki, Tomoko Kobayashi, Mariko Sugiyama, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Hidetaka Suga, Hiroshi Arima

    Neuroscience   Vol. 461   page: 72 - 79   2021.5

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  12. Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors

    Kobayashi Tomoko, Iwama Shintaro, Sugiyama Daisuke, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Ito Sachiko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Nishikawa Hiroyoshi, Arima Hiroshi

    JOURNAL FOR IMMUNOTHERAPY OF CANCER   Vol. 9 ( 5 )   2021.5

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  13. Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons

    Hagiwara Daisuke, Tochiya Masayoshi, Azuma Yoshinori, Tsumura Tetsuro, Hodai Yuichi, Kawaguchi Yohei, Miyata Takashi, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Arima Hiroshi

    PEPTIDES   Vol. 139   page: 170517   2021.5

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  14. Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet. Reviewed

    Taki K, Takagi H, Hirose T, Sun R, Yaginuma H, Mizoguchi A, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Iwama S, Suga H, Banno R, Sakano D, Kume S, Arima H.

    PLoS One.     2021.3

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    DOI: 10.1371/journal.pone.0248065.

  15. Dietary sodium chloride attenuates increased beta-cell mass to cause glucose intolerance in mice under a high-fat diet

    Taki Keigo, Takagi Hiroshi, Hirose Tomonori, Sun Runan, Yaginuma Hiroshi, Mizoguchi Akira, Kobayashi Tomoko, Sugiyama Mariko, Tsunekawa Taku, Onoue Takeshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Sakano Daisuke, Kume Shoen, Arima Hiroshi

    PLOS ONE   Vol. 16 ( 3 ) page: e0248065   2021.3

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  16. Deficiency of WFS1 leads to the impairment of AVP secretion under dehydration in male mice. Reviewed

    Kurimoto J, Takagi H, Miyata T, Hodai Y, Kawaguchi Y, Hagiwara D, Suga H, Kobayashi T, Sugiyama M, Onoue T, Ito Y, Iwama S, Banno R, Tanabe K, Tanizawa Y, Arima H.

    Pituitary     2021.3

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    DOI: 10.1007/s11102-021-01135-6.

  17. Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons. Reviewed

    Hagiwara D, Tochiya M, Azuma Y, Tsumura T, Hodai Y, Kawaguchi Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Ito Y, Iwama S, Suga H, Banno R, Arima H.

    Peptides     2021.2

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    DOI: 10.1016/j.peptides.2021.170517.

  18. Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice

    Yaginuma Hiroshi, Banno Ryoichi, Sun Runan, Taki Keigo, Mizoguchi Akira, Kobayashi Tomoko, Sugiyama Mariko, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Arima Hiroshi

    JOURNAL OF PHARMACOLOGICAL SCIENCES   Vol. 147 ( 4 ) page: 340 - 347   2021

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  19. Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice Reviewed

    Kawaguchi Yohei, Hagiwara Daisuke, Miyata Takashi, Hodai Yuichi, Kurimoto Junki, Takagi Hiroshi, Suga Hidetaka, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Ito Yoshihiro, Iwama Shintaro, Banno Ryoichi, Grinevich Valery, Arima Hiroshi

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 19730   2020.11

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  20. Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons Reviewed

    Miyata Takashi, Hagiwara Daisuke, Hodai Yuichi, Miwata Tsutomu, Kawaguchi Yohei, Kurimoto Junki, Ozaki Hajime, Mitsumoto Kazuki, Takagi Hiroshi, Suga Hidetaka, Kobayashi Tomoko, Sugiyama Mariko, Onoue Takeshi, Ito Yoshihiro, Iwama Shintaro, Banno Ryoichi, Matsumoto Mami, Kawakami Natsuko, Ohno Nobuhiko, Sakamoto Hirotaka, Arima Hiroshi

    ISCIENCE   Vol. 23 ( 10 ) page: 101648   2020.10

  21. Peripheral combination treatment of leptin and SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mice

    Yaginuma H., Banno R., Sun R., Taki K., Sugiyama M., Tsunekawa T., Takagi H., Ito Y., Arima H.

    DIABETOLOGIA   Vol. 63 ( SUPPL 1 ) page: S259 - S260   2020.9

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  22. The regulation of glucose metabolism by astrocytes in diet induced obesity mice

    Sugiyama M., Banno R., Sun R., Yaginuma H., Taki K., Takagi H., Ito Y., Yamanaka K., Arima H.

    DIABETOLOGIA   Vol. 63 ( SUPPL 1 ) page: S266 - S266   2020.9

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  23. Protein tyrosine phosphatase 1B deficiency enhances leptin action to improve glucose homeostasis in IDDM treatment with leptin

    Ito Y., Banno R., Sun R., Yaginuma H., Taki K., Sugiyama M., Tsunekawa T., Takagi H., Arima H.

    DIABETOLOGIA   Vol. 63 ( SUPPL 1 ) page: S12 - S12   2020.9

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  24. Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study Reviewed

    Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Okuji Takayuki, Ito Masaaki, Onoue Takeshi, Goto Motomitsu, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Fujimoto Yasushi, Hibi Hideharu, Sone Michihiko, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

    JOURNAL FOR IMMUNOTHERAPY OF CANCER   Vol. 8 ( 2 )   2020.7

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    DOI: 10.1136/jitc-2020-000779

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  25. Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions Reviewed

    Sugiyama Mariko, Banno Ryoichi, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Komine Okiru, Yamanaka Koji, Arima Hiroshi

    NEUROCHEMISTRY INTERNATIONAL   Vol. 136   page: 104733   2020.6

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    DOI: 10.1016/j.neuint.2020.104733

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  26. Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study Reviewed

    Okada Norio, Iwama Shintaro, Okuji Takayuki, Kobayashi Tomoko, Yasuda Yoshinori, Wada Eri, Onoue Takeshi, Goto Motomitsu, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Kanda Mitsuro, Yokota Kenji, Hashimoto Naozumi, Ando Masahiko, Fujimoto Yasushi, Nagino Masato, Kodera Yasuhiro, Fujishiro Mitsuhiro, Hibi Hideharu, Sone Michihiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

    BRITISH JOURNAL OF CANCER   Vol. 122 ( 6 ) page: 771 - 777   2020.3

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    DOI: 10.1038/s41416-020-0736-7

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  27. Dipeptidyl peptidase-4 inhibitor anagliptin reduces fasting apolipoprotein B-48 levels in patients with type 2 diabetes: A randomized controlled Reviewed

    Onoue Takeshi, Goto Motomitsu, Wada Eri, Furukawa Mariko, Okuji Takayuki, Okada Norio, Kobayashi Tomoko, Iwama Shintaro, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Seino Yusuke, Suga Hidetaka, Banno Ryoichi, Hamada Yoji, Ando Masahiko, Yamamori Etsuko, Arima Hiroshi

    PLOS ONE   Vol. 15 ( 1 ) page: e0228004   2020.1

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    DOI: 10.1371/journal.pone.0228004

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  28. Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells Reviewed

    Kasai Takatoshi, Suga Hidetaka, Sakakibara Mayu, Ozone Chikafumi, Matsumoto Ryusaku, Kano Mayuko, Mitsumoto Kazuki, Ogawa Koichiro, Kodani Yu, Nagasaki Hiroshi, Inoshita Naoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Takagi Hiroshi, Hagiwara Daisuke, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Takahashi Jun, Arima Hiroshi

    CELL REPORTS   Vol. 30 ( 1 ) page: 18 - +   2020.1

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    DOI: 10.1016/j.celrep.2019.12.009

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  29. Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial Reviewed

    Wada Eri, Onoue Takeshi, Kobayashi Tomoko, Handa Tomoko, Hayase Ayaka, Ito Masaaki, Furukawa Mariko, Okuji Takayuki, Okada Norio, Iwama Shintaro, Sugiyama Mariko, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Banno Ryoichi, Kuwatsuka Yachiyo, Ando Masahiko, Goto Motomitsu, Arima Hiroshi

    BMJ OPEN DIABETES RESEARCH & CARE   Vol. 8 ( 1 )   2020.1

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    DOI: 10.1136/bmjdrc-2019-001115

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  30. Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion Reviewed

    Takagi Hiroshi, Hagiwara Daisuke, Handa Tomoko, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Takahashi Kunihiko, Matsui Shigeyuki, Arima Hiroshi

    ENDOCRINE JOURNAL   Vol. 67 ( 3 ) page: 267 - 274   2020

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    DOI: 10.1507/endocrj.EJ19-0224

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  31. GABA(B) Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet Reviewed

    Tsunekawa Taku, Banno Ryoichi, Yaginuma Hiroshi, Taki Keigo, Mizoguchi Akira, Sugiyama Mariko, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Bettler Bernhard, Arima Hiroshi

    ISCIENCE   Vol. 20   page: 337-+   2019.10

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    DOI: 10.1016/j.isci.2019.09.032

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  32. Improved methods for the differentiation of hypothalamic vasopressin neurons using mouse induced pluripotent stem cells Reviewed

    Mitsumoto Kazuki, Suga Hidetaka, Sakakibara Mayu, Soen Mika, Yamada Tomiko, Ozaki Hajime, Nagai Takashi, Kano Mayuko, Kasai Takatoshi, Ozone Chikafumi, Ogawa Koichiro, Sugiyama Mariko, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Arima Hiroshi

    STEM CELL RESEARCH   Vol. 40   page: 101572   2019.10

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    DOI: 10.1016/j.scr.2019.101572

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  33. Tanycyte-Like Cells Derived From Mouse Embryonic Stem Culture Show Hypothalamic Neural Stem/Progenitor Cell Functions. Reviewed

    Kano M, Suga H, Ishihara T, Sakakibara M, Soen M, Yamada T, Ozaki H, Mitsumoto K, Kasai T, Sugiyama M, Onoue T, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Iwama S, Goto M, Banno R, Arima H

    Endocrinology   Vol. 160 ( 7 ) page: 1701-1718   2019.7

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    DOI: 10.1210/en.2019-00105

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  34. Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus Reviewed

    Tochiya Masayoshi, Hagiwara Daisuke, Azuma Yoshinori, Miyata Takashi, Morishita Yoshiaki, Suga Hidetaka, Onoue Takeshi, Tsunekawa Taku, Takagi Hiroshi, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Banno Ryoichi, Arima Hiroshi

    NEUROSCIENCE LETTERS   Vol. 682   page: 50-55   2018.8

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    DOI: 10.1016/j.neulet.2018.06.013

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  35. Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis Reviewed

    Yasuda Yoshinori, Iwama Shintaro, Kiyota Atsushi, Izumida Hisakazu, Nakashima Kohtaro, Iwata Naoko, Ito Yoshihiro, Morishita Yoshiaki, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Enomoto Atsushi, Takahashi Masahide, Arima Hiroshi, Sugimura Yoshihisa

    JOURNAL OF PATHOLOGY   Vol. 244 ( 4 ) page: 469-478   2018.4

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    DOI: 10.1002/path.5046

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  36. Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study Reviewed

    Kobayashi Tomoko, Iwama Shintaro, Yasuda Yoshinori, Okada Norio, Tsunekawa Taku, Onoue Takeshi, Takagi Hiroshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Goto Motomitsu, Suga Hidetaka, Banno Ryoichi, Yokota Kenji, Hase Tetsunari, Morise Masahiro, Hashimoto Naozumi, Ando Masahiko, Kiyoi Hitoshi, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Arima Hiroshi

    JOURNAL OF THE ENDOCRINE SOCIETY   Vol. 2 ( 3 ) page: 241-251   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/js.2017-00432

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  37. Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors Reviewed

    Ogawa Koichiro, Suga Hidetaka, Ozone Chikafumi, Sakakibara Mayu, Yamada Tomiko, Kano Mayuko, Mitsumoto Kazuki, Kasai Takatoshi, Kodani Yu, Nagasaki Hiroshi, Yamamoto Naoki, Hagiwara Daisuke, Goto Motomitsu, Banno Ryoichi, Sugimura Yoshihisa, Arima Hiroshi

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 3615   2018.2

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    DOI: 10.1038/s41598-018-22053-x

    Web of Science

    PubMed

  38. Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors. Reviewed

    Ogawa K, Suga H, Ozone C, Sakakibara M, Yamada T, Kano M, Mitsumoto K, Kasai T, Kodani Y, Nagasaki H, Yamamoto N, Hagiwara D, Goto M, Banno R, Sugimura Y, Arima H.

    Sci Rep.   Vol. 8 ( 1 ) page: 3615   2018.2

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  39. Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study. Reviewed

    Kobayashi T, Iwama S, Yasuda Y, Okada N, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Morishita Y, Goto M, Suga H, Banno R, Yokota K, Hase T, Morise M, Hashimoto N, Ando M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H.

    J Endocr Soc.   Vol. 2 ( 3 ) page: 241-251   2018.2

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  40. Sequestosome 1 (SQSTMI/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture Reviewed

    Tominaga Takashi, Goto Motomitsu, Onoue Takeshi, Mizoguchi Akira, Sugiyama Mariko, Tsunekawa Taku, Hagiwara Daisuke, Morishita Yoshiaki, Ito Yoshihiro, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Arima Hiroshi

    NEUROSCIENCE LETTERS   Vol. 656   page: 103-107   2017.8

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    DOI: 10.1016/j.neulet.2017.06.014

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  41. PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions

    Sugiyama Mariko, Banno Ryoichi, Mizoguchi Akira, Tominaga Takashi, Tsunekawa Taku, Onoue Takeshi, Hagiwara Daisuke, Ito Yoshihiro, Morishita Yoshiaki, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Arima Hiroshi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 488 ( 1 ) page: 116-121   2017.6

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    DOI: 10.1016/j.bbrc.2017.05.019

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    PubMed

  42. Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis

    Iwata Naoko, Iwama Shintaro, Sugimura Yoshihisa, Yasuda Yoshinori, Nakashima Kohtaro, Takeuchi Seiji, Hagiwara Daisuke, Ito Yoshihiro, Suga Hidetaka, Goto Motomitsu, Banno Ryoichi, Caturegli Patrizio, Koike Teruhiko, Oshida Yoshiharu, Arima Hiroshi

    PITUITARY   Vol. 20 ( 3 ) page: 301-310   2017.6

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    DOI: 10.1007/s11102-016-0780-8

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  43. Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia Reviewed

    Tsunekawa Taku, Banno Ryoichi, Mizoguchi Akira, Sugiyama Mariko, Tominaga Takashi, Onoue Takeshi, Hagiwara Daisuke, Ito Yoshihiro, Iwama Shintaro, Goto Motomitsu, Suga Hidetaka, Sugimura Yoshihisa, Arima Hiroshi

    EBIOMEDICINE   Vol. 16   page: 172-183   2017.2

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    DOI: 10.1016/j.ebiom.2017.01.007

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    PubMed

  44. Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis. Reviewed

    Iwata N, Iwama S, Sugimura Y, Yasuda Y, Nakashima K, Takeuchi S, Hagiwara D, Ito Y, Suga H, Goto M, Banno R, Caturegli P, Koike T, Oshida Y, Arima H.

    Pituitary   Vol. 20 ( 3 ) page: 301-310   2016.11

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    DOI: 10.1007/s11102-016-0780-8.

  45. Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. Reviewed

    Ji S, Tokizane K, Ohkawa Y, Ohmi Y, Banno R, Okajima T, Kiyama H, Furukawa K, Furukawa K.

    Biochem Biophys Res Commun.   Vol. 479 ( 3 ) page: 453-460   2016.10

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    DOI: 10.1016/j.bbrc.2016.09.077.

  46. Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus. Reviewed

    Onoue T, Goto M, Tominaga T, Sugiyama M, Tsunekawa T, Hagiwara D, Banno R, Suga H, Sugimura Y, Arima H.

    Neuroscience Letters   Vol. 619   page: 1-7   2016.4

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    DOI: 10.1016/j.neulet.2016.03.011.

  47. AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat Diet. Reviewed

    Shibata M, Banno R, Sugiyama M, Tominaga T, Onoue T, Tsunekawa T, Azuma Y, Hagiwara D, Lu W, Ito Y, Goto M, Suga H, Sugimura Y, Oiso Y, Arima H.

    Endocrinology   Vol. 157 ( 4 ) page: 1457-1466   2016.2

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    DOI: 10.1210/en.2015-1430

  48. Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice. Reviewed

    Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Arima H.

    Neurosci Lett.   Vol. 612   page: 199-203   2016.1

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  49. BMP4 and FGF strongly induce differentiation of mouse ES cells into oral ectoderm. Reviewed

    Ochiai H, Suga H, Yamada T, Sakakibara M, Kasai T, Ozone C, Ogawa K, Goto M, Banno R, Tsunekawa S, Sugimura Y, Arima H, Oiso Y

    Stem Cell Res.   Vol. 15 ( 2 ) page: 290-8   2015.7

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    DOI: 10.1016/j.scr.2015.06.011

  50. b-Series gangliosides crucially regulate leptin secretion in adipose tissues Reviewed

    Ji S, Ohkawa Y, Tokizane K, Ohmi Y, Banno R, Furukawa K, Kiyama H, Furukawa K

    Biochem Biophys Res Commun   Vol. 459 ( 2 ) page: 189-95   2015.4

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    DOI: 10.1016/j.bbrc.2015.01.143.

  51. Activating Transcription Factor 6α Is Required for the Vasopressin Neuron System to Maintain Water Balance under Dehydration in Male Mice. Reviewed

    Azuma Y, Hagiwara D, Lu W, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Shiota A, Asai N, Takahashi M, Oiso Y, Arima H.

    Endocrinology     2014.9

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  52. Mitogen-activated protein kinase phosphatase 1 negatively regulates MAPK signaling in mouse hypothalamus. Reviewed

    Adachi K, Goto M, Onoue T, Tsunekawa T, Shibata M, Hagimoto S, Ito Y, Banno R, Suga H, Sugimura Y, Oiso Y, Arima H.

    Neurosci Lett.   Vol. 569   page: 49-54   2014.5

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  53. Minocycline prevents osmotic demyelination associated with aquaresis. Reviewed

    Takagi H, Sugimura Y, Suzuki H, Iwama S, Izumida H, Fujisawa H, Ogawa K, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Suga H, Goto M, Banno R, Arima H, Oiso Y.

    Kidney Int.   Vol. 86 ( 5 ) page: 954-64   2014.4

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  54. Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus. Reviewed

    Hagiwara D, Arima H, Morishita Y, Wenjun L, Azuma Y, Ito Y, Suga H, Goto M, Banno R, Sugimura Y, Shiota A, Asai N, Takahashi M, Oiso Y.

    Cell Death Dis.   Vol. 5 ( e1148 )   2014.3

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    DOI: 10.1038/cddis.2014.124.

  55. GABA Type B Receptor Signaling in Proopiomelanocortin Neurons Protects Against Obesity, Insulin Resistance, and Hypothalamic Inflammation in Male Mice on a High-Fat Diet. Reviewed

    Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Hagiwara D, Ozawa Y, Goto M, Suga H, Sugimura Y, Bettler B, Oiso Y, Arima H.

    J Neurosci.   Vol. 33 ( 43 ) page: 17166-17173   2013.10

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    DOI: 10.1523/JNEUROSCI.0897-13.2013.

  56. Expression of neuropeptide Y and agouti-related protein mRNA stimulated by glucocorticoids is attenuated via NF-κB p65 under ER stress in mouse hypothalamic cultures. Reviewed

    Hagimoto S, Arima H, Adachi K, Ito Y, Suga H, Sugimura Y, Goto M, Banno R, Oiso Y.

    Neurosci Lett.   Vol. 11 ( 553 ) page: 165-169   2013.8

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    DOI: 10.1016/j.neulet.2013.08.040.

  57. Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide Y gene in rats. Reviewed

    Ozawa Y, Arima H, Banno R, Ito Y, Goto M, Morishita Y, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y.

    Neuroreport.   Vol. 1 ( 23 ) page: 673-5   2012.8

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  58. BiP mRNA expression is upregulated by dehydration in vasopressin neurons in the hypothalamus in mice. Reviewed

    Hagiwara D, Arima H, Morishita Y, Goto M, Banno R, Sugimura Y, Oiso Y.

    Peptides.   Vol. 33 ( 2 ) page: 346-50   2012.1

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  59. TNFα increases hypothalamic PTP1B activity via the NFκB pathway in rat hypothalamic organotypic cultures. Reviewed

    Ito Y, Banno R, Hagimoto S, Ozawa Y, Arima H, Oiso Y.

    Regul Pept.   Vol. 10 ( 174 ) page: 58-64   2011.12

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  60. Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. Reviewed

    De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK

    Am J Physiol Endocrinol Metab.   Vol. 300 ( 6 ) page: 1002-1011   2011.6

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  61. Repeated glucoprivation delayed hyperphagic responses while activating neuropeptide Y neurons in rats. Reviewed

    Ozawa Y, Arima H, Watanabe M, Shimizu H, Ito Y, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y

    Peptides   Vol. 32 ( 4 ) page: 763-769   2011.4

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  62. PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. Reviewed

    Banno R, Zimmer D, De Jonghe BC, Atienza M, Rak K, Yang WT, Bence KK

    J Clin Invest.   Vol. 120 ( 3 ) page: 720-734   2010.3

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  63. Glucocorticoids increase NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Reviewed

    Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y

    Peptides.   Vol. 31 ( 1 ) page: 145-149   2010.1

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  64. The medial hypothalamus is required for the feeding response to glucoprivation but not to food deprivation. Reviewed

    Watanabe M, Arima H, Ozawa Y, Goto M, Shimizu H, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y

    Neurosci Lett.   Vol. 464 ( 1 ) page: 6-9   2009.10

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  65. Direct and indirect modulation of neuropeptide Y gene expression in response to hypoglycemia in rat arcuate nucleus. Reviewed

    Watanabe M, Arima H, Fukushima K, Goto M, Shimizu H, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y

    FEBS Lett.   Vol. 582   page: 3632-3638   2008.10

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  66. Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats. Reviewed

    Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y

    Endocrinology.   Vol. 149 ( 9 ) page: 4544-4553   2008.9

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  67. Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice. Reviewed

    Sato I, Arima H, Ozaki N, Ozaki N, Watanabe M, Goto M, Shimizu H, Hayashi M, Banno R, Nagasaki H, Oiso Y

    FEBS Lett.   Vol. 581 ( 25 ) page: 4857-4864   2007.10

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  68. Insulin is not a prerequisite for rapid regulation of neuropeptide Y gene transcription in the arcuate nucleus in food-restricted rats. Reviewed

    Goto M, Arima H, Hiroi M, Shimizu H, Watanabe M, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y

    Neurosci Lett.   Vol. 420 ( 1 ) page: 61-65   2007.6

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  69. Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats. Reviewed

    Banno R, Arima H, Hayashi M, Goto M, Watanabe M, Sato I, Ozaki N, Nagasaki H, Ozaki N, Oiso Y

    FEBS Lett.   Vol. 581 ( 6 ) page: 1131-1136   2007.3

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  70. Ghrelin increases neuropeptide Y and agouti-related peptide gene expression in the arcuate nucleus in rat hypothalamic organotypic cultures. Reviewed

    Goto M, Arima H, Watanabe M, Hayashi M, Banno R, Sato I, Nagasaki H, Oiso Y

    Endocrinology.   Vol. 147 ( 11 ) page: 5102-5109   2006.11

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  71. Vasopressin gene transcription increases in response to decreases in plasma volume, but not to increases in plasma osmolality, in chronically dehydrated rats. Reviewed

    Hayashi M, Arima H, Goto M, Banno R, Watanabe M, Sato I, Nagasaki H, Oiso Y

    Am J Physiol Endocrinol Metab.   Vol. 290 ( 2 ) page: 213-217   2006.2

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  72. Insulin inhibits neuropeptide Y gene expression in the arcuate nucleus through GABAergic systems. Reviewed

    Sato I, Arima H, Ozaki N, Watanabe M, Goto M, Hayashi M, Banno R, Nagasaki H, Oiso Y

    J Neurosci.   Vol. 25 ( 38 ) page: 8657-8664   2005.9

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  73. The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Reviewed

    Banno R, Arima H, Sato I, Hayashi M, Goto M, Sugimura Y, Murase T, Oiso Y

    Peptides.   Vol. 25 ( 8 ) page: 1279-1286   2004.8

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  74. Leukemia inhibitory factor stimulates vasopressin release in rats. Reviewed

    Ishizaki S, Murase T, Sugimura Y, Banno R, Arima H, Miura Y, Oiso Y

    Neurosci Lett.   Vol. 359   page: 77-80   2004.4

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  75. Osmoregulation of vasopressin release and gene transcription under acute and chronic hypovolemia in rats. Reviewed

    Kondo N, Arima H, Banno R, Kuwahara S, Sato I, Oiso Y

    Am J Physiol Endocrinol Metab.   Vol. 286 ( 3 ) page: 337-346   2004.3

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  76. Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures. Reviewed

    Kuwahara S, Arima H, Banno R, Sato I, Kondo N, Oiso Y

    J Neurosci.   Vol. 23 ( 32 ) page: 10231-10237   2003.11

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▼display all

Books 3

  1. The role of PTP1B in the reward system

    Banno Ryoichi( Role: Sole author)

    2022.1 

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    Responsible for pages:4   Language:Japanese

  2. 糖・エネルギー代謝調節におけるPTP1Bの役割について

    坂野僚一, 杉山摩利子, 恒川 卓, 伊藤禎浩, 有馬 寛( Role: Joint author)

    科学評論社  2020.7 

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    Total pages:6   Responsible for pages:6   Language:Japanese

  3. レプチン抵抗性

    坂野僚一( Role: Sole author)

    メディカルレビュー社  2016.1 

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    Language:Japanese

Presentations 40

  1. レプチン投与はPTP1B欠損下で インスリン依存性糖尿病モデルマウスの糖代謝を改善する Invited

    坂野僚一

    大学共同利用機関法人 自然科学研究機構 生理学研究所 研究会「運動器/代謝系連関による生体機能制御とその変容の仕組み」  2021.12.19  自然科学研究機構 生理学研究所

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    Event date: 2021.12

    Language:Japanese  

    Venue:愛知県岡崎市  

  2. PTP1B in Ventral Tegmental Area Neurons Increases the Rewarding Value of a High-Fat Diet in Mice International conference

    Banno R, Wang S, Gou Y, Liu B, Sun R, Sasaki T, Hirose T, Sugiyama M, Arima H, and Koike T

    ObesityWeek  2021.11  THE OBESITY SOCIETY

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    Event date: 2021.11

    Language:English   Presentation type:Poster presentation  

    Venue:Dallas   Country:United States  

  3. Inflammation in the ventral tegmental area by HFD increases refeeding consumption after fasting. International conference

    Sun R, Sugiyama M, Sasaki T, Hirose T, Tsunekawa T, Takagi H, Banno R, and Arima H

    ObesityWeek  2021.11  THE OBESITY SOCIETY

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    Event date: 2021.11

    Language:English  

    Venue:Dallas   Country:United States  

  4. 食塩と脂質の過剰摂取が体重、糖代謝に与える影響

    高木博史, 滝 啓吾, 坂野僚一, 有馬 寛

    2020年度生理学研究会「運動器/代謝系連関による生体機能制御とその変容の仕組み」  2020.12.20  生理学研究所

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    Event date: 2020.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡崎市 愛知県  

  5. インスリン依存性糖尿病モデルマウスの糖代謝はインスリン非投与下でレプチンおよびSGLT2阻害剤の併用投与により改善する

    柳沼裕史, 坂野僚一, 孫 汝楠, 滝 啓吾, 杉山摩利子, 恒川 卓, 髙木博史, 伊藤禎浩, 有馬 寛

    第63回日本糖尿病学会年次学術集会  2020.10  日本糖尿病学会

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    Event date: 2020.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大津市  

  6. Protein tyrosine phosphatase 1B deficiency enhances leptin action to improve glucose homeostasis in IDDM treatment with leptin. International conference

    Y. Ito, R. Banno, R. Sun, H. Yaginuma, K. Taki, M. Sugiyama, H. Takagi, and H. Arima.

    EASD Annual Meeting 2020  2020.9.22  欧州糖尿病学会

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    Event date: 2020.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:オーストリア ウイーン  

  7. Peripheral combination treatment of leptin and SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice. International conference

    H. Yaginuma, R. Banno, R. Sun, K. Taki, M. Sugiyama, T. Tsunekawa, H. Takagi, Y. Ito, and H. Arima

    EASD Annual Meeting 2020  2020.9.23 

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    Event date: 2020.9

    Language:English   Presentation type:Poster presentation  

  8. The regulation of glucose metabolism by astrocytes in diet induced obesity mice International conference

    M. Sugiyama, R. Banno, R. Sun, H. Yaginuma, K. Taki, H. Takagi, Y. Ito, K. Yamanaka, and Arima H

    EASD Annual Meeting 2020  2020.9.24 

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    Event date: 2020.9

    Language:English   Presentation type:Poster presentation  

  9. インスリンを使用することなく血糖値を正常化する治療法 Invited

    坂野僚一

    日本IDDMネットワークサイエンスフォーラム  2020.9  認定特定非営利活動法人 日本IDDMネットワーク

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    Event date: 2020.9

    Language:Japanese  

    Venue:東京  

  10. タモキシフェン誘導性Creマウスを用いたアストロサイト特異的PTP1B欠損マウスの表現型解析

    杉山摩利子, 坂野僚一, 孫 汝楠, 柳沼裕史, 滝 啓吾, 恒川 卓, 髙木博史, 伊藤禎浩, 有馬 寛

    第93回日本内分泌学会学術総会   2020.8  日本内分泌学会

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    Event date: 2020.7 - 2020.8

    Language:Japanese   Presentation type:Poster presentation  

    Venue:浜松市  

  11. GABAB receptor signaling in striatal neurons suppresses binge-like eating of a high fat diet in mice International conference

    Tsunekawa T, Banno R, Sun R, Yaginuma H, Taki T, Sugiyama M, Takagi H, Ito Y, Arima H

    2019 ObesityWeek  2019.11.5 

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    Event date: 2019.11

    Language:English   Presentation type:Poster presentation  

  12. High-fat feeding causes inflammation and insulin resistance in ventral tegmental area in mice International conference

    Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Sugiyama M, Tsunekawa T, Takagi H, Ito Y, Arima H

    2019 ObesityWeek  2019.11.6 

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    Event date: 2019.11

    Language:English  

  13. Mice lacking PTP1B in astrocyte increases energy expenditure due to enhanced leptin sensitivity International conference

    Sugiyama M, Banno R, Sun R, Yaginuma H, Taki T, Tsunekawa T, Takagi H, Ito Y, Yamanaka K, Arima H

    2019 ObesityWeek  2019.11.6 

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    Event date: 2019.11

    Language:English   Presentation type:Poster presentation  

  14. Baclofenは線条体のドーパミン受容体シグナルを抑制して高脂肪食摂取を抑制する

    恒川卓、坂野僚一、孫汝楠、柳沼裕史、滝啓吾、杉山摩利子、髙木博史、伊藤禎浩、有馬寛

    第40回日本肥満学会  2019.11.3  日本肥満学会

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京  

  15. アストロサイト特異的PTP1B欠損マウスはレプチン感受性およびエネルギー消費が亢進する

    杉山摩利子、坂野僚一、孫汝楠、柳沼裕史、滝啓吾、恒川卓、髙木博史、伊藤禎浩、山中宏二、有馬寛

    第40回日本肥満学会  2019.11.3  日本肥満学会

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    Event date: 2019.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京  

  16. 糖・エネルギー代謝調節におけるPTP1Bの役割について Invited

    坂野僚一

    岡崎生理学研究所 研究会   2019.9.22  生理学研究所

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    Event date: 2019.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:岡崎市 愛知県  

  17. レプチンおよびSGLT2阻害剤の併用投与はインスリン依存性糖尿病モデルマウスの糖代謝を改善する

    柳沼裕史、坂野僚一、滝啓吾、溝口暁、杉山摩利子、恒川卓、髙木博史、伊藤禎浩、有馬寛

    第62回日本糖尿病学会年次学術集会  2019.5.25  日本糖尿病学会

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    Event date: 2019.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:仙台市  

  18. 高脂肪食投与に伴う視床下部弓状核の炎症はアストロサイト特異的PTP1B欠損マウスにおいて減弱する

    杉山摩利子、坂野僚一、柳沼裕史、滝啓吾、溝口暁、恒川卓、髙木博史、伊藤禎浩、山中宏二、有馬寛

    第92回日本内分泌学会学術総会  2019.5.11  日本内分泌学会

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台市  

  19. 中脳腹側被蓋野ドーパミンニューロンにおけるグルココルチコイド受容体シグナルはストレス下において高脂肪食への嗜好形成を増強する

    溝口暁、坂野僚一、柳沼裕史、滝啓吾、杉山摩利子、髙木博史、伊藤禎浩、有馬寛

    第92回日本内分泌学会学術総会  2019.5.10  日本内分泌学会

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    Event date: 2019.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:仙台市  

  20. PTP1B deficiency enhances leptin action to improve glucose homeostasis in IDDM International conference

    Y ITO, R. BANNO, H. YAGINUMA, K. TAKI, A. MIZOGUCHI, M. SUGIYAMA, T. TSUNEKAWA, H. TAKAGI, H. ARIMA

    Neuroscience 2018  2018.11.5  Neuroscience 2018

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  21. High-fat feeding causes microglial activation and inflammation in ventral tegmental area in mice

    Mizoguchi A, Banno R, Yaginuma H, Taki K, Sugiyama M, Tsunekawa T, Takagi H, Ito Y, Arima H

    Neuroscience 2018  2018.11.6 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  22. Mice lacking PTP1B in astrocyte protect against obesity induced by a high fat diet International conference

    Sugiyama M, Banno R, Yaginuma H, Taki T, Mizoguchi A, Tsunekawa T, Takagi H, Ito Y, Yamanaka K, Arima H

    Neuroscience 2018  2018.11.6  Neuroscience 2018

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  23. GABAB receptor signaling in dopaminergic or striatal neurons suppresses food intake during intermittent access to a high fat diet in mice International conference

    T. TSUNEKAWA, R. BANNO, H. YAGINUMA, K. TAKI, A. MIZOGUCHI, M. SUGIYAMA, H. TAKAGI, Y. ITO, H. ARIMA

    Neuroscience 2018  2018.11.4  Neuroscience 2018

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

  24. Analysis of roles of glial cell subtypes in hypothalamic inflammation induced by a high fat diet International conference

    Sugiyama M, Banno R, Taki K, Mizoguchi A, Tsunekawa T, Takagi H, Ito Y, Komine O, Yamanaka K, Arima H

    2017 Obesity Week 

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    Event date: 2017.10 - 2017.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  25. Baclofen suppresses food intake during scheduled feeding on a high fat diet in mice International conference

    Sugiyama M, Banno R, Taki K, Mizoguchi A, Tsunekawa T, Takagi H, Ito Y, Komine O, Yamanaka K, Arima H

    2017 Obesity Week 

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    Event date: 2017.10 - 2017.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  26. PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression with insulin treatment. International conference

    Sugiyama M, Banno R, Mizoguchi A, Tominaga T, Onoue T, Tsunekawa T, Ito Y, Goto M, Arima H

    The Obesity Society's 2016 Annual Meeting 

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    Event date: 2016.10 - 2016.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  27. Deficiency of PTP1B attenuates hypothalamic inflammation induced by high fat diet via the activation of JAK2-STAT3 signaling pathway in the microglial cells International conference

    Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, Ito Y, Goto M, Arima H

    The Obesity Society's 2016 Annual Meeting 

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    Event date: 2016.10 - 2016.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  28. Deficiency of PTP1B attenuates hypothalamic inflammation via the activation of Jak2-Stat3 signaling pathway in the microglial cells under high fat diet conditions International conference

    Banno R, Sugiyama M, Tominaga T, Tsunekawa T, Onoue T, Goto M, Arima H.

    Keystone Symposia 2015 

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  29. Mechanisms by which PTP1B affects energy balance. Invited International conference

    Banno R

    The 46th NIPS International Symposium 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  30. AgRP neuron-specific deletion of glucocorticoid receptor leads to decreased body weight and adiposity in mice. International conference

    Shibata M, Banno R, Onoue T, Tsunekawa T, Adachi K, Ito Y, Goto M, Arima H, Oiso Y

    The joint meeting of International Congress of Endocrinology and Endocrine Society (ICE/ENDO 2014) 

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    Event date: 2014.6

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  31. GABA type B receptor signaling in proopiomelanocortin neurons is protective against obesity, insulin resistance and hypothalamic inflammation in male mice on a high fat diet. International conference

    Banno R, Ito Y, Shibata M, Adachi K, Hagimoto S, Goto M, Bettler B, Oiso Y, Arima H

    The 36th Naito Conference on Molecular Aspects of Energy Balance and Feeding Behavior 

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    Event date: 2013.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  32. POMC neuron-specific deficiency of GABAB receptor leads to obesity on a high fat diet. International conference

    Ito Y, Banno R, Shibata M, Adachi K, Hagimoto S, Goto M, Bettler B, Oiso Y, Arima H

    Neuroscience 2012 

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    Event date: 2012.10

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  33. TNFα increases hypothalamic PTP1B expression via the NFκB pathway in rat hypothalamic organotypic cultures. International conference

    Ito Y, Banno R, Hagimoto S, Ozawa Y, Arima H, Oiso Y

    The Endocrine Society's 93th Annual Meeting 

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    Event date: 2011.6

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  34. Examination of Neuronal PTP1B in Cold-Induced Thermogenesis. International conference

    De Jonghe B, Hayes MR, Banno R, Skibicka K, Zimmer D, Leichner TM, Alhadeff A, Bowen K, Kanoski S, Grill HJ, Bence KK

    28th Annual Scientific Meeting of the Obesity Society 

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    Event date: 2010.10

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  35. Tumor necrosis factor-α increases protein tyrosine phosphatase 1B activity in rat hypothalamic organotypic cultures. International conference

    Ito Y, Banno R, Ozawa Y, Arima H, Oiso Y

    The Endocrine Society's 93th Annual Meeting 

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    Event date: 2010.6

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  36. PTP1B-or SHP2-deficiency in POMC neurons reciprocally regulates energy balance and glucose homeostasis. International conference

    Banno R, Zimmer D, Atienza M, Rak K, Yang WT, Bence KK

    14th International Congress of Endocrinology (ICE2010) 

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    Event date: 2010.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  37. PTP1B-or SHP2-deficiency in POMC Neurons Reciprocally Regulates Body Weight, Glucose Homeostasis, and Hepatic Steatosis. International conference

    Banno R, Zimmer D, Atienza M, Rak K, Yang WT, Bence KK

    27th Annual Scientific Meeting of the Obesity Society 

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    Event date: 2009.10

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  38. Reciprocal regulation of body weight and glucose homeostasis by the protein tyrosine phosphatases PTP1B and SHP2 in POMC neurons. International conference

    Banno R, Zimmer D, Atienza M, Bence KK

    Society for Neuroscience 38th annual meeting 

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    Event date: 2008.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  39. Mice with POMC neuron-specific deletion of protein tyrosine phosphatase 1B (PTP1B) show mild protection from diet-induced obesity and significantly improved glucose homeostasis. International conference

    Banno R, Zimmer D, Atienza M, Bence KK

    Mice with POMC neuron-specific deletion of protein tyrosine phosphatase 1B (PTP1B) show mild protection from diet-induced obesity and significantly improved glucose homeostasis. 

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    Event date: 2008.2

    Language:English   Presentation type:Poster presentation  

    Country:Canada  

  40. Central administration of melanotan II, a melanocortin agonist, decreased the size of adipocyte and increased the serum levels of adiponectin and leptin in diet-induced obesity rats. International conference

    Banno R, Arima H, Goto M, Hayashi M, Watanabe M, Sato I, Oiso Y

    Society for Neuroscience 35th annual meeting 

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    Event date: 2005.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

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KAKENHI (Grants-in-Aid for Scientific Research) 10

  1. 高脂肪食投与下の報酬系におけるプロテインフォスファターゼ1Bの作用解析

    2018.4 - 2021.3

    科学研究費補助金  基盤研究(C)

    坂野僚一

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    Authorship:Principal investigator 

  2. 高脂肪食誘発性の視床下部炎症におけるプロテインフォスファターゼ1Bの作用解析

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  3. 視床下部におけるプロテインタイロシンフォスファターゼ1B発現調節機構の解析

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  4. スポーツ科学の糖尿病運動療法への応用-骨格筋・脳インスリン抵抗性を指標にして

    2020.4 - 2023.3

    科学研究費補助金   基盤研究(C)

    小池晃彦

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    Authorship:Coinvestigator(s) 

    Grant amount:\50000

  5. エネルギーバランスにおける報酬系GABABシステムの機能解析

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  6. NPYニューロンに発現するグルココルチコイドレセプターの機能解析

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  7. スポーツ科学の糖尿病運動療法への応用-骨格筋・脳インスリン抵抗性を指標にして

    Grant number:20K11386  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    小池 晃彦, 都築 孝允, 坂野 僚一

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    Authorship:Coinvestigator(s) 

    運動療法の健康に及ぼす効果は、運動強度や量と必ずしも相関しないことが近年報告されている。申請者らも、レジスタンス運動による筋肥大を、高強度ではなく低強度の有酸素運動が促進することを報告した。本研究では、骨格筋と脳のインスリン抵抗性発現に対する①低強度運動と短時間高強度間欠的運動の抑制効果、②運動実施時間が及ぼす影響、③希少糖プシコースと強制または自発運動の併用による抑制効果を検討する。インスリン抵抗性の改善は、糖尿病のみならず認知症、サルコペニアの予防につながる可能性がある。スポーツ科学の知見を利用し、より実践しやすい運動方法が明らかになれば、運動療法の活用を促進し健康寿命の延伸に貢献できる。
    スポーツ科学の知見を利用し、より実践しやすい運動方法が明らかになれば、運動療法の活用を促進し健康寿命の延伸に貢献できる。また、運動を模倣する効果をもつ栄養素の活用も期待される。私たちの研究室では、糖尿病の主病態であるインスリン抵抗性を指標とし、運動の糖代謝への効果と運動の健康への影響を検討している。本年度は、希少糖アリュロース単独あるいは自発運動(または強制運動)が、骨格筋インスリン抵抗性へ及ぼす効果を2つのモデルで検討した。高脂肪食負荷ラットモデルでは、全身性と筋インスリン抵抗性を、高インスリン正常血糖クランプ法で評価し、希少糖アリュロースが、インスリン抵抗性の抑制作用を持つことを明らかにした。このインスリン抵抗性抑制作用には、高脂肪食負荷による慢性炎症の抑制が関わることを、ELISAと細胞内シグナル経路の解析で示した。また、正常マウスをモデルとした検討においても、アリュロースが単独でインスリン抵抗性を改善することを示すデータを得ている。さらに、自発運動と別のメカニズムで、インスリン抵抗性を改善する可能性が示されている。アリュロースは、肥満症や糖尿病の予防と治療への有効性が期待されている希少糖であるが、運動模倣薬としての可能性もあり、運動による効果との比較、運動との併用効果、その効果のメカニズムについて検討をすすめている。これらは、主に骨格筋を中心とした解析であるが、脳でのインスリン抵抗性についても、高脂肪食モデルでの予備的な検討を行っており、今後、運動の効果をみていく予定である。
    アリュロースのインスリン抵抗性に対する効果は、ほぼ順調に明らかになってきている。アリュロースの運動模倣薬としての可能性についても予備的ではあるが、興味深いデータが得られている。脳でのインスリン抵抗性については、高脂肪食モデルでの脳での炎症性サイトカインの発現、インスリンシグナルの抑制、運動負荷の効果を確認しており、今後は、本課題との関連で詳細に検討をしていく。
    今後は、脳のインスリン抵抗性に及ぼす影響について、研究を進めていきたいと考えている。また、希少糖アリュロース単独あるいは運動との併用のトレーニング効果のメカニズムを明らかにしていく。運動強度あるいは運動方法の工夫についても、検討を進める。

  8. The role of Protein Tyrosine Phosphatase 1B in the reward system under a high fat diet condition

    Grant number:18K08473  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Banno Ryoichi

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    The brain reward system plays an important role in hedonic values of food.The neurons in reward system are regulated by leptin, insulin and inflammation.
    We investigated the effect of protein tyrosine phosphatase-1B (PTP1B), which regulates these three factors, on palatability for a high-fat diet.
    Our data suggested that PTP1B in the dopaminergic neurons in the ventral tegmental area of the midbrain in the reward system contributes to the formation of preference for a high-fat diet.

  9. Analysis of the rewards GABAB system in energy balance

    Grant number:15K09426  2015.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Arima Hiroshi

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    Authorship:Coinvestigator(s) 

    Knockout mouse of GABAB receptors in the reward system consumed a more high fat diet than wild-type mice when they were given the food intermittently. There were no significant differences in body weight or glucose tolerance between genotypes, suggesting that GABAB receptors in the reward system is not involved in the regulation of energy homeostasis, Baclofen, a GABAB agonist, decreased the consumption of the high fat diet when given just before the high fat diet was presented in wild-type, but not in the knockout mice in the intermittent high fat die protocol. These data indicate that the GABAB neurons in the reward system plays an inhibitory role in the binge eating of a high fat diet.

  10. The role of protein tyrosine phosphatase-1B in the hypothalamic inflammation induced by a high fat diet

    Grant number:15K09381  2015.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Banno Ryoichi

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    Authorship:Principal investigator 

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    Hypothalamus plays an important role in the regulation of energy balance. A high fat diet induces hypothalamic inflammation, which is known to play a causal role in obesity. We investigated the role of protein tyrosine phosphatase-1B(PTP1B), a regulator of leptin, insulin and inflammatory signaling, in the hypothalamic inflammation induced by a high fat diet. Our results suggest that PTP1B in the microglia enhances hypothalamic inflammation, and PTP1B in the astrocye increases body weight under a high fat diet conditions.

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Teaching Experience (On-campus) 14

  1. 修士課程「社会医学」講義

    2021

  2. ベーシックトレーニング

    2021

  3. 基礎医学セミナー

    2021

  4. 基礎医学セミナー

    2020

     詳細を見る

    https://www.med.nagoya-u.ac.jp/medical_J/school/basic-medicine-seminar/

  5. ベーシックトレーニング

    2020

     詳細を見る

    https://www.med.nagoya-u.ac.jp/medical_J/graduate/class/basic-training/

  6. 修士課程「社会医学」講義

    2020

     詳細を見る

    世界中で増加している肥満についてその成り立ちと対策について講義

  7. 健康・スポーツ科学講義

    2019

  8. 修士課程「社会医学」講義

    2019

     詳細を見る

    世界中で増加している肥満についてその成り立ちと対策について講義

  9. 基礎医学セミナー

    2019

     詳細を見る

    https://www.med.nagoya-u.ac.jp/medical_J/school/basic-medicine-seminar/

  10. ベーシックトレーニング

    2019

     詳細を見る

    https://www.med.nagoya-u.ac.jp/medical_J/graduate/class/basic-training/

  11. 健康・スポーツ科学講義

    2018

  12. 修士課程「社会医学」講義

    2018

     詳細を見る

    世界中で増加している肥満についてその成り立ちと対策について講義

  13. 基礎医学セミナー

    2018

     詳細を見る

    https://www.med.nagoya-u.ac.jp/medical_J/school/basic-medicine-seminar/

  14. ベーシックトレーニング

    2018

     詳細を見る

    https://www.med.nagoya-u.ac.jp/medical_J/graduate/class/basic-training/

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Academic Activities 4

  1. 一般演題 摂食調節

    Role(s):Panel moderator, session chair, etc.

    第40回日本肥満学会  2019.11

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    Type:Academic society, research group, etc. 

  2. 一般演題 内分泌・代謝

    Role(s):Panel moderator, session chair, etc.

    第239回日本内科学会東海地方会  2019.10

  3. 一般演題 下垂体

    Role(s):Panel moderator, session chair, etc.

    第92回日本内分泌学会学術総会  2019.5

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    Type:Academic society, research group, etc. 

  4. 一般演題(他の治療)

    Role(s):Panel moderator, session chair, etc.

    第92回日本糖尿病学会中部地方会  2018.9

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    Type:Academic society, research group, etc.