研究者詳細 - 大橋　浩二

論文 - 大橋　浩二

分割表示 97 件中 41 - 60 件目／全件表示 >>

Cardiac Myocyte-Derived Follistatin-Like 1 Prevents Renal Injury in a Subtotal Nephrectomy Model. 査読有り

Hayakawa S, Ohashi K, Shibata R, Kataoka Y, Miyabe M, Enomoto T, Joki Y, Shimizu Y, Kambara T, Uemura Y, Yuasa D, Ogawa H, Matsuo K, Hiramatsu-Ito M, van den Hoff MJ, Walsh K, Murohara T, Ouchi N.

Journal of American Society of Nephrology 頁： in press 2014年7月

Role of anti-inflammatory adipokines in obesity-related diseases. 査読有り

Ohashi K, Shibata R, Murohara T, Ouchi N.

Trend Endocrinology and Metabolism 2014年7月

Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury. 査読有り

Miyabe M, Ohashi K, Shibata R, Uemura Y, Ogura Y, Yuasa D, Kambara T, Kataoka Y, Yamamoto T, Matsuo K, Joki Y, Enomoto T, Hayakawa S, Hiramatsu-Ito M, Ito M, Van Den Hoff MJ, Walsh K, Murohara T, Ouchi N.

Cardiovascular Research 2014年7月

Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms. 査読有り

Kataoka Y, Shibata R, Ohashi K, Kambara T, Enomoto T, Uemura Y, Ogura Y, Yuasa D, Matsuo K, Nagata T, Oba T, Yasukawa H, Numaguchi Y, Sone T, Murohara T, Ouchi N.

Journal of American College of Cardiology 2014年6月

Association of circulating C1q/TNF-related protein 1 levels with coronary artery disease in men. 査読有り

Yuasa D, Ohashi K, Shibata R, Takeshita K, Kikuchi R, Takahashi R, Kataoka Y, Miyabe M, Joki Y, Kambara T, Uemura Y, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Ito M, Ikeda N, Murohara T, Ouchi N.

PLoS One 2014年6月

Association of Circulating C1q/TNF-Related Protein 1 Levels with Coronary Artery Disease in Men 査読有り

Yuasa Daisuke, Ohashi Koji, Shibata Rei, Takeshita Kyosuke, Kikuchi Ryosuke, Takahashi Ryotaro, Kataoka Yoshiyuki, Miyabe Megumi, Joki Yusuke, Kambara Takahiro, Uemura Yusuke, Matsuo Kazuhiro, Hayakawa Satoko, Hiramatsu-Ito Mizuho, Ito Masanori, Ikeda Nobuo, Murohara Toyoaki, Ouchi Noriyuki

PLOS ONE 9 巻 ( 6 ) 頁： e99846 2014年6月

Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes. 査読有り

Ohashi K, Enomoto T, Joki Y, Shibata R, Ogura Y, Kataoka Y, Shimizu Y, Kambara T, Uemura Y, Yuasa D, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Murohara T, Ouchi N.

The Journal of Biological Chemistry 2014年5月

Adiponectin Ameliorates Endotoxin-Induced Acute Cardiac Injury 査読有り

Watanabe Yoshio, Shibata Rei, Ouchi Noriyuki, Kambara Takahiro, Ohashi Koji, Jie Li, Inoue Yoko, Murohara Toyoaki, Komori Kimihiro

BIOMED RESEARCH INTERNATIONAL 2014 巻頁： 382035 2014年

Transcriptional Regulation of an Insulin-Sensitizing Adipokine Adipolin/CTRP12 in Adipocytes by Kruppel-Like Factor 15 査読有り

Enomoto Takashi, Ohashi Koji, Shibata Rei, Kambara Takahiro, Uemura Yusuke, Yuasa Daisuke, Kataoka Yoshiyuki, Miyabe Megumi, Matsuo Kazuhiro, Joki Yusuke, Hayakawa Satoko, Hiramatsu-Ito Mizuho, Ito Masanori, Murohara Toyoaki, Ouchi Noriyuki

PLOS ONE 8 巻 ( 12 ) 頁： e83183 2013年12月

Adiponectin-Mediated Modulation of Lymphatic Vessel Formation and Lymphedema 査読有り

Shimizu Yuuki, Shibata Rei, Ishii Masakazu, Ohashi Koji, Kambara Takahiro, Uemura Yusuke, Yuasa Daisuke, Kataoka Yoshiyuki, Kihara Shinji, Murohara Toyoaki, Ouchi Noriyuki

JOURNAL OF THE AMERICAN HEART ASSOCIATION 2 巻 ( 5 ) 頁： e000438 2013年10月

Role of Adipocytokines in Regulation of Revascularization Responses

Ouchi Noriyuki, Ohashi Koji, Shibata Rei, Murohara Toyoaki

JOURNAL OF CARDIAC FAILURE 19 巻 ( 10 ) 頁： S120 - S120 2013年10月

Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation 査読有り

Yusuke Uemura, Rei Shibata, Koji Ohashi, Takashi Enomoto, Takahiro Kambara, Takashi Yamamoto, Yasuhiro Ogura, Daisuke Yuasa, Yusuke Joki, Kazuhiro Matsuo, Megumi Miyabe, Yoshiyuki Kataoka, Toyoaki Murohara, Noriyuki Ouchi

FASEB Journal 27 巻 ( 1 ) 頁： 25 - 33 2013年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Obesity is closely associated with the progression of vascular disorders, including atherosclerosis and postangioplasty restenosis. C1q/TNF-related protein (CTRP) 9 is an adipocytokine that is down-regulated in obese mice. Here we investigated whether CTRP9 modulates neointimal hyperplasia and vascular smooth muscle cell (VSMC) proliferation in vivo and in vitro. Left femoral arteries of wild-type (WT) mice were injured by a steel wire. An adenoviral vector expressing CTRP9 (Ad-CTRP9) or β-galactosidase as a control was intravenously injected into WT mice 3 d before vascular injury. Delivery of Ad-CTRP9 significantly attenuated the neointimal thickening and the number of bromodeoxyuridine-positive proliferating cells in the injured arteries compared with that of control. Treatment of VSMCs with CTRP9 protein attenuated the proliferative and chemotactic activities induced by growth factors including platelet-derived growth factor (PDGF)-BB, and suppressed PDGF-BB-stimulated phosphorylation of ERK. CTRP9 treatment dose-dependently increased cAMP levels in VSMCs. Blockade of cAMP-PKA pathway reversed the inhibitory effect of CTRP9 on DNA synthesis and ERK phosphorylation in response to PDGF-BB. The present data indicate that CTRP9 functions to attenuate neointimal formation following vascular injury through its ability to inhibit VSMC growth via cAMP-dependent mechanism, suggesting that the therapeutic approaches to enhance CTRP9 production could be valuable for prevention of vascular restenosis after angioplasty. © FASEB.

DOI： 10.1096/fj.12-213744

Scopus

PubMed

Regulation of adipolin/CTRP12 cleavage by obesity 査読有り

Enomoto Takashi, Shibata Rei, Ohashi Koji, Kambara Takahiro, Kataoka Yoshiyuki, Uemura Yusuke, Yuasa Daisuke, Murohara Toyoaki, Ouchi Noriyuki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 428 巻 ( 1 ) 頁： 155 - 159 2012年11月

Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models. 査読有り

Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T.

Circulation 2012年10月

Omentin as a novel biomarker of metabolic risk factors 査読有り

Shibata Rei, Ouchi Noriyuki, Takahashi Ryotaro, Terakura Yuya, Ohashi Koji, Ikeda Nobuo, Higuchi Akiko, Terasaki Hiroko, Kihara Shinji, Murohara Toyoaki

DIABETOLOGY & METABOLIC SYNDROME 4 巻 ( 1 ) 頁： 37 2012年7月

Anti-inflammatory and anti-atherogenic properties of adiponectin. 査読有り

Ohashi K, Ouchi N, Matsuzawa Y.

Biochimie 2012年6月

CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism. 査読有り

Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N.

The Journal of Biological Chemistry 2012年6月

Fat-derived Factor Omentin Stimulates Endothelial Cell Function and Ischemia-induced Revascularization via Endothelial Nitric Oxide Synthase-dependent Mechanism 査読有り

Maruyama Sonomi, Shibata Rei, Kikuchi Ryosuke, Izumiya Yasuhiro, Rokutanda Taku, Araki Satoshi, Kataoka Yoshiyuki, Ohashi Koji, Daida Hiroyuki, Kihara Shinji, Ogawa Hisao, Murohara Toyoaki, Ouchi Noriyuki

JOURNAL OF BIOLOGICAL CHEMISTRY 287 巻 ( 1 ) 頁： 408 - 417 2012年1月

Adipocytokines and obesity-linked disorders 査読有り

Noriyuki Ouchi, Koji Ohashi, Rei Shibata, Toyoaki Murohara

Nagoya Journal of Medical Science 74 巻 ( 1-2 ) 頁： 19 - 30 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）

Obesity is closely associated with an increased risk for metabolic and cardiovascular diseases. Adipose tissue produces a number of secretory bioactive substances, also known as adipocytokines or adipokines, which directly affect adjacent or distant organs. Most adipocytokines are pro-inflammatory, thereby promoting the obesity-linked disorders. In contrast, there are a small number of adipocytokines that exhibit antiinflammatory properties. It is now recognized that dysregulated production or secretion of adipocytokines caused by adipocyte dysfunction leads to the development of obesity-linked complications. In this review, we focus on the functional role of several adipocytokines in metabolic and cardiovascular diseases.

Scopus

PubMed

Circulating omentin is associated with coronary artery disease in men 査読有り

Shibata Rei, Ouchi Noriyuki, Kikuchi Ryosuke, Takahashi Ryotaro, Takeshita Kyosuke, Kataoka Yoshiyuki, Ohashi Koji, Ikeda Nobuo, Kihara Shinji, Murohara Toyoaki

ATHEROSCLEROSIS 219 巻 ( 2 ) 頁： 811 - 814 2011年12月

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