Elaborate cooperation of poly(rC)-binding proteins 1/2 and glutathione in ferroptosis induced by plasma-activated Ringer's lactate. Reviewed

Jiang L, Zheng H, Ishida M, Lyu Q, Akatsuka S, Motooka Y, Sato K, Sekido Y, Nakamura K, Tanaka H, Ishikawa K, Kajiyama H, Mizuno M, Hori M, Toyokuni S.

  Vol. 214   page： 28 - 41   2024.3

BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile-induced mesothelioma via ferroptosis resistance. Reviewed

Luo Y, Akatsuka S, Motooka Y, Kong Y, Zheng H, Mashimo T, Imaoka T, Toyokuni S.

Cancer science   Vol. 114 ( 4 ) page： 1423 - 1436   2023.4

Environmental impact on carcinogenesis under BRCA1 haploinsufficiency. Invited Reviewed Open Access

Toyokuni S, Kong Y, Motooka Y, Akatsuka S.

Genes Environ   Vol. 45 ( 1 ) page： 2   2023.1

Iron as spirit of life to share under monopoly. Invited Reviewed Open Access

Toyokuni S, Kong Y, Zheng H, Maeda Y, Motooka Y, Akatsuka S.

J Clin Biochem Nutr   Vol. 71 ( 2 ) page： 78 - 88   2022.9

BRCA1 haploinsufficiency promotes chromosomal amplification under Fenton reaction-based carcinogenesis through ferroptosis-resistance. Reviewed Open Access

Kong Y, Akatsuka S, Motooka Y, Zheng H, Cheng Z, Shiraki Y, Mashimo T, Imaoka T, Toyokuni S.

Redox biology   Vol. 54 ( 102356 ) page： 1 - 13   2022.8

Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma.

Yamashita K, Kohashi K, Yamada Y, Akatsuka S, Ikuta K, Nishida Y, Toyokuni S, Oda Y

Genes, chromosomes & cancer   Vol. 60 ( 1 ) page： 26 - 37   2021.1

Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue.

Homma T, Takeda Y, Nakano T, Akatsuka S, Kinoshita D, Kurahashi T, Saitoh S, Yamada KI, Miyata S, Asao H, Goto K, Watanabe T, Watanabe M, Toyokuni S, Fujii J

Free radical biology & medicine   Vol. 162   page： 255 - 265   2021.1

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering. Open Access

Toyokuni S, Kong Y, Cheng Z, Sato K, Hayashi S, Ito F, Jiang L, Yanatori I, Okazaki Y, Akatsuka S

Cancers   Vol. 12 ( 11 )   2020.11

Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice.

Hayashi S, Nakamura T, Motooka Y, Ito F, Jiang L, Akatsuka S, Iwase A, Kajiyama H, Kikkawa F, Toyokuni S

Redox biology   Vol. 37   page： 101726   2020.10

Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium. Open Access

Ito F, Yanatori I, Maeda Y, Nimura K, Ito S, Hirayama T, Nagasawa H, Kohyama N, Okazaki Y, Akatsuka S, Toyokuni S

Redox biology   Vol. 36   page： 101616   2020.9

Overexpression of miR-199/214 is a distinctive feature of iron-induced and asbestos-induced sarcomatoid mesothelioma in rats. Open Access

Okazaki Y, Chew SH, Nagai H, Yamashita Y, Ohara H, Jiang L, Akatsuka S, Takahashi T, Toyokuni S

Cancer science   Vol. 111 ( 6 ) page： 2016 - 2027   2020.6

Frequent homozygous deletion of Cdkn2a/2b in tremolite-induced malignant mesothelioma in rats. Open Access

Okazaki Y, Misawa N, Akatsuka S, Kohyama N, Sekido Y, Takahashi T, Toyokuni S

Cancer science   Vol. 111 ( 4 ) page： 1180 - 1192   2020.4

<i>Mth1</i> deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice.

Funahashi S, Okazaki Y, Akatsuka S, Takahashi T, Sakumi K, Nakabeppu Y, Toyokuni S

Free radical research   Vol. 54 ( 2-3 ) page： 195 - 205   2020.3

Superiority of rat over murine model for studies on the evolution of cancer genome Open Access

Akatsuka S, Li GH, Toyokuni S.

Free Radic Res.   Vol. 52 ( 11-12 ) page： 1323 - 1327   2018.12

Expression of P-REX2a is associated with poor prognosis in endometrial malignancies. Reviewed

Takeshita S, Yamashita Y, Shiomi K, Suzuki N, Yoshida J, Naiki-Ito A, Suzuki S, Akatsuka S, Toyokuni S, Takahashi T, Mase S, Arakawa A, Sugiura-Ogasawara M, Takahashi S

Oncotarget   Vol. 9 ( 37 ) page： 24778-24786   2018.5

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model. Open Access

Li GH, Akatsuka S, Chew SH, Jiang L, Nishiyama T, Sakamoto A, Takahashi T, Futakuchi M, Suzuki H, Sakumi K, Nakabeppu Y, Toyokuni S.

Pathol Int.   Vol. 67 ( 11 ) page： 564 - 574   2017.11

Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis. Open Access

Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S.

Free Radic Biol Med.   Vol. 108   page： 610 - 626   2017.7

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma.

Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S

Free radical biology & medicine   Vol. 106   page： 91 - 99   2017.5

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma. Reviewed

Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S.

Free Radic Biol Med   Vol. 106   page： 91-99   2017.2

Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma. Reviewed

Wang S, Jiang L, Han Y, Chew SH, Ohara Y, Akatsuka S, Weng L, Kawaguchi K, Fukui T, Sekido Y, Yokoi K, Toyokuni S.

Oncotarget   Vol. 7 ( 43 ) page： 69565-69578   2016.10

Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis. Reviewed

Jiang L, Chew SH, Nakamura K, Ohara Y, Akatsuka S, Toyokuni S.

Cancer Sci   Vol. 107 ( 7 ) page： 908-915   2016.7

Pain-reducing anesthesia prevents oxidative stress in human term placenta. Reviewed

Tsuzuki Y, Yamashita Y, Hattori Y, Li GH, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S.

J Clin Biochem Nutr   Vol. 58 ( 2 ) page： 156-160   2016.3

Genome-wide Profiling of 8-Oxoguanine Reveals Its Association with Spatial Positioning in Nucleus. Reviewed

Yoshihara M, Jiang L, Akatsuka S, Suyama M, Toyokuni S.

DNA Res.   Vol. 21 ( 6 ) page： 603-612   2014.12

Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. Reviewed

Jiang L, Yamashita Y, Chew SH, Akatsuka S, Ukai S, Wang S, Nagai H, Okazaki Y, Takahashi T, Toyokuni S.

J Pathol.   Vol. 233 ( 4 ) page： 402-414   2014.8

Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Reviewed

Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, Shibata K, Kajiyama H, Kikkawa F, Toyokuni S.

Int J Cancer.   Vol. 135 ( 2 ) page： 308-218   2014.7

Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production. Reviewed

Chew SH, Okazaki Y, Nagai H, Misawa N, Akatsuka S, Yamashita K, Jiang L, Yamashita Y, Noguchi M, Hosoda K, Sekido Y, Takahashi T, Toyokuni S.

Carcinogenesis   Vol. 35 ( 1 ) page： 164-172   2014.1

Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. Reviewed Open Access

Yamashita Y, Akatsuka S, Shinjo K, Yatabe Y, Kobayashi H, Seko H, Kajiyama H, Kikkawa F, Takahashi T, Toyokuni S.

PLoS One   Vol. 8 ( 3 ) page： e57724   2013.3

Metamorphosis of mesothelial cells with active horizontal motility in tissue culture. Reviewed

Nagai H, Chew SH, Okazaki Y, Funahashi S, Namba T, Kato T, Enomoto A, Jiang L, Akatsuka S, Toyokuni S.

Sci Rep   Vol. 3   page： 1144   2013.1

Iron overload signature in chrysotile-induced malignant mesothelioma. Reviewed

Jiang L, Akatsuka S, Nagai H, Chew SH, Ohara H, Okazaki Y, Yamashita Y, Yoshikawa Y, Yasui H, Ikuta K, Sasaki K, Kohgo Y, Hirano S, Shinohara Y, Kohyama N, Takahashi T, Toyokuni S.

J Pathol   Vol. 228 ( 3 ) page： 366-377   2012.11

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer. Reviewed Open Access

Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S.

PLoS One   Vol. 7 ( 8 ) page： e43403   2012.8

The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis. Reviewed

Kobayashi H, Yamashita Y, Iwase A, Yoshikawa Y, Yasui H, Kawai Y, Uchida K, Uno N, Akatsuka S, Takahashi T, Kikkawa F, Toyokuni S.

Fertil Steril   Vol. 98 ( 2 ) page： 415-422   2012.8

Genome-wide assessment of oxidatively generated DNA damage. Invited Reviewed

Akatsuka S, Toyokuni S.

Free Radic Res   Vol. 46 ( 4 ) page： 523-530   2012.4

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Reviewed

Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, Ishihara T, Yamashita K, Yoshikawa Y, Yasui H, Jiang L, Ohara H, Takahashi T, Ichihara G, Kostarelos K, Miyata Y, Shinohara H, Toyokuni S.

Proc Natl Acad Sci U S A.   Vol. 108 ( 49 ) page： E1330-E1338   2011.12

Free calvarial periosteum graft vascularized by an omental flap in a rat model. Reviewed

Nakazato K, Toriyama K, Hishida M, Takanari K, Yagi S, Yamashita Y, Akatsuka S, Hayakawa A, Kamei Y.

Ann Plast Surg   Vol. 67 ( 6 ) page： 649-654   2011.12

Age- and sun exposure-dependent differences in 8-hydroxy-2'-deoxyguanosine and N-(carboxymethyl)lysine in human epidermis. Reviewed

Toyokuni S, Hirao A, Wada T, Nagai R, Date A, Yoshii T, Akatsuka S, Yamashita Y, Kawada A.

J Clin Biochem Nutr   Vol. 49 ( 2 ) page： 121-124   2011.9

XCR1 expression and biased VH gene usage are distinct features of diffuse large B-cell lymphoma initially manifesting in the bone marrow. Reviewed

Yamashita Y, Kajiura D, Tang L, Hasegawa Y, Kinoshita T, Nakamura S, Akatsuka S, Toyokuni S, Mori N.

Am J Clin Pathol   Vol. 135 ( 4 ) page： 556-564   2011.4

LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma Reviewed

Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y.

Cancer Res.   Vol. 71 ( 3 ) page： 873-883   2011.2

Stage-specific roles of fibulin-5 during oxidative stress-induced renal carcinogenesis in rats Reviewed

Ohara H, Akatsuka S, Nagai H, Liu YT, Jiang L, Okazaki Y, Yamashita Y, Nakamura T, Toyokuni S.

Free Radic Res   Vol. 45 ( 2 ) page： 211-220   2011.2

Genome-scale approaches to investigate oxidative DNA damage Reviewed

Akatsuka S, Toyokuni S.

J Clin Biochem Nutr   Vol. 47 ( 2 ) page： 91-97   2010.9

Suppression of SLC11A2 expression is essential to maintain duodenal integrity during dietary iron overload Reviewed

Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, Kishi F, Jiang L, Akatsuka S, Nakao K, Toyokuni S.

Am J Pathol   Vol. 177 ( 2 ) page： 677-685   2010.8

*A quantitative trait locus responsible for inducing B‐cell lymphoblastic lymphoma is a hotspot for microsatellite instability Reviewed

Kaszynski RH, Akatsuka S, Hiratsuka T, Jin G, Ozeki M, Okuno T, Nakamura T, Manabe T, Takakuwa T, Hiai H, Toyokuni S, Tamaki K, Tsuruyama T.

Cancer Sci   Vol. 101 ( 3 ) page： 800-805   2010.3

Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. Reviewed

Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, Takahashi T, Toyokuni S.

Lab Invest   Vol. 90 ( 3 ) page： 360-373   2010.3

Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma. Reviewed

Zhong Y, Onuki J, Yamasaki T, Ogawa O, Akatsuka S, Toyokuni S.

Carcinogenesis   Vol. 30 ( 1 ) page： 158-164   2009.1

Characteristics and modifying factors of asbestos-induced oxidative DNA damage Reviewed

Jiang L, Nagai H, Ohara H, Hara S, Tachibana M, Hirano S, Shinohara Y, Kohyama N, Akatsuka S, Toyokuni S

Cancer Sci   Vol. 99 ( 11 ) page： 2142-2151   2008.11

*Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway Reviewed

Liu YT, Shang D, Akatsuka S, Ohara H, Dutta KK, Mizushima K, Naito Y, Yoshikawa T, Izumiya M, Abe K, Nakagama H, Noguchi N, Toyokuni S

Am J Pathol   Vol. 171 ( 6 ) page： 1978-1988   2007.12

Association of microRNA-34a overexpression with proliferation is cell type-dependent Reviewed

Dutta KK, Zhong Y, Liu YT, Yamada T, Akatsuka S, Hu Q, Yoshihara M, Ohara H, Takehashi M, Shinohara T, Masutani H, Onuki J, Toyokuni S

Cancer Sci   Vol. 98 ( 12 ) page： 1845-1852   2007.12

Pathological investigation of oxidative stress in the post-genomic era Reviewed

Toyokuni S, Akatsuka S.

Pathol Int   Vol. 57 ( 8 ) page： 461-473   2007.12

Novel screening method for ultraviolet protection: combination of a human skin-equivalent model and 8-hydroxy-2'-deoxyguanosine Reviewed

Toyokuni S, Yasui H, Date A, Hakozaki T, Akatsuka S, Kohda H, Yoshii T, Sakurai H

Pathol Int   Vol. 56 ( 12 ) page： 760-762   2006.12

Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment Reviewed

Jiang L, Zhong Y, Akatsuka S, Liu Y-T, Dutta KK, Lee W-H, Onuki J, Masymura K, Nohmi T, Toyokuni S

Cancer Sci   Vol. 97 ( 11 ) page： 1159-1167   2006.11

*Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis. Reviewed

Akatsuka S, Aung TT, Dutta KK, Jiang L, Lee W-H, Liu Y-T, Onuki J, Shirase T, Yamasaki K, Ochi H, Naito Y, Yoshikawa T, Kasai H, Tominaga Y, Sakumi K, Nakabeppu Y, Kawai Y, Uchida K, Yamasaki A, Tsuruyama T, Yamada Y, Toyokuni S

Am J Pathol   Vol. 169 ( 4 ) page： 1328-1342   2006.10

Alpha-tocopherol induces calnexin in renal tubular cells: another protective mechanism against free radical-induced cellular damage Reviewed

Lee W-H, Akatsuka S, Shirase T, Dutta KK, Jiang L, Liu Y-T, Onuki J, Yamada Y, Okawa K, Wada Y, Watanabe A, Kohro T, Noguchi N, Toyokuni S

Arch Biochem Biophys   Vol. 453 ( 2 ) page： 168-178   2006.9

What has been learned from the studies of oxidative stress-induced carcinogenesis: proposal of the concept of oxygenomics Reviewed

Toyokuni S, Akatsuka S.

J Clin Biochem Nutr   Vol. 39 ( 1 ) page： 3-10   2006.7

Susceptibility of actin to modification by 4-hydroxy-2-nonenal Reviewed

Ozeki M, Miyagawa-Hayashino A, Akatsuka S, Shirase T, Lee W-H, Uchida K, Toyokuni S

J Chromatogr B Analyt Technol Biomed Life Sci   Vol. 827 ( 1 ) page： 119-126   2005.11

Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis Reviewed

Dutta KK, Nishinaka Y, Masutani H, Akatsuka S, Aung TT, Shirase T, Lee W-H, Yamada Y, Hiai H, Yodoi J, Toyokuni S

Lab Invest   Vol. 85 ( 6 ) page： 798-807   2005.6

Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis Reviewed

Tanaka T, Akatsuka S, Ozeki M, Shirase T, Hiai H, Toyokuni S

Oncogene   Vol. 23 ( 22 ) page： 3980-3989   2004.5

Detection of glyceraldehyde 3-phosphate dehydrogenase messenger RNA using a peptide nucleic acid probe in paraffin-embedded archival specimens Reviewed

Hiroyasu M, Akatsuka S, Shirase T, Toda Y, Hiai H, Toyokuni S

Pathol Int   Vol. 54 ( 4 ) page： 251-255   2004.4

Effects of phenolic contents of Mauritian endemic plant extracts on promoter activities of antioxidant enzymes Reviewed

Toyokuni S, Tanaka T, Kawaguchi W, Fang NRL, Ozeki M, Akatsuka S, Hiai H, Aruoma OI, Bahorun T

Free Radic Res   Vol. 37 ( 11 ) page： 1215-1224   2003.11

Intermittent microwave irradiation facilitates antigen-antibody reaction in Western blot analysis Reviewed

Toyokuni S, Kawaguchi W, Akatsuka S, Hiroysu M, Hiai H

Pathol Int   Vol. 53 ( 4 ) page： 259-261   2003.4

Temperature dependencies of spreading coefficients of hydrocarbons on water Reviewed

Akatsuka S, Yoshigiwa H, Mori YH

J Colloid Interf Sci   Vol. 172 ( 2 ) page： 335-340   1995.6

酸化ストレスによるゲノム変化と発がん

赤塚慎也，豊國伸哉（ Role： Joint author）

羊土社（実験医学 30巻 17号 2779-2785頁）  2012.11 

鉄・酸化ストレスによる発癌の分子機構を探る

赤塚慎也，豊國伸哉（ Role： Joint author）

先端医学社（分子消化器病 5巻 1号 39-48頁）  2008.3 

生体金属と活性酸素・フリーラジカル

赤塚慎也，豊國伸哉（ Role： Joint author）

アグネ技術センター（金属 77巻 3号 305-310頁）  2007.3 

オキシゲノミクス－酸化ストレス発癌とゲノム

赤塚慎也，豊國伸哉（ Role： Joint author）

医歯薬出版株式会社（別冊・医学のあゆみ「酸化ストレス Ver.2」 16-19頁）  2006.10