Gut microbiota in dementia with Lewy bodies

Nishiwaki Hiroshi, Ueyama Jun, Kashihara Kenichi, Ito Mikako, Hamaguchi Tomonari, Maeda Tetsuya, Tsuboi Yoshio, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji

NPJ PARKINSONS DISEASE   8 巻 ( 1 ) 頁： 169   2022年12月

Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative Colitis

Gibo Noriaki, Hamaguchi Tomonari, Miki Yasuo, Yamamura Takeshi, Nakaguro Masato, Ito Mikako, Nakamura Masanao, Kawashima Hiroki, Hirayama Masaaki, Hirooka Yoshiki, Wakabayashi Koichi, Ohno Kinji

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES   31 巻 ( 3 ) 頁： 290 - 300   2022年9月

Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson's disease

Nishiwaki Hiroshi, Ito Mikako, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Yoshida Takumi, Hanada Hiroyuki, Takeuchi Ichiro, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji

NPJ PARKINSONS DISEASE   8 巻 ( 1 ) 頁： 65   2022年6月

Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria

Toda Takuro, Ito Mikako, Takeda Jun-ichi, Masuda Akio, Mino Hiroyuki, Hattori Nobutaka, Mohri Kaneo, Ohno Kinji

COMMUNICATIONS BIOLOGY   5 巻 ( 1 ) 頁： 453   2022年5月

Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria 査読有り

Takuro Toda; Mikako Ito; Jun-ichi Takeda; Akio Masuda; Hiroyuki Mino; Nobutaka Hattori; Kaneo Mohri; Kinji Ohno

Communications Biology   5 巻   頁： 453   2022年5月

Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response

Hasegawa Tomoya, Ito Mikako, Hasegawa Satoru, Teranishi Masaki, Takeda Koki, Negishi Shuto, Nishiwaki Hiroshi, Takeda Jun-ichi, LeBaron Tyler W., Ohno Kinji

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   23 巻 ( 5 )   2022年3月

Meclozine ameliorates skeletal muscle pathology and increases muscle forces in mdx mice

Kawamura Yusuke, Hida Tetsuro, Ohkawara Bisei, Matsushita Masaki, Kobayashi Takeshi, Ishizuka Shinya, Hiraiwa Hideki, Tanaka Satoshi, Tsushima Mikito, Nakashima Hiroaki, Ito Kenyu, Imagama Shiro, Ito Mikako, Masuda Akio, Ishiguro Naoki, Ohno Kinji

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   592 巻   頁： 87 - 92   2022年2月

Altered gut microbiota in Parkinson's disease patients with motor complications

Takahashi Kai, Nishiwaki Hiroshi, Ito Mikako, Iwaoka Kazuhiro, Takahashi Kenta, Suzuki Yoshio, Taguchi Keita, Yamahara Kanako, Tsuboi Yoshio, Kashihara Kenichi, Hirayama Masaaki, Ohno Kinji, Maeda Tetsuya

PARKINSONISM & RELATED DISORDERS   95 巻   頁： 11 - 17   2022年2月

Enhancement of ethanol production and cell growth in budding yeast by direct irradiation of low-temperature plasma

Tanaka Hiromasa, Matsumura Shogo, Ishikawa Kenji, Hashizume Hiroshi, Ito Masafumi, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Ito Mikako, Ohno Kinji, Okazaki Yasumasa, Toyokuni Shinya, Mizuno Masaaki, Hori Masaru

JAPANESE JOURNAL OF APPLIED PHYSICS   61 巻 ( SA )   2022年1月

Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate

Hirayama Masaaki, Nishiwaki Hiroshi, Hamaguchi Tomonari, Ito Mikako, Ueyama Jun, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ohno Kinji

PLOS ONE   16 巻 ( 11 ) 頁： e0260451   2021年11月

Regulated splicing of large exons is linked to phase-separation of vertebrate transcription factors

Kawachi Toshihiko, Masuda Akio, Yamashita Yoshihiro, Takeda Jun-ichi, Ohkawara Bisei, Ito Mikako, Ohno Kinji

EMBO JOURNAL   40 巻 ( 22 ) 頁： e107485   2021年11月

Plasma-activated Ringer's lactate solution inhibits the cellular respiratory system in HeLa cells

Tanaka Hiromasa, Maeda Shogo, Nakamura Kae, Hashizume Hiroshi, Ishikawa Kenji, Ito Mikako, Ohno Kinji, Mizuno Masaaki, Motooka Yashiro, Okazaki Yasumasa, Toyokuni Shinya, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru

PLASMA PROCESSES AND POLYMERS   18 巻 ( 10 )   2021年10月

Zonisamide upregulates neuregulin-1 expression and enhances acetylcholine receptor clustering at the in vitro neuromuscular junction

Inoue Taro, Ohkawara Bisei, Bushra Samira, Kanbara Shunsuke, Nakashima Hiroaki, Koshimizu Hiroyuki, Tomita Hiroyuki, Ito Mikako, Masuda Akio, Ishiguro Naoki, Imagama Shiro, Ohno Kinji

NEUROPHARMACOLOGY   195 巻   頁： 108637   2021年9月

Secreted Signaling Molecules at the Neuromuscular Junction in Physiology and Pathology

Ohkawara Bisei, Ito Mikako, Ohno Kinji

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   22 巻 ( 5 )   2021年3月

Zonisamide ameliorates neuropathic pain partly by suppressing microglial activation in the spinal cord in a mouse model

Koshimizu Hiroyuki, Ohkawara Bisei, Nakashima Hiroaki, Ota Kyotaro, Kanbara Shunsuke, Inoue Taro, Tomita Hiroyuki, Sayo Akira, Kiryu-Seo Sumiko, Konishi Hiroyuki, Ito Mikako, Masuda Akio, Ishiguro Naoki, Imagama Shiro, Kiyama Hiroshi, Ohno Kinji

LIFE SCIENCES   263 巻   頁： 118577   2020年12月

A set of random forest models for each amino acid substitution to predict pathogenicity of missense variants in the human genome

Takeda J., Nanatsue K., Yamagishi R., Ito M., Ohno K.

EUROPEAN JOURNAL OF HUMAN GENETICS   28 巻 ( SUPPL 1 ) 頁： 1003 - 1003   2020年12月

Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage

Takeuchi Akihide, Takahashi Yuji, Iida Kei, Hosokawa Motoyasu, Irie Koichiro, Ito Mikako, Brown J. B., Ohno Kinji, Nakashima Kinichi, Hagiwara Masatoshi

STEM CELL REPORTS   15 巻 ( 4 ) 頁： 883 - 897   2020年10月

Gene Expression Profile at the Motor Endplate of the Neuromuscular Junction of Fast-Twitch Muscle

Huang Kun, Li Jin, Ito Mikako, Takeda Jun-Ichi, Ohkawara Bisei, Ogi Tomoo, Masuda Akio, Ohno Kinji

FRONTIERS IN MOLECULAR NEUROSCIENCE   13 巻   頁： 154   2020年9月

Meta-Analysisof Gut Dysbiosis in Parkinson's Disease

Nishiwaki Hiroshi, Ito Mikako, Ishida Tomohiro, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Shimamura Teppei, Mori Hiroshi, Kurokawa Ken, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji

MOVEMENT DISORDERS   35 巻 ( 9 ) 頁： 1626 - 1635   2020年9月

CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction

Ohkawara Bisei, Kobayakawa Akinori, Kanbara Shunsuke, Hattori Takako, Kubota Satoshi, Ito Mikako, Masuda Akio, Takigawa Masaharu, Lyons Karen M., Ishiguro Naoki, Ohno Kinji

EMBO REPORTS   21 巻 ( 8 ) 頁： e48462   2020年8月

Zonisamide ameliorates progression of cervical spondylotic myelopathy in a rat model

Kanbara Shunsuke, Ohkawara Bisei, Nakashima Hiroaki, Ohta Kyotaro, Koshimizu Hiroyuki, Inoue Taro, Tomita Hiroyuki, Ito Mikako, Masuda Akio, Ishiguro Naoki, Imagama Shiro, Ohno Kinji

SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁： 13138   2020年8月

InMeRF: prediction of pathogenicity of missense variants by individual modeling for each amino acid substitution

Takeda Jun-ichi, Nanatsue Kentaro, Yamagishi Ryosuke, Ito Mikako, Haga Nobuhiko, Hirata Hiromi, Ogi Tomoo, Ohno Kinji

NAR GENOMICS AND BIOINFORMATICS   2 巻 ( 2 ) 頁： lqaa038   2020年6月

tRIP-seq reveals repression of premature polyadenylation by co-transcriptional FUS-U1 snRNP assembly

Masuda Akio, Kawachi Toshihiko, Takeda Jun-ichi, Ohkawara Bisei, Ito Mikako, Ohno Kinji

EMBO REPORTS   21 巻 ( 5 ) 頁： e49890   2020年5月

tRIP-seq reveals repression of premature polyadenylation by co-transcriptional FUS-U1 snRNP assembly

Masuda Akio, Kawachi Toshihiko, Takeda Jun-ichi, Ohkawara Bisei, Ito Mikako, Ohno Kinji

EMBO REPORTS   21 巻 ( 5 ) 頁： .   2020年5月

Fluctuating Weak Magnetic Fields Induce Marked Mitophagy

Toda Takuro, Ito Mikako, Mori Kaneo, Ohno Kinji

FASEB JOURNAL   34 巻   2020年4月

Molecular Hydrogen Manages Mitochondrial Proteostatic Stress and Induces Cellular Response

Hasegawa Tomoya, Ito Mikako, Hasegawa Satoru, Takeda Kouki, Nishiwaki Hiroshi, Negishi Shuto, Ohno Kinji

FASEB JOURNAL   34 巻   2020年4月

SRSF3 and hnRNP K Antagonistically Regulate Splicing of Large Exons

Kawachi Toshihiko, Masuda Akio, Takeda Jun-ichi, Ito Mikako, Hamaguchi Tomonari, Ohno Kinji

FASEB JOURNAL   34 巻   2020年4月

Mianserin suppresses R-spondin 2-induced activation of Wnt/beta-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis (vol 12, 4512, 2019)

Okura Toshiaki, Ohkawara Bisei, Takegami Yasuhiko, Ito Mikako, Masuda Akio, Seki Taisuke, Ishiguro Naoki, Ohno Kinji

SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁： 2995   2020年2月

Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells

Huang Kun, Masuda Akio, Chen Guiying, Bushra Samira, Kamon Masayoshi, Araki Toshiyuki, Kinoshita Masanobu, Ohkawara Bisei, Ito Mikako, Ohno Kinji

SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁： 2558   2020年2月

Hydrogen water alleviates obliterative airway disease in mice

Ozeki Naoki, Yamawaki-Ogata Aika, Narita Yuji, Mii Shinji, Ushida Kaori, Ito Mikako, Hirano Shin-ichi, Kurokawa Ryosuke, Ohno Kinji, Usui Akihiko

GENERAL THORACIC AND CARDIOVASCULAR SURGERY   68 巻 ( 2 ) 頁： 158 - 163   2020年2月

Freeze-drying enables homogeneous and stable sample preparation for determination of fecal short-chain fatty acids

Ueyama Jun, Oda Masaya, Hirayama Masaaki, Sugitate Kuniyo, Sakui Norihiro, Hamada Risa, Ito Mikako, Saito Isao, Ohno Kinji

ANALYTICAL BIOCHEMISTRY   589 巻   頁： 113508   2020年1月

Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder 査読有り

Nishiwaki Hiroshi, Hamaguchi Tomonari, Ito Mikako, Ishida Tomohiro, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Shimamura Teppei, Mori Hiroshi, Kurokawa Ken, Katsuno Masahisa, Hirayama Masaaki, Ohnoa Kinji

MSYSTEMS   5 巻 ( 6 ) 頁： e00797-20   2020年

Mianserin suppresses R-spondin 2-induced activation of Wnt/beta-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis

Okura Toshiaki, Ohkawara Bisei, Takegami Yasuhiko, Ito Mikako, Masuda Akio, Seki Taisuke, Ishiguro Naoki, Ohno Kinji

SCIENTIFIC REPORTS   9 巻 ( 1 ) 頁： 2808   2019年2月

Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease

Suzuki Anzu, Ito Mikako, Hamaguchi Tomonori, Mori Hiroshi, Takeda Yuka, Baba Ryuko, Watanabe Takeshi, Kurokawa Ken, Asakawa Susumu, Hirayama Masaaki, Ohno Kinji

PLOS ONE   13 巻 ( 12 ) 頁： e0208313   2018年12月

Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction

Li Jin, Ito Mikako, Ohkawara Bisei, Masuda Akio, Ohno Kinji

SCIENTIFIC REPORTS   8 巻 ( 1 ) 頁： 13577   2018年9月

Randomized, Double-Blind, Multicenter Trial of Hydrogen Water for Parkinson's Disease

Yoritaka Asako, Ohtsuka Chigumi, Maeda Tetsuya, Hirayama Masaaki, Abe Takashi, Watanabe Hirohisa, Saiki Hidemoto, Oyama Genko, Fukae Jiro, Shimo Yasushi, Hatano Taku, Kawajiri Sumihiro, Okuma Yasuyuki, Machida Yutaka, Miwa Hideto, Suzuki Chikako, Kazama Asuka, Tomiyama Masahiko, Kihara Takeshi, Hirasawa Motoyuki, Shimura Hideki, Oda Eisei, Ito Mikako, Ohno Kinji, Hattori Nobutaka

MOVEMENT DISORDERS   33 巻 ( 9 ) 頁： 1505 - 1507   2018年9月

Protein-anchoring therapy to target extracellular matrix proteins to their physiological destinations

Ito Mikako, Ohno Kinji

MATRIX BIOLOGY   68-69 巻   頁： 628 - 636   2018年8月

Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain

Takeuchi Akihide, Iida Kei, Tsubota Toshiaki, Hosokawa Motoyasu, Denawa Masatsugu, Brown J. B., Ninomiya Kensuke, Ito Mikako, Kimura Hiroshi, Abe Takaya, Kiyonari Hiroshi, Ohno Kinji, Hagiwara Masatoshi

CELL REPORTS   23 巻 ( 5 ) 頁： 1326-1341   2018年5月

Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles

Nishiwaki Hiroshi, Ito Mikako, Negishi Shuto, Sobue Sayaka, Ichihara Masatoshi, Ohno Kinji

FREE RADICAL RESEARCH   52 巻 ( 4 ) 頁： 434 - 445   2018年

Inhalation of hydrogen gas elevates urinary 8-hydroxy-2 '-deoxyguanine in Parkinson's disease

Hirayama Masaaki, Ito Mikako, Minato Tomomi, Yoritaka Asako, LeBaron Tyler W., Ohno Kinji

MEDICAL GAS RESEARCH   8 巻 ( 4 ) 頁： 144 - +   2018年

Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/beta-catenin signaling

Miyamoto Kentaro, Ohkawara Bisei, Ito Mikako, Masuda Akio, Hirakawa Akihiro, Sakai Tadahiro, Hiraiwa Hideki, Hamada Takashi, Ishiguro Naoki, Ohno Kinji

PLOS ONE   12 巻 ( 9 ) 頁： e0184388   2017年9月

SRSF1 suppresses selection of intron-distal 5 ' splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein

Bin Ahsan Khalid, Masuda Akio, Rahman Mohammad Alinoor, Takeda Jun-ichi, Nazim Mohammad, Ohkawara Bisei, Ito Mikako, Ohno Kinji

SCIENTIFIC REPORTS   7 巻 ( 1 ) 頁： 10446   2017年9月

Wnt/beta-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells

Kishimoto Yasuzumi, Ohkawara Bisei, Sakai Tadahiro, Ito Mikako, Masuda Akio, Ishiguro Naoki, Shukunami Chisa, Docheva Denitsa, Ohno Kinji

PLOS ONE   12 巻 ( 7 ) 頁： e0182051   2017年7月

Protein-Anchoring Therapy of Biglycan for Mdx Mouse Model of Duchenne Muscular Dystrophy 査読有り

Ito Mikako, Ehara Yuka, Li Jin, Inada Kosuke, Ohno Kinji

HUMAN GENE THERAPY   28 巻 ( 5 ) 頁： 428-436   2017年5月

Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms

Nazim Mohammad, Masuda Akio, Rahman Mohammad Alinoor, Nasrin Farhana, Takeda Jun-Ichi, Ohe Kenji, Ohkawara Bisei, Ito Mikako, Ohno Kinji

NUCLEIC ACIDS RESEARCH   45 巻 ( 3 ) 頁： 1455-1468   2017年2月

Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice

Hasegawa Satoru, Ito Mikako, Fukami Mayu, Hashimoto Miki, Hirayama Masaaki, Ohno Kinji

REDOX REPORT   22 巻 ( 1 ) 頁： 26-34   2017年

Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders

Ohno Kinji, Ohkawara Bisei, Ito Mikako

EXPERT OPINION ON THERAPEUTIC TARGETS   21 巻 ( 10 ) 頁： 949-958   2017年

Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling. 査読有り

Kenji Otsuka, Mikako Ito, Bisei Ohkawara, Akio Masuda, Yu Kawakami, Ko Sahashi, Hiroshi Nishida, Naoki Mabuchi, Akemi Takano, Andrew G. Engel, Kinji Ohno

Scientific Reports   5 巻 ( 13928 )   2015年9月

Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects. 査読有り

Kishimoto Y, Kato T, Ito M, Azuma Y, Fukasawa Y , Ohno K, Kojima S

J Thorac Cardiovasc Surg.   150 巻 ( 3 ) 頁： 645-54   2015年9月

A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space. 査読有り

Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K.

Neuromuscul Disord.   25 巻 ( 8 ) 頁： 667-71   2015年8月

Dopaminergic neuron-like stem cells from human deciduous teeth promote neurological recovery in Parkinsonian rats by cell replacement and paracrine neuroregenerative mechanisms 査読有り

Hiromi Fujii, Kohki Matsubara, Kiyoshi Sakai, Mikako Ito, Kinji Ohno, Minoru Ueda, Akihito Yamamoto

Brain Research   10 巻 ( 1613 ) 頁： 59-72   2015年7月

Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. 査読有り

Sobue S, Yamai K, Ito M, Ohno K, Ito M, Iwamoto T, Qiao S, Ohkuwa T, Ichihara M.

Mol Cell Biochem.   403 巻 ( 1-2 ) 頁： 231-41   2015年5月

Position-specific binding of FUS to nascent RNA regulates mRNA length. 査読有り

Masuda A., Takeda J., Okuno T., Okamoto T., Ohkawara B., Ito M., Ishigaki S., Sobue G., Ohno K.

Genes Dev.   29 巻 ( 10 ) 頁： 1045-57   2015年5月

Congenital myasthenic syndrome in Japan: ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits. 査読有り

Azuma Y, Nakata T, Tanaka M, Shen XM, Ito M, Iwata S, Okuno T, Nomura Y, Ando N, Ishigaki K, Ohkawara B, Masuda A, Natsume J, Kojima S, Sokabe M, Ohno K.

Neuromuscul Disord.   25 巻 ( 1 ) 頁： 60-9   2015年1月

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage by in utero ischemia-reperfusion 査読有り

Mano, Y. and Kotani, T. and Ito, M. and Nagai, T. and Ichinohashi, Y. and Yamada, K. and Ohno, K. and Kikkawa, F. and Toyokuni, S.

Free Radic Biol Med     頁： in press   2014年

Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia 査読有り

Matsushita, M. and Kitoh, H. and Ohkawara, B. and Mishima, K. and Kaneko, H. and Ito, M. and Masuda, A. and Ishiguro, N. and Ohno, K.

PLoS ONE   8 巻 ( 12 ) 頁： e81569   2014年

LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated musk signaling in a position-specific manner 査読有り

Ohkawara, B. and Cabrera-Serrano, M. and Nakata, T. and Milone, M. and Asai, N. and Ito, K. and Ito, M. and Masuda, A. and Ito, Y. and Engel, A. G. and Ohno, K.

Hum Mol Genet     頁： in press   2014年

Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling 査読有り

Takamatsu, A. and Ohkawara, B. and Ito, M. and Masuda, A. and Sakai, T. and Ishiguro, N. and Ohno, K.

PLOS ONE     頁： in press   2014年

Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice 査読有り

Yamamoto, R. and Matsushita, M. and Kitoh, H. and Masuda, A. and Ito, M. and Katagiri, T. and Kawai, T. and Ishiguro, N. and Ohno, K.

J Bone Miner Metab   31 巻 ( 1 ) 頁： 26-33   2013年

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells 査読有り

Iio, A. and Ito, M. and Itoh, T. and Terazawa, R. and Fujita, Y. and Nozawa, Y. and Ohsawa, I. and Ohno, K. and Ito, M.

Med Gas Res   3 巻 ( 1 ) 頁： 6   2013年

Mutations in the C-Terminal Domain of ColQ in Endplate Acetylcholinesterase Deficiency Compromise ColQ-MuSK Interaction 査読有り

Nakata, T. and Ito, M. and Azuma, Y. and Otsuka, K. and Noguchi, Y. and Komaki, H. and Okumura, A. and Shiraishi, K. and Masuda, A. and Natsume, J. and Kojima, S. and Ohno, K.

Hum Mutat   34 巻 ( 7 ) 頁： 997-1004   2013年

Collagen Q is a key player for developing rational therapy for congenital myasthenia andfor dissecting the mechanisms of anti-MuSK myasthenia gravis 査読有り

Ohno, K. and Ito, M. and Kawakami, Y.

J Mol Neurosci     頁： 3 pages   2013年

Specific binding of collagen Q to the neuromuscular junction is exploited to cure congenital myasthenia and to explore bases of myasthenia gravis 査読有り

Ohno, K. and Ito, M. and Kawakami, Y. and Krejci, E. and Engel, A. G.

Chem Biol Interact   203 巻 ( 1 ) 頁： 335-340   2013年

HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA 査読有り

Rahman, M. A. and Masuda, A. and Ohe, K. and Ito, M. and Hutchinson, D. O. and Mayeda, A. and Engel, A. G. and Ohno, K.

Sci Rep   3 巻   頁： 2931   2013年

Four parameters increase the sensitivity and specificity of the exon array analysis and disclose 25 novel aberrantly spliced exons in myotonic dystrophy 査読有り

Yamashita, Y. and Matsuura, T. and Shinmi, J. and Amakusa, Y. and Masuda, A. and Ito, M. and Kinoshita, M. and Furuya, H. and Abe, K. and Ibi, T. and Sahashi, K. and Ohno, K.

J Hum Genet   57 巻 ( 6 ) 頁： 368-74   2012年

Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats 査読有り

Ito, M. and Hirayama, M. and Yamai, K. and Goto, S. and Ito, M. and Ichihara, M. and Ohno, K.

Med Gas Res   2 巻 ( 1 ) 頁： 15   2012年

Protein-anchoring Strategy for Delivering Acetylcholinesterase to the Neuromuscular Junction 査読有り

Ito, M. and Suzuki, Y. and Okada, T. and Fukudome, T. and Yoshimura, T. and Masuda, A. and Takeda, S. and Krejci, E. and Ohno, K.

Mol Ther   20 巻 ( 7 ) 頁： 1384-92   2012年

CUGBP1 and MBNL1 preferentially bind to 3' UTRs and facilitate mRNA decay 査読有り

Masuda, A. and Andersen, H. S. and Doktor, T. K. and Okamoto, T. and Ito, M. and Andresen, B. S. and Ohno, K.

Sci Rep   2 巻   頁： 209   2012年

Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases 査読有り

Ohno, K. and Ito, M. and Ichihara, M. and Ito, M.

Oxidative Medicine and Cellular Longevity   2012(2012) 巻   頁： Article ID 353152, 11 pages   2012年

Anti-MuSK autoantibodies block binding of collagen Q to MuSK 査読有り

Kawakami, Y. and Ito, M. and Hirayama, M. and Sahashi, K. and Ohkawara, B. and Masuda, A. and Nishida, H. and Mabuchi, N. and Engel, A. G. and Ohno, K.

Neurology   77 巻 ( 20 ) 頁： 1819-26   2011年

AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon 査読有り

Fu, Y. and Masuda, A. and Ito, M. and Shinmi, J. and Ohno, K.

Nucleic Acids Research   39 巻 ( 10 ) 頁： 4396-404   2011年

Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease 査読有り

Hirayama, M. and Nakamura, T. and Watanabe, H. and Uchida, K. and Hama, T. and Hara, T. and Niimi, Y. and Ito, M. and Ohno, K. and Sobue, G.

Parkinsonism Relat Disord   17 巻 ( 1 ) 頁： 46-9   2011年

Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies 査読有り

Ito, M. and Ibi, T. and Sahashi, K. and Ichihara, M. and Ito, M. and Ohno, K.

Medical Gas Research   1 巻   頁： 24   2011年

Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages 査読有り

Itoh, T. and Hamada, N. and Terazawa, R. and Ito, M. and Ohno, K. and Ichihara, M. and Nozawa, Y. and Ito, M.

Biochem Biophys Res Commun   411 巻 ( 1 ) 頁： 143-9   2011年

Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8 査読有り

Kaneko, H. and Kitoh, H. and Matsuura, T. and Masuda, A. and Ito, M. and Mottes, M. and Rauch, F. and Ishiguro, N. and Ohno, K.

Hum Genet   130 巻 ( 5 ) 頁： 671-83   2011年

Molecular hydrogen suppresses Fc epsilon RI-mediated signal transduction and prevents degranulation of mast cells 査読有り

Itoh, T. and Fujita, Y. and Ito, M. and Masuda, A. and Ohno, K. and Ichihara, M. and Kojima, T. and Nozawa, Y. and Ito, M.

Biochemical and Biophysical Research Communications   389 巻 ( 4 ) 頁： 651-656   2009年

Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndrome 査読有り

Bian, Y. and Masuda, A. and Matsuura, T. and Ito, M. and Okushin, K. and Engel, A. G. and Ohno, K.

Hum Mol Genet   18 巻 ( 7 ) 頁： 1229-1237   2009年

Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease 査読有り

Fu, Y. and Ito, M. and Fujita, Y. and Ito, M. and Ichihara, M. and Masuda, A. and Suzuki, Y. and Maesawa, S. and Kajita, Y. and Hirayama, M. and Ohsawa, I. and Ohta, S. and Ohno, K.

Neuroscience Letters   453 巻   頁： 81–85   2009年

hnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndrome 査読有り

Masuda, A. and Shen, X. M. and Ito, M. and Matsuura, T. and Engel, A. G. and Ohno, K.

Hum Mol Genet   17 巻 ( 24 ) 頁： 4022-4035   2008年

Viral vector-medicated expression of human collagen Q in cultured cells 査読有り

Ito, M. and Masuda, A. and Jinno, S. and Katagiri, T. and Krejci, E. and Ohno, K.

Chem Biol Interact   175 巻 ( 1-3 ) 頁： 346-348   2008年

An upper limit of the ratio of DNA volume to nuclear volume exists in plants 査読有り

Fujimoto, S. and Ito, M. and Matsunaga, S. and Fukui, K.

Genes Genet Syst   80 巻 ( 5 ) 頁： 345-350   2005年

Identification and characterization of methylated DNA binding protein in Arabidopsis 査読有り

Ito, M. and Koike, A. and Yamaguchi, Y. and Koizumi, N. and Sano, H.

Plant Physiology   133 巻   頁： 1747-1754   2003年

Methylated DNA-binding proteins from Arabidopsis 査読有り

Ito, M. and Koike, A. and Koizumi, N. and Sano, H.

Plant Physiol   133 巻 ( 4 ) 頁： 1747-1754   2003年

Periodic DNA methylation in maize nucleosomes and demethylation by environmental stress 査読有り

Steward, N. and Ito, M. and Yamaguchi, Y. and Koizumi, N. and Sano, H.

J Biol Chem   277 巻 ( 40 ) 頁： 37741-37746   2002年

A chloroplast-resident DNA methyltransferase is responsible for hypermethylation of chloroplast genes in Chlamydomonas maternal gametes 査読有り

Nishiyama, R. and Ito, M. and Yamaguchi, Y. and Koizumi, N. and Sano, H.

Proc Natl Acad Sci U S A   99 巻 ( 9 ) 頁： 5925-5930   2002年

Transition between two forms of heterochromatin at plant subtelomeres 査読有り

Sykorova, E. and Fajkus, J. and Ito, M. and Fukui, K.

Chromosome Res   9 巻 ( 4 ) 頁： 309-323   2001年

Genome and Chromosome Dimensions of Lotus japonicus 査読有り

Ito, M. and Miyamoto, J. and Mori, Y. and Fujimoto, S. and Uchiumi, T. and Abe, M. and Suzuki, A. and Tabata, S. and Fukui, K.

J Plant Res   113 巻   頁： 435-442   2001年

Characterization of Spinach (Spinacia oleracea L.) Chromosomes by Condensation Patterns and Physical Mapping of 5S and 45S rDNA by FISH 査読有り

Ito, M. and Ohmido, N. and Akiyama, Y. and Fukui, K. and Koba, T.

J. Ame. Soci. Hort. Sci.   125 巻   頁： 59-62   2000年

Quantitative chromosome map of Arabidopsis thaliana L. by imaging methods 査読有り

Ito, M. and Ohmido, N. and Akiyama, Y. and Fukui, K.

Cytologia   65 巻   頁： 325-331   2000年

Adeno-associated virus serotype 8-mediated targeting of asymmetric acetylcholinesterase to the synaptic basal lamina at the neuromuscular junction 国際会議

Ito M, Suzuki Y, Okada T, Fukudome T, Masuda A, Yoshimura T, Takeda S, Krejci E, Ohno K

38th Annual Meeting, Society for Neuroscience (Poster), Washington DC, USA 

Gene Therapy for Collagen Q defects in congenital myasthenic syndromes 国際会議

Ito M, Masuda A, Jinno S, Katagiri T, Krejci E, Ohno K

The IXth International Meeting on Cholinesterases, Shuzou, China 

筋ジストロフィーにおける細胞外分子biglycan補充療法の開発

2012年 - 2013年

学内共同研究 

分子状水素による血液製剤保存法の開発及び輸血関連性肺障害の予防効果の検討

2010年8月 - 2011年3月

神経筋疾患におけるスプライシング異常

2009年9月 - 2013年3月

神経筋接合部の正常構築と分子病態研究（大野欽司）

2012年4月 - 2015年3月

科学研究費補助金  基盤研究(B)

大野欽司

重症筋無力症における抗ＭｕＳＫ抗体の認識分子同定

2011年4月 - 2013年3月

科学研究費補助金  若手研究(B)

伊藤美佳子

骨格筋細胞外分子欠損症における、組織標的シグナルを利用した汎用治療法の開発研究

2009年4月 - 2011年3月

科学研究費補助金  若手研究(B)

伊藤美佳子

神経筋接合部信号伝達障害に対するタンパク標的治療法の開発研究

2007年4月 - 2009年3月

科学研究費補助金  若手研究(B)

伊藤　美佳子

自然環境と人間

2011