Updated on 2022/08/15

写真a

 
ITO, Mikako
 
Organization
Graduate School of Medicine Center for Neurological Diseases and Cance Division Lecturer
Undergraduate School
School of Medicine Department of Medicine
Title
Lecturer
External link

Degree 1

  1. 博士(工学) ( 2001.3   大阪大学 ) 

Research Areas 1

  1. Others / Others  / Molecular Biology

Current Research Project and SDGs 2

  1. 終板アセチルコリンエステラーゼ欠損症、及び、他の細胞外マトリックス分子欠損症におけるタンパク標的療法の開発研究

  2. 筋ジストロフィーにおける細胞外分子補充療法の開発

Education 1

  1. Osaka University   Graduate School, Division of Engineering

    - 2001.3

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    Country: Japan

Professional Memberships 3

  1. The molecular biology society of Japan

  2. 日本筋学会

  3. 日本生化学会

 

Papers 82

  1. Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson's disease

    Nishiwaki Hiroshi, Ito Mikako, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Yoshida Takumi, Hanada Hiroyuki, Takeuchi Ichiro, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji

    NPJ PARKINSONS DISEASE   Vol. 8 ( 1 ) page: 65   2022.6

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  2. Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response

    Hasegawa Tomoya, Ito Mikako, Hasegawa Satoru, Teranishi Masaki, Takeda Koki, Negishi Shuto, Nishiwaki Hiroshi, Takeda Jun-ichi, LeBaron Tyler W., Ohno Kinji

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 23 ( 5 )   2022.3

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  3. Altered gut microbiota in Parkinson's disease patients with motor complications

    Takahashi Kai, Nishiwaki Hiroshi, Ito Mikako, Iwaoka Kazuhiro, Takahashi Kenta, Suzuki Yoshio, Taguchi Keita, Yamahara Kanako, Tsuboi Yoshio, Kashihara Kenichi, Hirayama Masaaki, Ohno Kinji, Maeda Tetsuya

    PARKINSONISM & RELATED DISORDERS   Vol. 95   page: 11 - 17   2022.2

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  4. Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate

    Hirayama Masaaki, Nishiwaki Hiroshi, Hamaguchi Tomonari, Ito Mikako, Ueyama Jun, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ohno Kinji

    PLOS ONE   Vol. 16 ( 11 ) page: e0260451   2021.11

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  5. Regulated splicing of large exons is linked to phase-separation of vertebrate transcription factors

    Kawachi Toshihiko, Masuda Akio, Yamashita Yoshihiro, Takeda Jun-ichi, Ohkawara Bisei, Ito Mikako, Ohno Kinji

    EMBO JOURNAL   Vol. 40 ( 22 ) page: e107485   2021.11

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  6. Plasma-activated Ringer's lactate solution inhibits the cellular respiratory system in HeLa cells

    Tanaka Hiromasa, Maeda Shogo, Nakamura Kae, Hashizume Hiroshi, Ishikawa Kenji, Ito Mikako, Ohno Kinji, Mizuno Masaaki, Motooka Yashiro, Okazaki Yasumasa, Toyokuni Shinya, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru

    PLASMA PROCESSES AND POLYMERS   Vol. 18 ( 10 )   2021.10

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    Language:Japanese  

    DOI: 10.1002/ppap.202100056

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  7. Secreted Signaling Molecules at the Neuromuscular Junction in Physiology and Pathology

    Ohkawara Bisei, Ito Mikako, Ohno Kinji

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 5 )   2021.3

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  8. Zonisamide ameliorates neuropathic pain partly by suppressing microglial activation in the spinal cord in a mouse model

    Koshimizu Hiroyuki, Ohkawara Bisei, Nakashima Hiroaki, Ota Kyotaro, Kanbara Shunsuke, Inoue Taro, Tomita Hiroyuki, Sayo Akira, Kiryu-Seo Sumiko, Konishi Hiroyuki, Ito Mikako, Masuda Akio, Ishiguro Naoki, Imagama Shiro, Kiyama Hiroshi, Ohno Kinji

    LIFE SCIENCES   Vol. 263   page: 118577   2020.12

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  9. A set of random forest models for each amino acid substitution to predict pathogenicity of missense variants in the human genome

    Takeda J., Nanatsue K., Yamagishi R., Ito M., Ohno K.

    EUROPEAN JOURNAL OF HUMAN GENETICS   Vol. 28 ( SUPPL 1 ) page: 1003 - 1003   2020.12

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    Language:Japanese  

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  10. Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage.

    Takeuchi A, Takahashi Y, Iida K, Hosokawa M, Irie K, Ito M, Brown JB, Ohno K, Nakashima K, Hagiwara M

    Stem cell reports   Vol. 15 ( 4 ) page: 883 - 897   2020.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.stemcr.2020.08.010

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  11. Gene Expression Profile at the Motor Endplate of the Neuromuscular Junction of Fast-Twitch Muscle

    Huang Kun, Li Jin, Ito Mikako, Takeda Jun-Ichi, Ohkawara Bisei, Ogi Tomoo, Masuda Akio, Ohno Kinji

    FRONTIERS IN MOLECULAR NEUROSCIENCE   Vol. 13   page: 154   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fnmol.2020.00154

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  12. Meta-Analysisof Gut Dysbiosis in Parkinson's Disease

    Nishiwaki Hiroshi, Ito Mikako, Ishida Tomohiro, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Shimamura Teppei, Mori Hiroshi, Kurokawa Ken, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji

    MOVEMENT DISORDERS   Vol. 35 ( 9 ) page: 1626 - 1635   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/mds.28119

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  13. CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction

    Ohkawara Bisei, Kobayakawa Akinori, Kanbara Shunsuke, Hattori Takako, Kubota Satoshi, Ito Mikako, Masuda Akio, Takigawa Masaharu, Lyons Karen M., Ishiguro Naoki, Ohno Kinji

    EMBO REPORTS   Vol. 21 ( 8 ) page: e48462   2020.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.15252/embr.201948462

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  14. Zonisamide ameliorates progression of cervical spondylotic myelopathy in a rat model

    Kanbara Shunsuke, Ohkawara Bisei, Nakashima Hiroaki, Ohta Kyotaro, Koshimizu Hiroyuki, Inoue Taro, Tomita Hiroyuki, Ito Mikako, Masuda Akio, Ishiguro Naoki, Imagama Shiro, Ohno Kinji

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 13138   2020.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-70068-0

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  15. InMeRF: prediction of pathogenicity of missense variants by individual modeling for each amino acid substitution

    Takeda Jun-ichi, Nanatsue Kentaro, Yamagishi Ryosuke, Ito Mikako, Haga Nobuhiko, Hirata Hiromi, Ogi Tomoo, Ohno Kinji

    NAR GENOMICS AND BIOINFORMATICS   Vol. 2 ( 2 ) page: lqaa038   2020.6

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  16. tRIP-seq reveals repression of premature polyadenylation by co-transcriptional FUS-U1 snRNP assembly

    Masuda Akio, Kawachi Toshihiko, Takeda Jun-ichi, Ohkawara Bisei, Ito Mikako, Ohno Kinji

    EMBO REPORTS   Vol. 21 ( 5 ) page: .   2020.5

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  17. Fluctuating Weak Magnetic Fields Induce Marked Mitophagy

    Toda Takuro, Ito Mikako, Mori Kaneo, Ohno Kinji

    FASEB JOURNAL   Vol. 34   2020.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fasebj.2020.34.s1.03782

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  18. Molecular Hydrogen Manages Mitochondrial Proteostatic Stress and Induces Cellular Response

    Hasegawa Tomoya, Ito Mikako, Hasegawa Satoru, Takeda Kouki, Nishiwaki Hiroshi, Negishi Shuto, Ohno Kinji

    FASEB JOURNAL   Vol. 34   2020.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fasebj.2020.34.s1.09226

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  19. SRSF3 and hnRNP K Antagonistically Regulate Splicing of Large Exons

    Kawachi Toshihiko, Masuda Akio, Takeda Jun-ichi, Ito Mikako, Hamaguchi Tomonari, Ohno Kinji

    FASEB JOURNAL   Vol. 34   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fasebj.2020.34.s1.09562

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  20. tRIP-seq reveals repression of premature polyadenylation by co-transcriptional FUS-U1 snRNP assembly

    Masuda Akio, Kawachi Toshihiko, Takeda Jun-ichi, Ohkawara Bisei, Ito Mikako, Ohno Kinji

    EMBO REPORTS   Vol. 21 ( 5 ) page: e49890   2020.3

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    DOI: 10.15252/embr.201949890

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  21. Author Correction: Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis.

      Vol. 10 ( 1 ) page: 2995   2020.2

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    DOI: 10.1038/s41598-020-60112-4

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  22. Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells

    Huang Kun, Masuda Akio, Chen Guiying, Bushra Samira, Kamon Masayoshi, Araki Toshiyuki, Kinoshita Masanobu, Ohkawara Bisei, Ito Mikako, Ohno Kinji

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 2558   2020.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-59517-y

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  23. Hydrogen water alleviates obliterative airway disease in mice

    Ozeki Naoki, Yamawaki-Ogata Aika, Narita Yuji, Mii Shinji, Ushida Kaori, Ito Mikako, Hirano Shin-ichi, Kurokawa Ryosuke, Ohno Kinji, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 68 ( 2 ) page: 158 - 163   2020.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11748-019-01195-3

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  24. Freeze-drying enables homogeneous and stable sample preparation for determination of fecal short-chain fatty acids

    Ueyama Jun, Oda Masaya, Hirayama Masaaki, Sugitate Kuniyo, Sakui Norihiro, Hamada Risa, Ito Mikako, Saito Isao, Ohno Kinji

    ANALYTICAL BIOCHEMISTRY   Vol. 589   page: 113508   2020.1

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    DOI: 10.1016/j.ab.2019.113508

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  25. Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder. Reviewed

    Nishiwaki H, Hamaguchi T, Ito M, Ishida T, Maeda T, Kashihara K, Tsuboi Y, Ueyama J, Shimamura T, Mori H, Kurokawa K, Katsuno M, Hirayama M, Ohno K.

    mSystems   Vol. 5 ( 6 ) page: e00797-20   2020

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    DOI: 10.1128/mSystems.00797-20

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  26. Mianserin suppresses R-spondin 2-induced activation of Wnt/beta-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis

    Okura Toshiaki, Ohkawara Bisei, Takegami Yasuhiko, Ito Mikako, Masuda Akio, Seki Taisuke, Ishiguro Naoki, Ohno Kinji

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 2808   2019.2

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    DOI: 10.1038/s41598-019-39393-x

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  27. Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease

    Suzuki Anzu, Ito Mikako, Hamaguchi Tomonori, Mori Hiroshi, Takeda Yuka, Baba Ryuko, Watanabe Takeshi, Kurokawa Ken, Asakawa Susumu, Hirayama Masaaki, Ohno Kinji

    PLOS ONE   Vol. 13 ( 12 ) page: e0208313   2018.12

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    DOI: 10.1371/journal.pone.0208313

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  28. Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction

    Li Jin, Ito Mikako, Ohkawara Bisei, Masuda Akio, Ohno Kinji

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 13577   2018.9

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    DOI: 10.1038/s41598-018-31949-7

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  29. Randomized, Double-Blind, Multicenter Trial of Hydrogen Water for Parkinson's Disease

    Yoritaka Asako, Ohtsuka Chigumi, Maeda Tetsuya, Hirayama Masaaki, Abe Takashi, Watanabe Hirohisa, Saiki Hidemoto, Oyama Genko, Fukae Jiro, Shimo Yasushi, Hatano Taku, Kawajiri Sumihiro, Okuma Yasuyuki, Machida Yutaka, Miwa Hideto, Suzuki Chikako, Kazama Asuka, Tomiyama Masahiko, Kihara Takeshi, Hirasawa Motoyuki, Shimura Hideki, Oda Eisei, Ito Mikako, Ohno Kinji, Hattori Nobutaka

    MOVEMENT DISORDERS   Vol. 33 ( 9 ) page: 1505 - 1507   2018.9

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  30. Protein-anchoring therapy to target extracellular matrix proteins to their physiological destinations.

    Ito M, Ohno K

    Matrix biology : journal of the International Society for Matrix Biology   Vol. 68-69   page: 628 - 636   2018.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.matbio.2018.02.014

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  31. Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain

    Takeuchi Akihide, Iida Kei, Tsubota Toshiaki, Hosokawa Motoyasu, Denawa Masatsugu, Brown J. B., Ninomiya Kensuke, Ito Mikako, Kimura Hiroshi, Abe Takaya, Kiyonari Hiroshi, Ohno Kinji, Hagiwara Masatoshi

    CELL REPORTS   Vol. 23 ( 5 ) page: 1326-1341   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2018.03.141

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  32. Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles.

    Nishiwaki H, Ito M, Negishi S, Sobue S, Ichihara M, Ohno K

    Free radical research   Vol. 52 ( 4 ) page: 434 - 445   2018

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    DOI: 10.1080/10715762.2018.1439166

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  33. Inhalation of hydrogen gas elevates urinary 8-hydroxy-2'-deoxyguanine in Parkinson's disease.

    Hirayama M, Ito M, Minato T, Yoritaka A, LeBaron TW, Ohno K

    Medical gas research   Vol. 8 ( 4 ) page: 144 - +   2018

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.4103/2045-9912.248264

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  34. Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/beta-catenin signaling

    Miyamoto Kentaro, Ohkawara Bisei, Ito Mikako, Masuda Akio, Hirakawa Akihiro, Sakai Tadahiro, Hiraiwa Hideki, Hamada Takashi, Ishiguro Naoki, Ohno Kinji

    PLOS ONE   Vol. 12 ( 9 ) page: e0184388   2017.9

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  35. SRSF1 suppresses selection of intron-distal 5 ' splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein

    Bin Ahsan Khalid, Masuda Akio, Rahman Mohammad Alinoor, Takeda Jun-ichi, Nazim Mohammad, Ohkawara Bisei, Ito Mikako, Ohno Kinji

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 10446   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-11036-z

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  36. Wnt/beta-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells

    Kishimoto Yasuzumi, Ohkawara Bisei, Sakai Tadahiro, Ito Mikako, Masuda Akio, Ishiguro Naoki, Shukunami Chisa, Docheva Denitsa, Ohno Kinji

    PLOS ONE   Vol. 12 ( 7 ) page: e0182051   2017.7

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    DOI: 10.1371/journal.pone.0182051

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  37. Protein-Anchoring Therapy of Biglycan for Mdx Mouse Model of Duchenne Muscular Dystrophy Reviewed

    Ito Mikako, Ehara Yuka, Li Jin, Inada Kosuke, Ohno Kinji

    HUMAN GENE THERAPY   Vol. 28 ( 5 ) page: 428-436   2017.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/hum.2015.088

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  38. Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms

    Nazim Mohammad, Masuda Akio, Rahman Mohammad Alinoor, Nasrin Farhana, Takeda Jun-Ichi, Ohe Kenji, Ohkawara Bisei, Ito Mikako, Ohno Kinji

    NUCLEIC ACIDS RESEARCH   Vol. 45 ( 3 ) page: 1455-1468   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkw823

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  39. Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice

    Hasegawa Satoru, Ito Mikako, Fukami Mayu, Hashimoto Miki, Hirayama Masaaki, Ohno Kinji

    REDOX REPORT   Vol. 22 ( 1 ) page: 26-34   2017

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    DOI: 10.1080/13510002.2015.1135580

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  40. Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders

    Ohno Kinji, Ohkawara Bisei, Ito Mikako

    EXPERT OPINION ON THERAPEUTIC TARGETS   Vol. 21 ( 10 ) page: 949-958   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14728222.2017.1369960

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  41. Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling. Reviewed

    Kenji Otsuka, Mikako Ito, Bisei Ohkawara, Akio Masuda, Yu Kawakami, Ko Sahashi, Hiroshi Nishida, Naoki Mabuchi, Akemi Takano, Andrew G. Engel, Kinji Ohno

    Scientific Reports   Vol. 5 ( 13928 )   2015.9

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    DOI: 10.1038/srep13928.

  42. Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects. Reviewed

    Kishimoto Y, Kato T, Ito M, Azuma Y, Fukasawa Y , Ohno K, Kojima S

    J Thorac Cardiovasc Surg.   Vol. 150 ( 3 ) page: 645-54   2015.9

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  43. A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space. Reviewed

    Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K.

    Neuromuscul Disord.   Vol. 25 ( 8 ) page: 667-71   2015.8

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    DOI: 10.1016/j.nmd.2015.05.002

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  44. Dopaminergic neuron-like stem cells from human deciduous teeth promote neurological recovery in Parkinsonian rats by cell replacement and paracrine neuroregenerative mechanisms Reviewed

    Hiromi Fujii, Kohki Matsubara, Kiyoshi Sakai, Mikako Ito, Kinji Ohno, Minoru Ueda, Akihito Yamamoto

    Brain Research   Vol. 10 ( 1613 ) page: 59-72   2015.7

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  45. Position-specific binding of FUS to nascent RNA regulates mRNA length. Reviewed

    Masuda A., Takeda J., Okuno T., Okamoto T., Ohkawara B., Ito M., Ishigaki S., Sobue G., Ohno K.

    Genes Dev.   Vol. 29 ( 10 ) page: 1045-57   2015.5

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    DOI: 10.1101/gad.255737.114.

  46. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Reviewed

    Sobue S, Yamai K, Ito M, Ohno K, Ito M, Iwamoto T, Qiao S, Ohkuwa T, Ichihara M.

    Mol Cell Biochem.   Vol. 403 ( 1-2 ) page: 231-41   2015.5

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    DOI: 10.1007/s11010-015-2353-y

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  47. Congenital myasthenic syndrome in Japan: ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits. Reviewed

    Azuma Y, Nakata T, Tanaka M, Shen XM, Ito M, Iwata S, Okuno T, Nomura Y, Ando N, Ishigaki K, Ohkawara B, Masuda A, Natsume J, Kojima S, Sokabe M, Ohno K.

    Neuromuscul Disord.   Vol. 25 ( 1 ) page: 60-9   2015.1

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    DOI: 10.1016/j.nmd.2014.09.002.

  48. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage by in utero ischemia-reperfusion Reviewed

    Mano, Y. and Kotani, T. and Ito, M. and Nagai, T. and Ichinohashi, Y. and Yamada, K. and Ohno, K. and Kikkawa, F. and Toyokuni, S.

    Free Radic Biol Med     page: in press   2014

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  49. Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia Reviewed

    Matsushita, M. and Kitoh, H. and Ohkawara, B. and Mishima, K. and Kaneko, H. and Ito, M. and Masuda, A. and Ishiguro, N. and Ohno, K.

    PLoS ONE   Vol. 8 ( 12 ) page: e81569   2014

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  50. LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated musk signaling in a position-specific manner Reviewed

    Ohkawara, B. and Cabrera-Serrano, M. and Nakata, T. and Milone, M. and Asai, N. and Ito, K. and Ito, M. and Masuda, A. and Ito, Y. and Engel, A. G. and Ohno, K.

    Hum Mol Genet     page: in press   2014

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  51. Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling Reviewed

    Takamatsu, A. and Ohkawara, B. and Ito, M. and Masuda, A. and Sakai, T. and Ishiguro, N. and Ohno, K.

    PLOS ONE     page: in press   2014

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  52. Mutations in the C-Terminal Domain of ColQ in Endplate Acetylcholinesterase Deficiency Compromise ColQ-MuSK Interaction Reviewed

    Nakata, T. and Ito, M. and Azuma, Y. and Otsuka, K. and Noguchi, Y. and Komaki, H. and Okumura, A. and Shiraishi, K. and Masuda, A. and Natsume, J. and Kojima, S. and Ohno, K.

    Hum Mutat   Vol. 34 ( 7 ) page: 997-1004   2013

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  53. Collagen Q is a key player for developing rational therapy for congenital myasthenia andfor dissecting the mechanisms of anti-MuSK myasthenia gravis Reviewed

    Ohno, K. and Ito, M. and Kawakami, Y.

    J Mol Neurosci     page: 3 pages   2013

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  54. Specific binding of collagen Q to the neuromuscular junction is exploited to cure congenital myasthenia and to explore bases of myasthenia gravis Reviewed

    Ohno, K. and Ito, M. and Kawakami, Y. and Krejci, E. and Engel, A. G.

    Chem Biol Interact   Vol. 203 ( 1 ) page: 335-340   2013

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  55. HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA Reviewed

    Rahman, M. A. and Masuda, A. and Ohe, K. and Ito, M. and Hutchinson, D. O. and Mayeda, A. and Engel, A. G. and Ohno, K.

    Sci Rep   Vol. 3   page: 2931   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

  56. Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice Reviewed

    Yamamoto, R. and Matsushita, M. and Kitoh, H. and Masuda, A. and Ito, M. and Katagiri, T. and Kawai, T. and Ishiguro, N. and Ohno, K.

    J Bone Miner Metab   Vol. 31 ( 1 ) page: 26-33   2013

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  57. Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells Reviewed

    Iio, A. and Ito, M. and Itoh, T. and Terazawa, R. and Fujita, Y. and Nozawa, Y. and Ohsawa, I. and Ohno, K. and Ito, M.

    Med Gas Res   Vol. 3 ( 1 ) page: 6   2013

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  58. Protein-anchoring Strategy for Delivering Acetylcholinesterase to the Neuromuscular Junction Reviewed

    Ito, M. and Suzuki, Y. and Okada, T. and Fukudome, T. and Yoshimura, T. and Masuda, A. and Takeda, S. and Krejci, E. and Ohno, K.

    Mol Ther   Vol. 20 ( 7 ) page: 1384-92   2012

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  59. CUGBP1 and MBNL1 preferentially bind to 3' UTRs and facilitate mRNA decay Reviewed

    Masuda, A. and Andersen, H. S. and Doktor, T. K. and Okamoto, T. and Ito, M. and Andresen, B. S. and Ohno, K.

    Sci Rep   Vol. 2   page: 209   2012

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  60. Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases Reviewed

    Ohno, K. and Ito, M. and Ichihara, M. and Ito, M.

    Oxidative Medicine and Cellular Longevity   Vol. 2012(2012)   page: Article ID 353152, 11 pages   2012

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  61. Four parameters increase the sensitivity and specificity of the exon array analysis and disclose 25 novel aberrantly spliced exons in myotonic dystrophy Reviewed

    Yamashita, Y. and Matsuura, T. and Shinmi, J. and Amakusa, Y. and Masuda, A. and Ito, M. and Kinoshita, M. and Furuya, H. and Abe, K. and Ibi, T. and Sahashi, K. and Ohno, K.

    J Hum Genet   Vol. 57 ( 6 ) page: 368-74   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

  62. Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats Reviewed

    Ito, M. and Hirayama, M. and Yamai, K. and Goto, S. and Ito, M. and Ichihara, M. and Ohno, K.

    Med Gas Res   Vol. 2 ( 1 ) page: 15   2012

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  63. Anti-MuSK autoantibodies block binding of collagen Q to MuSK Reviewed

    Kawakami, Y. and Ito, M. and Hirayama, M. and Sahashi, K. and Ohkawara, B. and Masuda, A. and Nishida, H. and Mabuchi, N. and Engel, A. G. and Ohno, K.

    Neurology   Vol. 77 ( 20 ) page: 1819-26   2011

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  64. Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages Reviewed

    Itoh, T. and Hamada, N. and Terazawa, R. and Ito, M. and Ohno, K. and Ichihara, M. and Nozawa, Y. and Ito, M.

    Biochem Biophys Res Commun   Vol. 411 ( 1 ) page: 143-9   2011

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  65. Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8 Reviewed

    Kaneko, H. and Kitoh, H. and Matsuura, T. and Masuda, A. and Ito, M. and Mottes, M. and Rauch, F. and Ishiguro, N. and Ohno, K.

    Hum Genet   Vol. 130 ( 5 ) page: 671-83   2011

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  66. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies Reviewed

    Ito, M. and Ibi, T. and Sahashi, K. and Ichihara, M. and Ito, M. and Ohno, K.

    Medical Gas Research   Vol. 1   page: 24   2011

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  67. AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon Reviewed

    Fu, Y. and Masuda, A. and Ito, M. and Shinmi, J. and Ohno, K.

    Nucleic Acids Research   Vol. 39 ( 10 ) page: 4396-404   2011

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  68. Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease Reviewed

    Hirayama, M. and Nakamura, T. and Watanabe, H. and Uchida, K. and Hama, T. and Hara, T. and Niimi, Y. and Ito, M. and Ohno, K. and Sobue, G.

    Parkinsonism Relat Disord   Vol. 17 ( 1 ) page: 46-9   2011

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  69. Molecular hydrogen suppresses Fc epsilon RI-mediated signal transduction and prevents degranulation of mast cells Reviewed

    Itoh, T. and Fujita, Y. and Ito, M. and Masuda, A. and Ohno, K. and Ichihara, M. and Kojima, T. and Nozawa, Y. and Ito, M.

    Biochemical and Biophysical Research Communications   Vol. 389 ( 4 ) page: 651-656   2009

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  70. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease Reviewed

    Fu, Y. and Ito, M. and Fujita, Y. and Ito, M. and Ichihara, M. and Masuda, A. and Suzuki, Y. and Maesawa, S. and Kajita, Y. and Hirayama, M. and Ohsawa, I. and Ohta, S. and Ohno, K.

    Neuroscience Letters   Vol. 453   page: 81–85   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

  71. Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndrome Reviewed

    Bian, Y. and Masuda, A. and Matsuura, T. and Ito, M. and Okushin, K. and Engel, A. G. and Ohno, K.

    Hum Mol Genet   Vol. 18 ( 7 ) page: 1229-1237   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

  72. hnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndrome Reviewed

    Masuda, A. and Shen, X. M. and Ito, M. and Matsuura, T. and Engel, A. G. and Ohno, K.

    Hum Mol Genet   Vol. 17 ( 24 ) page: 4022-4035   2008

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  73. Viral vector-medicated expression of human collagen Q in cultured cells Reviewed

    Ito, M. and Masuda, A. and Jinno, S. and Katagiri, T. and Krejci, E. and Ohno, K.

    Chem Biol Interact   Vol. 175 ( 1-3 ) page: 346-348   2008

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  74. An upper limit of the ratio of DNA volume to nuclear volume exists in plants Reviewed

    Fujimoto, S. and Ito, M. and Matsunaga, S. and Fukui, K.

    Genes Genet Syst   Vol. 80 ( 5 ) page: 345-350   2005

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  75. Identification and characterization of methylated DNA binding protein in Arabidopsis Reviewed

    Ito, M. and Koike, A. and Yamaguchi, Y. and Koizumi, N. and Sano, H.

    Plant Physiology   Vol. 133   page: 1747-1754   2003

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  76. Methylated DNA-binding proteins from Arabidopsis Reviewed

    Ito, M. and Koike, A. and Koizumi, N. and Sano, H.

    Plant Physiol   Vol. 133 ( 4 ) page: 1747-1754   2003

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  77. Periodic DNA methylation in maize nucleosomes and demethylation by environmental stress Reviewed

    Steward, N. and Ito, M. and Yamaguchi, Y. and Koizumi, N. and Sano, H.

    J Biol Chem   Vol. 277 ( 40 ) page: 37741-37746   2002

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  78. A chloroplast-resident DNA methyltransferase is responsible for hypermethylation of chloroplast genes in Chlamydomonas maternal gametes Reviewed

    Nishiyama, R. and Ito, M. and Yamaguchi, Y. and Koizumi, N. and Sano, H.

    Proc Natl Acad Sci U S A   Vol. 99 ( 9 ) page: 5925-5930   2002

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  79. Transition between two forms of heterochromatin at plant subtelomeres Reviewed

    Sykorova, E. and Fajkus, J. and Ito, M. and Fukui, K.

    Chromosome Res   Vol. 9 ( 4 ) page: 309-323   2001

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  80. Genome and Chromosome Dimensions of Lotus japonicus Reviewed

    Ito, M. and Miyamoto, J. and Mori, Y. and Fujimoto, S. and Uchiumi, T. and Abe, M. and Suzuki, A. and Tabata, S. and Fukui, K.

    J Plant Res   Vol. 113   page: 435-442   2001

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  81. Characterization of Spinach (Spinacia oleracea L.) Chromosomes by Condensation Patterns and Physical Mapping of 5S and 45S rDNA by FISH Reviewed

    Ito, M. and Ohmido, N. and Akiyama, Y. and Fukui, K. and Koba, T.

    J. Ame. Soci. Hort. Sci.   Vol. 125   page: 59-62   2000

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  82. Quantitative chromosome map of Arabidopsis thaliana L. by imaging methods Reviewed

    Ito, M. and Ohmido, N. and Akiyama, Y. and Fukui, K.

    Cytologia   Vol. 65   page: 325-331   2000

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Books 3

  1. 生物の科学遺伝 63ー5 タンパク質係留治療

    大野欽司,伊藤美佳子( Role: Sole author)

    エヌ・ティー・エス  2009.9  ( ISBN:4860432819

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    Language:Japanese Book type:Scholarly book

  2. 「クロモソーム植物染色体研究の方法」福井希一、向井康比己、谷口研至編著 アラビドプシスにおける染色体観察方法

    伊藤美佳子( Role: Joint author)

    養賢堂  2006 

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    Language:Japanese

  3. 植物細胞工学シリーズ13「植物細胞の分裂」町田康則、福田泰穂監修 シロイヌナズナ染色体の識別・同定

    伊藤美佳子 福井希一( Role: Joint author)

    秀潤社  2000 

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    Language:Japanese

Presentations 7

  1. Protein-anchoring therapy for delivering acetylcholinesterase to the neuromuscular junction International conference

    Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K

    11th International Meeting on Cholinesterases (Poster), Kazan, Russia 

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    Event date: 2012.6

    Language:English   Presentation type:Poster presentation  

    Country:Russian Federation  

  2. Protein-anchoring therapy For delivering acetylcholinesterase to the neuromuscular junction International conference

    Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K

    17th Annual Meeting of the Japan Society of Gene Therapy (Poster), Fukuoka, Japan 

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    Event date: 2011.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  3. 分子状水素はパーキンソン病モデルラットの発症を抑制し、ヒト筋疾患の各種マーカーを改善する

    伊藤 美佳子、付 源、衣斐 達、大野 欽司

    日本分子生物学会 神戸 ワークショップ 

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    Event date: 2010.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  4. rAAV8-Mediated Protein-Anchoring Therapy for Targeting Collagen Q-Tailed Acetylcholinesterase to the Neuromuscular Junction International conference

    Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K

    American Society of Gene & Cell Therapy 13th Annual Meeting (Platform), Washington DC, USA 

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    Event date: 2010.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  5. rAAV8-mediated protein anchoring of asymmetric acetylcholinesterase (AChE) to the synaptic basal lamina at the neuromuscular junction (NMJ) International conference

    Ito M, Suzuki Y, Okada T, Fukudome T, Masuda A, Yoshimura T, Takeda S, Krejci E, Ohno K

    48th Annual Meeting of the American Society for Cell Biology (Poster), San Francisco, San Diego, California, USA 

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    Event date: 2008.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  6. Adeno-associated virus serotype 8-mediated targeting of asymmetric acetylcholinesterase to the synaptic basal lamina at the neuromuscular junction International conference

    Ito M, Suzuki Y, Okada T, Fukudome T, Masuda A, Yoshimura T, Takeda S, Krejci E, Ohno K

    38th Annual Meeting, Society for Neuroscience (Poster), Washington DC, USA 

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    Event date: 2008.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  7. Gene Therapy for Collagen Q defects in congenital myasthenic syndromes International conference

    Ito M, Masuda A, Jinno S, Katagiri T, Krejci E, Ohno K

    The IXth International Meeting on Cholinesterases, Shuzou, China 

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    Event date: 2007.5

    Language:English   Presentation type:Poster presentation  

    Country:China  

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Research Project for Joint Research, Competitive Funding, etc. 8

  1. 先天性筋無力症候群における分子病態の解明と新規治療法の開発

    2019.4 - 2020.3

    学内共同研究 

  2. iPS 細胞を用いた先天性筋無力症候群の病態解析および新規治療法の開発

    2019.4 - 2020.3

    学内共同研究 

  3. 腸内細菌叢の変動によるパーキンソン病発症機序の解明と発症抑制・病態進行抑制法の開発

    2018.4 - 2019.3

    学内共同研究 

  4. パーキンソン病患者の腸内細菌層(マイクロバイオーム)解析による病態解明

    2016.4 - 2017.4

    学内共同研究 

  5. パーキンソン病の発症と病態進行に関わる腸内細菌叢の解明

    2015.10 - 2016.9

    学内共同研究 

  6. 筋ジストロフィーにおける細胞外分子biglycan補充療法の開発

    2012 - 2013

    学内共同研究 

  7. 分子状水素による血液製剤保存法の開発及び輸血関連性肺障害の予防効果の検討

    2010.8 - 2011.3

  8. Aberrant splicing in neuromuscular diseases

    2009.9 - 2013.3

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KAKENHI (Grants-in-Aid for Scientific Research) 9

  1. 肢帯型先天性筋無力症の病態解析および新規治療法の開発

    2020.4 - 2023.3

    科学研究費補助金  基盤研究(C)

    伊藤 美佳子

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    Authorship:Principal investigator 

    先天的な神経筋接合部の分子欠損による先天性筋無力症候群 (CMS: congenital myasthenic syndromes,)は筋力低下や易疲労性を呈し、軽度から重度の呼吸困難、嚥下困難、四肢筋力低 下が認められるが、その分子病態は十分解明されていない。本研究では神経筋接合部の分 子構築機構の解明と、CMS患者由来iPS細胞を用いたGFPT1(Glutamine fructose-6-phosphate aminotransferase)、DOK7の遺伝子変異の機能解析を行い、既認可薬からスクリーニングに よる新規治療法の開発に取り組む。本邦のCMSの確定診断例は極めて少なく未診断例・誤 診断例が数多く存在することが予想され、遺伝子変異を同定できないCMSも多く存在す る。患者由来のiPS細胞由来筋管細胞・神経筋接合部を用いたアンチセンスオリゴおよび ドラッグ・リポジショニング戦略により、ベンチトップ研究成果の迅􏰁な臨床への応用が 可能であることが期待される。

  2. Pathological analysis of limb girdle congenital myasthenia and development of new therapy

    Grant number:20K06925  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  3. Pathological analysis of GFPT1 congenital myasthenia and development of new therapy using iPS cells.

    Grant number:17K07094  2017.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ito Mikako

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    Authorship:Principal investigator 

    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    One of the causative molecules of congenital myasthesis syndrome (CMS) is a mutation in GFPT1, a glycosylation enzyme of proteins and lipids, which is characterized by limb-type muscle weakness. GFPT1-L isoform is formed in skeletal muscle and enzyme activity is reduced. In this study, in order to clarify the role of GFPT1-L in skeletal muscle, model mouse Gfpt1-L-/-was prepared and phenotypic analysis was performed.
    In addition, we identified the GFPT1 c.722 ^ 723insG mutation in CMS patients and prepared a model mouse of the mutation. The mice were decreased motor function, decreased amount of glycosylated protein, fragmentation of AChR cluster, muscle atrophy, and increased interstitial space. of muscle fiber. It showed a patient-like phenotype.

  4. iPS細胞を用いたGFPT1先天性筋無力症の病態解析および治療研究

    2017.4 - 2020.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  5. 筋ジストロフィーにおける細胞外分子補充療法の開発

    2013.4 - 2017.3

    科学研究費補助金  基盤研究(C)

    伊藤美佳子

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    Authorship:Principal investigator 

  6. 神経筋接合部の正常構築と分子病態研究(大野欽司)

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(B)

    大野欽司

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    Authorship:Coinvestigator(s) 

  7. 重症筋無力症における抗MuSK抗体の認識分子同定

    2011.4 - 2013.3

    科学研究費補助金  若手研究(B)

    伊藤美佳子

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    Authorship:Principal investigator 

  8. 骨格筋細胞外分子欠損症における、組織標的シグナルを利用した汎用治療法の開発研究

    2009.4 - 2011.3

    科学研究費補助金  若手研究(B)

    伊藤美佳子

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    Authorship:Principal investigator 

  9. 神経筋接合部信号伝達障害に対するタンパク標的治療法の開発研究

    2007.4 - 2009.3

    科学研究費補助金  若手研究(B)

    伊藤 美佳子

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 4

  1. 生物学基礎II

    2021

  2. 生物学基礎II

    2020

  3. 自然環境と人間

    2015

  4. 自然環境と人間

    2011