Updated on 2023/03/14
博士（工学） （ 2001.3 大阪大学 ）
神経筋接合部 先天性筋無力症候群 分子状水素 微弱磁場
Others / Others / Molecular Biology
終板アセチルコリンエステラーゼ欠損症、及び、他の細胞外マトリックス分子欠損症におけるタンパク標的療法の開発研究
筋ジストロフィーにおける細胞外分子補充療法の開発
Osaka University Graduate School, Division of Engineering
- 2001.3
Country： Japan
The molecular biology society of Japan
日本筋学会
日本生化学会
A mutation in DOK7 in congenital myasthenic syndrome forms aggresome in cultured cells, and reduces DOK7 expression and MuSK phosphorylation in patient-derived iPS cells.
Zhang S, Ohkawara B, Ito M, Huang Z, Zhao F, Nakata T, Takeuchi T, Sakurai H, Komaki H, Kamon M, Araki T, Ohno K
Human molecular genetics 2022.12
Effects of Pesticide Intake on Gut Microbiota and Metabolites in Healthy Adults.
Ueyama J, Hayashi M, Hirayama M, Nishiwaki H, Ito M, Saito I, Tsuboi Y, Isobe T, Ohno K
International journal of environmental research and public health Vol. 20 ( 1 ) 2022.12
Gut microbiota in dementia with Lewy bodies.
Nishiwaki H, Ueyama J, Kashihara K, Ito M, Hamaguchi T, Maeda T, Tsuboi Y, Katsuno M, Hirayama M, Ohno K
NPJ Parkinson's disease Vol. 8 ( 1 ) page： 169 2022.12
Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative Colitis.
Gibo N, Hamaguchi T, Miki Y, Yamamura T, Nakaguro M, Ito M, Nakamuara M, Kawashima H, Hirayama M, Hirooka Y, Wakabayashi K, Ohno K
Journal of gastrointestinal and liver diseases : JGLD Vol. 31 ( 3 ) page： 290 - 300 2022.9
Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson's disease
Nishiwaki Hiroshi, Ito Mikako, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Yoshida Takumi, Hanada Hiroyuki, Takeuchi Ichiro, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji
NPJ PARKINSONS DISEASE Vol. 8 ( 1 ) page： 65 2022.6
Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria Reviewed
Takuro Toda; Mikako Ito; Jun-ichi Takeda; Akio Masuda; Hiroyuki Mino; Nobutaka Hattori; Kaneo Mohri; Kinji Ohno
Communications Biology Vol. 5 page： 453 2022.5
Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response
Hasegawa Tomoya, Ito Mikako, Hasegawa Satoru, Teranishi Masaki, Takeda Koki, Negishi Shuto, Nishiwaki Hiroshi, Takeda Jun-ichi, LeBaron Tyler W., Ohno Kinji
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 23 ( 5 ) 2022.3
Altered gut microbiota in Parkinson's disease patients with motor complications
Takahashi Kai, Nishiwaki Hiroshi, Ito Mikako, Iwaoka Kazuhiro, Takahashi Kenta, Suzuki Yoshio, Taguchi Keita, Yamahara Kanako, Tsuboi Yoshio, Kashihara Kenichi, Hirayama Masaaki, Ohno Kinji, Maeda Tetsuya
PARKINSONISM & RELATED DISORDERS Vol. 95 page： 11 - 17 2022.2
Enhancement of ethanol production and cell growth in budding yeast by direct irradiation of low-temperature plasma
Tanaka Hiromasa, Matsumura Shogo, Ishikawa Kenji, Hashizume Hiroshi, Ito Masafumi, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Ito Mikako, Ohno Kinji, Okazaki Yasumasa, Toyokuni Shinya, Mizuno Masaaki, Hori Masaru
JAPANESE JOURNAL OF APPLIED PHYSICS Vol. 61 ( SA ) 2022.1
Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate
Hirayama Masaaki, Nishiwaki Hiroshi, Hamaguchi Tomonari, Ito Mikako, Ueyama Jun, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ohno Kinji
PLOS ONE Vol. 16 ( 11 ) page： e0260451 2021.11
Regulated splicing of large exons is linked to phase-separation of vertebrate transcription factors
Kawachi Toshihiko, Masuda Akio, Yamashita Yoshihiro, Takeda Jun-ichi, Ohkawara Bisei, Ito Mikako, Ohno Kinji
EMBO JOURNAL Vol. 40 ( 22 ) page： e107485 2021.11
Plasma-activated Ringer's lactate solution inhibits the cellular respiratory system in HeLa cells
Tanaka Hiromasa, Maeda Shogo, Nakamura Kae, Hashizume Hiroshi, Ishikawa Kenji, Ito Mikako, Ohno Kinji, Mizuno Masaaki, Motooka Yashiro, Okazaki Yasumasa, Toyokuni Shinya, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru
PLASMA PROCESSES AND POLYMERS Vol. 18 ( 10 ) 2021.10
Secreted Signaling Molecules at the Neuromuscular Junction in Physiology and Pathology
Ohkawara Bisei, Ito Mikako, Ohno Kinji
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 22 ( 5 ) 2021.3
Zonisamide ameliorates neuropathic pain partly by suppressing microglial activation in the spinal cord in a mouse model
Koshimizu Hiroyuki, Ohkawara Bisei, Nakashima Hiroaki, Ota Kyotaro, Kanbara Shunsuke, Inoue Taro, Tomita Hiroyuki, Sayo Akira, Kiryu-Seo Sumiko, Konishi Hiroyuki, Ito Mikako, Masuda Akio, Ishiguro Naoki, Imagama Shiro, Kiyama Hiroshi, Ohno Kinji
LIFE SCIENCES Vol. 263 page： 118577 2020.12
A set of random forest models for each amino acid substitution to predict pathogenicity of missense variants in the human genome
Takeda J., Nanatsue K., Yamagishi R., Ito M., Ohno K.
EUROPEAN JOURNAL OF HUMAN GENETICS Vol. 28 ( SUPPL 1 ) page： 1003 - 1003 2020.12
Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage.
Takeuchi A, Takahashi Y, Iida K, Hosokawa M, Irie K, Ito M, Brown JB, Ohno K, Nakashima K, Hagiwara M
Stem cell reports Vol. 15 ( 4 ) page： 883 - 897 2020.10
Gene Expression Profile at the Motor Endplate of the Neuromuscular Junction of Fast-Twitch Muscle
Huang Kun, Li Jin, Ito Mikako, Takeda Jun-Ichi, Ohkawara Bisei, Ogi Tomoo, Masuda Akio, Ohno Kinji
FRONTIERS IN MOLECULAR NEUROSCIENCE Vol. 13 page： 154 2020.9
Meta-Analysisof Gut Dysbiosis in Parkinson's Disease
Nishiwaki Hiroshi, Ito Mikako, Ishida Tomohiro, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Shimamura Teppei, Mori Hiroshi, Kurokawa Ken, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji
MOVEMENT DISORDERS Vol. 35 ( 9 ) page： 1626 - 1635 2020.9
CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction
Ohkawara Bisei, Kobayakawa Akinori, Kanbara Shunsuke, Hattori Takako, Kubota Satoshi, Ito Mikako, Masuda Akio, Takigawa Masaharu, Lyons Karen M., Ishiguro Naoki, Ohno Kinji
EMBO REPORTS Vol. 21 ( 8 ) page： e48462 2020.8
Zonisamide ameliorates progression of cervical spondylotic myelopathy in a rat model
Kanbara Shunsuke, Ohkawara Bisei, Nakashima Hiroaki, Ohta Kyotaro, Koshimizu Hiroyuki, Inoue Taro, Tomita Hiroyuki, Ito Mikako, Masuda Akio, Ishiguro Naoki, Imagama Shiro, Ohno Kinji
SCIENTIFIC REPORTS Vol. 10 ( 1 ) page： 13138 2020.8
InMeRF: prediction of pathogenicity of missense variants by individual modeling for each amino acid substitution
Takeda Jun-ichi, Nanatsue Kentaro, Yamagishi Ryosuke, Ito Mikako, Haga Nobuhiko, Hirata Hiromi, Ogi Tomoo, Ohno Kinji
NAR GENOMICS AND BIOINFORMATICS Vol. 2 ( 2 ) page： lqaa038 2020.6
tRIP-seq reveals repression of premature polyadenylation by co-transcriptional FUS-U1 snRNP assembly
Masuda Akio, Kawachi Toshihiko, Takeda Jun-ichi, Ohkawara Bisei, Ito Mikako, Ohno Kinji
EMBO REPORTS Vol. 21 ( 5 ) page： e49890 2020.5
tRIP-seq reveals repression of premature polyadenylation by co-transcriptional FUS-U1 snRNP assembly
Masuda Akio, Kawachi Toshihiko, Takeda Jun-ichi, Ohkawara Bisei, Ito Mikako, Ohno Kinji
EMBO REPORTS Vol. 21 ( 5 ) page： . 2020.5
Fluctuating Weak Magnetic Fields Induce Marked Mitophagy
Toda Takuro, Ito Mikako, Mori Kaneo, Ohno Kinji
FASEB JOURNAL Vol. 34 2020.4
Molecular Hydrogen Manages Mitochondrial Proteostatic Stress and Induces Cellular Response
Hasegawa Tomoya, Ito Mikako, Hasegawa Satoru, Takeda Kouki, Nishiwaki Hiroshi, Negishi Shuto, Ohno Kinji
FASEB JOURNAL Vol. 34 2020.4
SRSF3 and hnRNP K Antagonistically Regulate Splicing of Large Exons
Kawachi Toshihiko, Masuda Akio, Takeda Jun-ichi, Ito Mikako, Hamaguchi Tomonari, Ohno Kinji
FASEB JOURNAL Vol. 34 2020.4
Mianserin suppresses R-spondin 2-induced activation of Wnt/beta-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis (vol 12, 4512, 2019)
Okura Toshiaki, Ohkawara Bisei, Takegami Yasuhiko, Ito Mikako, Masuda Akio, Seki Taisuke, Ishiguro Naoki, Ohno Kinji
SCIENTIFIC REPORTS Vol. 10 ( 1 ) page： 2995 2020.2
Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells
Huang Kun, Masuda Akio, Chen Guiying, Bushra Samira, Kamon Masayoshi, Araki Toshiyuki, Kinoshita Masanobu, Ohkawara Bisei, Ito Mikako, Ohno Kinji
SCIENTIFIC REPORTS Vol. 10 ( 1 ) page： 2558 2020.2
Hydrogen water alleviates obliterative airway disease in mice
Ozeki Naoki, Yamawaki-Ogata Aika, Narita Yuji, Mii Shinji, Ushida Kaori, Ito Mikako, Hirano Shin-ichi, Kurokawa Ryosuke, Ohno Kinji, Usui Akihiko
GENERAL THORACIC AND CARDIOVASCULAR SURGERY Vol. 68 ( 2 ) page： 158 - 163 2020.2
Freeze-drying enables homogeneous and stable sample preparation for determination of fecal short-chain fatty acids
Ueyama Jun, Oda Masaya, Hirayama Masaaki, Sugitate Kuniyo, Sakui Norihiro, Hamada Risa, Ito Mikako, Saito Isao, Ohno Kinji
ANALYTICAL BIOCHEMISTRY Vol. 589 page： 113508 2020.1
Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder. Reviewed
Nishiwaki H, Hamaguchi T, Ito M, Ishida T, Maeda T, Kashihara K, Tsuboi Y, Ueyama J, Shimamura T, Mori H, Kurokawa K, Katsuno M, Hirayama M, Ohno K.
mSystems Vol. 5 ( 6 ) page： e00797-20 2020
Mianserin suppresses R-spondin 2-induced activation of Wnt/beta-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis
Okura Toshiaki, Ohkawara Bisei, Takegami Yasuhiko, Ito Mikako, Masuda Akio, Seki Taisuke, Ishiguro Naoki, Ohno Kinji
SCIENTIFIC REPORTS Vol. 9 ( 1 ) page： 2808 2019.2
Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease
Suzuki Anzu, Ito Mikako, Hamaguchi Tomonori, Mori Hiroshi, Takeda Yuka, Baba Ryuko, Watanabe Takeshi, Kurokawa Ken, Asakawa Susumu, Hirayama Masaaki, Ohno Kinji
PLOS ONE Vol. 13 ( 12 ) page： e0208313 2018.12
Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction
Li Jin, Ito Mikako, Ohkawara Bisei, Masuda Akio, Ohno Kinji
SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 13577 2018.9
Randomized, Double-Blind, Multicenter Trial of Hydrogen Water for Parkinson's Disease
Yoritaka Asako, Ohtsuka Chigumi, Maeda Tetsuya, Hirayama Masaaki, Abe Takashi, Watanabe Hirohisa, Saiki Hidemoto, Oyama Genko, Fukae Jiro, Shimo Yasushi, Hatano Taku, Kawajiri Sumihiro, Okuma Yasuyuki, Machida Yutaka, Miwa Hideto, Suzuki Chikako, Kazama Asuka, Tomiyama Masahiko, Kihara Takeshi, Hirasawa Motoyuki, Shimura Hideki, Oda Eisei, Ito Mikako, Ohno Kinji, Hattori Nobutaka
MOVEMENT DISORDERS Vol. 33 ( 9 ) page： 1505 - 1507 2018.9
Protein-anchoring therapy to target extracellular matrix proteins to their physiological destinations.
Ito M, Ohno K
Matrix biology : journal of the International Society for Matrix Biology Vol. 68-69 page： 628 - 636 2018.8
Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain
Takeuchi Akihide, Iida Kei, Tsubota Toshiaki, Hosokawa Motoyasu, Denawa Masatsugu, Brown J. B., Ninomiya Kensuke, Ito Mikako, Kimura Hiroshi, Abe Takaya, Kiyonari Hiroshi, Ohno Kinji, Hagiwara Masatoshi
CELL REPORTS Vol. 23 ( 5 ) page： 1326-1341 2018.5
Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles.
Nishiwaki H, Ito M, Negishi S, Sobue S, Ichihara M, Ohno K
Free radical research Vol. 52 ( 4 ) page： 434 - 445 2018
Inhalation of hydrogen gas elevates urinary 8-hydroxy-2'-deoxyguanine in Parkinson's disease.
Hirayama M, Ito M, Minato T, Yoritaka A, LeBaron TW, Ohno K
Medical gas research Vol. 8 ( 4 ) page： 144 - + 2018
Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/beta-catenin signaling
Miyamoto Kentaro, Ohkawara Bisei, Ito Mikako, Masuda Akio, Hirakawa Akihiro, Sakai Tadahiro, Hiraiwa Hideki, Hamada Takashi, Ishiguro Naoki, Ohno Kinji
PLOS ONE Vol. 12 ( 9 ) page： e0184388 2017.9
SRSF1 suppresses selection of intron-distal 5 ' splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein
Bin Ahsan Khalid, Masuda Akio, Rahman Mohammad Alinoor, Takeda Jun-ichi, Nazim Mohammad, Ohkawara Bisei, Ito Mikako, Ohno Kinji
SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 10446 2017.9
Wnt/beta-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells
Kishimoto Yasuzumi, Ohkawara Bisei, Sakai Tadahiro, Ito Mikako, Masuda Akio, Ishiguro Naoki, Shukunami Chisa, Docheva Denitsa, Ohno Kinji
PLOS ONE Vol. 12 ( 7 ) page： e0182051 2017.7
Protein-Anchoring Therapy of Biglycan for Mdx Mouse Model of Duchenne Muscular Dystrophy Reviewed
Ito Mikako, Ehara Yuka, Li Jin, Inada Kosuke, Ohno Kinji
HUMAN GENE THERAPY Vol. 28 ( 5 ) page： 428-436 2017.5
Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms
Nazim Mohammad, Masuda Akio, Rahman Mohammad Alinoor, Nasrin Farhana, Takeda Jun-Ichi, Ohe Kenji, Ohkawara Bisei, Ito Mikako, Ohno Kinji
NUCLEIC ACIDS RESEARCH Vol. 45 ( 3 ) page： 1455-1468 2017.2
Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice
Hasegawa Satoru, Ito Mikako, Fukami Mayu, Hashimoto Miki, Hirayama Masaaki, Ohno Kinji
REDOX REPORT Vol. 22 ( 1 ) page： 26-34 2017
Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders
Ohno Kinji, Ohkawara Bisei, Ito Mikako
EXPERT OPINION ON THERAPEUTIC TARGETS Vol. 21 ( 10 ) page： 949-958 2017
Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling. Reviewed
Kenji Otsuka, Mikako Ito, Bisei Ohkawara, Akio Masuda, Yu Kawakami, Ko Sahashi, Hiroshi Nishida, Naoki Mabuchi, Akemi Takano, Andrew G. Engel, Kinji Ohno
Scientific Reports Vol. 5 ( 13928 ) 2015.9
Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects. Reviewed
Kishimoto Y, Kato T, Ito M, Azuma Y, Fukasawa Y , Ohno K, Kojima S
J Thorac Cardiovasc Surg. Vol. 150 ( 3 ) page： 645-54 2015.9
A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space. Reviewed
Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K.
Neuromuscul Disord. Vol. 25 ( 8 ) page： 667-71 2015.8
Dopaminergic neuron-like stem cells from human deciduous teeth promote neurological recovery in Parkinsonian rats by cell replacement and paracrine neuroregenerative mechanisms Reviewed
Hiromi Fujii, Kohki Matsubara, Kiyoshi Sakai, Mikako Ito, Kinji Ohno, Minoru Ueda, Akihito Yamamoto
Brain Research Vol. 10 ( 1613 ) page： 59-72 2015.7
Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Reviewed
Sobue S, Yamai K, Ito M, Ohno K, Ito M, Iwamoto T, Qiao S, Ohkuwa T, Ichihara M.
Mol Cell Biochem. Vol. 403 ( 1-2 ) page： 231-41 2015.5
Position-specific binding of FUS to nascent RNA regulates mRNA length. Reviewed
Masuda A., Takeda J., Okuno T., Okamoto T., Ohkawara B., Ito M., Ishigaki S., Sobue G., Ohno K.
Genes Dev. Vol. 29 ( 10 ) page： 1045-57 2015.5
Congenital myasthenic syndrome in Japan: ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits. Reviewed
Azuma Y, Nakata T, Tanaka M, Shen XM, Ito M, Iwata S, Okuno T, Nomura Y, Ando N, Ishigaki K, Ohkawara B, Masuda A, Natsume J, Kojima S, Sokabe M, Ohno K.
Neuromuscul Disord. Vol. 25 ( 1 ) page： 60-9 2015.1
Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage by in utero ischemia-reperfusion Reviewed
Mano, Y. and Kotani, T. and Ito, M. and Nagai, T. and Ichinohashi, Y. and Yamada, K. and Ohno, K. and Kikkawa, F. and Toyokuni, S.
Free Radic Biol Med page： in press 2014
Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia Reviewed
Matsushita, M. and Kitoh, H. and Ohkawara, B. and Mishima, K. and Kaneko, H. and Ito, M. and Masuda, A. and Ishiguro, N. and Ohno, K.
PLoS ONE Vol. 8 ( 12 ) page： e81569 2014
LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated musk signaling in a position-specific manner Reviewed
Ohkawara, B. and Cabrera-Serrano, M. and Nakata, T. and Milone, M. and Asai, N. and Ito, K. and Ito, M. and Masuda, A. and Ito, Y. and Engel, A. G. and Ohno, K.
Hum Mol Genet page： in press 2014
Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling Reviewed
Takamatsu, A. and Ohkawara, B. and Ito, M. and Masuda, A. and Sakai, T. and Ishiguro, N. and Ohno, K.
PLOS ONE page： in press 2014
Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells Reviewed
Iio, A. and Ito, M. and Itoh, T. and Terazawa, R. and Fujita, Y. and Nozawa, Y. and Ohsawa, I. and Ohno, K. and Ito, M.
Med Gas Res Vol. 3 ( 1 ) page： 6 2013
Mutations in the C-Terminal Domain of ColQ in Endplate Acetylcholinesterase Deficiency Compromise ColQ-MuSK Interaction Reviewed
Nakata, T. and Ito, M. and Azuma, Y. and Otsuka, K. and Noguchi, Y. and Komaki, H. and Okumura, A. and Shiraishi, K. and Masuda, A. and Natsume, J. and Kojima, S. and Ohno, K.
Hum Mutat Vol. 34 ( 7 ) page： 997-1004 2013
Collagen Q is a key player for developing rational therapy for congenital myasthenia andfor dissecting the mechanisms of anti-MuSK myasthenia gravis Reviewed
Ohno, K. and Ito, M. and Kawakami, Y.
J Mol Neurosci page： 3 pages 2013
Specific binding of collagen Q to the neuromuscular junction is exploited to cure congenital myasthenia and to explore bases of myasthenia gravis Reviewed
Ohno, K. and Ito, M. and Kawakami, Y. and Krejci, E. and Engel, A. G.
Chem Biol Interact Vol. 203 ( 1 ) page： 335-340 2013
HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA Reviewed
Rahman, M. A. and Masuda, A. and Ohe, K. and Ito, M. and Hutchinson, D. O. and Mayeda, A. and Engel, A. G. and Ohno, K.
Sci Rep Vol. 3 page： 2931 2013
Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice Reviewed
Yamamoto, R. and Matsushita, M. and Kitoh, H. and Masuda, A. and Ito, M. and Katagiri, T. and Kawai, T. and Ishiguro, N. and Ohno, K.
J Bone Miner Metab Vol. 31 ( 1 ) page： 26-33 2013
Four parameters increase the sensitivity and specificity of the exon array analysis and disclose 25 novel aberrantly spliced exons in myotonic dystrophy Reviewed
Yamashita, Y. and Matsuura, T. and Shinmi, J. and Amakusa, Y. and Masuda, A. and Ito, M. and Kinoshita, M. and Furuya, H. and Abe, K. and Ibi, T. and Sahashi, K. and Ohno, K.
J Hum Genet Vol. 57 ( 6 ) page： 368-74 2012
Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats Reviewed
Ito, M. and Hirayama, M. and Yamai, K. and Goto, S. and Ito, M. and Ichihara, M. and Ohno, K.
Med Gas Res Vol. 2 ( 1 ) page： 15 2012
Protein-anchoring Strategy for Delivering Acetylcholinesterase to the Neuromuscular Junction Reviewed
Ito, M. and Suzuki, Y. and Okada, T. and Fukudome, T. and Yoshimura, T. and Masuda, A. and Takeda, S. and Krejci, E. and Ohno, K.
Mol Ther Vol. 20 ( 7 ) page： 1384-92 2012
CUGBP1 and MBNL1 preferentially bind to 3' UTRs and facilitate mRNA decay Reviewed
Masuda, A. and Andersen, H. S. and Doktor, T. K. and Okamoto, T. and Ito, M. and Andresen, B. S. and Ohno, K.
Sci Rep Vol. 2 page： 209 2012
Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases Reviewed
Ohno, K. and Ito, M. and Ichihara, M. and Ito, M.
Oxidative Medicine and Cellular Longevity Vol. 2012(2012) page： Article ID 353152, 11 pages 2012
Anti-MuSK autoantibodies block binding of collagen Q to MuSK Reviewed
Kawakami, Y. and Ito, M. and Hirayama, M. and Sahashi, K. and Ohkawara, B. and Masuda, A. and Nishida, H. and Mabuchi, N. and Engel, A. G. and Ohno, K.
Neurology Vol. 77 ( 20 ) page： 1819-26 2011
AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon Reviewed
Fu, Y. and Masuda, A. and Ito, M. and Shinmi, J. and Ohno, K.
Nucleic Acids Research Vol. 39 ( 10 ) page： 4396-404 2011
Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease Reviewed
Hirayama, M. and Nakamura, T. and Watanabe, H. and Uchida, K. and Hama, T. and Hara, T. and Niimi, Y. and Ito, M. and Ohno, K. and Sobue, G.
Parkinsonism Relat Disord Vol. 17 ( 1 ) page： 46-9 2011
Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies Reviewed
Ito, M. and Ibi, T. and Sahashi, K. and Ichihara, M. and Ito, M. and Ohno, K.
Medical Gas Research Vol. 1 page： 24 2011
Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages Reviewed
Itoh, T. and Hamada, N. and Terazawa, R. and Ito, M. and Ohno, K. and Ichihara, M. and Nozawa, Y. and Ito, M.
Biochem Biophys Res Commun Vol. 411 ( 1 ) page： 143-9 2011
Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8 Reviewed
Kaneko, H. and Kitoh, H. and Matsuura, T. and Masuda, A. and Ito, M. and Mottes, M. and Rauch, F. and Ishiguro, N. and Ohno, K.
Hum Genet Vol. 130 ( 5 ) page： 671-83 2011
Molecular hydrogen suppresses Fc epsilon RI-mediated signal transduction and prevents degranulation of mast cells Reviewed
Itoh, T. and Fujita, Y. and Ito, M. and Masuda, A. and Ohno, K. and Ichihara, M. and Kojima, T. and Nozawa, Y. and Ito, M.
Biochemical and Biophysical Research Communications Vol. 389 ( 4 ) page： 651-656 2009
Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndrome Reviewed
Bian, Y. and Masuda, A. and Matsuura, T. and Ito, M. and Okushin, K. and Engel, A. G. and Ohno, K.
Hum Mol Genet Vol. 18 ( 7 ) page： 1229-1237 2009
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease Reviewed
Fu, Y. and Ito, M. and Fujita, Y. and Ito, M. and Ichihara, M. and Masuda, A. and Suzuki, Y. and Maesawa, S. and Kajita, Y. and Hirayama, M. and Ohsawa, I. and Ohta, S. and Ohno, K.
Neuroscience Letters Vol. 453 page： 81–85 2009
hnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndrome Reviewed
Masuda, A. and Shen, X. M. and Ito, M. and Matsuura, T. and Engel, A. G. and Ohno, K.
Hum Mol Genet Vol. 17 ( 24 ) page： 4022-4035 2008
Viral vector-medicated expression of human collagen Q in cultured cells Reviewed
Ito, M. and Masuda, A. and Jinno, S. and Katagiri, T. and Krejci, E. and Ohno, K.
Chem Biol Interact Vol. 175 ( 1-3 ) page： 346-348 2008
An upper limit of the ratio of DNA volume to nuclear volume exists in plants Reviewed
Fujimoto, S. and Ito, M. and Matsunaga, S. and Fukui, K.
Genes Genet Syst Vol. 80 ( 5 ) page： 345-350 2005
Identification and characterization of methylated DNA binding protein in Arabidopsis Reviewed
Ito, M. and Koike, A. and Yamaguchi, Y. and Koizumi, N. and Sano, H.
Plant Physiology Vol. 133 page： 1747-1754 2003
Methylated DNA-binding proteins from Arabidopsis Reviewed
Ito, M. and Koike, A. and Koizumi, N. and Sano, H.
Plant Physiol Vol. 133 ( 4 ) page： 1747-1754 2003
Periodic DNA methylation in maize nucleosomes and demethylation by environmental stress Reviewed
Steward, N. and Ito, M. and Yamaguchi, Y. and Koizumi, N. and Sano, H.
J Biol Chem Vol. 277 ( 40 ) page： 37741-37746 2002
A chloroplast-resident DNA methyltransferase is responsible for hypermethylation of chloroplast genes in Chlamydomonas maternal gametes Reviewed
Nishiyama, R. and Ito, M. and Yamaguchi, Y. and Koizumi, N. and Sano, H.
Proc Natl Acad Sci U S A Vol. 99 ( 9 ) page： 5925-5930 2002
Transition between two forms of heterochromatin at plant subtelomeres Reviewed
Sykorova, E. and Fajkus, J. and Ito, M. and Fukui, K.
Chromosome Res Vol. 9 ( 4 ) page： 309-323 2001
Genome and Chromosome Dimensions of Lotus japonicus Reviewed
Ito, M. and Miyamoto, J. and Mori, Y. and Fujimoto, S. and Uchiumi, T. and Abe, M. and Suzuki, A. and Tabata, S. and Fukui, K.
J Plant Res Vol. 113 page： 435-442 2001
Characterization of Spinach (Spinacia oleracea L.) Chromosomes by Condensation Patterns and Physical Mapping of 5S and 45S rDNA by FISH Reviewed
Ito, M. and Ohmido, N. and Akiyama, Y. and Fukui, K. and Koba, T.
J. Ame. Soci. Hort. Sci. Vol. 125 page： 59-62 2000
Quantitative chromosome map of Arabidopsis thaliana L. by imaging methods Reviewed
Ito, M. and Ohmido, N. and Akiyama, Y. and Fukui, K.
Cytologia Vol. 65 page： 325-331 2000
生物の科学遺伝 63ー5 タンパク質係留治療
大野欽司,伊藤美佳子（ Role： Sole author）
エヌ・ティー・エス 2009.9 （ ISBN:4860432819 ）
「クロモソーム植物染色体研究の方法」福井希一、向井康比己、谷口研至編著 アラビドプシスにおける染色体観察方法
伊藤美佳子（ Role： Joint author）
養賢堂 2006
植物細胞工学シリーズ13「植物細胞の分裂」町田康則、福田泰穂監修 シロイヌナズナ染色体の識別・同定
伊藤美佳子 福井希一（ Role： Joint author）
秀潤社 2000
Protein-anchoring therapy for delivering acetylcholinesterase to the neuromuscular junction International conference
Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K
11th International Meeting on Cholinesterases (Poster), Kazan, Russia
Protein-anchoring therapy For delivering acetylcholinesterase to the neuromuscular junction International conference
Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K
17th Annual Meeting of the Japan Society of Gene Therapy (Poster), Fukuoka, Japan
分子状水素はパーキンソン病モデルラットの発症を抑制し、ヒト筋疾患の各種マーカーを改善する
伊藤 美佳子、付 源、衣斐 達、大野 欽司
日本分子生物学会 神戸 ワークショップ
rAAV8-Mediated Protein-Anchoring Therapy for Targeting Collagen Q-Tailed Acetylcholinesterase to the Neuromuscular Junction International conference
Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K
American Society of Gene & Cell Therapy 13th Annual Meeting (Platform), Washington DC, USA
rAAV8-mediated protein anchoring of asymmetric acetylcholinesterase (AChE) to the synaptic basal lamina at the neuromuscular junction (NMJ) International conference
Ito M, Suzuki Y, Okada T, Fukudome T, Masuda A, Yoshimura T, Takeda S, Krejci E, Ohno K
48th Annual Meeting of the American Society for Cell Biology (Poster), San Francisco, San Diego, California, USA
Adeno-associated virus serotype 8-mediated targeting of asymmetric acetylcholinesterase to the synaptic basal lamina at the neuromuscular junction International conference
Ito M, Suzuki Y, Okada T, Fukudome T, Masuda A, Yoshimura T, Takeda S, Krejci E, Ohno K
38th Annual Meeting, Society for Neuroscience (Poster), Washington DC, USA
Gene Therapy for Collagen Q defects in congenital myasthenic syndromes International conference
Ito M, Masuda A, Jinno S, Katagiri T, Krejci E, Ohno K
The IXth International Meeting on Cholinesterases, Shuzou, China
先天性筋無力症候群における分子病態の解明と新規治療法の開発
2019.4 - 2020.3
学内共同研究
iPS 細胞を用いた先天性筋無力症候群の病態解析および新規治療法の開発
2019.4 - 2020.3
学内共同研究
腸内細菌叢の変動によるパーキンソン病発症機序の解明と発症抑制・病態進行抑制法の開発
2018.4 - 2019.3
学内共同研究
パーキンソン病患者の腸内細菌層(マイクロバイオーム)解析による病態解明
2016.4 - 2017.4
学内共同研究
パーキンソン病の発症と病態進行に関わる腸内細菌叢の解明
2015.10 - 2016.9
学内共同研究
筋ジストロフィーにおける細胞外分子biglycan補充療法の開発
2012 - 2013
学内共同研究
分子状水素による血液製剤保存法の開発及び輸血関連性肺障害の予防効果の検討
2010.8 - 2011.3
Aberrant splicing in neuromuscular diseases
2009.9 - 2013.3
Pathological analysis of limb girdle congenital myasthenia and development of new therapy
Grant number：20K06925 2020.4 - 2023.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Principal investigator
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
Pathological analysis of GFPT1 congenital myasthenia and development of new therapy using iPS cells.
Grant number：17K07094 2017.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Ito Mikako
Authorship：Principal investigator
Grant amount：\5070000 （ Direct Cost: \3900000 、 Indirect Cost：\1170000 ）
One of the causative molecules of congenital myasthesis syndrome (CMS) is a mutation in GFPT1, a glycosylation enzyme of proteins and lipids, which is characterized by limb-type muscle weakness. GFPT1-L isoform is formed in skeletal muscle and enzyme activity is reduced. In this study, in order to clarify the role of GFPT1-L in skeletal muscle, model mouse Gfpt1-L-/-was prepared and phenotypic analysis was performed.
In addition, we identified the GFPT1 c.722 ^ 723insG mutation in CMS patients and prepared a model mouse of the mutation. The mice were decreased motor function, decreased amount of glycosylated protein, fragmentation of AChR cluster, muscle atrophy, and increased interstitial space. of muscle fiber. It showed a patient-like phenotype.
iPS細胞を用いたGFPT1先天性筋無力症の病態解析および治療研究
2017.4 - 2020.3
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
筋ジストロフィーにおける細胞外分子補充療法の開発
2013.4 - 2017.3
科学研究費補助金 基盤研究(C)
伊藤美佳子
Authorship：Principal investigator
神経筋接合部の正常構築と分子病態研究（大野欽司）
2012.4 - 2015.3
科学研究費補助金 基盤研究(B)
大野欽司
Authorship：Coinvestigator(s)
重症筋無力症における抗ＭｕＳＫ抗体の認識分子同定
2011.4 - 2013.3
科学研究費補助金 若手研究(B)
伊藤美佳子
Authorship：Principal investigator
骨格筋細胞外分子欠損症における、組織標的シグナルを利用した汎用治療法の開発研究
2009.4 - 2011.3
科学研究費補助金 若手研究(B)
伊藤美佳子
Authorship：Principal investigator
神経筋接合部信号伝達障害に対するタンパク標的治療法の開発研究
2007.4 - 2009.3
科学研究費補助金 若手研究(B)
伊藤 美佳子
Authorship：Principal investigator
基盤医科学実習
2022
生物学基礎１
2022
生物学基礎II
2021
生物学基礎II
2020
自然環境と人間
2015
自然環境と人間
2011
