2024/09/19 更新

写真a

ナカヤマ ゴロウ
中山 吾郎
NAKAYAMA Goro
所属
大学院医学系研究科 総合医学専攻 病態外科学 准教授
大学院担当
大学院医学系研究科
学部担当
医学部 医学科
職名
准教授

学位 1

  1. 医学博士 ( 2007年11月   名古屋大学 ) 

研究キーワード 2

  1. 大腸癌に対する外科的治療

  2. 炎症性腸疾患に対する外科治療

研究分野 1

  1. その他 / その他  / 消化器外科学

所属学協会 4

  1. 日本内視鏡外科学会   技術認定医

  2. 制癌剤適応研究会   幹事

  3. 大腸癌研究会   施設代表者,世話人

  4. 日本ロボット外科学会   認定医

委員歴 1

  1. 名古屋大学医学部附属病院IRB   専門分野委員(外科系)  

    2015年4月 - 現在   

 

論文 145

  1. Catheter-related bloodstream infection caused by Lacticaseibacillus paracasei: A case report and literature review

    Fukuda, Y; Morioka, H; Yamamoto, S; Iguchi, M; Umeda, S; Asahara, T; Kanda, K; Oka, K; Nakayama, G; Yagi, T

    JOURNAL OF INFECTION AND CHEMOTHERAPY   30 巻 ( 7 ) 頁: 664 - 667   2024年7月

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  2. Prognostic Impact of CDKN2A Mutations Associated With Smoking and Drinking History in Japanese Digestive Cancers.

    Fujita K, Hayashi M, Nakagawa N, Kurimoto K, Inokawa Y, Takami H, Nakanishi K, Umeda S, Shimizu D, Hattori N, Kanda M, Tanaka C, Nakayama G, Kodera Y

    Anticancer research   44 巻 ( 6 ) 頁: 2699 - 2707   2024年6月

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    記述言語:英語  

    DOI: 10.21873/anticanres.17077

    PubMed

  3. Outcomes of surgical treatment for enterovesical fistula in Crohn's disease.

    Hattori N, Nakayama G, Umeda S, Nakamura M, Yamamura T, Sawada T, Nakanishi K, Shimizu D, Kanda M, Hayashi M, Tanaka C, Kodera Y

    Nagoya journal of medical science   86 巻 ( 2 ) 頁: 280 - 291   2024年5月

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    記述言語:英語  

    DOI: 10.18999/nagjms.86.2.280

    PubMed

  4. Killer cell lectin-like receptor G2 facilitates aggressive phenotypes of gastric cancer cells via dual activation of the ERK1/2 and JAK/STAT pathways

    Ito, Y; Kanda, M; Sasahara, M; Tanaka, C; Shimizu, D; Umeda, S; Inokawa, Y; Hattori, N; Hayashi, M; Nakayama, G; Kodera, Y

    GASTRIC CANCER   27 巻 ( 3 ) 頁: 506 - 518   2024年5月

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  5. Therapeutic antibody targeting natriuretic peptide receptor 1 inhibits gastric cancer growth <i>via</i> BCL-2-mediated intrinsic apoptosis

    Sasahara, M; Kanda, M; Tanaka, C; Shimizu, D; Umeda, S; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Nakayama, G; Kodera, Y

    INTERNATIONAL JOURNAL OF CANCER   154 巻 ( 7 ) 頁: 1272 - 1284   2024年4月

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    記述言語:英語  

    DOI: 10.1002/ijc.34831

    Web of Science

    PubMed

  6. Risk Factors for Long-term Body Weight Loss After Proximal Gastrectomy: A Retrospective Analysis

    Agatsuma, Y; Nakanishi, K; Tanaka, C; Kanda, M; Shimizu, D; Umeda, S; Kurimoto, K; Inokawa, Y; Takami, H; Hattori, N; Hayashi, M; Nakayama, G; Fujiwara, M; Kodera, Y

    ANTICANCER RESEARCH   44 巻 ( 4 ) 頁: 1645 - 1651   2024年4月

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  7. ASO Visual Abstract: Absence of Hypercoagulation Status After Neoadjuvant Treatment is Associated with Favorable Prognosis in Patients Undergoing Subtotal Esophagectomy for Esophageal Squamous Cell Carcinoma

    Sugiyama, F; Kanda, M; Shimizu, D; Umeda, S; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Nakayama, G; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY     2024年2月

  8. Absence of Hypercoagulation Status after Neoadjuvant Treatment is Associated with Favorable Prognosis in Patients Undergoing Subtotal Esophagectomy for Esophageal Squamous Cell Carcinoma

    Sugiyama, F; Kanda, M; Shimizu, D; Umeda, S; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Nakayama, G; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   31 巻 ( 5 ) 頁: 3417 - 3425   2024年1月

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  9. Increased STX3 transcript and protein levels were associated with poor prognosis in two independent cohorts of esophageal squamous cell carcinoma patients

    Shinozuka, T; Kanda, M; Sato, Y; Shimizu, D; Tanaka, C; Umeda, S; Inokawa, Y; Hattori, N; Hayashi, M; Nakayama, G; Kodera, Y

    CANCER MEDICINE   12 巻 ( 24 ) 頁: 22185 - 22195   2023年12月

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    記述言語:英語  

    DOI: 10.1002/cam4.6770

    Web of Science

    PubMed

  10. Predictive impacts of peritoneal washing cytology for surgical resection-intended pancreatic cancer cases: Establishment of planned staging laparoscopy criteria

    Tanaka, N; Takami, H; Hayashi, M; Inokawa, Y; Kurimoto, K; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Kodera, Y

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   30 巻 ( 11 ) 頁: 1273 - 1281   2023年11月

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    記述言語:英語  

    DOI: 10.1002/jhbp.1373

    Web of Science

    PubMed

  11. Risk Stratification by Tissue<i> GAD1</i> Expression Level in Curatively Resected Esophageal Squamous Cell Carcinoma

    Kishida, T; Kanda, M; Sato, Y; Shimizu, D; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Nakayama, G; Kodera, Y

    CANCER GENOMICS & PROTEOMICS   20 巻 ( 6 ) 頁: 617 - 625   2023年11月

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    記述言語:英語  

    DOI: 10.21873/cgp.20410

    Web of Science

    PubMed

  12. Identification of stromal cell-derived factor 4 as a liquid biopsy-based diagnostic marker in solid cancers

    Shinozuka, T; Kanda, M; Shimizu, D; Umeda, S; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Nakayama, G; Kodera, Y

    SCIENTIFIC REPORTS   13 巻 ( 1 ) 頁: 15540   2023年9月

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  13. A proposed new Japanese classification of synchronous peritoneal metastases from colorectal cancer: A multi-institutional, prospective, observational study conducted by the Japanese Society for Cancer of the Colon and Rectum

    Kobayashi, H; Kotake, K; Kawasaki, M; Kanemitsu, Y; Kinugasa, Y; Ueno, H; Maeda, K; Suto, T; Itabashi, M; Funahashi, K; Ozawa, H; Koyama, F; Noura, S; Ishida, H; Ohue, M; Kiyomatsu, T; Ishihara, S; Koda, K; Baba, H; Kawada, K; Hashiguchi, Y; Goi, T; Toiyama, Y; Tomita, N; Sunami, E; Akagi, Y; Watanabe, J; Hakamada, K; Nakayama, G; Sugihara, K; Ajioka, Y

    ANNALS OF GASTROENTEROLOGICAL SURGERY   7 巻 ( 5 ) 頁: 765 - 771   2023年9月

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    記述言語:英語  

    DOI: 10.1002/ags3.12679

    Web of Science

    PubMed

  14. The preoperative systemic immune-inflammation index is associated with an unfavorable prognosis for patients undergoing curative resection of esophageal squamous cell carcinoma after neoadjuvant therapy

    Obata, Y; Kanda, M; Shimizu, D; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Nakayama, G; Kodera, Y

    SURGERY TODAY   53 巻 ( 8 ) 頁: 964 - 972   2023年8月

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  15. High Preoperative Platelet to Lymphocyte Ratio is Associated with a Greater Risk of Postoperative Complications and Hematogenous Recurrences in Esophageal Squamous Cell Carcinoma Patients Receiving Neoadjuvant Treatment

    Sasahara, M; Kanda, M; Shimizu, D; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Fujiwara, M; Nakayama, G; Kodera, Y

    DIGESTIVE SURGERY   40 巻 ( 1-2 ) 頁: 48 - 57   2023年7月

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    記述言語:英語  

    DOI: 10.1159/000530018

    Web of Science

    PubMed

  16. High Preoperative Serum D-dimer Predicts Unfavorable Survival Outcomes for Pancreatic Cancer Patients

    Otsu, T; Hayashi, M; Takami, H; Inokawa, Y; Tanaka, N; Kurimoto, K; Nakanishi, K; Umeda, S; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Kodera, Y

    ANTICANCER RESEARCH   43 巻 ( 7 ) 頁: 3173 - 3181   2023年7月

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  17. Optimal molecular-targeted therapies as first-line treatment for <i>RAS</i> wild-type, right-sided metastatic colorectal cancer from the Analysis and Research in Cancers of the Digestive System (ARCAD) database

    Yamazaki, K; Takeda, Y; Misumi, T; Suzuki, M; Wakabayashi, M; Bando, H; Oki, E; Douillard, JY; Punt, CJA; Van Cutsem, E; Bokemeyer, C; Venook, AP; Maehara, Y; Heinemann, V; Cremolini, C; Nakayama, G; Andre, T; Shi, Q; De Gramont, A; Yoshino, T

    JOURNAL OF CLINICAL ONCOLOGY   41 巻 ( 16 )   2023年6月

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  18. Albumin-Globulin Ratio Indicates the Survival Outcome of Pancreatic Cancer Cases Who Underwent Preoperative Treatment and Curative Surgical Resection

    Hayashi, M; Kobayashi, D; Takami, H; Inokawa, Y; Tanaka, N; Kurimoto, K; Nakanishi, K; Umeda, S; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Kodera, Y

    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL   75 巻 ( 5 ) 頁: 1330 - 1339   2023年5月

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  19. Molecular genetic positioning of small intestine and papilla of Vater carcinomas including clinicopathological classification

    Nakamura, M; Okamura, Y; Ohshima, K; Sugiura, T; Ashida, R; Ohgi, K; Bando, E; Fujiya, K; Shiomi, A; Kagawa, H; Imamura, T; Nakayama, G; Kodera, Y; Uesaka, K; Ohike, N; Norose, T; Sasaki, K; Sugino, T; Ohnami, S; Nagashima, T; Urakami, K; Akiyama, Y; Yamaguchi, K

    CANCER MEDICINE   12 巻 ( 10 ) 頁: 11491 - 11502   2023年5月

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    記述言語:英語  

    DOI: 10.1002/cam4.5877

    Web of Science

    PubMed

  20. Impact of obstructive ventilatory impairment on intraoperative bleeding during laparoscopic hepatectomy

    Nakamura, M; Okamura, Y; Sugiura, T; Ashida, R; Ohgi, K; Yamada, M; Otsuka, S; Nakayama, G; Kodera, Y; Uesaka, K

    LANGENBECKS ARCHIVES OF SURGERY   408 巻 ( 1 ) 頁: 122   2023年3月

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  21. Perioperative changes in geriatric functions of elderly patients undergoing surgical resection for gastric cancer.

    Tanaka, C; Kanda, M; Nakanishi, K; Umeda, S; Shimizu, D; Inokawa, Y; Takami, H; Hayashi, M; Nakayama, G; Fujiwara, M; Kodera, Y; Hattori, N

    JOURNAL OF CLINICAL ONCOLOGY   41 巻   頁: 811 - 811   2023年2月

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  22. Proposal of a coagulation score to predict postoperative survival of patients undergoing neoadjuvant therapy followed by subtotal esophagectomy for squamous cell carcinoma of the esophagus.

    Sugiyama, F; Shimizu, D; Kanda, M; Tanaka, C; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Nakayama, G; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   41 巻   頁: 448 - 448   2023年2月

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  23. Controlling Nutritional Status Score Serves as a Prognosticator in Esophageal Squamous Cell Carcinoma: Optimal Timing of Evaluation of Patients Undergoing Neoadjuvant Treatment

    Nonogaki, I; Kanda, M; Shimizu, D; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Koike, M; Nakayama, G; Kodera, Y

    WORLD JOURNAL OF SURGERY   47 巻 ( 1 ) 頁: 217 - 226   2023年1月

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  24. The effects of ustekinumab on small intestinal lesions and stenotic lesions

    Wada, H; Murate, K; Nakamura, M; Furukawa, K; Kakushima, N; Yamamura, T; Maeda, K; Sawada, T; Ishikawa, E; Ishikawa, T; Ohno, E; Honda, T; Kawashima, H; Nakayama, G; Hattori, N; Umeda, S; Ishigami, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 4 ) 頁: 825 - 838   2022年11月

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  25. ASO Visual Abstract: Downregulation of ROBO4 in Pancreatic Cancer Serves as a Biomarker of Poor Prognosis and Indicates Increased Cell Motility and Proliferation Through Activation of MMP-9

    Yamanaka, M; Hayashi, M; Sonohara, F; Yamada, S; Tanaka, H; Sakai, A; Mii, S; Kobayashi, D; Kurimoto, K; Tanaka, N; Inokawa, Y; Takami, H; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   29 巻 ( 11 ) 頁: 7192 - 7193   2022年10月

  26. Downregulation of ROBO4 in Pancreatic Cancer Serves as a Biomarker of Poor Prognosis and Indicates Increased Cell Motility and Proliferation Through Activation of MMP-9

    Yamanaka, M; Hayashi, M; Sonohara, F; Yamada, S; Tanaka, H; Sakai, A; Mii, S; Kobayashi, D; Kurimoto, K; Tanaka, N; Inokawa, Y; Takami, H; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   29 巻 ( 11 ) 頁: 7180 - 7189   2022年10月

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  27. Transcriptomic profiling on localized gastric cancer identified <i>CPLX1</i> as a gene promoting malignant phenotype of gastric cancer and a predictor of recurrence after surgery and subsequent chemotherapy

    Tanaka, H; Kanda, M; Shimizu, D; Tanaka, C; Inokawa, Y; Hattori, N; Hayashi, M; Nakayama, G; Kodera, Y

    JOURNAL OF GASTROENTEROLOGY   57 巻 ( 9 ) 頁: 640 - 653   2022年9月

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  28. Comparison Between FOLFIRINOX and nal-IRI/FL as Second-line Treatment After Gemcitabine Plus Nab-paclitaxel for Pancreatic Cancer br

    Otsu, T; Inokawa, Y; Takami, H; Hayashi, M; Kurimoto, K; Tanaka, N; Tanaka, H; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Kodera, Y

    ANTICANCER RESEARCH   42 巻 ( 8 ) 頁: 3889 - 3894   2022年8月

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  29. Expression of cellular retinoic acid binding protein 1 predicts peritoneal recurrence of gastric cancer

    Sakata, K; Kanda, M; Shimizu, D; Nakamura, S; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Nakayama, G; Kodera, Y

    INTERNATIONAL JOURNAL OF ONCOLOGY   60 巻 ( 6 )   2022年6月

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  30. Lysosomal-associated membrane protein family member 5 promotes the metastatic potential of gastric cancer cells

    Umeda, S; Kanda, M; Shimizu, D; Nakamura, S; Sawaki, K; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Nakayama, G; Kodera, Y

    GASTRIC CANCER   25 巻 ( 3 ) 頁: 558 - 572   2022年5月

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  31. Direct Observation of Retinal Microvessels in Cancer Patients After Systemic Administration of Bevacizumab and Oxaliplatin.

    Mitsuma A, Ito Y, Shimokata T, Tanaka C, Uehara K, Nakayama G, Terasaki H, Ando Y

    Cancer diagnosis & prognosis   2 巻 ( 3 ) 頁: 330 - 335   2022年5月

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    記述言語:英語  

    DOI: 10.21873/cdp.10113

    PubMed

  32. Drain Amylase Concentrations at 3 h After Gastrectomy Enhance Early Prediction of Postoperative Peripancreatic Inflammatory Fluid Collection

    Nakanishi, K; Kanda, M; Tanaka, C; Takeda, S; Tanaka, K; Shimizu, D; Inokawa, Y; Hattori, N; Hayashi, M; Nakayama, G; Fujiwara, M; Kodera, Y

    WORLD JOURNAL OF SURGERY   46 巻 ( 3 ) 頁: 648 - 655   2022年3月

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  33. Neoadjuvant docetaxel, oxaliplatin plus S-1 for treating clinical stage III squamous cell carcinoma of the esophagus: Study protocol of an open-label phase II trial

    Kanda, M; Shimizu, D; Miyata, K; Maeda, O; Tanaka, C; Inokawa, Y; Hattori, N; Hayashi, M; Ando, M; Kuwatsuka, Y; Murotani, K; Nakayama, G; Koike, M; Ando, Y; Ebata, T; Kodera, Y

    CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS   24 巻   頁: 100853   2021年12月

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  34. The significance of the time to arterial perfusion in intraoperative ICG angiography during colorectal surgery

    Aiba, T; Uehara, K; Ogura, A; Tanaka, A; Yonekawa, Y; Hattori, N; Nakayama, G; Kodera, Y; Ebata, T; Nagino, M

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   35 巻 ( 12 ) 頁: 7227 - 7235   2021年12月

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  35. Impact of molecular surgical margin analysis on the prediction of pancreatic cancer recurrences after pancreaticoduodenectomy

    Sunagawa, Y; Hayashi, M; Yamada, S; Tanabe, H; Kurimoto, K; Tanaka, N; Sonohara, F; Inokawa, Y; Takami, H; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    CLINICAL EPIGENETICS   13 巻 ( 1 ) 頁: 172   2021年12月

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  36. Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells

    Kanda, M; Shimizu, D; Nakamura, S; Sawaki, K; Umeda, S; Miwa, T; Tanaka, H; Inokawa, Y; Hattori, N; Hayashi, M; Tanaka, C; Nakayama, G; Iguchi, Y; Katsuno, M; Kodera, Y

    ONCOGENE   40 巻 ( 36 ) 頁: 5495 - 5504   2021年9月

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  37. A Possible Definition of Oligometastasis in Pancreatic Cancer and Associated Survival Outcomes

    Yamanaka, M; Hayashi, M; Yamada, S; Sonohara, F; Takami, H; Inokawa, Y; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ANTICANCER RESEARCH   41 巻 ( 8 ) 頁: 3933 - 3940   2021年8月

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  38. G-protein subunit gamma-4 expression has potential for detection, prediction and therapeutic targeting in liver metastasis of gastric cancer

    Tanaka, H; Kanda, M; Miwa, T; Umeda, S; Sawaki, K; Tanaka, C; Kobayashi, D; Hayashi, M; Yamada, S; Nakayama, G; Koike, M; Kodera, Y

    BRITISH JOURNAL OF CANCER   125 巻 ( 2 ) 頁: 220 - 228   2021年7月

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  39. High Serum Uric Acid Levels Could Be a Risk Factor of Hepatocellular Carcinoma Recurrences

    Hayashi, M; Yamada, S; Tanabe, H; Takami, H; Inokawa, Y; Sonohara, F; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL   73 巻 ( 6 ) 頁: 996 - 1003   2021年7月

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  40. Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma

    Nakagawa, N; Sonohara, F; Tanaka, K; Sunagawa, Y; Inokawa, Y; Takami, H; Hayashi, M; Yamada, S; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ONCOLOGY LETTERS   22 巻 ( 1 ) 頁: 538   2021年7月

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  41. The carcinoembryonic antigen ratio is a potential predictor of survival in recurrent colorectal cancer

    Suzuki, Y; Ogura, A; Uehara, K; Aiba, T; Ohara, N; Murata, Y; Jinno, T; Mishina, T; Sato, Y; Hattori, N; Nakayama, G; Kodera, Y; Ebata, T

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   26 巻 ( 7 ) 頁: 1264 - 1271   2021年7月

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  42. <i>miR</i>-<i>23b</i>-<i>3p</i> Plays an Oncogenic Role in Hepatocellular Carcinoma

    Hayashi, M; Yamada, S; Kurimoto, K; Tanabe, H; Hirabayashi, S; Sonohara, F; Inokawa, Y; Takami, H; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   28 巻 ( 6 ) 頁: 3416 - 3426   2021年6月

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  43. Indications for neoadjuvant treatment based on risk factors for poor prognosis before and after neoadjuvant chemotherapy alone in patients with locally advanced rectal cancer

    Ogura, A; Uehara, K; Aiba, T; Sando, M; Tanaka, A; Ohara, N; Murata, Y; Sato, Y; Hattori, N; Nakayama, G; Ebata, T; Kodera, Y; Nagino, M

    EJSO   47 巻 ( 5 ) 頁: 1005 - 1011   2021年5月

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  44. Different Characteristics of Serum Alfa Fetoprotein and Serum Des-gamma-carboxy Prothrombin in Resected Hepatocellular Carcinoma

    Hayashi, M; Yamada, S; Takano, N; Okamura, Y; Takami, H; Inokawa, Y; Sonohara, F; Tanaka, N; Shimizu, D; Hattori, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    IN VIVO   35 巻 ( 3 ) 頁: 1749 - 1760   2021年5月

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  45. Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic apoptosis pathway

    Miwa, T; Kanda, M; Shimizu, D; Umeda, S; Sawaki, K; Tanaka, H; Tanaka, C; Hattori, N; Hayashi, M; Yamada, S; Nakayama, G; Koike, M; Kodera, Y

    BRITISH JOURNAL OF CANCER   124 巻 ( 8 ) 頁: 1449 - 1460   2021年4月

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  46. Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma

    Suenaga, M; Fujii, T; Yamada, S; Hayashi, M; Shinjo, K; Takami, H; Niwa, Y; Sonohara, F; Shimizu, D; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kondo, Y; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   28 巻 ( 4 ) 頁: 2277 - 2286   2021年4月

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  47. Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue

    Sunagawa, Y; Yamada, S; Sonohara, F; Kurimoto, K; Tanaka, N; Suzuki, Y; Inokawa, Y; Takami, H; Hayashi, M; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    SCIENTIFIC REPORTS   11 巻 ( 1 ) 頁: 6016   2021年3月

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  48. Tissue <i>RNFT2</i> Expression Levels Are Associated With Peritoneal Recurrence and Poor Prognosis in Gastric Cancer

    Sasahara, M; Kanda, M; Shimizu, D; Tanaka, C; Inokawa, Y; Hattori, N; Hayashi, M; Nakayama, G; Kodera, Y

    ANTICANCER RESEARCH   41 巻 ( 2 ) 頁: 609 - 617   2021年2月

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  49. Randomised phase II trial of capecitabine plus oxaliplatin with continuous versus intermittent use of oxaliplatin as adjuvant chemotherapy for stage II/III colon cancer (CCOG-1302 study)

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    EUROPEAN JOURNAL OF CANCER   144 巻   頁: 61 - 71   2021年2月

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  50. Function and prognostic value of melanoma-associated antigen-D4 protein in esophageal squamous cell carcinoma

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  52. Randomized phase II study comparing the efficacy and safety of SOX versus mFOLFOX6 as neoadjuvant chemotherapy without radiotherapy for locally advanced rectal cancer (KSCC1301)

    Miwa, K; Oki, E; Enomoto, M; Ihara, K; Ando, K; Fujita, F; Tominaga, M; Mori, S; Nakayama, G; Shimokawa, M; Saeki, H; Baba, H; Mori, M; Akagi, Y

    BMC CANCER   21 巻 ( 1 ) 頁: 23   2021年1月

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  53. Perioperative assessment of indocyanine green elimination rate accurately predicts postoperative liver failure in patients undergoing hepatectomy

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    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   28 巻 ( 1 ) 頁: 86 - 94   2021年1月

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    DOI: 10.1002/jhbp.833

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  54. Pancreatic Fat and Body Composition Measurements by Computed Tomography are Associated with Pancreatic Fistula After Pancreatectomy

    Tanaka, K; Yamada, S; Sonohara, F; Takami, H; Hayashi, M; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   28 巻 ( 1 ) 頁: 530 - 538   2021年1月

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  55. Age-Related Differences in the Prognosis of Pancreatic Cancer According to Perioperative Systemic Therapy

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    PANCREAS   50 巻 ( 1 ) 頁: 37 - 46   2021年1月

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  56. Novel Prognostic Implications of Methylated RNA and Demethylases in Resected HCC and Background Liver Tissue

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    ANTICANCER RESEARCH   40 巻 ( 12 ) 頁: 6665 - 6676   2020年12月

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  57. AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer

    Nakamura, S; Kanda, M; Shimizu, D; Tanaka, C; Inokawa, Y; Hattori, N; Hayashi, M; Yamada, S; Nakayama, G; Omae, K; Koike, M; Kodera, Y

    ANTICANCER RESEARCH   40 巻 ( 12 ) 頁: 6713 - 6721   2020年12月

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  58. What is the impact of systemic chemotherapy for lateral lymph nodes in patients with locally advanced low rectal cancer?

    Ogura, A; Uehara, K; Aiba, T; Hattori, N; Nakayama, G; Maeda, O; Ando, Y; Kodera, Y; Ebata, T; Nagino, M

    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE   35 巻 ( 11 ) 頁: 2073 - 2080   2020年11月

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  59. Correlation Between the Metabolic Conversion of a Capecitabine Metabolite, 5′-Deoxy-5-fluorocytidine, and Creatinine Clearance

    Inaishi, T; Fujita, KI; Matsumoto, N; Shimokata, T; Maeda, O; Kikumori, T; Hattori, N; Nakayama, G; Ando, Y

    IN VIVO   34 巻 ( 6 ) 頁: 3539 - 3544   2020年11月

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  60. AnOpen-Label Single-ArmPhaseIIStudy of Treatment with Neoadjuvant S-1 Plus Cisplatin for Clinical StageIIISquamous Cell Carcinoma of the Esophagus

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    ONCOLOGIST   25 巻 ( 11 ) 頁: E1650 - E1654   2020年11月

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  61. Characteristics Associated with Nodal and Distant Recurrence after Curative Resection of Squamous Cell Carcinoma of the Thoracic Esophagus

    Kanda, M; Koike, M; Shimizu, D; Tanaka, C; Hayashi, M; Hattori, N; Yamada, S; Nakayama, G; Fujiwara, M; Kodera, Y

    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS   231 巻 ( 4 ) 頁: E121 - E121   2020年10月

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  62. An outcome analysis of predictive factors for portal or splenic vein thrombosis after distal pancreatectomy

    Tanaka, N; Yamada, S; Sonohara, F; Takami, H; Hayashi, M; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    SURGERY TODAY   50 巻 ( 10 ) 頁: 1282 - 1289   2020年10月

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  63. STRA6 Expression Serves as a Prognostic Biomarker of Gastric Cancer

    Nakamura, S; Kanda, M; Shimizu, D; Sawaki, K; Tanaka, C; Hattori, N; Hayashi, M; Yamada, S; Nakayama, G; Omae, K; Koike, M; Kodera, Y

    CANCER GENOMICS & PROTEOMICS   17 巻 ( 5 ) 頁: 509 - 516   2020年9月

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    記述言語:英語  

    DOI: 10.21873/cgp.20207

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  64. The impact of cancer stem cell markers in the tissues of pancreatic ductal adenocarcinoma for prognosis after surgical resections

    Inokawa, Y; Yamada, S; Hayashi, M; Sunagawa, Y; Sonohara, F; Takami, H; Hattori, N; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Koike, M; Kodera, Y

    CANCER RESEARCH   80 巻 ( 16 )   2020年8月

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    記述言語:日本語  

    DOI: 10.1158/1538-7445.AM2020-6016

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  65. Importance of the neoadjuvant rectal (NAR) score to the outcome of neoadjuvant chemotherapy alone for locally advanced rectal cancer

    Mukai, T; Uehara, K; Aiba, T; Ogura, A; Tsuzuki, T; Tanaka, A; Sando, M; Ohara, N; Sato, Y; Hattori, N; Nakayama, G; Kodera, Y; Nagino, M

    SURGERY TODAY   50 巻 ( 8 ) 頁: 912 - 919   2020年8月

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  66. Tumor Location Is Associated With the Prevalence of <i>Braf</i> And <i>Pik3ca</i> Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan

    Taniguchi, H; Uehara, K; Nakayama, G; Nakayama, H; Aiba, T; Hattori, N; Kataoka, M; Nakano, Y; Kawase, Y; Okochi, O; Matsuoka, H; Utsunomiya, S; Sakamoto, E; Mori, Y; Umeda, S; Shikano, T; Komori, K; Tajika, M; Kadowaki, S; Muro, K; Yatabe, Y

    TRANSLATIONAL ONCOLOGY   13 巻 ( 7 ) 頁: 100786   2020年7月

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  67. Novel Prognostic Implications of DUPAN-2 in the Era of Initial Systemic Therapy for Pancreatic Cancer

    Sunagawa, Y; Yamada, S; Sato, Y; Morimoto, D; Sonohara, F; Takami, H; Inokawa, Y; Hayashi, M; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   27 巻 ( 6 ) 頁: 2081 - 2089   2020年6月

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  68. Fraser extracellular matrix complex subunit 1 promotes liver metastasis of gastric cancer

    Umeda, S; Kanda, M; Miwa, T; Tanaka, H; Tanaka, C; Kobayashi, D; Hayashi, M; Yamada, S; Nakayama, G; Koike, M; Kodera, Y

    INTERNATIONAL JOURNAL OF CANCER   146 巻 ( 10 ) 頁: 2865 - 2876   2020年5月

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    記述言語:英語  

    DOI: 10.1002/ijc.32705

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  69. Clinical impact of additional therapy for residual pancreatic cancer

    Yamada, S; Sonohara, F; Tashiro, M; Murotani, K; Takami, H; Hayashi, M; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujii, T; Kodera, Y

    SURGERY TODAY   50 巻 ( 5 ) 頁: 440 - 448   2020年5月

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  70. Characteristics of Lung Metastasis as an Initial Recurrence Pattern After Curative Resection of Pancreatic Cancer

    Morimoto, D; Yamada, S; Sonohara, F; Takami, H; Hayashi, M; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    PANCREAS   49 巻 ( 5 ) 頁: 699 - 705   2020年5月

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  71. Optimized Cutoff Value of Serum Squamous Cell Carcinoma Antigen Concentration Accurately Predicts Recurrence After Curative Resection of Squamous Cell Carcinoma of the Esophagus

    Kanda, M; Koike, M; Shimizu, D; Tanaka, C; Kobayashi, D; Hattori, N; Hayashi, M; Omae, K; Yamada, S; Nakayama, G; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   27 巻 ( 4 ) 頁: 1233 - 1240   2020年4月

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  72. Exploration of Exosomal Micro RNA Biomarkers Related to Epithelial-to-Mesenchymal Transition in Pancreatic Cancer

    Sonohara, F; Yamada, S; Takeda, S; Hayashi, M; Suenaga, M; Sunagawa, Y; Tashiro, M; Takami, H; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    ANTICANCER RESEARCH   40 巻 ( 4 ) 頁: 1843 - 1853   2020年4月

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  73. Clinical Implications of Naples Prognostic Score in Patients with Resected Pancreatic Cancer

    Nakagawa, N; Yamada, S; Sonohara, F; Takami, H; Hayashi, M; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   27 巻 ( 3 ) 頁: 887 - 895   2020年3月

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  74. Randomized phase II trial of CAPOX with continuous versus intermittent use of oxaliplatin as an adjuvant chemotherapy after curative resection of stage II/III colon cancer (CCOG-1302 study)

    Nakamura, M; Nakayama, G; Ishigure, K; Mashita, N; Yokoyama, H; Hattori, N; Uehara, K; Yamada, S; Koike, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   38 巻 ( 4 )   2020年2月

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    Web of Science

  75. Predictive value of the modified systemic inflammation score in patients undergoing curative resection of squamous cell carcinoma of the esophagus

    Kanda, M; Koike, M; Shimizu, D; Tanaka, C; Kobayashi, D; Sonohara, F; Takami, H; Inokawa, Y; Hattori, N; Hayashi, M; Yamada, S; Nakayama, G; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   38 巻 ( 4 )   2020年2月

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  76. A prospective trial to evaluate treatment effects of a β-hydroxy-β-methylbutyrate containing nutrient for leakage a the anastomotic site after esophagectomy

    Kanda, M; Koike, M; Fukaya, M; Miyata, K; Tanaka, C; Kobayashi, D; Hayashi, M; Yamada, S; Nakayama, G; Murotani, K; Fujiwara, M; Nagino, M; Kodera, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   82 巻 ( 1 ) 頁: 33 - 37   2020年2月

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  77. The Significance of Molecular Biomarkers on Clinical Survival Outcome Differs Depending on Colon Cancer Sidedness

    Hirabayashi, S; Hayashi, M; Nakayama, G; Mii, S; Hattori, N; Tanabe, H; Kanda, M; Tanaka, C; Kobayashi, D; Yamada, S; Koike, M; Fujiwara, M; Takahashi, M; Kodera, Y

    ANTICANCER RESEARCH   40 巻 ( 1 ) 頁: 201 - 211   2020年1月

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  78. Phase II study of capecitabine plus oxaliplatin (CapOX) as adjuvant chemotherapy for locally advanced rectal cancer (CORONA II)

    Hattori, N; Nakayama, G; Uehara, K; Aiba, T; Ishigure, K; Sakamoto, E; Tojima, Y; Kanda, M; Kobayashi, D; Tanaka, C; Yamada, S; Koike, M; Fujiwara, M; Nagino, M; Kodera, Y

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   25 巻 ( 1 ) 頁: 118 - 125   2020年1月

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  79. Peritoneal Lavage Tumor DNA as a Novel Biomarker for Predicting Peritoneal Recurrence in Pancreatic Ductal Adenocarcinoma

    Suenaga, M; Fujii, T; Yamada, S; Hayashi, M; Shinjo, K; Takami, H; Niwa, Y; Sonohara, F; Shimizu, D; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kondo, Y; Kodera, Y

    PANCREAS   48 巻 ( 10 ) 頁: 1528 - 1528   2019年11月

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    Web of Science

  80. Level of Melanotransferrin in Tissue and Sera Serves as a Prognostic Marker of Gastric Cancer

    Sawaki, K; Kanda, M; Umeda, S; Miwa, T; Tanaka, C; Kobayashi, D; Hayashi, M; Yamada, S; Nakayama, G; Omae, K; Koike, M; Kodera, Y

    ANTICANCER RESEARCH   39 巻 ( 11 ) 頁: 6125 - 6133   2019年11月

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  81. Expression, Function, and Prognostic Value of MAGE-D4 Protein in Esophageal Squamous Cell Carcinoma

    Uno, Y; Kanda, M; Sato, Y; Shimizu, D; Umeda, S; Hattori, N; Hayashi, M; Tanaka, C; Kobayashi, D; Yamada, S; Nakayama, G; Motoyama, S; Koike, M; Kodera, Y

    ANTICANCER RESEARCH   39 巻 ( 11 ) 頁: 6015 - 6023   2019年11月

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  82. Comparison of non-invasive liver reserve and fibrosis models: Implications for surgery and prognosis for hepatocellular carcinoma

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    HEPATOLOGY RESEARCH   49 巻 ( 11 ) 頁: 1305 - 1315   2019年11月

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    記述言語:英語  

    DOI: 10.1111/hepr.13400

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  83. Establishment of Peritoneal and Hepatic Metastasis Mouse Xenograft Models Using Gastric Cancer Cell Lines

    Miwa, T; Kanda, M; Umeda, S; Tanaka, H; Shimizu, D; Tanaka, C; Kobayashi, D; Hayashi, M; Yamada, S; Nakayama, G; Koike, M; Kodera, Y

    IN VIVO   33 巻 ( 6 ) 頁: 1785 - 1792   2019年11月

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  84. Feasibility of subtotal esophagectomy with systematic lymphadenectomy in selected elderly patients with esophageal cancer; a propensity score matching analysis

    Kanda, M; Koike, M; Tanaka, C; Kobayashi, D; Hayashi, M; Yamada, S; Nakayama, G; Omae, K; Kodera, Y

    BMC SURGERY   19 巻 ( 1 ) 頁: 143   2019年10月

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  85. Randomized phase II trial of CAPOX with planned oxaliplatin stop-and-go strategy as adjuvant chemotherapy after curative resection of colon cancer (CCOG-1302 study)

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    ANNALS OF ONCOLOGY   30 巻   2019年10月

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  86. Novel implications of combined arterial resection for locally advanced pancreatic cancer in the era of newer chemo-regimens

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    EJSO   45 巻 ( 10 ) 頁: 1895 - 1900   2019年10月

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  87. Biological and conditional factors should be included when defining criteria for resectability for patients with pancreatic cancer

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    HPB   21 巻 ( 9 ) 頁: 1211 - 1218   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.hpb.2019.01.012

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  88. Functions of FRAS1 as a driver gene of liver metastasis from gastric cancer analyzed by the genome editing technology

    Umeda, S; Kanda, M; Tanaka, H; Sonohara, F; Takami, H; Hattori, N; Hayashi, M; Tanaka, C; Kobayashi, D; Yamada, S; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    CANCER RESEARCH   79 巻 ( 13 )   2019年7月

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    記述言語:日本語  

    DOI: 10.1158/1538-7445.AM2019-863

    Web of Science

  89. Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy

    Miwa, T; Kanda, M; Tanaka, C; Kobayashi, D; Hayashi, M; Yamada, S; Nakayama, G; Koike, M; Kodera, Y

    JOURNAL OF GASTRIC CANCER   19 巻 ( 2 ) 頁: 183 - 192   2019年6月

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  90. Homeobox C10 Influences on the Malignant Phenotype of Gastric Cancer Cell Lines and its Elevated Expression Positively Correlates with Recurrence and Poor Survival

    Miwa, T; Kanda, M; Umeda, S; Tanaka, H; Tanaka, C; Kobayashi, D; Suenaga, M; Hayashi, M; Yamada, S; Nakayama, G; Koike, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   26 巻 ( 5 ) 頁: 1535 - 1543   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-019-07166-5

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  91. Neoadjuvant CAPOX and bevacizumab alone for locally advanced rectal cancer: long-term results from the N-SOG 03 trial

    Tomida, A; Uehara, K; Hiramatsu, K; Maeda, A; Sakamoto, E; Okada, Y; Kurumiya, Y; Nakayama, G; Nakamura, M; Aiba, T; Nagino, M

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   24 巻 ( 4 ) 頁: 403 - 410   2019年4月

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    DOI: 10.1007/s10147-018-1372-6

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  92. Increased Expression of <i>DNAJC12</i> is Associated with Aggressive Phenotype of Gastric Cancer

    Uno, Y; Kanda, M; Miwa, T; Umeda, S; Tanaka, H; Tanaka, C; Kobayashi, D; Suenaga, M; Hattori, N; Hayashi, M; Yamada, S; Nakayama, G; Fujiwara, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   26 巻 ( 3 ) 頁: 836 - 844   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-018-07149-y

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  93. Prediction of peritoneal recurrences of gastric cancer by qPCR analysis of peritoneal lavage fluids.

    Nakanishi, K; Kanda, M; Umeda, S; Tanaka, C; Kobayashi, D; Hayashi, M; Yamada, S; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   37 巻 ( 4 )   2019年2月

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    記述言語:日本語  

    DOI: 10.1200/JCO.2019.37.4_suppl.52

    Web of Science

  94. Identification of a serum-based miRNA signature for response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy

    Niwa, Y; Yamada, S; Sonohara, F; Kurimoto, K; Hayashi, M; Tashiro, M; Iwata, N; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF TRANSLATIONAL MEDICINE   17 巻 ( 1 ) 頁: 1   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s12967-018-1762-6

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  95. Perioperative and prognostic implication of albumin-bilirubin-TNM score in Child-Pugh class A hepatocellular carcinoma

    Sonohara, F; Yamada, S; Tanaka, N; Suenaga, M; Takami, H; Hayashi, M; Niwa, Y; Sugimoto, H; Hattori, N; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    ANNALS OF GASTROENTEROLOGICAL SURGERY   3 巻 ( 1 ) 頁: 65 - 74   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ags3.12212

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  96. A New Biomarker for Peritoneal Lavage Using Digital PCR in Patients with Pancreatic Ductal Adenocarcinoma

    Suenaga, M; Yamada, S; Hayashi, M; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    CANCER SCIENCE   109 巻   頁: 650 - 650   2018年12月

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    Web of Science

  97. Copine 5 expression predicts prognosis following curative resection of esophageal squamous cell carcinoma

    Umeda, S; Kanda, M; Koike, M; Tanaka, H; Miwa, T; Tanaka, C; Kobayashi, D; Suenaga, M; Hayashi, M; Yamada, S; Nakayama, G; Kodera, Y

    ONCOLOGY REPORTS   40 巻 ( 6 ) 頁: 3772 - 3780   2018年12月

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    DOI: 10.3892/or.2018.6742

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  98. Troponin I2 as a specific biomarker for prediction of peritoneal metastasis in gastric cancer

    Sawaki, K; Kanda, M; Suenaga, M; Hayashi, M; Tanaka, C; Yamada, S; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    CANCER SCIENCE   109 巻   頁: 765 - 765   2018年12月

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  99. Pattern-specific Transcriptomics Identifies ASGR2 as a Predictor of Hematogenous Recurrence of Gastric Cancer

    Tanaka, H; Kanda, M; Suenaga, M; Hayashi, M; Tanaka, C; Yamada, S; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    CANCER SCIENCE   109 巻   頁: 1128 - 1128   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  100. Integrated multigene expression panel to prognosticate patients with gastric cancer

    Kanda, M; Miwa, T; Umeda, S; Tanaka, C; Hayashi, M; Suenaga, M; Yamada, S; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    CANCER SCIENCE   109 巻   頁: 769 - 769   2018年12月

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  101. FRAS1 expression reflects the malignancy potential of gastric cancer

    Umeda, S; Kanda, M; Tanaka, C; Yamada, S; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    CANCER SCIENCE   109 巻   頁: 1128 - 1128   2018年12月

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  102. Prognostic Impact of Portal System Invasion in Pancreatic Cancer Based on Image Classification

    Morimoto, D; Yamada, S; Murotani, K; Sonohara, F; Takami, H; Suenaga, M; Hayashi, M; Niwa, Y; Tashiro, M; Hattori, N; Iwata, N; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    PANCREAS   47 巻 ( 10 ) 頁: 1350 - 1356   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MPA.0000000000001186

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  103. Treatment strategy of intraperitoneal and systemic chemotherapy combined with gastrectomy for gastric cancer with peritoneal metastasis

    Kobayashi, D; Kanda, M; Tanaka, C; Sonohara, F; Suenaga, M; Takami, H; Hattori, N; Niwa, Y; Hayashi, M; Yamada, S; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 巻   頁: 98 - 98   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  104. Transanal extended rectal surgery with lateral pelvic lymph node dissection

    Aiba, T; Uehara, K; Mukai, T; Hattori, N; Nakayama, G; Nagino, M

    TECHNIQUES IN COLOPROCTOLOGY   22 巻 ( 11 ) 頁: 893 - 894   2018年11月

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    DOI: 10.1007/s10151-018-1891-1

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  105. Clinical Impact of Neoadjuvant Therapy on Nutritional Status in Pancreatic Cancer

    Tashiro, M; Yamada, S; Sonohara, F; Takami, H; Suenaga, M; Hayashi, M; Niwa, Y; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   25 巻 ( 11 ) 頁: 3365 - 3371   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-018-6699-8

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  106. Expression of sushi domain containing two reflects the malignant potential of gastric cancer

    Umeda, S; Kanda, M; Miwa, T; Tanaka, H; Tanaka, C; Kobayashi, D; Suenaga, M; Hattori, N; Hayashi, M; Yamada, S; Nakayama, G; Fujiwara, M; Kodera, Y

    CANCER MEDICINE   7 巻 ( 10 ) 頁: 5194 - 5204   2018年10月

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    DOI: 10.1002/cam4.1793

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  107. A longitudinal study of a new point-of-care nerve conduction device for quantitative assessment of chemotherapy-induced peripheral neurotoxicity

    Matsuoka, A; Maeda, O; Mitsuma, A; Uehara, K; Nakayama, G; Nagino, M; Kodera, Y; Ando, Y

    ANNALS OF ONCOLOGY   29 巻   2018年10月

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  108. Comparison of the Survival Outcomes of Pancreatic Cancer and Intraductal Papillary Mucinous Neoplasms

    Yamada, S; Fujii, T; Hirakawa, A; Takami, H; Suenaga, M; Hayashi, M; Niwa, Y; Hattori, N; Iwata, N; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    PANCREAS   47 巻 ( 8 ) 頁: 974 - 979   2018年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MPA.0000000000001110

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  109. Pattern-Specific Transcriptomics Identifies <i>ASGR2</i> as a Predictor of Hematogenous Recurrence of Gastric Cancer

    Tanaka, H; Kanda, M; Miwa, T; Tanaka, C; Kobayashi, D; Umeda, S; Shibata, M; Suenaga, M; Hattori, N; Hayashi, M; Iwata, N; Yamada, S; Nakayama, G; Fujiwara, M; Kodera, Y

    MOLECULAR CANCER RESEARCH   16 巻 ( 9 ) 頁: 1420 - 1429   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1158/1541-7786.MCR-17-0467

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  110. Impact of the Controlling Nutritional Status Score on the Prognosis After Curative Resection of Pancreatic Ductal Adenocarcinoma

    Kato, Y; Yamada, S; Suenaga, M; Takami, H; Niwa, Y; Hayashi, M; Iwata, N; Kanda, M; Tanaka, C; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    PANCREAS   47 巻 ( 7 ) 頁: 823 - 829   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MPA.0000000000001105

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  111. Randomized Phase II Trial of CapOX plus Bevacizumab and CapIRI plus Bevacizumab as First-Line Treatment for Japanese Patients with Metastatic Colorectal Cancer (CCOG-1201 Study)

    Nakayama, G; Mitsuma, A; Sunagawa, Y; Ishigure, K; Yokoyama, H; Matsui, T; Nakayama, H; Nakata, K; Ishiyama, A; Asada, T; Umeda, S; Ezaka, K; Hattori, N; Takami, H; Kobayashi, D; Tanaka, C; Kanda, M; Yamada, S; Koike, M; Fujiwara, M; Fujii, T; Murotani, K; Ando, Y; Kodera, Y

    ONCOLOGIST   23 巻 ( 8 ) 頁: 919 - 927   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1634/theoncologist.2017-0640

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  112. Troponin I2 as a Specific Biomarker for Prediction of Peritoneal Metastasis in Gastric Cancer

    Sawaki, K; Kanda, M; Miwa, T; Umeda, S; Tanaka, H; Tanaka, C; Kobayashi, D; Suenaga, M; Hattori, N; Hayashi, M; Yamada, S; Nakayama, G; Fujiwara, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   25 巻 ( 7 ) 頁: 2083 - 2090   2018年7月

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    DOI: 10.1245/s10434-018-6480-z

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  113. Clinical Implications of Lysyl Oxidase-Like Protein 2 Expression in Pancreatic Cancer

    Tanaka, N; Yamada, S; Sonohara, F; Suenaga, M; Hayashi, M; Takami, H; Niwa, Y; Hattori, N; Iwata, N; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    SCIENTIFIC REPORTS   8 巻 ( 1 ) 頁: 9846   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-018-28253-9

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  114. A Multicenter Clinical Phase II Study of FOLFOXIRI Plus Bevacizumab as First-line Therapy in Patients With Metastatic Colorectal Cancer: QUATTRO Study

    Oki, E; Kato, T; Bando, H; Yoshino, T; Muro, K; Taniguchi, H; Kagawa, Y; Yamazaki, K; Yamaguchi, T; Tsuji, A; Iwamoto, S; Nakayama, G; Emi, Y; Touyama, T; Nakamura, M; Kotaka, M; Sakisaka, H; Yamanaka, T; Kanazawa, A

    CLINICAL COLORECTAL CANCER   17 巻 ( 2 ) 頁: 147 - 155   2018年6月

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    DOI: 10.1016/j.clcc.2018.01.011

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  115. A novel dual-marker expression panel for easy and accurate risk stratification of patients with gastric cancer

    Kanda, M; Murotani, K; Tanaka, H; Miwa, T; Umeda, S; Tanaka, C; Kobayashi, D; Hayashi, M; Hattori, N; Suenaga, M; Yamada, S; Nakayama, G; Fujiwara, M; Kodera, Y

    CANCER MEDICINE   7 巻 ( 6 ) 頁: 2463 - 2471   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/cam4.1522

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  116. IDENTIFICATION OF MOLECULES DRIVING HEPATIC METASTASIS FORMATION OF GASTRIC CANCER CELLS

    Kanda, M; Tanaka, C; Kobayashi, D; Suenaga, M; Takami, H; Hattori, N; Niwa, Y; Hayashi, M; Yamada, S; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    GUT   67 巻   頁: A5 - A5   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/gutjnl-2018-IDDFabstracts.12

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  117. Significance of Lysyl oxidase-like 2 gene expression on the epithelial-mesenchymal status of hepatocellular carcinoma

    Ninomiya, G; Yamada, S; Hayashi, M; Takeda, S; Suenaga, M; Takami, H; Kanda, M; Iwata, N; Niwa, Y; Tanaka, C; Kobayashi, D; Fujii, T; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    ONCOLOGY REPORTS   39 巻 ( 6 ) 頁: 2664 - 2672   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3892/or.2018.6349

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  118. Postoperative adalimumab maintenance therapy for Japanese patients with Crohn's disease: a single-center, single-arm phase II trial (CCOG-1107 study)

    Asada, T; Nakayama, G; Tanaka, C; Kobayashi, D; Ezaka, K; Hattori, N; Kanda, M; Yamada, S; Koike, M; Kodera, Y

    SURGERY TODAY   48 巻 ( 6 ) 頁: 609 - 617   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00595-018-1634-y

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  119. Integrated multigene expression panel to prognosticate patients with gastric cancer.

    Kanda M, Murotani K, Tanaka H, Miwa T, Umeda S, Tanaka C, Kobayashi D, Hayashi M, Hattori N, Suenaga M, Yamada S, Nakayama G, Fujiwara M, Kodera Y

    Oncotarget   9 巻 ( 27 ) 頁: 18775-18785   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18632/oncotarget.24661

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  120. Clinical implication of nutrition for neoadjuvant therapy and impact of nutritional support in pancreatic cancer.

    Tashiro, M; Yamada, S; Fujii, T; Hattori, N; Takami, H; Suenaga, M; Niwa, Y; Hayashi, M; Iwata, N; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   36 巻 ( 4 ) 頁: .   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1200/JCO.2018.36.4_suppl.416

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  121. Identification of a novel molecule target for the diagnosis, prediction, and treatment of hepatic metastasis of gastric cancer.

    Kanda, M; Tanaka, H; Miwa, T; Kobayashi, D; Tanaka, C; Takami, H; Hayashi, M; Iwata, N; Niwa, Y; Yamada, S; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   36 巻 ( 4 ) 頁: .   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1200/JCO.2018.36.4_suppl.53

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  122. Randomized phase II trial of CapOX plus bevacizumab versus CapIRI plus bevacizumab as first-line treatment in Japanese patients with metastatic colorectal cancer (CCOG-1201).

    Sasahara, M; Nakayama, G; Ishigure, K; Yokoyama, H; Uehara, K; Ishiyama, A; Matsui, T; Nakayama, H; Kobayashi, D; Umeda, S; Sunagawa, Y; Murotani, K; Ando, Y; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   36 巻 ( 4 ) 頁: .   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1200/JCO.2018.36.4_suppl.781

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  123. Phase II trial of oral S-1 plus bevacizumab for patients with metastatic colorectal cancer refractory to standard chemotherapies (CCOG-1105 study).

    Ezaka, K; Nakayama, G; Yokoyama, H; Matsui, T; Umeda, S; Sunagawa, Y; Murotani, K; Ando, Y; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   36 巻 ( 4 ) 頁: .   2018年2月

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    DOI: 10.1200/JCO.2018.36.4_suppl.841

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  124. Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer.

    Yamada, S; Fujii, T; Takano, N; Takami, H; Suenaga, M; Niwa, Y; Hayashi, M; Iwata, N; Kanda, M; Kobayashi, D; Tanaka, C; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   36 巻 ( 4 ) 頁: .   2018年2月

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    DOI: 10.1200/JCO.2018.36.4_suppl.523

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  125. Effectiveness of plasma activated lactated Ringer's solution on pancreatic cancer cells in vitro and in vivo

    Sato, Y; Yamada, S; Takeda, S; Kanda, M; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    CANCER SCIENCE   109 巻   頁: 707 - 707   2018年1月

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  126. Efficacy and safety of CapeIRI plus bevacizumab therapy as a second-line treatment for patients with metastatic colorectal cancer

    Sunagawa, Y; Nakayama, G; Hattori, N; Ezaka, K; Uda, H; Umeda, S; Sato, B; Yamada, S; Sugimito, H; Koike, M; Kodera, Y

    ANNALS OF ONCOLOGY   28 巻   頁: .   2017年11月

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  127. Evaluation and proposal of novel resectability criteria for pancreatic cancer established by the Japan Pancreas Society

    Yamada, S; Fujii, T; Takami, H; Hayashi, M; Iwata, N; Kanda, M; Tanaka, C; Sugimoto, H; Nakayama, G; Koike, M; Fujiwara, M; Kodera, Y

    SURGERY   162 巻 ( 4 ) 頁: 784 - 791   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.surg.2017.04.023

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  128. <i>FAM46C</i> Serves as a Predictor of Hepatic Recurrence in Patients with Resectable Gastric Cancer

    Tanaka, H; Kanda, M; Shimizu, D; Tanaka, C; Kobayashi, D; Hayashi, M; Iwata, N; Yamada, S; Fujii, T; Nakayama, G; Sugimoto, H; Fujiwara, M; Niwa, Y; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   24 巻 ( 11 ) 頁: 3438 - 3445   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1245/s10434-016-5636-y

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  129. Involvement of the immunoregulator MZB1 in progression of gastric cancer

    Tanaka, Y; Kanda, M; Tanaka, C; Kobayashi, D; Tanaka, H; Takami, H; Hayashi, M; Iwata, N; Niwa, Y; Yamada, S; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    ANNALS OF ONCOLOGY   28 巻   頁: .   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  130. Primary efficacy results and clinical impact of UGT1A1 genotype on safety from a Phase II study of FOLFOXIRI plus bevacizumab in patients with metastatic colorectal cancer: The QUATTRO study

    Bando, H; Kato, T; Yoshino, T; Muro, K; Yamazaki, K; Yamaguchi, T; Oki, E; Iwamoto, S; Tsuji, A; Nakayama, G; Emi, Y; Touyama, T; Nakamura, M; Kotaka, M; Kagawa, Y; Taniguchi, H; Sakisaka, H; Yamanaka, T; Kanazawa, A

    ANNALS OF ONCOLOGY   28 巻   頁: .   2017年9月

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  131. Usefulness of preoperative estimated glomerular filtration rate to predict complications after curative gastrectomy in patients with clinical T2-4 gastric cancer

    Tanaka, Y; Kanda, M; Tanaka, C; Kobayashi, D; Mizuno, A; Iwata, N; Hayashi, M; Niwa, Y; Takami, H; Yamada, S; Fujii, T; Nakayama, G; Sugimoto, H; Fujiwara, M; Kodera, Y

    GASTRIC CANCER   20 巻 ( 4 ) 頁: 736 - 743   2017年7月

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    DOI: 10.1007/s10120-016-0657-6

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  132. Stapling an extracorporeal Billroth-I anastomosis by the complete double stapling technique after laparoscopy-assisted distal gastrectomy.

    Tanaka C, Fujiwara M, Kanda M, Murotani K, Iwata N, Hayashi M, Kobayashi D, Yamada S, Nakayama G, Sugimoto H, Koike M, Fujii T, Kodera Y

    Asian journal of endoscopic surgery   10 巻 ( 2 ) 頁: 137 - 142   2017年5月

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    DOI: 10.1111/ases.12357

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  133. The efficacy and safety of CapeOX plus bevacizumab therapy followed by capecitabine plus bevacizumab maintenance therapy in patients with metastatic colorectal cancer: a multi-center, single-arm, phase II study (CCOG-0902)

    Nakayama, G; Ishigure, K; Yokoyama, H; Uehara, K; Kojima, H; Ishiyama, A; Hayashi, N; Takano, N; Hattori, N; Kobayashi, D; Tanaka, C; Hayashi, M; Kanda, M; Yamada, S; Sugimoto, H; Koike, M; Fujiwara, M; Fujii, T; Murotani, K; Ando, Y; Kodera, Y

    BMC CANCER   17 巻 ( 1 ) 頁: 243   2017年4月

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    DOI: 10.1186/s12885-017-3245-1

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  134. Clinical impact of sarcopenia on prognosis in pancreatic ductal adenocarcinoma: A retrospective cohort study

    Ninomiya, G; Fujii, T; Yamada, S; Yabusaki, N; Suzuki, K; Iwata, N; Kanda, M; Hayashi, M; Tanaka, C; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    INTERNATIONAL JOURNAL OF SURGERY   39 巻   頁: 45 - 51   2017年3月

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    DOI: 10.1016/j.ijsu.2017.01.075

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  135. The Charlson age comorbidity index predicts prognosis in patients with resected pancreatic cancer

    Asano, T; Yamada, S; Fujii, T; Yabusaki, N; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    INTERNATIONAL JOURNAL OF SURGERY   39 巻   頁: 169 - 175   2017年3月

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    DOI: 10.1016/j.ijsu.2017.01.115

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  136. <i>GPR155</i> Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer

    Shimizu, D; Kanda, M; Tanaka, H; Kobayashi, D; Tanaka, C; Hayashi, M; Iwata, N; Niwa, Y; Takami, H; Yamada, S; Fujii, T; Nakayama, G; Fujiwara, M; Kodera, Y

    SCIENTIFIC REPORTS   7 巻   頁: 42089   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/srep42089

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    PubMed

  137. The Charlson age comorbidity index to predict prognosis in patients with resected pancreatic cancer.

    Asano, T; Fujii, T; Yamada, S; Yabusaki, N; Ninomiya, G; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   35 巻 ( 4 ) 頁: .   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1200/JCO.2017.35.4_suppl.495

    Web of Science

  138. Tumor infiltrative pattern predicts sites of recurrence after curative gastrectomy for gastric cancer.

    Kanda, M; Kobayashi, D; Tanaka, C; Yamada, S; Fujii, T; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   35 巻 ( 4 )   2017年2月

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    記述言語:日本語  

    DOI: 10.1200/JCO.2017.35.4_suppl.38

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  139. The efficacy and safety of CapeOX plus bevacizumab therapy with a planned oxaliplatin stop-and-go strategy in patients with metastatic colorectal cancer: A multicenter, single-arm, phase II study (CCOG-0902 study).

    Sunakawa, Y; Nakayama, G; Ishigure, K; Yokoyama, H; Uehara, K; Kanda, M; Murotani, K; Fujii, T; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   35 巻 ( 4 )   2017年2月

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    記述言語:日本語  

    DOI: 10.1200/JCO.2017.35.4_suppl.795

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  140. Inverse probability of treatment weighting analysis of upfront surgery versus neoadjuvant chemoradiotherapy followed by surgery for pancreatic adenocarcinoma with arterial abutment.

    Fujii, T; Yamada, S; Murotani, K; Takami, H; Hayashi, M; Kanda, M; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   35 巻 ( 4 )   2017年2月

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    記述言語:日本語  

    DOI: 10.1200/JCO.2017.35.4_suppl.440

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  141. Clinical impact of sarcopenia on prognosis in pancreatic ductal adenocarcinoma.

    Ninomiya, G; Fujii, T; Yamada, S; Asano, T; Takano, N; Takami, H; Iwata, N; Kanda, M; Niwa, Y; Hayashi, M; Kobayashi, D; Tanaka, C; Nakayama, G; Sugimoto, H; Fujiwara, M; Koike, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   35 巻 ( 4 )   2017年2月

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    記述言語:日本語  

    DOI: 10.1200/JCO.2017.35.4_suppl.259

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  142. Clinical implication of inflammation-based prognostic score and perioperative nutrition control in pancreatic cancer.

    Takano, N; Yamada, S; Fujii, T; Tashiro, M; Tanaka, N; Morimoto, D; Ninomiya, G; Niwa, Y; Takami, H; Iwata, N; Hayashi, M; Kanda, M; Tanaka, C; Kobayashi, D; Nakayama, G; Sugimoto, H; Koike, M; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   35 巻 ( 4 )   2017年2月

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    DOI: 10.1200/JCO.2017.35.4_suppl.390

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  143. Conversion surgery for unresectable gastric cancer following complete response of distant metastasis by systemic chemotherapy.

    Kobayashi, D; Kanda, M; Tanaka, C; Iwata, N; Hayashi, M; Yamada, S; Nakayama, G; Sugimoto, H; Koike, M; Fujii, T; Fujiwara, M; Kodera, Y

    JOURNAL OF CLINICAL ONCOLOGY   35 巻 ( 4 )   2017年2月

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    記述言語:日本語  

    DOI: 10.1200/JCO.2017.35.4_suppl.152

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  144. The protein arginine methyltransferase 5 promotes malignant phenotype of hepatocellular carcinoma cells and is associated with adverse patient outcomes after curative hepatectomy

    Shimizu, D; Kanda, M; Sugimoto, H; Shibata, M; Tanaka, H; Takami, H; Iwata, N; Hayashi, M; Tanaka, C; Kobayashi, D; Yamada, S; Nakayama, G; Koike, M; Fujiwara, M; Fujii, T; Kodera, Y

    INTERNATIONAL JOURNAL OF ONCOLOGY   50 巻 ( 2 ) 頁: 381 - 386   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3892/ijo.2017.3833

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  145. <i>PAX5</i> gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma

    Kurimoto, K; Hayashi, M; Guerrero-Preston, R; Koike, M; Kanda, M; Hirabayashi, S; Tanabe, H; Takano, N; Iwata, N; Niwa, Y; Takami, H; Kobayashi, D; Tanaka, C; Yamada, S; Nakayama, G; Sugimoto, H; Fujii, T; Fujiwara, M; Kodera, Y

    EPIGENETICS   12 巻 ( 10 ) 頁: 865 - 874   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/15592294.2017.1365207

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▼全件表示

科研費 2

  1. クローン病術後抗TNFα抗体維持療法の有効性と安全性に関する検討

    研究課題/研究課題番号:22K08768  2022年4月 - 2026年3月

    科学研究費助成事業  基盤研究(C)

    中山 吾郎, 山村 健史, 梅田 晋一, 中村 正直, 服部 憲史

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    担当区分:研究代表者 

    配分額:4290000円 ( 直接経費:3300000円 、 間接経費:990000円 )

    クローン病は小腸・大腸を中心とした消化管に慢性肉芽腫性炎症を生じる原因不明の炎症性腸疾患であり,厚生労働省より特定疾患(指定難病)に指定されている.現在クローン病を完治させる治療法はなく,薬物治療により活動性をコントロールし,患者のQoLを高めることが治療の主体である.一方で腸管切除を含む手術が必要となる症例も多く,また術後再発による再手術率が高いことは大きな問題である.本研究では難治性腸管病変に対する手術後の寛解維持療法としての生物学的製剤の再発抑制効果と安全性を臨床第2相試験として検証し,科学的根拠に基づく新たな治療戦略を創世することを目標とする.
    クローン病は小腸・大腸を中心とした消化管に慢性肉芽腫性炎症を生じる原因不明の炎症性腸疾患であり、厚生労働省より特定疾患に指定されている。現在クローン病を完治させる治療法はなく、薬物治療により活動性をコントロールし、患者のQoLを高めることが治療の主体である。一方で腸管切除を含む手術が必要となる症例も多く、また術後再発による再手術率が高いことは大きな問題である。本研究では難治性腸管病変に対する手術後の寛解維持療法としての生物学的製剤の再発抑制効果と安全性を臨床第2相試験として検証し、科学的根拠に基づく新たな治療戦略を創世することを目標とする。
    当施設の炎症性腸疾患治療センターを中心に内科・外科共同でクローン病の難治性腸管病変に対する術後ウステキヌマブ寛解維持療法の有効性と安全性について評価を行った。2022年度は、過去に当院でクローン病に対する腸管切除・吻合術後にウステキヌマブが投与された患者のうち、術前に抗TNF-α抗体薬の投与歴があるクローン病患者(コホートA)16例、術前に抗TNF-α抗体薬の投与歴がないクローン病患者(コホートB)11例を対象として、術後1年の臨床的再発に関して後方視的に検討を行い、本研究の妥当性について検討を行った。各コホートの再発率は、19%/10%と良好であり、この結果をもとに本研究の実施計画書を作成した。2023年度は研究実施計画書を名古屋大学医学部附属病院IRBへ提出し、認可を取得の上で症例登録を開始する(予定登録数50例)。
    2022年度は、本研究の妥当性の検証及び名古屋大学医学部附属病院IRBに提出する研究実施計画書作成を目的とし、historical dataを用いた後方視的検討を行い、本研究の実施計画書を作成した。
    2023年度は研究実施計画書を名古屋大学医学部附属病院IRBへ提出し、認可を取得の上で症例登録を開始する(予定登録数50例)。プロトコール治療(術後、2-4 週の期間にウステキヌマブを開始し、原則内視鏡的もしくは臨床的な再発が確認されるまで継続)及び内視鏡的評価を含むフォローアップは、研究代表者及び研究分担者を中心に実施する。2024年度には、主要評価項目である術後1年内視鏡的吻合部再発率について、2025年度には副次的評価項目(臨床的再発率,再手術率,各無再発生存期間,治療成功期間,有害事象発生割合等)について適宜評価・解析を行い、関連学会や論文において結果を公表する。

  2. クローン病術後抗TNFα抗体維持療法の有効性と安全性に関する検討

    研究課題/研究課題番号:15K10133  2015年4月 - 2019年3月

    科学研究費助成事業  基盤研究(C)

    中山 吾郎, 藤井 努, 小寺 泰弘

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    担当区分:研究代表者 

    配分額:3900000円 ( 直接経費:3000000円 、 間接経費:900000円 )

    クローン病の腸管病変に対する術後抗TNF-α抗体薬(アダリムマブ)維持療法の再発抑制効果を明らかにする目的で臨床研究を実施した.26例を対象とし,術後8週以内にアダリムマブを導入し,その有効性と安全性について検討を行った.主要評価項目である術後1年の内視鏡的吻合部再発率は31%であった.また,術後1年の臨床的再発率は17%で,再手術を必要とする症例は認めなった.再発リスク因子に関する解析では,術前の抗TNF-α抗体薬の使用,特にアダリムマブの治療歴を有することが独立した再発リスク因子であった.今後,再発リスクとなる症例群を対象とした新たな術後治療に関する臨床研究を計画中である.
    クローン病の術後寛解維持療法としてアダリムマブの有効性を検討した国内初めての前方視的臨床研究であり,術後再発を抑制するための新たな治療戦略を示唆する成果であると考える.