Updated on 2021/12/06

写真a

 
ITO, Sachiko
 
Organization
Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology Lecturer
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Lecturer

Degree 1

  1. 博士(医学) ( 2005.6   名古屋大学 ) 

Research Interests 2

  1. 腫瘍免疫

  2. 免疫学

Research Areas 1

  1. Life Science / Immunology  / Immunology

 

Papers 47

  1. CD4+ T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice. Reviewed

    Yasuda Y, Iwama S, Sugiyama D, Okuji T, Kobayashi T, Ito M, Okada N, Enomoto A, Ito S, Yan Y, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Goto M, Suga H, Banno R, Takahashi M, Nishikawa H, Arima H.

    Sci Transl Med.   Vol. 13 ( 593 ) page: eabb7495.   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scitranslmed.abb7495

  2. Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors. Reviewed

    Kobayashi T, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Ito M, Ito S, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Nishikawa H, Arima H.

    J Immunother Cancer.   Vol. 9 ( 5 ) page: e002493   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jitc-2021-002493

  3. Newly emerged immunogenic neoantigens in established tumors enable hosts to regain immunosurveillance in a T cell-dependent manner Reviewed

    Muramatsu T, Noguchi T, Sugiyama D, Kanada Y, Fujimaki K, Ito S, Gotoh M, Nishikawa H.

    Int Immunol.   Vol. 33 ( 1 ) page: 39 - 48   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/intimm/dxaa049

  4. Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids. Reviewed

    Tokunaga A, Sugiyama D, Maeda Y, Warner AB, Panageas KS, Ito S, Togashi Y, Sakai C, Wolchok JD, Nishikawa H

    J Exp Med.     2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20190738

  5. Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils. Reviewed

    Tanaka Y, Ito S, Isobe K.

    Sci Rep.   Vol. 6   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep23920

  6. GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation Reviewed

    Ito S, Tanaka Y, Oshino R, Okado S, Hori M, Isobe KI.

    Cell Death Dis.   Vol. 7   2016

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/cddis.2016.116

  7. GADD34 Promotes Tumor Growth by Inducing Myeloid-derived Suppressor Cells. Reviewed

    Liu L, Ito S, Nishio N, Sun Y, Tanaka Y, Isobe K.

    Anticancer Res.   Vol. 36 ( 9 ) page: 4623 - 4628   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

  8. Transfusion of CD206+ M2 Macrophages Ameliorates Antibody-Mediated Glomerulonephritis in Mice. Reviewed

    Du Q, Tsuboi N, Shi Y, Ito S, Sugiyama Y, Furuhashi K, Endo N, Kim H, Katsuno T, Akiyama S, Matsuo S, Isobe KI, Maruyama S.

    Am J Pathol.   Vol. 186 ( 12 ) page: 3176-3188   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

  9. Thymic Epithelial Cells Induced from Pluripotent Stem Cells by a Three-Dimensional Spheroid Culture System Regenerates Functional T Cells in Nude Mice. Reviewed

    Okabe M, Ito S, Nishio N, Tanaka Y, Isobe K.

    Cell Reprogram.   Vol. 17 ( 5 ) page: 368-75   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/cell.2015.0006

  10. Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice. Reviewed

    Tanaka Y, Ito S, Oshino R, Chen N, Nishio N, Isobe K.

    Br J Cancer.   Vol. 113 ( 4 ) page: 669-679   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bjc.2015.263

  11. GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy. Reviewed

    Ito S, Tanaka Y, Oshino R, Aiba K, Thanasegaran S, Nishio N, Isobe K.

    Sci Rep.     2015

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep08327

  12. Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice. Reviewed

    Himeno T, Kamiya H, Naruse K, Cheng Z, Ito S, Shibata T, Kondo M, Kato J, Okawa T, Fujiya A, Suzuki H, Kito T, Hamada Y, Oiso Y, Isobe K, Nakamura J.

    J Diabetes Res     2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2015/257230

  13. Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model. Reviewed

    Chen N, Nishio N, Ito S, Tanaka Y, Sun Y, Isobe K.

    Cancer Immunol Immunother.   Vol. 64 ( 6 ) page: 777-789   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

  14. Enhancement of the acrolein-induced production of reactive oxygen species and lung injury by GADD34. Reviewed

    Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Liu L, Isobe K.

    Oxid Med Cell Longev     2015

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2015/170309

  15. GADD34 Facilitates Cell Death Resulting from Proteasome Inhibition. Reviewed

    Liu L, Ito S, Nishio N, Sun Y, Chen N, Tanaka Y, Isobe K

    Anticancer Res.   Vol. 35 ( 10 ) page: 5317-24   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

  16. Loss of GADD34 induces early age-dependent deviation to the myeloid lineage. Reviewed

    Nishio N, Ito S, Isobe K.

    Immunol Cell Biol.     2014.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/icb.2013.78. Epub 2013 Nov 19.

  17. Acrolein induced both pulmonary inflammation and the death of lung epithelial cells. Reviewed

    Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Isobe K.

    Toxicol Lett.   Vol. 229 ( 2 ) page: 384-92   2014.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  18. Recruitment of Gr1+CD11b +F4/80 + Population in the Bone Marrow and Spleen by Irradiation-Induced Pulmonary Damage. Reviewed

    Thanasegaran S, Ito S, Nishio N, Uddin MN, Sun Y, Isobe KI.

    Inflammation     2014

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10753-014-9952-8

  19. Negative regulation of GADD34 on myofibroblasts during cutaneous wound healing. Reviewed

    Liu L, Nishio N, Ito S, Tanaka Y, Isobe K.

    Biomed Res Int.     2014

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2014/137049.

  20. Establishment of Self-Renewable GM-CSF-Dependent Immature Macrophages In Vitro from Murine Bone Marrow Reviewed

    Ito S, Tanaka Y, Nishio N, Thanasegaran S, Isobe K.

    PLoS One     2013.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0076943

  21. Overexpression of L1CAM is Associated with Tumor Progression and Prognosis via ERK Signaling in Gastric Cancer Reviewed

    Ito T, Yamada S, Tanaka C, Ito S, Murai T, Kobayashi D, Fujii T, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y.

    Annals of Surgical Oncology     2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-013-3246-5

  22. No immunogenicity of IPS cells in syngeneic host studied by in vivo injection and 3D scaffold experiments. Reviewed

    Thanasegaran S, Cheng Z, Ito S, Nishio N, Isobe K.

    Biomed Res Int.     2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2013/378207

  23. iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis. Reviewed

    Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamashita JK, Ouchi N, Honda H, Isobe K, Murohara T.

    Sci Rep.     2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep01418.

  24. Characteristics of cardiac aging in C57BL/6 mice Reviewed

    Zhao Cheng, Sachiko Ito, Naomi Nishio, Suganya Thanasegaran, He Fang, Ken-ichi Isobe

    Experimental Gerontology   Vol. 48   page: 341–348   2013

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  25. Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice. Reviewed

    Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, Kondo M, Tsunekawa S, Naruse K, Hamada Y, Ozaki N, Cheng Z, Kito T, Suzuki H, Ito S, Oiso Y, Nakamura J, Isobe K.

    Cell Transplant   Vol. 22 ( 10 ) page: 1763-1783   2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3727/096368912X657710.

  26. Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice. Reviewed

    Himeno T, Kamiya H, Naruse K, Cheng Z, Ito S, Kondo M, Okawa T, Fujiya A, Kato J, Suzuki H, Kito T, Hamada Y, Oiso Y, Isobe K, Nakamura J.

    Biomed Res Int.     2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2013/259187.

  27. Autophagic activity in thymus and liver during aging. Reviewed

    Uddin MN, Nishio N, Ito S, Suzuki H, Isobe K.

    Age   Vol. 34 ( 1 ) page: 75-85   2012.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11357-011-9221-9.

  28. Analysis of beta-Amyloid Peptide -Binding Proteins in Microglial Cells Reviewed

    Sachiko Ito, Naomi Nishio, Ken-chi Isobe

    The Open Geriatric Medicine Journal   Vol. 5   page: 1-6   2012

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  29. Transplantation of Neural Crest Like Cells Derived from induced Pluripotent Stem Cells Improves Diabetic Polyneuropathy in Mice. Reviewed

    Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, Kondo M, Tsunekawa S, Naruse K, Hamada Y, Ozaki N, Cheng Z, Kito T, Suzuki H, Ito S, Oiso Y, Nakamura J, Isobe KI.

    Cell Transplantation     2012

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3727/096368912X657710

  30. Aging in the mouse and perspectives of rejuvenation through induced pluripotent stem cells (iPSCs).

    Isobe K, Cheng Z, Ito S, Nishio N.

    Results Probl Cell Differ   Vol. 55   page: 413-427   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

  31. Comparative angiogenic activities of induced pluripotent stem cells derived from young and old mice. Reviewed

    Suzuki H, Shibata R, Kito T, Yamamoto T, Ishii M, Nishio N, Ito S, Isobe K, Murohara T.

    PLoS One   Vol. 7 ( 6 )   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0039562. Epub 2012 Jun 27.

  32. Dextran sulphate sodium increases splenic Gr1(+)CD11b(+) cells which accelerate recovery from colitis following intravenous transplantation. Reviewed

    Zhang R, Ito S, Nishio N, Cheng Z, Suzuki H, Isobe KI.

    Clin Exp Immunol.   Vol. 164 ( 3 ) page: 417-427   2011

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2249.2011.04374.x.

  33. Gadd34 induces autophagy through the suppression of the mTOR pathway during starvation. Reviewed

    Uddin MN, Ito S, Nishio N, Suganya T, Isobe K.

    Biochem Biophys Res Commun.   Vol. 407 ( 4 ) page: 692-698   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

  34. Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells Reviewed

    Zhao Cheng, Sachiko Ito, Naomi Nishio et al.

    Journal of Molecular Cell Biology   Vol. 3 ( 2 ) page: 91-98   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

  35. GADD34 suppresses wound healing by upregulating expression of myosin IIA. Reviewed

    Tanaka C, Ito S, Nishio N, Kodera Y, Sakurai H, Suzuki H, Nakao A, Isobe K.

    Transgenic Res.   Vol. 19 ( 4 ) page: 637-645   2010.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  36. Toxic effects of d-galactose on thymus and spleen that resemble aging. Reviewed

    Uddin MN, Nishio N, Ito S, Suzuki H, Isobe KI.

    J Immunotoxicol     page: 1-9   2010.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  37. Antibodies to wounded tissue enhance cutaneous wound healingImmunology. Reviewed

    Nishio N, Ito S, Suzuki H, Isobe K.

    Immunology   Vol. 128 ( 3 ) page: 369-380   2009.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  38. Injection of bleomycin in newborn induces autoimmune salivalitis that is transferred by CD4T cells Reviewed

    Ishikawa H, Ito S, Nishio N, Yuzawa Y, Matsuo S, Isobe K.

    Immunol Cell Biol.   Vol. 87   page: 351-358   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

  39. *Inhibition of reactive oxygen species down-regulates protein synthesis in RAW 264.7 Reviewed

    Kimura K, Ito S, Nagino M, Isobe K

    Biochem Biophys Res Commun   Vol. 372   page: 272-275   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

  40. Thymic involution correlates with severe ulcerative colitis induced by oral administration of dextran sulphate sodium in C57BL/6 mice but not in BALB/c mice. Reviewed

    Sasaki S, Ishida Y, Nishio N, Ito S, Isobe K.

    Inflammation   Vol. 579   page: 319-328   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

  41. *Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway. Reviewed

    Ito S, Kimura K, Haneda M, Ishida Y, Sawada M, Isobe K.

    Experimental Gerontology   Vol. 42   page: 532-537   2007

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  42. Age-dependent changes in dopaminergic projections from the substantia nigra pars compacta to the neostriatum Reviewed

    Ishida Y, Okawa Y, Ito S, Shirokawa T, Isobe K.

    Neuroscience Letters   Vol. 418   page: 257-261   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

  43. *Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via the PI3K/Akt and/or ERK pathway Reviewed

    Ito S, Sawada M, Haneda M, Ishida Y, Isobe K.

    Neurosceience Research   Vol. 56   page: 294-299   2006

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  44. Cellular and systemic defense system against age-promoting stimuli

    Isobe K, Ito S, Haneda M, Ishida Y

    Nagoya Journal of Medical Science   Vol. 68   page: 9-18   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  45. Analysis of growth hormone receptor polymorphism in Japanese semisuper centenarians

    Du Y, Hirose N, Ping J, Ishida Y, Kojima T, Arai Y, Inagaki H, GondoY, Sakaki Y, Haneda M, Ito S, Isobe K.

    Geriatrics and Gerontology International   Vol. 6   page: 82-86   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  46. *Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells Reviewed

    Ito S, Sawada M, Haneda M, Fujii S, Oh-Hashi K, Kiuchi K, Takahashi M, Isobe K.

    FEBS Letters   Vol. 579   page: 1995-2000   2005

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  47. Effects of hyperbaric oxygen on GDNF expression and apoptosis in spinal cord injury. Reviewed

    Yu Y, Matsuyama Y, Yanase M, Ito S, Adachi K, Satake K, Ishiguro N, Kiuchi K.

    Neuroreport   Vol. 15   page: 2369-2373   2004

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    Language:English   Publishing type:Research paper (scientific journal)  

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Books 2

  1. がん免疫の基礎

    伊藤 佐知子 西川 博嘉( Role: Joint author)

    日本医師会雑誌  2019.2 

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    Total pages:5   Language:Japanese

  2. Surgical Trauma & Immunological Responses

    ( Role: Sole author)

    2011.6 

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    Language:Japanese

Presentations 1

  1. がんと免疫〜がん免疫療法の進展〜

    伊藤佐知子

    日本医師会生涯教育講座  2019.9.7  名古屋内科医会

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    Event date: 2019.9

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:名古屋市  

Research Project for Joint Research, Competitive Funding, etc. 3

  1. 免疫チェックポイント阻害によるT細胞活性化と耐性機構のモデル動物による解析

    2019.4 - 2022.3

    国立研究開発法人国立がん研究センター がん研究開発費 

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    Grant type:Competitive

  2. 先端的がん免疫モニタリング法開発体制に関する研究

    2016.4 - 2019.3

    国立研究開発法人国立がん研究センター がん研究開発費 

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    Grant type:Competitive

  3. T細胞応答の多様性回復による がん免疫併用療法の開発

    2016 - 2017

    日本医療研究 開発機構研究費 (革新的がん医療実用化研究事業) 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. 自然免疫応答および炎症関連性癌発症におけるGADD34の機能解析

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

    伊藤佐知子

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    Authorship:Principal investigator 

  2. 細胞増殖・移動と栄養制御ストレスに対する細胞防御におけるGADD34の機能解析

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

    伊藤佐知子

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    Authorship:Principal investigator 

  3. 老化と栄養制御、創傷治癒におけるGADD34の遺伝子欠損マウスを用いた機能解析

    2010.4 - 2012.3

    科学研究費補助金  若手研究(B)

    伊藤 佐知子

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    Authorship:Principal investigator 

  4. SST―REXによるミクログリア由来Aβ結合蛋白質の発現クローニングと機能解析

    2007 - 2009

    科学研究費補助金  若手研究(B)

    伊藤 佐知子

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    Authorship:Principal investigator 

 

Teaching Experience (On-campus) 15

  1. 免疫と生体防御

    2021

  2. 基盤医科学実習(スーパーベーシックトレーニング)

    2021

  3. 免疫と生体防御

    2020

  4. 基盤医科学実習(スーパーベーシックトレーニング)

    2020

  5. 免疫と生体防御

    2019

  6. 基盤医科学実習(スーパーベーシックトレーニング)

    2019

  7. 免疫と生体防御

    2018

  8. 免疫と生体防御

    2017

  9. 免疫と生体防御

    2016

  10. 免疫と生体防御 実習

    2015

  11. 免疫と生体防御 実習

    2014

  12. 免疫と生体防御 実習

    2013

  13. 免疫と生体防御 実習

    2012

  14. 免疫と生体防御 実習

    2011

  15. 免疫と生体防御 実習

    2010

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