Updated on 2024/11/26

写真a

 
KASUYA, Hideki
 
Organization
Graduate School of Medicine Program in Integrated Medicine Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor
Profile
Professor of International Medical Education; Vice Dean of Medical School, Director: Office of International Affairs, Director: Laboratory of Cancer Immunotherapy; Full Member: FACS (Faculty of the American College of Surgery), Board Member:Japanese Society for Gene and Cell Therapy, Board Member:Japanese Medical University International Collaborative Assembly, Board Member:Nagoya University Medical Association. From 2000-2003, Postdoctoral fellow at the Massachusetts General Hospital, Harvard Medical School (Department of Surgery). Current research interests include cancer immunotherapy for pancreatic cancer and comparison of doctoral education systems around the world, and in 2015 he established Japan's first joint doctoral degree program in medicine with the University of Adelaide.

Degree 3

  1. FACS ( 2010.10   American College of Surgeon ) 

  2. A Philosophy of Doctor ( 2000.3   Nagoya University ) 

  3. A Doctor of Medicine ( 1990.3   Aichi Medical University ) 

Research Areas 4

  1. Others / Others  / Laboratory Animal Studies

  2. Others / Others  / Virology

  3. Others / Others  / Digestive Organ Surgery

  4. Others / Others  / Human Genetics

Current Research Project and SDGs 2

  1. Cancer Treatment with Oncolytic viruses and Immune Cell Therapy

  2. Comparison of PhD Education Worldwide, Medical Education

Research History 18

  1. The Chinese University of Hong Kong   Clinical Medicine   Emeritus Professor

    2018.4

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    Country:China

  2. Nagoya University   Professor

    2017.6

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    Country:Japan

  3. Nagoya University   Professor

    2017.6

  4. Nagoya University   Graduate School of Medicine

    2016.4

  5. Nagoya University   Graduate School of Medicine   Ofice of International Affair, Chairman

    2013.4

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences   Program in function Construction Medicine

    1996.4 - 2000.3

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    Country: Japan

  2. Aichi Medical University   Faculty of Medicine   Medicine

    1984.4 - 1990.3

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    Country: Japan

Professional Memberships 10

  1. American Association for Cancer Research

  2. American Society of Clinical Oncology

  3. Fellow of American College of Surgeons(FACS)

  4. Japan Surgical Society

  5. Japanese Society of Gastroenterological Surgery

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Awards 3

  1. Journal of Gene Medicine Award

    2009  

  2. Marie Curie Award

    2006  

  3. Out standing Intellectuals Award

    2003  

 

Papers 72

  1. STING activator 2′3′-cGAMP enhanced HSV-1-based oncolytic viral therapy

    Sibal, PA; Matsumura, S; Ichinose, T; Bustos-Villalobos, I; Morimoto, D; Eissa, IR; Abdelmoneim, M; Aboalela, MAM; Mukoyama, N; Tanaka, M; Naoe, Y; Kasuya, H

    MOLECULAR ONCOLOGY   Vol. 18 ( 5 ) page: 1259 - 1277   2024.5

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  2. The Impact of Metformin on Tumor-Infiltrated Immune Cells: Preclinical and Clinical Studies

    Abdelmoneim, M; Aboalela, MA; Naoe, Y; Matsumura, S; Eissa, IR; Bustos-Villalobos, I; Sibal, PA; Takido, Y; Kodera, Y; Kasuya, H

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 24 ( 17 )   2023.9

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  3. Novel new cell therapy of chimeric antigen receptors into dendritic cells

    Naoe, Y; Abdelmoneim, MA; Aboalela, M; Eissa, IR; Matsumura, S; Kasuya, H

    CANCER SCIENCE   Vol. 114   page: 997 - 997   2023.2

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  4. Expression of CAR Targets on Solid Tumors by Armed Oncolytic virus has synergetic effect on CAR-T cell therapy

    Aboalela, MA; Abdelmoneim, MA; Naoe, Y; Matsumura, S; Kasuya, H

    CANCER SCIENCE   Vol. 114   page: 994 - 994   2023.2

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  5. Expression of CAR Targets on Solid Tumors by Armed Oncolytic virus has synergetic effect on CAR-T cell therapy

    Aboalela, MA; Abdelmoneim, MA; Naoe, Y; Matsumura, S; Kasuya, H

    CANCER SCIENCE   Vol. 114   page: 1419 - 1419   2023.2

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Books 9

  1. 遺伝子治療開発研究ハンドブック第2版

    粕谷英樹 直江吉則 松村繁 ItzelBustos Villalobos ( Role: Contributor ,  腫瘍溶解性ウィルスの臨床試験の進め方とArmed-C-REV(HF10)の研究開発)

    (株)エヌ・ティー・エス  2023  ( ISBN:978-4-86043-840-1

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    Responsible for pages:p403-p410   Language:Japanese

  2. 現代医学65巻2号・癌免疫療法トピックス

    粕谷 英樹,一ノ瀬 亨,直江 吉則,松村 繁,Itzel Bustos,炭竈 誠二,長谷川 仁紀,Branko Aleksic( Role: Joint author)

    愛知県医師会  2017.12 

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    Language:Japanese

  3. Innovation of Diagnosis and Treatment for Pancreatic Cancer Part 4, Chap. 18 The Potential of Oncolytic Virus Therapy for Pancreatic Cancer

    Hideki Kasuya( Role: Joint author)

    Springer  2017.8 

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    Language:English Book type:Scholarly book

  4. 遺伝子医学MOOK 31号 がん免疫療法 - What's now and what's next? 第2章の4の3) 腫瘍溶解性ウイルスHF10による再発乳がん多発結節症例, 切除不能進行膵がん症例に対する臨床研究

    粕谷 英樹, 直江 吉則, 一ノ瀬 亨, 廣岡 芳樹, 後藤 秀実, 田中 舞紀( Role: Joint author)

    (株)メディカル ドゥ  2017.7 

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    Language:Japanese Book type:Scholarly book

  5. 次世代がん治療 ~発症・転移メカニズムからがん免疫療法・ウイルス療法、診断法まで~

    粕谷 英樹 他( Role: Joint author)

    (株)エヌ・ティー・エス  2017.6 

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    Language:Japanese Book type:Scholarly book

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Presentations 5

  1. Two New Strategies to Improve the Limitations of Cellular Therapy for Solid Tumors

    Hideki Kasuya, Mona Alhussein Mostafa Aboalela, Yoshinori Naoe, Shigeru Matsumura

    2024.7 

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    Event date: 2024.7

  2. The Alteration of the surrounding immunological tumor environment by Oncolytic viruses.

    Hideki Kasuya, Yoshinori Naoe, Shigeru Matsumura

    2023.9 

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    Event date: 2023.9

  3. The novel armed oncolytic HSV exhibits a strong antitumor effect that completely regresses tumors Invited International conference

    Hideki Kasuya

    2022.10 

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    Event date: 2022.10

    Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  4. International Collaborative Program in Comprehensive Medical Science between Nagoya University and University of Freiburg Invited International conference

    2022.10.7 

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    Event date: 2022.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Keio University   Country:Japan  

  5. Combination of multiple cytokines armed oncolytic HSV virus in the treatment of metastatic Tumor Invited International conference

    Hideki Kasuya

    Oncolytic Virotherapy Summit  2021.10 

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    Event date: 2021.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:online(hybrid,Boston)   Country:United States  

Research Project for Joint Research, Competitive Funding, etc. 9

  1. 腫瘍溶解性ウイルスHF10を使用した、からだに優しい癌治療

    2008.7 - 2009.3

    学内共同研究 

  2. 長期間持続的効果の確認された腫瘍溶解性ウイルスを用いた癌臨床試験

    2008.6 - 2009.5

    学内共同研究 

  3. 安全でより強力な抗腫瘍効果を持つ新規ヘルペスウイルスベクターの開発

    2007.12 - 2008.12

    学内共同研究 

  4. 単純ヘルペスウイルスを用いた癌のウイルス療法

    2007.4 - 2008.3

    学内共同研究 

  5. Deveropment of inovative cancer therapy using mutannt herpes virus, and Phase I/II study

    2007.4

    Cooperative Research within an Affiliated University or Institute 

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KAKENHI (Grants-in-Aid for Scientific Research) 15

  1. 固形癌に対するCAR-T、ウイルス療法の併用による新規免疫療法の開発

    Grant number:21H02999  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(B)

    粕谷 英樹, 直江 吉則, 松村 繁

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    Authorship:Principal investigator 

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

    本研究は、腫瘍溶解性ウイルスとCAR-T細胞との併用でより強力な癌免疫療法を確立することを目的とし、T細胞の集族を向上させるケモカインRANTESとT細胞誘導標識抗原とを同時に発現する次世代型腫瘍溶解性ウイルスを開発することによって、CAR-T細胞を意図的に腫瘍に集簇させ、これに派生する以下の問いに解答を得ることで医療に貢献すると共に、幅広く研究者に有益な学術的情報を提供する。
    本研究は細胞療法や免疫チェックポイント阻害薬が十分な効果を発揮できないアンメットメディカルニーズ難治固形癌の新たな治療法を開発することを目的に、癌抗原とケモカインを同時に搭載した次世代型腫瘍溶解性ウイルスと標識癌抗原を認識するCAR-Tを新たに創造することである。昨年度、野生型HSV1のg34.5遺伝子座にCMVプロモーターにより発現するヒトMesothelin(MSLN)を導入した腫瘍溶解性ウイルス作成した(HSV1-MSLN)。このウイルスは感染した腫瘍でMSLNが発現することを確認した。また、ヒトMSLNに対する一本鎖抗体にCD28膜貫通領域、さらに、CD3細胞内ドメインをタンデムに結合させたレトロウイルスベクターを作成、マウスT細胞に感染させ、ヒトMSLNに対するCAR-T細胞を作製した。このCAR-T細胞はMSLN発現細胞と共培養することにより活性化することを確認した。本年度は、HSV1-MSLNとCAR-T細胞の併用効果をin vivoにおいて評価した。HSV1-MSLNは担癌マウスに投与しても体重減少を起こさなかったことから、安全性は高かった。マウス皮下にマウス膵臓癌細胞Pan02を移植し、腫瘍の大きさが100mm3の大きさに達した時点でHSV1-MSLNを腫瘍内に投与した。その後CAR-T細胞を腫瘍内に投与し、腫瘍の増殖を経時的に測定した。その結果、HSV1-MSLN単独ならびにHSV1-MSLN/CAR-T細胞併用は腫瘍の増殖を著しく抑制した。しかし、HSV1-MSLN/CAR-T細胞併用はHSV1-MSLN単独よりも強い抗腫瘍効果を発揮したが、HSV1-MSLN単独でも強い抗腫瘍効果を発揮したため、優位な併用効果を確認することが出来なかった。
    ヒトMSLN発現腫瘍溶解性ウイルスとヒトMSLN認識CAR-T細胞を併用することにより、in vivoにおいて強い抗腫瘍効果を確認することができた。
    本年度は抗原発現腫瘍溶解性ウイルスとCAR-T細胞の併用効果をin vivoで確認できた。今後、併用治療がウイルス単独治療より優位な効果を発揮するかどうか、ウイルスの投与量、投与スケジュールを検討し併用効果を確認する予定である。また、より強い併用効果を発揮するためにウイルスにCAR-T細胞を腫瘍内に誘導するためのケモカインを搭載する。

  2. Oncolytic virus targeting tumor associated mesenchymal stem cells

    Grant number:18H02691  2018.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Matsumura Shigeru

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    One of the mechanisms for immune suppression in pancreatic tumors is the recruitment of mesenchymal stem cells (MSC), which turn into tumor-associated fibroblasts. C-REV, our oncolytic virus, has been shown to dramatically change the tumor microenvironment. Here, we examined whether C-REV has the ability to kill MSC in the tumor tissue. A naturally mutated attenuated HSV1, C-REV cannot replicate inside the healthy normal cells. However, we found that C-REV can infect and replicate in the MSC. Furthermore, C-REV treatment on the MSC-injected pancreatic tumors showed decreased numbers of MSC in the mouse model.

  3. TCR sequencing of tumor infiltrating T cells using iPS cell technology

    Grant number:17K19696  2017.6 - 2019.3

    Grant-in-Aid for Challenging Research (Exploratory)

    Naoe Yoshinori

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    By collecting tumor-specific cytotoxic T cells infiltrating the mouse tumor and introducing Yamanaka factor, it was possible to obtain a cell population that proliferates without anti-CD3 antibody stimulation. These cells were judged as iPS cells because they proliferated without TCR stimulation. In addition, we confirmed a gene rearrangement of the TCRb in all the proliferating cells examined. From the above, it was suggested that cells proliferating without anti-CD3 stimulation are derived from T cells. In addition, we tried to establish iPS cells using human peripheral cytotoxic T cells, but the establishment efficiency was low. In the future, we will investigate culture conditions and try to improve the establishment efficiency.

  4. Role of immune cells in anti-tumor effect of HF10

    Grant number:16H05413  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kasuya Hideki

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    Authorship:Principal investigator 

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

    HF10 showed a strong antitumor effect on squamous cell carcinoma cell line SCC7. Furthermore, a synergistic antitumor effect was observed in combination with the PD-L1 antibody. Next, we examined what kind of immune cells infiltrated into the tumor. As a result, infiltration of T cells, macrophages, NK cells and dendritic cells was observed at a high rate in the tumors administered in the HF10 and HF10 / anti-PD-L1 antibody combination group. On the other hand, in non-treated tumors, T cell infiltration was found at a high rate. From this, infiltration of immune cells into the tumor was observed in the HF10 and HF10/anti-PD-L1 antibody combination group, which suggested that infiltration of these immune cells was involved in the enhancement of the combined effect.

  5. HF10ウイルスの抗腫瘍効果における新たな免疫因子の役割

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(B)

    粕谷英樹

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    Authorship:Principal investigator 

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Industrial property rights 1

  1. キメラ標的因子受容体(PCT出願)

    粕谷英樹

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    Application no:PCT/JP2021/043978  Date applied:2021.11

    Patent/Registration no:PCT/JP2021/043978