Faculty Profiles - HONDA, Takashi

Papers - HONDA, Takashi

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*Hepatitis B e antigen and hepatitis B surface antigen seroclearance with emergence of lamivudine-associated mutation and core mutation after elevation of CD4 in a patient with hepatitis B and HIV Reviewed International journal

Honda T, Ishigami M, Luo F, Ishizu Y, Kuzuya T, Hayashi K, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Katano Y, Goto H.

Internal Medicine Vol. 54 ( 6 ) page： 585-590 2015.6

Endoscopic treatment of esophageal varices on hemophilic patients with liver cirrohosis Reviewed International journal

Ishizu Y, Ishigami M, Kuzuya T, Honda T, Hayashi K, Goto H.

Gastrointest Endosc Vol. 81 ( 4 ) page： 1059-1060 2015.4

Progressive fibrosis significantly correlates with hepatocellular carcinoma in patients with a sustained virological response. Reviewed International journal

Tachi Y, Hirai T, Miyata A, Ohara K, Iida T, Ishizu Y, Honda T, Kuzuya T, Hayashi K, Ishigami M, Goto H.

Hepatol Res. Vol. 45 ( 2 ) page： 238 - 246 2015.1

Association of interleukin 28B polymorphism and mutations in the NS5A region of hepatitis C virus genotype 2 with interferon responsiveness Reviewed International journal

Hayashi K, Katano Y, Ishuzu Y, Kuzuya T, Honda T, Ishigami M, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Yoshioka K, Toyoda H, Kumada T, Goto H.

J Gastroenterol Hepatol Vol. 30 ( 1 ) page： 178-183 2015.1

Transarterial chemoembolization for hepatocellular carcinoma: A review of techniques. Reviewed International journal

Imai N, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, Hirooka Y, Goto H

World journal of hepatology Vol. 6 ( 12 ) page： 844 - 50 2014.12

Frequent incidence of escape mutants after successful hepatitis B vaccine response and stopping of nucleos(t)ide analogues in liver transplant recipients Reviewed International journal

Ishigami M, Honda T, Ishizu Y, Onishi Y, Kamei H, Hayashi K, Ogura Y, Hirooka Y, Goto H.

Liver Transpl. Vol. 20 ( 10 ) page： 1211-1120 2014.10

A pediatric case of hepatitis B virus subgenotype A2 in Japan. Reviewed International journal

Hayashi K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Ito Y, Kimura H, Katano Y, Goto H

Clinical journal of gastroenterology Vol. 6 ( 5 ) page： 383 - 5 2013.10

The relationship between the fever and the disappearance or decrease of lesion contrast on contrast enhanced CT images after 2 weeks of sorafenib treatment for patients with advanced hepatocellular carcinoma Reviewed

KUZUYA Teiji, ISHIGAMI Masatoshi, NIINOMI Takurou, IMAI Norihiro, ACHIWA Kouichi, ARAKAWA Takahiro, YAMADA Keiichi, NAKANO Satoshi, ISHIZU Yoji, HONDA Takashi, HAYASHI Kazuhiko, ISHIKAWA Tetsuya, NAKANO Isao, KATANO Yoshiaki, ITOH Akihiro, HIROOKA Yoshiki, GOTO Hidemi

Kanzo Vol. 54 ( 7 ) page： 505 - 506 2013.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Hepatology

We investigated the relationship between the fever and the disappearance or decrease of lesion contrast on contrast enhanced CT images after 2 weeks of sorafenib treatment for patients with advanced hepatocellular carcinoma (HCC). Subjects were 64 patients who began sorafenib therapy. Contrast enhanced CT images were taken at baseline and after 2 weeks of sorafenib treatment. In patients with fever, the ratio of patients demonstrating the disappearance or decrease of lesion contrast on contrast enhanced CT images was significantly higher than in those without fever (91.3% and 61.0%, respectively, p=0.010, Fisher's exact probability test). The results suggested the relationship between the fever and contrast change on contrast enhanced CT.

DOI： 10.2957/kanzo.54.505

An increase in lesion density can predict lower local recurrence after transarterial chemoembolization in patients with hepatocellular carcinoma. Reviewed International journal

Imai N, Katano Y, Kuzuya T, Honda T, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Goto H.

Hepatogastroenterology Vol. 60 ( 125 ) page： 965 - 970 2013.6

Pegylated interferon monotherapy in patients with chronic hepatitis C with low viremia and its relationship to mutations in the NS5A region and the single nucleotide polymorphism of interleukin-28B. Reviewed International journal

Hayashi K, Katano Y, Masuda H, Ishizu Y, Kuzuya T, Honda T, Ishigami M, Itoh A, Hirooka Y, Nakano I, Ishikawa T, Urano F, Yoshioka K, Toyoda H, Kumada T, Goto H.

Hepatol Res Vol. 43 ( 6 ) page： 580-588 2013

Clinical trial of percutaneous radio frequency ablation therapy by two-step insertion method using VirtuTRAXTM instrument navigator Reviewed

Kuzuya Teiji, Hayashi Kazuhiko, Ishigami Masatoshi, Ishikawa Tetsuya, Nakano Isao, Katano Yoshiaki, Itoh Akihiro, Hirooka Yoshiki, Izumi Namiki, Goto Hidemi, Ishizu Yoji, Niinomi Takurou, Imai Norihiro, Achiwa Kouichi, Arakawa Takahiro, Yamada Keiichi, Nakano Satoshi, Honda Takashi

Kanzo Vol. 54 ( 12 ) page： 850 - 853 2013

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Hepatology

We performed percutaneous radio frequency ablation (RFA) therapy by two-step insertion method using VirtuTRAXTM (GE Healthcare, USA) instrument navigator. Subjects were 16 patients (23 nodules) with hepatocellular carcinoma. VirtuTRAXTM position sensor was attached to the hilt of 14-gauge outer needle. In all cases, we could perform 17- gauge Cool-tip RFA without the positional gap between the virtual tract and the actual needle which was caused by the deflection of the needle. The reasons without causing the positional gap were that the outer needle was more rigid than Cool-tip needle, and that it was inserted using initial insertion of a 21-gauge guided needle. RFA by two-step insertion method using VirtuTRAXTM is suggested to be more safe and effective than conventional RFA.

DOI： 10.2957/kanzo.54.850

Role of naofen in apoptosis of hepatocytes induced by lipopolysaccharide through mitochondrial signaling in rats Reviewed International journal

Fan JH, Feng GG, Huang L, Tsunekawa K, Honda T, Katano Y, Hirooka Y, Goto H, Kandatsu N, Ando K, Fujiwara Y, Koide T, Okada S, Ishikawa N.

Hepatol Res Vol. 42 ( 7 ) page： 696-705 2012.7

Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C Reviewed International journal

Ishizu Yoji, Katano Yoshiaki, Honda Takashi, Hayashi Kazuhiko, Ishigami Masatoshi, Itoh Akihiro, Hirooka Yoshiki, Nakano Isao, Goto Hidemi

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 27 ( 6 ) page： 1112 - 1116 2012.6

Prevalence of hepatitis C virus genotype 1a in Japan and correlation of mutations in the NS5A region and single-nucleotide polymorphism of interleukin-28B with the response to combination therapy with pegylated-interferon-alpha 2b and ribavirin. Reviewed International journal

Hayashi K, Katano Y, Kuzuya T, Tachi Y, Honda T, Ishigami M, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Urano F, Yoshioka K, Toyoda H, Kumada T, Goto H.

J Med Virol. Vol. 84 ( 3 ) page： 438-444 2012.3

Predictive value of early viral dynamics during peginterferon and ribavirin combination therapy based on genetic polymorphisms near the IL28B gene in patients infected with HCV genotype 1b. Reviewed International journal

Toyoda H, Kumada T, Tada T, Hayashi K, Honda T, Katano Y, Goto H, Kawaguchi T, Murakami Y, Matsuda F.

J Med Virol. Vol. 84 ( 1 ) page： 61-70 2012.1

Association of interleukin 28B and mutations in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy Reviewed International journal

Hayashi Kazuhiko, Katano Yoshiaki, Honda Takashi, Ishigami Masatoshi, Itoh Akihiro, Hirooka Yoshiki, Ishikawa Tetsuya, Nakano Isao, Yoshioka Kentaro, Toyoda Hidenori, Kumada Takashi, Goto Hidemi

LIVER INTERNATIONAL Vol. 31 ( 9 ) page： 1359 - 1365 2011.10

Antiviral combination therapy with peginterferon and ribavirin does not induce a therapeutically resistant mutation in the HCV core region regardless of genetic polymorphism near the IL28B gene. Reviewed International journal

Toyoda H, Kumada T, Hayashi K, Honda T, Katano Y, Goto H, Kawaguchi T, Murakami Y, Matsuda F.

J Med Virol. Vol. 83 ( 9 ) page： 1559-1564 2011.9

Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C. Reviewed International journal

Ishizu Y, Katano Y, Honda T, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Nakano I, Goto H.

J Gastroenterol Hepatol 2011

Association between HCV amino acid substitutions and outcome of peginterferon andribavirin combination therapy in HCV genotype 1b and high viral load. Reviewed International journal

Toyoda H, Kumada T, Tada T, Arakawa T, Hayashi K, Honda T, Katano Y, Goto H.

JGastroenterol Hepatol. Vol. 25 ( 6 ) page： 1072-1078 2010.7

Impact of amino acid substitutions in the hepatitis Cvirus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C. Reviewed International journal

Tachi Y, Katano Y, Honda T, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Nakano I, Samejima Y, Goto H.

Liver Int. Vol. 30 ( 4 ) page： 554-559 2010.4

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Papers - HONDA, Takashi