Updated on 2022/04/24

写真a

 
HONDA, Takashi
 
Organization
Nagoya University Hospital Gastroenterology Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer

Degree 1

  1. 医学博士 ( 2004.3   名古屋大学 ) 

Research Interests 7

  1. B型肝炎

  2. C型肝炎

  3. 非アルコール性脂肪性肝炎(NASH)

  4. 腸内細菌

  5. 肝硬変

  6. 肝癌

  7. アミノ酸代謝

Research Areas 1

  1. Life Science / Gastroenterology  / Gastroenterology

Professional Memberships 5

  1. 日本内科学会   支部評議員

    2003.9

  2. 日本消化器病学会   学会評議員

    2017.1

  3. 日本肝臓学会   評議員

    2011.12

  4. 日本消化器内視鏡学会

    2004.12

  5. 日本超音波学会

    2004.1

Committee Memberships 1

  1. 名古屋大学医学部附属病院治験審査委員会   委員  

    2013.10   

Awards 7

  1. The Best Presenter Award in International Session

    2021.11   JDDW2021   Possible prediction of functional cure by HBV core mutations in patients with chronic hepatitis B

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    Award type:Award from Japanese society, conference, symposium, etc. 

  2. Poster of Distinction for presentation

    2020.11   AASLD2020   AMINO ACID POLYMORPHISM IN HEPATITIS B VIRUS ASSOCIATED WITH NATURAL CLEARANCE OF HBV DNA AND HBsAg

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    Award type:Award from international society, conference, symposium, etc. 

  3. ポスター優秀演題賞

    2019.11   JDDW2019   C型肝癌症例に関連する腸内細菌の検討

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    Award type:Award from Japanese society, conference, symposium, etc. 

  4. 冠Award 「第2回Gilead Sciences Award」

    2017.10   日本肝臓学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  5. 63th AASLD Presidential Poster of Distinction

    2016.5   American Association for the Study of Liver Diseases  

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    Award type:Award from international society, conference, symposium, etc.  Country:United States

  6. AASLD Presidential Poster of Distinction

    2012.11   American Association for the Study of Liver Diseases  

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  7. 日本肝臓学会海外研修スポンサーシップ

    2007.4   社団法人 日本肝臓学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Papers 185

  1. *Differences in the intestinal microbiome associated with diarrhea during lenvatinib treatment for hepatocellular carcinoma Reviewed International journal

    Inukai Y, Yamamoto K, Honda T*, Ito T, Imai N, Ishizu Y, Nakamura M, Kawashima H, Ishigami M.

    Dig Dis.     2022.3

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  2. *Patients with low muscle mass have characteristic microbiome with low potential for amino acid synthesis in chronic liver disease. Reviewed International journal

    Yamamoto K, Ishizu Y, Honda T*, Ito T, Imai N, Nakamura M, Kawashima H, Kitaura Y, Ishigami M, Fujishiro M

    Scientific reports   Vol. 12 ( 1 ) page: 3674   2022.3

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-07810-3

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  3. *Changes in the gut microbiota after hepatitis C virus eradication Reviewed International journal

    Honda T, Ishigami M, Yamamoto K, Takeyama T, Ito T, Ishizu, Y, Kuzuya T, Nakamura M, Kawashima H, Miyahara R, Tetsuya T, Yoshiki Hirooka Y, Fujishiro M

    Scientific Reports     2021.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  4. *Changes in the gut microbiome in relation to the degree of gastric mucosal atrophy before and after <i>Helicobacter pylori</i> eradication. Reviewed International journal

    Furune S, Yamamoto K, Honda T*, Fujiyoshi T, Kakushima N, Furukawa K, Ohno E, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Hirooka Y, Fujishiro M

    Scandinavian journal of gastroenterology     page: 1 - 8   2021.11

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/00365521.2021.2005135

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  5. *Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine. Reviewed International journal

    Yamamoto K, Honda T*, Yokoyama S, Ma L, Kato A, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Kawashima H, Ishigami M, Tsuji NM, Fujishiro M

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver   Vol. 53 ( 11 ) page: 1443 - 1450   2021.11

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.dld.2021.02.013

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  6. *Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure. Reviewed International journal

    Honda T, Yamada N, Murayama A, Shiina M, Aly HH, Kato A, Ito T, Ishizu Y, Kuzuya T, Ishigami M, Murakami Y, Tanaka T, Moriishi K, Nishitsuji H, Shimotohno K, Ishikawa T, Fujishiro M, Muramatsu M, Wakita T, Kato T

    Cellular and molecular gastroenterology and hepatology   Vol. 12 ( 5 ) page: 1583 - 1598   2021.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jcmgh.2021.07.013

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  7. *The relationship between oral-origin bacteria in the fecal microbiome and albumin-bilirubin grade in patients with hepatitis C. Reviewed International journal

    Yamamoto K, Honda T*, Ito T, Ishizu Y, Kuzuya T, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Fujishiro M

    Journal of gastroenterology and hepatology   Vol. 36 ( 3 ) page: 790 - 799   2021.3

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgh.15206

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  8. Changes in Body Composition Predict the Time to Treatment Failure of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma: A Pilot Retrospective Study. Reviewed International journal

    Yamamoto T, Imai N, Kuzuya T, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M

    Nutrition and cancer     page: 1 - 10   2022.3

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    DOI: 10.1080/01635581.2022.2049322

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  9. The impact of the age-adjusted Charlson comorbidity index as a prognostic factor for endoscopic papillectomy in ampullary tumors. Reviewed International journal

    Takada Y, Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Yamamura T, Kakushima N, Furukawa K, Nakamura M, Honda T, Ishigami M, Ito A, Hirooka Y

    Journal of gastroenterology   Vol. 57 ( 3 ) page: 199 - 207   2022.3

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    Language:English   Publisher:Journal of Gastroenterology  

    Background: The prognostic nutritional index (PNI) and Charlson comorbidity index (CCI) have been useful for predicting the prognosis based on nutritional condition and comorbidities in surgery and endoscopic mucosal dissection. The age-adjusted CCI (ACCI) has also been reported to be useful in surgery, but it has not been applied to endoscopic treatment. We therefore clarified the prognostic factors associated with ampullary tumors treated with endoscopic papillectomy (EP). Methods: From January 2003 to December 2020, 236 patients who underwent EP for sporadic ampullary tumors at Nagoya University Hospital were included in this study. The 5-year survival and ability to predict the prognosis were evaluated in terms of the sex, PNI, ACCI, final pathological diagnosis, and intraductal extension. Results: During a median follow-up period of 1558 days, 17 patients died. No patient died of the primary disease. The 5-year survival rate was 91.1%. In a univariate analysis, only a high ACCI (≥ 5) was extracted as a significant prognostic factor (Odds ratio, 12.2; 95% confidence interval, 3.81–39.3; p < 0.001). The 5-year survival rates for a low ACCI (≤ 4) and high ACCI were 96.6% and 73.5%, respectively (p < 0.001). Conclusions: A high ACCI is an important prognostic factor associated with the 5-year survival and a risk of death from other illness. Ampullary tumors suitable for EP are less likely to be a prognostic factor, and treatment-free follow-up may be acceptable in patients with a high ACCI.

    DOI: 10.1007/s00535-022-01853-z

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  10. Multiple cancer type classification by small RNA expression profiles with plasma samples from multiple facilities Reviewed

    Suzuki K., Igata H., Honda T., Kawashima H., Ishigami M., Abe M., Yamamoto Y.

    Cancer Science     2022.2

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  11. Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients. International journal

    Nakamura M, Maeda K, Yamamoto K, Yamamura T, Sawada T, Ishikawa E, Kakushima N, Furukawa K, Iida T, Mizutani Y, Ishikawa T, Ohno E, Honda T, Ishigami M, Kawashima H

    Digestion     page: 1 - 12   2022.2

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    Background: The pathophysiology of ulcerative colitis (UC) remains unclear, but early lesions on the colorectal mucosal surface may play an important role in its etiology. Intestinal mucus samples, including inner and outer layers, are collected by net or brush catheters, but the quality of the samples obtained by each method has not been fully investigated. Objective: The purpose of this study was to compare the microbiome and protein content of intestinal mucus collected by net and brush catheters during colonoscopy. Methods: Intestinal mucus samples from the lower rectum of 4 patients with UC were collected using a net catheter, a brush catheter, and intestinal fluid suction. Microbiome and protein content were analyzed using 16S rRNA gene sequencing and mass spectrometry. Results: The patients demonstrated significant differences in microbiome alpha diversity (p < 0.05), but this difference was not observed between the sampling methods. Net catheter samples demonstrated higher total protein concentrations than brush catheter samples. The brush catheter group had more Lachnospira, a butyrate-producing bacterium, when compared to the net group. The brush catheter group also had more oral bacteria of Staphylococcus and Dialister in those with active phase when compared to the net group. Conclusions: Brush catheters are more likely to collect the intestinal mucus inner layer, whereas net catheters are more likely to collect larger samples that include the outer mucus layer, as well as the intestinal fluid. Two sampling methods with different types of collection of the mucosa may lead to different results among patients with mucosal vulnerabilities.

    DOI: 10.1159/000521929

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  12. Immunoproliferative Small Intestinal Disease Diagnosed by Double-balloon Endoscopy with Biopsy Sampling Reviewed International journal

    Meza Miguel Ricardo Rodríguez, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi

    Internal Medicine   Vol. advpub ( 0 )   2022.2

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    Language:English   Publisher:The Japanese Society of Internal Medicine  

    <p>We herein report an 80-year-old man diagnosed with immunoproliferative small intestine disease (IPSID) via small bowel endoscopy with a biopsy. He developed persistent diarrhea and subsequently presented with hypoproteinemia and moderate anemia. Transanal double-balloon endoscopy showed prominent villous edema in the middle and lower ileum, while a histological examination showed high lymphocyte/plasma cell infiltration in the mucosal layer. Furthermore, an immunostaining analysis showed that CD3 and CD20 were partially positive, while CD138 was diffusely positive. Immunoglobulin A positivity was also observed. He was diagnosed with IPSID and received a nutritional agent and minocycline. After three months, the patients' symptoms improved. </p>

    DOI: 10.2169/internalmedicine.8847-21

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  13. Factors related to delayed adverse events of endoscopic submucosal dissection in the duodenum. Reviewed International journal

    Kawamura T, Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M

    Digestive diseases (Basel, Switzerland)     2022.2

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    DOI: 10.1159/000522362

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  14. Comparison of outcomes between secondary fully covered and uncovered self-expandable metal stents in the treatment of recurrent biliary obstruction of pancreatic cancer. Reviewed International journal

    Kataoka K, Kawashima H, Ohno E, Ishikawa T, Mizutani Y, Iida T, Furukawa K, Nakamura M, Honda T, Ishigami M, Fujishiro M

    Surgical endoscopy     2022.1

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    Background: The overall survival (OS) of pancreatic cancer (PC) has been prolonged by advances in chemotherapy, and the number of cases of recurrent biliary obstruction (RBO) after self-expandable metal stent (SEMS) placement is expected to increase. We herein compared outcomes between secondary fully covered SEMS (FC) and uncovered SEMS (UC) for RBO of PC with FC placed as the 1st SEMS. Methods: Between May 2010 and March 2021, 62 PC patients who underwent SEMS exchange to FC (n = 34) or UC (n = 28) for RBO were retrospectively analyzed. Patient characteristics, OS, time to RBO (TRBO), and stent-related adverse events were compared between the FC and UC groups. Cox’s proportional hazard model was used to identify risk factors for RBO with the 2nd SEMS. Results: There was a significant difference between the FC and UC groups only in the 2nd SEMS diameter. Median OS and TRBO were 195 and 238 days in FC patients and 306 and 455 days in UC patients, respectively, with no significant differences between the two groups. No significant differences were observed in the stent-related adverse event rate. In multivariate analyses, only the 2nd SEMS diameter was significant (P = 0.009). Median TRBO were 455, 238, and 103 days in 10-mm UC, 10-mm FC, and 8-mm UC patients, with 10-mm UC patients having significantly longer TRBO than 10-mm FC and 8-mm UC patients (P = 0.020 and 0.001). Conclusion: SEMS exchange to 10-mm UC may be appropriate for RBO of PC with FC as the 1st SEMS.

    DOI: 10.1007/s00464-021-08981-2

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  15. Differentiation Between Solid Pseudopapillary Neoplasm of the Pancreas and Nonfunctional Pancreatic Neuroendocrine Neoplasm Using Endoscopic Ultrasound. Reviewed International journal

    Kataoka K, Ishikawa T, Ohno E, Mizutani Y, Iida T, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M

    Pancreas   Vol. 51 ( 1 ) page: 106 - 111   2022.1

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    Objectives We investigated the utility of endoscopic ultrasound (EUS) for differentiating between solid pseudopapillary neoplasm of the pancreas (SPN) and pancreatic neuroendocrine neoplasm (PanNEN). Methods A retrospective analysis was performed on 29 and 77 consecutive patients with pathologically proven SPN and nonfunctional PanNEN. In patients who underwent contrast-enhanced harmonic EUS (CH-EUS), lesions were classified into 3 vascular patterns (hypoechoic/isoechoic/hyperechoic), and the presence of "the alveolus nest sign,"which we previously reported as a characteristic feature of SPN on CH-EUS, was also assessed. Results Conventional EUS findings showed that calcification echoes were significantly more frequent in SPN lesions than in PanNEN lesions (19/29 [66%] vs 21/77 [27%], P = 0.001) as was internal isoechogenicity or hyperechogenicity (10/29 [34%] vs 11/77 [14%], P = 0.029). Contrast-enhanced harmonic EUS findings showed that SPN lesions more frequently had the isoechoic or hypoechoic vascular pattern, and significantly more frequently had the alveolus nest sign (18/25 [72%] vs 4/60 [7%], P < 0.001). In a multivariate analysis, the presence of the alveolus nest sign contributed the most to the SPN diagnosis (odds ratio, 70; 95% confidence interval, 6.2-786). Conclusions Endoscopic ultrasound, particularly the presence of the alveolus nest sign on CH-EUS, is useful for differentiating SPN from PanNEN.

    DOI: 10.1097/MPA.0000000000001966

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  16. The influence of hepatitis C virus eradication on hepatocarcinogenesis in patients with hemophilia HCC after HCV eradication in hemophilia Reviewed International journal

    Inukai Yosuke, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    ANNALS OF HEPATOLOGY   Vol. 27 ( 1 ) page: 100545   2022

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    DOI: 10.1016/j.aohep.2021.100545

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  17. Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis Reviewed International journal

    Nakamura M., Yamamura T., Maeda K., Sawada T., Mizutani Y., Ishikawa E., Ishikawa T., Kakushima N., Furukawa K., Ohno E., Kawashima H., Honda T., Ishigami M., Fujishiro M.

    Nagoya Journal of Medical Science   Vol. 84 ( 1 ) page: 169 - 179   2022

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    Language:Japanese   Publisher:Nagoya Journal of Medical Science  

    Ulcerative colitis (UC) is an incurable, chronic inflammatory disease of the large bowel whose etiology and pathogenesis have not yet been comprehensively explained. Tofacitinib is a small molecule Janus kinase inhibitor that was introduced for treating refractory UC. We aimed to examine the efficacy and safety of tofacitinib for the treatment of 18 patients with UC. Continuous treatment rates were 50, 38, and 33% at 8, 24, and 52 weeks, respectively. Overall, 83.3% of these patients showed tumor necrosis factor (TNF) antibody failure status. When the effective status was defined as a Lichtiger index (LI) that decreased by 3 points or more or was less than 4 points and remission status was defined as an LI less than 4 points, the effective and remission rates (%) at 2, 8, and 16 weeks were 55.5 (10/18) and 22.2 (4/18), 38.8 (7/18) and 33.3 (6/18), and 38.8 (7/18) and 38.8 (7/18), respectively. Background characteristics of 2-week responders and non-responders were compared. C-reactive protein level in responders was significantly lower than that in non-responders, and the hemoglobin level in responders was significantly higher than that in non-responders. This study provides preliminary results of the effectiveness of tofacitinib even for TNF antibody and tacrolimus failure patients.

    DOI: 10.18999/nagjms.84.1.169

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  18. Obesity and myosteatosis: the two characteristics of dynapenia in patients with cirrhosis. Reviewed International journal

    Sugiyama Y, Ishizu Y, Ando Y, Yokoyama S, Yamamoto K, Ito T, Imai N, Nakamura M, Honda T, Kawashima H, Ishikawa T, Ishigami M

    European journal of gastroenterology & hepatology   Vol. 33 ( 1S Suppl 1 ) page: e916 - e921   2021.12

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    OBJECTIVE: In patients with liver cirrhosis, the clinical characteristics of dynapenia, a condition in which skeletal muscle mass is maintained but muscle strength is reduced, are not yet known. This study aimed to clarify the characteristics of dynapenia and its impact on quality of life (QOL) in patients with liver cirrhosis. METHODS: We retrospectively analyzed 116 patients with cirrhosis. Based on grip strength and skeletal muscle mass measured by the bioelectrical impedance analysis method, patients were divided into four groups: normal muscle status, dynapenia, pre-sarcopenia (a condition involving only low muscle mass), and sarcopenia. The characteristics of dynapenia and its influence on QOL were examined. RESULTS: Fourteen patients had dynapenia. Liver function did not differ among the four groups. In patients with dynapenia, BMI was highest and computed tomography attenuation of skeletal muscle at the third lumbar spine vertebra was lowest among the four groups. The percentage of patients with both BMI ≥25 kg/m2 and myosteatosis was significantly higher in patients with dynapenia [9/14 (64.3%)] than in those with sarcopenia [2/23 (8.7%), P = 0.004] and pre-sarcopenia [0/18 (0%), P < 0.001] and tended to be higher than those with normal muscle status [16/61 (26.2%), P = 0.065]. The physical QOL in patients with dynapenia was as low as that in those with sarcopenia and significantly lower than that in those with normal muscle status. CONCLUSION: Cirrhotic patients with dynapenia had high BMI and myosteatosis, and impaired physical QOL.

    DOI: 10.1097/MEG.0000000000002303

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  19. Immune-related Liver Injury is a Poor Prognostic Factor in Patients with Nonsmall Cell Lung Cancer Treated with Immune Checkpoint Inhibitors. Reviewed International journal

    Yamamoto T, Ito T, Hase T, Ishigami M, Mizuno K, Yamamoto K, Imai N, Ishizu Y, Honda T, Shibata H, Hatta T, Yogo N, Yasuda S, Toyoda H, Abe T, Kawashima H, Hashimoto N, Fujishiro M

    Cancer investigation     page: 1 - 10   2021.11

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    DOI: 10.1080/07357907.2021.1994586

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  20. Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival Reviewed International journal

    Yamada K., Nakamura M., Yamamura T., Ishikawa E., Iida T., Mizutani Y., Kakushima N., Ishikawa T., Furukawa K., Ohno E., Honda T., Ishigami M., Sawada T., Maeda K., Kawashima H., Furune S., Maeda O., Ando Y., Hase T., Hashimoto N., Yokota K., Akiyama M., Fujishiro M.

    World Journal of Gastroenterology   Vol. 27 ( 41 ) page: 7190 - 7206   2021.11

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    DOI: 10.3748/wjg.v27.i41.7190

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  21. Safety and Efficacy of Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Hepatocellular Carcinoma: First Clinical Outcomes. Reviewed International journal

    Imai N, Yokoyama S, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M

    Anticancer research   Vol. 41 ( 11 ) page: 5817 - 5820   2021.11

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    DOI: 10.21873/anticanres.15399

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  22. The absence of large portal collateral vessels is concerned with spontaneous improvement of cirrhotic portal vein thrombosis. Reviewed International journal

    Yokoyama S, Ishizu Y, Honda T, Imai N, Ito T, Yamamoto K, Tomoyuki T, Ishigami M

    Hepatology research : the official journal of the Japan Society of Hepatology     2021.10

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    DOI: 10.1111/hepr.13725

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  23. Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis Reviewed International journal

    Ryuge Akihiro, Kosugi Tomoki, Maeda Kayaho, Banno Ryoichi, Gou Yang, Zaitsu Kei, Ito Takanori, Sato Yuka, Hirayama Akiyoshi, Tsubota Shoma, Honda Takashi, Nakajima Kazuki, Ozaki Tomoya, Kondoh Kunio, Takahashi Kazuo, Kato Noritoshi, Ishimoto Takuji, Soga Tomoyoshi, Nakagawa Takahiko, Koike Teruhiko, Arima Hiroshi, Yuzawa Yukio, Minokoshi Yasuhiko, Maruyama Shoichi, Kadomatsu Kenji

    JCI INSIGHT   Vol. 6 ( 20 )   2021.10

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    DOI: 10.1172/jci.insight.142464

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  24. Clinical course of liver injury induced by immune checkpoint inhibitors in patients with advanced malignancies Reviewed International journal

    Ito Takanori, Ishigami Masatoshi, Yamamoto Takafumi, Mizuno Kazuyuki, Yamamoto Kenta, Imai Norihiro, Ishizu Yoji, Honda Takashi, Kawashima Hiroki, Yasuda Satoshi, Toyoda Hidenori, Yokota Kenji, Hase Tetsunari, Nishio Naoki, Maeda Osamu, Kato Masashi, Hashimoto Naozumi, Hibi Hideharu, Kodera Yasuhiro, Sone Michihiko, Ando Yuichi, Akiyama Masashi, Shimoyama Yoshie, Fujishiro Mitsuhiro

    HEPATOLOGY INTERNATIONAL   Vol. 15 ( 5 ) page: 1278 - 1287   2021.10

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    DOI: 10.1007/s12072-021-10238-y

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  25. Factors associated with bleeding after endoscopic variceal ligation in children Reviewed International journal

    Yokoyama Shinya, Ishizu Yoji, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ito Takanori, Hinoki Akinari, Sumida Wataru, Shirota Chiyoe, Tainaka Takahisa, Makita Satoshi, Yokota Kazuki, Uchida Hiroo, Fujishiro Mitsuhiro

    PEDIATRICS INTERNATIONAL   Vol. 63 ( 10 ) page: 1223 - 1229   2021.10

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    DOI: 10.1111/ped.14614

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  26. Differentiation between pancreatic metastases from renal cell carcinoma and pancreatic neuroendocrine neoplasm using endoscopic ultrasound. Reviewed International journal

    Kataoka K, Ishikawa T, Ohno E, Mizutani Y, Iida T, Ishikawa E, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 21 ( 7 ) page: 1364 - 1370   2021.10

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    DOI: 10.1016/j.pan.2021.07.001

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  27. Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis Reviewed International journal

    Muto Hisanori, Ito Takanori, Tanaka Taku, Yokoyama Shinya, Yamamoto Kenta, Imai Norihiro, Ishizu Yoji, Maeda Keiko, Honda Takashi, Ishikawa Tetsuya, Kato Asuka, Ohshiro Taichi, Kano Fumiya, Yamamoto Akihito, Sakai Kiyoshi, Hibi Hideharu, Ishigami Masatoshi, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 18778   2021.9

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    DOI: 10.1038/s41598-021-98254-8

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  28. Revisiting Prognosis After Liver Transplant in Patients Positive for Hepatitis C Virus: Focus on Hepatitis C Recurrence-Unrelated Complications Reviewed International journal

    Ishigami Masatoshi, Honda Takashi, Ishizu Yoji, Imai Norihiro, Ito Takanori, Yamamoto Kenta, Kamei Hideya, Ogura Yasuhiro, Fujishiro Mitsuhiro

    EXPERIMENTAL AND CLINICAL TRANSPLANTATION   Vol. 19 ( 9 ) page: 935 - 942   2021.9

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    DOI: 10.6002/ect.2021.0197

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  29. Transient deterioration of albumin-bilirubin scores in early post-dose period of molecular targeted therapies in advanced hepatocellular carcinoma with 50% or higher liver occupation A STROBE-compliant retrospective observational study Reviewed International journal

    Muto Hisanori, Kuzuya Teiji, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Ishigami Masatoshi, Fujishiro Mitsuhiro

    MEDICINE   Vol. 100 ( 31 ) page: e26820   2021.8

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    DOI: 10.1097/MD.0000000000026820

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  30. Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective study Reviewed International journal

    Otsuka Hiroyuki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawade Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Iliroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 3 ) page: 419 - 430   2021.8

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    DOI: 10.18999/nagjms.83.3.419

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  31. Fecal incontinence and oral regurgitation during duodenal endoscopic submucosal dissection using the water pressure method Reviewed International journal

    Takada Yoshihisa, Hirose Takashi, Nishida Kazuki, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY     2021.7

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    DOI: 10.1111/den.14070

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  32. Endoscopic papillectomy for ampullary adenoma and early adenocarcinoma: Analysis of factors related to treatment outcome and long-term prognosis. Reviewed International journal

    Kawashima H, Ohno E, Ishikawa T, Iida T, Tanaka H, Furukawa K, Nakamura M, Honda T, Hashimoto S, Itoh A, Ishigami M, Hirooka Y, Fujishiro M

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 33 ( 5 ) page: 858 - 869   2021.7

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    DOI: 10.1111/den.13881

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  33. Lewis score on capsule endoscopy can predict the prognosis in patients with small bowel lesions of Crohn's disease. Reviewed International journal

    Nishikawa T, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M

    Journal of gastroenterology and hepatology   Vol. 36 ( 7 ) page: 1851 - 1858   2021.7

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    DOI: 10.1111/jgh.15366

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  34. An initial trial of quantitative evaluation of autoimmune pancreatitis using shear wave elastography and shear wave dispersion in transabdominal ultrasound. Reviewed International journal

    Suzuki H, Ishikawa T, Ohno E, Iida T, Uetsuki K, Yashika J, Yamada K, Yoshikawa M, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 21 ( 4 ) page: 682 - 687   2021.6

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    DOI: 10.1016/j.pan.2021.02.014

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  35. Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis Reviewed International journal

    Tanaka Hiroyuki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Ishikawa Eri, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Shimoyama Yoshie, Miyahara Ryoji, Kawabe Naoto, Kuzuya Teiji, Hashimoto Senju, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   Vol. 21 ( 1 ) page: 224   2021.5

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    DOI: 10.1186/s12876-021-01811-8

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  36. Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency Reviewed International journal

    Uetsuki Kota, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Yamamoto Kenta, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   Vol. 21 ( 1 ) page: 211   2021.5

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    DOI: 10.1186/s12876-021-01776-8

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  37. Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs Reviewed International journal

    Yamamoto Takafumi, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    ANTICANCER RESEARCH   Vol. 41 ( 5 ) page: 2569 - 2573   2021.5

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    DOI: 10.21873/anticanres.15035

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  38. Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer Reviewed International journal

    Yoshikawa Masakatsu, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kinoshita Fumie, Kawashima Hiroki, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 7409   2021.4

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    DOI: 10.1038/s41598-021-86979-5

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  39. Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice. Reviewed International journal

    Nishikawa T, Maeda K, Nakamura M, Yamamura T, Sawada T, Mizutani Y, Ito T, Ishikawa T, Furukawa K, Ohno E, Miyahara R, Kawashima H, Honda T, Ishigami M, Yamamoto T, Matsumoto S, Hotta Y, Fujishiro M

    Digestive diseases and sciences   Vol. 66 ( 4 ) page: 1034 - 1044   2021.4

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    DOI: 10.1007/s10620-020-06359-3

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  40. Impact of visceral fat accumulation on the prognosis of patients with cirrhosis Reviewed International journal

    Ishizu Yoji, Ishigami Masatoshi, Honda Takashi, Imai Norihiro, Ito Takanori, Yamamoto Kenta, Fujishiro Mitsuhiro

    CLINICAL NUTRITION ESPEN   Vol. 42   page: 354 - 360   2021.4

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    DOI: 10.1016/j.clnesp.2021.01.008

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  41. Quality of Life in patients with nonalcoholic fatty liver disease: Structure and related factors focusing on illness uncertainty Reviewed International journal

    Ozawa Naoki, Sato Kazuki, Sugimura Ayumi, Maki Shigeyoshi, Tanaka Taku, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro, Ishikawa Tetsuya, Ando Shoko

    JAPAN JOURNAL OF NURSING SCIENCE   Vol. 18 ( 3 ) page: e12415   2021.3

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  42. Simplification of balloon-occluded retrograde transcatheter obliteration procedure using a coaxial double balloon catheter compared with a single-balloon catheter. Reviewed International journal

    Ishizu Y, Ishigami M, Honda T, Kuzuya T, Ito T, Komada T, Fujishiro M

    Japanese journal of radiology   Vol. 39 ( 3 ) page: 296 - 302   2021.3

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    DOI: 10.1007/s11604-020-01060-x

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  43. Endoscopic ultrasound elastography for small solid pancreatic lesions with or without main pancreatic duct dilatation. Reviewed International journal

    Kataoka K, Ishikawa T, Ohno E, Iida T, Suzuki H, Uetsuki K, Furukawa K, Nakamura M, Honda T, Ishigami M, Kawashima H, Hirooka Y, Fujishiro M

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 21 ( 2 ) page: 451 - 458   2021.3

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  44. Progression After Molecular Targeted Agents: Hepatic Arterial Changes and Transarterial Chemoembolization in Hepatocellular Carcinoma. Reviewed International journal

    Matsuda N, Imai N, Kuzuya T, Yamamoto K, Ito T, Ishizu Y, Honda T, Ishigami M, Fujishiro M

    In vivo (Athens, Greece)   Vol. 35 ( 2 ) page: 1185 - 1189   2021.3

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  45. Utility of multiphase contrast enhancement patterns on CEH-EUS for the differential diagnosis of IPMN-derived and conventional pancreatic cancer. Reviewed International journal

    Yashika J, Ohno E, Ishikawa T, Iida T, Suzuki H, Uetsuki K, Yamada K, Yoshikawa M, Gibo N, Shimoyama Y, Ishikawa E, Furukawa K, Nakamura M, Honda T, Ishigami M, Hirooka Y, Kawashima H, Fujishiro M

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   Vol. 21 ( 2 ) page: 390 - 396   2021.3

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  46. Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract Reviewed International journal

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   Vol. 21 ( 1 ) page: 75   2021.2

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  47. Ustekinumab is effective against small bowel lesions in Crohn's disease: two case reports. Reviewed International journal

    Murate K, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M

    Clinical journal of gastroenterology   Vol. 14 ( 1 ) page: 129 - 135   2021.2

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  48. Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma patients with haemophilia Reviewed International journal

    Yamamoto Takafumi, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    HAEMOPHILIA   Vol. 27 ( 1 ) page: 100 - 107   2021.1

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  49. Systematic review and meta-analysis of the diagnostic and therapeutic yield of small bowel endoscopy in patients with overt small bowel bleeding. Reviewed International journal

    Uchida G, Nakamura M, Yamamura T, Furukawa K, Kawashima H, Honda T, Ishigami M, Fujishiro M

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 33 ( 1 ) page: 66 - 82   2021.1

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    DOI: 10.1111/den.13669

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  50. Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy. Reviewed International journal

    Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa E, Kakushima N, Furukawa K, Ishikawa T, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M

    Canadian journal of gastroenterology & hepatology   Vol. 2021   page: 8875564   2021

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  51. Increased Frequency of Dysfunctional Siglec-7<sup>-</sup>CD57<sup>+</sup>PD-1<sup>+</sup> Natural Killer Cells in Patients With Non-alcoholic Fatty Liver Disease. Reviewed International journal

    Sakamoto Y, Yoshio S, Doi H, Mori T, Matsuda M, Kawai H, Shimagaki T, Yoshikawa S, Aoki Y, Osawa Y, Yoshida Y, Arai T, Itokawa N, Atsukawa M, Ito T, Honda T, Mise Y, Ono Y, Takahashi Y, Saiura A, Taketomi A, Kanto T

    Frontiers in immunology   Vol. 12   page: 603133   2021

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  52. SYSTEMATIC REVIEW AND META-ANALYSIS OF THE DIAGNOSTIC AND THERAPEUTIC YIELD OF SMALL BOWEL ENDOSCOPY IN PATIENTS WITH OVERT SMALL BOWEL BLEEDING Reviewed

    UCHIDA Genta, NAKAMURA Masanao, YAMAMURA Takeshi, FURUKAWA Kazuhiro, KAWASHIMA Hiroki, HONDA Takashi, ISHIGAMI Masatoshi, FUJISHIRO Mitsuhiro

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 63 ( 9 ) page: 1649 - 1665   2021

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    <p>Background: Small bowel endoscopy, including small bowel capsule endoscopy (SBCE) and balloon-assisted endoscopy (BAE), is useful for small bowel bleeding (SBB) assessment. However, the specific management strategy for overt SBB is not well established. This meta-analysis aimed to evaluate the pooled diagnostic yields (DYs) and therapeutic yields (TYs) of small bowel endoscopy in overt SBB and to determine the optimal endoscopy timing.</p><p>Methods: A comprehensive literature search was performed of studies examining the DY and/or TY of small bowel endoscopy in overt SBB. Data on the DY, TY, and timing of small bowel endoscopy were extracted, pooled, and analyzed. The pooled DY and TY of small bowel endoscopy for patients with overt SBB were calculated. Meta-regression and subgroup analysis were performed.</p><p>Results: Twenty-two studies were included. The pooled DY was 65.2% and 74.0% for SBCE and BAE, respectively. The pooled TY of SBCE and BAE was 55.9% and 35.8%, respectively. A meta-regression model showed that the timing of endoscopy was significantly associated with the DY of BAE and the TY of SBCE and BAE.</p><p>Conclusions: Small bowel capsule endoscopy and BAE would be useful diagnostic and therapeutic modalities in overt SBB. According to the subgroup analysis, in which the TY seemed to be higher within 2 days after bleeding for SBCE and BAE, the optimal timing of endoscopy would be within 2 days.</p>

    DOI: 10.11280/gee.63.1649

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  53. Feasibility and usefulness of endoscopic ultrasonography-guided shear-wave measurement for assessment of autoimmune pancreatitis activity: a prospective exploratory study Reviewed

    OHNO Eizaburo, HONDA Takashi, HIROOKA Yoshiki, KAWASHIMA Hiroki, ISHIKAWA Takuya, TANAKA Hiroyuki, SAKAI Daisuke, ISHIZU Yoji, KUZUYA Teiji, NAKAMURA Masanao

    Choonpa Igaku   Vol. 48 ( 1 ) page: 35 - 44   2021

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    <p><b>Purpose</b>: To assess the feasibility and the clinical usefulness of a newly developed endoscopic ultrasonography (EUS) shearwave elastography technique (EUS shear-wave measurement: EUS-SWM) in the diagnosis and treatment of autoimmune pancreatitis (AIP). <b>Methods</b>: Tissue elasticity was measured in the pancreas in 160 patients. The success rate of EUS-SWMs, the velocity of the shear wave (Vs, m/s), and the reliability index of the Vs measurement (VsN) were evaluated, and the elasticity (median Vs) was compared between AIP patients (<I>n</I>=14) and normal controls. <b>Results</b>: A total of 3837 EUS-SWMs were performed without adverse events. Overall, 97.6% (3,743/3,837) were successful. The median VsN was 74%. The median Vs values of the pancreas were as follows: 2.22 m/s in the pancreatic head (push position), 2.36 m/s in the head (pull position), 1.99 m/s in the body, and 2.25 m/s in the tail. The median Vs of the AIP group (2.57 m/s) was significantly higher than that of the normal controls (1.89 m/s) (<I>P</I>=0.0185). The mean Vs significantly decreased from 3.32 m/s to 2.46 m/s after steroid therapy (<I>n</I>=6) (<I>P</I>=0.0234). <b>Conclusion</b>: EUS-SWM is feasible and generates credible results. EUS-SWM was a useful method for assessment of the effect of steroid therapy in AIP patients.</p>

    DOI: 10.3179/jjmu.JJMU.K.22

  54. *The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease. Reviewed International journal

    Hattori S, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Yamamoto K, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Hirooka Y, Fujishiro M

      Vol. 55 ( 12 ) page: 1138 - 1149   2020.12

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  55. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy Reviewed International journal

    Niwa Yoshiki, Nakamura Masanao, Kawashima Hiroki, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   Vol. 26 ( 42 ) page: 6669 - 6678   2020.11

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    DOI: 10.3748/wjg.v26.i42.6669

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  56. Endoscopic Activity and Serum TNF-alpha Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients Reviewed International journal

    Murate Kentaro, Maeda Keiko, Nakamura Masanao, Sugiyama Daisuke, Wada Hirotaka, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Miyahara Ryoji, Ishigami Masatoshi, Nishikawa Hiroyoshi, Fujishiro Mitsuhiro

    INFLAMMATORY BOWEL DISEASES   Vol. 26 ( 11 ) page: 1669 - 1681   2020.11

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  57. The albumin-bilirubin score as a predictor of outcomes in Japanese patients with PBC: an analysis using time-dependent ROC Reviewed International journal

    Ito Takanori, Ishigami Masatoshi, Morooka Hikaru, Yamamoto Kenta, Imai Norihiro, Ishizu Yoji, Honda Takashi, Nishimura Daisaku, Tada Toshifumi, Yasuda Satoshi, Toyoda Hidenori, Kumada Takashi, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 17812   2020.10

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    DOI: 10.1038/s41598-020-74732-3

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  58. Revisiting the indications for liver transplantation in cirrhotic patients considering the long-term outcomes of cirrhotic patients. Reviewed International journal

    Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Kamei H, Ogura Y, Fujishiro M

    Journal of hepato-biliary-pancreatic sciences   Vol. 27 ( 9 ) page: 655 - 662   2020.9

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    DOI: 10.1002/jhbp.777

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  59. Limitation of non-transplant treatment and proper timing for liver transplantation in patients with hepatocellular carcinoma considering long-term survival. Reviewed International journal

    Nomura A, Ishigami M, Honda T, Kuzuya T, Ishizu Y, Ito T, Kamei H, Onishi Y, Ogura Y, Fujishiro M

    Medicine   Vol. 99 ( 28 ) page: e21161   2020.7

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    DOI: 10.1097/MD.0000000000021161

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  60. Complete response of advanced hepatocellular carcinoma achieved by sorafenib dose re-escalation after failure of long-term low-dose-sorafenib treatment combined with transcatheter arterial chemoembolization: a case report. Reviewed International journal

    Muto H, Kuzuya T, Ito T, Ishizu Y, Honda T, Ishikawa T, Ishigami M, Fujishiro M

    Clinical journal of gastroenterology   Vol. 13 ( 3 ) page: 397 - 402   2020.6

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    DOI: 10.1007/s12328-019-01066-7

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  61. Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies Reviewed International journal

    Mizuno Kazuyuki, Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Kawashima Hiroki, Inukai Yosuke, Toyoda Hidenori, Yokota Kenji, Hase Tetsunari, Maeda Osamu, Kiyoi Hitoshi, Nagino Masato, Hibi Hideharu, Kodera Yasuhiro, Fujimoto Yasushi, Sone Michihiko, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY   Vol. 55 ( 6 ) page: 653 - 661   2020.6

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    DOI: 10.1007/s00535-020-01677-9

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  62. Correlation of serum zinc levels with pathological and laboratory findings in patients with nonalcoholic fatty liver disease Reviewed International journal

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishikawa Tetsuya, Toyoda Hidenori, Kumada Takashi, Fujishiro Mitsuhiro

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   Vol. 32 ( 6 ) page: 748 - 753   2020.6

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    DOI: 10.1097/MEG.0000000000001587

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  63. Nonexposed wall-inversion surgery as a novel local resection method for neoplasms in the gastrointestinal tract. Reviewed International journal

    Fujishiro M, Furukawa K, Yamamura T, Nakamura M, Honda T, Maeda O, Ishigami M, Kawashima H

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 175 - 182   2020.5

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    DOI: 10.18999/nagjms.82.2.175

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  64. Sorafenib <i>vs</i>. Lenvatinib as First-line Therapy for Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis. Reviewed International journal

    Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M

    Anticancer research   Vol. 40 ( 4 ) page: 2283 - 2290   2020.4

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    DOI: 10.21873/anticanres.14193

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  65. Initial Experience of Ramucirumab Treatment After Lenvatinib Failure for Patients With Advanced Hepatocellular Carcinoma. Reviewed International journal

    Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M

    Anticancer research   Vol. 40 ( 4 ) page: 2089 - 2093   2020.4

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    DOI: 10.21873/anticanres.14167

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  66. Favorable radiological antitumor response at 2 weeks after starting lenvatinib for patients with advanced hepatocellular carcinoma Reviewed International journal

    Kuzuya Teiji, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Fujishiro Mitsuhiro

    HEPATOLOGY RESEARCH   Vol. 50 ( 3 ) page: 374 - 381   2020.3

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    DOI: 10.1111/hepr.13452

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  67. *Microbiota profile is different for early and invasive colorectal cancer and is consistent throughout the colon. Reviewed International coauthorship International journal

    Zorron Cheng Tao Pu L, Yamamoto K, Honda T, Nakamura M, Yamamura T, Hattori S, Burt AD, Singh R, Hirooka Y, Fujishiro M

    Journal of gastroenterology and hepatology   Vol. 35 ( 3 ) page: 433 - 437   2020.3

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  68. Relationship Between Adverse Events and Microbiomes in Advanced Hepatocellular Carcinoma Patients Treated With Sorafenib. Reviewed International journal

    Yamamoto K, Kuzuya T, Honda T*, Ito T, Ishizu Y, Nakamura M, Miyahara R, Kawashima H, Ishigami M, Fujishiro M

    Anticancer research   Vol. 40 ( 2 ) page: 665 - 676   2020.2

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    DOI: 10.21873/anticanres.13996

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  69. Effect of weight change and lifestyle modifications on the development or remission of nonalcoholic fatty liver disease: sex-specific analysis. Reviewed International journal

    Yoshioka N, Ishigami M, Watanabe Y, Sumi H, Doisaki M, Yamaguchi T, Ito T, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Haruta JI, Fujishiro M

    Scientific reports   Vol. 10 ( 1 ) page: 481   2020.1

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    DOI: 10.1038/s41598-019-57369-9

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  70. Development of a novel anti-hepatitis B virus agent via Sp1 Reviewed International journal

    Hayakawa Michiyo, Umeyama Hideaki, Iwadate Mitsuo, Taguchi Y. -H., Yano Yoshihiko, Honda Takashi, Itami-Matsumoto Saori, Kozuka Ritsuzo, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Murakami Yoshiki

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 47   2020.1

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    DOI: 10.1038/s41598-019-56842-9

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  71. Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection Reviewed International journal

    Ishizu Yoji, Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Kuzuya Teiji, Ito Takanori, Fujishiro Mitsuhiro

    HEPATOLOGY RESEARCH   Vol. 50 ( 1 ) page: 47 - 56   2020.1

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    DOI: 10.1111/hepr.13426

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  72. Serum Nutritional Markers as Prognostic Factors for Hepatic and Extrahepatic Carcinogenesis in Japanese Patients with Nonalcoholic Fatty Liver Disease. Reviewed International journal

    Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Toyoda H, Kumada T, Fujishiro M

    Nutrition and cancer   Vol. 72 ( 5 ) page: 884 - 891   2020

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    DOI: 10.1080/01635581.2019.1653474

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  73. Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis Reviewed International journal

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ohashi Ayako, Kajikawa Go, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    INTERNAL MEDICINE   Vol. 59 ( 23 ) page: 3009 - 3014   2020

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    DOI: 10.2169/internalmedicine.5302-20

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  74. Efficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion. Reviewed International journal

    Tanaka T, Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Fujishiro M

    Oncology   Vol. 98 ( 9 ) page: 621 - 629   2020

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    DOI: 10.1159/000507051

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  75. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope. Reviewed International journal

    Suzuki H, Nakamura M, Yamamura T, Maeda K, Sawada T, Mizutani Y, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Fujishiro M

    Internal medicine (Tokyo, Japan)   Vol. 59 ( 15 ) page: 1795 - 1801   2020

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    DOI: 10.2169/internalmedicine.4267-19

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  76. Sarcopenia impairs health-related quality of life in cirrhotic patients. Reviewed International journal

    Ando Y, Ishigami M, Ito T, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Fujishiro M

    European journal of gastroenterology & hepatology   Vol. 31 ( 12 ) page: 1550 - 1556   2019.12

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    DOI: 10.1097/MEG.0000000000001472

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  77. Spleen stiffness by 2-D shear wave elastography is the most accurate predictor of high-risk esophagogastric varices in children with biliary atresia Reviewed International journal

    Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Hirooka Yoshiki, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Chiba Kosuke, Uchida Hiroo, Fujishiro Mitsuhiro

    HEPATOLOGY RESEARCH   Vol. 49 ( 10 ) page: 1162 - 1168   2019.10

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    DOI: 10.1111/hepr.13381

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  78. Feasibility and usefulness of endoscopic ultrasonography-guided shear-wave measurement for assessment of autoimmune pancreatitis activity: a prospective exploratory study. Reviewed International journal

    Ohno E, Hirooka Y, Kawashima H, Ishikawa T, Tanaka H, Sakai D, Ishizu Y, Kuzuya T, Nakamura M, Honda T

    Journal of medical ultrasonics (2001)   Vol. 46 ( 4 ) page: 425 - 433   2019.10

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    DOI: 10.1007/s10396-019-00944-4

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  79. Antifibrotic Effects of 1,25(OH)2D3 on Nonalcoholic Steatohepatitis in Female Mice. Reviewed International journal

    Ma L, Ishigami M, Honda T, Yokoyama S, Yamamoto K, Ishizu Y, Kuzuya T, Hayashi K, Hirooka Y, Goto H.

    Digestive diseases and sciences   Vol. 64 ( 9 ) page: 2581 - 2590   2019.9

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    DOI: 10.1007/s10620-019-05560-3

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  80. Clinical characteristics and outcomes of candidates for second-line therapy, including regorafenib and ramucirumab, for advanced hepatocellular carcinoma after sorafenib treatment. Reviewed International journal

    Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Ishikawa T, Hirooka Y, Fujishiro M

    Hepatology research : the official journal of the Japan Society of Hepatology   Vol. 49 ( 9 ) page: 1054 - 1065   2019.9

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    DOI: 10.1111/hepr.13358

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  81. *Influence of proton pump inhibitors on microbiota in chronic liver disease patients Reviewed International journal

    Yamamoto K, Ishigami M, Honda T, Takeyama T, Ito T, Ishizu Y, Kuzuya T, Hayashi K, Goto H, Hirooka Y.

    Hepatology International   Vol. 13 ( 2 ) page: 234-244   2019.3

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  82. Complete response by vitamin K2 analog monotherapy in sorafenib-failure advanced hepatocellular carcinoma: A case report. Reviewed International journal

    Kuzuya T, Ishigami M, Ishizu Y, Honda T, Hayashi K, Ishikawa T, Hirooka Y, Goto H.

    Hepatol Res.   Vol. 49 ( 3 ) page: 360-364   2019.3

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  83. Successful treatment of esophageal bleeding due to rupture of major aortopulmonary collateral arteries by transcatheter arterial embolization. Reviewed International journal

    Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Matsushima M, Kato T, Hirooka Y

    Clinical journal of gastroenterology   Vol. 12 ( 1 ) page: 20 - 24   2019.2

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    DOI: 10.1007/s12328-018-0895-8

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  84. Utility and limitations of noninvasive fibrosis markers for predicting prognosis in biopsy-proven Japanese non-alcoholic fatty liver disease patients. Reviewed International journal

    Ito T, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, Nishimura D, Toyoda H, Kumada T, Goto H, Hirooka Y

    Journal of gastroenterology and hepatology   Vol. 34 ( 1 ) page: 207 - 214   2019.1

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    DOI: 10.1111/jgh.14448

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  85. The Prevalence of Mixed Hepatitis C Virus Genotype Infection and Its Effect on the Response to Direct-Acting Antivirals Therapy. Reviewed International journal

    Hayashi K, Tachi K, Shimizu Y, Nagano K, Ishizu Y, Kuzuya T, Honda T, Ishigami M, Hirooka Y, Hattori M, Goto H

    Intervirology   Vol. 62 ( 1 ) page: 23 - 29   2019

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    DOI: 10.1159/000499691

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  86. Successful Treatment of Hepatocellular Carcinoma with Regorafenib after Sorafenib-induced Hypersensitivity Reviewed International journal

    Yoshioka Naoki, Kuzuya Teiji, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Ishigami Masatoshi, Fujishiro Mitsuhiro

    INTERNAL MEDICINE   Vol. 58 ( 19 ) page: 2803 - 2808   2019

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    DOI: 10.2169/internalmedicine.2812-19

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  87. Late relapse of hepatitis C virus in patients with sustained virological response after daclatasvir and asunaprevir therapy. Reviewed International journal

    Hayashi K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hirooka Y, Toyoda H, Kumada T, Hattori M, Katano Y, Goto H.

    J Viral Hepat.   Vol. 25 ( 12 ) page: 1446 - 1451   2018.12

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  88. Utility of contrast-enhanced ultrasonography with perflubutane in evaluating indications for diagnostic percutaneous tumor biopsy in a case of hepatic sclerosed hemangioma. Reviewed International journal

    Ando Y, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hirooka Y

    Clinical journal of gastroenterology   Vol. 11 ( 6 ) page: 514 - 520   2018.12

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    DOI: 10.1007/s12328-018-0880-2

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  89. Substitutions in interferon sensitivity-determining region and hepatocarcinogenesis after hepatitis C virus eradication. Reviewed International journal

    Yasuda S, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, Toyoda H, Kumada T, Hirooka Y, Goto H.

    J Gastroenterol Hepatol   Vol. 33 ( 11 ) page: 1904-1911   2018.11

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  90. Skeletal muscle fat deposition is associated with hepatocellular carcinoma development in patients with chronic liver disease. Reviewed International journal

    Tachi Y, Kozuka A, Hirai T, Kojima Y, Ishizu Y, Honda T, Kuzuya T, Hayashi K, Ishigami M, Goto H.

    Nutrition   Vol. 54   page: 83-88   2018.10

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  91. Predictive ability of shear wave elastography for pruritus in chronic hepatitis C patients with sustained virological response. Reviewed International journal

    Tachi Y, Hirai T, Kojima Y, Ishizu Y, Honda T, Kuzuya T, Hayashi K, Ishigami M, Goto H, Katano Y.

    Eur J Gastroenterol Hepatol.   Vol. 30 ( 9 ) page: 1066-1072   2018.9

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  92. Daclatasvir and asunaprevir treatment in patients infected by genotype 1b of hepatitis C virus with no or subtle resistant associated substitutions (RAS) in NS5A-Y93 Reviewed International journal

    Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ishikawa Tetsuya, Nakano Isao, Urano Fumihiro, Kumada Takashi, Yoshioka Kentaro, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF MEDICAL VIROLOGY   Vol. 90 ( 4 ) page: 736 - 744   2018.4

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    DOI: 10.1002/jmv.24978

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  93. Impact of myosteatosis on skeletal muscle volume loss in patients with chronic liver disease. Reviewed International journal

    Tachi Y, Kozuka A, Hirai T, Ishizu Y, Honda T, Kuzuya T, Hayashi K, Ishigami M, Goto H.

    J Gastroenterol Hepatol     2018.2

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    DOI: 10.1111/jgh.14133

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  94. Occurrence of late relapse of hepatitis C virus confirmed by molecular analysis after sustained virologic response to interferon-ribavirin-based therapy Reviewed International journal

    Hayashi Kazuhiko, Ishigami Masatoshi, Yasuda Satoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishikawa Tetsuya, Hirooka Yoshiki, Goto Hidemi

    HEPATOLOGY RESEARCH   Vol. 48 ( 3 ) page: E78 - E86   2018.2

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    DOI: 10.1111/hepr.12929

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  95. Prognostic Factors Associated with Postprogression Survival in Advanced Hepatocellular Carcinoma Patients Treated with Sorafenib Not Eligible for Second-Line Regorafenib Treatment. Reviewed International journal

    Kuzuya T, Ishigami M, Ishizu Y, Honda T, Hayashi K, Ishikawa T, Nakano I, Hirooka Y, Goto H

    Oncology   Vol. 95 ( 2 ) page: 91 - 99   2018

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    DOI: 10.1159/000488453

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  96. Liver stiffness measurement predicts hepatocellular carcinoma development in patients treated with direct-acting antivirals. Reviewed International journal

    Tachi Y, Hirai T, Kojima Y, Ishizu Y, Honda T, Kuzuya T, Hayashi K, Ishigami M, Goto H

    JGH open : an open access journal of gastroenterology and hepatology   Vol. 1 ( 1 ) page: 44 - 49   2017.9

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    DOI: 10.1002/jgh3.12007

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  97. Utility of Doppler ultrasonography for diagnosing and assessing treatment effects in liver compartment syndrome Reviewed International journal

    Ando Yusuke, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Ishikawa Tetsuya, Goto Hidemi, Hirooka Yoshiki

    CLINICAL JOURNAL OF GASTROENTEROLOGY   Vol. 10 ( 3 ) page: 265 - 269   2017.6

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    DOI: 10.1007/s12328-017-0741-4

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  98. Real World Data of Daclatasvir and Asunaprevir Combination Therapy for HCV Genotype 1b Infection in Patients With Renal Dysfunction Reviewed International journal

    Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ishikawa Tetsuya, Nakano Isao, Urano Fumihiro, Kumada Takashi, Yoshioka Kentaro, Goto Hidemi, Hirooka Yoshiki

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   Vol. 15 ( 5 ) page: 787 - 788   2017.5

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    DOI: 10.1016/j.cgh.2016.12.009

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  99. Liver fibrosis indices for identifying patients at low risk of developing hepatocellular carcinoma after eradication of HCV. Reviewed International journal

    Toyoda H, Tada T, Tachi Y, Hirai T, Yasuda S, Honda T, Hayashi K, Ishigami M, Goto H, Kumada T.

    Antivir Ther.   Vol. 22 ( 3 ) page: 185 - 193   2017

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    DOI: 10.3851/IMP3081

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  100. Daclatasvir and asunaprevir treatment in patients with severe liver fibrosis by HCV genotype 1b infection: Real world data. Reviewed International journal

    Ishigami M, Hayashi K, Honda T, Kuzuya T, Ishizu Y, Ishikawa T, Nakano I, Urano F, Kumada T, Yoshioka K, Goto H, Hirooka Y.

    J Gastroenterol Hepatol   Vol. 32 ( 11 ) page: 1879-1886   2017

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  101. Low skeletal muscle mass predicts early mortality in cirrhotic patients with acute variceal bleeding. Reviewed International journal

    Ishizu Y, Ishigami M, Kuzuya T, Honda T, Hayashi K, Ishikawa T, Hirooka Y, Goto H.

    Nutrition.   Vol. 42   page: 87-91   2017

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  102. Cumulative incidence and risk factors for the development of hepatocellular carcinoma in patients with chronic hepatitis B who achieved sustained disappearance of viremia by nucleos(t)ide analog treatment. Reviewed International journal

    Ando Y, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, Ishikawa T, Nakano I, Hirooka Y, Goto H.

    Hepatol Res     2017

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    DOI: 10.1111/hepr.12976.

  103. Occurrence of late relapse of hepatitis C virus confirmed by molecular analysis after sustained virologic response to interferon-ribavirin-based therapy. Reviewed International journal

    Hayashi K, Ishigami M, Yasuda S, Ishizu Y, Kuzuya T, Honda T, Ishikawa T, Hirooka Y, Goto H.

    Hepatol Res     2017

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    DOI: 10.1111/hepr.12929.

  104. Liver stiffness reduction correlates with histological characteristics of Hepatitis C patients with sustained virological response Reviewed International journal

    Tachi Y, Hirai T, Kojima Y, Ishizu Y, Honda T, Kuzuya T, Hayashi K, Ishigami M, Goto H.

    Liver Int.   Vol. 38 ( 1 ) page: 59 - 67   2017

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    DOI: 10.1111/liv.13486.

  105. A comparison of direct sequencing and Invader assay for Y93H mutation and response to interferon-free therapy in hepatitis C virus genotype 1b Reviewed International journal

    Hayashi K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Kawashima H, Ishikawa T, Tachi Y, Hattori M, Katano Y, Goto H, Hirooka Y.

    J Gastroenterol Hepatol     2017

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    DOI: 10.1111/jgh.13809.

  106. Hepatocyte-Specific Depletion of Ubiquitin Regulatory X Domain Containing Protein 8 Accelerates Fibrosis in a Mouse Non-Alcoholic Steatohepatitis Model Reviewed International journal

    Imai N, Suzuki M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, Ishigami M, Hirooka Y, Ishikawa T, Goto H, Fujimoto T.

    Histochemistry and Cell Biology   Vol. 183 ( 3 ) page: 219-227   2017

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  107. *Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. Reviewed International journal

    Honda T, Ishigami M, Luo F, Lingyun M, Ishizu Y, Kuzuya T, Hayashi K, Nakano I, Ishikawa T, Feng GG, Katano Y, Kohama T, Kitaura Y, Shimomura Y, Goto H, Hirooka Y.

    Metabolism.   Vol. 69   page: 177-187   2017

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  108. *The Core I97L mutation in conjunction with P79Q is associated with persistent low HBVDNA and HBs antigen clearance in chronic hepatitis B patients Reviewed International journal

    Honda T, Ishigami M, Ishizu Y1, Kuzuya T, Hayashi K, Ishikawa T, Murakami Y, Iwadate M, Umeyama H, Toyoda H, Kumada T, Katano Y, Goto H, Hirooka Y.

    Clin Microbiol Infect.   Vol. 23 ( 407 ) page: e1-e7   2016.12

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  109. Clinical characteristics and molecular analysis of hepatitis B virus reactivation in hepatitis B surface antigen-negative patients during or after immunosuppressive or cytotoxic chemotherapy Reviewed International journal

    Hayashi Kazuhiko, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Tachi Yoshihiko, Ishikawa Tetsuya, Katano Yoshiaki, Yoshioka Kentaro, Toyoda Hidenori, Kumada Takashi, Goto Hidemi, Hirooka Yoshiki

    JOURNAL OF GASTROENTEROLOGY   Vol. 51 ( 11 ) page: 1081 - 1089   2016.11

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    DOI: 10.1007/s00535-016-1187-z

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  110. Fever within 2 Weeks of Sorafenib Therapy Predicts Favorable Treatment Efficacy in Patients with Advanced Hepatocellular Carcinoma. Reviewed International journal

    Kuzuya T, Ishigami M, Ishizu Y, Honda T, Hayashi K, Ishikawa T, Nakano I, Goto H, Hirooka Y.

    Oncology.   Vol. 91 ( 5 ) page: 261-266   2016.9

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  111. A case of acute hepatitis B in a chronic hepatitis C patient after daclatasvir and asunaprevir combination therapy: hepatitis B virus reactivation or acute self-limited hepatitis? Reviewed International journal

    Hayashi Kazuhiko, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Nishimura Daisaku, Goto Hidemi, Hirooka Yoshiki

    CLINICAL JOURNAL OF GASTROENTEROLOGY   Vol. 9 ( 4 ) page: 252 - 256   2016.8

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    DOI: 10.1007/s12328-016-0657-4

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  112. Liver stiffness measurement using acoustic radiation force impulse elastography in hepatitis C virus-infected patients with a sustained virological response. Reviewed International journal

    Tachi Y, Hirai T, Kojima Y, Miyata A, Ohara K, Ishizu Y, Honda T, Kuzuya T, Hayashi K, Ishigami M, Goto H.

    Alimentary Pharmacology Therapeutics   Vol. 44 ( 4 ) page: 346-55   2016.6

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  113. Clinical characteristics and molecular analysis of hepatitis B virus reactivation in hepatitis B surface antigen-negative patients during or after immunosuppressive or cytotoxic chemotherapy. Reviewed International journal

    Hayashi K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Tachi Y, Ishikawa T, Katano Y, Yoshioka K, Toyoda H, Kumada T, Goto H, Hirooka Y.

    J Gastroenterol.   Vol. 51 ( 11 ) page: 1081-1089   2016.3

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  114. *DSS colitis promotes tumorigenesis and fibrogenesis in a choline-deficient high-fat diet-induced NASH mouse model. Reviewed International journal

    Achiwa K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, Hirooka Y, Katano Y, Goto H.

    Biochem Biophys Res Commun   Vol. 470 ( 1 ) page: 15 - 21   2016.1

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  115. α-fetoprotein levels after interferon therapy predict regression of liver fibrosis in patients with sustained virological response Reviewed International journal

    Tachi Y, Hirai T, Ishizu Y, Honda T, Kuzuya T, Hayashi K, Ishigami M, Goto H.

    J Gastroenterol Hepatol   Vol. 31 ( 5 ) page: 1001 - 1008   2016

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    DOI: 10.1111/jgh.13245.

  116. Real world data of daclatasvir and asunaprevir combination therapy for HCV genotype 1b infection in patients with renal dysfunction Reviewed International journal

    Ishigami M, Hayashi K, Honda T, Kuzuya T, Ishizu Y, Ishikawa T, Nakano I, Urano F, Kumada T, Yoshioka K, Goto H, Hirooka Y.

    Clin Gastroenterol Hepatol.   Vol. 15 ( 5 ) page: 787-788   2016

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  117. Immunoglobulin G4-associated autoimmune hepatitis later complicated by autoimmune pancreatitis: A case report. Reviewed International journal

    Ishizu Y, Ishigami M, Kuzuya T, Honda T, Hayashi K, Nakano I, Hirooka Y, Goto H.

    Hepatol Res   Vol. 46 ( 6 ) page: 601-6   2015.10

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    DOI: 10.1111/hepr.12593.

  118. *Raloxifene Ameliorates Liver Fibrosis of Nonalcoholic Steatohepatitis Induced by Choline-Deficient High-Fat Diet in Ovariectomized Mice. Reviewed International journal

    Luo F, Ishigami M, Achiwa K, Ishizu Y, Kuzuya T, Honda T, Hayashi K, Ishikawa T, Katano Y, Goto H.

    Dig Dis Sci   Vol. 60 ( 9 ) page: 2730-2739   2015.9

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  119. Early Clinical Response after 2 Weeks of Sorafenib Therapy Predicts Outcomes and Anti-Tumor Response in Patients with Advanced Hepatocellular Carcinoma. Reviewed International journal

    Kuzuya T, Ishigami M, Ishizu Y, Honda T, Hayashi K, Katano Y, Hirooka Y, Ishikawa T, Nakano I, Goto H.

    ProS One.   Vol. 10 ( 9 ) page: e0138776   2015.9

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    DOI: 10.1371/journal.pone.0138776

  120. Reactivation of resolved infection with the hepatitis B virus immune escape mutant G145R during dasatinib treatment for chronic myeloid leukemia. Reviewed International journal

    Ando T, Kojima K, Isoda H, Eguchi Y, Honda T, Ishigami M, Kimura S

    International journal of hematology   Vol. 102 ( 3 ) page: 379 - 82   2015.9

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    DOI: 10.1007/s12185-015-1788-y

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  121. Association between responses to interferon therapy and genetic variation in interferon -28B and the core region of hepatitis C virus gentype 3a Reviewed International journal

    Yamada K, Ishigami M, Kuzuya T, Honda T, Hayashi K, Goto H.

    J Med Virol.   Vol. 87 ( 8 ) page: 1361-1367   2015.8

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  122. Effect of hyperglycemia on hepatocellular carcinoma development in diabetes. Reviewed International journal

    Niwa Y, Ishikawa K, Ishigami M, Honda T, Achiwa K, Izumoto T, Maekawa R, Hosokawa K, Iida A, Seino Y, Hamada Y, Goto H, Oiso Y, Arima H, Tsunekawa S.

    Biochem Biophys Res Commun   Vol. 463 ( 3 ) page: 344 - 350   2015.7

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  123. Predictive Ability of Laboratory Indices for Liver Fibrosis in Patients with Chronic Hepatitis C after the Eradication of Hepatitis C Virus. Reviewed International journal

    Tachi Y, Hirai T, Toyoda H, Tada T, Hayashi K, Honda T, Ishigami M, Goto H, Kumada T.

    ProS One.   Vol. 10 ( 7 ) page: e0133515   2015.7

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  124. Evaluation of Liver Function in Patients With Liver Cirrhosis-Comparison of Child-Pugh Score and MELD Score Reviewed International journal

    Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Onishi Yasuharu, Kamei Hideya, Ogura Yasuhiro, Goto Hidemi

      Vol. 99   page: 170 - 170   2015.7

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    Web of Science

  125. *Hepatitis B e antigen and hepatitis B surface antigen seroclearance with emergence of lamivudine-associated mutation and core mutation after elevation of CD4 in a patient with hepatitis B and HIV Reviewed International journal

    Honda T, Ishigami M, Luo F, Ishizu Y, Kuzuya T, Hayashi K, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Katano Y, Goto H.

    Internal Medicine   Vol. 54 ( 6 ) page: 585-590   2015.6

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  126. Endoscopic treatment of esophageal varices on hemophilic patients with liver cirrohosis Reviewed International journal

    Ishizu Y, Ishigami M, Kuzuya T, Honda T, Hayashi K, Goto H.

    Gastrointest Endosc   Vol. 81 ( 4 ) page: 1059-1060   2015.4

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  127. *Effect of Peginterferon alfa-2b and Ribavirin on Hepatocellular Carcinoma Prevention in Older Patients with Chronic Hepatitis C Reviewed International journal

    Honda T, Ishigami M, Hayashi H, Ishizu Y, Kuzuya T, Hayashi K, Itoh A, Hirooka Y, Nakano I, Ishikawa T, Urano F, Yoshioka K, Toyoda H, Kumada T, Katano Y, Goto H.

    J Gastroenterol Hepatol   Vol. 30 ( 2 ) page: 321 - 328   2015.2

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    DOI: 10.1111/jgh.12703

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    PubMed

  128. Progressive fibrosis significantly correlates with hepatocellular carcinoma in patients with a sustained virological response. Reviewed International journal

    Tachi Y, Hirai T, Miyata A, Ohara K, Iida T, Ishizu Y, Honda T, Kuzuya T, Hayashi K, Ishigami M, Goto H.

    Hepatol Res.   Vol. 45 ( 2 ) page: 238 - 246   2015.1

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    DOI: 10.1111/hepr.12331.

  129. Association of interleukin 28B polymorphism and mutations in the NS5A region of hepatitis C virus genotype 2 with interferon responsiveness Reviewed International journal

    Hayashi K, Katano Y, Ishuzu Y, Kuzuya T, Honda T, Ishigami M, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Yoshioka K, Toyoda H, Kumada T, Goto H.

    J Gastroenterol Hepatol   Vol. 30 ( 1 ) page: 178-183   2015.1

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  130. Transarterial chemoembolization for hepatocellular carcinoma: A review of techniques. Reviewed International journal

    Imai N, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, Hirooka Y, Goto H

    World journal of hepatology   Vol. 6 ( 12 ) page: 844 - 50   2014.12

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    DOI: 10.4254/wjh.v6.i12.844

    PubMed

  131. Frequent incidence of escape mutants after successful hepatitis B vaccine response and stopping of nucleos(t)ide analogues in liver transplant recipients Reviewed International journal

    Ishigami M, Honda T, Ishizu Y, Onishi Y, Kamei H, Hayashi K, Ogura Y, Hirooka Y, Goto H.

    Liver Transpl.   Vol. 20 ( 10 ) page: 1211-1120   2014.10

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  132. A pediatric case of hepatitis B virus subgenotype A2 in Japan. Reviewed International journal

    Hayashi K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Ito Y, Kimura H, Katano Y, Goto H

    Clinical journal of gastroenterology   Vol. 6 ( 5 ) page: 383 - 5   2013.10

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    DOI: 10.1007/s12328-013-0402-1

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  133. The relationship between the fever and the disappearance or decrease of lesion contrast on contrast enhanced CT images after 2 weeks of sorafenib treatment for patients with advanced hepatocellular carcinoma Reviewed

    KUZUYA Teiji, ISHIGAMI Masatoshi, NIINOMI Takurou, IMAI Norihiro, ACHIWA Kouichi, ARAKAWA Takahiro, YAMADA Keiichi, NAKANO Satoshi, ISHIZU Yoji, HONDA Takashi, HAYASHI Kazuhiko, ISHIKAWA Tetsuya, NAKANO Isao, KATANO Yoshiaki, ITOH Akihiro, HIROOKA Yoshiki, GOTO Hidemi

    Kanzo   Vol. 54 ( 7 ) page: 505 - 506   2013.7

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    We investigated the relationship between the fever and the disappearance or decrease of lesion contrast on contrast enhanced CT images after 2 weeks of sorafenib treatment for patients with advanced hepatocellular carcinoma (HCC). Subjects were 64 patients who began sorafenib therapy. Contrast enhanced CT images were taken at baseline and after 2 weeks of sorafenib treatment. In patients with fever, the ratio of patients demonstrating the disappearance or decrease of lesion contrast on contrast enhanced CT images was significantly higher than in those without fever (91.3% and 61.0%, respectively, p=0.010, Fisher's exact probability test). The results suggested the relationship between the fever and contrast change on contrast enhanced CT.<br>

    DOI: 10.2957/kanzo.54.505

  134. An increase in lesion density can predict lower local recurrence after transarterial chemoembolization in patients with hepatocellular carcinoma. Reviewed International journal

    Imai N, Katano Y, Kuzuya T, Honda T, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Goto H.

    Hepatogastroenterology   Vol. 60 ( 125 ) page: 965 - 970   2013.6

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  135. *Comparison of the efficacy of ribavirin plus peginterferon alfa-2b for chronic hepatitis C infection in patients with and without coagulation disorders Reviewed International journal

    Honda T, Katano Y, Kuzuya T, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Nakano I, Ishikawa T, Toyoda H, Kumada T, Yamamoto K, Matsushita T, Kojima T, Takamatsu J, Goto H.

    J Med Virol.   Vol. 85 ( 2 ) page: 228 - 234   2013.2

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  136. Pegylated interferon monotherapy in patients with chronic hepatitis C with low viremia and its relationship to mutations in the NS5A region and the single nucleotide polymorphism of interleukin-28B. Reviewed International journal

    Hayashi K, Katano Y, Masuda H, Ishizu Y, Kuzuya T, Honda T, Ishigami M, Itoh A, Hirooka Y, Nakano I, Ishikawa T, Urano F, Yoshioka K, Toyoda H, Kumada T, Goto H.

    Hepatol Res   Vol. 43 ( 6 ) page: 580-588   2013

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  137. Clinical trial of percutaneous radio frequency ablation therapy by two-step insertion method using VirtuTRAX<sup>TM</sup> instrument navigator Reviewed

    Kuzuya Teiji, Hayashi Kazuhiko, Ishigami Masatoshi, Ishikawa Tetsuya, Nakano Isao, Katano Yoshiaki, Itoh Akihiro, Hirooka Yoshiki, Izumi Namiki, Goto Hidemi, Ishizu Yoji, Niinomi Takurou, Imai Norihiro, Achiwa Kouichi, Arakawa Takahiro, Yamada Keiichi, Nakano Satoshi, Honda Takashi

    Kanzo   Vol. 54 ( 12 ) page: 850 - 853   2013

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    We performed percutaneous radio frequency ablation (RFA) therapy by two-step insertion method using VirtuTRAX<sup>TM</sup> (GE Healthcare, USA) instrument navigator. Subjects were 16 patients (23 nodules) with hepatocellular carcinoma. VirtuTRAX<sup>TM</sup> position sensor was attached to the hilt of 14-gauge outer needle. In all cases, we could perform 17- gauge Cool-tip RFA without the positional gap between the virtual tract and the actual needle which was caused by the deflection of the needle. The reasons without causing the positional gap were that the outer needle was more rigid than Cool-tip needle, and that it was inserted using initial insertion of a 21-gauge guided needle. RFA by two-step insertion method using VirtuTRAX<sup>TM</sup> is suggested to be more safe and effective than conventional RFA.

    DOI: 10.2957/kanzo.54.850

  138. Role of naofen in apoptosis of hepatocytes induced by lipopolysaccharide through mitochondrial signaling in rats Reviewed International journal

    Fan JH, Feng GG, Huang L, Tsunekawa K, Honda T, Katano Y, Hirooka Y, Goto H, Kandatsu N, Ando K, Fujiwara Y, Koide T, Okada S, Ishikawa N.

    Hepatol Res   Vol. 42 ( 7 ) page: 696-705   2012.7

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  139. Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C Reviewed International journal

    Ishizu Yoji, Katano Yoshiaki, Honda Takashi, Hayashi Kazuhiko, Ishigami Masatoshi, Itoh Akihiro, Hirooka Yoshiki, Nakano Isao, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 27 ( 6 ) page: 1112 - 1116   2012.6

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    DOI: 10.1111/j.1440-1746.2011.06976.x

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  140. Prevalence of hepatitis C virus genotype 1a in Japan and correlation of mutations in the NS5A region and single-nucleotide polymorphism of interleukin-28B with the response to combination therapy with pegylated-interferon-alpha 2b and ribavirin. Reviewed International journal

    Hayashi K, Katano Y, Kuzuya T, Tachi Y, Honda T, Ishigami M, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Urano F, Yoshioka K, Toyoda H, Kumada T, Goto H.

    J Med Virol.   Vol. 84 ( 3 ) page: 438-444   2012.3

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  141. Predictive value of early viral dynamics during peginterferon and ribavirin combination therapy based on genetic polymorphisms near the IL28B gene in patients infected with HCV genotype 1b. Reviewed International journal

    Toyoda H, Kumada T, Tada T, Hayashi K, Honda T, Katano Y, Goto H, Kawaguchi T, Murakami Y, Matsuda F.

    J Med Virol.   Vol. 84 ( 1 ) page: 61-70   2012.1

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  142. Association of interleukin 28B and mutations in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy Reviewed International journal

    Hayashi Kazuhiko, Katano Yoshiaki, Honda Takashi, Ishigami Masatoshi, Itoh Akihiro, Hirooka Yoshiki, Ishikawa Tetsuya, Nakano Isao, Yoshioka Kentaro, Toyoda Hidenori, Kumada Takashi, Goto Hidemi

    LIVER INTERNATIONAL   Vol. 31 ( 9 ) page: 1359 - 1365   2011.10

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    DOI: 10.1111/j.1478-3231.2011.02571.x

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    PubMed

  143. Antiviral combination therapy with peginterferon and ribavirin does not induce a therapeutically resistant mutation in the HCV core region regardless of genetic polymorphism near the IL28B gene. Reviewed International journal

    Toyoda H, Kumada T, Hayashi K, Honda T, Katano Y, Goto H, Kawaguchi T, Murakami Y, Matsuda F.

    J Med Virol.   Vol. 83 ( 9 ) page: 1559-1564   2011.9

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  144. Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C. Reviewed

    Ishizu Y, Katano Y, Honda T, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Nakano I, Goto H.

    J Gastroenterol Hepatol     2011

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    DOI: 10.1111/j.1440-1746.2011.06976

  145. Association between HCV amino acid substitutions and outcome of peginterferon andribavirin combination therapy in HCV genotype 1b and high viral load. Reviewed

    Toyoda H, Kumada T, Tada T, Arakawa T, Hayashi K, Honda T, Katano Y, Goto H.

    JGastroenterol Hepatol.   Vol. 25 ( 6 ) page: 1072-1078   2010.7

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  146. *Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years andolder with chronic hepatitis C. Reviewed International journal

    Honda T, Katano Y, Shimizu J, Ishizu Y, Doizaki M, Hayashi K, Ishigami M,Itoh A, Hirooka Y, Nakano I, Urano F, Yoshioka K, Toyoda H, Kumada T, Goto H.

    Liver Int.   Vol. 30 ( 4 ) page: 527 - 537   2010.4

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    DOI: 10.1111/j.1478-3231.2009.02064.x

  147. Impact of amino acid substitutions in the hepatitis Cvirus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C. Reviewed International journal

    Tachi Y, Katano Y, Honda T, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Nakano I, Samejima Y, Goto H.

    Liver Int.   Vol. 30 ( 4 ) page: 554-559   2010.4

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  148. Naofen, a novel WD40-repeatprotein, mediates spontaneous and tumor necrosis factor-induced apoptosis. Reviewed International journal

    Feng GG, Li C, Huang L, Tsunekawa K, Sato Y, Fujiwara Y, Komatsu T, Honda T,Fan JH, Goto H, Koide T, Hasegawa T, Ishikawa N.

    Biochem Biophys Res Commun.   Vol. 394 ( 1 ) page: 153-157   2010.3

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  149. Mutations in the interferonsensitivity-determining region of hepatitis C virus genotype 2a correlate withresponse to pegylated-interferon-alpha 2a monotherapy. Reviewed International journal

    Hayashi K, Katano Y, Honda T, Ishigami M, Itoh A, Hirooka Y, Nakano I, Urano F, Yoshioka K, Toyoda H, Kumada T, Goto H. Mutations in the interferonsensitivity-determining region of hepatitis C virus genotype 2a correlate withresponse to pegylated-interferon-alpha 2a monotherapy.

    J Med Virol.   Vol. 81 ( 3 ) page: 459-466   2009.3

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  150. Comparison of biochemical safety between PEG-IFN alpha-2a and PEG-IFNalpha-2b. Reviewed International journal

    Katano Y, Kumada T, Nakano I, Toyoda H, Ishigami M, Hayashi K, Honda T, Goto H.

    Hepatogastroenterology.   Vol. 56 ( 90 ) page: 485-491   2009.3

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  151. Correlation of serum ribavirin concentration with pretreatment renal function estimates inpatients with chronic hepatitis C receiving combination antiviral therapy withpeginterferon and ribavirin. Reviewed International journal

    Toyoda H, Kumada T, Kiriyama S, Sone Y, Tanikawa M, Hisanaga Y, Kanamori A,Atsumi H, Nakano S, Arakawa T, Honda T, Hayashi K, Katano Y, Goto H.

    J Viral Hepat.   Vol. 15 ( 9 ) page: 651-658   2008.9

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  152. Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus Reviewed International journal

    Kuzuya Teiji, Katano Yoshiaki, Nakano Isao, Hirooka Yoshiki, Itoh Akihiro, Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Goto Hidemi, Fujita Yuko, Shikano Rie, Muramatsu Yuji, Bajotto Gustavo, Tamura Tomohiro, Tamura Noriko, Shimomura Yoshiharu

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 373 ( 1 ) page: 94 - 98   2008.8

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    DOI: 10.1016/j.bbrc.2008.05.167

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  153. Use of the Model for End-Stage Liver Disease (MELD) score topredict 1-year survival of Japanese patients with cirrhosis and to determine who will benefit from living donor liver transplantation. Reviewed International journal

    Ishigami M, Honda T, Okumura A, Ishikawa T, Kobayashi M, Katano Y, FujimotoY, Kiuchi T, Goto H.

    J Gastroenterol.   Vol. 43 ( 5 ) page: 363-368   2008.7

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  154. Association of hepatitis B virussubgenotypes and basal core promoter/precore region variants with the clinicalfeatures of patients with acute hepatitis. Reviewed International journal

    Hayashi K, Katano Y, Takeda Y, Honda T, Ishigami M, Itoh A, Hirooka Y, NakanoI, Yoshioka K, Toyoda H, Kumada T, Goto H.

    J Gastroenterol.   Vol. 43 ( 7 ) page: 558-564   2008.7

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  155. *Effect of Ribavirin, Combination with Interferon in Patients with Hepatitis C, on the Bleeding Risk Associated With Selective Serotonin Reuptake Inhibitors Reviewed International journal

    Takashi Honda,Yoshiaki Katano,Hidenori Toyoda,Kazuhiko Hayashi,.Masatoshi Ishigami,Isao Nakano,Hidemi Goto,Koji Yamamoto,Junki Takamatsu

    J Clin Psychatry   Vol. 69 ( 4 ) page: 679 - 680   2008.4

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  156. Prevalence of Hepatitis E Virus IgG Antibody in Japanese Patients with Hemophilia Reviewed International journal

    Toyoda H, Honda T, Hayashi K, Katano Y, Goto H, Kumada T, Takahashi K, Abe N, Mishiro S, Takamatsu J

    Intervirology   Vol. 29 ( 51 ) page: 21-25   2008.2

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  157. Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma. Reviewed International journal

    Kuzuya T, Katano Y, Kumada T, Toyoda H, Nakano I, Hirooka Y, Itoh A, Ishigami M, Hayashi K, Honda T, Goto H.

    J Gastroenterol Hepatol.   Vol. 22 ( 11 ) page: 1929-1935   2007.11

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  158. *Efficacy of ribavirin plus Efficacy of ribavirin plus interferon-α in patients aged >or=60 years with chronic hepatitis C. Reviewed International journal

    Honda T, Katano Y, Urano F, Murayama M, Hayashi K, Ishigami M, Nakano I, Yoshioka K, Toyoda H, Kumada T, Goto H

    J Gastroenterol Hepatol.   Vol. 22 ( 7 ) page: 989 - 995   2007.7

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    DOI: 10.1111/j.1440-1746.2006.04773.x

  159. Changes in circulating cytokine levels and lymphocyte subsets in healthy liver donors after partial hepatectomy Reviewed International journal

    Nakashima S, Katano Y, Nakano I, Hirooka Y, Ito A, Ishigami M, Hayashi K, Honda T, Goto H

    Hepatol Res.   Vol. 37 ( 10 ) page: 878-84   2007.6

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  160. Comparison of hepatitis B virus subgenotypes in patients with acute and chronic hepatitis B and absence of lamivudine-resistant strains in acute hepatitis B in Japan. Reviewed International journal

    Hayashi K, Katano Y, Takeda Y, Honda T, Ishigami M, Itoh A, Hirooka Y, Nakano I, Yano M, Goto H, Yoshioka K, Toyoda H, Kumada T.

    J Med Virol.   Vol. 79 ( 4 ) page: 366-373   2007.4

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  161. A mutation in the interferon sensitivity-determining region is associated with responsiveness to interferon-ribavirin combination therapy in chronic hepatitis patients infected with a Japan-specific subtype of hepatitis C virus genotype 1B Reviewed International journal

    Murayama M, Katano Y, Nakano I, Ishigami M, Hayashi K, Honda T, Hirooka Y, Itoh A, Goto H

    J Med Virol.   Vol. 79 ( 1 ) page: 35-40   2007.1

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  162. Difference of HBV genotype distribution between acute hepatitis and chronic hepatitis in Japan Reviewed International journal

    Takeda Y, Katano Y, Hayashi K, Honda T, Yokozaki S, Nakano I, Yano M, Yoshioka K, Toyoda H, Kumada T, Goto H

    Infection   Vol. 34 ( 4 ) page: 201-207   2006.8

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  163. Mutations in carboxy-terminal part of E2 including PKR/eIF2alpha phosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b: their correlation with response to interferon monotherapy and viral load Reviewed International journal

    Ukai K, Ishigami M, Yoshioka K, Kawabe N, Katano Y, Hayashi K, Honda T, Yano M, Goto H

    World J Gastroenterol.   Vol. 12 ( 23 ) page: 3722-3728   2006.6

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  164. Clofibrate treatment promotes branched-chain amino acid catabolism and decreases the phosphorylation state of mTOR, eIF4E-BP1, and S6K1 in rat liver Reviewed International journal

    Ishiguro H, Katano Y, Nakano I, Ishigami M, Hayashi K, Honda T, Goto H, Bajotto G, Maeda K, Shimomura Y

    Life Sci.   Vol. 79 ( 8 ) page: 737 - 743   2006.4

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  165. *Anti-HCV agent, ribavirin, elevates the activity of clotting factor VII in patients with hemophilia: a possible mechanism of decreased events of bleeding in patients with hemophilia by ribavirin Reviewed

    Yamamoto K, Honda T, Matsushita T, Kojima T, Takamatsu J

    J Thromb Haemost.   Vol. 4 ( 2 ) page: 469-470   2006.2

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  166. Treatment of chronic hepatitis C with interferon alone or combined with ribavirin in Japan Reviewed International journal

    Kumada T, Toyoda H, Honda T, Kuzuya T, Katano Y, Nakano I, Goto H

    Intervirology   Vol. 49 ( 1-2 ) page: 112-118   2006.1

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  167. Branched-chain amino acid catabolism in exercise and liver disease Reviewed International journal

    Shimomura Y, Honda T, Shiraki M, Murakami T, Sato J, Kobayashi H, Mawatari K, Obayashi M, Harris RA

    J Nutr.   Vol. 136 ( 1 ) page: 250S-253S   2006.1

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  168. Recurrent hepatocellular carcinoma with rapid growth after cardiac surgery Reviewed International journal

    Shimizu H, Katano Y, Nagano K, Yokozaki S, Shimizu F, Naito T, Hayashi K, Shimizu Y, Honda T, Kaneko T, Akita S, Nakano I, Fukuda Y

    Hepatogastroenterology   Vol. 52 ( 66 ) page: 1863-1866   2005.11

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  169. Clearance of GB virus C during highly active antiretroviral therapy and course of HIV disease progression in HIV-infected patients with hemophilia. Reviewed International journal

    Toyoda H, Honda T, Katano Y, Goto H, Takamatsu J

    Eur J Clin Microbiol Infect Dis.   Vol. 24 ( 9 ) page: 645-646   2005.9

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  170. *Ribavirin and use of clotting factors in patients with hemophilia and chronic hepatitis C Reviewed International journal

    Honda T, Toyoda H, Hayashi K, Katano Y, Yano M, Nakano I, Yoshioka K, Goto H, Yamamoto K, Takamatsu J

    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION   Vol. 293 ( 10 ) page: 1190 - 1192   2005.3

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  171. Changes in hepatitis C virus (HCV) antibody status in patients with chronic hepatitis C after eradication of HCV infection by interferon therapy Reviewed International journal

    Toyoda H, Kumada T, Kiriyama S, Sone Y, Tanikawa M, Hisanaga Y, Kuzuya T, Honda T, Hayashi K, Nakano I, Katano Y, Goto H

    Clin Infect Dis.   Vol. 40 ( 6 ) page: e49-54   2005.3

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  172. *Regulation of branched-chain amino acid metabolism and pharmacological effects of branched-chain amino acids Reviewed International journal

    Shimomura Y, Murakami T, Nagasaki M, Honda T, Goto H, Kotake K, Kurokawa T, Nonami T

    Hepatol Res.   Vol. 30S   page: 3-8   2004.12

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  173. Prevalence and clinical implications of occult hepatitis B viral infection in hemophilia patients in Japan Reviewed International journal

    Toyoda H, Hayashi K, Murakami Y, Honda T, Katano Y, Nakano I, Goto H, Kumada T, Takamatsu J

    J Med Virol.   Vol. 73 ( 2 ) page: 195-199   2004.6

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  174. Changes in the characteristics and survival rate of hepatocellular carcinoma from 1976 to 2000: analysis of 1365 patients in a single institution in Japan Reviewed International journal

    Toyoda H, Kumada T, Kiriyama S, Sone Y, Tanikawa M, Hisanaga Y, Hayashi K, Honda T, Kitabatake S, Kuzuya T, Nonogaki K, Kasugai T, Shimizu J

    Cancer   Vol. 100 ( 11 ) page: 2415 - 2421   2004.6

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  175. *Effects of liver failure on branched-chain alpha-keto acid dehydrogenase complex in rat liver and muscle: comparison between acute and chronic liver failure Reviewed International journal

    Honda T, Fukuda Y, Nakano I, Katano Y, Goto H, Nagasaki M, Sato Y, Murakami T, Shimomura Y.

    J Hepatol.   Vol. 40 ( 3 ) page: 439 - 445   2004.3

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    DOI: 10.1016/j.jhep.2003.11.003

  176. Influence of age, sex, and degree of liver fibrosis on the association between serum alanine aminotransferase levels and liver inflammation in patients with chronic hepatitis C Reviewed International journal

    Toyoda H, Kumada T, Kiriyama S, Sone Y, Tanikawa M, Hisanaga Y, Hayashi K, Honda T, Kuzuya T

    Dig Dis Sci.   Vol. 49 ( 2 ) page: 295-299   2004.2

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  177. Effects of liver failure on the enzymes in the branched-chain amino acid catabolic pathway. Biochem Biophys Res Commun Reviewed International journal

    Shimomura Y, Honda T, Goto H, Nonami T, Kurokawa T, Nagasaki M, Murakami T

    Biochem Biophys Res Commun.   Vol. 313 ( 2 ) page: 381-385   2004.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  178. *Comparison of contrast-enhanced harmonic ultrasonography and power Doppler ultrasonography for depicting vascularity of hepatocellular carcinoma identified by angiography-assisted CT Reviewed International journal

    Honda T, Kumada T, Kiriyama S, Sone Y, Tanikawa M, Hisanaga Y, Toyoda H, Ishiguro H, Ogawa S, Takeshima K, Kawachi T, Hibi T, Hayashi K, Katano Y, Fukuda Y, Goto H.

    Hepatol Res.   Vol. 27 ( 4 ) page: 314 - 321   2003.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  179. Characteristics and prognosis of hepatocellular carcinoma detected in sustained responders to interferon therapy for chronic hepatitis C. Reviewed International journal

    Toyoda H, Kumada T, Hayashi K, Honda T, Morita K, Nishimura D, Imada K, Imoto M, Horiguchi Y, Nakano H, Nakano I, Fukuda Y

    Cancer Detection and Prevention   Vol. 27 ( 6 ) page: 498-502   2003.6

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  180. Liver Damage Related with Hepatitis C and Human Immune Deficiency Coinfection Reviewed International journal

    HAYASHI K., TAKAMATSU J., HONDA T., YOKAZAKI S., NAGANO K., TOYODA H., KATANO Y., NAKANO I., FUKUDA Y., GOTO H.

    The Journal of AIDS Research   Vol. 5 ( 2 ) page: 101 - 106   2003

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society for AIDS Research  

    DOI: 10.11391/aidsr1999.5.101

  181. Liver dysfunction among workers handling 5-nitro-o-toluidine Reviewed International journal

    Shimizu H, Kumada T, Nakano S, Kiriyama S, Sone Y, Honda T, Watanabe K, Nakano I, Fukuda Y, Hayakawa T

    GUT   Vol. 50 ( 2 ) page: 266 - 270   2002.2

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    Web of Science

  182. Incidence of hepatocellular carcinoma in chronic hepatitis C after interferon therapy Reviewed International journal

    Hayashi K, Kumada T, Nakano S, Takeda I, Kiriyama S, Sone Y, Toyoda H, Shimizu H, Honda T

    HEPATO-GASTROENTEROLOGY   Vol. 49 ( 44 ) page: 508 - 512   2002

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    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  183. Analysis of hepatocellular carcinoma tumor growth detected in sustained responders to interferon in patients with chronic hepatitis C Reviewed International journal

    Toyoda H, Kumada T, Honda T, Hayashi K, Katano Y, Nakano I, Hayakawa T, Fukuda Y

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   Vol. 16 ( 10 ) page: 1131 - 1137   2001.10

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    Web of Science

  184. Effect of the dose and duration of interferon-alpha therapy on the incidence of hepatocellular carcinoma in noncirrhotic patients with a nonsustained response to interferon for chronic hepatitis C Reviewed International journal

    Toyoda H, Kumada T, Nakano S, Takeda I, Sugiyama K, Kiriyama S, Sone Y, Tanikawa M, Hisanaga Y, Hayashi K, Honda T

    ONCOLOGY   Vol. 61 ( 2 ) page: 134 - 142   2001

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  185. Long-term follow-up of sustained responders to interferon therapy, in patients with chronic hepatitis C Reviewed International journal

    Toyoda H, Kumada T, Tokuda A, Horiguchi Y, Nakano H, Honda T, Nakano S, Hayashi K, Katano Y, Nakano I, Hayakawa T, Nishimura D, Kato K, Imada K, Imoto M, Fukuda Y

    JOURNAL OF VIRAL HEPATITIS   Vol. 7 ( 6 ) page: 414 - 419   2000.11

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    Web of Science

▼display all

Presentations 146

  1. Possible prediction of functional cure by HBV core mutations in patients with chronic hepatitis B

    Takashi Honda, Masatoshi Ishigami, Takafumi Yamamoto, Yosuke Inukai, Yoshiaki Sugiyama, Naoki Yoshioka, Kazuhiro Mizuno, Hisanori Muto, Shinya Yokoyama, Taku Tanaka, Kenta Yamamoto, Takanori Ito, Norihiro Imai, Yoji Ishizu, Mitsuhiro Fujishiro

    2021.11.4 

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    Event date: 2021.11

    Language:English   Presentation type:Poster presentation  

  2. 多孔質ガラス膜-薬液混合コネクタを用いた肝動脈化学塞栓術の治療成績

    今井則博、山本 健太、伊藤 隆徳、石津 洋二、本多 隆、石上 正敏、藤城 光弘

    JDDW2021  2021.11.4  肝臓学会

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    Event date: 2021.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸   Country:Japan  

  3. Rifaximin投与患者におけるアンモニア測定の意義

    石津 洋二、石上 正敏、山本 崇文、犬飼 庸介、杉山 由晃、吉岡 直輝、水野 和幸、武藤 久哲、横山 晋也、山本 健太、伊藤 隆徳、今井則博、本多 隆、藤城 光弘

    JDDW2021  2021.11.4  肝臓学会

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    Event date: 2021.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸  

  4. 慢性肝疾患患者における筋肉量,血清分岐鎖アミノ酸濃度,細菌叢の相関に関する検討

    山本 健太、本多 隆、藤城 光弘

    JDDW2021  2021.11.4  肝臓学会

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  5. Usefulness of core I97L in predicting the efficacy of nucleos(t)ide analogue therapy in patients with hepatitis B International conference

    Takashi Honda, Masatoshi Ishigami, Kenta Yamamoto, Takanori Ito, Norihiro Imai, Yoji Ishizu, Mitsuhiro Fujishiro

    AASLD2021  2021.11 

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    Event date: 2021.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  6. Differences in the intestinal microbiome associated with diarrhea during lenvatinib treatment for hepatocellular carcinoma International conference

    Yosuke Inukai, Kenta Yamamoto, Takashi Honda, Takanori Ito, Norihiro Imai, Yoji Ishizu, Masanao Nakamura, Hiroki Kawashima, Masatoshi Ishigami, Mitsuhiro Fujishiro

    AASLD2021  2021.11 

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    Event date: 2021.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  7. The impact of hepatitis C virus eradication on hepatocarcinogenesis in haemophiliacs International conference

    Inukai Yosuke, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishigami Masatoshi

    EASL2021  2021.7 

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    Event date: 2021.7

    Language:English   Presentation type:Poster presentation  

  8. 肝硬変による入院イベントと腸内細菌叢の関連性

    山本健太、本多 隆、山本 崇文、犬飼 庸介、杉山 由晃、吉岡 直輝、水野 和幸、武藤 久哲、横山 晋也、伊藤 隆徳、今井則博、石津 洋二、石上 正敏、藤城 光弘

    第57回日本肝臓学会総会  2021.6.18  肝臓学会

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道(Web)   Country:Japan  

  9. 核酸アナログ治療中止可能予測因子とHBVコア変異の関係

    本多 隆、石上 雅敏、山本 崇文、犬飼 庸介、杉山 由晃、吉岡 直輝、水野 和幸、武藤 久哲、横山 晋也、山本 健太、伊藤 隆徳、今井則博、石津 洋二、石川 哲也、藤城 光弘

    第57回日本肝臓学会総会  2021.6.18  肝臓学会

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道(Web)   Country:Japan  

  10. Functional cureに関与するコア領域のアミノ酸変異がHBVライフサイクルに与える影響の解析

    加藤 孝宣、山田 典栄、本多 隆

    第57回日本肝臓学会総会  2021.6.1 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:北海道(Web)   Country:Japan  

  11. The impact of hepatitis C virus eradication on hepatocarcinogenesis in haemophiliacs International conference

    Yosuke Inukai, Norihiro Imai, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami,Mitsuhiro Fujishiro

    2021.6 

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    Event date: 2021.6

    Language:English   Presentation type:Poster presentation  

  12. 慢性肝疾患患者における生活習慣・排便状況調査と腸内細菌叢に与える影響

    山本 健太、本多 隆、藤城 光弘

    第107回消化器病学会総会  2021.4.17  消化器病学会

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    Event date: 2021.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京(Web)   Country:Japan  

  13. B型慢性肝炎におけるFunctional cureに関連するHBVコア変異

    本多 隆、加藤 孝宣、藤城 光弘

    第107回消化器病学会総会   2021.4.15  消化器病学会

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    Event date: 2021.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京(Web)   Country:Japan  

  14. 肝硬変患者に対する分岐アミノ酸投与による腸内細菌叢の違い

    犬飼庸介、本多 隆、山本健太、山本崇文、杉山由晃、吉岡直輝、水野和幸、武藤久哲、横山晋也、田中 卓、伊藤隆徳、石津洋二、葛谷貞二、石上正敏、藤城光弘

    JDDW2020  2020.11 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Poster presentation  

  15. 非肝癌症例と肝発癌症例の違いに関与する腸内細菌の検討

    本多 隆, 石上 雅敏, 山本 崇文, 犬飼 庸介, 杉山 由晃, 吉岡 直輝, 水野 和幸, 武藤 久哲, 横山 晋也, 田中 卓, 山本 健太, 伊藤 隆徳, 石津 洋二, 葛谷 貞二, 石川 哲也, 藤城 光弘

    JDDW2020  2020.11 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Poster presentation  

  16. SAFETY AND EFFICACY OF PERCUTANEOUS RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA PATIENTS WITH HEMOPHILIA International conference

    Yamamoto Takafumi, Ishigami Masatoshi, Yamamoto Kenta, Ito Takanori, Imai Norihiro, Lshizu Yoji, Honda Takashi, Fujishiro Mitsuhiro

    AASLD2020  2020.11 

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    Event date: 2020.11

    Language:English   Presentation type:Poster presentation  

  17. IMPROVEMENT OF LIVER FUNCTIONAL RESERVE AFTER SVR IN HCV-PATIENTS WITH COMPENSATED, SEVERE FIBROSIS BY IFN-FREE, DAA COMBINATION TREATMENT-IMPACT OF PRETREATMENT SERUM AFP LEVELS International conference

    Ishigami Masatoshi, Honda Takashi, Ishizu Yoji, Imai Norihiro, Ito Takanori, Yamamoto Kenta, Fujishiro Mitsuhiro

    AASLD2020  2020.11 

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    Event date: 2020.11

    Language:English   Presentation type:Poster presentation  

  18. GUT MICROBIOTA ASSOCIATED WITH THE DIFFERENCE BETWEEN PATIENTS WITH AND WITHOUT HEPATOCELLULAR CARCINOMA IN CHRONIC LIVER DISEASE International conference

    Honda Takashi, Ishigami Masatoshi, Yamamoto Kenta, Ito Takanori, Imai Norihiro, Ishizu Yoji, Fujishiro Mitsuhiro

    AASLD2020  2020.11 

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    Event date: 2020.11

    Language:English   Presentation type:Poster presentation  

  19. AMINO ACID POLYMORPHISM IN HEPATITIS B VIRUS ASSOCIATED WITH NATURAL CLEARANCE OF HBV DNA AND HBsAg International conference

    Honda Takashi, Yamada None, Murayama Asako, Kato Asuka, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Ishigami Masatoshi, Murakami Yoshiki, Ishikawa Tetsuya, Fujishiro Mitsuhiro, Kato Takanobu

    AASLD2020  2020.11 

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    Event date: 2020.11

    Language:English   Presentation type:Poster presentation  

  20. B型肝炎患者におけるFunctional cureと腸内細菌の関係

    本多 隆、石上雅敏、藤城光弘

    第106回消化器病学会総会  2020.8.11 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  21. 慢性肝疾患患者における腸内細菌叢のPredicted Functional Dysbiosisに影響を与える因子についての検討

    山本健太、本多 隆、石上雅敏

    第56回日本肝臓学会総会  2020.5.22 

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    Event date: 2020.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  22. B型肝炎症例におけるテノホビル ジソプロキシルフマル酸塩への切替えによるHBV DNA、HBs抗原、 ALT値の変化に関する検討

    本多 隆, 石上雅敏, 山本崇文, 犬飼庸介, 吉岡直輝, 水野和幸, 武藤久哲, 横山晋也, 田中卓, 山本健太, 伊藤隆徳, 石津洋二, 葛谷貞二, 石川哲也, 藤城光弘

    第56回日本肝臓学会総会  2020.5.22  第56回日本肝臓学会総会

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    Event date: 2020.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪  

  23. ASSOCIATION BETWEEN FASTING BREATH HYDROGEN LEVELS AND PANCREATIC EXOCRINE INEFFICIENCY International conference

    Uetsuki Kota, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Nakamura Masanao, Furukawa Kazuhiro, Ishigami Masatoshi, Honda Takashi, Fujishiro Mitsuhiro

    AGA2020  2020.5 

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    Event date: 2020.5

    Language:English   Presentation type:Poster presentation  

  24. EXAMINATION OF NEW PREDICTIVE FACTORS USING ENDOSCOPY AND SERUM CYTOKINE LEVELS FOR USTEKINUMAB IN CROHN'S DISEASE International conference

    Murate Kentaro, Maeda Keiko, Nakamura Masanao, Sugiyama Daisuke, Wada Hirotaka, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Nishikawa Hiriyoshi, Fujishiro Mitsuhiro

    AGA2020  2020.5 

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    Event date: 2020.5

    Language:English   Presentation type:Poster presentation  

  25. QUANTITATIVE EVALUATION OF TREATMENT EFFECT USING SHEAR WAVE ELASTOGRAPHY AND SHEAR WAVE DISPERSION IN AUTOIMMUNE PANCREATITIS International conference

    Suzuki Hirotaka, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Nakamura Masanao, Furukawa Kazuhiro, Ishigami Masatoshi, Honda Takashi, Fujishiro Mitsuhiro

    AGA2020  2020.5 

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    Event date: 2020.5

    Language:English   Presentation type:Poster presentation  

  26. C型肝癌症例に関連する腸内細菌の検討

    JDDW2019  2019.11.21 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Poster presentation  

  27. UTILITY OF THE ALBUMIN-BILIRUBIN SCORE FOR PREDICTING PROGNOSIS IN JAPANESE PATIENTS WITH PRIMARY BILIARY CHOLANGITIS: AN ANALYSIS USING TIME-DEPENDENT RECEIVER OPERATING CHARACTERISTICS International conference

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Yasuda Satoshi, Toyoda Hidenori, Kumada Takashi, Fujishiro Mitsuhiro

    AASLD2019  2019.10 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  28. CHANGES OF MICROBIOTA AFTER HEPATITIS C VIRUS ERADICATION International conference

    Honda Takashi, Ishigami Masatoshi, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Fujishiro Mitsuhiro

    AASLD2019  2019.10 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  29. NON-INVASIVE SCREENING FOR DETECTING ESOPHAGOGASTRIC VARICES IN CHILDREN WITH BILIARY ATRESIA International conference

    Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Shirota Chiyoe, Uchida Hiroo, Fujishiro Mitsuhiro

    AASLD2019  2019.10 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  30. INDICATION FOR HCC TREATMENT IN RECENT ERA-PROPOSAL OF THE NEW PRIORITY FOR LIVER TRANSPLANTATION IN PATIENTS WITH HCC International conference

    Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Fujishiro Mitsuhiro

    AASLD2019  2019.10 

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    Language:English   Presentation type:Poster presentation  

  31. The relationship between portal hypertension and the microbiome International conference

    Yamamoto K., Honda T., Hattori S., Pu L. Zorron Cheng Tao, Ito T., Yamamura T., Ishizu Y., Kuzuya T., Ishigami M., Fujishiro M.

    AGW2019  2019.9 

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    Event date: 2019.9

    Language:English   Presentation type:Poster presentation  

  32. Microbiota profile is markedly different for early and invasive colorectal cancer and is consistent throughout the colon International coauthorship International conference

    Pu L. Zorron Cheng Tao, Yamamoto K., Honda T., Hattori S., Nakamura M., Yamamura T., Burt A., Hirooka Y., Singh R., Fujishiro M.

    AGW2019  2019.9 

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    Event date: 2019.9

    Language:English   Presentation type:Poster presentation  

  33. Specific members of gut microbiota predict mucosal healing in Crohn's disease International conference

    Hattori S., Nakamura M., Yamamura T., Maeda K., Sawada T., Mizutani Y., Yamamoto K., Pu L. Zorron Cheng Tao, Honda T., Ishikawa T., Furukawa K., Ohno E., Miyahara R., Kawashima H., Fujishiro M.

    AGW2019  2019.9 

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    Event date: 2019.9

    Language:English   Presentation type:Poster presentation  

  34. 核酸アナログ治療症例におけるHBVcore変異とウイルス量、HBsAg、HBcrAgの関係

    本多 隆、石上雅敏、藤城光弘

    肝臓学会総会  2019.5.30 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  35. 慢性肝疾患例における肝発癌症例に関連する腸内細菌叢の検討

    本多 隆、石上雅敏、廣岡芳樹

    消化器病学会総会  2019.5.9 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  36. The optimal cut-off points of FIB-4 index for predicting the incidences of HCC and extra-hepatic malignancies in biopsyproven Japanese NAFLD patients International conference

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Fujishiro Mitsuhiro

    EASL2019  2019.4 

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    Event date: 2019.4

    Language:English   Presentation type:Poster presentation  

  37. The early clinical response at 2 weeks of lenvatinib therapy for patients with advanced HCC International conference

    Kuzuya Teiji, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Honda Takashi, Fujishiro Mitsuhiro

    EASL2019  2019.4 

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    Event date: 2019.4

    Language:English   Presentation type:Poster presentation  

  38. Serum Zinc levels as a prognostic factor for extra-hepatic carcinogenesis in Japanese patients with non-alcoholic liver disease International conference

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Fujishiro Mitsuhiro

    EASL2019  2019.4 

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    Event date: 2019.4

    Language:English   Presentation type:Oral presentation (general)  

  39. Association between gut microbiota and hepatocellular carcinoma in patients with chronic liver disease International conference

    Honda Takashi, Ishigami Masatoshi, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Fujishiro Mitsuhiro

    EASL2019  2019.4 

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    Event date: 2019.4

    Language:English   Presentation type:Poster presentation  

  40. Association between Core Mutations Induced By Interferon Therapy and Annual Decline Rate of Hbvdna in Chronic Hepatitis B Patients International conference

    Takashi Honda, Masatoshi Ishigami, Takanori Ito, Yoji Ishizu, Teiji Kuzuya and Yoshiki Hirooka,

    AASLD2018  2018.11.12 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  41. 自然経過及び治療症例におけるHBVcoreI97L変異とウイルス量,HBsAg減少の関係

    本多 隆、石上雅敏、廣岡芳樹

    JDDW2018  2018.11.12 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  42. C型肝炎ウイルス駆除による腸内細菌叢への影響

    本多 隆、石上雅敏、廣岡芳樹

    JDDW2018  2018.11.1 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  43. Novel Candidate Drugs That Target Cccdna of HBV International conference

    Murakami Yoshiki, Hayakawa Michiyo, Itami-Matsumoto Saari, Ando Mari, Yata Yutaka, Enomoto Masaru, Tamori Akihiro, Kawada Norifumi, Honda Takashi, Yano Yoshihiko, Iwadate Mitsuo, Umeyama Hideaki

    AASLD2018  2018.10 

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    Event date: 2018.10

    Language:English   Presentation type:Poster presentation  

  44. Late Relapse and Molecular Analysis of Hepatitis C Virus in Patients with Sustained Virological Response By All Oral Direct Acting Antivirals Therapy International conference

    Hayashi Kazuhiko, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishigami Masatoshi, Shimizu Yuko, Tachi Kousuke, Goto Hidemi

    AASLD2018  2018.10 

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    Event date: 2018.10

    Language:English   Presentation type:Poster presentation  

  45. Interferon-Free Antiviral Therapy Rapidly Improves Thrombocytopenia in Patients with Advanced Chronic Hepatitis C International conference

    Ishizu Yoji, Ishigami Masatoshi, Ito Takanori, Kuzuya Teiji, Honda Takashi, Hirooka Yoshiki

    AASLD2018  2018.10 

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    Event date: 2018.10

    Language:English   Presentation type:Poster presentation  

  46. Comparison of Gut Microbiota and Predicted Functional Metagenome in Hepatitis C Patients with and without Advanced Fibrosis Categorized By FIB4-Index International conference

    Yamamoto Kenta, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hirooka Yoshiki

    AASLD2018  2018.10 

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    Event date: 2018.10

    Language:English   Presentation type:Poster presentation  

  47. Association between Core Mutations Induced By Interferon Therapy and Annual Decline Rate of Hbvdna in Chronic Hepatitis B Patients International conference

    Honda Takashi, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Hirooka Yoshiki

    AASLD2018  2018.10 

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    Event date: 2018.10

    Language:English   Presentation type:Poster presentation  

  48. インターフェロン治療によるHBV core I97L変異の 誘導とHBV DNA及びHBsAg減少率に関する検討

    本多 隆、石上雅敏、後藤秀実

    第54回日本肝臓学会総会  2018.6.14 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  49. C型肝炎ウイルスの肝病態による腸内細菌叢の違いと駆除後の肝癌発症との関連

    本多 隆、石上雅敏、廣岡芳樹

    肝臓学会総会  2018.6.14 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  50. C型肝炎による肝発癌に関連する腸内細菌叢の検討

    本多 隆、廣岡芳樹、後藤秀実

    消化器病学会総会  2018.4.20 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

  51. Naturally occurring drug resitance substitutions in the NS5A and NS5B regions in Hepatitis C virus genotype 2 and response to sofosbuvir plus ribavirin therapy International conference

    Hayashi K., Ishigami M., Ishizu Y., Kazuya T., Honda T., Hirooka Y., Goto H.

    EASL2018  2018.4 

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    Event date: 2018.4

    Language:English   Presentation type:Poster presentation  

  52. Utility and limitation of non-invasive fibrosis markers for predicting the prognosis in biopsy-proven Japanese NAFLD patients International conference

    Ito T., Ishigami M., Ishizu Y., Kazuya T., Honda T., Hayashi K., Ishikawa T., Hirooka Y., Goto H.

    EASL2018  2018.4 

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    Event date: 2018.4

    Language:English   Presentation type:Poster presentation  

  53. Secreted ectodomain of SIGLEC-9 and MCP-1 ameliorate acute liver failure in rats by altering bone marrow macrophage polarity International conference

    Ito T., Ishigami M., Yamamoto A., Ishizu Y., Kazuya T., Honda T., Hayashi K., Ishikawa T., Hirooka Y., Goto H.

    EASL2018  2018.4 

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    Event date: 2018.4

    Language:English   Presentation type:Poster presentation  

  54. Prognostic factors related to post-progression survival in advanced hepatocellular carcinoma patients treated with sorafenib not eligible for second-line regorafenib treatment Teiji Kuzuya* 1, Masatoshi Ishigami1, Takanori Ito1, Yoji Ishizu1"

    Kuzuya T, Ishigami M, Ito T, Ishizu Y, Honda T, Hirooka Y

    ILCA2018  2018 

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    Event date: 2018

    Language:English   Presentation type:Poster presentation  

    Venue:London  

  55. Association between microbiome and hepatitis C virus-infected patients with hepatocellular carcinoma International conference

    Honda T, Ishigami M, Yamamoto K, Ito T, Ishizu Y, Kuzuya T, Hirooka Y

    ILCA2018  2018 

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    Event date: 2018

    Language:English   Presentation type:Poster presentation  

    Venue:London  

  56. Daclatasvir and asunaprevir treatment in patients with severe liver fibrosis by hepatitis C virus genotype 1b infection: Real-world data International conference

    Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ishikawa Tetsuya, Nakano Isao, Urano Fumihiro, Kumada Takashi, Yoshioka Kentaro, Goto Hidemi, Hirooka Yoshiki

    APASL  2017.11 

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    Event date: 2017.11

    Language:English   Presentation type:Poster presentation  

  57. 非B非C肝癌における肝発癌に関連する腸内細菌叢の検討

    本多隆

    JDDW2017  2017.10.12 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  58. B型慢性肝炎におけるインターフェロン治療効果とcoreI97L変異によるその後の肝炎沈静化の予測

    本多隆、石上雅敏、後藤秀実

    JDDW2017  2017.10.12 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  59. Core I97LとP79Qの変異はB型慢性肝炎患者において持続HBVDNA低値とHBs抗原消失に関与する

    本多 隆、石上雅敏、後藤秀実

    第53回日本肝臓学会総会  2017.6.8 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  60. The Impact of Hepatitis B Virus Infection on Sustained Virologic Response and HBV Reactivation in Patients with Chronic Hepatitis C who Treated by all-Oral Direct-Acting Antivirals Regimens International conference

    Hayashi K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hirooka Y, Goto H

    DDW2017  2017 

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    Event date: 2017

    Language:English   Presentation type:Poster presentation  

    Venue:Chicago  

  61. The Association Between Amino Acid Substitutions in the NS5A Region of Hepatitis C Virus and Development of Hepatocellular Carcinoma After Sustained Virological Response International conference

    Yashuda S, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, Hirooka Y, Goto H"

    DDW2017  2017 

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    Event date: 2017

    Language:English   Presentation type:Poster presentation  

    Venue:Chicago  

  62. B型慢性肝炎におけるインターフェロン治療効果とCoreI97L変異による治療効果の予測

    本多隆

    JDDW2016  2016.11.2 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  63. Relation between core mutations and HBVDNA, HBsAg decreasing rate in the patients with chronic hepatitis B International conference

    Takashi Honda

    APDDW2016  2016.11.2 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  64. Revisiting the prognosis after liver transplantation in HCV-positive patients-focus on HCV-unrelated complications International conference

    Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Hirooka Yoshiki, Goto Hidemi

    APASL2016  2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

  65. Treatment for elderly patients with hepatitis C Invited International conference

    Takashi Honda, Masatoshi Ishigami, Kazuhiko Hayashi, Hidemi Goto

    3rd International Monothematic Conference on Viral Hepatitis C   2016.9.29 

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Croatia  

  66. コリン欠乏高脂肪食によるNASHマウスモデルにおける分岐鎖アミノ酸投与による糖質、アミノ酸代謝の変化

    本多 隆、石上雅敏、山本健太、安藤祐資、安田 諭、伊藤隆徳、野村 彩、加藤幸一郎、新家卓郎、石津洋二、葛谷貞二、林 和彦、廣岡芳樹、石川哲也、中野功、後藤秀実

    第3回肝臓と糖尿病代謝研究会  2016.7.16 

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    Event date: 2016.7

    Language:Japanese  

  67. Efficacy of dual oral therapy with asunaprevir and daclatasvir for elderly patients with hepatitis C International conference

    Honda T, Ishigami M , Ishizu Y, Kuzuya T, Hayashi K, Hirooka Y, Goto H

    HCVmeeting2016  2016.7.7 

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    Event date: 2016.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  68. Core I97L mutation is associated with persistent low HBV DNA and HBsAg clearance in patients with chronic hepatitis B International conference

    Takashi Honda, Masatoshi Ishigami, Yoji Ishizu, Teiji Kuzuya, Kazuhiko Hayashi, Yoshiki Hirooka, Hidemi Goto

    DDW2016  2016.5.24 

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    Event date: 2016.5

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  69. B型慢性肝炎におけるcoreI97L変異とHBV DNA減少及びHBs抗原の消失に関する検討

    本多 隆、石上雅敏、後藤秀実

    第52回日本肝臓学会総会  2016.5.19 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (general)  

  70. HBs抗原消失がみられI97L変異の長期観察ができた症例の検討

    本多隆

    第101回日本消化器病学会総会  2016.4.23 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  71. B型慢性肝炎におけるcoreI97L変異による持続HBV DNA低値ALT正常及びHBs抗原消失の予測

    本多 隆、石上雅敏、後藤秀実

    第41回日本肝臓学会西部会  2015.12.4 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  72. 高齢者C型慢性肝炎におけるDaclatasvir /Asunaprevir併用療法の早期反応と治療効果

    本多 隆、石上雅敏、安藤祐資、安田 諭、伊藤隆徳、川口 彩、加藤幸一郎、新家卓郎、今井則博、阿知波宏一、石津洋二、葛谷貞二、林 和彦、石川哲也、中野 功、後藤秀実

    第41回日本肝臓学会西部会  2015.12.4 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  73. Early response and efficacy of dual oral therapy with asunaprevir and daclatasvir for elderly patients with hepatitis C International conference

    Takashi Honda, Masatoshi Ishigami, Yoji Ishizu, Teiji Kuzuya, Kazuhiko Hayashi, Yoshiki Hirooka, Hidemi Goto

    AASLD2015  2015.11.15 

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    Event date: 2015.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  74. B型慢性肝炎におけるHBVDNA及びHBs抗原減少に関与するウイルス遺伝子変異の検討

    本多 隆、石上雅敏、後藤秀実

    JDDW2015  2015.10.8 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  75. DSS colitis has tumorinogenesis and fibrogenesis in choline-deficiency and high-fat diet induced NASH mouse model International conference

    Achiwa Koichi, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Hirooka Yoshiki, Goto Hidemi

    AASLD2015  2015.10 

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    Event date: 2015.10

    Language:English  

  76. The relationship between the fever within 6 weeks after the start of sorafenib therapy and the outcome for patients with advanced hepatocellular carcinoma International conference

    Kuzuya Teiji, Ishigami Masatoshi, Ishizu Yoji, Honda Takashi, Hayashi Kazuhiko, Goto Hidemi

    AASLD2015  2015.10 

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

  77. A comparison of direct sequencing and PCR-invader assay for the detection of NS5A Y93H mutation and response to daclatasvir and asunaprevir therapy in patients with hepatitis C virus genotype 1b International conference

    Hayashi Kazuhiko, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hirooka Yoshiki, Goto Hidemi

    AASLD2015  2015.10 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (general)  

  78. コリン欠乏高脂肪食による高血糖を伴わないNASHマウスモデルにおける脂質、分岐鎖アミノ酸代謝の検討

    本多 隆、石上雅敏、伊藤隆徳、安田 諭、川口 彩、加藤幸一郎、新家卓郎、今井則博、阿知波宏一、石津洋二、葛谷貞二、林 和彦、中野 功、石川哲也、片野義明、後藤秀実

    第2回肝臓と糖尿病代謝研究会  2015.5.23 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:下関   Country:Japan  

  79. 高齢者C型肝炎におけるDaclatasvir・Asunaprevir併用療法の治療早期の効果

    本多 隆、石上雅敏、新家卓郎、今井則博、阿知波宏一、荒川恭宏、山田恵一、中野 聡、石津洋二、葛谷貞二、林 和彦、中野 功、石川哲也、片野義明、後藤秀実

    第51回日本肝臓学会総会  2015.5.21 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:熊本   Country:Japan  

  80. B型慢性肝炎におけるcoreI97変異がその後の経過に及ぼす影響

    本多 隆、石上雅敏、川口 彩、加藤幸一郎、新家卓郎、今井則博、阿知波宏一、山田恵一、石津洋二、葛谷貞二、林 和彦、石川哲也、中野 功、後藤秀実

    第101回日本消化器病学会総会  2015.4.23 

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    Event date: 2015.4

    Language:Japanese   Presentation type:Oral presentation (general)  

  81. The Prevalence of Naturally Occurring Resistance Mutations Against Direct Acting Antivirals in Patients With Hepatitis C Virus Genotype 1b and Response to Interferon Based Therapy International conference

    Hayashi Kazuhiko, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Katano Yoshiaki, Goto Hidemi

    DDW2015  2015.4 

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    Event date: 2015.4

    Language:English   Presentation type:Poster presentation  

  82. B型肝炎における経過予測及びHBs抗原消失に関与するウイルス遺伝子変異

    本多 隆、石上雅敏、後藤秀実

    第40回日本肝臓学会東部会  2014.11.27 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  83. Oral supplementation of BCAA alleviates hepatic steatosis and liver injury associated with NASH International conference

    Takashi Honda, Masatoshi Ishigami, Fangqiong Luo, Yoji Ishizu, Teiji Kuzuya, Kazuhiko Hayashi, Yoshiharu Shimomura, and Hidemi Goto

    AASLD2014  2014.11.9 

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    Event date: 2014.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  84. Reactivation of hepatitis B virus in patients without hepatitis B surface antigen treated with immunosuppressive or chemotherapy International conference

    Hayashi Kazuhiko, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Katano Yoshiaki, Hirooka Yoshiki, Goto Hidemi

    APASL2014  2014.11 

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    Event date: 2014.11

    Language:English   Presentation type:Poster presentation  

  85. 高齢者C型慢性肝炎におけるPegIFN・Ribavirin・Simeprevir3剤併用療法の治療効果

    本多 隆、石上雅敏、加藤幸一郎、新家卓郎、今井則博、阿知波宏一、荒川恭宏、山田恵一、石津洋二、葛谷貞二、林 和彦、中野 功、石川哲也、後藤秀実

    JDDW2014  2014.10.24 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  86. C型慢性肝炎難治例におけるPegIFN・Ribavirin・Telaprevir3剤併用療法の治療効果

    本多 隆、石上雅敏、新家卓郎、今井則博、阿知波宏一、荒川恭宏、山田恵一、中野 聡、石津洋二、葛谷貞二、林 和彦、中野 功、石川哲也、片野義明、後藤秀実

    第50 回日本肝臓学会総会  2014.5.29 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  87. 分岐鎖アミノ酸によるNASHマウスモデルにおける肝脂肪抑制効果

    本多 隆、石上雅敏、新家卓郎、今井則博、阿知波宏一、荒川恭宏、山田恵一、中野 聡、石津洋二、葛谷貞二、林 和彦、石川哲也、中野 功、後藤秀実

    第100回日本消化器病学会総会  2014.4.23 

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    Event date: 2014.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  88. 高齢者C型慢性肝炎に対するPegIFN・Ribavirin・Telaprevir3剤併用療法の治療効果

    本多 隆、片野義明、後藤秀実

    JDDW2013  2013.10.10 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  89. The disappearance or decrease of tumor stain on contrast enhanced CT images after 2 weeks of sorafenib treatment predicts sorafenib efficacy in patients with advanced hepatocellular carcinoma International conference

    Kuzuya Teiji, Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Goto Hidemi

    AASLD2013  2013.10 

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    Event date: 2013.10

    Language:English   Presentation type:Poster presentation  

  90. Prevalence of resistance mutations against NS3 protease inhibitors in patients with hepatitis C virus genotype 1b and response to telaprevir plus pegylated-interferon-alpha 2b and ribavirin combination therapy International conference

    Hayashi Kazuhiko, Katano Yoshiaki, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ishigami Masatoshi, Goto Hidemi

    AASLD2013  2013.10 

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    Event date: 2013.10

    Language:English   Presentation type:Poster presentation  

  91. HBe抗体陽性B型慢性肝炎における経過予測に必要なウイルス遺伝子変異の検討

    本多 隆、片野義明、後藤秀実

    第49回日本肝臓学会総会  2013.6.7 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  92. Analysis of Late Onset (>= 3 Postoperative Months) Liver Dysfunction after Liver Transplantation. International conference

    Ishigami Masatoshi, Ishizu Yoji, Onishi Yasuharu, Kamei Hideya, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Katano Yoshiaki, Ogura Yasuhiro, Goto Hidemi

    ILTS2013  2013.6 

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    Event date: 2013.6

    Language:English   Presentation type:Poster presentation  

  93. Effect of combination therapy peginterferon alfa-2b and ribavirin on prevention of hepatocellular carcinoma in patients with chronic hepatitis C and normal aminotransferase levels International conference

    Takashi Honda, Yoshiaki Katano, Satoshi Nakano, Yoji Ishizu, Teiji Kuzuya T, Kazuhiko Hayashi, Masatoshi Ishigami, Hidemi Goto

    DDW2013  2013.5.18 

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    Event date: 2013.5

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  94. Real-Time Tissue Elastography for the Assessment of Liver Fibrosis in Patients With Chronic Hepatitis C and Correlation With Response to Pegylated-Interferon-Alpha 2B and Ribavirin Combination Therapy International conference

    Hayashi Kazuhiko, Katano Yoshiaki, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishigami Masatoshi, Goto Hidemi

    DDW2013  2013.5 

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    Event date: 2013.5

    Language:English   Presentation type:Poster presentation  

  95. C型慢性肝炎難治例におけるペグインターフェロン・リバビリン併用療法の治療効果と発癌抑制効果

    本多 隆、片野義明、後藤秀実

    第99回日本消化器病学会総会  2013.3.21 

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    Event date: 2013.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:鹿児島   Country:Japan  

  96. Reactivation of HBV by anti-tumor necrosis factor-alpha therapy in a HBs antigen-negative patient with inflammatory bowel disease International conference

    Hayashi Kazuhiko, Katano Yoshiaki, Kuzuya Teiji, Honda Takashi, Ishigami Masatoshi, Itoh Akihiro, Omiya Naoki, Hirooka Yoshiki, Ando Takafumi, Goto Hidemi

    APASL2012  2012.12 

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    Event date: 2012.12

    Language:English   Presentation type:Poster presentation  

  97. Effect of combination therapy peginterferon alfa-2b and ribavirin on prevention of hepatocellular carcinoma in advanced chronic hepatitis C International conference

    Honda T, Katano Y, Kuzuya T, Hayashi K, Ishigami M, Nakano I, Toyoda H, Kumada T, Yoshioka K, Goto H

    AASLD2012  2012.11.13 

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    Event date: 2012.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  98. 高齢者C型慢性肝炎におけるペグインターフェロン/リバビリン併用療法の治療効果と発癌抑制効果

    本多 隆、片野義明、後藤秀実

    第16回日本肝臓学会大会  2012.10.10 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  99. C型肝炎線維化進展例におけるペグインターフェロン/リバビリン併用療法の発癌抑制効果

    本多 隆、片野義明、中野 聡、増田寛子、及部祐加子、石津洋二、葛谷貞二、舘 佳彦、林 和彦、石上雅敏、中野 功、石川哲也、後藤秀実

    第48回日本肝臓学会総会  2012.6.8 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:金沢   Country:Japan  

  100. A Case of HBeAg Serocoversion with Emerged Mutation of rt M 204 I/V in the Patients with Hepatitis B and HIV International conference

    Honda T, Katano Y, Kuzuya T, Tachi Y, Hayashi K, Ishigami M, Nakano I, Goto H

    APASL2012  2012.2.17 

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    Event date: 2012.2

    Language:English   Presentation type:Poster presentation  

    Country:Taiwan, Province of China  

  101. HIV、HBV重複感染例でHBVに対するラミブジン耐性株の出現後HBe抗体陽性が持続し肝炎が沈静化した1例

    本多 隆, 片野義明, 中野 聡, 増田寛子, 及部祐加子, 石津洋二, 葛谷貞二, 舘 佳彦, 林 和彦, 石上雅敏, 中野 功, 石川哲也, 後藤秀実

    第39回日本肝臓学会西部会  2011.12.10 

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    Event date: 2011.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:岡山   Country:Japan  

  102. Efficacy of Combination Therapy Peginterferon Alfa-2b and Rebavirin on Prevention of Hepatocellular Carcinoma in order Patients with Chronic Hepatitis C. International conference

    Honda T, Katano Y, Kuzuya T, Tachi Y, Hayashi K, Ishigami M, Nakano I, Goto H

    AASLD2011  2011.11.6 

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    Event date: 2011.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  103. CLINICAL SIGNIFICANCE OF SERUM HEPATITIS B CORE RELATED ANTIGEN (HBCRAG) IN CHRONIC HBV-INFECTED PATIENTS International conference

    Ishigami Masatoshi, Katano Yoshiaki, Hayashi Kazuhiko, Honda Takashi, Tachi Yoshihiko, Nakano Isao, Goto Hidemi

    ILTS2010  2011.10 

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    Event date: 2011.10

    Language:English   Presentation type:Poster presentation  

  104. THE SUBSTITUTIONS IN AMINO ACID 70 IN THE HEPATITIS C VIRUS GENOTYPE 1B CORE REGION CORRELATE WITH LIVER STEATOSIS AND INSULIN RESISTANCE IN NON-OBESE PATIENTS WITH CHRONIC HEPATITIS C International conference

    Tachi Yoshihiko, Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Katano Yoshiaki, Kuzuya Teiji, Goto Hidemi

    AASLD2011  2011.10 

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    Event date: 2011.10

    Language:English   Presentation type:Poster presentation  

  105. ASSOCIATION BETWEEN A SINGLE-NUCLEOTIDE POLYMORPHISM OF INTERLEUKIN 28B AND MUTATIONS IN THE NS5A REGION OF HEPATITIS C VIRUS GENOTYPE 2 WITH RESPONSE TO PEGYLATED-INTERFERON-ALPHA 2B AND RIBAVIRIN COMBINATION THERAPY International conference

    Hayashi Kazuhiko, Katano Yoshiaki, Honda Takashi, Ishigami Masatoshi, Goto Hidemi, Toyoda Hidenori, Kumada Takashi

    AASLD2011  2011.10 

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    Event date: 2011.10

    Language:English   Presentation type:Poster presentation  

  106. 高齢者C型慢性肝炎におけるペグインターフェロン/リバビリン併用療法の発癌抑制効果

    本多隆, 片野義明, 中野聡, 増田寛子, 及部祐加子, 小野幸矢, 石津洋二, 土居崎正雄, 葛谷貞二, 舘佳彦, 林和彦, 石上雅敏, 中野功, 石川哲也, 後藤秀実

    DDW-Japan2011(消化器病)  2011.9 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡   Country:Japan  

  107. ペグインターフェロン、リバビリン併用療法における凝固因子の検討

    本多 隆、片野義明、増田寛子、及部祐加子、小野幸矢、石津洋二、清水潤一、土居崎正雄、舘 佳彦、林 和彦、石上雅敏、中野 功、石川哲也、後藤秀実

    第47回日本肝臓学会総会  2011.6.3 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  108. Additional Effect of Ribavirn During Peginterferon and Ribavirin Combination Therapy in Coagulation Factor International conference

    Honda T,Katano Y, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Goto H.

    DDW2011  2011.5.8 

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    Event date: 2011.5

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  109. 高齢者C型慢性肝炎に対するペグインターフェロン/リバビリン併用療法の効果

    本多 隆、片野義明、後藤秀実

    日本消化器病学会東海支部第113回例会  2010.11.27 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  110. ASSOCIATION BETWEEN A SINGLE-NUCLEOTIDE POLYMORPHISM OF INTERLEUKIN 28B AND MUTATIONS IN THE CORE AND NS5A REGION OF HEPATITIS C VIRUS GENOTYPE 1B WITH RESPONSE TO PEGYLATED-INTERFERON-ALPHA 2B AND RIBAVIRIN COMBINATION THERAPY International conference

    Hayashi Kazuhiko, Katano Yoshiaki, Honda Takashi, Ishigami Masatoshi, Nakano Isao, Goto Hidemi

    AASLD2010  2010.10 

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    Event date: 2010.10

    Language:English   Presentation type:Poster presentation  

  111. THE ROLE OF SUBSTITUTIONS IN THE CORE AND NS5A REGION OF HEPATITIS C VIRUS GENOTYPE 1B ON RESPONSIVENESS TO PEGYLATED INTERFERON AND RIBAVIRIN COMBINATION THERAPY International conference

    Katano Y., Ishigami M., Nakano I., Hayashi K., Honda T., Goto H.

    EASL2009  2009 

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    Event date: 2009

    Language:English   Presentation type:Poster presentation  

  112. SHORT DURATION THERAPY OF PEGYLATED INTERFERON ALFA-2B PLUS RIBAVIRIN FOR HCV GENOTYPE 2 PATIENTS International conference

    Katano Yoshiaki, Ishigami Mosatashi, Nakano Isao, Hayashi Kazuhiko, Honda Takashi, Goto Hidemi

    AASLD2008  2008.10 

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    Event date: 2008.10

    Language:English   Presentation type:Poster presentation  

  113. Dramatic decrease in bleeding events in hemophilia A patient with inhibitor during and after receiving anti-HCV treatment with ribavirin International conference

    Yamamoto K., Honda T., Toyoda H., Matsushita T., Goto H., Takamatsu J.

    ILTS2008  2008.7 

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    Event date: 2008.7

    Language:English   Presentation type:Poster presentation  

  114. ASSESSMENT OF RELATIONSHIP BETWEEN SPLEEN VOLUME AND PLATELET COUNT AFTER LIVING DONOR LIVER TRANSPLANTATION IN JAPANESE ADULT PATIENTS International conference

    Ishizu Yoji, Ishigami Masatoshi, Nishino Masamichi, Honda Takashi, Hayashi Kazuhiko, Kamei Hideya, Nakamura Taro, Katano Yoshiaki, Kiuchi Tetsuya

    ILTS2008  2008.7 

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    Event date: 2008.7

    Language:English   Presentation type:Poster presentation  

  115. Genotype2型C型慢性肝炎に対するPegIFNα-2b/Ribavirin併用療法(短期投与の検討)

    第44回日本肝臓学会総会  2008.6.6 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  116. 高齢者C型慢性肝炎におけるペグインターフェロン・リバビリン併用療法の効果

    第94回日本消化器病学会総会  2008.5.9 

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    Event date: 2008.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  117. Efficacy of ribavirin plus pedinterferon-alfa in elderly patients with chronic hepatitis C International conference

    Honda T, Katano Y, Doizaki K, , Hayashi K, Ishigami M, Nakano I, Urano F, Yoshioka K, Toyoda H, Kumada T, Goto H

    EASL2008  2008.4.24 

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    Event date: 2008.4

    Language:English   Presentation type:Poster presentation  

    Country:Italy  

  118. 凝固障害患者(主に血友病)におけるC型慢性肝炎に対するペグインターフェロンとリバビリン併用療法の効果

    第37回日本肝臓学会西部会  2007.12.8 

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    Event date: 2007.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  119. C型慢性肝炎に対するペグインターフェロン・ リバビリン併用療法無効例の特徴

    2007.10.18 

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    Event date: 2007.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  120. Combination therapy with pegylated interferon ALFA-2B and ribavirin for patients with chronic hepatitis C and normal aminotransferase levels International conference

    Kotano Yoshiaki, Ishigami Mosatoshi, Nakano Isao, Hayashi Kozuhiko, Honda Takashi, Goto Hidemi

    AASLD2007  2007.10 

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    Event date: 2007.10

    Language:English   Presentation type:Poster presentation  

  121. Genotype2型C型慢性肝炎に対するPegIFNα-2b/Ribavirin併用療法(少量投与の検討)

    本多 隆、片野 義明、中野 功、石上 雅敏、林 和彦、竹田 泰史、森井 正哉、西野 正路、後藤 新太郎、舘 佳彦、葛谷 貞二、岩田 浩史、土居崎 正雄、後藤 秀実

    第43回日本肝臓学会総会  2007.5.31 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  122. 高齢者C型肝炎に対するペグインターフェロン・リバビリン併用療法

    本多隆、片野義明、後藤秀実

    第93回日本消化器病学会総会  2007.4.19 

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    Event date: 2007.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  123. Efficacy of ribavirin plus interferon-alfa in elderly patients with chronic hepatitis C International conference

    Honda T, Katano Y, Urano F, Hayashi K, Ishigami M, Nakano I, Yoshioka Y, Toyoda H, Kumada T, Goto H

    EASL2007  2007.4.13 

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    Event date: 2007.4

    Language:English   Presentation type:Poster presentation  

    Country:Spain  

  124. Characteristic of the nonresponder to pegylated-interferon and ribavirin combination therapy in patients with hepatitis C virus genotype 1 infection International conference

    Honda T, Katano Y, Nakano I, Ishigami M, Hayashi K, Yoshioka K, Kumada T, Toyoda H, Goto H

    APASL2007  2007.3.29 

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    Event date: 2007.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  125. ADDITIONAL EFFECT OF RIBAVIRIN DURING PEGINTERFERON AND RIBAVIRIN COMBINATION THERAPY International conference

    Honda T, Katano Y, Toyoda H, Kumada T, Hayashi K, Ishigami M, Nakano I, Yamamoto K, Takamatsu J and Goto H

    AASLD2007 Single Topic Conference  2007.3.2 

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    Event date: 2007.3

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  126. Efficacy of ribavirin plus interferon-alfa in elderly patients with chronic hepatitis C International conference

    Honda T., Katano Y., Urano F., Hayashi K., Ishigami M., Nakano I., Yoshioka K., Toyoda H., Kumada T., Goto H.

    EASL2007  2007 

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    Event date: 2007

    Language:English   Presentation type:Poster presentation  

  127. C型慢性肝炎に対するペグインターフェロン・ リバビリン併用療法(無効例の検討)

    DDW-Japan2006(肝臓)  2006.10 

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    Event date: 2006.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  128. ALT正常C型慢性肝炎に対するペグインターフェロン・リバビリン併用療法

    本多隆、片野義明、後藤秀実

    第41回日本肝臓学会総会  2006.5 

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    Event date: 2006.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  129. Comparison of clinical and virological feature between genotype A and genotype C among patients with acute hepatitis B in Japan International conference

    Takeda Yasushi, Takano Yoshiaki, Hayashi Kazuhiko, Ishigami Masatoshi, Honda Takashi, Goto Hidemi

    APASL2006  2006.3 

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    Event date: 2006.3

    Language:English   Presentation type:Poster presentation  

  130. ALT正常C型慢性肝炎に対するインターフェロン・リバビリン併用療法のウイルス学的効果

    第36回日本肝臓学会西部会  2005.11.25 

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    Event date: 2005.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    本多隆、片野義明、中野 功、石上雅敏、林 和彦、森井正哉、西野正路、竹田泰史、仲島さより、村山 睦、石黒裕規、葛谷貞二、岩田浩史、後藤秀実

  131. Anti-HCV agent, ribavirin, decreases events of bleeding in hemophilia patients, possibly by elevating the clotting activity of factor VII. International conference

    Yamamoto K, Honda T, Suzuki S, Toyoda H, Matsushita T, Kojima T, Goto H, Takamatsu J

    ASH2005  2005.11.16 

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    Event date: 2005.11

    Language:English   Presentation type:Poster presentation  

  132. 高齢者C型慢性肝炎におけるインターフェロンとリバビリン併用療法の効果

    本多隆、片野義明、後藤秀実

    Digestive Disease Week-Japan 2005  2005.10 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  133. HBV genotype distribution differs in acute hepatitis from chronic hepatitis in Japan International conference

    Takeda Y, Katano Y, Hayashi K, Honda T, Goto H

    AMERICAN JOURNAL OF GASTROENTEROLOGY  2005.9 

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    Event date: 2005.9

    Language:English   Presentation type:Poster presentation  

  134. C型慢性肝炎に対するインターフェロンリバビリン併用療法におけるNon-responderの検討

    本多隆、片野義明、石黒裕規、仲島さより、村山睦、竹田泰史、小田切英樹、西野正路、山田晋太郎、佐々木論実彦、横崎正一、石上雅敏、長野健一、中野功、矢野元義、後藤秀実

    第41回日本肝臓学会総会  2005.6 

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    Event date: 2005.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  135. JISscore,CLIPsore及びTokyo scoreを用いた肝細胞癌治療法別の予後

    第41回日本肝臓学会総会  2005.6 

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    Event date: 2005.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

    本多隆、片野義明、矢野元義、中野功、長野健一、石上雅敏、横崎正一、佐々木論実彦、山田晋太郎、西野正路、小田切英樹、竹田泰史、仲島さより、村山睦、石黒裕規、後藤秀実

  136. JISscore及びCLIPscoreを用いた肝細胞癌治療法別の予後

    本多隆、片野義明、後藤秀実

    日本消化器病学会東海支部第101回例会  2005.1 

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    Event date: 2005.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  137. C型慢性肝炎に対するインターフェロン・リバビリン併用療法後のインターフェロン単独療法追加による著効率の向上

    第8回日本肝臓学会大会  2004.10 

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    Event date: 2004.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

    本多隆、片野義明、石黒裕規、仲島さより、村山睦、竹田泰史、小田切英樹、水谷哲也、佐々木論実彦、横崎正一、石上雅敏、長野健一、中野功、矢野元義、吉岡健太郎、後藤秀実

  138. C型慢性肝炎に対するインターフェロン・リバビリン併用療法におけるウイルス学、生化学的効果の検討

    2004.6 

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    Event date: 2004.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

    本多隆、片野義明、石黒裕規、仲島さより、村山睦、竹田泰史、小田切英樹、水谷哲也、佐々木論実彦、横崎正一、石上雅敏、長野健一、中野功、矢野元義、吉岡健太郎、後藤秀実

  139. 高齢者C型慢性肝炎におけるインターフェロンとリバビリン併用療法の検討

    本多隆、片野義明、後藤秀実

    第90回日本消化器病学会総会  2004.4 

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    Event date: 2004.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  140. 血友病患者におけるoccult HBV infectionの頻度とその臨床的意義

    第7回日本肝臓学会大会  2003.10.16 

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    Event date: 2003.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    本多隆、豊田秀徳、石黒裕規、仲島さより、竹田泰史、小田切英樹、林和彦、横崎正一、長野健一、片野義明、中野功、高松純樹、後藤秀実

  141. 急性肝不全および肝硬変での分岐鎖アミノ酸代謝の違い

    第39回日本肝臓学会総会  2003.5.22 

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    Event date: 2003.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    本多隆、下村吉治、福田吉秀、中野功、片野義明、横崎正一、林和彦、清水秀幸、清水富紀子、内藤岳人、小田切英樹、竹田泰史、仲島さより、村山睦、石黒裕規

  142. Differences in branched-chain amino acid catabolism between acute liver failure and liver cirrhosis in rats International conference

    Honda T., Shimomura. Y., Fukuda Y. Nakano I., Katano Y. Murakami T., Nagasaki M.

    Experimental Biology 2003  2003.4.13 

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    Event date: 2003.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  143. Association of mutations in two PKR binding domains of hepatitis C virus genotype 3a and viral loads International conference

    Fukuda Y, Katano Y, Toyoda H, Yokozaki S, Hayashi K, Naito T, Shimizu H, Honda T, Otakiri H, Takeda Y, Nakashima S, Ishiguro H, Nakano I

    EASL2003  2003.4 

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    Event date: 2003.4

    Language:English   Presentation type:Poster presentation  

  144. Responses to retraining of glucose uptake in rat skeletal muscle International conference

    Nagasiaki M, Shimomura Y, Bajotto G, Honda T, Oshida Y, Sato Y

    FASEB JOURNAL  2003.3.17 

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    Event date: 2003.3

    Language:English   Presentation type:Poster presentation  

  145. Comparison between iron reduction therapy versus vitamin E treatment of chronic hepatitis C who previously failed interferon therapy International conference

    Hayashi K, Fukuda Y, Nakano I, Katano Y, Toyoda H, Yokozaki S, Naito T, Shimizu H, Shimizu Y, Honda T, Otakiri H

    APASL2002  2002 

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    Event date: 2002

    Language:English   Presentation type:Poster presentation  

  146. Immunologic dynamics in a patient with tandem acute infection by HCV and HBV. International conference

    Fukuda Y, Nakano I, Katano Y, Nagano K, Yokozaki S, Hayashi K, Shimizu H, Shimizu F, Naito T, Honda T, Shizu Y, Hayakawa T

    EASL2001  2001.10 

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    Event date: 2001.10

    Language:English   Presentation type:Poster presentation  

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. HBV cccDNAの産生と維持に関わるウイルスおよび宿主因子の探索

    2022.4 - 2025.3

    日本医療研究開発機構(AMED)  肝炎等克服実用化研究事業 B型肝炎創薬実用化等研究事業 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\10000000

  2. B型肝炎ウイルス構造解析による薬剤応答性の評価と新規治療薬開発に関する研究

    2013.10 - 2016.3

    厚生労働省  科学技術振興調整費 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. HBs抗原陰性化に関わるB型肝炎ウイルス変異と腸内細菌叢が及ぼす免疫応答の解明

    Grant number:20K08382  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    本多 隆

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  2. サルコペニア患者に対する腸内細菌叢への介入による効果的な運動療法の開発

    Grant number:21K11261  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    石津 洋二, 本多 隆, 梅垣 宏行, 山本 健太

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    Authorship:Coinvestigator(s) 

    サルコペニアに対する治療は運動療法であるが、十分な効果を得られないことが多い。近年、腸内細菌が産生する短鎖脂肪酸が骨格筋と関係している事が明らかになった。短鎖脂肪酸は腸内環境を整えることで炎症を抑え、それにより骨格筋の分解を抑える働きを持つ。さらに筋肉におけるエネルギー代謝にも関連し、運動時の易疲労性に対し予防的に働く。以上のことから、運動療法に短鎖脂肪酸産生を増加させるような腸内細菌叢への介入を加えることで、運動療法の効果を増強できるのではないかと考えた。そこで本研究は、サルコペニアに対し、腸内細菌叢への介入による効果的な運動療法を開発することを目的とする。

  3. 炎症性腸疾患における新規粘膜関連細菌叢検出法を用いた腸粘膜炎症プロファイルの作成

    Grant number:20K07801  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    中村 正直

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  4. Studies on immunity and anti-inflammatory mechanisms regulated by diet and intestinal microenvironment

    Grant number:19H04042  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  5. Gut microbiota and therapeutic intervention in non-B,non-C hepatocellular carcinoma

    Grant number:17K09418  2017.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    HONDA TAKASHI

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    Authorship:Principal investigator  Grant type:Collaborative (industry/university)

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  6. NASHにおけるアミノ酸代謝と肝脂肪改善及び進展抑制のメカニズム

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

    本多 隆

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    Authorship:Principal investigator 

  7. 新規蛋白ナオフェンはエンドドキシンによる肝障害を抑制する新たな因子となりうるか

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(C)

    馮 国剛

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    Authorship:Coinvestigator(s) 

    LPS による肝障害において肝細胞アポトーシスの発生と新規物質naofen およびその結合物質であるannexinI との関連を調べ、エンドトキシン血症の治療に際して、新たなターゲットを検索する。

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Industrial property rights 1

  1. B型肝炎患者の臨床経過を予測する方法

    東海国立大学機構

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    Date applied:2016.6

    Announcement no:2017-216939  Date announced:2017.12

    Country of applicant:Domestic   Country of acquisition:Domestic