名古屋大学医学部准教授

2007.4

名古屋大学医学部助教授

2004.5

名古屋大学大学院医学系研究科担当

2004.5

名古屋大学大学院医学系研究科非常勤講師

2003.4 - 2004.3

名古屋刑務所   医務部医療課   医師（法務技官）

2003.1 - 2004.4

名古屋大学医学部附属病院医員

2002.11 - 2002.12

愛知県総合保健センター循環器診断部長

2000.5 - 2001.3

愛知県総合保健センター総合診断部診断第一室長

2000.4

愛知県総合保健センター循環器診断部循環器診断室長

1999.7 - 2000.3

名古屋大学医学部附属病院第一内科客員研究者

1998.9 - 2004.4

米国ボストン大学医学部心筋研究所Research Associate

1998.4 - 1998.8

米国ボストン大学医学部心筋研究所Research Fellow

1996.12 - 1998.3

米国ハーバード大学医学部心血管研究所Postdoctoral Fellow

1996.4 - 1996.11

JR東海総合病院循環器科副医長

1993.9 - 1996.2

名古屋第二赤十字病院循環器科医師

1988.4 - 1993.8

新城市民病院循環器科医師

1987.7 - 1988.3

名古屋第二赤十字病院循環器科医師

1987.5 - 1987.7

名古屋第二赤十字病院研修医

1985.5 - 1987.4

The Japanese Heart Failure Society

2010.4

The Japanese Society of Internal Medicine

International Society for Heart Research (Japanese Section)

2003.10

日本臨床検査学教育協議会 科目別分科会   生体検査学（会長）

2013.8 - 2017.8

博物館運営委員会   委員  

2018.4 - 2020.3   

学部カリキュラム検討WG（講座内）   委員（講座主任）  

2016.4 - 2018.3   

臨地実習委員会（講座内）   委員（講座主任）  

2016.4 - 2018.3   

広報・オープンキャンパス委員会（講座内）   委員（講座主任）  

2016.4 - 2018.3   

基礎セミナー部会   委員（講義担当者）  

2015.4 - 2016.3   

タイ保健医療体験入門プログラムWG   委員  

2015.3 - 2016.3   

名古屋ー延世大学間学術研究交流会（講座内）   委員  

2014.4 - 2016.3   

将来構想検討WG（講座内）   委員  

2013.4 - 2020.3   

環境報告書作成検討WG   委員  

2013.4 - 2016.3   

将来構想委員会 教育WG   委員  

2012.12 - 2016.3   

予算委員会   委員  

2012.4 - 2016.3   

整備計画委員会保健学部会   委員  

2012.4 - 2016.3   

倫理委員会予備審査会（講座内）   委員（講座主任）  

2010.4 - 2018.3   

研究助成委員会   委員  

2010.4 - 2016.3   

総合医学教育センター運営委員会   委員  

2010.4 - 2016.3   

大幸地区安全衛生委員会（衛生管理者）   衛生管理者  

2006.4 - 2016.3   

Surgical ablation of whitened interscapular brown fat ameliorates cardiac pathology in salt-loaded metabolic syndrome rats Reviewed

Komatsu Y, Aoyama K, Yoneda M, Ito S, Sano Y, Kawai Y, Cui X, Yamada Y, Furukawa N, Ikeda K, Nagata K

Annals of the New York Academy of Sciences   Vol. 1492 ( 1 ) page： 11 - 26   2021.5

The prebiotic fiber inulin ameliorates cardiac, adipose tissue, and hepatic pathology but exacerbates hypertriglyceridemia in rats with metabolic syndrome Reviewed

Komatsu Y, Aoyama K, Yoneda M, Ashikawa S, Nakano S, Kawai Y, Cui X, Furukawa N, Ikeda K, Nagata K

American Journal of Physiology Heart and Circulatory Physiology   Vol. 320 ( 1 ) page： H281-H295   2021.1

Alleviation of salt-induced exacerbation of cardiac, renal, and visceral fat pathology in rats with metabolic syndrome by surgical removal of subcutaneous fat Reviewed

Aoyama K, Komatsu Y, Yoneda M, Nakano S, Ashikawa S, Kawai Y, Cui X, Ikeda K, Nagata K

Nutrition & Diabetes   Vol. 10 ( 1 ) page： 28   2020.8

次世代リーダーを育成するための臨床検査技師教育のあるべき姿とそれに向けた取組み―国立大学の立場から Invited

永田浩三

臨床検査技師教育   Vol. 11 ( 1 ) page： 73-77   2019.3

Overexpression of collagen type III in injured myocardium prevents cardiac systolic dysfunction by changing the balance of collagen distribution Reviewed

Uchinaka A, Yoshida M, Tanaka K, Hamada Y, Mori S, Maeno Y, Miyagawa S, Sawa Y, Nagata K, Yamamoto H, Kawaguchi N

The Journal of Thoracic and Cardiovascular Surgery   Vol. 156 ( 1 ) page： 217-226   2018.7

Effects of ramelteon on cardiac injury and adipose tissue pathology in rats with metabolic syndrome Reviewed

Uchinaka A, Kawashima Y, Sano Y, Ito S, Sano Y, Nagasawa K, Matsuura N, Yoneda M, Yamada Y, Murohara T, Nagata K

Annals of the New York Academy of Sciences   Vol. 1421 ( 1 ) page： 73-87   2018.6

Anti-inflammatory effects of heat-killed Lactobacillus plantarum L-137 on cardiac and adipose tissue in rats with metabolic syndrome Reviewed

Uchinaka A, Azuma N, Mizumoto H, Nakano S, Minamiya M, Yoneda M, Aoyama K, Komatsu Y, Yamada Y, Murohara T, Nagata K

Scientific Reports   Vol. 8 ( 1 ) page： 8156   2018.5

Evaluation of dermal wound healing activity of synthetic peptide SVVYGLR Reviewed

Uchinaka A, Kawaguchi N, Ban T, Hamada Y, Mori S, Maeno Y, Sawa Y, Nagata K, Yamamoto H

Biochemical and Biophysical Research Communications   Vol. 491 ( 3 ) page： 714-720   2017.9

Atorvastatin reduces cardiac and adipose tissue inflammation in rats with metabolic syndrome Reviewed

Yamada Y, Takeuchi S, Yoneda M, Ito S, Sano Y, Nagasawa K, Matsuura N, Uchinaka A, Murohara T, Nagata K

International Journal of Cardiology   Vol. 240   page： 332-338   2017.8

Effects of mTOR inhibition on cardiac and adipose tissue pathology and glucose metabolism in rats with metabolic syndrome Reviewed

Uchinaka A, Yoneda M, Yamada Y, Murohara T, Nagata K

Pharmacology Research & Perspectives   Vol. 5 ( 4 ) page： e00331   2017.8

Laminin α2-secreting fibroblasts enhance the therapeutic effect of skeletal myoblast sheets Reviewed

Uchinaka A, Tasaka K, Mizuno Y, Maeno Y, Ban T, Mori S, Hamada Y, Miyagawa S, Saito A, Sawa Y, Matsuura N, Nagata K, Yamamoto H, Kawaguchi N

European Journal of Cardio-Thoracic Surgery   Vol. 51 ( 3 ) page： 457-464   2017.5

Effects of various types of anesthesia on hemodynamics, cardiac function, and glucose and lipid metabolism in rats Reviewed

Sano Y, Ito S, Yoneda M, Nagasawa K, Matsuura N, Yamada Y, Uchinaka A, Bando YK, Murohara T, Nagata K

American Journal of Physiology Heart and Circulatory Physiology   Vol. 311 ( 6 ) page： H1360-H1366   2016.12

Highly purified eicosapentaenoic acid ameliorates cardiac injury and adipose tissue inflammation in a rat model of metabolic syndrome Reviewed

Ito S, Sano Y, Nagasawa K, Matsuura N, Yamada Y, Uchinaka A, Murohara T, Nagata K

Obesity Science & Practice   Vol. 2 ( 3 ) page： 318-329   2016.9

Attenuation of cold stress-induced exacerbation of cardiac and adipose tissue pathology and metabolic disorders in a rat model of metabolic syndrome by the glucocorticoid receptor antagonist RU486 Reviewed

Nagasawa K, Matsuura N, Takeshita Y, Ito S, Sano Y, Yamada Y, Uchinaka A, Murohara T, Nagata K

Nutrition & Diabetes   Vol. 6   page： e207   2016.4

Blockade of glucocorticoid receptors with RU486 attenuates cardiac damage and adipose tissue inflammation in a rat model of metabolic syndrome Reviewed

Takeshita Y, Watanabe S, Hattori T, Nagasawa K, Matsuura N, Takahashi K, Murohara T, Nagata K

Hypertension Research   Vol. 38 ( 11 ) page： 741-750   2015.11

Restraint stress exacerbates cardiac and adipose tissue pathology via β-adrenergic signaling in rats with metabolic syndrome Reviewed

Matsuura N, Nagasawa K, Minagawa Y, Ito S, Sano Y, Yamada Y, Hattori T, Watanabe S, Murohara T, Nagata K

American Journal of Physiology Heart and Circulatory Physiology   Vol. 308 ( 10 ) page： H1275-H1286   2015.5

Roles of oxidative stress and the mineralocorticoid receptor in cardiac pathology in a rat model of metabolic syndrome Reviewed

Takahashi K, Murase T, Takatsu M, Matsuura N, Nagasawa K, Hattori T, Watanabe S, Murohara T, Nagata K

Nagoya Journal of Medical Science   Vol. 77 ( 1-2 ) page： 275-289   2015.2

Effects of pioglitazone on cardiac and adipose tissue pathology in rats with metabolic syndrome Reviewed

Matsuura N, Asano C, Nagasawa K, Ito S, Sano Y, Minagawa Y, Yamada Y, Hattori T, Watanabe S, Murohara T, Nagata K

International Journal of Cardiology   Vol. 179   page： 360-369   2015.1

Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats Reviewed

Nagasawa K, Takahashi K, Matsuura N, Takatsu M, Hattori T, Watanabe S, Harada E, Niinuma K, Murohara T, Nagata K

Hypertension Research   Vol. 38 ( 1 ) page： 39-47   2015.1

Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome Reviewed

Hattori T, Murase T, Takatsu M, Nagasawa K, Matsuura N, Watanabe S, Murohara T, Nagata K

Journal of the American Heart Association   Vol. 3 ( 6 ) page： e001312   2014.12

Elevated C-reactive protein levels and enhanced high frequency vasomotion in patients with ischemic heart disease during brachial flow-mediated dilation Reviewed

Watanabe S, Amiya E, Watanabe M, Takata M, Ozeki A, Watanabe A, Kawarasaki S, Nakao T, Hosoya Y, Nagata K, Nagai R, Komuro I

PLoS One   Vol. 9 ( 10 ) page： e110013   2014.10

Generation of rat-induced pluripotent stem cells from a new model of metabolic syndrome Reviewed

Takenaka-Ninagawa N, Kawabata Y, Watanabe S, Nagata K, Torihashi S

PLoS One   Vol. 9 ( 8 ) page： e104462   2014.8

Premature cardiac senescence in DahlS.Z-Leprfa/Leprfa rats as a new animal model of metabolic syndrome Reviewed

Takahashi K, Takatsu M, Hattori T, Murase T, Ohura S, Takeshita Y, Watanabe S, Murohara T, Nagata K

Nagoya Journal of Medical Science   Vol. 76 ( 1-2 ) page： 35-49   2014.2

Effects of salt status and blockade of mineralocorticoid receptors on aldosterone-induced cardiac injury Reviewed

Hattori T, Murase T, Sugiura Y, Nagasawa K, Takahashi K, Ohtake M, Ohtake M, Miyachi M, Murohara T, Nagata K

Hypertension Research   Vol. 37 ( 2 ) page： 125-133   2014.2

Glucocorticoids activate cardiac mineralocorticoid receptors in adrenalectomized Dahl salt-sensitive rats Reviewed

Ohtake M, Hattori T, Murase T, Takahashi K, Takatsu M, Ohtake M, Miyachi M, Watanabe S, Cheng XW, Murohara T, Nagata K

Nagoya Journal of Medical Science   Vol. 76 ( 1-2 ) page： 59-72   2014.2

Calorie restriction attenuates cardiac remodeling and diastolic dysfunction in a rat model of metabolic syndrome Reviewed

Takatsu M, Nakashima C, Takahashi K, Murase T, Hattori T, Ito H, Murohara T, Nagata K

Hypertension   Vol. 62 ( 5 ) page： 957-965   2013.11

Effects of aged garlic extract on left ventricular diastolic function and fibrosis in a rat hypertension model Reviewed

Hara Y, Noda A, Miyata S, Minoshima M, Sugiura M, Kojima J, Otake M, Furukawa M, Cheng XW, Nagata K, Murohara T

Experimental Animals   Vol. 62 ( 4 ) page： 305-310   2013.10

Glucocorticoid-induced hypertension and cardiac injury: effects of mineralocorticoid and glucocorticoid receptor antagonism Reviewed

Hattori T, Murase T, Iwase E, Takahashi K, Ohtake M, Tsuboi K, Ohtake M, Miyachi M, Murohara T, Nagata K

Nagoya Journal of Medical Science   Vol. 75 ( 1,2 ) page： 81-92   2013.2

新規メタボリック症候群ラットモデルを用いた高頻度対低頻度の運動トレーニングの心血管効果の比較検討 Reviewed

中島千恵子、高津美和、杉山大輔、辻村杏理沙、村井翔太郎、矢島美希、高橋圭司、村瀬珠代、服部拓哉、加藤洋介、室原豊明、永田浩三

心臓   Vol. 45 ( 2 ) page： 147-158   2013.2

循環器専門医が考える高血圧合併症のリスク管理（高血圧と心肥大形成・心不全発症）―心肥大を呈する高血圧におけるCa拮抗薬の心保護効果― Invited

永田浩三

循環plus   Vol. 13 ( 4 ) page： 7-9   2013.1

Dipeptidyl Peptidase-4 Modulates Left Ventricular Dysfunction in Chronic Heart Failure via Angiogenesis-Dependent and -Independent Actions Reviewed

Shigeta T, Aoyama M, Bando YK, Monji A, Mitsui T, Takatsu M, Cheng XW, Okumura T, Hirashiki A, Nagata K, Murohara T

Circulation   Vol. 126 ( 15 ) page： 1838-1851   2012.10

Comparison of the effects of cilnidipine and amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats Reviewed

Takatsu M, Hattori T, Murase T, Ohtake M, Kato M, Nashima K, Nakashima C, Takahashi K, Ito H, Niinuma K, Aritomi S, Murohara T, Nagata K

Journal of Hypertension   Vol. 30 ( 9 ) page： 1845-55   2012.9

Effects of estrogen on cardiovascular injury in ovariectomized female DahlS.Z-Leprfa/Leprfa rats as a new animal model of metabolic syndrome (An editorial commentary published by the journal) Reviewed

Murase T, Hattori T, Ohtake M, Nakashima C, Takatsu M, Murohara T, Nagata K

Hypertension   Vol. 59 ( 3 ) page： 694-704   2012.3

Cardiac remodeling and diastolic dysfunction in DahlS.Z-Leprfa/Leprfa rats: a new animal model of metabolic syndrome Reviewed

Murase T, Hattori T, Ohtake M, Abe M, Amakusa Y, Takatsu M, Murohara T, Nagata K

Hypertension Research   Vol. 35 ( 2 ) page： 186-93   2012.2

Angiotensin-converting enzyme inhibition promotes coronary angiogenesis in the failing heart of Dahl salt-sensitive hypertensive rats Reviewed

Yazawa H, Miyachi M, Furukawa M, Takahashi K, Takatsu M, Tsuboi K, Ohtake M, Murase T, Hattori T, Kato Y, Murohara T, Nagata K

Journal of Cardiac Failure   Vol. 17 ( 12 ) page： 1041-1050   2011.12

Cardioprotective mechanisms of lifestyle modifications and pharmacotherapies on cardiac remodeling and dysfunction in hypertensive heart disease: An overview Invited Reviewed

Nagata K, Hattori T

Nagoya Journal of Medical Science   Vol. 73 ( 3-4 ) page： 91-105   2011.8

Mechanism underlying the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertension Reviewed

Yamada Y, Tsuboi K, Hattori T, Murase T, Ohtake M, Furukawa M, Ueyama J, Nishiyama A, Murohara T, Nagata K

Hypertension Research   Vol. 34 ( 7 ) page： 809-816   2011.7

Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Leprfa/Leprfa rat Reviewed

Hattori T, Murase T, Ohtake M, Inoue T, Tsukamoto H, Takatsu M, Kato Y, Hashimoto K, Murohara T, Nagata K

Nutrition and Diabetes   Vol. 1   page： e1   2011.1

Ca2+ channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats Reviewed

Nishizawa T, Cheng XW, Jin Z, Obata K, Nagata K, Hirashiki A, Sasaki T, Noda A, Takeshita K, Izawa H, Shi GP, Kuzuya M, Okumura K, Murohara T

Journal of Hypertension   Vol. 28 ( 7 ) page： 1515-26   2010.7

Adiponectin acts as a positive indicator of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy Reviewed

Unno K, Shibata R, Izawa H, Hirashiki A, Murase Y, Yamada T, Kobayashi M, Noda A, Nagata K, Ouchi N, Murohara T, Murohara T

Heart   Vol. 96 ( 5 ) page： 357-361   2010.3

Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population Reviewed

Asano H, Izawa H, Nagata K, Nakatochi M, Kobayashi M, Hirashiki A, Shintani S, Nishizawa T, Tanimura D, Naruse K, Matsubara T, Murohara T, Yokota M

Diabetologia   Vol. 53 ( 2 ) page： 234-246   2010.2

Beneficial effects of growth hormone-releasing peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters Reviewed

Kato Y, Iwase M, Ichihara S, Kanazawa H, Hashimoto K, Noda A, Nagata K, Koike Y, Yokota M

Circulation Journal   Vol. 74 ( 1 ) page： 163-170   2010.1

Evidence for the importance of adiponectin in the cardioprotective effects of pioglitazone Reviewed

Li P, Shibata R, Unno K, Shimano M, Furukawa M, Ohashi T, Cheng X, Nagata K, Ouchi N, Murohara T

Hypertension   Vol. 55 ( 1 ) page： 69-75   2010.1

Mutation of ARHGAP9 in patients with coronary spastic angina Reviewed

Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K

Journal of Human Genetics   Vol. 55 ( 1 ) page： 42-49   2010.1

Endomyocardial Radial Strain Imaging and Left Ventricular Relaxation Abnormalities in Patients With Hypertrophic Cardiomyopathy or Hypertensive Left Ventricular Hypertrophy Reviewed

Minoshima M, Noda A, Nishizawa T, Hara Y, Sugiura M, Iino S, Nagata K, Koike Y, Murohara T

Circulation Journal   Vol. 73 ( 12 ) page： 2294-2299   2009.12

Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats Reviewed

Yamada T, Nagata K, Cheng XW, Obata K, Saka M, Miyachi M, Naruse K, Nishizawa T, Noda A, Izawa H, Kuzuya M, Okumura K, Murohara T, Yokota M

European Journal of Pharmacology   Vol. 615 ( 1-3 ) page： 163-170   2009.8

Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy Reviewed

Unno K, Isobe S, Izawa H, Cheng XW, Kobayashi M, Hirashiki A, Yamada T, Harada K, Ohshima S, Noda A, Nagata K, Kato K, Yokota M, Murohara T

European Heart Journal   Vol. 30 ( 15 ) page： 1853-1862   2009.8

Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers Reviewed

Cheng XW, Okumura K, Kuzuya M, Jin Z, Nagata K, Obata K, Inoue A, Hirashiki A, Takeshita K, Unno K, Harada K, Shi GP, Yokota M, Murohara T

Journal of Cardiovascular Pharmacology   Vol. 54 ( 1 ) page： 47-56   2009.7

Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure: comparison with azosemide Reviewed

Harada K, Izawa H, Nishizawa T, Hirashiki A, Murase Y, Kobayashi M, Isobe S, Cheng XW, Noda A, Nagata K, Yokota M, Murohara T

Journal of Cardiovascular Pharmacology   Vol. 53 ( 6 ) page： 468-473   2009.6

Response to exercise generates lactate and fluid intake; effects on mitochondrial function in heart and vascular smooth muscle Invited Reviewed

Miyachi M, Nagata K

Hypertension   Vol. 54   page： e15   2009.6

Exercise training alters left ventricular geometry and attenuates heart failure in Dahl salt-sensitive hypertensive rats (An editorial commentary published by the journal) Reviewed

Miyachi M, Yazawa H, Furukawa M, Tsuboi K, Ohtake M, Nishizawa T, Hashimoto K, Yokoi T, Kojima T, Murate T, Yokota M, Murohara T, Koike Y, Nagata K

Hypertension   Vol. 53 ( 4 ) page： 701-707   2009.4

Dobutamine stress testing as a diagnostic tool for evaluation of myocardial contractile reserve in asymptomatic or mildly symptomatic patients with dilated cardiomyopathy Reviewed

Kobayashi M, Izawa H, Cheng XW, Asano H, Hirashiki A, Unno K, Ohshima S, Yamada T, Murase Y, Kato TS, Obata K, Noda A, Nishizawa T, Isobe S, Nagata K, Matsubara T, Murohara T, Yokota M

JACC: Cardiovascular Imaging   Vol. 1 ( 6 ) page： 718-726   2008.11

Heterogeneity of regional systolic function detected by tissue doppler imaging is linked to impaired global left ventricular relaxation in hypertrophic cardiomyopathy

Kato TS, Izawa H, Komamura K, Noda A, Asano H, Nagata K, Hashimoto S, Oda N, Kamiya C, Kanzaki H, Hashimura K, Nakatani T, Ueda HI, Murohara T, Kitakaze M, Yokota M

Heart   Vol. 94 ( 10 ) page： 1302-1306   2008.10

Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment Reviewed

Cheng XW, Murohara T, Kuzuya M, Izawa H, Sasaki T, Obata K, Nagata K, Nishizawa T, Kobayashi M, Yamada T, Kim W, Sato K, Shi GP, Okumura K, Yokota M

American Journal of Pathology   Vol. 173 ( 2 ) page： 358-369   2008.8

Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt Reviewed

Kato MF, Shibata R, Obata K, Miyachi M, Yazawa H, Tsuboi K, Yamada T, Nishizawa T, Noda A, Cheng XW, Murate T, Koike Y, Murohara T, Yokota M, Nagata K

Journal of Hypertension   Vol. 26 ( 8 ) page： 1669-1676   2008.8

Mineralocorticoid antagonism and cardiac hypertrophy Invited Reviewed

Nagata K

Current Hypertension Reports   Vol. 10 ( 3 ) page： 216-221   2008.6

Molecular defects associated with antithrombin deficiency and dilated cardiomyopathy in a Japanese patient Reviewed

Fujimori Y, Okimatsu H, Kashiwagi T, Sanda N, Okumura K, Takagi A, Nagata K, Murate T, Uchida A, Node K, Saito H, Kojima T

Internal Medicine   Vol. 47 ( 10 ) page： 925-931   2008.5

Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters Reviewed

Hayashi K, Kimata H, Obata K, Matsushita A, Fukata A, Hashimoto K, Noda A, Iwase M, Koike Y, Yokota M, Nagata K

Journal of Cardiac Failure   Vol. 14 ( 3 ) page： 238-244   2008.4

Aldosterone modulates If current through gene expression in cultured neonatal rat ventricular myocytes Reviewed

Muto T, Ueda N, Opthof T, Ohkusa T, Nagata K, Suzuki S, Tsuji Y, Horiba M, Lee JK, Honjo H, Kamiya K, Kodama I, Yasui K

American Journal of Physiology Heart and Circulatory Physiology   Vol. 293 ( 5 ) page： H2710-H2718   2007.11

Wilms' tumor 1 message and protein expression in bone marrow failure syndrome and acute leukemia Reviewed

Iwasaki T, Sugisaki C, Nagata K, Takagi K, Takagi A, Kojima T, Ito M, Nakamura S, Naoe T, Murate T

Pathology International   Vol. 57 ( 10 ) page： 645-651   2007.10

Differential cardiovascular effects of endotoxin derived from Escherichia coli or Pseudomonas aeruginosa Reviewed

Matsushita A, Iwase M, Kato Y, Ichihara S, Ichihara G, Kimata H, Hayashi K, Hashimoto K, Yokoi T, Noda A, Koike Y, Yokota M, Nagata K

Experimental Animals   Vol. 56 ( 5 ) page： 339-348   2007.10

Diversity of the elevation of serum cardiac troponin I levels in patients during their first visit to the emergency room Reviewed

Saiki A, Iwase M, Takeichi Y, Umeda H, Ishiki R, Inagaki H, Kato Y, Nagata K, Koike Y

Circulation Journal   Vol. 71 ( 9 ) page： 1458-1462   2007.9

Continuous positive airway pressure improves daytime baroreflex sensitivity and nitric oxide production in patients with moderate to severe obstructive sleep apnea syndrome Reviewed

Noda A, Nakata S, Koike Y, Miyata S, Kitaichi K, Nishizawa T, Nagata K, Yasuma F, Murohara T, Yokota M

Hypertension Research   Vol. 30 ( 8 ) page： 669-676   2007.8

Beneficial effect of bilevel positive airway pressure on left ventricular function in ambulatory patients with idiopathic dilated cardiomyopathy and central sleep apnea-hypopnea: a preliminary study Reviewed

Noda A, Izawa H, Asano H, Nakata S, Hirashiki A, Murase Y, Iino S, Nagata K, Murohara T, Koike Y, Yokota M

Chest   Vol. 131 ( 6 ) page： 1694-1701   2007.6

Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway Reviewed

Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Noda A, Izawa H, Nagata K, Yokota M

Clinical and Experimental Pharmacology and Physiology   Vol. 33 ( 12 ) page： 1164-1171   2006.12

Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes Reviewed

Sobue S, Iwasaki T, Sugisaki C, Nagata K, Kikuchi R, Murakami M, Takagi A, Kojima T, Banno Y, Akao Y, Nozawa Y, Kannagi R, Suzuki M, Abe A, Naoe T, Murate T

Leukemia   Vol. 20 ( 11 ) page： 2042-2046   2006.11

Differential myolysis of myocardium and skeletal muscle in hamsters with dilated cardiomyopathy Reviewed

Kato Y, Iwase M, Takagi K, Nishizawa T, Kanazawa H, Matsushita A, Umeda H, Izawa H, Noda A, Koike Y, Nagata K, Yokota M

Circulation Journal   Vol. 70 ( 11 ) page： 1497-1502   2006.11

Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure Reviewed

Cheng XW, Obata K, Kuzuya M, Izawa H, Nakamura K, Asai E, Nagasaka T, Saka M, Kimata T, Noda A, Nagata K, Jin H, Shi GP, Iguchi A, Murohara T, Yokota M

Hypertension   Vol. 48 ( 5 ) page： 979-987   2006.11

Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors Reviewed

Ichihara S, Obata K, Yamada Y, Nagata K, Noda A, Ichihara G, Yamada A, Kato T, Izawa H, Murohara T, Yokota M

Journal of Molecular and Cellular Cardiology   Vol. 41 ( 2 ) page： 318-329   2006.8

狭心症治療薬ニコランジルの多面的効果 Invited

永田浩三，小畑孝ニ，横田充弘

循環器科   Vol. 60 ( 2 ) page： 148-156   2006.8

Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure Reviewed

Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Nishizawa T, Noda A, Izawa H, Nagata K, Murohara T, Yokota M

Journal of Cardiovascular Pharmacology   Vol. 47 ( 6 ) page： 770-779   2006.6

Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats (An editorial commentary published by the journal) Reviewed

Nagata K, Obata K, Xu J, Ichihara S, Noda A, Kimata H, Kato T, Izawa H, Murohara T, Yokota M

Hypertension   Vol. 47 ( 4 ) page： 656-664   2006.4

Prognostic value of pacing-induced mechanical alternans in patients with mild-to-moderate idiopathic dilated cardiomyopathy in sinus rhythm Reviewed

Hirashiki A, Izawa H, Somura F, Obata K, Kato T, Nishizawa T, Yamada A, Asano H, Ohshima S, Noda A, Iino S, Nagata K, Okumura K, Murohara T, Yokota M

Journal of the American College of Cardiology   Vol. 47 ( 7 ) page： 1382-1389   2006.4

The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion Reviewed

Umeda H, Katoh T, Iwase M, Izawa H, Nagata K, Watanabe K, Okada T, Yamada T, Tani T, Matsushita T, Murakami Y, Okamoto M, Shimizu T, Murohara T, Yokota M

Circulation Journal   Vol. 70 ( 3 ) page： 232-238   2006.3

Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure Reviewed

Ichihara S, Noda A, Nagata K, Obata K, Xu J, Ichihara G, Oikawa S, Kawanishi S, Yamada Y, Yokota M

Cardiovascular Research   Vol. 69 ( 3 ) page： 726-735   2006.2

Cardiac sympathetic dysfunction correlates with abnormal myocardial contractile reserve in dilated cardiomyopathy patients Reviewed

Satoru Ohshima, Satoshi Isobe, Hideo Izawa, Mamoru Nanasato, Akitada Ando, Akira Yamada, Kiyoyasu Yamada, Tomoko Kato, Koji Obata, Akiko Noda, Takao Nishizawa, Katsuhiko Kato, Kohzo Nagata, Kenji Okumura, Toyoaki Murohara, Mitsuhiro Yokota

Journal of the American College of Cardiology   Vol. 46 ( 11 ) page： 2061-2068.   2005.12

Overexpression of calmodulin induces cardiac hypertrophy by a calcineurin-dependent pathway Reviewed

Koji Obata, Kohzo Nagata, Mitsunori Iwase, Mari Odashima, Tetsuro Nagasaka, Hideo Izawa, Toyoaki Murohara, Yoshiji Yamada, Mitsuhiro Yokota

Biochemical and Biophysical Research Communications   Vol. 338 ( 2 ) page： 1299-1305   2005.12

Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study Reviewed

Izawa H, Murohara T, Nagata K, Isobe S, Asano H, Amano T, Ichihara S, Kato T, Ohshima S, Murase Y, Iino S, Obata K, Noda A, Okumura K, Yokota M

Circulation   Vol. 112 ( 19 ) page： 2940-2945   2005.11

Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats (An editorial commentary published by the journal) Reviewed

Jinglan Xu, Kohzo Nagata, Koji Obata, Sahoko Ichihara, Hideo Izawa, Akiko Noda, Tetsuro Nagasaka, Mitsunori Iwase, Toyoaki Murohara, Mitsuhiro Yokota

Hypertension   Vol. 46 ( 4 ) page： 719-24   2005.10

Cardiac 123I-MIBG reflects left ventricular functional reserve in patients with nonobstructive hypertrophic cardiomyopathy Reviewed

Satoshi Isobe, Hideo Izawa, Mitsunori Iwase, Mamoru Nanasato, Makoto Nonokawa, Akitada Ando, Satoru Ohshima, Kohzo Nagata, Katsuhiko Kato, Takao Nishizawa, Toyoaki Murohara, Mitsuhiro Yokota

Journal of Nuclear Medicine   Vol. 46 ( 6: ) page： 909-916   2005.6

Discrimination of nonobstructive hypertrophic cardiomyopathy from hypertensive left ventricular hypertrophy on the basis of strain rate imaging by tissue Doppler ultrasonography Reviewed

Tomoko S. Kato, Akiko Noda, Hideo Izawa, Akira Yamada, Koji Obata, Kohzo Nagata, Mitsunori Iwase, Toyoaki Murohara, Mitsuhiro Yokota

Circulation   Vol. 110 ( 25 ) page： 3808-3814   2004.12

Serial alterations of β-adrenergic signaling in dilated cardiomyopathic hamsters: possible role of myocardial oxidative stress Reviewed

Takao Nishizawa, Mitsunori Iwase, Hiroaki Kanazawa, Sahoko Ichihara, Gaku Ichihara, Kohzo Nagata, Koji Obata, Kiyoyuki Kitaichi, Toyoharu Yokoi, Masato Watanabe, Takashi Tsunematsu, Yoshihiro Ishikawa, Toyoaki Murohara, Mitsuhiro Yokota

Circulation Journal   Vol. 68 ( 11 ) page： 1051-1060   2004.11

Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese Reviewed

Akira Yamada, Sahoko Ichihara, Yosuke Murase, Tomoko Kato, Hideo Izawa, Kohzo Nagata, Toyoaki Murohara, Yoshiji Yamada, Mitsuhiro Yokota

Journal of Molecular Medicine   Vol. 82 ( 7 ) page： 477-483   2004.7

Blunt circulatory response to exercise in coronary high-risk subjects among apparently healthy Japanese Reviewed

Ichihara Y, Ohno J, Suzuki M, Anno T, Sugino M, Nagata K

Circulation Journal   Vol. 68 ( 4 ) page： 286-293   2004.4

Promising efficacy of primary gradual and prolonged balloon angioplasty in small coronary arteries: A randomized comparison with cutting balloon angioplasty and conventional balloon angioplasty Reviewed

Umeda H, Iwase M, Kanda H, Izawa H, Nagata K, Ishiki R, Sawada K, Murohara T, Yokota M

American Heart Journal   Vol. 147 ( 1 ) page： E4   2004.1

Growth hormone-releasing peptide can improve left ventricular dysfunction and attenuate dilation in dilated cardiomyopathic hamsters Reviewed

Iwase M, Kanazawa H, Kato Y, Nishizawa T, Somura F, Ishiki R, Nagata K, Hashimoto K, Takagi K, Izawa H, Yokota M

Cardiovascular Research   Vol. 61 ( 1 ) page： 30-38   2004.1

Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia Reviewed

Keiko Shimokata, Yoshiji Yamada, Takahisa Kondo, Sahoko Ichihara, Hideo Izawa, Kohzo Nagata, Toyoaki Murohara, Miyoshi Ohno, Mitsuhiro Yokota

Atherosclerosis   Vol. 172 ( 1 ) page： 167-173   2004.1

Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect

Nagata K, Obata K, Odashima M, Yamada A, Somura F, Nishizawa T, Ichihara S, Izawa H, Iwase M, Hayakawa A, Murohara T, Yokota M

Journal of Molecular and Cellular Cardiology   Vol. 35 ( 12 ) page： 1505-1512   2003.12

成人病と生活習慣病：循環器疾患の非薬物治療―現状と今後の展開―心筋の再生治療 Invited

永田浩三，横田充弘，室原豊明

成人病と生活習慣病   Vol. 33 ( 8 ) page： 931-935   2003.8

Biphasic relaxation-frequency relations in patients with effort angina pectoris: a new marker of myocardial demand ischemia Reviewed

Hisashi Umeda,Mitsunori Iwase,Hideo Izawa,Takao Nishizawa,Makoto Nonokawa,Satoshi Isobe,Akiko Noda,Kohzo Nagata,Hitoshi Ishihara,Mitsuhiro Yokota

American Heart Journal   Vol. 146 ( 1 ) page： 75-83   2003.7

Validity and application of noninvasive measurement of blood pressure in hamsters Reviewed

Yosuke Kato,Mitsunori Iwase,Hiroaki Kanazawa,Takao Nishizawa,Ying Lan Zhao,Kenji Takagi,Kohzo Nagata,Akiko Noda,Yasuo Koike,Mitsuhiro Yokota

Experimental Animals   Vol. 52 ( 4 ) page： 359-363   2003.7

Myocardial velocity gradient as a noninvasively determined index of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy Reviewed

Tomoko Kato,Akiko Noda,Hideo Izawa,Takao Nishizawa,Fuji Somura,Akira Yamada,Kohzo Nagata,Mitsunori Iwase,Akimasa Nakao,Mitsuhiro Yokota

Journal of the American College of Cardiology   Vol. 42 ( 2 ) page： 278-285   2003.7

Effect of nicorandil on left ventricular end-diastolic pressure during exercise in patients with hypertrophic cardiomyopathy Reviewed

Hideo Izawa,Mitsunori Iwase,Yasushi Takeichi,Fuji Somura,Kohzo Nagata,Takao Nishizawa,Akiko Noda,Toyoaki Murohara,Mitsuhiro Yokota

European Heart Journal   Vol. 24 ( 14 ) page： 1340-1348   2003.7

AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats Reviewed

Nagata K, Somura F, Obata K, Odashima M, Izawa H, Ichihara S, Nagasaka T, Iwase M, Yamada Y, Nakashima N, Yokota M

Hypertension   Vol. 40 ( 2 ) page： 168-174   2002.8

Higher C-reactive protein concentration and white blood cell count in subjects with more coronary risk factors and/or lower physical fitness among apparently healthy Japanese

Ichihara Y, Ohno J, Suzuki M, Anno T, Sugino M, Nagata K

Circulation Journal   Vol. 66 ( 7 ) page： 677-684   2002.7

Effects of FK506 and rapamycin on formation of the neural tube in chick embryos Reviewed

Koji Obata,Masafumi Koide,Kohzo Nagata,Akio Iio,Shigenobu Yazawa,Tamao Ono,Shin-ichi Sasaki,Yoshiji Yamada,Rocky S.Tuan,Mitsuhiro Yokota

Animal Science Journal   Vol. 73 ( 3 ) page： 229-234   2002.6

Prognostic value of mechanical efficiency in ambulatory patients with idiopathic cardiomyopathy in sinus rhythm Reviewed

Il Sung Kim,Hideo Izawa,Toshikazu Sobue,Hitoshi Ishihara,Fuji Somura,Takao Nishizawa,Kohzo Nagata,Mitsunori Iwase,Mitsuhiro Yokota

Journal of the American College of Cardiology   Vol. 39 ( 8 ) page： 1264-1268   2002.4

Biphasic changes in left ventricular end-diastolic pressure during dynamic exercise in patients with nonobstructive hypertrophic cardiomyopathy Reviewed

Yasushi Takeichi,Mitsuhiro Yokota,Mitsunori Iwase,Hideo Izawa,Takao Nishizawa,Ryoji Ishiki,Fuji Somura,Kohzo Nagata,Satoshi Isobe,Akiko Noda

Journal of the American College of Cardiology   Vol. 38 ( 2 ) page： 335-343   2001.8

Reduced myocardial sarcoplasmic reticulum Ca2+-ATPase mRNA expression and biphasic force-frequency relations in patients with hypertrophyc cardiomyopathy Reviewed

Fuji Somura,Hideo Izawa,Mitsunori Iwase,Yasushi Takeichi,Ryoji Ishiki,Takao Nishizawa,Akiko Noda,Kohzo Nagata,Yoshiji Yamada,Mitsuhiro Yokota

Circulation   Vol. 104 ( 6 ) page： 658-663   2001.8

Role of FK506-binding protein 12 in development of the chick embryonic heart Reviewed

Koji Obata,Masafumi Koide,Kohzo Nagata,Akio Iio,Shigenobu Yazawa,Tamao Ono,Yoshiji Yamada,Rocky S.Tuan,Mitsuhiro Yokota

Biochemical and Biophysical Research Communications   Vol. 283 ( 3 ) page： 613-620   2001.5

Targeted inactivation of Gαi does not alter cardiac function or β-adrenergic sensitivity Reviewed

Jain M, Lim CC, Nagata K, Davis VM, Milstone DS, Liao R, Mortensen RM

American Journal of Physiology Heart and Circulatory Physiology   Vol. 280 ( 2 ) page： H569-H575   2001.2

Gαi2 but not Gαi3 is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes Reviewed

Nagata K, Ye C, Jain M, Milstone DS, Liao R, Mortensen RM

Circulation Research   Vol. 87 ( 10 ) page： 903-909   2000.11

Altered β-adrenergic signal transduction in nonfailing hypertrophied myocytes from Dahl salt-sensitive rats Reviewed

Nagata K, Communal C, Lim CC, Jain M, Suter TM, Eberli FR, Satoh N, Colucci WS, Apstein CS, Liao R

American Journal of Physiology Heart and Circulatory Physiology   Vol. 279 ( 5 ) page： H2502-H2508.   2000.11

Different β-adrenergic regulation of myocardial contraction and relaxation between apical and nonobstructive hypertrophic cardiomyopathy Reviewed

Ping Zuo,Hideo Izawa,Ryoji Ishiki,Akiko Noda,Takao Nishizawa,Kazushige Shigemura,Kohzo Nagata,Mitsunori Iwase,Mitsuhiro Yokota

American Heart Journal   Vol. 140 ( 2 ) page： 329-337   2000.8

Acute effects of a single low oral dose of pimobendan on left ventricular systolic and diastolic function in patients with congestive heart failure Reviewed

Ryoji Ishiki,Hitoshi Ishihara,Hideo Izawa,Kohzo Nagata,Makoto Hirai,Mitsuhiro Yokota

Journal of Cardiovascular Pharmacology   Vol. 35 ( 6 ) page： 897-905   2000.6

Impaired force- frequency relations in patients with hypertensive left ventricular hypertrophy. : A possible physiological marker of the trnsition from physiologica to pathological hypertrophy Reviewed

Masafumi Inagaki,Mitsuhiro Yokota,Hideo Izawa,Ryoji Ishiki,Kohzo Nagata,Mitsunori Iwase,Yoshiji Yamada,Masafumi Koide,Toshikazu Sobue

Circulation   Vol. 274 ( 14 ) page： 1822-1830   1999.4

Early changes in excitation-contraction coupling: transition from compensated hypertrophy to failure in Dahl salt-sensitive rat myocytes Reviewed

Nagata K, Liao R, Eberli FR, Satoh N, Chevalier B, Apstein CS, Suter TM

Cardiovascular Research   Vol. 37 ( 2 ) page： 467-477   1998.2

Dynamic exercise-induced changes in diastolic properties of the regional myocarduium in hypertensive left ventricular hypertrophy Reviewed

Yasushi Takeichi,Kohzo Nagata,Hideo Izawa,Mitsunori Iwase,Toshikazau Sobue,Motoaki Sugawara,Mitsuhiro Yokota

Heart and Vessels   Vol. Suppl.12   page： 138-141   1997.12

Adrenergic control of the force-frequency and relaxation-frequency relations in patients with hypertrophic cardiomyopathy Reviewed

Hideo Izawa,Mitsuhiro Yokota,Yasushi Takeichi,Masafumi Inagaki,Kohzo Nagata,Mitsunori Iwase,Toshikazu Sobue

Circulation   Vol. 96 ( 9 ) page： 2959-2968   1997.11

Effect of dobutamine and OPC-18790 on diastolic chamber stiffness in patients with idiopathic dilated cardiomyopathy Reviewed

Takeshi Machii,Mitsuhiro Yokota,Kohzo Nagata,Hitoshi Ishihara,Mitsunori Iwase,Toshikazu Sobue

Journal of Cardiovascular Pharmacology   Vol. 29 ( 2 ) page： 265-272   1997.2

Impaired response of left ventricular relaxation to exercise-induced adrenergic stimulation in patients with hypertrophic cardiomyopathy Reviewed

Hideo Izawa,Mitsuhiro Yokota,Kohzo Nagata,Mitsunori Iwase,Toshikazu Sobue

Journal of the American College of Cardiology   Vol. 28 ( 7 ) page： 1738-1745   1996.12

A novel inotropic vasodilator, OPC-18790, reduces myocardial oxygen consumption and improves mechanical efficiency with congestive heart failure Reviewed

Hirofumi Kanda,Mitsuhiro Yokota,Hitoshi Ishihara,Kohzo Nagata,Ryozo Kato,Toshikazu Sobue

American Heart Journal   Vol. 132 ( 2 ) page： 361-368   1996.8

Differential effects of dobutamine and a phosphodiesterase inhibitor on early diastolic filling in patients with congestive heart failure Reviewed

Nagata K, Iwase M, Sobue T, Yokota M

Journal of the American College of Cardiology   Vol. 25 ( 2 ) page： 295-304   1995.2

Hemodynamic effects of the calcium channel blocker pranidipine on exercise-induced angina Reviewed

Yasuto Nishinaka,Mitsuhiro Yokota,Makoto Watanabe,Toshikazu Sobue,Mitsunori Iwase,Masahiko Ukai,Akitada Ando,Kohzo Nagata,Hidehiko Saito

International Journal of Clinical Pharmacology and Therapeutics   Vol. 32 ( 10 ) page： 542-549   1994.10

－特集－「運動と心臓」 Invited

横田充弘，永田浩三

CARDIAC PRACTICE   Vol. 5 ( 3 ) page： 63-68   1994.7

Age-related changes in left and right ventricular filling velocity profiles and their relationship in normal subjects Reviewed

Mitsunori Iwase,Kozo Nagata,Hideo Izawa,Mitsuhiro Yokota, Susumu Kamihara,Haruo Inagaki,Hidehiko Saito

American Heart Journal   Vol. 126 ( 2 ) page： 419-426   1993.8

強心薬―現状と将来への展望―（厚生省循環器病研究委託事業強心薬の有効性に関する基礎的、および臨床的研究班会議）。「慢性心不全の病態と強心作用に関する基礎的概念」、2. 拡張機能と強心作用

篠山重威編。横田充弘、永田浩三（ Role： Joint author）

南江堂  1996.4 

CARDIAC PRACTICE：「運動と心臓」。運動負荷ドプラ法による心機能評価

横田充弘、永田浩三（ Role： Joint author）

メディカルレビュー社  1994.7 

L-アルギニンはメタボリックシンドロームラットの高血圧および心筋ミトコンドリア機能と動態異常を改善する

田上 海斗、奥澤 透子、早川 美咲、崔 茜茜、三島 凛、吉田 恵輔、小原 菜月、國松 明日子、小出 眞弥子、寺西 環海、板倉 広治、池田 勝秀、室原 豊明、永田 浩三

第45回日本高血圧学会総会  2023.9.15  日本高血圧学会

The mitochondria-targeted antioxidant mitoquinol ameliorates cardiac fibrosis and diastolic dysfunction in rats with metabolic syndrome

Touko Okuzawa, Kaito Tagami, Tamami Teranishi, Natsuki Obara, Asuko Kunimatsu, Mayako Koide, Katsuhide Ikeda, Toyoaki Murohara, Kohzo Nagata

The 87th Annual Scientific Meeting of the Japanese Circulation Society (JCS2023)   2023.3.11 

L-arginine supplementation ameliorates hypertension and cardiac mitochondrial abnormalities but not cardiac injury in rats with metabolic syndrome

Kaito Tagami, Touko Okuzawa, Misaki Hayakawa, Xixi Cui, Natsuki Obara, Asuko Kunimatsu, Mayako Koide, Tamami Teranishi, Koji Itakura, Katsuhide Ikeda, Toyoaki Murohara, Kohzo Nagata

The 87th Annual Scientific Meeting of the Japanese Circulation Society (JCS2023)   2023.3.10 

Comparative effects of renal denervation in different stages of hypertension on cardiac, renal, and adipose pathology in Dahl salt-sensitive rats International conference

Kohzo Nagata, Kaito Tagami, Toko Okuzawa, Misaki Hayakawa, Akane Nomura, Tomo Nishimura, Nozomi Furukawa, Nanako Sakabe, Katsuhide Ikeda, Shuhei Kobuchi, Kento Kitada, Yoshihide Fujisawa, Akira Nishiyama, Toyoaki Murohara

The 29th Scientific Meeting of the International Society of Hypertension (Hypertension Kyoto 2022)  2022.10.15  International Society of Hypertension (ISH), Asian Pacific Society of Hypertension (APSH), Japanese Society of Hypertension (JSH)

L-arginine supplementation substantially attenuates hypertension but not cardiac injury in rats with metabolic syndrome International conference

Kaito Tagami, Touko Okuzawa, Misaki Hayakawa, Xixi Cui, Natsuki Obara, Asuko Kunimatsu, Mayako Koide, Tamami Teranishi, Nozomi Furukawa, Nanako Sakabe, Katsuhide Ikeda, Toyoaki Murohara, Kohzo Nagata

The 29th Scientific Meeting of the International Society of Hypertension (Hypertension Kyoto 2022)  2022.10.15  International Society of Hypertension (ISH), Asian Pacific Society of Hypertension (APSH), Japanese Society of Hypertension (JSH)

L-arginine supplementation substantially ameliorates hypertension but does not improve LV hypertrophy, inflammation, fibrosis, or diastolic dysfunction in metabolic syndrome rats

Misaki Hayakawa, Xixi Cui, Nozomi Furukawa, Chiharu Isogai, Toko Okuzawa, Saki Shirota, Kaito Tagami, Nanako Sakabe, Katsuhide Ikeda, Kohzo Nagata

The 86th Annual Scientific Meeting of the Japanese Circulation Society (JCS2022)   2022.3.13 

大豆タンパクはメタボリックシンドロームラットのインスリン抵抗性と心筋傷害を改善するとともに、皮下脂肪のミトコンドリア由来活性酸素種産生を抑制する [SHR賞（Splendid basic Hypertension Research Award）]

崔茜茜、古川希、河合夢乃、早川美咲、西村知、野村茜、坂部 名奈子、池田勝秀、永田浩三

第43回日本高血圧学会総会  2021.10.15  日本高血圧学会

Dahl食塩感受性ラットに対する腎神経アブレーションの高血圧、心・腎・脂肪病態への影響の検討—アブレーション実施時期による効果の相違—

早川美咲、野村茜、西村知、古川希、中野志保、小渕修平、芦川采央、河合夢乃、崔茜茜、坂部 名奈子、池田勝秀、北田研人、藤澤良秀、西山成、永田浩三

第43回日本高血圧学会総会  2021.10.15  日本高血圧学会

A hot water extract of low curcumin Curcuma longa ameliorates cardiac and subcutaneous fat inflammation in rats with metabolic syndrome.

Nozomi Furukawa, Yumeno Kawai, Xixi Cui, Kana Hirota, Hirona Mori, Yurina Ishida, Yuka Hirano, Misaki Ikei, Katsuhide Ikeda, Kohzo Nagata

The 85th Annual Scientific Meeting of the Japanese Circulation Society (JCS2021)  2021.3.26 

Dietary soy protein exacerbates cardiac hypertrophy but ameliorates cardiac fibrosis and diastolic dysfunction in rats with metabolic syndrome

Xixi Cui, Yumeno Kawai, Misaki Ikei, Tomo Nishimura, Akane Nomura, Nozomi Furukawa, Katsuhide Ikeda, Kohzo Nagata

The 85th Annual Scientific Meeting of the Japanese Circulation Society (JCS2021)  2021.3.26 

Differential effects of low-carbohydrate, high-fat ketogenic diets with different fat sources on cardiac and adipose tissue pathology in rats with metabolic syndrome

Yumeno Kawai, Xixi Cui, Shiho Nakano, Sao Ashikawa, Yurina Ishida, Yuka Hirano, Kana Hirota, Hirona Mori, Katsuhide Ikeda, Kohzo Nagata

The 4th JCS Council Forum on Basic CardioVascular Research (BCVR2020)  2020.9.26 

Age-Related Vascular Dysfunction of the Aorta in Rats with Metabolic Syndrome

Yumeno Kawai, Yurina Ishida, Yuka Hirano, Kana Hirota Hirona Mori, Yuki Komatsu, Kiyoshi Aoyama, Shiho Nakano, Sao Ashikawa, Xixi Cui, Toyoaki Murohara, Kohzo Nagata

The 84th Annual Scientific Meeting of the Japanese Circulation Society (JCS2020)  2020.7.27 

メタボリックシンドロームラットの心臓と脂肪の病態に及ぼすカルシウムおよびビタミンDの影響の検討

中野志保、青山清志、小松優希、芦川采央、河合夢乃、石田有里菜、平野佑果、廣田佳奈、森裕名、崔茜茜、室原豊明、永田浩三

第42回日本高血圧学会総会  2019.10.26  日本高血圧学会

メタボリックシンドロームのラットモデルにおける心筋および脂肪のミトコンドリア機能解析

河合夢乃、綿谷美南、藤枝愛生、小室佳那子、小松優希、青山清志、中野志保、芦川采央、室原豊明、永田浩三

第42回日本高血圧学会総会  2019.10.26  日本高血圧学会

PTEN阻害薬は脂肪炎症の抑制と冠血管新生の促進により拘束ストレス負荷したメタボリックシンドロームラットの心筋病態の悪化を抑制する

芦川采央、中野志保、青山清志、小松優希、河合夢乃、室原豊明、永田浩三

第42回日本高血圧学会総会  2019.10.25  日本高血圧学会

PTEN inhibition improves cardiac pathology and attenuates adipose inflammation by increasing regulatory B cells in stressed rats with metabolic syndrome

Sao Ashikawa, Ayako Uchinaka, Shiho Nakano, Kiyoshi Aoyama, Yuki Komatsu, Toyoaki Murohara, Kohzo Nagata

The 83th Annual Scientific Meeting of the Japanese Circulation Society (JCS2019)  2019.3.29 

Altered cardiac autonomic activity triggers sudden cardiac death in rats with metabolic syndrome

Shiho Nakano, Ayako Uchinaka, Moeko Minamiya, Naoki Azuma, Hisashi Mizumoto, Mamoru Yoneda, Yuki Komatsu, Kiyoshi Aoyama, Sao Ashikawa, Toyoaki Murohara, Kohzo Nagata

The 83th Annual Scientific Meeting of the Japanese Circulation Society (JCS2019)  2019.3.29 

メタボリックシンドロームラットにおけるイヌリンの心筋・肝臓病態および血清脂質に及ぼす影響（TGBM poster award候補発表）

小松優希、内仲彩子、青山清志、米田護、中野志保、芦川采央、東直希、水本尚志、南谷萌子、室原豊明、永田浩三

中性脂肪学会第2回学術集会 

Altered cardiac autonomic activity, arrhythmias, and cardiac death in a rat model of metabolic syndrome International conference

Kohzo Nagata, Shiho Nakano, Moeko Minamiya, Naoki Azuma, Hisashi Mizumoto, Mamoru Yoneda, Yuki Komatsu, Kiyoshi Aoyama, Sao Ashikawa, Toyoaki Murohara, Ayako Uchinaka

The 27th Scientific Meeting of the International Society of Hypertension 

メタボリックシンドロームラットへの食物繊維の投与は、内臓脂肪、心筋および肝臓の病態を改善する

小松優希、内仲彩子、青山清志、米田護、中野志保、芦川采央、東直希、水本尚志、南谷萌子、室原豊明、永田浩三

第41回日本高血圧学会総会 

メタボリックシンドロームラットの心臓自律神経活動と病態の関連

中野志保、内仲彩子、南谷萌子、東直希、水本尚志、米田護、小松優希、青山清志、芦川采央、室原豊明、永田浩三

第41回日本高血圧学会総会 

食塩負荷したメタボリックシンドロームラットにおいて皮下脂肪の外科的摘出は心筋および脂肪病態の増悪を抑制する

青山清志、内仲彩子、小松優希、米田護、中野志保、芦川采央、東直希、水本尚志、南谷萌子、室原豊明、永田浩三

第41回日本高血圧学会総会 

PTEN阻害薬は脾臓の免疫応答の抑制を介してメタボリックシンドロームラットの皮下脂肪炎症を抑制する（JSH/SHR合同企画・優秀演題候補発表）

内仲彩子、河合夢乃、小室佳奈子、藤枝愛生、綿谷美南、米田護、小松優希、青山清志、中野志保、芦川采央、室原豊明、永田浩三

第41回日本高血圧学会総会 

ミート・ザ：エキスパート3「Looking Back on My Life in Boston」 Invited

第66回日本心臓病学会学術集会 

シンポジウムI-3「次世代リーダーを育成するための臨床検査技師教育のあるべき姿とそれに向けた取り組み―国立大学の立場から」 Invited

永田浩三

第13回日本臨床検査学教育学会学術大会 

Pharmacological inhibition of phosphatase and tensin homolog ameliorates adipose tissue inflammation and increases splenic regulatory B and T cells in rats with metabolic syndrome International conference

Ayako Uchinaka, Yumeno Kawai, Kanako Komuro, Aoi Fujieda, Minami Wataya, Mamoru Yoneda, Yuki Komatsu, Kiyoshi Aoyama, Toyoaki Murohara, Kohzo Nagata

The Basic Cardiovascular Sciences 2018 Scientific Sessions 

Heat-killed Lactobacillus plantarum L-137 Attenuates Cardiac and Adipose Tissue Pathology via Enhanced Splenic Treg Cells in Rats with Metabolic Syndrome

Ayako Uchinaka, Naoki Azuma, Hisashi Mizumoto, Shiho Nakano, Moeko Minamiya, Mamoru Yoneda, Kiyoshi Aoyama, Yuki Komatsu, Yuichiro Yamada, Toyoaki Murohara, Kohzo Nagata

The 82th Annual Scientific Meeting of the Japanese Circulation Society (JCS2018) 

Surgical Removal of Subcutaneous Adipose Tissue Alleviates Salt-exacerbated Cardiac and Adipose Tissue Pathology in Rats with Metabolic Syndrome

Kiyoshi Aoyama, Ayako Uchinaka, Yuki Komatsu, Mamoru Yoneda, Naoki Azuma, Shiho Nakano, Hisashi Mizumoto, Moeko Minamiya, Toyoaki Murohara, Kohzo Nagata

The 82th Annual Scientific Meeting of the Japanese Circulation Society (JCS2018) 

Obesity-induced Whitening of Brown Adipose Tissue Exacerbates Myocardial Pathology in Salt-loaded Rats with Metabolic Syndrome

Yuki Komatsu, Ayako Uchinaka, Kiyoshi Aoyama, Mamoru Yoneda, Hiroko Ohya, Mika Ikeguchi, Shogo Ito, Yusuke Sano, Yuichiro Yamada, Toyoaki Murohara, Kohzo Nagata

The 82th Annual Scientific Meeting of the Japanese Circulation Society (JCS2018) 

Effects of splenectomy on cardiac and adipose tissue pathology in salt-loaded rats with metabolic syndrome International conference

Mamoru Yoneda, Ayako Uchinaka, Kiyoshi Aoyama, Yuuki Komatsu, Naoki Azuma, Shiho Nakano, Moeko Minamiya, Hisashi Mizumoto, Yuichiro Yamada, Ikumi Honda, Toyoaki Murohara, Kohzo Nagata

The 2018 Angiotensin Gordon Research Conference 

食塩負荷したメタボリックシンドロームラットにおいて褐色脂肪組織の摘出は心筋の炎症と線維化を抑制する

小松優希、大矢寛子、青山清志、池口未華、米田護、伊藤彰吾、佐野裕介、山田雄一郎、内仲彩子、室原豊明、永田浩三

第40回日本高血圧学会総会 

メタボリックシンドローム、心血管病と食塩 Invited

永田浩三

第40回日本高血圧学会総会 会長特別企画5「高血圧のトランスレーショナルリサーチ」 

メタボリックシンドロームラットにおける脾臓摘出は、食塩負荷により増悪した心臓および脂肪組織病変を改善する

米田護、内仲彩子、青山清志、小松優希、東直希、中野志保、南谷萌子、水本尚志、　 山田雄一郎、本田育美、室原豊明、永田浩三

第40回日本高血圧学会総会 

Effects of the mTOR inhibitor everolimus on cardiac and adipose tissue pathology and glucose metabolism in rats with metabolic syndrome

Ayako Uchinaka, Mamoru Yoneda,Yuichiro Yamada, Toyoaki Murohara, Kohzo Nagata

The 81th Annual Scientific Meeting of the Japanese Circulation Society (JCS2017) 

EtanerceptによるTNF-α阻害は食塩負荷したメタボリックシンドロームラットの心筋傷害を改善するが、インスリン抵抗性と脂肪炎症には影響しない

米田護、内仲彩子、柴田萌乃、福間麻未、伊藤彰吾、佐野裕介、長澤快、松浦菜摘、山田雄一郎、本田育美、室原豊明、永田浩三

第39回日本高血圧学会総会 

Ramelteon attenuates cardiac injury, improves insulin signaling in white adipose tissue, and attenuates whitening of brown adipose tissue in rats with metabolic syndrome International conference

Ayako Uchinaka, Yuri Kawashima, Yuki Sano, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Kai Nagasawa, Natsumi Matsuura, Yuichiro Yamada, Toyoaki Murohara, Kohzo Nagata

The 26th Scientific Meeting of the International Society of Hypertension (Young Investigator Award, Bronze) 

食塩感受性高血圧ラットに対するL/N型カルシウム拮抗薬の晩期投与の拡張期心不全抑制効果の検討

米田護、青山清志、池口未華、伊藤彰吾、佐野裕介、山田雄一郎、内仲彩子、本田育美、室原豊明、永田浩三

第11回日本臨床検査学教育学会学術大会 

Atorvastatin attenuates cardiac and adipose inflammation via adiponectin-independent activation of AMPK and inhibition of NF-κB in rats with metabolic syndrome

第80回日本循環器学会学術集会 

食塩負荷したメタボリックシンドロームラットにおいて脂肪分解阻害は脂肪炎症とp53発現を抑制するとともにインスリン抵抗性を改善する

伊藤彰吾、佐野裕介、松浦菜摘、長澤快、山田雄一郎、渡辺彰吾、室原豊明、永田浩三

第38回日本高血圧学会総会 

メタボリックシンドロームラットにおいて食塩負荷による心筋冠血管形成の低下とインスリン抵抗性の増大にはp53の活性化が関与する

佐野裕介、伊藤彰吾、松浦菜摘、長澤快、山田雄一郎、渡辺彰吾、室原豊明、永田浩三

第38回日本高血圧学会総会 

Atorvastatin ameliorates cardiac injury and inflammation via adiponectin-independent activation of AMP-activated protein kinase and inhibition of the NF-κB pathway in rats with metabolic syndrome International conference

Yuichiro Yamada, Shino Takeuchi, Shogo Watanabe, Yuji Minagawa, Shogo Ito, Yusuke Sano, Kai Nagasawa, Natsumi Matsuura, Toyoaki Murohara, Kohzo Nagata

American Heart Association, Council on Hypertension 2015 Scientific Sessions 

メタボリックシンドロームラットにおいて食塩負荷によるインスリン抵抗性、脂質異常症および心筋傷害の増悪には脂肪分解と炎症が関与する

伊藤彰吾、佐野裕介、松浦菜摘、長澤快、山田雄一郎、渡辺彰吾、室原豊明、永田浩三

第10回日本臨床検査学教育学会学術大会 

Inhibition of P53 ameliorates salt-induced enhancement of hypertension and cardiac and adipose tissue pathology in rats with metabolic syndrome

第79回日本循環器学会学術集会 

Inhibition of lipolysis attenuates hypertension and cardiac and adipose tissue pathology in salt-loaded rats with metabolic syndrome

第79回日本循環器学会学術集会 

Elevated C-reactive protein levels and enhanced high frequency vasomotion in patients with ischemic heart disease during brachial flow-mediated dilation International conference

Shogo Watanabe, Eisuke Amiya, Masafumi Watanabe, Munenori Takata, Kohzo Nagata, Ryozo Nagai, Issei Komuro

The 31st Annual Meeting of the International Society for Heart Research Japanese Section 

Effects of pioglitazone on cardiac and adipose tissue pathology and glucose metabolism in a rat model of metabolic syndrome International conference

Natsumi Matsuura, Chiharu Asano, Kai Nagasawa, Shogo Ito, Yusuke Sano, Yuji Minagawa, Yuichiro Yamada, Takuya Hattori, Shogo Watanabe, Toyoaki Murohara, Kohzo Nagata

2014 Nagoya-Yonsei University Research Exchange Meeting on Health Sciences 

ラットにおける麻酔薬の血行動態、心機能、および糖脂質代謝に及ぼす影響の検討

佐野裕介、伊藤彰吾、新井りほ、神谷美聡、長澤快、松浦菜摘、山田雄一郎、服部拓哉、渡辺彰吾、坂東泰子、室原豊明、永田浩三

第37回日本高血圧学会総会 

メタボリックシンドロームラットモデルにおけるエイコサペンタエン酸の心筋および脂肪組織の病態生理に及ぼす影響の検討

伊藤彰吾、佐野裕介、新井りほ、神谷美聡、長澤快、松浦菜摘、山田雄一郎、服部拓哉、渡辺彰吾、室原豊明、永田浩三

第37回日本高血圧学会総会 

Dahl食塩感受性高血圧ラットの拡張性心不全に対するL/N型Ca拮抗薬の抑制効果の検討：皆川雄治、鈴木杏、中川真穂、武内紫乃、伊藤彰吾、佐野裕介、長澤快、松浦菜摘、大浦彩依、竹下侑里、山田雄一郎、服部拓哉、渡邊彰吾、室原豊明、永田浩三

皆川雄治、鈴木杏、中川真穂、武内紫乃、伊藤彰吾、佐野裕介、長澤快、松浦菜摘、大浦彩依、竹下侑里、山田雄一郎、服部拓哉、渡邊彰吾、室原豊明、永田浩三

第37回日本高血圧学会総会 

メタボリックシンドロームラットにおける拘束ストレスの心筋と脂肪組織の病態および代謝異常に及ぼす影響の検討：交感神経βアドレナリン受容体の役割

松浦菜摘、長澤快、皆川雄治、伊藤彰吾、佐野裕介、大浦彩依、竹下侑里、山田雄一郎、服部拓哉、渡辺彰吾、室原豊明、永田浩三

第37回日本高血圧学会総会 

The glucocorticoid receptor antagonist RU486 ameliorates cold stress-induced exacerbation of cardiac and adipose tissue pathology and metabolic disorders in a rat model of metabolic syndrome International conference

Kai Nagasawa, Natsumi Matsuura, Yuji Minagawa, Shogo Ito, Yusuke Sano, Yuichiro Yamada, Takuya Hattori, Shogo Watanabe, Toyoaki Murohara, Kohzo Nagata

American Heart Association, High Blood Pressure Research (HBPR) 2014 Scientific Sessions 

メタボリックシンドロームラットにおける拘束ストレスの心筋傷害、体脂肪および糖代謝異常に及ぼす影響：交感神経βアドレナリン受容体の役割

松浦菜摘、長澤快、皆川雄治、伊藤彰吾、佐野裕介、山田雄一郎、服部拓哉、渡辺彰吾、室原豊明、永田浩三

第9回日本臨床検査学教育学会学術大会 

Electrically induced mechanomyogram can directly evaluate the diaphragmatic contractility in young and elderly subjects International conference

Shogo Watanabe, Ippei Nojima, Yuuna Agarie, Tatsunori Watanabe, Kohzo Nagata

The American Thoracic Society's 2014 International Conference (ATS 2014) 

Restraint stress attenuates obesity and deteriorates cardiac and adipose tissue pathology via β-adrenergic receptors in rats with metabolic syndrome

第78回日本循環器学会学術集会 

Glucocorticoid receptor blockade ameliorates cold stress-induced exacerbation of cardiac and adipose tissue pathology in a rat model of metabolic syndrome

第78回日本循環器学会学術集会 

RU486を用いたグルココルチコイド受容体遮断はメタボリックシンドロームラットの脂肪組織炎症と心筋傷害を軽減する

竹下 侑里、高橋 圭司、大浦 彩依、松浦 菜摘、長澤 快、服部 拓哉、渡辺彰吾、伊藤 裕美、室原 豊明、永田 浩三

第36回日本高血圧学会総会 

mTOR阻害薬のエベロリムスはメタボリックシンドロームラットの心筋傷害及び脂肪組織炎症を軽減する

大浦 彩依、高橋 圭司、竹下 侑里、松浦 菜摘、長澤 快、服部 拓哉、伊藤 裕美、渡辺彰吾、室原 豊明、永田 浩三

第36回日本高血圧学会総会 

新規メタボリックシンドロームラットモデルを用いたpioglitazoneの心筋傷害及び体脂肪に及ぼす影響の検討

松浦菜摘、浅野智晴、服部拓哉、高津美和、高橋圭司、大浦彩依、竹下侑里、長澤快、渡辺彰吾、室原豊明、永田浩三

第36回日本高血圧学会総会 

Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome International conference

Takuya Hattori, Tamayo Murase, Miwa Takatsu, Sae Ohura, Yuuri Takeshita, Keiji Takahashi, Toyoaki Murohara, Kohzo Nagata

American Heart Association, High Blood Pressure Research 2013 Scientific Sessions 

Generation of induced pluripotent stem cells using rat mesenchymal stromal cells originated from a new model of metabolic syndrome International conference

Nana Ninagawa Takenaka, Mami Kobayashi, Yuka Kawabata, Kohzo Nagata, Shigeko Torihashi

The 11th Annual Meeting of International Society for Stem Cell Research 

アルドステロン研究から考える心肥大合併高血圧の治療

永田浩三、佐野元昭、藤田敏郎

循環器疾患とアルドステロン座談会 

Comparative effects of cilnidipine and amlodipine, added to valsartan, on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats

第77回日本循環器学会学術集会 

Dietary salt restriction ameliorates cardiac pathology and insulin resistance independently of obesity in a rat model of metabolic syndrome International conference

Takuya Hattori, Tamayo Murase, Miwa Takatsu, Sae Ohura, Yuuri Takeshita, Keiji Takahashi, Hiromi Ito, Toyoaki Murohara, Kohzo Nagata

The 29th Annual Meeting of the International Society for Heart Research Japanese Section 

Dahl食塩感受性ラットにおけるアンジオテンシン受容体拮抗薬とL/N型Ca拮抗薬の併用投与による心保護効果の検討

高橋圭司、高津美和、長澤快、若松亜弥、中島千恵子、大浦彩依、竹下侑里、服部拓哉、伊藤裕美、室原豊明、永田浩三

第35回日本高血圧学会総会 

新規メタボリック症候群ラットモデルにおいて酸化ストレスとミネラロコルチコイド受容体が左室リモデリングと拡張障害に関与する

高橋圭司、村瀬珠代，稲垣莉代，鈴木英里奈，高津美和，中島千恵子，大浦彩依，竹下侑里，服部拓哉，大嶽正文，伊藤裕美，室原豊明，永田浩三

第7回日本臨床検査学教育学会学術大会 

新規メタボリック症候群ラットモデルの左室リモデリングと拡張障害に心筋酸化ストレスとミネラロコルチコイド受容体の活性化が関与する

高橋圭司、高津美和、稲垣莉代、鈴木英里奈、村瀬珠代、服部拓哉、中島千恵子、大嶽正文、室原豊明、永田浩三

第1回臨床高血圧フォーラム 

Involvement of Oxidative Stress and Mineralocorticoid Receptors in Cardiac Pathology in a New Rat Model of Metabolic Syndrome

第76回日本循環器学会学術集会 

Comparative effect of amlodipine and cilnidipine on cardiac remodeling and diastolic function in Dahl salt-sensitive rats International conference

Miwa Takatsu, Takuya Hattori, Tamayo Murase, Masafumi Ohtake, Miki Kato, Keigo Nashima, Chieko Nakashima, Keiji Takahashi, Kazumi Niinuma, Shizuka Aritomi, Toyoaki Murohara, Kohzo Nagata

2011 Yonsei-Nagoya University Research Exchange Meetings in Health Sciences & Nursing 

新規メタボリック症候群ラットモデルにおけるカロリー制限の心血管効果

高津美和、中島千恵子、服部拓哉、村瀬珠代、高橋圭司、室原豊明、永田浩三

第34回日本高血圧学会総会 

新規メタボリック症候群ラットモデルの心筋傷害における酸化ストレスとミネラロコルチコイド受容体の関与の検討

高橋圭司、村瀬珠代、稲垣莉代、鈴木英里奈、服部拓哉、高津美和、中島千恵子、大嶽正文、室原豊明、永田浩三

第34回日本高血圧学会総会 

Dietary salt restriction ameliorates cardiac pathology independently of obesity in a rat model of metabolic syndrome International conference

Kohzo Nagata

The 4th international aldosterone forum in Japan (IAF-J) 

Comparative Effect of Amlodipine and Cilnidipine on Cardiac Remodeling and Diastolic Function in Dahl Salt-Sensitive Rats

第75回日本循環器学会総会・学術集会 

The Effects of Estrogen on Cardiovascular Injury in Ovariectomized Female DahlS.Z-Leprfa/Leprfa Rats as a New Rat Model of Metabolic Syndrome

第75回日本循環器学会総会・学術集会 

Dahl食塩感受性ラットの心筋リモデリングに対するL/N型Ca拮抗薬の効果の検討

高津美和、服部拓哉、加藤実希、奈島圭吾、村瀬珠代、大嶽正文、加藤洋介、室原豊明、永田浩三

第33回日本高血圧学会総会 

メタボリック症候群ラットモデルにおける血圧および心筋傷害に対する食塩摂取制限の効果の検討

服部拓哉、高津美和、村瀬珠代、大嶽正文、加藤洋介、室原豊明、永田浩三

第33回日本高血圧学会総会 

メタボリック症候群ラットモデルDahlS.Z-Leprfa/ Leprfaにおける心筋リモデリングと拡張機能障害

村瀬珠代、服部拓哉、高津美和, 阿部 麻由奈、天草結衣、加藤洋介、室原豊明、永田浩三

第14回日本心不全学会学術集会 

Mechanism for the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertension International conference

Kohzo Nagata, Yuichiro Yamada, Koji Tsuboi, Takuya Hattori, Tamayo Murase, Masafumi Ohtake, Toyoaki Murohara, Yasuo Koike

23rd Scientific Meeting of the International Society of Hypertension 

Glucocorticoids activate cardiac mineralocorticoid receptors in adrenalectomized Dahl salt-sensitive rats International conference

Kohzo Nagata, Masafumi Ohtake, Masafumi Sakai, Tamayo Murase, Takuya Hattori, Mayuko Furukawa, Masaaki Miyachi, Xian Wu Cheng, Toyoaki Murohara, Yasuo Koike

XXth World Congress of the International Society for Heart Research 2010 Kyoto 

Micro RNAs could be Key Molecules for Impaired Adrenergic Myocardial Contractile Reserve in Patients with Idiopathic Dilated Cardiomyopathy

第74回日本循環器学会総会・学術集会 

Establishment of a New Animal Model of Metabolic Syndrome: DahlS.Z-Leprfa/Slc

第74回日本循環器学会総会・学術集会 

Cardiac Remodeling and Diastolic Dysfunction in DahlS.Z-Leprfa/Slc Rats as a New Rat Model of Metabolic Syndrome

第74回日本循環器学会総会・学術集会 

グルココルチコイド誘導性高血圧と心筋傷害のメカニズムの検討

村瀬珠代、永田浩三、服部拓哉、酒井雅史、大嶽正文、横田充弘、室原豊明、古池保雄

第13回日本心不全学会学術集会 

Glucocorticoid-Induced Hypertension, Cardiac Remodeling, and Diastolic Dysfunction in Adrenalectomized Dahl Salt-Sensitive Rats

永田浩三、大嶽正文、加藤まゆ子、坪井公司、山田雄一郎、井上千沙、村瀬珠代、服部拓哉、西澤孝夫、横田充弘、室原豊明、古池保雄

第73回日本循環器学会総会・学術集会 プレナリーセッション⑤「食塩と高血圧」 

Relation of Functional and Morphological Changes in Mitochondria to Myocardial Contractile and Relaxation Reserves in Asymptomatic to Mildly Symptomatic Patients with Hypertrophic Cardiomyopathy. International conference

American Heart Association, Scientific Sessions 2008, New Orleans, Louisiana 

Combined Effects of Losartan and Hydrochlorothiazide on Cardiac Remodeling and Function in Dahl Salt-Sensitive Hypertensive Rats. International conference

American Heart Association, Scientific Sessions 2008, New Orleans, Louisiana 

Pioglitazone Attenuates Angiotensin II-Induced Cardiac Hypertrophy and Fibrosis Through Stimulation of Adiponectin Secretion. International conference

American Heart Association, Scientific Sessions 2008, New Orleans, Louisiana 

Exercise Training Alters Left Ventricular Geometry and Improves Heart Failure in Dahl Salt-Sensitive Hypertensive Rats: Role of PI3K p110α/γ-Akt-mTOR-Mediated Activation of Proangiogenic Signaling. International conference

American Heart Association, Scientific Sessions 2008, New Orleans, Louisiana 

Reduced [123I]metaiodobenzylguanidine Uptake Pedicts Impaired Adrenergic Myocardial Functional Reserve in Asymptomatic or Mildly Symptomatic Patients with Idiopathic Dilated Cardiomyopathy. International conference

American Heart Association, Scientific Sessions 2008, New Orleans, Louisiana 

Mineralocortcoid receptor blockade attenuates cardiac hypertrophy and failure in low-renin, low-aldosterone hypertensive rats. International conference

The 1st international aldosterone forum in Japan (IAF-J), Tokyo 

Dobutamine-induced Mechanical Alternans Predicts Poor Prognosis In Mildly To Moderately Symptomatic Patients With Idiopathic Dilated Cardiomyopathy In Sinus Rhythm. International conference

American Heart Association, Scientific Sessions 2007, Orlando, Florida 

Minor Myocardial Damage and LV Dysfunction in Patients with Duchenne Muscular Dystrophy-The Preventive Efficacy of Carvedilol on Plasma Cardiac Troponin I. International conference

American Heart Association, Scientific Sessions 2007, Orlando, Florida 

Azelnidipine Enhances Beneficial Effects of Olmesartan on Left Ventricular Remodeling During the Development of Hypertension-induced Heart Failure. International conference

American Heart Association, Scientific Sessions 2007, Orlando, Florida 

The Ca2+ Channel Blocker Benidipine Promotes Coronary Angiogenesis And Reduces Both Left Ventricular Stiffness And Mortality In Hypertensive Rats. International conference

American Heart Association, Scientific Sessions 2007, Orlando, Florida 

A Randomized, Open-label, Crossover Pilot Study Comparing The Effects Of A Loop Diuretic With Antialdosteronergic Properties Versus A Pure Loop Diuretic On Activation Of Sympathetic Nerve System In Mildly Symptomatic Patients With Chronic Heart Failure. International conference

American Heart Association, Scientific Sessions 2007, Orlando, Florida 

Myocardial Microvasculature Dysfunction and Impaired Left Ventricular Relaxation Revealed by Ultrasonic Strain Rate in Patients with Obstructive Sleep Apnea Syndrome. International conference

American Heart Association, Scientific Sessions 2007, Orlando, Florida 

Superoxide-Dependent Cathepsin Activation System is Associated with Hypertensive Myocardial Remodeling and Represents a Target for Angiotesin II Type 1 Receptor Blocker Therapy. International conference

American Heart Association, Scientific Sessions 2007, Orlando, Florida 

ミネラロコルチコイド受容体拮抗薬は低アルドステロン性高血圧ラットにおいて心肥大・心不全を抑制する

永田浩三、小畑孝二、許京欄、加藤まゆ子、宮地正朗、矢澤宏樹、坪井公司、山田高資、西澤孝夫、野田明子、成憲武、井澤英夫、室原豊明、古池保雄、横田充弘

第24回日本心電学会学術集会　シンポジウムI：学術諮問委員会提言シンポジウム 

Cardiac Myolysis and LV Dysfunction in Patients with Duchenne Muscular Dystrophy: Inhibitory Effect of Carvedilol on Cardiac Myolysis. International conference

American Collage of Cardiology, 56th Annual Scientific Session 

Protective Effects of a Novel Long-Acting Calcium Channel Blocker Azelnidipine Against Cardiac Hypertrophy and Failure in Dahl Salt-Sensitive Rats. International conference

American Collage of Cardiology, 56th Annual Scientific Session 

The Molecular Mechanism of Calcium Antagonists for the Prevention of Heart Failure. International conference

The 1st International Congress of Cardiomyopathies and Heart Failure, Morning Satellite Program 

Contractile Reserve Revealed by β1-Adrenergic Stimulation as a Predictor of Altered Myocardial Expression of Contractile Regulatory Proteins in Mildly Symptomatic Patients with Idiopathic Dilated Cardiomyopathy. International conference

American Heart Association, Scientific Sessions 2006 

A Elastolytic Cathepsin Induction/Activation System Exists in the Rat and Human Myocardium and is Upregulated in Hypertensive Heart Failure. International conference

American Heart Association, Scientific Sessions 2006 

Left Ventricular Diastolic Dyssynchrony Derived from Strain Rate Imaging is Related to Impaired Relaxation and Increased Stiffness in Patients with Dilated Cardiomyopathy. International conference

American Heart Association, Scientific Sessions 2006 

Mineralocortcoid Receptor Blockade Attenuates Cardiac Hypertrophy and Failure in Low-Renin, Low-Aldosterone Hypertensive Rats. International conference

ISH symposium for Aldosterone and Hypertension 

Mineralocortcoid Receptor Blockade Attenuates Cardiac Hypertrophy and Failure in Low-Renin, Low-Aldosterone Hypertensive Rats. International conference

ISH2006 POST CONGRESS IN NAGOYA, International Symposium “Salt, Other Minerals and Hypertension" 

Mineralocortcoid Receptor Blockade Attenuates Cardiac Hypertrophy and Failure in Low-Renin, Low-Aldosterone Hypertensive Rats. International conference

The 21st Scientific Meeting of the International Society of Hypertension 

Mineralocorticoid receptor antagonist added to angiotensin-converting enzyme inhibitor ameliorates the transition to diastolic heart failure by decreasing myocardial oxidative stress. International conference

American Heart Association, Scientific Sessions 2005, Dallas, Texas. 

Profound functional and structural cardiovascular alterations induced by endotoxin derived from Pseudomonas aeruginosa. International conference

The 8th Conference of the International Endotoxin Society, Kyoto. 

Mineralocorticoid receptor antagonism inhibits the development of cardiac hypertrophy and prevents the transition from hypertrophy to failure in low-renin and low-aldosterone hypertension. International conference

American Heart Association, Scientific Sessions 2004, Chicago, Illinois. 

Cardiovascular effects of endotoxin derived from Escherichia coli vs. Klebsiella pneumoniae. International conference

The 8th Conference of the International Endotoxin Society, Kyoto. 

Relationship Between MIBG Finfings and Myocardial Properties in Patients with Dilated Cardiomyopathy. International conference

The Society of Nuclear Medicine, 51st Annual Meeting, Philadelphia. 

Myocardial 123I-MIBG Scintigraphy Can Assess Left Ventricular Functional Reserve in Patients with Nonobstructive Hypertrophic Cardiomyopathy. International conference

The Society of Nuclear Medicine, 51st Annual Meeting, Philadelphia. 

Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect. International conference

Keystone Symposia, Molecular Biology of Cardiac Disease, Keystone, Colorado. 

Statin therapy can improve cardiac function and survival after heart failure in rats. International conference

American Collage of Cardiology, 53rd Annual Scientific Sessions, New Orleans, Louisiana. 

Growth hormone-releasing peptide can suppress myocardial oxidative stress and ameliorate progressive left ventricular remodeling in cardiomyopathic hamsters. International conference

American Collage of Cardiology, 53rd Annual Scientific Sessions, New Orleans, Louisiana. 

Blunted β-adrenergic response is associated with changes in Gs protein pathway in hypertension-induced LV hypertrophy of Dahl salt-sensitive rats. International conference

American Heart Association, 71st Annual Scientific Sessions, Dallas, Texas. 

Beta-adrenergic desensitization occurs in compensated LV hypertrophy of Dahl salt-sensitive rats. International conference

American Heart Association, 70th Annual Scientific Sessions, Orland, Florida. 

Doppler assessment of early diastolic filling changes induced by positive inotropic agents in patients with dilated cardiomyopathy. International conference

American Heart Association, 66th Annual Scientific Sessions, Atlanta, Georgia. 

食塩感受性高血圧ラットの拡張性心不全に対するL/N型Ca拮抗薬の抑制効果の検討

2013.10 - 2014.12

国内共同研究 

在宅医療・訪問看護に活用できる経時評価用ポータブル腸電位計の開発

2014.4 - 2015.3

第26回東海産業技術振興財団研究助成金（研究育成型） 

新規メタボリックシンドロームラットモデルにおけるラメルテオンの基本病態および臓器障害に及ぼす影響

2015.1 - 2015.12

平成26年度調査研究助成金 

食塩感受性高血圧ラットを用いたL/N型カルシウム拮抗薬の晩期投与の心不全抑制効果の検討：L型カルシウム拮抗薬およびアンジオテンシン変換酵素阻害薬との比較

2015.7 - 2017.6

国内共同研究 

メタボリックシンドロームラットにおけるエベロリムスの心筋傷害および糖代謝への効果の用量関連性の検討

2015.12 - 2017.3

企業からの受託研究 

Dahl食塩感受性ラットに対する腎神経アブレーションの高血圧および腎傷害への影響の検討ーアブレーション実施時期による効果の相違ー

2021.4 - 2022.3

公益財団法人　市原国際奨学財団  研究助成  第29回（2021年度）研究助成

永田　浩三

臨床生理検査学I

2024

解剖学II

2024

生理学II

2024

検査技術科学研究法I

2024

生理学I

2023

生理検査技術開発法

2024

臨床生理検査学実習Ｂ

2024

臨床生理検査学実習Ｃ

2024

検査技術科学特論 II

2024

臨床生理検査学実習Ａ

2024

オミックス医療科学実習Ⅰ

2024

特別研究

2024

病態生理学概論

2024

生体情報解析学実習

2024

臨床病理学演習

2024

保健薬理学

2024

日本学術振興会 科学研究費委員会専門委員 第１段審査（書面審査）

2014.12 - 2016.11

名城大学附属高等学校SGH運営指導委員会委員

Role(s)：Appearance,　Organizing member

2014.7 - 2015.3

名城大学附属高等学校SSH運営指導委員会委員

Role(s)：Organizing member

2013.6 - 2016.3

名城大学附属高等学校学校評議員

Role(s)：Organizing member

2012.4 - 2020.3