研究者詳細 - 川部　勤

講演・口頭発表等 - 川部　勤

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Mini-Symposium, Evaluation of Th1-Type Cytokines and Chemokines as Diagnostic Markers of Tuberculous Pleural Effusions. 国際会議

Kawabe T, Okamoto M, Hara T, Hashimoto N, Imaizumi K, Hasegawa Y, Takagi K, Shimokata K

ATS 2005 San Diego, International Conference, American Thoracic Society 100 Anniversary

Th1/Th2 Chemokine Expression in Non-Small Cell Lung Cancer Tissue: Increased Expression of CCL22 (MDC) May Be Associated with Better Prognosis 国際会議

Imaizumi K, Nakanishi T, Kawabe T, Okamoto M, Ito G, Hashimoto N, Sumida A, Kojima K, Sekido Y, Ito Y, Kume H, Hasegawa Y, Shimokata K

ATS 2005 San Diego, International Conference, American Thoracic Society 100 Anniversary

肺線維症の病態形成における骨髄由来細胞の関与

橋本直純、川部　勤、今泉和良、長谷川好規、下方　薫

第9回Acute Lung Injury研究会

肥満細胞におけるフラボノイドの抗アレルギー作用の検討

松島充代子、川部　勤、青山真梨子、田中成一、長谷川高明、高木健三

第17回気道病態シンポジウム

結核性及び癌性胸膜炎におけるサイトカイン

岡本真和、川部　勤、原　徹、伊藤　康、今泉和良、久米裕明、長谷川好規、高木健三、下方　薫

第54回日本アレルギー学会総会

SMXAリコンビナント近交系マウスを用いた気管支喘息の原因遺伝子の同定と解析

岡本真和、川部　勤、原　徹、伊藤　康、今泉和良、久米裕明、長谷川好規、高木健三、下方　薫

第16回日本アレルギー学会春季臨床大会

結核性胸膜炎におけるサイトカインの動態

岡本真和、川部　勤、原　徹、伊藤　康、今泉和良、久米裕明、長谷川好規、高木健三、下方　薫

第74回実験結核研究会

ヒト気道上皮細胞におけるCa2+依存性K+チャネルを介した細胞外ATP受容体刺激のメカニズム

伊藤　康、孫　政実、佐藤慎二、石川貴之、近藤征史、川部　勤、今泉和良、長谷川好規、下方　薫

第44回日本呼吸器学会学術講演会

肺癌組織および肺癌細胞株におけるTh1細胞遊走性ケモカイン発現の解析

中西　亨、今泉和良、川部　勤、岡本真和、伊藤源士、住田　篤、小島克之、伊藤　康、久米裕明、関戸好孝、長谷川好規、下方　薫

第44回日本呼吸器学会学術講演会

SMXAリコンビナント近交系マウスを用いたアレルギー遺伝子の同定と解析

岡本真和、川部　勤、長谷川好規、大野民生、西村正彦、高木健三

第16回気道病態シンポジウム

Involvement of lipid rafts on Nrf2 activation induced by quercetin

Matsushima Miyoko, Nose Haruka, Kusatsugu Yuto, Atsumi Kazuko, Sasou Kanako, Tanaka Kyohka, Sugiyama Tomoshi, Ohdachi Tomoko, Hashimoto Naozumi, Kawabe Tsutomu

Proceedings for Annual Meeting of The Japanese Pharmacological Society 2018年 Japanese Pharmacological Society

記述言語：英語会議種別：ポスター発表

<p>Quercetin is one of the flavonoids and has a wide variety of cytoprotective effects. We previously reported that quercetin exerted various cytoprotective effects via nuclear factor E2-related factor 2 (Nrf2)-heme oxygenase (HO)-1 pathway. However, the mechanisms how quercetin can induce HO-1 to exhibit cytoprotective effects are poorly understood. We focused on cell membrane, which is the front line to interact with extracellular environment and plays an important role in cellular signaling. Recent studies showed that Nrf2 interacted with caveolin-1 (Cav-1), a component of caveolae, to regulate cellular anti-oxidant capacity. In this study, we investigated the involvement of Cav-1 in quercetin-induced HO-1 expression. We showed that quercetin changed the formation of lipid rafts, and the expression level of Cav-1 was decreased in cell membrane and increased in cytosol and nucleus after exposure to quercetin. The expression level of Nrf2 localized in cell membrane was also decreased, and Nrf2 was translocated to cytosol and nucleus. The extent of HO-1 induction by quercetin was as much as that by methyl-beta-cyclodextrin, a cholesterol-depleting agent. These findings suggested that HO-1-dependent cytoprotective effects by quercetin could be mediated through the disruption of lipid rafts, leading Cav-1 and Nrf2 to translocate from cell membrane and to nucleus, followed by HO-1 induction.</p>

DOI： 10.1254/jpssuppl.wcp2018.0_po4-8-38

CiNii Research

MEMS Flow Sensor Capable of Measuring Multi-Vital Signs of Respiration, Heart Rate, and Body Temperature 国際会議

Hasegawa Y., Lee S., Matsushima M., Hasegawa S., Kawabe T., Shikida M.

21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 2021年6月20日 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021

記述言語：英語会議種別：ポスター発表

Multi-vital signs detection; respiration, heart rate, and body temperature from respiration airflow at the mouth was proposed, and three sensors patterns (flow-rate, - direction, and -temperature sensors) were formed on a single MEMS sensor. The small-sized tube type flow sensor was designed and fabricated to apply it the animal experiment, and its detection characteristics were experimentally evaluated. The flow rate sensor output followed the King's equation, and the response time of 50 ms was obtained to confirm the following oscillating breathing airflow measurement. Then, we confirmed that the fabricated sensor can measure the airflow whose temperature changes periodically. Finally, we conducted an animal experiment using rats, and confirmed that the fabricated sensor can measure three vital signs of respiration, heart rate, and body temperature from respiration.

DOI： 10.1109/Transducers50396.2021.9495387

Scopus

症状発現に関わるアレルゲンエピトープの探索

小原萌恵子、松島充代子、佐藤光夫、伊藤浩明、川部　勤

第71回日本アレルギー学会学術大会 2022年10月

環境からのストレスに備えるケルセチンによる細胞保護作用の新規機序の検討

都築　光、松島充代子、竹腰正広、谷口ひなた、小原萌恵子、島崎温香、田島歩実、佐藤光夫、川部　勤

第52回日本職業・環境アレルギー学会総会・学術大会 2022年6月

Calibration Method for Wearable Sensor Using Airflow at Mouth for Quantitative Monitoring of Respiration and Heartbeat 国際会議

Horie K., Al Farisi M.S., Hasegawa Y., Matsushima M., Kawabe T., Shikida M.

2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 2023年 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

記述言語：英語会議種別：ポスター発表

Airflow at the mouth contains both the respiration and the heartbeat signals. In this study, we propose a calibration method for a wearable vital sensor attached on the chest using the airflow at the mouth for respiration and heartbeat quantitative monitoring. An artificial ventilator and an experimental animal, namely rat, were introduced as test benches prior to human clinical experiment. As a proof of concept, a micro-electro mechanical systems (MEMS) airflow sensor and a wearable accelerometer were implemented to both the test benches. The velocity output of the piston motion measured by the wearable sensor conformed with the airflow rate output, and the obtained results indicated that the wearable sensor can monitor not only the frequency but also the respiratory volume or heartbeat strength.

Scopus

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講演・口頭発表等 - 川部 勤

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講演・口頭発表等 - 川部　勤