Updated on 2022/04/14

写真a

 
KAWABE, Tsutomu
 
Organization
Graduate School of Medicine Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Professor
Contact information
メールアドレス
External link

Degree 1

  1. 医学博士 ( 名古屋大学 ) 

Research Interests 2

  1. アレルギー性疾患, 呼吸器の診断, 臨床免疫 CD40

  2. 呼吸器の医学, 呼吸器の疾患, 免疫性疾患

Research Areas 3

  1. Others / Others  / Medicine@Medicine in General@Pathological Examination

  2. Others / Others  / Medicine@Pathology@Immunology

  3. Others / Others  / Medicine@Internal Medicine@Internal Medicine Respiratory System

Current Research Project and SDGs 4

  1. ペプチドアレイを用いた新規アレルギー診断法の開発

  2. アレルギー疾患でのCD40分子の役割

  3. 間質性肺炎の病態に関わるサイトカイン・ケモカインの解析

  4. 気管支喘息発症の分子生物学的解析(遺伝因子)

Research History 5

  1. Professor, Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine

    2012.4

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    Country:Japan

  2. Nagoya University   Professor, Innovative Research Center for Preventive Medical Enginnering

    2010.4

  3. 名古屋大学医学部保健学科教授

    2009.4 - 2012.3

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    Country:Japan

  4. 名古屋大学医学部保健学科准教授

    2007.8 - 2009.3

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    Country:Japan

  5. Nagoya University   Researcher

    2006.10

Education 2

  1. Nagoya University   Graduate School, Division of Medicine

    - 1994

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 1987

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    Country: Japan

Professional Memberships 18

  1. 日本内科学会   指導医

    2017.9

  2. 日本内科学会 認定内科専門医   東海支部 評議員

    2010.4

  3. 日本呼吸器学会 専門医 指導医   代議員

    2015.6

  4. 日本アレルギー学会 専門医(指導医)   代議員

    2017.6

  5. 日本アレルギー学会 専門医(指導医)   代議員

    2011.5 - 2013.5

  6. 日本免疫学会   評議員

  7. 日本肺癌学会学会

  8. 日本結核病学会

  9. 日本呼吸器内視鏡学会   東海支部 評議員

    2014.4

  10. 日本職業・環境アレルギー学会   評議員 編集委員

    2015.6

  11. 日本食品免疫学会

  12. European Respiratory Society

  13. Interasma Japan/ North Asia

  14. 日本臨床検査学教育協議会   学術委員会委員

    2021

  15. 名古屋大学医師会   監事

  16. 公益財団法人日本アレルギー協会   理事 東海支部長

  17. 特定非営利活動法人 愛知県COPDネットワーク   監事

  18. Interasma Japan/ North Asia

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Awards 3

  1. 環境大臣表彰(地域環境保全功労者表彰)

    2021.6   環境省  

  2. 愛知県知事表彰

    2018.1   愛知県  

  3. 2000年度アストラゼネカ喘息研究奨励助成

    2000  

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    Country:Japan

 

Papers 127

  1. *SHIP recruitment attenuates FcRIIB -induced B cell apoptosis Reviewed

    Pearse RN, Kawabe T, Bolland S, Guinamard R, Kurosaki T, Ravetch JV

    Immunity   Vol. 10 ( 6 ) page: 753-760   1999.4

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  2. *T cell development in mice lacking all T cell receptor zeta family members (zeta, eta, and FceRI gamma) Reviewed

    Shores EW, Ono M, Kawabe T, Sommers CL, Tran T, Lui K, Udey MC, Ravetch J, Love PE

    J Exp Med   Vol. 187 ( 7 ) page: 1093-1101   1998.4

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  3. *Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity Reviewed

    Kamanaka M, Philipp Yu, Yasui T, Yoshida K, Kawabe T, Horii T, Kishimoto T, Kikutani H

    Immunity   Vol. 4 ( 3 ) page: 275-281   1996.4

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  4. *The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1: , 1994. Reviewed

    Kawabe T, Nara T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T, Kikutani H

    Immunity   Vol. 1 ( 3 ) page: 167-178   1994.4

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  5. Resistance to mutant KRAS<sup>V12</sup>-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line. Reviewed International coauthorship International journal

    Muraki N, Yamada M, Doki H, Nakai R, Komeda K, Goto D, Kawabe N, Matsuoka K, Matsushima M, Kawabe T, Tanaka I, Morise M, Shay JW, Minna JD, Sato M

    Experimental cell research   Vol. 414 ( 1 ) page: 113053   2022.5

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    Mutant KRAS, the most frequently occurring (∼30%) driver oncogene in lung adenocarcinoma, induces normal epithelial cells to undergo senescence. This phenomenon, called “oncogene-induced senescence (OIS)”, prevents mutant KRAS-induced malignant transformation. We have previously reported that mutant KRASV12 induces OIS in a subset of normal human bronchial epithelial cell line immortalized with hTERT and Cdk4. Understanding the mechanism and efficacy of this important cancer prevention mechanism is a key knowledge gap. Therefore, this study investigates mutant KRASV12-induced OIS in upregulated telomerase combined with the p16/RB pathway inactivation in normal bronchial epithelial cells. The normal (non-transformed and non-tumorigenic) human bronchial epithelial cell line HBEC3 (also called “HBEC3KT”), immortalized with hTERT (“T”) and Cdk4 (“K”), was used in this study. HBEC3 that expressed mutant KRASV12 in a doxycycline-regulated manner was established (designated as HBEC3-RIN2). Controlled induction of mutant KRASV12 expression induced partial epithelial-to-mesenchymal transition in HBEC3-RIN2 cells, which was associated with upregulated expression of ZEB1 and SNAIL. Mutant KRASV12 caused the majority of HBEC3-RIN2 to undergo morphological changes; suggestive of senescence, which was associated with enhanced autophagic flux. Upon mutant KRASV12 expression, only a small HBEC3-RIN2 cell subset underwent senescence, as assessed by a senescence-associated β-galactosidase staining (SA-βG) method. Furthermore, mutant KRASV12 enhanced cell growth, evaluated by colorimetric proliferation assay, and liquid and soft agar colony formation assays, partially through increased phosphorylated AKT and ERK expression but did not affect cell division, or cell cycle status. Intriguingly, mutant KRASV12 reduced p53 protein expression but increased p21 protein expression by prolonging its half-life. These results indicate that an hTERT/Cdk4 -immortalized normal bronchial epithelial cell line is partially resistant to mutant KRASV12-induced senescence. This suggests that OIS does not efficiently suppress KRASV12-induced transformation in the context of the simultaneous occurrence of telomerase upregulation and inactivation of the p16/Rb pathway.

    DOI: 10.1016/j.yexcr.2022.113053

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  6. Advancements in MEMS technology for medical applications: Microneedles and miniaturized sensors Reviewed International journal

    Shikida M., Hasegawa Y., Farisi M.S.A., Matsushima M., Kawabe T.

    Japanese Journal of Applied Physics   Vol. 61 ( SA )   2022.1

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    DOI: 10.35848/1347-4065/ac305d

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  7. Miniaturization of Respiratory Measurement System in Artificial Ventilator for Small Animal Experiments to Reduce Dead Space and Its Application to Lung Elasticity Evaluation Reviewed

    Yoshida Homare, Hasegawa Yoshihiro, Matsushima Miyoko, Sugiyama Tomoshi, Kawabe Tsutomu, Shikida Mitsuhiro

    SENSORS   Vol. 21 ( 15 )   2021.8

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    A respiratory measurement system composed of pressure and airflow sensors was introduced to precisely control the respiratory condition during animal experiments. The flow sensor was a hot‐wire thermal airflow meter with a directional detection and airflow temperature change compensation function based on MEMS technology, and the pressure sensor was a commercially available one also produced by MEMS. The artificial dead space in the system was minimized to the value of 0.11 mL by integrating the two sensors on the same plate (26.0 mm × 15.0 mm). A balloon made of a silicone resin with a hardness of A30 was utilized as the simulated lung system and applied to the elasticity evaluation of the respiratory system in a living rat. The inside of the respiratory system was normally pressurized without damage, and we confirmed that the devel-oped system was able to evaluate the elasticity of the lung tissue in the rat by using the pressure value obtained at the quasi‐static conditions in the case of the ventilation in the animal experiments.

    DOI: 10.3390/s21155123

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  8. Fibroblasts positive for meflin have anti-fibrotic property in pulmonary fibrosis. Reviewed

    Nakahara Y, Hashimoto N, Sakamoto K, Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y

    The European respiratory journal     2021.5

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    DOI: 10.1183/13993003.03397-2020

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  9. Micro-machined stent flow sensor for detecting breathing and heartbeat from airflow in airway of rat Reviewed

    Noma H., Hasegawa Y., Matsushima M., Kawabe T., Shikida M.

    Journal of Micromechanics and Microengineering   Vol. 31 ( 2 )   2021.2

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    We developed a stent flow sensor using micro-electromechanical systems (MEMS) technology in order to measure airflow in the airways of laboratory animals. An airflow waveform contains a respiration signal produced by lung motion and heartbeats as these functions are physically connected. This enables both respiration and heart functions to be evaluated under unrestrained and unanesthetized conditions during drug development. Using MEMS technology, we fabricated a tube flow sensor based on a thermal principle, and the stent structure was produced by photolithography and wet etching. The fabricated flow sensor and stent were integrated via a connection area on both elements. In the proof-of-concept trial, we verified that the flow sensor was placed in the center of the tube by expanding the stent. We evaluated the flow detection characteristics, sensor output vs flow rate and sensor response and used the developed stent flow sensor to measure the airflow in the airway of a rat. The respiration and heartbeat signals were successfully identified from the airflow waveform by applying Fourier transform analysis.

    DOI: 10.1088/1361-6439/abd07a

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  10. Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis Reviewed International coauthorship

    Nakahara Y, Hashimoto N, Sakamoto K, Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y

    European Respiratory Journal   Vol. 58 ( 6 ) page: 2003397   2021

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    DOI: 10.1183/13993003.03397-2020.

  11. Development of sensor-probe system with function of measuring flow and pressure for evaluating breathing property at airway in lungs Reviewed

    KAWAMOTO Yuji, MAEDA Yoshihumi, HASEGAWA Yoshihiro, MATSUSHIMA Miyoko, KAWABE Tsutomu, SHIKIDA Mitsuhiro

    Microsystem Technologies     2021

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    DOI: 10.1007/s00542-020-05201-0

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  12. Catheter sensor system for in-situ breathing and optical imaging measurements at airway in inside of lung Reviewed

    MAEDA Yoshihumi, HASEGAWA Yoshihiro, TANIGUCHI Kazuhiro, MATSUSHIMA Miyoko, SUGIYAMA Tomoshi, KAWABE Tsutomu, SHIKIDA Mitsuhiro

    Microsystem Technologies   Vol. 26 ( 12 ) page: 3705 - 3713   2020.12

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    DOI: 10.1007/s00542-020-04843-4

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  13. Involvement of heme oxygenase-1 in suppression of T cell activation by quercetin Reviewed

    Sugiyama Tomoshi, Matsushima Miyoko, Ohdachi Tomoko, Hashimoto Naozumi, Hasegawa Yoshinori, Yokoi Kohei, Kawabe Tsutomu

    Immunopharmacology and immunotoxicology   Vol. 42 ( 4 ) page: 295 - 305   2020.8

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    DOI: 10.1080/08923973.2020.1759623

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  14. Micro-machined respiratory monitoring system development for artificial ventilator in animal experiment Reviewed

    Yoshida Homare, Hasegawa Yoshihiro, Matsushima Miyoko, Sugiyama Tomoshi, Kawabe Tsutomu, Shikida Mitsuhiro

    Microsystem Technologies   Vol. 26 ( 12 ) page: 3715 - 3724   2020.4

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    DOI: 10.1007/s00542-020-04844-3

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  15. Development of micromachined flow sensor for drip infusion system Reviewed

    Shimohira Chihiro, Hasegawa Yoshihiro, Taniguchi Kazuhiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

    Microsystem Technologies   Vol. 26 ( 12 ) page: 3677 - 3683   2020.4

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    DOI: 10.1007/s00542-020-04839-0

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  16. UHRF1, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer Reviewed

    Goto Daiki, Komeda Kazuki, Uwatoko Natsuki, Nakashima Moeka, Koike Mayu, Kawai Kaho, Kodama Yuta, Miyazawa Ayako, Tanaka Ichidai, Hase Tetsunari, Morise Masahiro, Hasegawa Yoshinori, Kawabe Tsutomu, Sato Mitsuo

    Cancer investigation   Vol. 38 ( 4 ) page: 240 - 249   2020.4

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    DOI: 10.1080/07357907.2020.1747483

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  17. Energy-less respiration monitoring device using thermo-sensitive film Reviewed

    Maeda Yoshihumi, Hasegawa Yoshihiro, Taniguchi Kazuhiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

    Microsystem Technologies   Vol. 26 ( 2 ) page: 489 - 497   2020.2

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    DOI: 10.1007/s00542-019-04482-4

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  18. Body temperature measurement based on breathing airflow for continuous monitoring of patient body condition during large scale disasters

    Fujinori Tomohiro, Hasegawa Yoshihiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

      Vol. 25 ( 11 ) page: 4313 - 4321   2019.11

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    DOI: 10.1007/s00542-019-04349-8

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  19. Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research. Reviewed

    Ohno T, Miyasaka Y, Kuga M, Ushida K, Matsushima M, Kawabe T, Kikkawa Y, Mizuno M, Takahashi M

    Experimental animals   Vol. 68 ( 3 ) page: 243-255   2019.8

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    DOI: 10.1538/expanim.18-0185

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  20. A micro-machined flow sensor formed on copper on a polyimide substrate and its application to respiration measurement Reviewed

    Kato Ayami, Hasegawa Yoshihiro, Taniguchi Kazuhiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

    JAPANESE JOURNAL OF APPLIED PHYSICS   Vol. 58 ( SD )   2019.6

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    DOI: 10.7567/1347-4065/ab0dec

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  21. Repressive role of stabilized hypoxia inducible factor 1 alpha expression on transforming growth factor beta-induced extracellular matrix production in lung cancer cells Reviewed

    Ando Akira, Hashimoto Naozumi, Sakamoto Koji, Omote Norihito, Miyazaki Shinichi, Nakahara Yoshio, Imaizumi Kazuyoshi, Kawabe Tsutomu, Hasegawa Yoshinori

    CANCER SCIENCE   Vol. 110 ( 6 ) page: 1959-1973   2019.6

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    DOI: 10.1111/cas.14027

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  22. Wavelength Dependence of Ultrahigh-Resolution Optical Coherence Tomography Using Supercontinuum for Biomedical Imaging Invited Reviewed

    Nishizawa Norihiko, Kawagoe Hiroyuki, Yamanaka Masahito, Matsushima Miyoko, Mori Kensaku, Kawabe Tsutomu

    IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS   Vol. 25 ( 1 )   2019

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    DOI: 10.1109/JSTQE.2018.2854595

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  23. Excretion of Non-volatiles into the Breath and Its Application to Non-invasive Drug Monitoring Invited Reviewed

        page: 534-539   2018.12

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    DOI: 534-539

  24. Analysis of measurement conditions for detecting change in vital signs with catheter flow sensor Reviewed

    Hasegawa Y., Mitsunari Y., Kawaoka H., Matsushima M., Kawabe T., Shikida M.

    JOURNAL OF MICROMECHANICS AND MICROENGINEERING   Vol. 28 ( 10 )   2018.10

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    DOI: 10.1088/1361-6439/aad303

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  25. Catheter type thermal flow sensor with small footprint for measuring breathing function Reviewed

    Y. Hasegawa, H. Kawaoka, Y. Mitsunari, M. Matsushima, T. Kawabe, M. Shikida

    Microsystem Technologies   Vol. 24 ( 8 ) page: 3455 - 3465   2018.8

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    We preivously developed a catheter type flow sensor for measuring breathing and heartbeat information from breathing at the mouth [Hasegawa et al. J Micromech Microeng 27(12): 125016, (2017)
    Kawaoka et al. Tech. Dig. IEEE Micro Electro Mechanical Systems Conference 2016, pp 359–362]. In this study, we redesigned and developed the new sensor configuraiton for the catheter flow sensor to downsize and improve the sensor characteristics. The previous flow sensor consists of two pairs of a heater and a temperature compensation sensor for flow rate detection. The two heaters also functioned not only for flow rate detection but also for flow direction detection. The two temperature compensation sensors had a large footprint and corresponded to each heater. Therefore, the sensor occupied a large area, and it was necessary to match the heater characteristics for flow rate detection. The newly designed sensor is composed of a set of a heater and a temperature compensation sensor and two flow direction sensors. By providing the new flow direction sensors, the number of temperature compensation sensors with a large footprint was reduced to one. Thus, the area of the new sensor design was 15.0 mm2, which was reduced to 54.5% of the 27.0 mm2 of the previous sensor area by providing the flow direction sensors. Then, the new catheter type flow sensor was fabricated, and the flow characteristics for measuring breathing funciton were evaluated. Finally, we applied the catheter type flow sensor to an animal experiment using a rat, and it could evaluate the flow rate characteristics of the rat’s breathing as a reciprocating flow including flow direction. Moreover, the obtained breathing characteristics were within the range of the physiological values of rats.

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  26. Development of tube flow sensor by using film transfer technology and its application to in situ breathing and surface image evaluation in airways

    Chiaki Okihara, Yoshihiro Hasegawa, Miyoko Matsushima, Tsutomu Kawabe, Mitsuhiro Shikida

    Microsystem Technologies   Vol. 24 ( 8 ) page: 3417 - 3424   2018.8

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    A micro-electro-mechanical systems flow sensor was integrated onto an optical fiberscope to enable in situ breathing and surface image evaluations in small airways. The tube flow sensor was developed to be easily attached to an optical fiberscope. Firstly, two heaters working as flow rate sensors were formed on thin film by using a lift-off process. Then the fabricated film sensor was assembled onto the outer tube surface by film transfer technology. The flow rate vs. sensor output characteristics under both the forward and backward flow conditions were confirmed to be coincident. Thanks to thermal capacity reduction by 1.0 μm-thickness film substrate and thermal isolation by cavity formation around the heaters, a short response time of less than 20 ms was obtained. This was sufficient to follow the temporal airflow rate change during breathing. The fabricated tube flow sensor was attached to the outside of a fiberscope 1.6 mm in diameter, and it was inserted into a tube that was connected to the airway of a rat. An optical image of the rat was captured, and its breathing airflow rate was successfully detected.

    DOI: 10.1007/s00542-018-3733-5

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  27. Obstetric factors associated with salivary cortisol levels of healthy full-term infants immediately after birth

    Takahashi Y., Matsushima M., Nishida T., Tanabe K., Kawabe T., Tamakoshi K.

    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY   Vol. 45 ( 6 ) page: 828-832   2018

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    DOI: 10.12891/ceog4088.2018

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  28. Characterization of basket-forceps-type micro-flow-sensor for breathing measurements in small airway Reviewed

    Naoaki Harada, Yoshihiro Hasegawa, Ryota Ono, Miyoko Matsushima, Tsutomu Kawabe, Mitsuhiro Shikida

    Microsystem Technologies   Vol. 23 ( 12 ) page: 5397 - 5406   2017.12

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    We previously proposed a basket-forceps-type flow sensor, in which a flexible thermal flow sensor is mounted onto basket forceps to fix the flow sensor onto the inside surface of the airway. The basket-forceps-type flow sensor has an asymmetrical structure to prevent reciprocating airflow; thus, we investigated the characteristics of the basket-forceps-type flow sensor under both expired- and inspired-airflow conditions in this study. The thermal flow sensor was fabricated on a flexible polyimide film and mounted onto a guide tube of a basket-forceps. Two heaters and their electrical wiring patterns were designed to produce symmetric heat distribution over the heaters. The effects of the basket structure and guide tube on flow-rate measurement were experimentally evaluated, and it was confirmed that they did not affect sensor output. Conversely, sensor output decreased with the increase in tube diameter due to the reduction in the average flow velocity with the diameter increase. Thus, we carried out a procedure to construct a calibration curve under an arbitrary tube diameter. Finally, we applied the basket-forceps-type flow sensor in an animal experiment in which it successfully detected the breathing properties in the airway of a rat.

    DOI: 10.1007/s00542-016-3265-9

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  29. Heartbeat Signal Detection From Analysis of Airflow in Rat Airway Under Different Depths of Anaesthesia Conditions Reviewed

    Hidetaka Kawaoka, Takayuki Yamada, Miyoko Matsushima, Tsutomu Kawabe, Yoshihiro Hasegawa, Mitsuhiro Shikida

    IEEE SENSORS JOURNAL   Vol. 17 ( 14 ) page: 4369 - 4377   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC  

    We inserted a tubular flow sensor incorporating micro-electro-mechanical systems technologies directly into the rat airway and analyzed the airflow waveforms obtained under different depths of anaesthesia conditions by using discrete Fourier transformation (DFT) to evaluate the heartbeat frequency. The electrocardiogram (ECG) signal was used as the reference heartbeat frequency. The calibration curve of the flow sensor used to measure the oscillating airflow in the rat airway was determined on the basis of King's law. The airflow waveform at the rat airway caused by only the heartbeat was measured by applying deep anaesthesia; the waveform frequency coincided with the simultaneously measured ECG signal frequency. DFT analysis of the airflow signals measured under deep and shallow anaesthesia conditions verified the fundamental heartbeat frequency values. The airflow components related to heartbeat motion were successfully extracted by using the heartbeat frequency spectrum. The respiration and heartbeat signals were thus successfully detected.

    DOI: 10.1109/JSEN.2017.2707594

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  30. Development of implantable catheter flow sensor into inside of bronchi for laboratory animal Reviewed

    Mitsuhiro Shikida, Takuya Matsuyama, Takayuki Yamada, Miyoko Matsushima, Tsutomu Kawabe

    Microsystem Technologies   Vol. 23 ( 1 ) page: 175 - 185   2017.1

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    An implantable catheter flow sensor with legs for measuring the breathing characteristics of disease-model animals was developed. The unique feature of this sensor is the use of legs to fix the sensor to the inside wall surface of the air passage without preventing ciliary motion. Differently shaped legs were fabricated by application of a heat shrinkable tube. Prototype sensors was inserted into tubes with inner diameters ranging from 2.4 to 2.7 mm and successfully anchored to the inside surface by the legs. An evaluation of the relationship between the sensor output and the flow rate demonstrated that the sensor output against the flow rate obeyed King's law. The sensor output variation with different inner tube diameters was suppressed to less than 3 %. The developed catheter flow sensor was applied to the breathing measurements in the rat and the rabbit. The breathing waveform obtained from the flow sensor in the rat coincidented to the mechanism of breathing. The sensor was implated into the rabbit bronchus by using a fiberscope, and the breathing characteristics in the bronchus 3 days after implant were successfully measured.

    DOI: 10.1007/s00542-015-2663-8

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  31. Modulation of immunological activity on macrophages induced by diazinon Reviewed

    OGASAWARA Nanako, MATSUSHIMA Miyoko, KAWAMURA Nami, ATSUMI Kazuko, YAMAGUCHI Takehiro, OCHI Haruka, KUSATSUGU Yuto, OYABU Sayaka, HASHIMOTO Naozumi, HASEGAWA Yoshinori, UEYAMA Jun, KAWABE Tsutomu

    Toxicology   Vol. 379   page: 22-30   2017

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    DOI: 10.1016/j.tox.2017.01.014.

  32. Respiration and heartbeat signal detection from airflow at airway in rat by catheter flow sensor with tmeparature compensation function Reviewed

    HASEGAWA Yoshihiro, KAWAOKA Hidenori, YAMADA Takayuki, MATSUSHIMA Miyoko, KAWABE Tsutomu, SHIKIDA Mitsuhiro

    Journal of Micromechanics and Microengineering   Vol. 27   2017

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  33. Exogenous induction of unphosphorylated PTEN reduces TGF beta-induced extracellular matrix expressions in lung fibroblasts Reviewed

    Motohiro Kimura, Naozumi Hashimoto, Masaaki Kusunose, Daisuke Aoyama, Koji Sakamoto, Shinichi Miyazaki, Akira Ando, Norihiro Omote, Kazuyoshi Imaizumi, Tsutomu Kawabe, Yoshinori Hasegawa

    WOUND REPAIR AND REGENERATION   Vol. 25 ( 1 ) page: 86 - 97   2017

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    Transforming growth factor beta (TGF beta) plays an important role in regulating aberrant extracellular matrix (ECM) production from alveolar/epithelial cells (AECs) and fibroblasts in pulmonary fibrosis. Although the tumor suppressor gene phosphatase and tensin homologue deleted from chromosome 10 (PTEN) can negatively control many TGF beta-activated signaling pathways via the phosphatase activity, hyperactivation of the TGF beta-related signaling pathways is often observed in fibrosis. Loss of PTEN expression might cause TGF beta-induced ECM production. In addition, TGF beta was recently shown to induce loss of PTEN enzymatic activity by phosphorylating the PTEN C-terminus. Therefore, we hypothesized that exogenous transfer of unphosphorylated PTEN (PTEN4A) might lead to reduce TGF beta-induced ECM expression in not only epithelial cells but also fibroblasts. Adenovirus-based exogenous PTEN4A induction successfully reduced TGF beta-induced fibronectin expression and retained beta-catenin at the cell membrane in human epithelial cells. Exogenous unphosphorylated PTEN also attenuated TGF beta-induced ECM production and inhibited TGF beta-induced b-catenin translocation in a human fibroblast cell line and in mouse primary isolated lung fibroblasts. Conversely, TGF beta-induced a-smooth muscle actin expression did not seem to be inhibited in these fibroblasts. Our data suggest that exogenous administration of unphosphorylated PTEN might be a promising strategy to restore TGF beta-induced loss of PTEN activity and reduce aberrant TGF beta-induced ECM production from epithelial cells and fibroblasts in lung fibrosis as compared with wild-type PTEN induction.

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  34. Medical Applications Based on MEMS Technologies Reviewed

    SHIKIDA Mitsuhiro, HASEGAWA Yoshihiro, KAWABE Tsutomu, MATSUSHIMA Miyoko

    Journal of The Surface Finishing Society of Japan   Vol. 68 ( 7 ) page: 367 - 372   2017

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    DOI: 10.4139/sfj.68.367

  35. Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers Reviewed

    Takashi Kohnoh, Naozumi Hashimoto, Akira Ando, Koji Sakamoto, Shinichi Miyazaki, Daisuke Aoyama, Masaaki Kusunose, Motohiro Kimura, Norihito Omote, Kazuyoshi Imaizumi, Tsutomu Kawabe, Yoshinori Hasegawa

    CANCER CELL INTERNATIONAL   Vol. 16 ( 1 ) page: 33   2016.4

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    Background: Persistent hypoxia stimulation, one of the most critical microenvironmental factors, accelerates the acquisition of epithelial-mesenchymal transition (EMT) phenotypes in lung cancer cells. Loss of phosphatase and tensin homologue deleted from chromosome 10 (PTEN) expression might accelerate the development of lung cancer in vivo. Recent studies suggest that tumor microenvironmental factors might modulate the PTEN activity though a decrease in total PTEN expression and an increase in phosphorylation of the PTEN C-terminus (p-PTEN), resulting in the acquisition of the EMT phenotypes. Nevertheless, it is not known whether persistent hypoxia can modulate PTEN phosphatase activity or whether hypoxia-induced EMT phenotypes are negatively regulated by the PTEN phosphatase activity. We aimed to investigate hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers.
    Methods: Western blotting was performed in five lung cancer cell lines to evaluate total PTEN expression levels and the PTEN activation. In a xenograft model of lung cancer cells with endogenous PTEN expression, the PTEN expression was evaluated by immunohistochemistry. To examine the effect of hypoxia on phenotypic alterations in lung cancer cells in vitro, the cells were cultured under hypoxia. The effect of unphosphorylated PTEN (PTEN4A) induction on hypoxia-induced EMT phenotypes was evaluated, by using a Dox-dependent gene expression system.
    Results: Lung cancer cells involving the EMT phenotypes showed a decrease in total PTEN expression and an increase in p-PTEN. In a xenograft model, loss of PTEN expression was observed in the tumor lesions showing tissue hypoxia. Persistent hypoxia yielded an approximately eight-fold increase in the p-PTEN/PTEN ratio in vitro. PTEN4A did not affect stabilization of hypoxia-inducible factor 1 alpha. PTEN4A blunted hypoxia-induced EMT via inhibition of beta-catenin translocation into the cytoplasm and nucleus.
    Conclusion: Our study strengthens the therapeutic possibility that compensatory induction of unphosphorylated PTEN may inhibit the acquisition of EMT phenotypes in lung cancer cells under persistent hypoxia.

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  36. Predictors of surgery-induced muscle proteolysis in patients undergoing cardiac surgery Reviewed

    IIDA Yuki, YAMAZAKI Takenori, ARIMA Hajime, KAWABE Tsutomu, YAMADA Sumio

    J Cardiol.   Vol. 68   page: 536   2016

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    DOI: 10.1016/j.jjcc.2015.11.011.

  37. Direct regulation of TGFβ-induced EMT by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells. Reviewed

    KUSUNOSE Masaaki, HASHIMOTO Naozumi, KIMURA Motohiro, OGATA Ryo, AOYAMA Daisuke, SAKAMOTO Koji, MIYAZAKI Shinichi, ANDO Akira, OMOTE Norihiro, IMAIZUMI Kazuyoshi, KAWABE Tsutomu, HASEGAWA Yoshinori

    Cancer Sci.   Vol. 106 ( 12 ) page: 1693 - 1704   2015.12

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  38. Ppm level methane detection using micro-thermoelectric gas sensors with Pd/Al2O3 combustion catalyst films Reviewed

    Nagai Daisuke, Nishibori Maiko, Itoh Toshio, Kawabe Tsutomu, Sato Kazuo, Shin Woosuck

    SENSORS AND ACTUATORS B-CHEMICAL   Vol. 206   page: 488 - 494   2015.1

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    The CH4 combustion performance of a micro-thermoelectric gas sensor (TGS) with Pd-Al2O3 catalysts prepared using two different methods, impregnation and colloid mixing, has been investigated. Three crystal phases of Al2O3, α, θ, and γ, were used for the catalyst support; the Pd/θ-Al2O3 catalyst showed the best combustion performance. The Pd/θ-Al2O3 catalyst exhibited the best dispersion of Pd nanoparticles as analyzed by both a pulse adsorption technique and transmission electron microscopy. The effect of the catalyst thickness on the H2 and CH4 detection performance of the TGS using this Pd/θ-Al2O3 catalyst prepared using a colloid mixing method was investigated. It was found that the response voltage, ΔV, of the TGS to CH4 increased with increasing film thickness, but the ΔV to H2 decreased. The TGS with the Pd/θ-Al2O3 catalyst whose thickness was 35 μm could detect as low as 1 ppm of CH4 in air by the thermoelectric conversion of the combustor heat to an electrical voltage.

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  39. Design and development of a suitable adsorbent to capture theophylline for non-invasive therapeutic drug monitoring with exhaled breath Reviewed

    A. Yamamoto, S. Hioki, C. Tanada, T. Miwa, Y. Inoue, R. Yamamoto, M. Matsushima, T. Kawabe

    ANALYTICAL METHODS   Vol. 7 ( 2 ) page: 423 - 427   2015

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    The possibility of using exhaled breath as a substitute for blood/plasma in areas of therapeutic drug monitoring was investigated. Theophylline was used as a model chemical of non-volatile drugs and the adsorbents suitable for drug capture from exhaled breath were studied. Two macro-porous adsorbents with different monomer compositions were prepared by suspension copolymerization. The capture properties of the synthesized adsorbents and two conventional gas adsorbents packed in a cartridge were evaluated by both aerosol generation and rat expiration. The efficiency of drug capture did not improve by decreasing the pore size and by increasing the specific surface area. A hydrophilic region was found to be necessary for holding the aerosol particles on the adsorbent surface, but a hydrophobic region is also necessary for the adsorption of theophylline. The materials were applied to the intravenous bolus experiment of rats. The amount of theophylline collected from exhaled breath was in the range of 0-0.02 ng min(-1), and it varied similarly to the concentration in blood, which was in the range of 0-37 mu g mL(-1).

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  40. The suppressive effect of quercetin on Toll-like receptor 7-mediated activation in alveolar macrophages. Reviewed

    YASUI Masahiro, MATSUSHIMA Miyoko, OMURA Aya, MORI Kanae, OGASAWARA Nanako, KODERA Yuka, SHIGA Marika, ITO Komei, KOJIMA Seiji, KAWABE Tsutomu

    Pharmacology   Vol. 96 ( 5-6 ) page: 201-209   2015

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    DOI: 10.1159/000438993

  41. Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury. Reviewed

    TAKASHIMA Koji, MATSUSHIMA Miyoko, HASHIMOTO Katsunori, NOSE Haruka, SATO Mitsuo, HASHIMOTO Naozumi, HASEGAWA Yoshinori, KAWABE Tsutomu.

    Respir Res.   Vol. 15 ( 1 ) page: 150   2014.11

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    DOI: 10.1186/s12931-014-0150-x

  42. Catheter flow sensor with temperature compensation for tracheal intubation tube system Reviewed

    Mitsuhiro Shikida, Kazuhiro Yoshikawa, Takuya Matsuyama, Yudai Yamazaki, Miyoko Matsushima, Tsutomu Kawabe

    SENSORS AND ACTUATORS A-PHYSICAL   Vol. 215   page: 155 - 160   2014.8

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    A micro-electro-mechanical systems catheter flow sensor was integrated into the tracheal intubation tube system to prevent the insertion of the tube into the esophagus. A temperature sensing mechanism was integrated into the catheter flow sensor to compensate for the temperature change in air during flow-rate measurement, and the sensor was placed on the inside the slip joint by using an adapter produced using a molding process. The relationship between the sensor output and flow rate was evaluated, and closely matched sensor outputs for both the forward and backward flows were obtained. The tracheal tube in the modified system was inserted into the air passage of a rabbit, and the air flow passing through the tube was directly measured using the integrated catheter flow sensor in real time. By adding the temperature compensation mechanism, the volumes of the expired- and inspired-air almost matched. We believe that a doctor will easily be able to evaluate whether the tube is inserted into the bronchi or the esophagus when using the modified system. (C) 2013 Elsevier B.V. All rights reserved.

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  43. 呼吸器内科医を対象とした喘息治療ステップダウンの実態調査

    2. 武田直也、伊藤 理、指尾豊和、平松哲夫、木村智樹、大林浩幸、馬場研二、若原恵子、若山尚士、今泉和良、川部 勤、長谷川好規

    アレルギー・免疫   Vol. 21 ( 4 ) page: 106-114   2014.3

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  44. Postoperative muscle proteolysis affects systemic muscle weakness in patients undergoing cardiac surgery Reviewed

    Iida Y, Yamazaki T, Kawabe T, Usui A, Yamada S

    Int J Cardiol   Vol. 172 ( 3 ) page: 595-597   2014.1

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    DOI: 10.1016/j.ijcard.2014.01.062

  45. Development of Temperature-Compensated Catheter Flow Sensor for Measuring Reciprocating Air Flows in Bronchial Pathways Reviewed

    Matsuyama Takuya, Yamazaki Yudai, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

    IEEJ Transactions on Sensors and Micromachines   Vol. 134 ( 6 ) page: 126-131 - 131   2014

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    We introduced groove structures in between the flow- and temperature-sensors to avoid the heat flow to the temperature sensor from the heater used as the flow sensing. The grooves were produced by oxygen plasma etching, and thermal isolation effect by those was confirmed by an infrared thermography. The relationships between the flow rate and the flow sensor output with and without temperature compensation were evaluated. We finally confirmed that the variations of the flow sensor output by the change of the fluid temperature were successfully compensated by the temperature sensor.

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  46. Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells Reviewed

    Aoyama D, Hashimoto N, Sakamoto K, Kohnoh T, Kusunose M, Kimura M, Ogata R, Imaizumi K, Kawabe T, Hasegawa Y

    PLoS One   Vol. 8 ( 11 ) page: e81133   2013.11

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  47. [Immunoreaction and blood transfusion--chairmen's introductory remarks]. Reviewed

    Kawabe T, Matsushita T

    Rinsho byori. The Japanese journal of clinical pathology   Vol. 61 ( 5 ) page: 397 - 8   2013.5

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  48. An aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans Reviewed

    Hashimoto I, Imaizumi K, Hashimoto N, Furukawa H, Noda Y, Kawabe T, Honda T, Ogawa T, Matsuo M, Imai N, Ito S, Sato M, Kondo M, Shimokata K, Hasegawa Y

    Respirology   Vol. 18 ( 2 ) page: 340-347   2013.2

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    PMID: 23062110

  49. Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice. Reviewed

    Ohno T, Okamoto M, Hara T, Hashimoto N, Imaizumi K, Matsushima M, Nishimura M, Shimokata K, Hasegawa Y, Kawabe T.

    Immunogenetics   Vol. 65 ( 1 ) page: 17-24   2013.1

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    PubMed ID: 23081743

  50. Micromachined catheter flow sensor and its applications in breathing measurements in animal experiments. Reviewed

    Shikida M, Shikano T, Matsuyama T, Yamazaki Y, Matsushima M, Kawabe T.

    Microsyst Technol.   Vol. 20 ( 3 ) page: 505-513   2013.1

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    DOI: 10.1007/s00542-013-1855-3

  51. Feasibility Of New Device For Electrical Muscle Stimulation Immediately After Cardiovascular Surgery Reviewed

    Iwatsu K., Iida Y., Kono Y., Sampei H., Hagiwara Y., Ishida S., Iritani N., Kobayashi K., Kainuma M., Kawabe T., Usui A., Yamada S.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 187   2013

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  52. Respiratory Volume Estimation by a Stretchable Textile Sensor Reviewed

    Enokibori Yu, Ito Yoshu, Ikeda Koji, Suzuki Akihisa, Shimakami Yuuki, Kawabe Tsutomu, Mase Kenji

    SMART AND INTERACTIVE TEXTILES   Vol. 80   page: 136 - +   2013

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  53. THE RELATIONSHIP BETWEEN MUSCLE WEAKNESS AND POSTOPERATIVE CATABOLISM AFTER CORONARY ARTERY BYPASS GRAFT SURGERY Reviewed

    Iida Y., Iwatsu K., Kawabe T., Tsubouchi H., Usui A., Yamada S.

    INTENSIVE CARE MEDICINE   Vol. 38   page: S90 - S91   2012.10

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  54. Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells Reviewed

    Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.

    Mol Carcinog.   Vol. 51 ( 5 ) page: 400-410   2012.7

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    PMID: 21594904

  55. Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury Reviewed

    Sakamoto K, Hashimoto N, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, Kusunose M, Kimura M, Kawabe T, Taniguchi H, Hasegawa Y

    Am J Physiol Lung Cell Mol Physiol   Vol. 303 ( 1 ) page: L43-53   2012.7

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    PMID: 22561461

  56. Inspiratory capacity as a preoperative assessment of patients undergoing thoracic surgery Reviewed

    Matsuo M, Hashimoto N, Usami N, Imaizumi K, Wakai K, Kawabe T, Yokoi K, Hasegawa Y.

    Interact Cardiovasc Thorac Surg.   Vol. 14 ( 5 ) page: 560-564   2012.5

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  57. Observation of Fine Lung Structure by Ultrahigh-Resolution Optical Coherence Tomography Using 800, 1060, and 1300nm Supercontinua Reviewed

    Ishida S, Nishizawa N, Kitatsuji M, Ohshima H, Hasegawa Y, Matsushima M, Kawabe T.

    Jpn. J. Appl. Phys   Vol. 51   page: 047001   2012.3

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  58. Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells Reviewed

    Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, Kawabe T.

    Biochem Biophys Res Commun   Vol. 417 ( 1 ) page: 169-174   2012.1

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    PubMed ID: 22138401

  59. The usefulness of casein-specific IgE and IgG4 antibodies in cow's milk allergic children. Reviewed

    Ito K, Futamura M, Moverare R, Tanaka A, Kawabe T, Sakamoto T, Borres MP

    Clin Mol Allergy   Vol. 10 ( 1 ) page: 1-7   2012.1

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    PubMed ID: 22212305

  60. ミルクタンパク質全網羅ペプチドアレイを用いたIgG結合ペプチドの探索 Reviewed

    片山 真、杉田智哉、加藤竜司、大河内美奈、松島充代子、川部 勤、高瀬智和、吉田安子、川瀬三雄、本多裕之

    化学工学論文集   Vol. 37 ( 6 ) page: 546-550   2011.9

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  61. CD40/CD40 ligand interactions in immune responses and pulmonary immunity Reviewed

    Kawabe T, Matsushima M, Hashimoto N, Imaizumi K, Hasegawa Y.

    Nagoya J Med Sci   Vol. 73 ( 3-4 ) page: 69-78   2011.8

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  62. Attenuation of Transforming Growth Factor-β-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced Heme Oxygenase-1 Reviewed

    Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T.

    Am J Respir Cell Mol Biol   Vol. 44 ( 5 ) page: 614-620   2011.5

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  63. Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants Reviewed

    Yuki Takahashi, Koji Tamakoshi, Miyoko Matsushima, Tsutomu Kawabe

    EARLY HUMAN DEVELOPMENT   Vol. 87 ( 3 ) page: 151 - 157   2011.3

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    Background: There are few studies that compare the physiological and biological efficacies between different early skin-to-skin contacts (SSC) post birth.
    Aim: To investigate physiologically and biochemically how early SSC with different initiation and duration time influence the stress post birth for full-term infants.
    Study design: Non-experimental study.
    Subjects: Study I; Thirty-two infants who began SSC 5 min or less [birth SSC, mean initiation time (standard deviation): 1.6 (1.1) min] after birth and 36 infants who did so more than 5 min [very early SSC, 26.3 (5.0) min] in heart rate (HR) and oxygen saturation (SpO(2)) analysis. Study II; Eighteen infants who underwent SSC for 60 min or less [mean initiation time: 7.5 (12.2) min] and 61 infants who did so for more than 60 min [15.3 (12.5) min] in salivary cortisol analysis.
    Outcome measures: HR and SpO(2) measured for 30 min post birth. Salivary cortisol concentration measured at 1 min, 60 min, and 120 min post birth.
    Results: Birth SSC group reached HR stability of 120-160 bpm significantly faster than very early SSC group by Kaplan-Meier analysis (P=0.001 by log-rank test). As for SpO(2) stability of 92% and 96%, no significantly between-group difference was found. Salivary cortisol levels were significantly lower between 60 and 120 min after birth in SSC group, continuing for more than 60 min compared with SSC group for 60 min or less after adjustment for salivary cortisol level at 1 min besides the infant stress factors (P=0.046).
    Conclusions: Earlier SSC beginning within 5 min post birth and longer SSC continuing for more than 60 min within 120 min post birth are beneficial for stability of cardiopulmonary dynamics and the reduction of infant stress during the early period post birth. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

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  64. Ex-vivo ultra-high-resolution optical coherence tomography imaging of fine lung structure by use of a high-power Gaussian-like supercontinuum at 0.8-um wavelength. Reviewed

    Nishizawa N., Ishida S., Ohta T., Itoh K., Kitatsuji M., Ohshima H., Hasegawa Y., Matsushima M., Kawabe T.

    ENDOSCOPIC MICROSCOPY VI   Vol. 7893   2011

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  65. The Role Of Interleukin-17/Th17 In Human Interstitial Pneumonia Reviewed

    Ogawa T., Imaizumi K., Hashimoto N., Hashimoto I., Imai N., Tomita Y., Kounou T., Sakamoto K., Aoyama D., Kusunose M., Ito S., Sato M., Kondo M., Kawabe T., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 183   2011

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  66. Characteristics of an optimized catheter-type thermal flow sensor for measuring reciprocating airflows in bronchial pathways Reviewed

    M. Shikida, T. Yokota, T. Kawabe, T. Funaki, M. Matsushima, S. Iwai, N. Matsunaga, K. Sato

    JOURNAL OF MICROMECHANICS AND MICROENGINEERING   Vol. 20 ( 12 ) page: 1-11   2010.12

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    We optimized a catheter-type thermal flow sensor to measure the reciprocating airflows in bronchial pathways. The electrical wiring in the outer tube was extracted to keep the symmetry of the temperature distribution on the heaters. First, a flexible sensor was fabricated on polyimide film with photolithography, and then the enameled wires were bonded to the contact pads on the film with anisotropic conductive film. The film sensor was finally assembled with a catheter configuration that had a diameter of 1.8 mm by applying a heat shrinkable tube. We experimentally confirmed that the sensor outputs under both forward and reverse flow conditions had the same output characteristics when a design with symmetrical heating elements was applied. The sensor outputs we obtained at a reciprocating flow frequency ranging from 1 to 3 Hz almost coincided, and they also fit that obtained under unidirectional airflow conditions. Finally, the aspirated-and inspired-air characteristics in the air passages of small laboratory animals (rats and mice) were measured. Due to our development of a flexible method of electrical wiring, we could try a new approach to intubation measurements in which the sensor was inserted into the air passage from the mouth with a fiberscope, and we confirmed that the sensor we developed was able to directly measure the breathing characteristics in air passages. Implanted measurements were also attempted in this study.

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  67. Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues. Reviewed

    Hirayama T, Kawabe T, Matsushima M, Nishimura Y, Kobe Y, Ota Y, Baba K, Takagi K.

    Peptides   Vol. 31 ( 11 ) page: 2109-13   2010.11

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  68. Endothelial-Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis Reviewed

    Naozumi Hashimoto, Sem H. Phan, Kazuyoshi Imaizumi, Masaki Matsuo, Harunori Nakashima, Tsutomu Kawabe, Kaoru Shimokata, Yoshinori Hasegawa

    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY   Vol. 43 ( 2 ) page: 161 - 172   2010.8

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    The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, in which fibroblasts are thought to be involved in the tissue remodeling, matrix deposition, and cross-talk with alveolar epithelium. Recent evidence indicates that some fibroblasts in fibrosis may be derived from bone marrow progenitors as well as from epithelial cells through epithelial-mesenchymal transition. To evaluate whether endothelial cells could represent an additional source for fibroblasts, bleomycin-induced lung fibrosis was established in Tie2-Cre/CAG-CAT-LacZ double-transgenic mice, in which LacZ was stably expressed in pan-endothelial cells. Combined X-gal staining and immunocytochemical staining for type I collagen and alpha-smooth muscle actin revealed the presence of X-gal-positive cells in lung fibroblast cultures from bleomycin-treated mice. To explore the underlying mechanisms, by which loss of endothelial-specific markers and gain of mesenchymal phenotypes could be involved in microvascular endothelial cells, the effects of activated Ras and TGF-beta on the microvascular endothelial cell line MS1 were analyzed. Combined treatment with activated Ras and TGF-beta caused a significant loss of endothelial-specific markers, while inducing de nova mesenchymal phenotypes. The altered expression of these markers in MS1 cells with activated Ras persisted after withdrawal of TGF-beta in vitro and in vivo. These findings are the first to show that lung capillary endothelial cells could give rise to significant numbers of fibroblasts through an endothelial-mesenchymal transition in bleomycin-induced lung fibrosis model.

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  69. Differential Th1/Th2 chemokine expression in interstitial pneumonia. Reviewed

    Honda T, Imaizumi K, Yokoi T, Hashimoto N, Hashimoto I, Kawabe T, Matsuo M, Iwano S, Shimokata K, Hasegawa Y.

    Am J Med Sci   Vol. 339 ( 1 ) page: 41-8   2010.1

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  70. Differential T(H)1/T(H)2 Chemokine Expression in Interstitial Pneumonia Reviewed

    Honda Toyohiro, Imaizumi Kazuyoshi, Yokoi Toyoharu, Hashimoto Naozumi, Hashimoto Izumi, Kawabe Tsutomu, Matsuo Masaki, Iwano Shingo, Shimokata Kaoru, Hasegawa Yoshinori

    AMERICAN JOURNAL OF THE MEDICAL SCIENCES   Vol. 339 ( 1 ) page: 41 - 48   2010.1

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  71. Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells. Reviewed

    Matsushima M, Takagi K, Ogawa M, Hirose E, Ota Y, Abe F, Baba K, Hasegawa T, Hasegawa Y, Kawabe T.

    Inflammation Research   Vol. 58 ( 10 ) page: 705-715   2009.10

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  72. A catheter-type flow sensor for measurement of aspirated- and inspired-air characteristics in the bronchial region. Reviewed

    Shikida M, Naito J, Yokota T, Kawabe T, Hayashi Y and K Sato.

    J Micromech Microeng   Vol. 19 ( 10 ) page: 1-9   2009.10

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  73. Peptide array-based analysis of the specific IgE and IgG4 in cow's milk allergens and its use in allergy evaluation. Reviewed

    Matsumoto N, Okochi M, Matsushima M, Kato R, Takase T, Yoshida Y, Kawase M, Isobe K, Kawabe T, Honda H.

    Peptides   Vol. 30 ( 10 ) page: 1840-1847   2009.10

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  74. Erythromycin-induced CXCR4 expression on microvascular endothelial cells. Reviewed

    Takagi Y, Hashimoto N, Phan SH, Imaizumi K, Matsuo M, Nakashima H, Hashimoto I, Hayashi Y, Kawabe T, Shimokata K, Hasegawa Y.

    Am J Physiol (Lung Cell Mol Physiol)   Vol. 297 ( 3 ) page: L420-431   2009.9

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  75. An influence of Interferon-gamma gene polymorphisms on treatment response to tuberculosis in Japanese population. Reviewed

    Shibasaki M, Yagi T, Yatsuya H, Okamoto M, Nishikawa M, Baba H, Hashimoto N, Senda K, Kawabe T, Nakashima K, Imaizumi K, Shimokata K, Hasegawa Y.

    Journal of Infection   Vol. 58 ( 6 ) page: 467-469   2009.6

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  76. Up-regulation of surfactant protein production in a mouse model of secondary pulmonary alveolar proteinosis. Reviewed

    Shibasaki M, Hashimoto K, Okamoto M, Hayashi Y, Imaizumi K, Hashimoto N, Ozaki N, Yokoi T, Takagi K, Hasegawa Y, Shimokata K, Kawabe T.

    Am J Respir Cell Mol Biol   Vol. 40 ( 5 ) page: 536-542   2009.5

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  77. Involvement of heme oxygenase-1 in kaempferol-induced anti-allergic actions in RBL-2H3 cells. Reviewed

    Hirose E, Matsushima M, Takagi K, Ota Y, Ishigami K, Hirayama T, Hayashi Y, Nakamura T, Hashimoto N, Imaizumi K, Baba K, Hasegawa Y, Kawabe T.

    Inflammation   Vol. 32 ( 2 ) page: 99-108   2009.4

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  78. Inhibition of Degranulation by Myricetin-induced Heme Oxygenase-1 in Mast Cells Reviewed

    Ota Y, Matsushima M, Ogawa M, Hirose E, Hirayama T, Yuasa E, Yabuta K, Baba K, Hasegawa Y, Takagi K, Kawabe T.

    Occupational and Environmental Allergy   Vol. 16 ( 2 ) page: 61-73   2009.4

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  79. Development of peptide arrays for detection of IgE-binding epitopes in cow's milk allergens. Reviewed

    Matsumoto N, Okochi M, Matsushima M, Ogawa A, Takase T, Yoshida Y, Kawase M, Isobe K, Kawabe T, Honda H.

    J Biosci Bioeng   Vol. 107 ( 3 ) page: 324-30   2009.3

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  80. Milk Allergen-Specific IgE And IgG4 Antibodies In Patients With Milk Allergy Reviewed

    Ito K., Futamura M., Hirayama M., Otsuji K., Kawabe T., Sakamoto T., Tanaka A.

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   Vol. 123 ( 2 ) page: S181 - S181   2009.2

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  81. Cytoprotective Effect of Geranylgeranylacetone in Bleomycin-Induced Lung Injury/Fibrosis. Reviewed

    Hashimoto N., Fujibayashi T., Nakashima H., Matsuo M., Imaizumi K., Kawabe T., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 179   2009

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  82. Involvement of Transcription Factor Twist into Phenotype Change in Lung Cancer Cells through Epithelial-Mesenchymal Transition. Reviewed

    Nakashima H., Hashimoto N., Imaizumi K., Matsuo M., Hashimoto I., Nakamura T., Hayashi Y., Kawabe T., Hasegawa Y.

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   Vol. 179   2009

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  83. Th1/Th2 chemokines produced by lung fibroblasts and their evaluation in interstitial lung disease. Reviewed

    Sumida A, Hasegawa Y, Okamoto M, Hashimoto N, Imaizumi K, Yatsuya H, Yokoi T, Takagi K, Shimokata K, and Kawabe T.

    Arch Med Res   Vol. 39 ( 5 ) page: 503-510   2008.7

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  84. Th1/Th2 immune response in lung fibroblasts in interstitial lung disease Reviewed

    Sumida Atsushi, Hasegawa Yoshinori, Okamoto Masakazu, Hashimoto Naozumi, Imaizumia Kazuyoshi, Yatsuya Hiroshi, Yokoi Toyoharu, Takagi Kenzo, Shimokata Kaoru, Kawabe Tsutomu

    ARCHIVES OF MEDICAL RESEARCH   Vol. 39 ( 5 ) page: 503 - 510   2008.7

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    Background: Inflammatory response in pulmonary fibrosis closely resembles a T-helper (Th) 2 immune response. For recruitment to an inflammatory lesion, the majority of Th1 cells express CXC chemokine receptor 3, recognizing monokine induced by interferon-gamma (Mig), interferon γ-inducible protein of 10 kD (IP-10), and interferon-inducible T-cell α chemoattractant (I-TAC). Th2 cells express CC chemokine receptor 4, recognizing thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC). We investigated the Th1/Th2 chemokine production patterns by lung fibroblasts and their evaluation in bronchoalveolar lavage (BAL) fluid of interstitial lung disease. Methods: The production pattern of Th1/Th2 chemokines by lung fibroblasts was examined in ELISA and quantitative reverse transcriptase polymerase chain reactions. Th1/Th2 chemokine levels in BAL fluid of idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) were examined to evaluate the clinical relevance of Th1/Th2 chemokines. Results: The lung fibroblasts were polarized to produce Th1-type chemokines by the pro-inflammatory cytokine, tumor necrosis factor (TNF)-α and the anti-fibrotic cytokine, interferon (IFN)-γ. However, the induction patterns of chemokines by these two cytokines were different, i.e., involving predominant induction of IP-10 and I-TAC by TNF-α and induction of Mig by IFN-γ. Although Mig, IP-10, and I-TAC were produced within the BAL fluid of patients, TARC and MDC were at significantly low levels. Conclusions: Our results suggest that lung fibroblasts tend to induce a Th1-type immune response under normal conditions, and that a Th2-type immune response does not play a significant role in smoldering inflammation around the established lesions in IPF and NSIP. © 2008 IMSS.

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  85. Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells. Reviewed

    Hara T, Yamakura F, Takikawa O, Hiramatsu R, Kawabe T, Isobe KI, Nagase F.

    J Immunol Methods   Vol. 332 ( 1-2 ) page: 162-169   2008.3

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  86. High-affinity uptake of kynurenine and nitric oxide-mediated inhibition of indoleamine 2,3-dioxygenase in bone marrow-derived myeloid dendritic cells. Reviewed

    Hara T, Ogasawara N, Akimoto H, Takikawa O, Hiramatsu R, Kawabe T, Isobe K, Nagase F.

    Immunol Letters   Vol. 116 ( 1 ) page: 95-102   2008.2

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  87. Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. Reviewed

    Hiramatsu R, Hara T, Akimoto H, Takikawa O, Kawabe T, Isobe K, Nagase F.

    J Cell Biochem   Vol. 103 ( 1 ) page: 42-53   2008.1

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  88. Xenin and xenopsin induce histamine release from rat peritoneal mast cells. Reviewed

    Matsushima M, Kitaichi K, Kawabe T, Suzuki R, Baba K, Hasegawa T, Takagi K

      Vol. 14 ( 2 ) page: 60-67   2007.9

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  89. Macrophage-derived chemokine in malignant and tuberculous pleurisy Reviewed

    Okamoto M, Imaizumi K, Hasegawa Y, Hashimoto N, Sumida A, Shibazaki M, Takagi K, Shimokata K, Kawabe T,

    Respirology   Vol. 12   page: 581–584   2007.7

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  90. Macrophage-derived chemokine in malignant and tuberculous pleural effusions Reviewed

    Okamoto Masakazu, Imaizumi Kazuyoshi, Hasegawa Yoshinori, Hashimoto Naozumi, Sumida Atsushi, Shibazaki Masataka, Takagi Kenzo, Shimokata Kaoru, Kawabe Tsutomu

    RESPIROLOGY   Vol. 12 ( 4 ) page: 581 - 584   2007.7

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    Background and objectives: Macrophage-derived chemokine (MDC/CCL22) is recognized as a T-helper (Th) 2-type chemokine. Both malignant and tuberculous pleural effusions are typically lymphocytic pleural effusions. Tuberculous pleural effusions have a more polarized Th1 reaction than malignant effusions, which are predominantly Th2 in nature. The aim of this study was to compare the levels of MDC in malignant pleural effusions with those in tuberculous pleural effusions to help delineate the role of MDC in Th2 versus Th1 effusions. Methods: Forty-three patients with pleural effusions (32 malignant, 11 tuberculous) were studied. The concentration of MDC in the pleural effusion was measured by ELISA. Results: The median concentration of MDC was lower in malignant pleural effusions than in tuberculous pleural effusions (P < 0.005). Conclusions: MDC has been reported to both promote and suppress antitumour immunity. The low concentration of MDC in malignant effusions is likely to minimise its antitumour activity but the precise role of MDC in malignant and tuberculous effusions needs to be investigated further. © 2007 The Authors.

    DOI: 10.1111/j.1440-1843.2007.01059.x

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  91. Expression of macrophage-derived chemokine (MDC)/CCL22 in human lung cancer. Reviewed

    Nakanishi T, Imaizumi K, Hasegawa Y, Kawabe T, Hashimoto N, Okamoto M, Shimokata K,

    Cancer Immunol Immunother   Vol. 55 ( 11 ) page: 1320-1329   2006.11

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  92. Successful re-treatment with gefitinib for carcinomatous meningitis as disease recurrence of non-small-cell lung cancer Reviewed

    Hashimoto N, Imaizumi K, Honda T, Kawabe T, Nagasaka T, Shimokata K, T, Hasegawa Y,

    Lung cancer   Vol. 53 ( 3 ) page: 387-390   2006.9

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  93. Pulmonary infectious complications associated with anti-TNF&#61537; therapy (infliximab) for rheumatoid arthritis. Reviewed

    Imaizumi K, Sugishita M, Usui M, Kawabe T, Hashimoto N, Hasegawa Y.

    Intern Med   Vol. 45 ( 10 ) page: 685-688   2006.6

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  94. 総説:マウス喘息モデルを用いた疾患感受性遺伝子の検索 Invited Reviewed

    川部 勤

    日本職業・環境アレルギー学会誌   Vol. 13 ( 2 ) page: 1-10   2006.5

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    我々の研究室ではリコンビナント近交系マウスを用いて気管支喘息感受性遺伝子の同定を試みたので、マウスの系の解説から現在までの知見、さらに解析方法について総説した。

  95. Pulmonary infectious complications associated with anti-TNF alpha therapy (infliximab) for rheumatoid arthritis Reviewed

    Imaizumi Kazuyoshi, Sugishita Mihoko, Usui Miho, Kawabe Tsutomu, Hashimoto Naozumi, Hasegawa Yoshinori

    INTERNAL MEDICINE   Vol. 45 ( 10 ) page: 685 - 688   2006

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    Two patients with rheumatoid arthritis (RA) that developed serious infectious complications following anti-TNFα therapy (infliximab) are reported. Patient 1 developed tuberculosis with high fever, refractory diarrhea and mediastinal lymphadenopathy. Trans-bronchial needle biopsy was useful to confirm the diagnosis. Patient 2 showed sudden onset of dyspnea with diffuse bilateral lung infiltration caused by pneumocystis jiroveci pneumonia and the diagnosis was confirmed by broncho-alveolar lavage. Physicians should be alerted to infectious complications with atypical presentation and rapid progression in infliximab-treated patients. Invasive diagnostic procedures including fiber-optic bronchoscopy may be necessary early in the course for such cases. © 2006 The Japanese Society of Internal Medicine.

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  96. Th1/Th2 Balance in Malignant Pleural Effusions Compared to Tuberculous Pleural Effusions Reviewed

    Chest   Vol. 128   page: p4030-4035   2005.12

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  97. Interstitial lung disease associated with gefitinib. Reviewed

    Kataoka K, Taniguchi H, Hasegawa Y, Kondoh Y, Kimura T, Nishiyama O, Imaizumi K, Kawabe T, Kume H, Shimokata K,

    Respiratory Medicine   Vol. 100 ( 4 ) page: 698-704   2005.4

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  98. Evaluation of interferon-gamma, interferon-gamma-inducing cytokines, and interferon-gamma-inducible chemokines in tuberculous pleural effusions Reviewed

    Okamoto M, Kawabe T, Iwasaki Y, Hara T, Hashimoto N, Imaizumi K, Hasegawa Y, Shimokata K

    J Lab Clin Med   Vol. 145 ( 2 ) page: 88-93   2005.2

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  99. Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells. Reviewed

    Ito G, Uchiyama M, Kondo M, Mori S, Usami N, Maeda O, Kawabe T, Hasegawa Y, Shimokata K, Sekido Y

    Cancer research   Vol. 64 ( 11 ) page: 3838 - 43   2004.6

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    Krüppel-like factor 6 (KLF6) is a ubiquitously expressed zinc finger transcriptional factor, which has been suggested to be a candidate tumor suppressor gene in prostate cancer and astrocytic glioma. Because KLF6 is located at chromosome 10p15, where non-small cell lung cancers (NSCLCs) also exhibit frequent allelic loss, we hypothesized that the inactivation of KLF6 is also involved in the development of NSCLC. To determine this, we performed mutational analysis for 105 NSCLCs, including 9 cell lines and 96 primary tumors, and Northern blot analysis for 74 NSCLCs, including the 9 cell lines and 65 primary tumors. Although somatic mutations were not detected in the coding sequence of KLF6, expression of KLF6 mRNA was down-regulated in the 9 cell lines and in 55 (85%) of the 65 primary tumors compared with normal lung tissue. Treatment of two cell lines expressing KLF6 at low levels with 5-azacytidine did not induce KLF6 expression, suggesting that KLF6 down-regulation is not due to promoter hypermethylation. We also performed loss of heterozygosity (LOH) analysis using the laser capture microdissection technique, and found that 21 of 62 (34%) informative samples had LOH in the KLF6 gene locus. Comparing the LOH status with mRNA expression of KLF6, we found that 14 of the 14 (100%) samples with LOH showed KLF6 down-regulation, and that even 23 of 31 (74%) samples without LOH also showed this down-regulation. We also studied the expression of the WAF1 gene, a possible downstream gene of KLF6, and detected simultaneous down-regulation of WAF1 and KLF6 mRNA in 6 of 9 (67%) cell lines and 48 of the 55 (87%) primary tumors, although there was not a significant association between loss of KLF6 and WAF1 expression. Furthermore, colony formation assay of two NSCLC cell lines (NCI-H1299 and NCI-H2009) induced a markedly reduced colony formation by KLF6 transfection, and Annexin V staining and terminal deoxynucleotidyl transferase-mediated nick end labeling assays revealed that KLF6 induced apoptosis. Our present studies demonstrated that KLF6 is frequently down-regulated in NSCLC and suppresses tumor growth via induction of apoptosis in NSCLC, which may suggest that KLF6 is a tumor suppressor for NSCLC.

    DOI: 10.1158/0008-5472.CAN-04-0185

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  100. CD40 plays a crucial role in lipopolysaccharide-induced acute lung injury Reviewed

    Hashimoto N, Kawabe T, Imaizumi K, Hara T, Okamoto M, Kojima K, Shimokata K, Hasegawa Y

    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY   Vol. 30 ( 6 ) page: 808 - 815   2004.6

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    DOI: 10.1165/rcmb.2003-0197OC

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  101. CD40 plays a crucial role in LPS-induced acute lung injury Reviewed

    Kawabe T, Hashimoto N, Imaizumi K, Hara T, Okamoto M, Kojima K, Shimokata K, Hasegawa Y

    Am J Respir Cell Mol Biol   Vol. 30 ( 6 ) page: 808-815   2004.4

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  102. Kruppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells Reviewed

    Ito G, Uchiyama M, Kondo M, Mori S, Usami N, Maeda O, Kawabe T, Hasegawa Y, Shimokata K, Sekido Y

    Cancer Res   Vol. 64 ( 11 ) page: 3838-3843   2004.4

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  103. DR1-like element in human topoisomerase II&#61537; gene involved in enhancement of etoposide-induced apoptosis by PPAR gamma ligand Reviewed

    Kanbe E, Abe A, Towatari M, Kawabe T, Emi N, Saito H

    Exp Hematol   Vol. 31 ( 4 ) page: 300–308   2003.4

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  104. DR1-like element in human topoisomerase II alpha gene involved in enhancement of etoposide-induced apoptosis by PPAR gamma ligand Reviewed

    Kanbe E, Abe A, Towatari M, Kawabe T, Saito H, Emi N

    EXPERIMENTAL HEMATOLOGY   Vol. 31 ( 4 ) page: 300 - 308   2003.4

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    Objective. The nuclear peroxisome proliferator-activated receptor γ (PPARγ) ligands may enhance the etoposide-induced apoptosis by modulating the topoisomerase (Topo) IIα expression through binding to direct repeat 1 (DR1)-like element. Methods. To investigate the effect of etoposide-induced apoptosis by PPARγ ligands, leukemia cell lines were treated with troglitazone and 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) in the presence of etoposide and studied about various biological responses. Results. We found the enhancement of etoposide-induced apoptosis by PPARγ ligands in several leukemia cell lines, which was dependent on the expression of PPARγ and specific for TopoIIα inhibitor. We also observed the increased expression of TopoIIα protein by 15d-PGJ2 in Jurkat and HUVEC cells, which might lead to the increased sensitivity to etoposide. Furthermore, we demonstrated that 15d-PGJ2 enhanced the promoter activity of human TopoIIα promoter construct with a DR1-like site by sevenfold when expressed with PPARγ and RXRα. The mutation of DR1-like site decreased the promoter activity, although the direct binding between DR1-like site and PPARγ/RXRα heterodimer was not demonstrated. Conclusions. We conclude that the induction of TopoIIα expression by PPARγ ligands via DR1-like site is an important mechanism for the enhancement of etoposide-induced apoptosis and a DR1-like site in TopoIIα promoter is involved in transcriptional regulation dependent on PPARγ ligands and PPARγ/RXRα heterodimer. © 2003 International Society for Experimental Hematology. Published by Elsevier Science Inc.

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  105. Perfusion and ventilation isotope lung scans in constrictive bronchiolitis obliterans. A series of three cases Reviewed

    Hasegawa Y, Imaizumi K, Sekido Y, Iinuma Y, Kawabe T, Hashimoto N, Shimokata K

    Respiration   Vol. 69 ( 6 ) page: 550-555   2002.4

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  106. Critical involvement of CD40 in protection against herpes simplex virus infection in a murine model of genital herpes Reviewed

    Inagaki-Ohara K, Kawabe T, Hasegawa Y, Hashimoto N, Nishiyama Y.

    Arch Virol   Vol. 147 ( 1 ) page: 187-194   2002.4

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  107. Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-γ gene into lung cancer Reviewed

    Noguchi M., Imaizumi K., Kawabe T., Wakayama H., Horio Y., Sekido Y., Hara T., Hashimoto N., Takahashi M., Shimokata K., Hasegawa Y.

    Cancer Gene Therapy   Vol. 8 ( 6 ) page: 421 - 429   2001.8

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    CD40-CD40 ligand (CD40L) interaction is an important costimulatory signaling pathway in the crosstalk between T cells and antigen-presenting cells. This receptor-ligand system is known to be essential in eliciting strong cellular immunity. Here we demonstrate that murine lung cancer cells (3LLSA) transduced with the CD40L gene (3LLSA-CD40L) were rejected in syngeneic C57BL/6 mice, but grew in CD40-deficient mice to the same extent as control tumor cells. Immunohistochemical study showed that inflammatory cells, including CD4+, CD8+ T cells and NK cells, infiltrated into the inoculated 3LLSA-CD40L tumor tissue. Inoculation of 3LLSA-CD40L cells into mice resulted in the induction of 3LLSA-specific cytotoxic T-cell immunity, and the growth of parental 3LLSA tumors was inhibited when 3LLSA cells were inoculated into C57BL/6 mice mixed with 3LLSA-CD40L cells or when they were rechallenged 4 weeks after 3LLSA-CD40L cells were rejected. Furthermore, co-inoculation of interferon (IFN)-γ-transduced cells (3LLSA-IFNγ) with 3LLSA-CD40L cells enhanced the antitumor immunity efficiently in vivo. These results indicate that the in vivo priming with CD40L- and IFN-γ gene-transduced lung cancer cells is a promising strategy for inducing antitumor immunity in the treatment of lung cancer.

    DOI: 10.1038/sj.cgt.7700320

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  108. Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-gamma gene into lung cancer Reviewed

    Imaizumi K, Kawabe T, Kikutani H, Yagita H, Shimokata K, Hasegawa Y

    Cancer Gene Ther   Vol. 8 ( 6 ) page: 421-429   2001.4

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  109. Effect of erythromycin on matrix metalloproteinase-9 and cell migration Reviewed

    Hashimoto N, Kawabe T, Hara T, Imaizumi K, Wakayama H, Saito H, Shimokata K, Hasegawa Y.

    J Lab Clin Med   Vol. 137 ( 3 ) page: 176-183   2001.4

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  110. Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression Reviewed

    Kobayashi K.I.

    Cancer Research   Vol. 60 ( 14 ) page: 3978 - 3984   2000.7

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  111. Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRγ-deficient mice Reviewed

    Wakayama H., Hasegawa Y., Kawabe T., Hara T., Matsuo S., Mizuno M., Takai T., Kikutani H., Shimokata K.

    European Journal of Immunology   Vol. 30 ( 4 ) page: 1182 - 1190   2000.5

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    Several recent studies have demonstrated the central role of Fc receptors (FcR) rather than the complement system in triggering hypersensitivity reactions. We investigated the role of FcR for IgG (FcγR) using a murine model of accelerated anti-glomerular basement membrane (GBM) antibody-mediated glomerulonephritis as a representative of type II hypersensitivity diseases. Intravenous injection of rabbit anti-GBM antibody after preimmunization with normal rabbit IgG induced proteinuria and azotemia in wild-type C57BL/6 and CD40(+/-) mice but not in FcR γ chain (FcRγ)(-/-) mice or CD40(-/-) mice. Light microscopic findings revealed marked tissue damage in the glomeruli of wild-type C57BL/6 and CD40(+/-) mice. However, no tissue damage except polymorphonuclear cell infiltration was observed in the glomeruli of FcRγ(-/-) mice. The glomeruli of CD40(-/-) mice were almost normal. Immunohistochemistry revealed the binding of rabbit IgG to the GBM in all mice injected with anti-GBM antibody. However, depositions of mouse IgG and complement to the glomeruli were not observed in CD40(-/-) mice, and deposition of fibrin was not observed in FcRγ(-/-) or CD40(-/-) mice. These findings suggest that FcγR may initiate anti-GBM antibody-mediated renal disease. We conclude that FcγR rather than the complement system is critically involved in the development of type II hypersensitivity diseases.

    DOI: 10.1002/(SICI)1521-4141(200004)30:4<1182::AID-IMMU1182>3.0.CO;2-H

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  112. Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcR gamma-deficient mice Reviewed

    Wakayama H, Hasegawa Y, Kawabe T, Hara T, Matsuo S, Mizuno M, Takai T, Kikutani H, Shimokata K

    Eur J Immunol   Vol. 30 ( 4 ) page: 1182-1190   2000.4

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  113. Enhancement of tumoricidal activity of alveolar macrophages via CD40- CD40 ligand interaction Reviewed

    Imaizumi K., Kawabe T., Ichiyama S., Kikutani H., Yagita H., Shimokata K., Hasegawa Y.

    American Journal of Physiology - Lung Cellular and Molecular Physiology   Vol. 277 ( 1 21-1 )   1999.7

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    CD40-CD40 ligand (CD40L) interaction was originally defined as important molecules for the development of humoral immunity. Thereafter, some investigations have focused on its essential roles for the induction of cell- mediated immunity in host defenses. Here we investigated the antitumor activity of murine alveolar macrophages through CD40-CD40L interaction. The CD40L gene was transfected into murine lung cancer cells (3LLSA), and CD40L- expressing clones (3LLSA-CD40L) were established. Stimulation of CD40 molecules on the surface of alveolar macrophages with 3LLSA-CD40L cells induced the production of nitric oxide, tumor necrosis factor-α, and interleukin-12 and the tumoricidal activity of alveolar macrophages in the presence of interferon-γ, which increased the surface expression of CD40 molecules on alveolar macrophages. These findings were not observed when alveolar macrophages were obtained from CD40-deficient mice. On the other hand, interleukin-6 production by alveolar macrophages did not depend on CD40-CD40L interaction. We also established a murine melanoma cell line expressing CD40L (B16 4A5-CD40L) that could induce tumoricidal activity of alveolar macrophages. Furthermore, when spleen cells were cocultivated with 3LLSA-CD40L cells, specific cytotoxic T lymphocytes for wild-type 3LLSA cells could be induced. These results suggest that CD40L gene transfer into tumor cells may induce antitumor immunity in a tumor-bearing host and may offer a new strategy for cancer gene therapy.

    DOI: 10.1152/ajplung.1999.277.1.l49

    Scopus

  114. 気管内挿管後高度の気管狭窄をきたした1例 Reviewed

    佐藤光夫,川部勤,堀尾芳嗣,長谷川好規,下方 薫

    気管支学   Vol. 21 ( 6 ) page: 427-428   1999.6

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  115. SHIP recruitment attenuates FcγRIIB-induced B cell apoptosis Reviewed

    Pearse R., Kawabe T., Bolland S., Guinamard R., Kurosaki T., Ravetch J.

    Immunity   Vol. 10 ( 6 ) page: 753 - 760   1999.6

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    FcγRIIB is an inhibitory receptor that terminates activation signals initiated by antigen cross-linking of the BCR through the recruitment of SHIP. FcγRIIB can also signal independently of BCR coligation to directly mediate an apoptotic response, requiring only an intact transmembrane domain. Failure to recruit SHIP, either by deletion of SHIP or mutation of FcγRIIB, results in enhanced FcγRIIB-triggered apoptosis. Thus, in the germinal center, where ICs are retained by FDCs, FcγRIIB may be an active determinant in the negative selection of B cells whose BCRs have reduced affinity for antigen as a result of somatic hypermutation. Selection of B cells may represent the sum of opposing signals generated by the interaction of ICs with the BCR and FcγRIIB through pathways modulated by SHIP.

    DOI: 10.1016/S1074-7613(00)80074-6

    Scopus

  116. Enhancement of tumoricidal activity of alveolar macrophage via CD40/CD40-ligand interaction Reviewed

    Imaizumi K, Kawabe T, Ichiyama S, Kikutani H, Yagita H, Shimokata K, Hasegawa Y.

    Am J Physiol (Lung Cell Mol Physiol)   Vol. 277   page: L49-L57   1999.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  117. Effect of Gene Transfer of Tumor Necrosis Factor Receptors into Human Lung Carcinoma Cell Line Reviewed

    OHARA Hisao, HASEGAWA Yoshinori, KAWABE Tsutomu, ICHIYAMA Satoshi, HARA Toru, SHIMONO Yohei, SAITO Hidehiko, SHIMOKATA Kaoru

    Japanese journal of cancer research : gann   Vol. 89 ( 5 ) page: 589 - 595   1998.5

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  118. Bystander tumoricidal effect and gap junctional communication in lung cancer cell lines Reviewed

    Imaizumi K, Hasegawa Y, Kawabe T, Emi N, Saito H, Naruse K, Shimokata K

    Am J Respir Cell Mol Biol   Vol. 18 ( 2 ) page: 205-212   1998.4

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  119. IgG-mediated anaphylaxis via Fcγ receptor in CD40-deficient mice Reviewed

    Wakayana H, Hasegawa Y, Kawabe T, Saito H, Kikutani H, Shimokata K

    Clin Exp Immunol   Vol. 114 ( 2 ) page: 154-160   1998.4

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  120. Effect of gene transfer of tumor necrosis factor receptors into human lung carcinoma cell line Reviewed

    Ohara H, Hasegawa Y, Kawabe T, Ichiyama S, Hara T, Shimono Y, Saito H, Shimokata K

    Jpn J Cancer Res   Vol. 89 ( 5 ) page: 589-595   1998.4

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  121. Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization Reviewed

    Ono T.

    Cytogenetic and Genome Research   Vol. 79 ( 1-2 ) page: 101 - 102   1997.1

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    Publishing type:Research paper (scientific journal)   Publisher:Cytogenetic and Genome Research  

    DOI: 10.1159/000134692

    Scopus

  122. The roles of CD40 and CD23 in IgE regulation Reviewed

    Yasui T, Fujiwara H, Kamanaka M, Kawabe T, Yoshida K, Kishimoto T, Kikutani H

    Adv Exp Med Biol   Vol. 409   page: 349-354   1996.4

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  123. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity Reviewed

    Kamanaka M, Yu P, Yasui T, Yoshida K, Kawabe T, Horii T, Kishimoto T, Kikutani H

    IMMUNITY   Vol. 4 ( 3 ) page: 275 - 281   1996.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Web of Science

  124. THE IMMUNE-RESPONSES IN CD40-DEFICIENT MICE - IMPAIRED IMMUNOGLOBULIN CLASS SWITCHING AND GERMINAL CENTER FORMATION Reviewed

    KAWABE T, NAKA T, YOSHIDA K, TANAKA T, FUJIWARA H, SUEMATSU S, YOSHIDA N, KISHIMOTO T, KIKUTANI H

    IMMUNITY   Vol. 1 ( 3 ) page: 167 - 178   1994.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Web of Science

  125. Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors Reviewed

    Hasegawa Y, Emi N, Shimokata K, Abe A, Kawabe T, Hasegawa T, Kirioka T, Saito H

    Am J Respir Cell Mol Biol   Vol. 8 ( 6 ) page: 655-661   1993.4

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  126. *Immunosuppressive activity induced by nitric oxide in culture supernatant of activated rat alveolar macrophages Reviewed

    Kawabe T, Isobe K, Hasegawa Y, Nakashima I, Shimokata K

    Immunology   Vol. 76 ( 1 ) page: 72-78   1992.4

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  127. D-52 レトロウイルスベクターを用いたチミジン・キナーゼ遺伝子導入による肺癌遺伝子治療へのアプローチ Reviewed

    長谷川 好規, 恵美 宣彦, 安部 明弘, 川部 勤, 野村 史郎, 渡辺 篤, 坂 英雄, 下方 薫

    肺癌   Vol. 31 ( 5 ) page: 695 - 695   1991.10

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    Publishing type:Research paper (scientific journal)   Publisher:日本肺癌学会  

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Books 29

  1. 肺酸素中毒症 呼吸器症候群(第3版)–その他の呼吸器疾患を含めて- I II 呼吸不全、換気異常 I.呼吸不全 別冊日本臨牀 新領域別症候群シリーズ No.17

    川部 勤( Role: Sole author)

    日本臨牀社  2021.8 

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    Total pages:463   Responsible for pages:5   Language:Japanese Book type:Scholarly book

  2. 気管支原性嚢胞 呼吸器症候群(第3版) –その他の呼吸器疾患を含めて- Ⅰ III閉塞性肺疾患、気管支の異常 B.嚢胞性肺疾患、気管支異常 別冊日本臨牀 新領域別症候群シリーズ No.17

    川部 勤( Role: Sole author)

    日本臨牀社  2021.8 

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    Total pages:463   Responsible for pages:5   Language:Japanese Book type:Scholarly book

  3. 疫学コア講義、改訂第4版 臨床免疫学編 アレルギー(アナフィラキシー、薬物アレルギー、食物アレルギー、アレルギー性鼻炎、花粉症、アレルギー性結膜疾患、血清病)

    編集, 熊ノ郷淳, 阪口薫雄, 竹田 潔, 吉田裕樹( Role: Joint author)

    南山堂  2017.11  ( ISBN:978-4-525-16754-7

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    Total pages:309   Language:Japanese Book type:Textbook, survey, introduction

  4. 「東海支部の歴史」 アレルギア 創立50周年記念特別号

    川部 勤 ( Role: Sole author)

    公益財団法人日本アレルギー協会  2017.10 

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    Total pages:4   Language:Japanese

  5. 免疫ペディア 5章 アレルギー Keyword6 花粉症 

    川部 勤 (熊ノ郷 淳/編)( Role: Joint author)

    羊土社  2017.7  ( ISBN:978-4-7581-2080-7

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    Total pages:317   Language:Japanese

  6. 免疫ペディア 5章 アレルギー Keyword5 ステロイド薬

    川部 勤 (熊ノ郷 淳/編)( Role: Joint author)

    羊土社  2017.7  ( ISBN:978-4-7581-2080-7

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    Total pages:317   Language:Japanese

  7. 連載「記憶に残る症例(39)」好酸球性肺疾患症例の回想

    川部 勤 ( Role: Sole author)

    アレルギー・免疫 医師薬ジャーナル  2017.6 

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    Total pages:4   Language:Japanese

  8. アレルギー・免疫

    川部 勤( Role: Sole author ,  連載「記憶に残る症例(39)」好酸球性肺疾患症例の回想)

    医師薬ジャーナル  2017.6 

  9. 『呼吸』エッセンシャルズ;呼吸疾患のピットフォール 肺酸素中毒症について

    監修:福地義之助、檀原 高( Role: Joint author)

    一般社団法人 呼吸研究  2015.1 

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    肺酸素中毒症について

  10. 呼吸管理Q&A 研修医からの質問331、第3版

    監修:相馬一亥、岡元和文( Role: Joint author)

    医学書院  2014.4 

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    第14章 II.O2療法 加温・加湿 酸素療法の危険性について(含酸素中毒)

  11. 特集 最新センサー材料・技術の開発事例 センサー機能を持つ織物の開発

    水野寛隆、鈴木陽久、榎堀 優、間瀬健二、水上祐樹、池口達治、川部 勤、佐藤一雄( Role: Joint author)

    工業材料  2013.12 

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    Language:Japanese

  12. 基礎医学-人体の構造と機能 (標準臨床検査学)  第13章呼吸器系

    編集, 岩谷良則( Role: Joint author)

    医学書院  2013.10  ( ISBN:4260017535

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  13. ピットホール 肺酸素中毒症について  「呼吸」

    川部 勤 ( Role: Sole author)

    レスピレーションリサーチファンデーション  2013.4 

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  14. 第59回学術集会 シンポジウム2:免疫反応と輸血(1) 司会のことば 臨床病理

    川部 勤, 松下 正( Role: Joint author)

    日本臨床検査医学会  2013 

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    Language:Japanese

  15. 疫学コア講義、改訂第3版 臨床免疫学編 アレルギー(アナフィラキシー、薬物アレルギー、食物アレルギー、アレルギー性鼻炎、花粉症、アレルギー性結膜疾患、血清病)

    編集, 熊ノ郷淳, 阪口薫雄, 竹田 潔, 吉田裕樹( Role: Joint author)

    南山堂  2012.11  ( ISBN:978-4-525-16753

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  16. CD40遺伝子欠損と続発性肺胞蛋白症

    芝崎正崇, 川部勤, 長谷川好規( Role: Joint author)

    呼吸 レスピレーションリサーチファンデーション  2010 

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  17. 喘息と遺伝学 気管支喘息治療におけるファーマコゲノミクス International Review of Asthma

    川部 勤,長谷川好規( Role: Sole author)

    メディカルレビュー社  2009.5 

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  18. 肺酸素中毒症 呼吸器症候群(第2版)–その他の呼吸器疾患を含めて- IⅠ IV 呼吸不全、換気異常 A.呼吸不全 別冊日本臨牀 新領域別症候群シリーズ No.8

    川部 勤( Role: Sole author)

    日本臨牀社  2009.2 

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  19. 呼吸器領域における光干渉断層計(optical coherence tomography)の可能性

    川部 勤,西澤典彦,北辻真史,大島博嘉( Role: Joint author)

    現代医学  2009.2 

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  20. 気管支原性嚢胞 呼吸器症候群(第2版) –その他の呼吸器疾患を含めて- Ⅰ III閉塞性肺疾患、気管支の異常 B.嚢胞性肺疾患、気管支異常 別冊日本臨牀 新領域別症候群シリーズ No.8

    川部 勤( Role: Sole author)

    日本臨牀社  2008.12 

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    Language:Japanese

  21. CD40ノックアウトマウス

    川部 勤( Role: Sole author)

    分子呼吸器病 先端医学社  2005.5 

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  22. テオフィリンの薬物動態に影響を与える因子、喘息治療におけるテオフィリン薬

    高木健三, 川部 勤,長谷川高明 監修:宮本 昭正、真野 健次( Role: Joint author)

    メディカルレビュー社  2005.2 

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  23. やり直し!基礎医学Q&A part2 炎症反応のしくみ

    川部 勤, 長瀬文彦( Role: Joint author)

    月刊ナ-シング 学習研究社  2005.2 

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  24. 第1章感染症の基礎知識 2.宿主の防御機構

    川部 勤( Role: Sole author)

    感染症 メディカルレビュー社  2000 

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    Language:English

  25. Leucocyte typing V, Generarion and characterization of CD40 deficient mice

    Kawabe T, Naka T, Yoshida K, Yoshida N, Kishimoto T, Kikutani H. ( Role: Joint author)

    Leucocyte typing V, Oxford University Press  1996 

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  26. CD40欠損マウスにおける免疫反応

    川部 勤,鎌仲正人,安居輝人, 菊谷 仁( Role: Joint author)

    Molecular Medicine 免疫 1995-96  1995 

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  27. CD40欠損マウスにおける免疫反応

    川部 勤, 鎌仲正人, 安居輝人, 菊谷 仁( Role: Joint author)

    Molecular Medicine 免疫 1995-96  1995 

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    Responsible for pages:30-40   Language:English

    researchmap

  28. T-B細胞間相互作用におけるCD40の重要性

    川部 勤,鎌仲正人,菊谷 仁( Role: Joint author)

    実験医学 増刊  1993 

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  29. 免疫(1993-1994) 免疫学アトラス T-B細胞間相互作用に関する膜分子

    川部 勤,菊谷 仁( Role: Joint author)

    中山書店  1993 

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    Language:Japanese

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Presentations 236

  1. Involvement of p62 on Activation of Heme Oxygenase-1 Induced by Quercetin

    Yuki Hayashi, Miyoko Matsushima, Goki Inoue, Ko Iwaki, Teppei Yamashita, Moeko Ohara, Hikaru Tsuzuki, Tsutomu Kawabe

    2021.12.8 

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    Event date: 2021.12

    Language:English   Presentation type:Poster presentation  

  2. Effects of localization changes of caveolin-1 on cellular function induced by quercetin

    Hikaru Tsuzuki, Miyoko Matsushima, Goki Inoue, Ko Iwaki, Yuki Hayashi, Teppei Yamashita, Moeko Ohara, Tsutomu Kawabe

    2021.12.8 

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    Event date: 2021.12

    Language:English   Presentation type:Poster presentation  

  3. Attenuation of signal transduction induced by diazinon in RBL-2H3 cells

    Goki Inoue, Miyoko Matsushima, Ko Iwaki, Yuki Hayashi, Teppei Yamashita, Moeko Ohara, Hikaru Tsuzuki, Tsutomu Kawabe

    2021.12.9 

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    Event date: 2021.12

    Language:English   Presentation type:Poster presentation  

  4. Investigation of B-cell differentiation on atopic dermatitis model mice

    Moeko Ohara, Miyoko Matsushima, Hikaru Tsuzuki, Goki Inoue, Ko Iwaki, Yuki Hayashi, Teppei Yamashita, Tsutomu Kawabe

    2021.12.9 

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    Event date: 2021.12

    Language:English   Presentation type:Poster presentation  

  5. Effects on function of macrophages by diazinon-modified metabolic status

    Ko Iwaki, Miyoko Matsushima, Goki Inoue, Yuki Hayashi, Teppei Yamashita, Moeko Ohara, Hikaru Tsuzuki, Tsutomu Kawabe

    2021.12.10 

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    Event date: 2021.12

    Language:English   Presentation type:Poster presentation  

  6. Analysis of efferocytosis on type 2-skewed immune responses in NC/Nga mice

    Teppei Yamashita, Miyoko Matsushima, Goki Inoue, Ko Iwaki, Yuki Hayashi, Moeko Ohara, Hikaru Tsuzuki, Tsutomu Kawabe

    2021.12.10 

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    Event date: 2021.12

    Language:English   Presentation type:Poster presentation  

  7. 呼吸の物理量情報をもとに評価する心肺機能 Invited

    川部 勤、松島充代子、長谷川 信、長谷川義大、式田光宏

    第 58 回日本臨床生理学会総会  2021.11.13 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  8. 肥満細胞の即時型および遅発型反応に対するダイアジノンの免疫修飾作用

    岩城 巧, 松島充代子, 坪﨑由夏, 小原萌恵子, 竹腰正広, 井上剛希, 川部 勤

    第51回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  9. 呼気解析からわかること、わかるといいと思うこと

    川部 勤

    日本分析化学会中部支部 2020年度 愛知地区講演会 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  10. Modulatory effects of diazinon on mast cell activation. International conference

    Miyoko Matsushima, Kazuko Atsumi, Moeko Ohara, Masahiro Takekoshi, Yuka Tsubosaki, Goki Inoue, Ko Iwaki, Yuki Hayashi, Teppei Yamashita, Tsutomu Kawabe.

    JSA/WAO XXVII World Allergy Congress (WAC 2020) conjoint with the APAPARI 2020 Congress.  

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    Event date: 2020.9

    Language:English   Presentation type:Poster presentation  

  11. 呼吸に伴い変化する物理量の解析から得られる生体情報の意義についての検討

    川部 勤, 松島充代子, 橋本直純, 佐藤光夫, 長谷川好規, 長谷川 信, 長谷川義大, 式田光宏

    第60回日本呼吸器学会学術講演会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  12. 呼気分析を応用した非侵襲的治療薬物モニタリングシステムの検討

    川部 勤, 松島充代子, 橋本直純, 佐藤光夫, 長谷川好規, 山本良平, 山本 敦

    第60回日本呼吸器学会学術講演会 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  13. DEVELOPMENT OF STENT FLOW SENSOR DEVICE EVALUATING BREATHING PROPERTY AT AIRWAY IN EXPERIMENTAL ANIMAL UNDER FREE MOVE CONDITION International conference

    Noma Hayato, Hasegawa Yoshihiro, Taniguchi Kazuhiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

    2020 33RD IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2020) 

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    Event date: 2020

    Language:English   Presentation type:Poster presentation  

  14. Wavelength dependence of ultrahigh resolution optical coherence tomography using supercontinuum International conference

    Nishizawa Norihiko, Yamanaka Masahito, Kawagoe Hiroyuki, Matsushima Miyoko, Mori Kensaku, Kawabe Tsutomu

    OPTICAL BIOPSY XVIII: TOWARD REAL-TIME SPECTROSCOPIC IMAGING AND DIAGNOSIS 

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    Event date: 2020

    Language:English  

  15. Analysis of B cell differentiation in NC/Nga mice

    Masahiro Takekoshi, Miyoko Matsushima, Kyohka Tanaka, Yuka Tsubosaki, Tsutomu Kawabe.

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  16. The effects of widely-used neonicotinoid insecticides on macrophage function

    Yuka Tsubosaki, Miyoko Matsushima, Kyohka Tanaka, Masahiro Takekoshi, Tsutomu Kawabe.

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    Event date: 2019.12

    Language:English   Presentation type:Poster presentation  

  17. 実験動物における気道内流量計測を目的としたステント型流量センサの開発

    野間 颯斗, 長谷川 義大, 谷口 和弘, 松島 充代子, 川部 勤, 式田 光宏 

    第36回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2019.11

    Language:Japanese  

  18. 銅張積層板を用いた流路構造一体型 MEMS 流量センサの開発

    瀧川 流成, 長谷川 義大, 谷口 和弘, 松島 充代子, 川部 勤, 式田 光宏

    第36回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2019.11

    Language:Japanese  

  19. フレキシブル基板上での MEMS 流量センサと信号処理回路との一体化に関する研究

    加藤 絢美, 藤綱 伊織, 長谷川 義大, 谷口 和弘, 松島 充代子, 川部 勤、式田 光宏

    第36回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2019.11

    Language:Japanese  

  20. 点滴システムへの応用を目指したマイクロ流量センサの開発

    下平 千尋, 長谷川 義大, 谷口 和弘, 松島 充代子, 川部 勤, 式田 光宏

    第36回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2019.11

    Language:Japanese  

  21. 経気管支的に呼吸および光学画像計測を可能とするカテーテルセンサシステムに関する研究

    前田 佳史, 長谷川 義大, 谷口 和弘, 松島 充代子, 川部 勤, 式田 光宏

    第36回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2019.11

    Language:Japanese  

  22. Development of Breathing Monitoring System for Artificial Ventilator in Animal Experiment. International conference

    H. Yoshida, Y. Hasegawa, K. Taniguchi, M. Matsushima, T. Kawabe, M. Shikida.

    32nd International Microprocesses and Nanotechnology Conference (MNC2019) 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  23. Effects of acetamiprid on Toll-like receptor 7-mediated inflammation International conference

    Hayashi Y., Matsushima M., Takekoshi M., Saso K., Tanaka K., Tsubosaki Y., Inoue G., Iwaki K., Yamashita T., Kawabe T.

    IUIS2019 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  24. Suppressive effects of flavonoids on T cell activation International conference

    Tsubosaki Y., Matsushima M., Sugiyama T., Tanaka K., Takekoshi M., Inoue G., Iwaki K., Hayashi Y., Yamashita T., Kawabe T.

    IUIS2019 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  25. Modification of allergic inflammation in murine model of allergic conjunctivitis without CD40 signal International conference

    Iwaki K., Matsushima M., Kawabe M., Mizutani M., Tsubosaki Y., Takekoshi M., Tanaka K., Inoue G., Hayashi Y., Yamashita T., Kawabe T.

    IUIS2019 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  26. Lung inflammation is attenuated by intratracheal administration of quercetin International conference

    Inoue G., Matsushima M., Takashima K., Tanaka K., Takekoshi M., Tsubosaki Y., Iwaki K., Hayashi Y., Yamashita T., Kawabe T.

    IUIS2019 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  27. Evaluation of IgM autoantibody in autoimmune hemolytic anemia International conference

    Takekoshi M., Matsushima M., Tanaka K., Inoue G., Tsubosaki Y., Iwaki K., Hayashi Y., Yamashita T., Kawabe T.

    IUIS2019 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  28. Quercetin-induced cytoprotective action by modification of cell membrane International conference

    Matsushima M., Nose H., Kusatsugu Y., Tanaka K., Takekoshi M., Tsubosaki Y., Inoue G., Iwaki K., Hayashi Y., Yamashita T., Kawabe T.

    IUIS2019 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

  29. Flow sensor and stent integration for evaluating in-situ breathing property at airway in experimental animal. International conference

    H. Noma, Y. Hasegawa, K. Taniguchi, M. Matsushima, T. Kawabe, M. Shikida

    Tech. Dig. of 45th International Conference on Micro & Nano Engineering (MNE2019) 

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    Event date: 2019.9

    Language:English   Presentation type:Poster presentation  

  30. MICRO-MACHINEED CATHETER SENSOR SYSTEMATIZATION FOR IN-SITU BREATHING AND OPTICAL IMAGING MEASUREMENTS IN BRONCHUS REGION IN LUNG SYSTEM International conference

    Maeda Yoshifumi, Okihara Chiaki, Hasegawa Yoshihiro, Taniguchi Kazuhiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

    Tech. Dig. of 45th International Conference on Micro & Nano Engineering (MNE2019) 

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    Event date: 2019.9

    Language:English   Presentation type:Poster presentation  

  31. A thermal flow sensor and its signal processing circuit integration onto flexible copper on polyimide substrate. International conference

    A. Kato, Y. Hasegawa, K. Taniguchi, M. Matsushima, T. Kawabe, M. Shikida.

    Tech. Dig. of 45th International Conference on Micro & Nano Engineering (MNE2019) 

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    Event date: 2019.9

    Language:English   Presentation type:Poster presentation  

  32. The role of innate immunity on type 2 immune response in bronchial asthma. International conference

    TAKEKOSHI Masahiro, MATSUSHIMA Miyoko, YAMASHITA Teppei, INOUE Goki, IWAKI Ko, HAYASHI Yuki, TANAKA Kyohka, TSUBOSAKI Yuka, KAWABE Tsutomu

    28th Congress of Interasthma Japan North Asia 

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation (general)  

  33. Thermal flow sensor operated under 40 degrees Celsius for controlling small dosing rate in drip infusion system International conference

    C. Shimohira, Y. Hasegawa, K. Taniguchi, M. Matsushima, T. Kawabe, M. Shikida.

    Tech. Dig. of 45th International Conference on Micro & Nano Engineering (MNE2019) 

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    Event date: 2019.9

    Language:English   Presentation type:Poster presentation  

  34. ラット呼気からの薬物排泄量と肺組織内薬物濃度との相関

    岩出真歩, 日下部純平, 中島花奈, 山本良平, 山本敦, 松島充代子, 川部 勤

    日本分析化学会 第68年会 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Poster presentation  

  35. MEMS技術を用いた動物用人工呼吸器計測評価システムの開発

    吉田誉, 長谷川義大, 谷口和弘, 式田光宏, 松島充代子, 川部勤

    生体医工学シンポジウム2019 

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    Event date: 2019.9

    Language:Japanese  

  36. 呼吸にもとづいた生体情報計測技術の開発

    LEE SEUNGHYEON, 長谷川義大, 谷口和弘, 式田光宏, 松島充代子, 川部勤

    生体医工学シンポジウム2019 

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    Event date: 2019.9

    Language:Japanese  

  37. 環境物質としての農薬による健康被害についてのin vitro評価‐ネオニコチノイド系農薬の場合‐

    坪崎由夏, 松島充代子, 林 祐希, 竹腰正広, 田中杏佳、井上剛希, 岩城 巧, 山下哲平, 上山 純,川部 勤

    第14回臨床検査学教育学会学術大会 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  38. 自己免疫性溶血性貧血の発症における自己抗体のアイソタイプの意義

    竹腰正広, 松島充代子, 井上剛希, 田中杏佳, 坪崎由夏, 岩城 巧, 林 祐希, 山下哲平, 川部 勤

    第14回臨床検査学教育学会学術大会 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  39. アセタミプリドが気道系の免疫応答に及ぼす影響についての評価

    坪崎由夏, 松島充代子, 林 祐希, 竹腰正広, 田中杏佳、井上剛希, 岩城 巧, 山下哲平, 上山 純,川部 勤

    第50回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  40. フラボノイドがT細胞のIL-2の産生および細胞増殖に及ぼす効果

    松島充代子, 川部 勤

    第68回日本アレルギー学会学術大会 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Poster presentation  

  41. 動物実験用人工呼吸器計測評価システムの開発

    吉田誉, 長谷川義大, 谷口和弘, 式田光宏, 松島充代子, 川部勤

    平成31年電気学会全国大会 

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    Event date: 2019.3

    Language:Japanese  

  42. 気道内留置可能なステント型流量センサの開発

    野間颯斗, 長谷川義大, 谷口和弘, 式田光宏, 松島充代子, 川部勤

    平成31年電気学会全国大会 

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    Event date: 2019.3

    Language:Japanese  

  43. 流路構造付きMEMS流量センサの開発

    瀧川流成, 長谷川義大, 谷口和弘, 式田光宏, 松島充代子, 川部勤

    平成31年電気学会全国大会 

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    Event date: 2019.3

    Language:Japanese  

  44. 滴投与量計測用マイクロ流量センサの開発

    下平千尋, 長谷川義大, 谷口和弘, 式田光宏, 松島充代子, 川部勤

    平成31年電気学会全国大会 

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    Event date: 2019.3

    Language:Japanese  

  45. INTEGRATION OF MEMS FLOW SENSOR, ELECTRICAL WIRING, AND TUBE STRUCTURE ONTO COPPER ON POLYIMIDE SUBSTRATE International conference

    Takigawa Ryusei, Hasegawa Yoshihiro, Taniguchi Kazuhiro, Matsushima Miyoko, Kawabe Tsutomu, Shikida Mitsuhiro

    2019 20TH INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS & EUROSENSORS XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) 

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    Event date: 2019

    Language:English   Presentation type:Poster presentation  

  46. Diazinon-induced dysregulation of mast cell function

    Kyohka Tanaka, Miyoko Matsushima, Kanako Sasou, Tsutomu Kawabe.

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

  47. Modification of immune function by neonicotinoid and organophosphorus insecticides.

    Miyoko Matsushima, Kanako Sasou, Kyohka Tanaka, Tsutomu Kawabe.

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    Event date: 2018.12

    Language:English   Presentation type:Poster presentation  

  48. シンポジウムVII:光コヒーレンストモグラフィ(optical coherence tomography)を用いたイメージングと形態計測による肺組織の評価について Invited

    川部 勤, 松島充代子, 西澤典彦

    第39回日本レーザー医学会総会 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京都   Country:Japan  

  49. 光コヒーレンストモグラフィ(optical coherence tomography)を用いたイメージングと形態計測による肺組織の評価について

    川部 勤, 松島充代子, 西澤典彦

    第39回日本レーザー医学会総会 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  50. Micro-machined flow sensor formed on copper on polyimide substrate and its respiration measurement application. International conference

    A. Kato, Y. Hasegawa, K. Taniguchi, M. Mastushima, T. Kawabe, M. Shikida.

    31st International Microprocesses and Nanotechnology Conference (MNC2018) 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  51. Development of three layered tube type flow sensor for human respiration measurement

    Y. Mitsunari, S. Watanabe, Y. Hasegawa, M. Matsushima, T. Kawabe, M. Shikida.

    31st International Microprocesses and Nanotechnology Conference (MNC2018) 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

  52. 感温フィルムを用いた簡易的呼吸検知デバイスの開発

    前田佳史, 長谷川義大, 谷口和弘, 松島充代子, 川部勤, 式田光宏

    第35回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2018.10

    Language:Japanese  

  53. 呼吸と体温の両計測が可能なMEMS流量センサの開発

    藤範知弘, 長谷川義大, 谷口和弘, 松島充代子, 川部勤, 式田光宏

    第35回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2018.10

    Language:Japanese  

  54. 乳幼児の呼吸心拍一括計測を目指した気管挿管チューブ実装型MEMS流量センサシステムに関する研究

    光成勇樹, 長谷川義大, 松島充代子, 川部 勤, 式田光宏

    第35回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2018.10

    Language:Japanese  

  55. 銅張積層板を用いた温度補償機能搭載型MEMS呼吸センサの開発

    加藤絢美, 長谷川義大, 谷口和弘, 松島充代子, 川部勤, 式田光宏

    第35回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2018.10

    Language:Japanese  

  56. シンポジウム:Functional Bronchoscopy:気管支鏡検査と呼吸生理: Functional Bronchology 生理機能ならびに形態計測による末梢気道評価について呼吸器内視鏡の可能性 Invited

    川部 勤

    第23回呼吸器インターベンションセミナー 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川県足柄下郡箱根町湯本   Country:Japan  

  57. 農薬によって修飾される免疫応答についての基礎的検討

    佐宗香奈子, 松島充代子, 渥美和子, 田中杏佳, 上山 純, 川部 勤

    第13回臨床検査学教育学会学術大会 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  58. 肥満細胞の活性化に及ぼすダイアジノンの効果についての基礎的検討

    佐宗香奈子, 松島充代子, 渥美和子, 田中杏佳, 杉山燈人, 大立知子, 上山 純, 川部 勤

    第49回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  59. Effects of diazinon on mast cell activation International conference

    TANAKA Kyohka, MATSUSHIMA Miyoko, ATSUMI Kazuko, SASOU Kanako, SUGIYAMA Tomoshi, OHDACHI Tomoko, UEYAMA Jun, HASHIMOTO Naozumi, KAWABE Tsutomu

    18th World Congress of Basic and Clinical Pharmacology 

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    Event date: 2018.7

    Language:English   Presentation type:Poster presentation  

  60. Effects of neonicotinoid and organophosphorus insecticides on macrophage functions. International conference

    SASOU Kanako, MATSUSHIMA Miyoko, OGASAWARA Nanako, OHDACHI Tomoko, ATSUMI Kazuko, TANAKA Kyohka, SUGIYAMA Tomoshi, UEYAMA Jun, HASHIMOTO Naozumi, KAWABE Tsutomu.

    18th World Congress of Basic and Clinical Pharmacology 

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    Event date: 2018.7

    Language:English   Presentation type:Poster presentation  

  61. Breathing monitoring by energy-less respiration sensor based on thermo-sensitive film. International conference

    Y. Maeda, Y. Hasegawa, K. Taniguchi, M. Matsushima, T. Kawabe, M. Shikida.

    Tech. Dig. of Asia-Pacific Conference on Transducers and Micro-Nano Technology 

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    Event date: 2018.6

    Language:English   Presentation type:Poster presentation  

  62. MEMS Flow Sensor Integration into Tracheal Tube Device and its Application to Respiration and Heartbeat Signal Detection in Infant. International conference

    Y. Mitsunari, Y. Hasegawa, M. Matsushima, T. Kawabe, M. Shikida.

    Tech. Dig. of Asia-Pacific Conference on Transducers and Micro-Nano Technology 

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    Event date: 2018.6

    Language:English   Presentation type:Poster presentation  

  63. 農薬が肥満細胞の活性化に与える影響についての基礎的検討

    松島充代子, 川部 勤

    第67回日本アレルギー学会学術大会 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Poster presentation  

  64. 呼気を使った TDM の可能性―ラット呼気量を補正 するための指標物質の探索

    日下部純平, 小西真菜香, 山本良平, 山本 敦, 松島充代子, 川部 勤

    日本薬学会第138回年会 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Poster presentation  

  65. Deteriorated amount of IC capture without CD40 on B cells

    第46回日本免疫学会 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:仙台国際センター   Country:Japan  

  66. Analysis on signal pathway in pro-inflammatory response by diazinon

    第46回日本免疫学会 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:仙台国際センター   Country:Japan  

  67. 乳幼児の口元気流計測を目的とした熱式チューブ型マイクロ流量センサの開発

    光成勇樹、長谷川義大、松島充代子、川部 勤、式田光宏

    第34回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2017.10 - 2017.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:広島国際会議場   Country:Japan  

  68. 末梢気道におけるその場観察と呼吸量計測を可能とする光ファイバースコープ搭載型流量センサの開発

    沖原千明、長谷川 義大、松島充代子、川部 勤、式田 光宏

    第34回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2017.10 - 2017.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:広島国際会議場   Country:Japan  

  69. 気流検出機能付気管チューブシステムとそれによるその場呼吸計測法に関する研究

    渡辺 瞬、長谷川義大、松島充代子、川部 勤、式田光宏

    第34回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2017.10 - 2017.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:広島国際会議場   Country:Japan  

  70. 経気管支的に肺機能計測が可能な気管支径対応カテーテル型流量センサの開発

    藤範知弘、長谷川義大、松島充代子、川部 勤、式田光宏

    第34回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2017.10 - 2017.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:広島国際会議場   Country:Japan  

  71. Micromachined tube type thermal flow sensor for adult-sized tracheal intubation tube International conference

    Eurosensors2017 

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    Event date: 2017.9

    Language:English   Presentation type:Poster presentation  

    Venue:UICP Conference Center   Country:France  

  72. Development of catheter flow sensor for breathing measurements at different levels of tracheobronchial airway International conference

    Eurosensors2017 

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    Event date: 2017.9

    Language:English   Presentation type:Poster presentation  

    Venue:UICP Conference Center   Country:France  

  73. Development of small-footprint thermal sensor detecting airflow at mouth in baby International conference

    Eurosensors2017 

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    Event date: 2017.9

    Language:English   Presentation type:Poster presentation  

    Venue:UICP Conference Center   Country:France  

  74. ダイアジノンは骨髄由来マクロファージを活性化させ、免疫応答を修飾する

    渥美和子、松島充代子、小笠原名奈子、佐宗香奈子、上山 純、川部 勤

    第48回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2017.6 - 2017.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:AOSSA   Country:Japan  

  75. Integration of flow sensor and optical fiberscope for in-situ breathing and surface image evaluations in small airway International conference

    19th International Conference on Solid-State Sensors, Actuators and Microsystems 

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    Event date: 2017.6

    Language:English   Presentation type:Poster presentation  

    Venue:Kaohsiung Exhibition Center   Country:Taiwan, Province of China  

  76. 農薬が免疫機能に与える影響についての基礎的検討

    松島充代子、川部 勤

    第66回日本アレルギー学会学術大会 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京国際フォーラム   Country:Japan  

  77. 呼気エアロゾルを代替血液とした TDM は可能か?

    谷畑壮磨、山本良平、山本 敦、東海林秀典、加藤祐史、下内章人、松島充代子、川部 勤

    日本薬学会第137回年会 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台国際センター   Country:Japan  

  78. 分子標的薬のための選択的吸着剤開発

    大澤磨未、高井里奈、山本良平、山本 敦、松島充代子、川部 勤

    日本薬学会第137回年会 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:仙台国際センター   Country:Japan  

  79. ケルセチンによるNrf2活性化におけるcaveolin-1の局在変化の関与

    第90回日本薬理学会年会 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:長崎ブリックホール、長崎新聞文化ホール アストピア   Country:Japan  

  80. The Induction of Macrophage Activation by Diazinon

    第45回日本免疫学会 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:沖縄コンベンションセンター、ラグナガーデンホテル   Country:Japan  

  81. Somatic hypermutation is not altered without CD40 signaling in T-B interaction

    第45回日本免疫学会 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:沖縄コンベンションセンター、ラグナガーデンホテル   Country:Japan  

  82. Effect of guide tube length on sensor output in inspired airflow measurement International conference

    29th International Microprocesses and Nanotechnology Conference 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Venue:ANA Crowne Plaza Kyoto   Country:Japan  

  83. Breathing signal analysis of mouse during drug inhalation International conference

    29th International Microprocesses and Nanotechnology Conference 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Venue:ANA Crowne Plaza Kyoto   Country:Japan  

  84. Measurement of heartbeat signals from airflow at mouth in rat by catheter flow sensor International conference

    IEEE Sensors 2016 

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    Event date: 2016.10 - 2016.11

    Language:English   Presentation type:Poster presentation  

    Venue:Caribe Royale All-Suite Hotel and Convention Center   Country:United States  

  85. Development of cylinder hollow structure with flow sensor by film transfer technology International conference

    IEEE Sensors 2016 

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    Event date: 2016.10 - 2016.11

    Language:English   Presentation type:Poster presentation  

    Venue:Caribe Royale All-Suite Hotel and Convention Center   Country:United States  

  86. 心拍信号検出を目的とした温度補償機能付カテーテル型流量センサの開発

    河岡秀宜、山田貴之、松島充代子、川部 勤、長谷川義大、式田光宏

    第33回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:平戸文化センター   Country:Japan  

  87. 肺機能計測用カテーテル型流量センサの高速応答化に関する研究

    渡辺 瞬、長谷川義大、松島充代子、川部 勤、式田光宏

    第33回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:平戸文化センター   Country:Japan  

  88. 肺機能評価を目的としたバスケット鉗子搭載型MEMS流量センサの開発

    長谷川義大、原田直明、小野良太、松島充代子、川部 勤、式田光宏

    第33回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:平戸文化センター   Country:Japan  

  89. マルチ計測モードが可能なMEMS流量センサの開発

    藤範知弘、長谷川義大、松島充代子、川部 勤、式田光宏

    第39回日本生体医工学会中国四国支部大会 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島大学 常三島キャンパス   Country:Japan  

  90. 呼吸心拍測定を目指した温度補償機能付き熱式カテーテル型センサの開発

    光成勇樹、長谷川義大、松島充代子、川部 勤、式田光宏

    第39回日本生体医工学会中国四国支部大会 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島大学 常三島キャンパス   Country:Japan  

  91. 生体防御機構の誘導を指標とした有害物質の評価法の探索

    大薮沙也果、松島充代子、草次裕人、小笠原名奈子、武村和哉、越智 悠、渥美和子、川部 勤

    第11回臨床検査学教育学会学術大会 

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    Event date: 2016.8 - 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸常磐大学   Country:Japan  

  92. Involvement of CD40 on Immune Cells in Response to Immune Complexes International conference

    ATSUMI Kazuko, MATSUSHIMA Miyoko, OGISO Hiroki, OCHI Haruka, KUSATSUGU Yuto, OYABU Sayaka, OGASAWARA Nanako, TAKEMURA Kazuya, KAWABE Tsutomu

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    Event date: 2016.8

    Language:English   Presentation type:Poster presentation  

    Country:Australia  

  93. Involvement of CD40 in the Expression of Bcl6 International conference

    OCHI Haruka, MATSUSHIMA Miyoko, KODERA Yuka, KUSATSUGU Yuto, OYABU Sayaka, ATSUMI Kazuko, OGASAWARA Nanako, TAKEMURA Kazuya, KAWABE Tsutomu

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    Event date: 2016.8

    Language:English   Presentation type:Poster presentation  

    Country:Australia  

  94. Involvement of Caveolin-1 in Quercetin-Induced Nrf2 Activation International conference

    MATSUSHIMA Miyoko, KUSATSUGU Yuto, OYABU Sayaka, OCHI Haruka, ATSUMI Kazuko, OGASAWARA Nanako, TAKEMURA Kazuya, KAWABE Tsutomu

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    Event date: 2016.8

    Language:English   Presentation type:Poster presentation  

    Country:Australia  

  95. Quercetin Suppressed Imiquimod-Induced Activation of Alveolar Macrophages International conference

    OYABU Sayaka, MATSUSHIMA Miyoko , OMURA Aya, OGASAWARA Nanako, OCHI Haruka, KUSATSUGU Yuto, ATSUMI Kazuko, TAKEMURA Kazuya, KAWABE Tsutomu

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    Event date: 2016.8

    Language:English   Presentation type:Poster presentation  

    Country:Australia  

  96. Critical Role of Selective Autophagy Adaptor Protein p62 in Quercetin-Induced Nrf2 Activation International conference

    KUSATSUGU Yuto, MATSUSHIMA Miyoko, OYABU Sayaka, OCHI Haruka, ATSUMI Kazuko, OGASAWARA Nanako, TAKEMURA Kazuya, KAWABE Tsutomu

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    Event date: 2016.8

    Language:English   Presentation type:Poster presentation  

    Country:Australia  

  97. Response time shortening in thermal catheter flow sensor International conference

    Asia-Pacific Conference on Transducers and Micro-Nano Technology 

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    Event date: 2016.7

    Language:English   Presentation type:Poster presentation  

    Venue:Kanazawa Bunka Hall   Country:Japan  

  98. 農薬の環境曝露が免疫機能に及ぼす影響についての基礎的検討

    渥美和子、松島充代子、小笠原名奈子、武村和也、越智 悠、草次裕人、大薮沙也果、上山 純、川部 勤

    第47回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:近畿大学11月ホール   Country:Japan  

  99. 症状発現の推測を目論む血清IgEを用いたI型アレルギー検査法の検討

    松島充代子、川部 勤

    第65回日本アレルギー学会学術大会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京国際フォーラム   Country:Japan  

  100. 呼気を使った非侵襲的TDM-呼気エアロゾルの構造

    谷畑壮磨、山本良平、山本 敦、越智 悠、草次裕人、松島充代子、川部 勤

    第33回日本TDM学会・学術大会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:栃木県総合文化センター   Country:Japan  

  101. Micro flow sensor integration onto basket forceps for pulmonary function evaluation International conference

    11th IEEE Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) 

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    Event date: 2016.4

    Language:English   Presentation type:Poster presentation  

    Venue:Matsushima Bay and Sendai MEMS City   Country:Japan  

  102. Detection of kinetic heartbeat signals from airflow at mouth by catheter flow sensor with temperature compensation. International conference

    KAWAOKA Hidenori, YAMADA Takayuki, MATSUSHIMA Miyoko , KAWABE Tsutomu, HASEGAWA Yoshinori, SHIKIDA Mitsuhiro

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    Event date: 2016.1

    Language:English   Presentation type:Poster presentation  

    Country:China  

  103. 呼吸心拍検出を目的とした温度補償機能付MEMS流量センサの開発

    河岡秀宜、山田貴之、松島充代子、川部 勤、長谷川義大、式田光宏

    第38回日本生体医工学会中国四国支部大会 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島市立大学   Country:Japan  

  104. 呼吸器系疾患の精密診断を目的としたバスケット鉗子実装型MEMSセンサの開発

    原田直明、小野良太、松島充代子、川部 勤、長谷川義大、式田光宏

    第38回日本生体医工学会中国四国支部大会 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:広島市立大学   Country:Japan  

  105. The role of CD40 on immune responses against immune complex

    OGISO Hiroki, MATSUSHIMA Miyoko, OOMURA Aya, OCHI Haruka, KUSATSUGU Yuto, KAWABE Tsutomu

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    Event date: 2015.11

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  106. The involvement of autophagy on quercetin-induced Nrf2 activation

    KUSATSUGU Yuto, MATSUSHIMA Miyoko, OOMURA Aya, OGISO Hiroki, OCHI Haruka, KAWABE Tsutomu

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    Event date: 2015.11

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  107. Responsible time shorting of flexible thermal flow sensor for medical applications International conference

    IMAEDA Kodai, SHIBATA Shunji, MATSUSHIMA Miyoko , KAWABE Tsutomu, SHIKIDA Mitsuhiro

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    Event date: 2015.11

    Language:English   Presentation type:Poster presentation  

    Country:Korea, Republic of  

  108. Extraction of heartbeat signal from airflow at mouth by flow sensor International conference

    KAWAOKA Hidenori, YAMADA Takayuki, MATSUSHIMA Miyoko , KAWABE Tsutomu, HASEGAWA Yoshinori, SHIKIDA Mitsuhiro

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    Event date: 2015.11

    Language:English   Presentation type:Poster presentation  

    Country:Korea, Republic of  

  109. 多波長帯OCTイメージングによるラット肺組織の3次元解析

    安藤栄充,川越寛之,山中真仁,松島充代子,森 健策,川部 勤,西澤典彦

    日本光学会年次学術講演会Optics & Photonics Japan 2015 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:筑波大学東京キャンパス文京校舎   Country:Japan  

  110. MEMSカテーテル型流量センサを用いた呼吸心拍機能検出

    河岡秀宜、山田貴之、松島充代子、川部 勤、長谷川義大、式田光宏

    日本機械学会マイクロ・ナノ工学部門, 第7回 マイクロ・ナノ工学シンポジウム 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:朱鷺メッセ   Country:Japan  

  111. 気道内固定機能付きMEMS流量センサの開発

    原田直明、小野良太、松島充代子、川部 勤、長谷川義大、式田光宏

    日本機械学会マイクロ・ナノ工学部門, 第7回 マイクロ・ナノ工学シンポジウム 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:朱鷺メッセ   Country:Japan  

  112. 呼気を用いた非侵襲的TDM法の探索

    越智 悠、松島充代子、小木曽寛希、大村 綾、草次裕人、日置清香、山本良平、井上嘉則、山本 敦、川部 勤

    第10回臨床検査学教育学会学術大会 

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    Event date: 2015.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:信州大学医学部地域保健推進センター他   Country:Japan  

  113. ガイダンス付スパイロメーターを用いた検査法の評価

    草次裕人、松島充代子、小木曽寛希、大村 綾、越智 悠、黒澤慎也、大崎理恵、川部 勤

    第10回臨床検査学教育学会学術大会 

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    Event date: 2015.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:信州大学医学部地域保健推進センター他   Country:Japan  

  114. Detection of both heartbeat and respiration signals from airflow at mouth using catheter flow sensor International conference

    KAWAOKA Hidenori, YAMADA Takayuki, MATSUSHIMA Miyoko , KAWABE Tsutomu, SHIKIDA Mitsuhiro

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    Event date: 2015.7

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  115. Basket forceps with flow sensor for evaluating breathing characteristics in small airway International conference

    HARADA Naoaki, ONO Ryota , MATSUSHIMA Miyoko , KAWABE Tsutomu, SHIKIDA Mitsuhiro

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    Event date: 2015.7

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  116. 有機リン系殺虫剤による免役応答修飾機構についての検討

    松島充代子、小笠原名奈子、河村奈美、山口剛広、高木健三、川部 勤

    第64回日本アレルギー学会学術大会 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:グランドプリンスホテル新高輪国際館パミール   Country:Japan  

  117. 肺機能経年変化に及ぼす長期作用型β2刺激薬の影響‐長期通院気管支喘息患者12症例の検討‐

    鈴木嘉洋、若原恵子、岡崎祥太郎、麻生裕紀、長谷哲也、伊藤 理、橋本直純、佐藤光夫、近藤征史、川部 勤、長谷川好規

    第64回日本アレルギー学会学術大会 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:グランドプリンスホテル新高輪国際館パミール   Country:Japan  

  118. ケルセチンのマウスARDSモデルに対する肺保護作用

    高嶋浩司、松島充代子、橋本克則、佐藤光夫、橋本直純、長谷川好規、川部 勤

    第55回日本呼吸器学会学術講演会 

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    Event date: 2015.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京国際フォーラム   Country:Japan  

  119. Different mechanism of cytoprotective effects by flavonoids, quercetin and chrysin.

    SHIGA Marika, MATSUSHIMA Miyoko, KODERA Yuka, OOMURA Aya, OGISO Hiroki, KAWABE Tsutomu

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    Event date: 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  120. The effect of diazinon on macrophage activation.

    OOMURA Aya, MATSUSHIMA Miyoko, KODERA Yuka, SHIGA Marika, OGISO Hiroki, KAWABE Tsutomu

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    Event date: 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  121. Protective effects of quercetin on lipopolysaccharide-induced acute lung injury.

    OGISO Hiroki, MATSUSHIMA Miyoko, KODERA Yuka, SHIGA Marika, OOMURA Aya, KAWABE Tsutomu

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    Event date: 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  122. The involvement of cell membrane changes in quercetin-induced cytoprotective effects.

    KODERA Yuka, MATSUSHIMA Miyoko, SHIGA Marika, OOMURA Aya, OGISO Hiroki, KAWABE Tsutomu

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    Event date: 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  123. SC光を用いたラット肺組織の3次元超高分解能OCTイメージングによる解析

    安藤栄充,川越寛之,服部雄治,山中真仁,松島充代子,高嶋浩司,長谷川好規,森健策,川部勤,西澤典彦

    日本光学会年次学術講演会Optics & Photonics Japan 2014 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:筑波大学東京キャンパス文京校舎   Country:Japan  

  124. 肥満細胞活性化に対するクリシンとケルセチンの抑制効果とその機序の相違

    大村 綾、松島充代子、志賀茉梨化、草次裕人、小笠原名奈子、武村和哉、小寺佑果、小木曽寛希、川部 勤

    第9回日本臨床検査学教育学会学術大会 

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    Event date: 2014.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大田区産業プラザ   Country:Japan  

  125. TLR7を介した肺胞マクロファージの活性化に対するケルセチンの効果

    小寺佑果、松島充代子、小笠原名奈子、武村和哉、志賀茉梨化、大村 綾、小木曽寛希、川部 勤

    第9回日本臨床検査学教育学会学術大会 

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    Event date: 2014.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大田区産業プラザ   Country:Japan  

  126. Effects of quercetin on TLR7-mediated macrophage activation International conference

    Aya Oomura, Miyoko Matsushima, Nanako Ogasawara, Kazuya Takemura, Yuka Kodera, Marika Shiga, Hiroki Ogiso, Tsutomu Kawabe

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    Event date: 2014.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  127. Inhibitory action of mast cell degranulation by chrysin International conference

    Marika Shiga, Miyoko Matsushima, Yuto Kusatsugu, Nanako Ogasawara, Kazuya Takemura, Yuka Kodera, Aya Oomura, Hiroki Ogiso, Tsutomu Kawabe

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    Event date: 2014.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  128. マクロファージの免疫調節機能に及ぼすダイアジノンの効果

    松島充代子、小笠原名奈子、河村奈美、武村和哉、小寺佑果、志賀茉梨花、大村 綾、小木曽寛希、上山 純、川部 勤

    第45回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡ソフトリサーチパーク(SRP)センタービル   Country:Japan  

  129. エアロゾル用吸着剤の開発と呼気中薬物分析への適用

    日置清香、三輪俊夫、山本良平、井上嘉則、山本 敦、松島充代子、川部 勤

    第21回クロマトグラフィーシンポジウム 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋市工業研究所   Country:Japan  

  130. 長期外来通院喘息症例における肺機能経年変化についての検討

    鈴木嘉洋、若原恵子、鈴木妙子、岡崎祥太郎、今井直幸、麻生裕紀、長谷哲也、橋本直純、伊藤 理、佐藤光夫、近藤征史、川部 勤、長谷川好規

    第26回日本アレルギー学会春季臨床大会 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:国立京都国際会館   Country:Japan  

  131. 非侵襲的治療薬物モニタリングのための呼気用新規吸着剤の開発

    日置清香、三輪俊夫、山本良平、井上嘉則、山本 敦、松島充代子、川部 勤

    日本薬学会第134年会 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:熊本市総合体育館   Country:Japan  

  132. The inhibitory effect of quercetin on TLR7-induced activation of alveolar macrophages

    Yuka Kodera, Miyoko Matsushima, Haruka Nose, Takehiro Yamaguchi, Marika Shiga, Tsutomu Kawabe

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  133. Chrysin suppresses mast cell activation via HO-1-independent pathway

    Marika Shiga, Miyoko Matsushima, Haruka Nose, Takehiro Yamaguchi, Yuka Kodera, Tsutomu Kawabe

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    Event date: 2013.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  134. 外来喘息症例における治療ステップダウンについての検討

    鈴木嘉洋、若原恵子、橋本直純、伊藤 理、佐藤光夫、近藤征史、川部 勤、長谷川好規

    第63回日本アレルギー学会秋季学術大会 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ホテルニューオータニ   Country:Japan  

  135. TLR7を介した肺胞マクロファージの活性化に対するケルセチンならびにその誘導するHO -1の効果について

    安井正宏、松島充代子、川部 勤

    第63回日本アレルギー学会秋季学術大会 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ホテルニューオータニ   Country:Japan  

  136. 環境物質曝露によるマクロファージの活性化に対するフラボノイドの効果とその機序

    山口剛広、松島充代子、川部 勤

    第63回日本アレルギー学会秋季学術大会 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ホテルニューオータニ   Country:Japan  

  137. 正常・疾患ラット肺組織の3次元超高分解能OCTイメージング

    服部雄治、川越寛之、石田周太郎、荒巻光利、西澤典彦、松島充代子、高嶋浩司、長谷川好規、川部勤

    日本光学会年次学術講演会Optics & Photonics Japan 2013 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:奈良   Country:Japan  

  138. SpiroVest: an e-textile-based wearable spirometer with posture change adaptability International conference

    Enokibori Y., Ito Y., Suzuki A., Mizuno H., Shimakami Y., Kawabe T., Mase K

    UbiComp'13 

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    Event date: 2013.9

    Language:English   Presentation type:Poster presentation  

    Country:Switzerland  

  139. The effect of quercetin on the activated alveolar macrophages International conference

    Haruka Nose, Miyoko Matsushima, Aya Oomura, Kanae Mori, Nanako Ogasawara, Kazuya Takemura, Takehiro Yamaguchi, Yuka Kodera, Marika Shiga, Tsutomu Kawabe

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    Event date: 2013.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Italy  

  140. Difference in reaction patterns of M1 and M2 macrophages induced by quercetin International conference

    Miyoko Matsushima, Aya Oomura, Kanae Mori, Nanako Ogasawara, Kazuya Takemura, Haruka Nose, Takehiro Yamaguchi, Yuka Kodera, Marika Shiga, Tsutomu Kawabe

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    Event date: 2013.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Italy  

  141. Investigation on frequency of mutation in the gene segments of immunoglobulin in CD40 knockout mice International conference

    Yuka Kodera, Miyoko Matsushima, Hiroki Ogiso, Nanako Ogasawara, Kazuya Takemura, Haruka Nose, Takehiro Yamaguchi, Marika Shiga, Tsutomu Kawabe

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    Event date: 2013.8

    Language:English   Presentation type:Poster presentation  

    Country:Italy  

  142. Chrysin regulates mast cell activation via HO-1-independent pathway International conference

    Marika Shiga, Miyoko Matsushima, Ayaka Teranishi, Haruka Nose, Nanako Ogasawara, Kazuya Takemura, Takehiro Yamaguchi, Yuka Kodera, Tsutomu Kawabe

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    Event date: 2013.8

    Language:English   Presentation type:Poster presentation  

    Country:Italy  

  143. 環境物質に対するフラボノイドの細胞保護効果とその機序

    松島充代子、小笠原名奈子、武村和哉、野瀬遥加、山口剛広、小寺佑果、志賀茉梨花、上山 純、川部 勤

    第44回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神奈川   Country:Japan  

  144. Three-dimensional ultrahigh-resolution optical coherence tomography imaging of lung tissues. International conference

    Shutaro Ishida, Norihiko Nishizawa, Masashi Kitatsuji, Hiroyoshi Ohshima, Miyoko Matsushima, and Tsutomu Kawabe.

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    Event date: 2013.2

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  145. Analysis of IgE-binding epitope variation in the allergen after repeated immunization

    Yamaguchi T, Matsushima M, Nose H, Kawabe T.

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    Event date: 2012.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  146. Attenuation of Transforming Growth Factor-β-Stimulated Collagen Production in Fibroblasts by Chrysin

    Nose H, Matsushima M, Yamaguchi T, Kawabe T.

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    Event date: 2012.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  147. The Effect of Quercetin on the Activation of Alveolar Macrophages

    Matsushima M, Nose H, Yamaguchi T, Kawabe T.

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    Event date: 2012.12

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  148. 頻回な抗原の曝露によるIgE認識エピトープの解析

    山口剛広、松島充代子、川部 勤

    第62回日本アレルギー学会秋季学術大会 

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    Event date: 2012.11 - 2012.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  149. 線維化に及ぼすクリシンの効果の検討

    野瀬遥加、松島充代子、太田川茅沙、川部 勤

    第62回日本アレルギー学会秋季学術大会 

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    Event date: 2012.11 - 2012.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  150. 微細気流計を用いた喘息モデルマウスの気流変化の観察

    松島充代子、式田光宏、山本ゆき、吉川和宏、鹿野嵩瑛、川部 勤

    第62回日本アレルギー学会秋季学術大会 

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    Event date: 2012.11 - 2012.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  151. CATHETER FLOW SENSOR SYSTEM AND BREATHING MEASUREMENTS IN RABBIT International conference

    Matsuyama T, Yamazaki Y, Shikano T, Shikida M, Matsushima M, Kawabe T.

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    Event date: 2012.10

    Language:English   Presentation type:Poster presentation  

    Country:Taiwan, Province of China  

  152. INTEGRATION OF TEMPERATURE DETECTION ONTO CATHETER FLOW SENSOR FOR BRONCHOSCOPE International conference

    Yamazaki T, Yoshikawa K, Shikida M, Matsushima M, Kawabe T.

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    Event date: 2012.10

    Language:English   Presentation type:Poster presentation  

    Country:Taiwan, Province of China  

  153. 超高分解能OCTによる肺組織の3次元高解像度断層イメージング

    西澤典彦、石田周太郎、北辻真史、大島啓嘉、松島充代子、川部勤

    日本光学会年次大会Optics & Photonics Japan 2012 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  154. 膠原線維産生に及ぼすクリシンの効果についての検討

    野瀬遥加、松島充代子、太田川茅沙、川部 勤

    第7回日本臨床検査教育協議会 

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    Event date: 2012.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知   Country:Japan  

  155. IgE結合部位からみたアレルゲンの抗原性の変化

    山口剛広、松島充代子、川部 勤

    第7回日本臨床検査教育協議会 

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    Event date: 2012.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知   Country:Japan  

  156. Detection of airflow change by thermal flow microsensor in disease model rabbits International conference

    Matsushima M, Shikida M, Yamamoto Y, Shikano T, Yoshikawa K, Kawabe T.

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    Event date: 2012.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  157. 超高分解能OCTを用いた正常ならびに疾患肺の組織学的検討

    高嶋浩司、松島充代子、西澤典彦、北辻真史、大島博嘉、長谷川好規、川部 勤

    第52回日本呼吸器学会学術講演会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:兵庫   Country:Japan  

  158. TGF-beta-stimulated collagen production in fibroblasts is attenuated by quercetin-induced heme oxygenase-1

    Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Hasegawa Y, Kawabe T.

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    Event date: 2012.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  159. 肥満細胞活性化におけるクリシンの効果

    松島充代子、寺西彩香、小笠原名奈子、山本祐規子、高木 健三、川部 勤

    第132回日本薬学会 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:北海道   Country:Japan  

  160. モーションキャプチャを用いた呼吸肺気量と流速の推定

    伊藤陽脩, 榎堀 優, 川部 勤, 間瀬健二

    電子情報通信学会 総合大会(IEICE2012) 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山   Country:Japan  

  161. Estimates of Pulmonary Ventilation and Flow Using Motion Capture Device International conference

    Ito Y., Enokibori Y., Mase K., Kawabe T.

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    Event date: 2012.3

    Language:English   Presentation type:Poster presentation  

    Country:France  

  162. ケルセチンの誘導するheme oxygenase-1 によるコラーゲン産生の抑制作用

    中村俊信、松島充代子、長谷川好規、川部 勤

    第24回気道病態研究会 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  163. Ultrahigh resolution optical coherence tomography imaging of diseased rat lung using Gaussian shaped super continuum sources. International conference

    Nishizawa N., Ishida S., Kitatsuji M., Ohshima H., Hasegawa Y., Matsushima M., and Kawabe T.

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    Event date: 2012.1

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  164. MEASUREMENT OF BREATHING CHARACTERISTIC IN MOUSE DURING INHALING DRUG. International conference

    Shikano T., Shikida M., Matsushima M., Kawabe T., and Sato K.

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    Event date: 2012.1

    Language:English   Presentation type:Poster presentation  

    Country:France  

  165. 抗原に対する抗体の高親和性獲得におけるCD40の役割

    山本祐規子、松島充代子、寺西彩香、髙木健三、川部 勤

    第61回日本アレルギー学会秋季学術大会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  166. ケルセチンの抗線維化作用とHO-1の関与

    松島充代子、中村俊信、今泉和良、長谷川好規、川部 勤

    第61回日本アレルギー学会秋季学術大会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  167. クリシンの脱顆粒抑制機序の検討

    寺西彩香、松島充代子、山本祐規子、高木健三、川部 勤

    第61回日本アレルギー学会秋季学術大会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  168. Ultrahigh resolution OCT imaging of lung tissues

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  169. Analysis on the inhibitory effect of chrysin in mast cell degranulation

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  170. 気管支喘息 吸入療法 呼吸器内科医を対象とした喘息治療ステップダウンの実態調査

    伊藤理, 川部勤, 武田直也, 指尾豊和, 平松哲夫, 大林浩幸, 馬場研二, 長谷川好規

    第61回日本アレルギー学会秋季学術大会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  171. 肺組織観察用超高分解能OCTの開発と基礎的検討

    松島充代子、西澤典彦、石田周太郎、山本ゆき、北辻真史、大島啓嘉、長谷川好規、川部 勤

    第49回東海喘息研究会 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知   Country:Japan  

  172. Heme oxygease-1 induced by quercetin attenuates TGF-beta-stimulated collagen productionin fibroblasts. International conference

    Kawabe T, Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y.

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    Event date: 2011.9

    Language:English   Presentation type:Poster presentation  

    Country:Netherlands  

  173. Development of thermal flow microsensor for transbronchial measurement of local lung function International conference

    Matsushima M, Shikida M, Yamamoto Y, Yamamoto Y, Iwai S, Shikano T, Kawabe T

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    Event date: 2011.7

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  174. 脱顆粒抑制能をもつクリシンの作用機序の検討

    寺西彩香、松島充代子、森 朱美、山本祐規子、髙木健三、川部 勤

    第42回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知   Country:Japan  

  175. 肺組織観察用超分解能OCTの開発

    松島充代子、長谷川好規、川部 勤

    第23回日本アレルギー学会春季臨床大会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  176. 間質性肺炎のメカニズム 間質性肺炎におけるTh17/IL-17の関与

    小川知美, 今泉和良, 橋本直純, 橋本泉, 今井直幸, 中村俊信, 高納崇, 阪本考司, 青山大輔, 伊藤理, 佐藤光夫, 近藤征史, 長谷川好規,川部勤

    第51回日本呼吸器学会学術講演会 

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    Event date: 2011.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  177. 胸膜を介した肺組織用超分解能OCTの開発と基礎的検討

    山本祐規子、松島充代子、山本ゆき、西澤典彦、石田周太郎、北辻真史、大島啓嘉、川部 勤

    第23回気道病態研究会 

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    Event date: 2011.3

    Language:Japanese  

    Venue:東京   Country:Japan  

  178. 微細気流計を用いた経気管支的局所肺機能検査のための基礎的検討

    松島充代子、山本祐規子、山本ゆき、式田光宏、岩井 聡、川部 勤

    第23回気道病態研究会 

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    Event date: 2011.3

    Language:Japanese  

    Venue:東京   Country:Japan  

  179. クリシンの抗アレルギー作用におけるHO-1の意義.

    松島充代子,森 朱美,寺西彩香,山本祐規子,高木健三,川部 勤

    第131回日本薬学会 

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    Event date: 2011.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  180. Ultrahigh resolution optical coherence tomography imaging of lung structure using Gaussian shaped super continuum sources International conference

    Nishizawa N., Ishida S., Ohta T. Itoh K., Kitatsuji M., Ohshima H., Hasegawa Y., Matsushima M., and Kawabe T.

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    Event date: 2011.1

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  181. Ex-vivo ultra-high-resolution optical coherence tomography imaging of fine lung structure by use of a high-power Gaussian-like supercontinuum at 0.8-um wavelength International conference

    Nishizawa N., Ishida S., Ohta T. Itoh K., Kitatsuji M., Ohshima H., Hasegawa Y., Matsushima M., and Kawabe T.

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    Event date: 2011.1

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:United States  

  182. 肥満細胞のTNF-産生に対するフラボノイドの効果とHO-1の関与

    森 朱美、松島充代子、寺西彩香、山本祐規子、髙木健三、川部 勤

    第60回日本アレルギー学会秋季学術大会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  183. Ultrahigh resolution optical coherence tomography imaging of lung tissue using Gaussian shaped super continuum sources

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    Event date: 2010.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  184. クリシンの抗アレルギー作用とHO-1の関与

    寺西彩香、松島充代子、森 朱美、山本祐規子、髙木健三、川部 勤

    第60回日本アレルギー学会秋季学術大会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  185. IgEの結合部位からみたアレルギーの病態解明

    松島充代子、川部 勤

    第47回東海喘息研究会 

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    Event date: 2010.9

    Language:Japanese  

    Venue:愛知   Country:Japan  

  186. ペプチドアレイへのIgE/IgG4の結合パターンによるミルクアレルギー診断

    片山真、加藤竜司、大河内美奈、本多裕之、川部勤、松島充代子、川瀬三雄、吉田安子、高瀬智和

    化学工学会第42回秋季大会 

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    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  187. Structure-activity relationship of flavonoids for anti-allergic effects and the induction of heme oxygenase-1 in RBL-2H3 cells International conference

    MATSUSHIMA Miyoko, HIRAYAMA Tatsuya, MORI Akemi, KAWABE Tsutomu

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    Event date: 2010.8

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  188. Structure-activity relationship of flavonoids for anti-allergic effects and the induction of heme oxygenase-1 in RBL-2H3 cells International conference

    MATSUSHIMA Miyoko, HIRAYAMA Tatsuya, MORI Akemi, KAWABE Tsutomu

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    Event date: 2010.8

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  189. フラボノイドの抗アレルギー作用およびHO-1の発現誘導を決定する構造の探索

    松島充代子、髙木健三、森 朱美、寺西彩香、山本祐規子、川部 勤

    第41回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:群馬   Country:Japan  

  190. Implantable flow sensor into airway for laboratory animal

    MATSUNAGA Naoyuki., YOKOTA Takuo., SHIKIDA Mitsuhiro., KAWABE Tsutomu., MATSUSHIMA Miyoko., IWAI Satoshi., SATO Kazuo

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    Event date: 2010.7

    Language:English   Presentation type:Poster presentation  

    Country:Australia  

  191. フラボノイドのHO-1を介した抗アレルギー作用とC環2重結合の意義

    森 朱美、松島充代子、寺西彩香、山本祐規子、髙木健三、川部 勤

    第6回日本食品免疫学会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  192. フラボノイドによるHO-1を介した抗アレルギー作用とその構造

    森 朱美、川部 勤、松島充代子、平山達也、高木健三

    第22回日本アレルギー学会春季臨床大会 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  193. 0.8um 帯超高分解能OCT を用いた高解像度肺組織イメージング

    西澤典彦、石田周太郎、太田健史、伊東一良、北辻真史、大島啓嘉、松島充代子、川部 勤

    第57回応用物理学関係連合講演会 

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    Event date: 2010.3

    Language:Japanese  

    Venue:神奈川   Country:Japan  

  194. HO-1を介したフラボノイドの抗アレルギー活性と構造活性相関

    森 朱美、川部 勤、松島充代子、平山達也、高木健三

    第22回気道病態研究会 

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    Event date: 2010.2

    Language:Japanese  

    Venue:東京   Country:Japan  

  195. Structure-activity relationship of flavonoids for anti-allergic effects by induced heme oxygenase-1

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    Event date: 2009.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  196. Ghrelin and Obestatin Activate Rat Peritoneal Mast Cells as Basic Secretagogues

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    Event date: 2009.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  197. 動物実験用気道埋め込み型流量センサの開発

    岩井 聡、松永直之、横田拓央、式田光宏、川部 勤、松島充代子、佐藤一雄

    電気学会センサ・マイクロマシン部門主催 第26回「センサ・マイクロマシンと応用システム」シンポジウム 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  198. フラボノイドの構造によるHO-1発現誘導能の差と抗アレルギー作用の検討

    松島充代子、川部 勤、平山達也、森 朱美、高木健三

    第59回日本アレルギー学会秋季学術大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:秋田   Country:Japan  

  199. グレリンおよびオベスタチンによる肥満細胞活性化機序の検討

    平山 達也、川部 勤、松島充代子、森 朱美、高木健三

    第59回日本アレルギー学会秋季学術大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:秋田   Country:Japan  

  200. 構造によるフラボノイドの抗アレルギー作用の検討

    平山達也、川部 勤、松島充代子、森 朱美、高木健三

    第40回日本職業・環境アレルギー学会総会 

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    Event date: 2009.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知   Country:Japan  

  201. Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells

    MATSUSHIMA Miyoko., KAWABE Tsutomu, HIRAYAMA Tatsuya., MORI Akemi., TAKAGI Kenzo.

    19th Congress of Interasma Japan North Asia 

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    Event date: 2009.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  202. 牛乳アレルゲン由来の30種ペプチドアレイ開発の試み

    松本直樹、松島充代子、伊藤浩明、坂本龍雄、川部 勤

    第21回日本アレルギー学会春季臨床大会 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  203. Myricetin involved heme oxygenase-1 in its anti-allergic actions.

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    Event date: 2008.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  204. 構造によるフラボノイドの抗アレルギー作用の検討

    太田裕以、川部 勤、松島充代子、平山達也、高木健三

    第58回日本アレルギー学会総会 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  205. ミルクアレルギー患者のIgE認識エピトープの高集密ペプチドアレイによる検討

    川部 勤、松島充代子、松本直樹、伊藤浩明、坂本龍雄

    第58回日本アレルギー学会総会 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  206. グレリンによる肥満細胞活性化機序の検討

    平山達也、川部 勤、松島充代子、太田裕以、高木健三.

    第58回日本アレルギー学会総会 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  207. ミルクアレルギー診断のための高集密ペプチドアレイの作製と解析

    本多裕之、加藤竜司、竹下敏一、大河内美奈、川部 勤、松島充代子、松本 直樹、坂本龍雄、廣瀬悦子、川瀬三雄、吉田 安子、高瀬 智和、小川 昭子

    化学工学会第40回秋季大会 

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    Event date: 2008.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮城   Country:Japan  

  208. ケンフェロールの抗アレルギー活性発現におけるHO-1の役割

    太田裕以、川部 勤、松島充代子、廣瀬悦子、平山達也、高木健三

    第39回日本職業・環境アレルギー学会 

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    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  209. ミリセチンの抗アレルギー作用機序の検討

    太田裕以、川部 勤、松島充代子、平山達也、高木健三

    第20回日本アレルギー学会春季臨床大会 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  210. heme oxygenase(HO)-1誘導を介したミリセチンによる脱顆粒の抑制

    太田裕以、川部 勤、松島充代子、廣瀬悦子、高木健三

    第128回日本薬学会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  211. 肥満細胞におけるケルセチンの抗アレルギー作用機序の検討

    松島充代子、川部 勤、廣瀬悦子、太田裕以、平山達也、高木健三.

    第128回日本薬学会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  212. ケンフェロールの抗アレルギー作用におけるHeme oxygenase (HO)-1の役割

    廣瀬悦子、川部 勤、松島充代子、松本直樹、太田裕以、高木健三

    第57回日本アレルギー学会総会 

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    Event date: 2007.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  213. Anti-allergic actions of quercetin are mediated by heme oxygenase-1 in RBL-2H3 cells

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    Event date: 2007.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  214. 肥満細胞におけるケルセチンのHO-1活性化制御の検討

    太田裕以、川部 勤、松島充代子、松本直樹、廣瀬悦子、高木健三

    第57回日本アレルギー学会総会 

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    Event date: 2007.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  215. ケルセチンの抗アレルギー作用におけるheme oxygenase (HO)-1の役割

    松島充代子、川部 勤、小川三由紀、廣瀬悦子、古部裕子、太田裕以、安部文江、高木健三

    第19回日本アレルギー学会春季臨床大会 

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    Event date: 2007.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  216. 肥満細胞におけるケンフェロールの抗アレルギー作用の検討

    小川三由紀,川部 勤,松島充代子,安部文江, 長谷川高明,高木健三

    第56回日本アレルギー学会総会 

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    Event date: 2006.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  217. フラボノイドの生体における抗アレルギー作用の検討

    松島充代子, 川部 勤, 小川三由紀,安部文江,長谷川高明, 高木健三

    第18回日本アレルギー学会春季臨床大会 

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    Event date: 2006.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  218. アトピー素因および吸入感作による抗原特異的IgE産生抑制に関する原因遺伝子の検討

    岡本真和、川部 勤、原 徹、伊藤 康、今泉和良、久米裕明、長谷川好規、高木健三、下方 薫

    第55回日本アレルギー学会秋季学術大会 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岩手   Country:Japan  

  219. 肥満細胞におけるフラボノイドの抗アレルギー作用の検討

    松島充代子、川部 勤、小川三由紀、安部文江、長谷川高明、高木健三

    第55回日本アレルギー学会秋季学術大会 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岩手   Country:Japan  

  220. 肥満細胞におけるフラボノイドの抗アレルギー作用の検討

    松島充代子, 川部 勤, 小川三由紀,安部文江,長谷川高明, 高木健三

    第55回日本アレルギー学会総会 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岩手   Country:Japan  

  221. マウス喘息モデルでの疾患感受性遺伝子の検索シンポジウム2 「アレルギー疾患発症に関わる環境因子と遺伝因子」

    川部 勤 岡本真和

    第36回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2005.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:愛知   Country:Japan  

  222. 健康補助食品が肥満細胞の脱顆粒に及ぼす影響

    松島充代子、川部 勤、小川三由紀、安部文江、長谷川高明、高木健三

    第36回日本職業・環境アレルギー学会総会・学術大会 

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    Event date: 2005.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  223. マウス喘息モデルでの疾患感受性遺伝子の検索

    岡本真和、川部 勤、原 徹、伊藤 康、今泉和良、久米裕明、長谷川好規、高木健三、下方 薫

    第16回日本アレルギー学会春季臨床大会 

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    Event date: 2005.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  224. Quantitative Trait Loci Analysis on Allergic Asthma in SMXA RI and Consomic Mice International conference

    Okamoto M, Kawabe T, Hara T, Hashimoto N, Imaizumi K, Hasegawa Y, Ohno T, Nishimura M, Shimokata K

    ATS 2005 San Diego, International Conference, American Thoracic Society 100 Anniversary 

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    Event date: 2005.5

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  225. Mini-Symposium, Evaluation of Th1-Type Cytokines and Chemokines as Diagnostic Markers of Tuberculous Pleural Effusions. International conference

    Kawabe T, Okamoto M, Hara T, Hashimoto N, Imaizumi K, Hasegawa Y, Takagi K, Shimokata K

    ATS 2005 San Diego, International Conference, American Thoracic Society 100 Anniversary 

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    Event date: 2005.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  226. Th1/Th2 Chemokine Expression in Non-Small Cell Lung Cancer Tissue: Increased Expression of CCL22 (MDC) May Be Associated with Better Prognosis International conference

    Imaizumi K, Nakanishi T, Kawabe T, Okamoto M, Ito G, Hashimoto N, Sumida A, Kojima K, Sekido Y, Ito Y, Kume H, Hasegawa Y, Shimokata K

    ATS 2005 San Diego, International Conference, American Thoracic Society 100 Anniversary 

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    Event date: 2005.5

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  227. 肺線維症の病態形成における骨髄由来細胞の関与

    橋本直純、川部 勤、今泉和良、長谷川好規、下方 薫

    第9回Acute Lung Injury研究会 

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    Event date: 2005.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  228. 肥満細胞におけるフラボノイドの抗アレルギー作用の検討

    松島充代子、川部 勤、青山真梨子、田中成一、長谷川高明、高木健三

    第17回気道病態シンポジウム 

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    Event date: 2005.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  229. 結核性及び癌性胸膜炎におけるサイトカイン

    岡本真和、川部 勤、原 徹、伊藤 康、今泉和良、久米裕明、長谷川好規、高木健三、下方 薫

    第54回日本アレルギー学会総会 

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    Event date: 2004.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  230. SMXAリコンビナント近交系マウスを用いた気管支喘息の原因遺伝子の同定と解析

    岡本真和、川部 勤、原 徹、伊藤 康、今泉和良、久米裕明、長谷川好規、高木健三、下方 薫

    第16回日本アレルギー学会春季臨床大会 

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    Event date: 2004.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  231. 結核性胸膜炎におけるサイトカインの動態

    岡本真和、川部 勤、原 徹、伊藤 康、今泉和良、久米裕明、長谷川好規、高木健三、下方 薫

    第74回実験結核研究会 

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    Event date: 2004.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  232. ヒト気道上皮細胞におけるCa2+依存性K+チャネルを介した細胞外ATP受容体刺激のメカニズム

    伊藤 康、孫 政実、佐藤慎二、石川貴之、近藤征史、川部 勤、今泉和良、長谷川好規、下方 薫

    第44回日本呼吸器学会学術講演会 

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    Event date: 2004.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  233. 肺癌組織および肺癌細胞株におけるTh1細胞遊走性ケモカイン発現の解析

    中西 亨、今泉和良、川部 勤、岡本真和、伊藤源士、住田 篤、小島克之、伊藤 康、久米裕明、関戸好孝、長谷川好規、下方 薫

    第44回日本呼吸器学会学術講演会 

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    Event date: 2004.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  234. SMXAリコンビナント近交系マウスを用いたアレルギー遺伝子の同定と解析

    岡本真和、川部 勤、長谷川好規、大野民生、西村正彦、高木健三

    第16回気道病態シンポジウム 

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    Event date: 2004.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  235. Involvement of lipid rafts on Nrf2 activation induced by quercetin

    Matsushima Miyoko, Nose Haruka, Kusatsugu Yuto, Atsumi Kazuko, Sasou Kanako, Tanaka Kyohka, Sugiyama Tomoshi, Ohdachi Tomoko, Hashimoto Naozumi, Kawabe Tsutomu

    Proceedings for Annual Meeting of The Japanese Pharmacological Society  2018  Japanese Pharmacological Society

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    Language:English   Presentation type:Poster presentation  

    <p>Quercetin is one of the flavonoids and has a wide variety of cytoprotective effects. We previously reported that quercetin exerted various cytoprotective effects via nuclear factor E2-related factor 2 (Nrf2)-heme oxygenase (HO)-1 pathway. However, the mechanisms how quercetin can induce HO-1 to exhibit cytoprotective effects are poorly understood. We focused on cell membrane, which is the front line to interact with extracellular environment and plays an important role in cellular signaling. Recent studies showed that Nrf2 interacted with caveolin-1 (Cav-1), a component of caveolae, to regulate cellular anti-oxidant capacity. In this study, we investigated the involvement of Cav-1 in quercetin-induced HO-1 expression. We showed that quercetin changed the formation of lipid rafts, and the expression level of Cav-1 was decreased in cell membrane and increased in cytosol and nucleus after exposure to quercetin. The expression level of Nrf2 localized in cell membrane was also decreased, and Nrf2 was translocated to cytosol and nucleus. The extent of HO-1 induction by quercetin was as much as that by methyl-beta-cyclodextrin, a cholesterol-depleting agent. These findings suggested that HO-1-dependent cytoprotective effects by quercetin could be mediated through the disruption of lipid rafts, leading Cav-1 and Nrf2 to translocate from cell membrane and to nucleus, followed by HO-1 induction.</p>

    DOI: 10.1254/jpssuppl.wcp2018.0_po4-8-38

    CiNii Research

  236. MEMS Flow Sensor Capable of Measuring Multi-Vital Signs of Respiration, Heart Rate, and Body Temperature International conference

    Hasegawa Y., Lee S., Matsushima M., Hasegawa S., Kawabe T., Shikida M.

    21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021  2021.6.20  21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021

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    Language:English   Presentation type:Poster presentation  

    Multi-vital signs detection; respiration, heart rate, and body temperature from respiration airflow at the mouth was proposed, and three sensors patterns (flow-rate, - direction, and -temperature sensors) were formed on a single MEMS sensor. The small-sized tube type flow sensor was designed and fabricated to apply it the animal experiment, and its detection characteristics were experimentally evaluated. The flow rate sensor output followed the King's equation, and the response time of 50 ms was obtained to confirm the following oscillating breathing airflow measurement. Then, we confirmed that the fabricated sensor can measure the airflow whose temperature changes periodically. Finally, we conducted an animal experiment using rats, and confirmed that the fabricated sensor can measure three vital signs of respiration, heart rate, and body temperature from respiration.

    DOI: 10.1109/Transducers50396.2021.9495387

    Scopus

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Research Project for Joint Research, Competitive Funding, etc. 12

  1. 呼吸情報に基づいたマルチバイタルサイン計測技術の研究開発

    2018.4 - 2021.3

    戦略的基盤技術高度化支援事業 

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    Grant type:Competitive

  2. 高親水性表層を有する多層型薬物用吸着剤の開発と呼気中薬物モニタリングへの応用

    2015.4 - 2017.3

    科学技術交流財団・共同研究推進事業 

    山本 敦

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    Grant type:Competitive

  3. 肺内部でのその場計測を可能にするカテーテルセンサの開発

    2014.4 - 2016.3

    キャノン財団 

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    Grant type:Competitive

  4. 動物用生体埋め込み型気流センサの開発

    2012.4 - 2014.3

    特色ある大学教育支援プログラム 

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    Grant type:Competitive

  5. 超早期診断技術開発プロジェクト

    2011.4 - 2016.3

    愛知県「知の拠点」重点研究プロジェクト 

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    Grant type:Competitive

  6. フラボノイドによる急性肺障害治療法の開発

    2009.4 - 2010.3

    那古野医学振興会  

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    Grant type:Competitive

  7. スーパーコンティニューム光源を用いた胸膜を介した肺組織用超高分解能OCTの研究

    2008.4 - 2013.3

  8. 先端融合領域イノベーション創出拠点の形成 分析・診断医工学による予防早期医療の創成

    2006.4 - 2009.3

    特色ある大学教育支援プログラム 

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    Grant type:Competitive

  9. 間質性肺炎発症機序における肺胞マクロファージの免疫抑制機能の分子的検討

    2005.4 - 2006.3

    那古野医学振興会 

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    Grant type:Competitive

  10. 間質性肺炎発症機序における肺胞マクロファージの免疫抑制機能の分子的検討

    2005 - 2006

    名古屋大学学術振興基金 

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    Grant type:Competitive

  11. Evaluation of Th1-Type Cytokines and Chemokines as Diagnostic Markers of Tuberculosis Pleural Effusions

    2005

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    Grant type:Competitive

  12. 遅発型炎症反応での肥満細胞の免疫応答調節

    2004

    那古野医学振興会 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 19

  1. ストレスセンシング機構を標的としたフラボノイドの細胞保護作用発動機構の解明

    Grant number:20K11529  2020.4 - 2023.3

    松島 充代子

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    Authorship:Coinvestigator(s) 

    フラボノイドは天然の機能性成分で、多彩な細胞保護効果を示す。本研究ではフラボノイドは共通した起点となる細胞膜でセンシングされ、普遍的な生体防御機構を誘導すると考え、細胞がフラボノイドを感知するストレスセンシング機構を探索・同定し、フラボノイドの多彩な細胞保護効果の発揮の出発点となる分子機構を解明する。

  2. マクロファージを主軸とする自然免疫応答から探求する傷害組織の修復機構の解明

    Grant number:20K07824  2020.4 - 2023.3

    川部 勤

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    マクロファージの組織の修復機転、特に死細胞を貪食処理するエフェロサイトーシスに自然免疫の環境がどのような意義を持つのか、マクロファージの他、修復機構に重要な働きをすると考えられる、傷害部位の組織構成細胞や自然リンパ球がどのように協働しているかを解明する。本研究により解明される有効な修復機構を誘導することで、組織傷害に対してより完全な修復・治癒機転の招来をもたらす。

  3. Development of analytical methods of exhaled breath condensate analysis and their application to diagnosis of respiratory disease

    Grant number:19H02751  2019.4 - 2022.3

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    Authorship:Coinvestigator(s) 

  4. 末梢気道での呼吸計測を可能にする局所的肺機能計測システム技術の開発

    Grant number:18K04912  2018.4 - 2021.3

    長谷川 義大

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    Authorship:Coinvestigator(s) 

    本研究では,現代医学で未解明なる領域とされている末梢気道での呼気吸気メカニズムを解明することを目的とし,末梢気道での呼吸を定量的に計測評価できる「局所的肺機能計測システム技術」の実現を目指した.具体的には,今年度は,各種医療用ツールとのタンデム仕様が可能な外壁実装型チューブ状流量センサの開発を中心に,以下の研究課題に取り組んだ.
    ①医療用ツールとのタンデム使用が可能な外壁実装型チューブ状流量センサの開発:(1)H30年度に開発した呼吸計測用の流量センサの作製プロセスを一部改良し,センサ作製の歩留まりおよび信頼性を向上させた.具体的には,流量センサ素子の配線を一部共通化し,また配線間隔を見直した.作製したセンサの流量特性評価の結果,ヒトの呼吸周期(3.3s)に対して十分な応答性(20.2 ms)を得た.また,センサを設置する管の内径に依存しない流速とセンサ出力の関係を取得した.(2)医療用ツールと外壁実装型チューブ状流量センサとのタンデム化:R01年度は気管支流体抵抗の取得を目指し,圧力センサとのタンデム化を検討した.具体的には,市販のMEMS圧力センサチップ(2.5 mm角)を幅2.0 mmの樹脂板上に実装することで,気道内に挿入可能な圧力センサプローブを作製した.
    ②気管支へのセンサ挿入検討および動物実験による検証:動物実験の実施に先立ち,R01年度は模擬肺であるフローボリュームシミュレータを用いて,作製した流量センサおよび圧力センサプローブの流量および圧力計測機能を検証した.模擬肺から伸ばした計測用チューブに流量センサおよび圧力センサを挿入し,ヒトの呼吸を模擬した流量波形(例えば,一回換気量2.0 L,周波数0.2 Hz)を流し,流量と圧力の関係の取得が可能であることを確認した.今後データ解析を進め,気管支流体抵抗の取得法を確立し,動物実験を実施する予定である.
    交付申請書記載の研究計画に従い,本年度は,①医療用ツールとのタンデム使用が可能な外壁実装型チューブ状流量センサの開発,②気管支へのセンサ挿入検討および動物実験による検証の二つの研究課題に取り組んだ結果,①に関しては,昨年度開発した流量センサ素子の改良を行い,信頼性および生産性の向上を果たした.そして作製した流量センサは,ヒトの呼吸周期に対して十分な応答性および流量計測機能を有することを確認した.更に新たなセンサデバイスとして,圧力センサプローブの開発(市販の圧力センサ素子を気道内に挿入可能なプローブ状に実装)を行った.②に関しては,作製した流量センサおよび圧力センサプローブを動物実験の事前検討として,模擬肺を用いて人の呼吸を模擬した流量波形により評価した.その結果,管内流れの流量および圧力の波形を得ることができた.これらの結果より,研究はおおむね順調に進展していると判断した.
    今後については,当初の予定通り,以下の研究課題に取り組む予定である.
    ①医療用ツールとのタンデム使用が可能な外壁実装型チューブ状流量センサの開発:本テーマでは,これまでに開発した流量センサおよび圧力センサプローブの改良に取り組む.また,新たなセンサ(ガス,超音波など)とのタンデム化の検証を行う.具体的には,気道内局所部における酸素,二酸化炭素濃度を明らかにできるガスセンサとのタンデム化が可能か検証する予定である.
    ②気管支へのセンサ挿入検討および動物実験による検証
    R01年度に検証した流量および圧力センサから得られた情報から,気管支流体抵抗の取得法の確立に取り組む.また,作製した圧力センサプローブをラビットなどの動物の気道内に挿入し,実際の動物における流量圧力波形の計測機能を検証する.それらの結果を①へフィードバックする.これらから,局所的な肺機能計測システムの実現を目指す.

  5. Analysis of adverse effects of acetylcholinergic pesticides focused on the induction of host defense reaction and immune disruption

    Grant number:17K00547  2017.4 - 2020.3

    Kawabe Tsutomu

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    In this study, we investigated the effects of acetylcholinergic pestcides, particularly neonicotinoid pesticides, on the induction of host defense reaction and functions of macrophages and T cells. We showed that acetamiprid modulated the function of alveolar macrophages. Briefly, acetamiprid inhibited the levels of inflammatory cytokine mRNA expression and phagocytosis induced by imiquimod, a ligand of TLR7, in alveolar macrophages, while acetamiprid exhibited little effect on the induction of host defense reaction including HO-1 expression and autophagy. Moreover, acetamiprid did not affect T-cell activation. These results suggested the possibility that acetamiprid could influence the host defense reaction in the lung.

  6. The role of cell membrane in cytoprotective effects of flavonoids

    Grant number:15K08228  2015.4 - 2018.3

    Matsushima Miyoko

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    Authorship:Coinvestigator(s) 

    Flavonoids, which are contained in fruit and vegetables, exhibit wide variety of cytoprotective effects. We previously reported that quercetin exerted various cytoprotective effects via nuclear factor E2-related factor 2 (Nrf2)-heme oxygenase (HO)-1 pathway. In this study, we focused on cell membrane, which is the first line to interact with extracellular environment and plays an important role in cellular signaling, and investigated the involvement of cell membrane changes in quercetin-induced cytoprotective effects. We showed that quercetin changed the formation of lipid rafts by depleting cholesterol from cell membrane. The expression levels of caveolin-1 and Nrf2 localized in cell membrane were also decreased, and caveolin-1-Nrf2 complex was translocated to cytosol and nucleus. These findings suggested that translocation of caveolin-1-Nrf2 complex to nucleus might lead the induction of HO-1.

  7. Study on non-invasive assessment of pharmacokinetics by exhaled breath

    Grant number:15K07903  2015.4 - 2018.3

    YAMAMOTO Atsushi

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    Authorship:Coinvestigator(s) 

    The method was established to collect the drug in exhaled breath of rat administered theophylline. The rat expiratory volume per time was uncertain, however, the search of endogenous biomarkers for the expiratory volume was left as a pending problem.
    The analysis of fexofenadine, an antihistamine pharmaceutical drug, in human breath and blood could not meet good correlation. There was no tendency for the determined amount of fexofenadine in breath to decrease with the elapsed time. The existence of the blood-lung interface was suggested. Although the exhaled breath condensate was used for breath analysis, there was a tendency for low collection rate of the breath aerosol. The filter sampling method for the aerosol would be desired.

  8. MEMS sensor based in-situ measurements systems for detecting breathing and optical surface image characteristics at small airways

    Grant number:26286034  2014.4 - 2018.3

    Shikida Mitsuhiro

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    Authorship:Coinvestigator(s) 

    MEMS technologies were applied for producing the in-situ measurement system that could be used to detect both breathing and optical surface image properties at the small airways. The response time value of the flow sensor was shortened to less than 52 ms by decreasing the thermal capacity of around the heater. Then the thermal flow sensor was integrated onto a basket forceps to fix the flow sensor onto the inside surface of the airway. The basket-forceps-type flow sensor was applied in an animal experiment in which it successfully detected the breathing properties in the airway of a rat. Finally, the tube flow sensor was developed to be easily attached to an optical fiberscope. The fabricated tube flow sensor was attached to the outside of a fiberscope with 1.6 mm in diameter, and it was inserted into a tube that was connected to the airway of a rat. An optical image in the tube was captured, and its breathing airflow rate was successfully detected.

  9. 肺内部での吸気呼気計測を可能にする超小型カテーテル流量センサの開発

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(B)

  10. 間葉系幹細胞の多分化能と免疫寛容を有効利用する再生基礎研究 

    2010.4 - 2014.3

    科学研究費補助金  基盤研究(B)

    鳥橋茂子

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    Authorship:Coinvestigator(s) 

  11. Development of electric stimulation to inhibit post-operative hyper catabolism of skeletal muscles

    Grant number:22300186  2010 - 2012

    YAMADA Sumio

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    Authorship:Coinvestigator(s) 

    [Study 1] We investigated skeletal muscle proteolysis and postoperative muscle weakness immediately after cardiovascular surgery(CVS) based on 24 hour urinary 3-methylhistidine/Creatinine(24h-u3MH/Cre). [Methods]Thirty seven patients underwent CVS were enrolled. Iterleukin-6(IL-6) production, cortisol, growth hormone(GH), IGF-1, BCAA, AAA, respiratory muscle power, grasp strength, knee extension strength and 24h-u3MH were measured. [Results]IL-6 and cortisol increased immediately after the CVS and IGF-1/GH and BCAA/AAA decreased, showing postoperative hypercatabolism. 24h-u3MH/Cre successively increased and peak out at 4th postoperative day and cumulative value during 5 days significantly correlated with IL-6 production and the magnitude of decrease in knee extension muscle strength. [Conclusions] Hyper-catabolism due to CVS correlates with postsurgical muscle proteolysis and muscle weakness.[Study 2] We investigated the feasibility of electrical stimulation (ES) intervention and the preventive effect of ES on postoperative muscle proteolysis in patients immediately after cardiovascular surgery by nonrandomized controlled trial.-Feasibility study; Sixty eight patients were consecutively recruited to the study from November 2011. Patients received ES from postoperative day (POD) 1 for 2 weeks and we found no clinical adverse event and they cleared criteria for success of feasibility.-Nonrandomized controlled trial; We compared 32 patients who received ES group with 32 patients who didn’t by group matching based on obesity and IL-6 immediate after surgery. The values of 3MH/Cre on POD4 and POD5 adjusted by that of POD1 were significantly low in ES group. We also found little reduction (

  12. Heme oxygenase-1 mediates the anti-allergic actions of flavonoids in mast cells

    Grant number:19590554  2007 - 2008

    TAKAGI Kenzo

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    Authorship:Coinvestigator(s) 

  13. Verifications the care to establish the breath at birth in well-being infants

    Grant number:19791649  2007 - 2008

    TAKAHASHI Yuki

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    Authorship:Other 

  14. マウス・コンソミック系統群に見出された統合的致死現象の原因遺伝子の解析

    Grant number:19650105  2007 - 2008

    萌芽研究

    大野 民生

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    Authorship:Coinvestigator(s) 

    コンソミック系統(A/J-7A^<SM>)の妊娠雌を帝王切開して得た産仔の詳細な観察を行った結果、D7Mit125-D7Mit355の領域がSM/J系統のホモ型となっている個体は一切蘇生しなかったが、その領域がA/J系統とSM/J系統のヘテロ型やA/J系統のホモ型となっている個体はともに約70%の個体が蘇生した。したがって、死亡原因は呼吸障害によると考えられたが、当該領域がSM/J系統のホモ型となっている個体の肺の組織学的な観察では、明確な異常が認められなかったため、呼吸障害は肺の異常以外に呼吸中枢の異常による可能性も推定された。A/J系統とSM/J系統を起源として樹立された23系統のSMXAリコンビナント近交系群のSDP(Strain Distribution Pattern)を構成するマーカー数を増やしてより詳細なSDPを構築し、Chr.7の中央部のSM/J系統由来の領域と相互作用して致死現象を起こすA/J系統由来の遺伝子の存在領域を再検証したが、目的とする領域はなかった。したがって、SM/J系統のChr.7の中央部に存在する遺伝子とA/J系統由来の遺伝子が相互作用して致死に至るのではなく、コンソミック系統作製の過程でSM/J系統のChr.7の中央部に存在する遺伝子に起きた変異が致死現象の原因と考え、D7Mit125-D7Mit355の領域内に存在する遺伝子から欠損マウスが致死となることが知られているIlk遺伝子について塩基配列と遺伝子発現を調べたが全く異常がなかった。次に、機能が不明であるが肺で強発現することが知られているDchs1遺伝子の発現を解析したところ、当該領域がSM/J系統のホモ型となっている個体ではこの遺伝子がほとんど発現していないことが判明し、この遺伝子に起きた何らかの変異がA/J-7A^<SM>系統の致死を起こしていると推定された。

  15. 先端融合領域イノベーション創出拠点の形成、分析・診断医工学による予防早期医療の創成

    2006.4 - 2009.3

    科学研究費補助金  科学技術振興調整費

    2006-2008 平野眞一、2009 濵口道成

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    Authorship:Coinvestigator(s) 

  16. 気管支喘息の遺伝子治療のための基礎的研究

    2006 - 2007

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  17. 肺癌治療における薬物トランスポーター遺伝子多型の研究

    2005 - 2006

    科学研究費補助金  基盤研究(C)

    長谷川 好規

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    Authorship:Coinvestigator(s) 

  18. 遺伝子欠損マウスを用いた閉塞性細気管支炎の病態研究

    2002.4 - 2004.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  19. SMXAリコンビナント近交系マウスを用いたアレルギー遺伝子の同定と解析

    2000.4 - 2002.3

    科学研究費補助金  特定領域研究(C) ゲノム医科学

    長谷川好規

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    Authorship:Coinvestigator(s) 

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Industrial property rights 9

  1. 呼気ミスト捕集装置、呼気ミスト分析システム、呼気ミスト捕集方法及び呼気ミスト分析方法

    松島 充代子 加藤 祐史 東海林 秀典 山本 敦 山本 良平

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    Application no:2017-099147  Date applied:2017.5

    Announcement no:2018-194463  Date announced:2018.12

    Country of applicant:Domestic  

  2. 医療用流れ測定装置およびその製造方法

    川部 勤 松島 充代子 式田 光宏 長谷川 義大

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    Application no:2016-212332  Date applied:2016.10

    Announcement no:2018-068667  Date announced:2018.5

    Country of applicant:Domestic  

  3. 心拍信号検出装置

    川部 勤,式田光宏,松島充代子

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    Application no:2016-573411  Date applied:2016.2

    Patent/Registration no:第6399614号  Date registered:2018.9 

    Country of applicant:Domestic  

  4. 気管内挿管チューブ装着器具及びその製造方法

    式田光宏,川部 勤,松島充代子

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    Application no:2013-003749  Date applied:2013.1

    Patent/Registration no:第6265363号  Date registered:2018.1 

    Country of applicant:Domestic  

  5. 呼吸計測方法および呼吸計測装置

    榎堀 優, 間瀬健二, 川部 勤, 池田幸治, 鈴木陽久, 水野寛隆, 池口達治, 堀場隆広, 島上祐樹

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    Application no:2012-130773  Date applied:2012.6

    Announcement no:2009-16848 

    Patent/Registration no:第5838447号  Date registered:2015.11 

    Country of applicant:Domestic  

  6. 生体埋め込み型流量センサ

    式田光宏,川部 勤,松島 充代子, 横田拓央, 岩井 聡, 松永 直之

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    Application no:2011-536071  Date applied:2010.8

    Announcement no:2009-16848 

    Patent/Registration no:第5626689号  Date registered:2014.10 

    Country of applicant:Domestic  

  7. アレルギー疾患を診断するための方法

    本多裕之, 大河内美奈, 加藤竜司, 松本直樹, 川部 勤, 松島充代子, 吉田安子, 高瀬智和

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    Application no:2011-506158  Date applied:2010.3

    Patent/Registration no:第5728678号  Date registered:2015.4 

    Country of applicant:Domestic  

  8. アレルゲンのエピトープ又はその候補の検出方法及びその利用

    本多裕之, 大河内美奈, 加藤竜司, 松本直樹, 川部 勤, 松島充代子, 吉田安子, 高瀬智和

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    Application no:2010-536707  Date applied:2009.11

    Announcement no:2009-168480 

    Patent/Registration no:第5737673号  Date registered:2013.2 

    Country of applicant:Domestic  

  9. 流量センサ

    式田光宏,川部 勤,内藤淳平,林 悠太,横田拓央

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    Application no:2008-3830  Date applied:2008.1

    Announcement no:2009-168480 

    Patent/Registration no:第5149018号  Date registered:2013.2 

    Country of applicant:Domestic  

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Teaching Experience (On-campus) 133

  1. Immunology

    2021

  2. Laboratory Immunology II

    2021

  3. First Year Seminar A

    2020

  4. Immunology

    2020

  5. 検査技術科学特論Ⅳ(病因系)

    2020

  6. 病因検査技術開発法Ⅱ

    2020

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  7. 免疫検査学実習A

    2020

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  8. Clinical Immunology II

    2020

  9. 生体防御学

    2020

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  10. Clinical Immunology I

    2020

  11. 病因病態解析学特論

    2020

  12. 医療英語

    2020

  13. 臨床病態解析学概論

    2020

  14. 病因検査技術開発法Ⅱ

    2019

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  15. Clinical Immunology I

    2019

  16. First Year Seminar A

    2019

  17. Immunology

    2019

  18. 検査技術科学特論Ⅳ(病因系)

    2019

  19. 免疫検査学実習A

    2019

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  20. Clinical Immunology II

    2019

  21. 生体防御学

    2019

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  22. 病因病態解析学特論

    2019

  23. 生物学基礎II

    2019

  24. 医療英語

    2019

  25. 臨床病態解析学概論

    2019

  26. 検査技術科学特論Ⅳ(病因系)

    2018

  27. Immunology

    2018

  28. Clinical Immunology I

    2018

  29. First Year Seminar A

    2018

  30. 免疫学実習

    2018

     詳細を見る

    免疫学実験の最も基礎である免疫操作法,採血法,血清の分離法,免疫細胞の調製法を修
    得する。さらに血清を用いた赤血球凝集反応,マウスを用いたアナフィラキシー反応と移植
    免疫実験を行う。

  31. 免疫検査学実習A

    2018

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  32. Clinical Immunology II

    2018

  33. 生体防御学

    2018

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  34. 病因検査技術開発法Ⅱ

    2018

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  35. 病因病態解析学特論

    2018

  36. 医療英語

    2018

  37. 臨床病態解析学概論

    2018

  38. Immunology

    2017

  39. Clinical Immunology I

    2017

  40. 免疫学実習

    2017

     詳細を見る

    免疫学実験の最も基礎である免疫操作法,採血法,血清の分離法,免疫細胞の調製法を修
    得する。さらに血清を用いた赤血球凝集反応,マウスを用いたアナフィラキシー反応と移植
    免疫実験を行う。

  41. 免疫検査学実習A

    2017

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  42. Clinical Immunology II

    2017

  43. 生体防御学

    2017

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  44. 検査技術科学特論Ⅳ(病因系)

    2017

  45. 病因検査技術開発法Ⅱ

    2017

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  46. 病因病態解析学特論

    2017

  47. 臨床病態解析学概論

    2017

  48. Immunology

    2016

  49. Clinical Immunology I

    2016

  50. 免疫検査学実習A

    2016

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  51. Clinical Immunology II

    2016

  52. 生体防御学

    2016

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  53. 検査技術科学特論Ⅳ(病因系)

    2016

  54. 病因検査技術開発法Ⅱ

    2016

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  55. 免疫学実習

    2016

     詳細を見る

    免疫学実験の最も基礎である免疫操作法,採血法,血清の分離法,免疫細胞の調製法を修
    得する。さらに血清を用いた赤血球凝集反応,マウスを用いたアナフィラキシー反応と移植
    免疫実験を行う。

  56. 病因病態解析学特論

    2016

  57. 臨床病態解析学概論

    2016

  58. Immunology

    2015

  59. Clinical Immunology I

    2015

  60. 免疫検査学実習A

    2015

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  61. Clinical Immunology II

    2015

  62. 生体防御学

    2015

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  63. 検査技術科学特論Ⅳ(病因系)

    2015

  64. 病因検査技術開発法Ⅱ

    2015

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  65. 免疫学実習

    2015

     詳細を見る

    免疫学実験の最も基礎である免疫操作法,採血法,血清の分離法,免疫細胞の調製法を修
    得する。さらに血清を用いた赤血球凝集反応,マウスを用いたアナフィラキシー反応と移植
    免疫実験を行う。

  66. 病因病態解析学特論

    2015

  67. 臨床病態解析学概論

    2015

  68. Immunology

    2014

  69. Clinical Immunology I

    2014

  70. 免疫検査学実習A

    2014

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  71. Clinical Immunology II

    2014

  72. 生体防御学

    2014

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  73. 病因検査技術開発法Ⅱ

    2014

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  74. 病因検査技術開発法Ⅱ

    2014

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  75. 免疫学実習

    2014

     詳細を見る

    免疫学実験の最も基礎である免疫操作法,採血法,血清の分離法,免疫細胞の調製法を修
    得する。さらに血清を用いた赤血球凝集反応,マウスを用いたアナフィラキシー反応と移植
    免疫実験を行う。

  76. 病因病態解析学特論

    2014

  77. 臨床病態解析学概論

    2014

  78. Immunology

    2013

  79. Clinical Immunology I

    2013

  80. 免疫検査学実習A

    2013

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  81. Clinical Immunology II

    2013

  82. 生体防御学

    2013

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  83. 検査技術科学特論Ⅳ(病因系)

    2013

  84. 病因検査技術開発法Ⅱ

    2013

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  85. 免疫学実習

    2013

     詳細を見る

    免疫学実験の最も基礎である免疫操作法,採血法,血清の分離法,免疫細胞の調製法を修
    得する。さらに血清を用いた赤血球凝集反応,マウスを用いたアナフィラキシー反応と移植
    免疫実験を行う。

  86. 病因病態解析学特論

    2013

  87. 臨床病態解析学概論

    2013

  88. Immunology

    2012

  89. Clinical Immunology I

    2012

  90. 免疫検査学実習A

    2012

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  91. Clinical Immunology II

    2012

  92. 生体防御学

    2012

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  93. 検査技術科学特論Ⅳ(病因系)

    2012

  94. 病因検査技術開発法Ⅱ

    2012

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  95. 免疫学実習

    2012

     詳細を見る

    免疫学実験の最も基礎である免疫操作法,採血法,血清の分離法,免疫細胞の調製法を修
    得する。さらに血清を用いた赤血球凝集反応,マウスを用いたアナフィラキシー反応と移植
    免疫実験を行う。

  96. 病因病態解析学特論

    2012

  97. 臨床病態解析学概論

    2012

  98. First Year Seminar A

    2011

  99. Immunology

    2011

  100. Clinical Immunology I

    2011

  101. 免疫学実習

    2011

     詳細を見る

    免疫学実験の最も基礎である免疫操作法,採血法,血清の分離法,免疫細胞の調製法を修
    得する。さらに血清を用いた赤血球凝集反応,マウスを用いたアナフィラキシー反応と移植
    免疫実験を行う。

  102. 免疫検査学実習A

    2011

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  103. Clinical Immunology II

    2011

  104. 生体防御学

    2011

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  105. 検査技術科学特論Ⅳ(病因系)

    2011

  106. 病因検査技術開発法Ⅱ

    2011

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  107. 病因病態解析学特論

    2011

  108. 臨床病態解析学概論

    2011

  109. Immunology

    2010

  110. 病因病態解析学特論

    2010

  111. 臨床病態解析学概論

    2010

  112. 性差の保健医学

    2010

  113. 生体防御学

    2010

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  114. 病因検査技術開発法Ⅱ

    2010

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  115. 免疫検査学実習A

    2010

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  116. 免疫学実習

    2010

     詳細を見る

    免疫学実験の最も基礎である免疫操作法,採血法,血清の分離法,免疫細胞の調製法を修
    得する。さらに血清を用いた赤血球凝集反応,マウスを用いたアナフィラキシー反応と移植
    免疫実験を行う。

  117. Clinical Immunology II

    2010

  118. Clinical Immunology I

    2010

  119. 検査技術科学特論Ⅳ(病因系)

    2010

  120. 基礎セミナーA

    2009

  121. 性差の保健医学

    2009

  122. 病因病態解析学特論

    2009

  123. 臨床病態解析学概論

    2009

  124. 生体防御学

    2009

     詳細を見る

    健康な状態を維持するためには外部からの攻撃ばかりでなく内部で起こる異常に対しても生体を防御する機構が必要である。本科目では,免疫学を理解するために必要である基礎的な知識を中心に習得することを目標とする。生体内における免疫応答の原理と特徴を明らかにし、その破綻による疾患の病態生理についてもアレルギーと自己免疫病、また感染症に対する免疫応答を例に講義する。

  125. 病因検査技術開発法Ⅱ

    2009

     詳細を見る

    免疫学実習と免疫検査学実習Aで学んだ基礎的技術を基にして,免疫学の新しい実験技術を修得する。

  126. 免疫検査学実習A

    2009

     詳細を見る

    免疫学実習で作製したウサギの抗血清を用いた沈降反応,補体を用いた免疫測定法および
    免疫細胞の解析法として,抗体産生細胞の検出,マイトジェンに対するリンパ球の増殖答応,
    フローサイトメトリーを実習する。

  127. 免疫学実習

    2009

     詳細を見る

    免疫学実験の最も基礎である免疫操作法,採血法,血清の分離法,免疫細胞の調製法を修
    得する。さらに血清を用いた赤血球凝集反応,マウスを用いたアナフィラキシー反応と移植
    免疫実験を行う。

  128. Clinical Immunology II

    2009

  129. Clinical Immunology I

    2009

  130. Immunology

    2009

  131. 検査技術科学特論Ⅳ(病因系)

    2008

  132. 病理組織細胞検査学Ⅱ

    2008

  133. 病理組織細胞検査学実習B

    2008

▼display all

 

Social Contribution 18

  1. アレルギー週間事業市民公開講座 皮膚・感染症とアレルギーの関係を学ぶ

    Role(s):Appearance

    日本アレルギー協会東海支部  2022.2

  2. 日本アレルギー協会東海支部 第28回市民公開講座

    Role(s):Presenter, Planner, Organizing member

    日本アレルギー協会東海支部  2022.2

  3. 公害保健福祉事業 令和元年度呼吸ラクラク教室

    Role(s):Lecturer

    知多保健所(共催:東海市)  東海市  2019.6

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    Audience: Civic organization, Governmental agency

    Type:Lecture

  4. 研究会「公害健康被害と喫煙問題」パネルディスカッション ディスカッサント

    大気汚染公害認定研究会  第48回大気汚染公害認定研究会 研究会「公害健康被害と喫煙問題」パネルディスカッション  2019.2

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    Audience: Scientific, Governmental agency

    Type:Lecture

  5. 名古屋市 ぜん息講演会

    Role(s):Lecturer

    名古屋市  名古屋市役所東庁舎  2019.2

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    Audience: Civic organization, Governmental agency

    Type:Lecture

  6. 肺機能及び閉塞性肺疾患とその予防について

    Role(s):Lecturer

    名古屋市  名古屋市成人喘息教室  2018.11

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    Audience: General

    Type:Lecture

  7. 光コヒーレンストモグラフィ(optical coherence tomography)を用いたイメージングと形態計測による肺組織の評価について

    Role(s):Lecturer

    日本レーザー医学会  第39回日本レーザー医学会総会 シンポジウムVII  京王プラザホテル  2018.11

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    Audience: Scientific

    Type:Seminar, workshop

  8. 気管支鏡検査と呼吸生理: Functional Bronchology 生理機能ならびに形態計測による末梢気道評価について呼吸器内視鏡の可能性

    Role(s):Lecturer

    日本呼吸器内視鏡学会  第23回呼吸器インターベンションセミナー  湯本富士屋ホテル  2018.6

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    Audience: Scientific

    Type:Seminar, workshop

  9. 公害保健福祉事業 平成30年度呼吸ラクラク教室

    Role(s):Lecturer

    知多保健所(共催:東海市)  東海市  2018.6

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    Audience: Civic organization, Governmental agency

    Type:Lecture

  10. 「肺における血中薬物の吸収・排泄機構に関する研究会」の趣旨および研究の経緯

    Role(s):Lecturer

    科学技術交流財団 「肺における血中薬物の吸収・排泄機構に関する研究会   公開セミナー「呼気による血中薬物のモニタリングを目指して」  ウインクあいち15階 科学技術交流財団 研究交流センター  2017.12

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    Audience: Scientific

    Type:Seminar, workshop

  11. 安城医師会研修会

    2011.2

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    全身疾患としてとらえるべきCOPD(慢性閉塞性肺疾患)の臨床

  12. 内科臨床研究会

    2010.9

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    COPD:取り残された生活習慣病

  13. 名古屋市東区医師会「山吹・旭が丘班合同班会」

    2009.11

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    喘息治療とロイコトリエン受容体拮抗薬の位置付け

  14. 内科臨床研究会

    2009.5

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    I型アレルギーの新規診断法の開発~食物アレルギーの診断に向けて

  15. 第4回名大臨床検査フォーラム

    2009.2

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    臨床現場としての検査室を中心とした臨床研究について

  16. 名古屋大学 予防早期医療創成センター 第2回シンポジウム

    2008.1

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    「アレルギー疾患の高精度診断法」
    予防早期医療の実現を目指して ~手のひらに名医・大病院を~

  17. 療養指導保健師等業務研修会

    2007.4

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    COPDの病態生理と予防について

  18. 第14回名古屋IBD定例会

    2006.5

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    疾患理解のための免疫の基礎

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Academic Activities 1

  1. 公益財団法人日本アレルギー協会

    2016.8

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    理事・東海支部長