Updated on 2021/07/26

写真a

 
MUROHARA, Toyoaki
 
Organization
Graduate School of Medicine Program in Integrated Medicine Internal Medicine Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor

Degree 2

  1. Medical Doctor ( 1992.3   Kumamoto University ) 

  2. 医学博士 ( 1992   熊本大学 ) 

Research Interests 1

  1. Vascular Biology, Vascular Regenerarion, Therapeutic Angiogenesis, Regenerative Medicine, Endothelial cell, Bone marrow stem cell, Cardiovascular Medicine, Hypertension, Hyperlipidemia, Renin-Angiotensin System

Research Areas 1

  1. Others / Others  / Circulatory Organs Internal Medicine

Current Research Project and SDGs 1

  1. Regenerative Medicine

Research History 11

  1. Department of Cardiology, Nagoya University Graduate School of Medicine

    2002.6

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    Country:Japan

  2. Department of Internal Medicine III, Kurume University School of Medicine

    1997.7 - 2002.5

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    Country:Japan

  3. Department of Cardiology, St. Elizabeth's Medical Center, Tufts University School of Medicine

    1996.3 - 1997.6

  4. Department of Physiology, Jefferson Medical School of Thomas Jefferson University

    1993.9 - 1996.2

  5. Saiseikai Kumamoto Hospital

    1992.7 - 1993.8

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    Country:Japan

  6. Department of Cardiology, Kumamoto University Medical School

    1992.4 - 1992.6

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    Country:Japan

  7. National Kumamoto Hospital

    1987.4 - 1988.3

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    Country:Japan

  8. Department of Cardiology, Kumamoto University Medical School

    1986.10 - 1987.3

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    Country:Japan

  9. Kumamoto Chuou Hospital

    1986.4 - 1986.9

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    Country:Japan

  10. Miyazaki Prefectural Nobeoka Hospital

    1985.12 - 1986.3

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    Country:Japan

  11. Department of Cardiology, Kumamoto University Medical School

    1985.5 - 1985.11

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    Country:Japan

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Education 2

  1. Kumamoto University   Graduate School, Division of Medical Sciences   Internal Medicine

    1988.4 - 1992.3

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    Country: Japan

  2. Kumamoto University   Faculty of Medicine

    1979.4 - 1985.3

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    Country: Japan

Professional Memberships 8

  1. Japanese Circulation Society

    2008.4

  2. American Heart Association   FAHA

    1999.4

  3. Japanese Society of Internal Medicine

  4. 日本高血圧学会   評議員

    2006.4

  5. 日本心不全学会   理事

    2009.4

  6. 日本動脈硬化学会

  7. European Society of Cardiology   Fellow

    2013.1

  8. 日本血管生物医学会   理事

    2011.4

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Papers 317

  1. Associations between hemodynamic parameters at rest and exercise capacity in patients with implantable left ventricular assist devices

    Kondo Toru, Okumura Takahiro, Oishi Hideo, Arao Yoshihito, Kato Hiroo, Yamaguchi Shogo, Kuwayama Tasuku, Haga Tomoaki, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Fukaya Kenji, Sawamura Akinori, Morimoto Ryota, Mutsuga Masato, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 3 ) page: 174 - 180   2021.3

  2. Predictors of residual mitral regurgitation after left ventricular assist device implantation

    Kimura Yuki, Okumura Takahiro, Kazama Shingo, Shibata Naoki, Oishi Hideo, Arao Yoshihito, Kuwayama Tasuku, Kato Hiroo, Yamaguchi Shogo, Hiraiwa Hiroaki, Kondo Toru, Morimoto Ryota, Mutsuga Masato, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 2 ) page: 101 - 109   2021.2

  3. The mechanism and prognosis of acute and late improvement in mitral regurgitation after cardiac resynchronization therapy

    Okamoto Hiroya, Inden Yasuya, Yanagisawa Satoshi, Fujii Aya, Tomomatsu Toshiro, Mamiya Keita, Riku Shuro, Suga Kazumasa, Furui Koichi, Nakagomi Toshifumi, Shibata Rei, Murohara Toyoaki

    HEART AND VESSELS     2021.1

  4. A clinical score for predicting left ventricular reverse remodelling in patients with dilated cardiomyopathy

    Kimura Yuki, Okumura Takahiro, Morimoto Ryota, Kazama Shingo, Shibata Naoki, Oishi Hideo, Araki Takashi, Mizutani Takashi, Kuwayama Tasuku, Hiraiwa Hiroaki, Kondo Toru, Murohara Toyoaki

    ESC HEART FAILURE     2021.1

  5. Bioinformatics analysis of autophagy-lysosomal degradation in cardiac aging

    Kamihara Takahiro, Murohara Toyoaki

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 21 ( 1 ) page: 108 - 115   2021.1

  6. Early improvement of daily physical activity after catheter ablation for atrial fibrillation in an accelerometer assessment: A prospective pilot study

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Sakamoto Yusuke, Tomomatsu Toshiro, Mamiya Keita, Okamoto Hiroya, Murohara Toyoaki, Shibata Rei

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   Vol. 26 ( 1 )   2021.1

  7. No influence on tumor growth by intramuscular injection of adipose-derived regenerative cells: safety evaluation of therapeutic angiogenesis with cell therapy

    Suzuki Junya, Shimizu Yuuki, Tsuzuki Kazuhito, Pu Zhongyue, Narita Shingo, Yamaguchi Shukuro, Katagiri Takeshi, Iwata Etsuo, Masutomi Tomohiro, Fujikawa Yusuke, Shibata Rei, Murohara Toyoaki

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   Vol. 320 ( 1 ) page: H447 - H457   2021.1

  8. Adipolin/C1q/Tnf-related protein 12 prevents adverse cardiac remodeling after myocardial infarction

    Takikawa Tomonobu, Ohashi Koji, Ogawa Hayato, Otaka Naoya, Kawanishi Hiroshi, Fang Lixin, Ozaki Yuta, Eguchi Shunsuke, Tatsumi Minako, Takefuji Mikito, Murohara Toyoaki, Ouchi Noriyuki

    PLOS ONE   Vol. 15 ( 12 )   2020.12

  9. The prognostic impact of right ventricular dysfunction in patients with septic cardiomyopathy

    Hiraiwa H., Kasugai D., Okumura T., Kazama S., Kimura Y., Shibata N., Arao Y., Oishi H., Kato H., Kuwayama T., Yamaguchi S., Kondo T., Furusawa K., Morimoto R., Murohara T.

    EUROPEAN HEART JOURNAL   Vol. 41   page: 1836 - 1836   2020.11

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  10. Differential Diagnosis of Mechanisms of Exercise-Induced Abnormal Blood Pressure Response in Hypertrophic Cardiomyopathy Without Left Ventricular Outflow Tract Obstruction

    Okumura Takahiro, Kano Naoaki, Sawamura Akinori, Kondo Toru, Hiraiwa Hiroaki, Morimoto Ryota, Murohara Toyoaki

    CIRCULATION-HEART FAILURE   Vol. 13 ( 10 )   2020.10

  11. Heart Failure and Cancer - A Comorbid Risk That Is No Longer Underestimated -

    Kazama Shingo, Bando Yasuko K., Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 84 ( 10 ) page: 1689 - 1690   2020.10

  12. Impella 5.0 for Cardiogenic Shock After Thrombectomy in a Patient With Intraventricular Thrombosis

    Kimura Yuki, Kondo Toru, Mutsuga Masato, Morimoto Ryota, Kazama Shingo, Shibata Naoki, Oishi Hideo, Arao Yoshihito, Kuwayama Tasuku, Kato Hiroo, Yamaguchi Shogo, Hiraiwa Hiroaki, Okumura Takahiro, Fujimoto Kazuro, Usui Akihiko, Murohara Toyoaki

    CANADIAN JOURNAL OF CARDIOLOGY   Vol. 36 ( 10 )   2020.10

  13. Therapeutic angiogenesis using autologous adipose-derived regenerative cells in patients with critical limb ischaemia in Japan: a clinical pilot study

    Katagiri Takeshi, Kondo Kazuhisa, Shibata Rei, Hayashida Ryo, Shintani Satoshi, Yamaguchi Shukuro, Shimizu Yuuki, Unno Kazumasa, Kikuchi Ryosuke, Kodama Akio, Takanari Keisuke, Kamei Yuzuru, Komori Kimihiro, Murohara Toyoaki

    SCIENTIFIC REPORTS   Vol. 10 ( 1 )   2020.9

  14. Efficacy of Pulmonary Artery Pulsatility Index as a Measure of Right Ventricular Dysfunction in Stable Phase of Dilated Cardiomyopathy

    Kuwayama Tasuku, Morimoto Ryota, Oishi Hideo, Kato Hiroo, Kimura Yuki, Kazama Shingo, Shibata Naoki, Arao Yoshihito, Yamaguchi Shogo, Hiraiwa Hiroaki, Kondo Toru, Furusawa Kenji, Okumura Takahiro, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 84 ( 9 ) page: 1536 - +   2020.9

  15. Single-center prognostic validation of the risk assessment of the 2015 ESC/ERS guidelines in patients with pulmonary arterial hypertension in Japan

    Imai Ryo, Adachi Shiro, Yoshida Masahiro, Shimokata Shigetake, Nakano Yoshihisa, Okumura Naoki, Murohara Toyoaki, Kondo Takahisa

    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY   Vol. 98 ( 9 ) page: 653 - 658   2020.9

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  16. C1q/TNF-Related Protein 9 Promotes Revascularization in Response to Ischemiaviaan eNOS-Dependent Manner

    Yamaguchi Shukuro, Shibata Rei, Ohashi Koji, Enomoto Takashi, Ogawa Hayato, Otaka Naoya, Hiramatsu-Ito Mizuho, Masutomi Tomohiro, Kawanishi Hiroshi, Murohara Toyoaki, Ouchi Noriyuki

    FRONTIERS IN PHARMACOLOGY   Vol. 11   2020.8

  17. Role of Cryptochrome in Angiogenesis

    Tsuzuki Kazuhito, Shimizu Yuuki, Pu Zhongyue, Suzuki Jyunya, Murohara Toyoaki

    CIRCULATION RESEARCH   Vol. 127   2020.7

  18. Usefulness of Plasma Branched-Chain Amino Acid Analysis in Predicting Outcomes of Patients with Nonischemic Dilated Cardiomyopathy

    Kimura Yuki, Okumura Takahiro, Kazama Shingo, Shibata Naoki, Oishi Hideo, Arao Yoshihito, Kuwayama Tasuku, Kato Hiroo, Yamaguchi Shogo, Hiraiwa Hiroaki, Kondo Toru, Morimoto Ryota, Murohara Toyoaki

    INTERNATIONAL HEART JOURNAL   Vol. 61 ( 4 ) page: 739 - 747   2020.7

  19. A novel selective PPAR alpha modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms

    Kawanishi Hiroshi, Ohashi Koji, Ogawa Hayato, Otaka Naoya, Takikawa Tomonobu, Fang Lixin, Ozaki Yuta, Takefuji Mikito, Murohara Toyoaki, Ouchi Noriyuki

    PLOS ONE   Vol. 15 ( 6 )   2020.6

  20. Can Pharmacological Ischemic Preconditioning Affect Myocardial Ischemic Injury?

    Ohashi Koji, Ouchi Noriyuki, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 84 ( 6 ) page: 891 - 893   2020.6

  21. Prediction of Thromboembolism in Patients With Hypertrophic Cardiomyopathy

    Okumura Takahiro, Kimura Yuki, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 84 ( 5 ) page: 700 - 701   2020.5

  22. Lipid-rich large plaques in a non-culprit left main coronary artery and long-term clinical outcomes

    Tashiro Hiroshi, Tanaka Akihito, Ishii Hideki, Sakakibara Keisuke, Tobe Akihiro, Kataoka Takashi, Miki Yusuke, Hitora Yusuke, Niwa Kiyoshi, Furusawa Kenji, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 305   page: 5 - 10   2020.4

  23. Therapeutic Angiogenesis Using Bone Marrow Mononuclear Cell Transplantation - A New Standard Treatment for Thromboangiitis Obliterans?

    Shibata Rei, Yamaguchi Shukuro, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 84 ( 4 ) page: 549 - 550   2020.4

  24. Electrocardiogram characteristics of P wave associated with successful pulmonary vein isolation in patients with paroxysmal atrial fibrillation: Significance of changes in P-wave duration and notched P wave

    Yanagisawa Satoshi, Inden Yasuya, Okamoto Hiroya, Fujii Aya, Sakamoto Yusuke, Mamiya Keita, Tomomatsu Toshiro, Shibata Rei, Murohara Toyoaki

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   Vol. 25 ( 2 )   2020.3

  25. The role of lymphangiogenesis in ischemia-induced angiogenesis for peripheral artery disease

    Pu Zhongyue, Shimizu Yuuki, Murohara Toyoaki

    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY   Vol. 140   page: 16 - 17   2020.3

  26. Anatomical assessment of crosstalk phenomenon during laser balloon ablation with imaging in a patient with unusual atrial hypertrophy

    Yanagisawa Satoshi, Inden Yasuya, Okamoto Hiroya, Tomomatsu Toshiro, Fujii Aya, Mamiya Keita, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 57 ( 1 ) page: 157 - 159   2020.1

  27. Advantages and Emerging Problems of Novel Treatments for Transthyretin Cardiac Amyloidosis

    Okumura Takahiro, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 84 ( 1 ) page: 9 - 10   2020.1

  28. Therapeutic Angiogenesis with Somatic Stem Cell Transplantation

    Murohara Toyoaki

    KOREAN CIRCULATION JOURNAL   Vol. 50 ( 1 ) page: 12 - 21   2020.1

  29. Impact of Diabetes Mellitus on the Aortic Wall Changes as Atherosclerosis Progresses: Aortic Dilatation and Calcification

    Iwakawa Naoki, Tanaka Akihito, Ishii Hideki, Kataoka Takashi, Niwa Kiyoshi, Hitora Yusuke, Tashiro Hiroshi, Mitsuda Takayuki, Kojima Hiroki, Hirayama Kenshi, Furusawa Kenji, Yoshida Ruka, Suzuki Susumu, Murohara Toyoaki

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   Vol. 27 ( 6 ) page: 509 - 515   2020

  30. Prognostic impact of mitral L-wave in patients with hypertrophic cardiomyopathy without risk factors for sudden cardiac death

    Sugiura Yuki, Morimoto Ryota, Aoki Soichiro, Yamaguchi Shogo, Haga Tomoaki, Kuwayama Tasuku, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Kondo Toru, Watanabe Naoki, Kano Naoaki, Fukaya Kenji, Sawamura Akinori, Okumura Takahiro, Murohara Toyoaki

    HEART AND VESSELS   Vol. 34 ( 12 ) page: 2002 - 2010   2019.12

  31. Prothrombotic Responses After Catheter Ablation for Atrial Fibrillation During Uninterrupted Oral Anticoagulant Agent Administration

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Sakamoto Yusuke, Tomomatsu Toshiro, Mamiya Keita, Okamoto Hiroya, Shibata Rei, Murohara Toyoaki

    JACC-CLINICAL ELECTROPHYSIOLOGY   Vol. 5 ( 12 ) page: 1418 - 1427   2019.12

  32. Heart rate control using beta-blockers for heart failure with atrial fibrillation: more than enough is too much

    Okumura Takahiro, Kimura Yuki, Murohara Toyoaki

    HYPERTENSION RESEARCH   Vol. 42 ( 11 ) page: 1826 - 1827   2019.11

  33. How Do We Improve the Utility of Fractional Flow Reserve? - For Precise Diagnosis of Myocardial Ischemia -

    Ishii Hideki, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 83 ( 10 ) page: 1986 - 1987   2019.10

  34. Effects of Tobacco Smoking on Cardiovascular Disease

    Kondo Takahisa, Nakano Yoshihisa, Adachi Shiro, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 83 ( 10 ) page: 1980 - 1985   2019.10

  35. Early blood pressure reduction by intravenous vasodilators associates with acute kidney injury in patients with hypertensive acute decompensated heart failure

    Arao Y., Sawamura A., Nakatochi M., Oishi H., Kato H., Yamaguchi S., Haga T., Kuwayama T., Yokoi T., Hiraiwa H., Kondo T., Morimoto R., Okumura T., Murohara T.

    EUROPEAN HEART JOURNAL   Vol. 40   page: 884 - 884   2019.10

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  36. Unsolved Issue in Left Ventricular Noncompaction: Is the Strange Form of Myocardium Congenital or Acquired?

    Okumura Takahiro, Murohara Toyoaki

    CARDIOLOGY   Vol. 143 ( 3-4 ) page: 105 - 106   2019.10

  37. Kidney Measures to Improve Risk Discrimination of Cardiovascular Events

    Ishii Hideki, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 83 ( 9 ) page: 1836 - 1837   2019.9

  38. T-wave changes of cardiac memory caused by frequent premature ventricular contractions originating from the right ventricular outflow tract

    Sakamoto Yusuke, Inden Yasuya, Okamoto Hiroya, Mamiya Keita, Tomomatsu Toshiro, Fujii Aya, Yanagisawa Satoshi, Shibata Rei, Hirai Makoto, Murohara Toyoaki

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 30 ( 9 ) page: 1549 - 1556   2019.9

  39. Adipolin/C1q/Tnf-related Protein 12 reduces Neointimal Formation And Atherosclerotic Lesion Development By Modulation Of Macrophage Inflammatory Response And Endothelial Cell Function

    Ohashi Koji, Ogawa Hayato, Enomoto Takashi, Otaka Naoya, Murohara Toyoaki, Ouchi Noriyuki

    CIRCULATION RESEARCH   Vol. 125   2019.8

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  40. Cardiomyocytes capture stem cell-derived, anti-apoptotic microRNA-214 via clathrin-mediated endocytosis in acute myocardial infarction

    Eguchi Shunsuke, Takefuji Mikito, Sakaguchi Teruhiro, Ishihama Sohta, Mori Yu, Tsuda Takuma, Takikawa Tomonobu, Yoshida Tatsuya, Ohashi Koji, Shimizu Yuuki, Hayashida Ryo, Kondo Kazuhisa, Bando Yasuko K., Ouchi Noriyuki, Murohara Toyoaki

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 294 ( 31 ) page: 11665 - 11674   2019.8

  41. Impaired Autophagic Off-rate Causes Cardiac Aging in Progeria Mouse Model

    Bando Yasuko K., Kamihara Takahiro, Murohara Toyoaki

    CIRCULATION RESEARCH   Vol. 125   2019.8

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  42. Identification of precise accessory pathway using ultra-high-resolution three-dimensional mapping system: utility and feasibility in preliminary experience

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Sakamoto Yusuke, Ichiyanagi Hiroshi, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 55 ( 2 ) page: 241 - 242   2019.8

  43. His bundle pacing with unusual automaticity

    Yanagisawa Satoshi, Inden Yasuya, Shibata Rei, Murohara Toyoaki

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 30 ( 6 ) page: 966 - 968   2019.6

  44. Renin Activity as a Key Predictor of Major Adverse Cardiac Events

    Kondo Takahisa, Nakano Yoshihisa, Adachi Shiro, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 83 ( 6 ) page: 1204 - 1205   2019.6

  45. Adjacentmultiple accessory pathways demonstrated on ultra-high-resolution mapping

    Yanagisawa Satoshi, Inden Yasuya, Murohara Toyoaki

    EUROPACE   Vol. 21 ( 5 ) page: 723 - 723   2019.5

  46. Circulation Journal Awards for the Year 2018

    Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 83 ( 3 ) page: 495 - 503   2019.3

  47. Myocardial viability as shown by left ventricular lead pacing threshold and improved dyssynchrony by QRS narrowing predicts the response to cardiac resynchronization therapy

    Takenaka Masaki, Inden Yasuya, Yanagisawa Satoshi, Fujii Aya, Ando Monami, Funabiki Junya, Murase Yosuke, Otake Noriaki, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 30 ( 3 ) page: 311 - 319   2019.3

  48. Contrast-Induced Nephropathy and Long-Term Clinical Outcomes Following Percutaneous Coronary Intervention in Patients With Advanced Renal Dysfunction (Estimated Glomerular Filtration Rate &lt;30 ml/min/1.73 m<sup>2</sup>).

    Negishi Y, Tanaka A, Ishii H, Takagi K, Inoue Y, Uemura Y, Umemoto N, Yoshioka N, Morishima I, Asano H, Watarai M, Shibata N, Suzuki S, Murohara T

    The American journal of cardiology   Vol. 123 ( 3 ) page: 361-367   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.amjcard.2018.10.038

    PubMed

  49. Prognostic value of left ventricular dyssynchrony evaluated by gated myocardial perfusion imaging in patients with chronic kidney disease and normal perfusion defect scores.

    Mori H, Isobe S, Suzuki S, Unno K, Morimoto R, Kano N, Okumura T, Yasuda Y, Kato K, Murohara T

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology   Vol. 26 ( 1 ) page: 288 - 297   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12350-017-0889-9

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  50. Corticotropin-Releasing Hormone Family and Their Receptors in the Cardiovascular System.

    Takefuji M, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 83 ( 2 ) page: 261 - 266   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-18-0428

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  51. Editorial Statistics and Best Reviewers Award for 2018.

    Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 83 ( 2 ) page: 249 - 251   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-66-0160

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  52. Differential effect of concomitant antidiabetic agents on carotid atherosclerosis: a subgroup analysis of the PROLOGUE study.

    Tanaka A, Kawaguchi A, Oyama JI, Ishizu T, Ito H, Fukui J, Kondo T, Kuroki S, Nanasato M, Higashi Y, Kaku K, Inoue T, Murohara T, Node K

    Heart and vessels   Vol. 34 ( 2 ) page: 375-384   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00380-018-1275-5

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  53. Pulmonary Hypertension: Diagnosis, Management, and Treatment

    Kondo Takahisa, Okumura Naoki, Adachi Shiro, Murohara Toyoaki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 1 ) page: 19 - 30   2019.2

  54. Impact of adjunctive use of guide extension catheter for mid-term outcome of drug-coated balloon.

    Yoshida R, Ishii H, Morishima I, Tanaka A, Takagi K, Iwakawa N, Tashiro H, Kojima H, Mitsuda T, Hirayama K, Hitora Y, Furusawa K, Murohara T

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.4244/EIJ-D-18-01013

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  55. Hemodynamics of cardiac tamponade during extracorporeal membrane oxygenation support in a patient with fulminant myocarditis.

    Kondo T, Morimoto R, Yokoi T, Yamaguchi S, Kuwayama T, Haga T, Hiraiwa H, Sugiura Y, Watanabe N, Kano N, Ichii T, Fukaya K, Sawamura A, Okumura T, Yoshizumi T, Mutsuga M, Fujimoto K, Matsuda N, Usui A, Murohara T

    Journal of cardiology cases   Vol. 19 ( 1 ) page: 22-24   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jccase.2018.08.009

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  56. Anti-angiogenic isoform of vascular endothelial growth factor-A in cardiovascular and renal disease.

    Kikuchi R, Stevens M, Harada K, Oltean S, Murohara T

    Advances in clinical chemistry   Vol. 88   page: 1-33   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/bs.acc.2018.10.001

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  57. Performance of HAS-BLED, ORBIT, PRECISE-DAPT, and PARIS risk score for predicting long-term bleeding events in patients taking an oral anticoagulant undergoing percutaneous coronary intervention.

    Yoshida R, Ishii H, Morishima I, Tanaka A, Morita Y, Takagi K, Yoshioka N, Hirayama K, Iwakawa N, Tashiro H, Kojima H, Mitsuda T, Hitora Y, Furusawa K, Tsuboi H, Murohara T

    Journal of cardiology     2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jjcc.2018.10.013

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  58. Impact of Nutritional and Inflammation Status on Long-Term Bleeding in Patients Undergoing Percutaneous Coronary Intervention with an Oral Anticoagulant.

    Yoshida R, Ishii H, Morishima I, Tanaka A, Morita Y, Takagi K, Yoshioka N, Hirayama K, Iwakawa N, Tashiro H, Kojima H, Mitsuda T, Hitora Y, Furusawa K, Tsuboi H, Murohara T

    Journal of atherosclerosis and thrombosis     2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.47654

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  59. Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial.

    J-DAVID Investigators., Shoji T, Inaba M, Fukagawa M, Ando R, Emoto M, Fujii H, Fujimori A, Fukui M, Hase H, Hashimoto T, Hirakata H, Honda H, Hosoya T, Ikari Y, Inaguma D, Inoue T, Isaka Y, Iseki K, Ishimura E, Itami N, Ito C, Kakuta T, Kawai T, Kawanishi H, Kobayashi S, Kumagai J, Maekawa K, Masakane I, Minakuchi J, Mitsuiki K, Mizuguchi T, Morimoto S, Murohara T, Nakatani T, Negi S, Nishi S, Nishikawa M, Ogawa T, Ohta K, Ohtake T, Okamura M, Okuno S, Shigematsu T, Sugimoto T, Suzuki M, Tahara H, Takemoto Y, Tanaka K, Tominaga Y, Tsubakihara Y, Tsujimoto Y, Tsuruya K, Ueda S, Watanabe Y, Yamagata K, Yamakawa T, Yano S, Yokoyama K, Yorioka N, Yoshiyama M, Nishizawa Y

    JAMA   Vol. 320 ( 22 ) page: 2325-2334   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jama.2018.17749

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  60. Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury

    Otaka Naoya, Shibata Rei, Ohashi Koji, Uemura Yusuke, Kambara Takahiro, Enomoto Takashi, Ogawa Hayato, Ito Masanori, Kawanishi Hiroshi, Maruyama Sonomi, Joki Yusuke, Fujikawa Yusuke, Narita Shingo, Unno Kazumasa, Kawamoto Yoshiyuki, Murate Takashi, Murohara Toyoaki, Ouchi Noriyuki

    CIRCULATION RESEARCH   Vol. 123 ( 12 ) page: 1326-1338   2018.12

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    DOI: 10.1161/CIRCRESAHA.118.313777

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  61. A Novel Selective PPAR[alpha] Modulator, Pemafibrate Promotes Ischemia-Induced Revascularization

    Kawanishi Hiroshi, Ohashi Koji, Shibata Rei, Murohara Toyoaki, Ouchi Noriyuki

    CIRCULATION   Vol. 138   2018.11

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  62. Maintenance of Undifferentiated Mesenchymal Stromal Cells-Like Fibroblast by Meflin is Crucial for Heart Repair and Homeostasis

    Hara Akitoshi, Enomoto Atsushi, Murohara Toyoaki

    CIRCULATION   Vol. 138   2018.11

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  63. Physiological Glucagon Acts as a Guardian of the Heart Against Catecholamine Surge Induced by Pressure-Overload

    Nishimura Kazuyuki, Bando Yasuko K., Kamihara Takahiro, Ozaki Reina, Yasheng Remina, Murohara Toyoaki

    CIRCULATION   Vol. 138   2018.11

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  64. Achieving LDL cholesterol target levels &lt;1.81 mmol/L may provide extra cardiovascular protection in patients at high risk: Exploratory analysis of the Standard Versus Intensive Statin Therapy for Patients with Hypercholesterolaemia and Diabetic Retinopathy study.

    Itoh H, Komuro I, Takeuchi M, Akasaka T, Daida H, Egashira Y, Fujita H, Higaki J, Hirata KI, Ishibashi S, Isshiki T, Ito S, Kashiwagi A, Kato S, Kitagawa K, Kitakaze M, Kitazono T, Kurabayashi M, Miyauchi K, Murakami T, Murohara T, Node K, Ogawa S, Saito Y, Seino Y, Shigeeda T, Shindo S, Sugawara M, Sugiyama S, Terauchi Y, Tsutsui H, Ueshima K, Utsunomiya K, Yamagishi M, Yamazaki T, Yo S, Yokote K, Yoshida K, Yoshimura M, Yoshimura N, Nakao K, Nagai R, EMPATHY Investigators.

    Diabetes, obesity & metabolism     2018.11

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    DOI: 10.1111/dom.13575

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  65. Clinical significance of the timing of early recurrence of atrial arrhythmia after pulmonary vein isolation: a two-institution clinical study.

    Murase Y, Inden Y, Imai H, Kyo S, Yanagisawa S, Fujii A, Sakamoto Y, Tomomatsu T, Murohara T

    Heart and vessels     2018.11

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    DOI: 10.1007/s00380-018-1295-1

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  66. Palliative and end-of-life care for heart failure patients in an aging society

    Okumura Takahiro, Sawamura Akinori, Murohara Toyoaki

    KOREAN JOURNAL OF INTERNAL MEDICINE   Vol. 33 ( 6 ) page: 1039 - 1049   2018.11

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    DOI: 10.3904/kjim.2018.106

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  67. Prognostic Impact of the Preservation of Activities of Daily Living on Post-Discharge Outcomes in Patients With Acute Heart Failure

    Uemura Yusuke, Shibata Rei, Takemoto Kenji, Koyasu Masayoshi, Ishikawa Shinji, Murohara Toyoaki, Watarai Masato

    CIRCULATION JOURNAL   Vol. 82 ( 11 ) page: 2793-+   2018.11

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    DOI: 10.1253/circj.CJ-18-0279

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  68. Impact of periprocedural anticoagulation therapy on the incidence of silent stroke after atrial fibrillation ablation in patients receiving direct oral anticoagulants: uninterrupted vs. interrupted by one dose strategy.

    Nagao T, Suzuki H, Matsunaga S, Nishikawa Y, Harada K, Mamiya K, Shinoda N, Harada K, Kato M, Marui N, Amano T, Inden Y, Murohara T

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     2018.10

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    DOI: 10.1093/europace/euy224

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  69. Impact of Lymphangiogenesis on Cardiac Remodeling After Ischemia and Reperfusion Injury

    Shimizu Yuuki, Polavarapu Rohini, Eskla Kattri-Liis, Pantner Yvanna, Nicholson Chad K., Ishii Masakazu, Brunnhoelzl Daniel, Mauria Rohit, Husain Ahsan, Naqvi Nawazish, Murohara Toyoaki, Calvert John W.

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 7 ( 19 ) page: e009565   2018.10

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    DOI: 10.1161/JAHA.118.009565

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  70. Left ventricular phase entropy: Novel prognostic predictor in patients with dilated cardiomyopathy and narrow QRS.

    Kano N, Okumura T, Isobe S, Sawamura A, Watanabe N, Fukaya K, Mori H, Morimoto R, Kato K, Bando YK, Murohara T

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology   Vol. 25 ( 5 ) page: 1677 - 1687   2018.10

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    DOI: 10.1007/s12350-017-0807-1

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  71. ALTERED CARDIAC AUTONOMIC ACTIVITY, ARRHYTHMIAS, AND CARDIAC DEATH IN A RAT MODEL OF METABOLIC SYNDROME

    Nagata Kohzo, Nakano Shiho, Minamiya Moeko, Azuma Naoki, Mizumoto Hisashi, Yoneda Mamoru, Komatsu Yuki, Aoyama Kiyoshi, Ashikawa Nao, Murohara Toyoaki, Uchinaka Ayako

    JOURNAL OF HYPERTENSION   Vol. 36   page: E71-E71   2018.10

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  72. Trade-Off Between Lipid-Lowering Therapy and Costs in Patients With Cardiovascular Disease

    Ishii Hideki, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 82 ( 10 ) page: 2481 - 2482   2018.10

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    DOI: 10.1253/circj.CJ-18-0811

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  73. Usefulness of scoring right ventricular function for assessment of prognostic factors in patients with chronic thromboembolic pulmonary hypertension

    Kamimura Yoshihiro, Okumura Naoki, Adachi Shiro, Shimokata Shigetake, Tajima Fumitaka, Nakano Yoshihisa, Hirashiki Akihiro, Murohara Toyoaki, Kondo Takahisa

    HEART AND VESSELS   Vol. 33 ( 10 ) page: 1220-1228   2018.10

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    DOI: 10.1007/s00380-018-1168-7

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  74. Adiponectin/AdiopR1 signal inactivation contributes to impaired angiogenesis in mice of advanced age

    Piao Limei, Yu Chenglin, Xu Wenhu, Inoue Aiko, Shibata Rei, Li Xiang, Nan Yongshan, Zhao Guangxian, Wang Hailong, Meng Xiangkun, Lei Yanna, Goto Hiroki, Ouchi Noriyuki, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 267   page: 150-155   2018.9

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    DOI: 10.1016/j.ijcard.2018.05.089

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  75. Influence of chronic kidney disease and worsening renal function on clinical outcomes in patients undergoing primary percutaneous coronary intervention.

    Aoki T, Ishii H, Tanaka A, Suzuki S, Ichimiya S, Kanashiro M, Murohara T

    Clinical and experimental nephrology     2018.9

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    DOI: 10.1007/s10157-018-1622-y

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  76. Comparison of two dosing methods for immediate administration of tolvaptan in acute decompensated heart failure.

    Oguri M, Ishii H, Ohguchi S, Takahara K, Kawamura Y, Yokoi Y, Izumi K, Takahashi H, Kamiya H, Murohara T

    Journal of cardiology   Vol. 72 ( 3 ) page: 234-239   2018.9

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    DOI: 10.1016/j.jjcc.2018.02.006

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  77. Randomized Trial of Effect of Urate-Lowering Agent Febuxostat in Chronic Heart Failure Patients with Hyperuricemia (LEAF-CHF ) Study Design

    Yokota Takashi, Fukushima Arata, Kinugawa Shintaro, Okumura Takahiro, Murohara Toyoaki, Tsutsui Hiroyuki

    INTERNATIONAL HEART JOURNAL   Vol. 59 ( 5 ) page: 976-982   2018.9

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    DOI: 10.1536/ihj.17-560

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  78. Long-term clinical outcomes after coronary artery bypass graft versus everolimus-eluting stent implantation in chronic hemodialysis patients

    Kumada Yoshitaka, Ishii Hideki, Aoyama Toru, Kamoi Daisuke, Sakakibara Takashi, Umemoto Norio, Ito Ryuta, Takahashi Hiroshi, Murohara Toyoaki

    CORONARY ARTERY DISEASE   Vol. 29 ( 6 ) page: 489-494   2018.9

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    DOI: 10.1097/MCA.0000000000000628

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  79. A multicenter prospective cohort study to develop frailty-based prognostic criteria in heart failure patients (FLAGSHIP): rationale and design

    Yamada Sumio, Adachi Takuji, Izawa Hideo, Murohara Toyoaki, Kondo Takaaki

    BMC CARDIOVASCULAR DISORDERS   Vol. 18 ( 1 ) page: 159   2018.8

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    DOI: 10.1186/s12872-018-0897-y

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  80. Comparison Between Long-Term Clinical Outcomes of Vitamin K Antagonist and Direct Oral Anticoagulants in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

    Yoshida Ruka, Morishima Itsuro, Takagi Kensuke, Morita Yasuhiro, Tsuboi Hideyuki, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 82 ( 8 ) page: 2016-+   2018.8

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    DOI: 10.1253/circj.CJ-17-1171

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  81. Promising method for management of venoarterial extracorporeal membrane oxygenation: A case of severe heart failure successfully stabilized by "high-flow/vasodilation method".

    Kondo T, Sawamura A, Okumura T, Kano N, Morimoto R, Watanabe N, Hiraiwa H, Kuwayama T, Sugiura Y, Haga T, Yamaguchi S, Fukaya K, Yokoi T, Fujimoto K, Mutsuga M, Yoshizumi T, Matsuda N, Usui A, Murohara T

    Journal of cardiology cases   Vol. 18 ( 2 ) page: 81-84   2018.8

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    DOI: 10.1016/j.jccase.2018.05.002

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  82. Prognostic Value of Electrocardiography in Patients With Fulminant Myocarditis Supported by Percutaneous Venoarterial Extracorporeal Membrane Oxygenation - Analysis From the CHANGE PUMP Study.

      Vol. 82 ( 8 ) page: 2089-2095   2018.7

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    DOI: 10.1253/circj.CJ-18-0136

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  83. High-Normal Thyroid-Stimulating Hormone Shows a Potential Causal Association With Arrhythmia Recurrence After Catheter Ablation of Atrial Fibrillation

    Morishima Itsuro, Okumura Kenji, Morita Yasuhiro, Kanzaki Yasunori, Takagi Kensuke, Yoshida Ruka, Nagai Hiroaki, Ikai Yoshihiro, Furui Koichi, Yoshioka Naoki, Tsuboi Hideyuki, Murohara Toyoaki

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 7 ( 14 )   2018.7

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    DOI: 10.1161/JAHA.118.009158

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  84. Are Sodium-Glucose Cotransporter 2 Inhibitors Really Useful and Safe for Advanced Heart Failure?

    Okumura Takahiro, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 82 ( 7 ) page: 1752 - 1753   2018.7

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    DOI: 10.1253/circj.CJ-18-0584

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  85. Clinical Impact of Circulating Irisin on Classified Coronary Plaque Characteristics

    Hirayama Kenshi, Ishii Hideki, Kikuchi Ryosuke, Suzuki Susumu, Aoki Toshijiro, Harada Kazuhiro, Sumi Takuya, Negishi Yosuke, Shibata Yohei, Tatami Yosuke, Tanaka Akihito, Murohara Toyoaki

    JOURNAL OF APPLIED LABORATORY MEDICINE   Vol. 3 ( 1 ) page: 79 - 88   2018.7

  86. ADIPOLIN/C1Q/TNF-RELATED PROTEIN 12 ACTS AS A BIOMARKER OF CORONARY ARTERY DISEASE AND PREVENTS THE PATHOLOGICAL VASCULAR REMODELING

    Ogawa Hayato, Ohashi Koji, Murohara Toyoaki, Ouchi Noriyuki

    ATHEROSCLEROSIS SUPPLEMENTS   Vol. 32   page: 10-11   2018.6

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  87. Association between the ratio of anti-angiogenic isoform of VEGF-A to total VEGF-A and adverse clinical outcomes in patients after acute myocardial infarction

    Harada Kazuhiro, Kikuchi Ryosuke, Ishii Hideki, Shibata Yohei, Suzuki Susumu, Tanaka Akihito, Suzuki Atsuo, Hirayama Kenshi, Murohara Toyoaki

    IJC HEART & VASCULATURE   Vol. 19   page: 3-7   2018.6

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    DOI: 10.1016/j.ijcha.2018.03.004

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  88. Nonsustained ventricular tachycardia does not affect the prognosis of neuromuscular diseases: A preliminary and retrospective study

    Kamihara Takahiro, Yasuma Fumihiko, Murohara Toyoaki

    JOURNAL OF ARRHYTHMIA   Vol. 34 ( 3 ) page: 254-260   2018.6

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    DOI: 10.1002/joa3.12057

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  89. Late-Onset Fulminant Myocarditis With Immune Checkpoint Inhibitor Nivolumab

    Yamaguchi Shogo, Morimoto Ryota, Okumura Takahiro, Yamashita Yuta, Haga Tomoaki, Kuwayama Tasuku, Yokoi Tsuyoshi, Hiraiwa Hiroaki, Kondo Toru, Sugiura Yuki, Watanabe Naoki, Kano Naoaki, Kohno Kei, Fukaya Kenji, Sawamura Akinori, Yokota Kenji, Ishii Hideki, Nakaguro Masato, Akiyama Masashi, Murohara Toyoaki

    CANADIAN JOURNAL OF CARDIOLOGY   Vol. 34 ( 6 ) page: 812.e1-812.e3   2018.6

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    DOI: 10.1016/j.cjca.2018.03.007

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  90. Intensive Treat-to-Target Statin Therapy in High-Risk Japanese Patients With Hypercholesterolemia and Diabetic Retinopathy: Report of a Randomized Study.

    Itoh H, Komuro I, Takeuchi M, Akasaka T, Daida H, Egashira Y, Fujita H, Higaki J, Hirata KI, Ishibashi S, Isshiki T, Ito S, Kashiwagi A, Kato S, Kitagawa K, Kitakaze M, Kitazono T, Kurabayashi M, Miyauchi K, Murakami T, Murohara T, Node K, Ogawa S, Saito Y, Seino Y, Shigeeda T, Shindo S, Sugawara M, Sugiyama S, Terauchi Y, Tsutsui H, Ueshima K, Utsunomiya K, Yamagishi M, Yamazaki T, Yo S, Yokote K, Yoshida K, Yoshimura M, Yoshimura N, Nakao K, Nagai R, EMPATHY Investigators.

    Diabetes care   Vol. 41 ( 6 ) page: 1275-1284   2018.6

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    DOI: 10.2337/dc17-2224

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  91. Effects of ramelteon on cardiac injury and adipose tissue pathology in rats with metabolic syndrome

    Uchinaka Ayako, Kawashima Yuri, Sano Yuki, Ito Shogo, Sano Yusuke, Nagasawa Kai, Matsuura Natsumi, Yoneda Mamoru, Yamada Yuichiro, Murohara Toyoaki, Nagata Kohzo

    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES   Vol. 1421 ( 1 ) page: 73 - 87   2018.6

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    DOI: 10.1111/nyas.13578

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  92. Anti-inflammatory effects of heat-killed Lactobacillus plantarum L-137 on cardiac and adipose tissue in rats with metabolic syndrome

    Uchinaka Ayako, Azuma Naoki, Mizumoto Hisashi, Nakano Shiho, Minamiya Moeko, Yoneda Mamoru, Aoyama Kiyoshi, Komatsu Yuki, Yamada Yuichiro, Murohara Toyoaki, Nagata Kohzo

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 8156   2018.5

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    DOI: 10.1038/s41598-018-26588-x

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  93. Left ventricular end-diastolic dimension and septal e' are predictors of cardiac index at rest, while tricuspid annular plane systolic excursion is a predictor of peak oxygen uptake in patients with pulmonary hypertension.

    Nakano Y, Okumura N, Adachi S, Shimokata S, Tajima F, Kamimura Y, Murohara T, Kondo T

    Heart and vessels   Vol. 33 ( 5 ) page: 521 - 528   2018.5

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    DOI: 10.1007/s00380-017-1086-0

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  94. Left ventricular hypertrophy and proteinuria in patients with essential hypertension in Andkhoy, Afghanistan.

    Shoaib Hamrah M, Hassan Hamrah M, Ishii H, Suzuki S, Hussain Hamrah M, Edris Hamrah A, Elias Dahi A, Yisireyili M, Kano N, Takeshita K, Hashem Hamrah M, Sakamoto J, Murohara T

    Nagoya journal of medical science   Vol. 80 ( 2 ) page: 249-255   2018.5

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    DOI: 10.18999/nagjms.80.2.249

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  95. Uninterrupted Direct Oral Anticoagulant and Warfarin Administration in Elderly Patients Undergoing Catheter Ablation for Atrial Fibrillation: A Comparison With Younger Patients.

    Yanagisawa S, Inden Y, Fujii A, Ando M, Funabiki J, Murase Y, Takenaka M, Otake N, Ikai Y, Sakamoto Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   Vol. 4 ( 5 ) page: 592 - 600   2018.5

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    DOI: 10.1016/j.jacep.2018.02.013

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  96. Announcement of the 2018 JCS Meeting Activities (2).

    Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 82 ( 5 ) page: 1219-1221   2018.4

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    DOI: 10.1253/circj.CJ-66-0152

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  97. Association between Helicobacter pylori Infection and Cardiovascular Risk Factors among Patients in the Northern Part of Afghanistan: a Cross-Sectional Study in Andkhoy City

    Hamrah MS, Hamrah MH, Ishii H, Suzuki S, Hamrah MH, Hamrah AE, Dahi AE, Takeshita K, Hamrah MH, Fotouhi A, Sakamoto J, Murohara T

    Asian Pacific journal of cancer prevention : APJCP   Vol. 19 ( 4 ) page: 1035-1039   2018.4

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    DOI: 10.22034/APJCP.2018.19.4.1035

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  98. Ultrasonographic and radiological imaging demonstrating an anomalous origin of the left coronary artery causing acute coronary syndrome in an adolescent.

    Taniguchi T, Umemoto N, Ishii H, Nakahata K, Shibata N, Mizutani T, Yamada M, Shimizu K, Murohara T

    Journal of cardiology cases   Vol. 17 ( 4 ) page: 141-145   2018.4

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    DOI: 10.1016/j.jccase.2017.12.008

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  99. Rapid Publication and Announcement of the 2018 JCS Meeting Activities.

    Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 82 ( 4 ) page: 935-936   2018.3

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    DOI: 10.1253/circj.CJ-66-0151

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  100. Skeletal Muscle Pump Function Is Associated With Exercise Capacity in Patients With Heart Failure.

    Kondo T, Yamada S, Asai C, Okumura T, Tanimura D, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society     2018.3

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    DOI: 10.1253/circj.CJ-17-0927

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  101. Balance between angiogenic and anti-angiogenic isoforms of VEGF-A is associated with the complexity and severity of coronary artery disease

    Shibata Yohei, Kikuchi Ryosuke, Ishii Hideki, Suzuki Susumu, Harada Kazuhiro, Hirayama Kenshi, Suzuki Atsuo, Tatami Yosuke, Kondo Kazuhisa, Murohara Toyoaki

    CLINICA CHIMICA ACTA   Vol. 478   page: 114 - 119   2018.3

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    DOI: 10.1016/j.cca.2017.12.042

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  102. Renal function and risk of stroke and bleeding in patients undergoing catheter ablation for atrial fibrillation: Comparison between uninterrupted direct oral anticoagulants and warfarin administration.

    Yanagisawa S, Inden Y, Fujii A, Ando M, Funabiki J, Murase Y, Takenaka M, Otake N, Ikai Y, Sakamoto Y, Shibata R, Murohara T

    Heart rhythm   Vol. 15 ( 3 ) page: 348-354   2018.3

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    DOI: 10.1016/j.hrthm.2017.10.033

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  103. Early Prediction Model for Successful Bridge to Recovery in Patients With Fulminant Myocarditis Supported With Percutaneous Venoarterial Extracorporeal Membrane Oxygenation - Insights From the CHANGE PUMP Study.

      Vol. 82 ( 3 ) page: 699-707   2018.2

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    DOI: 10.1253/circj.CJ-17-0549

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  104. Effects of Ezetimibe-Statin Combination Therapy on Coronary Atherosclerosis in Acute Coronary Syndrome.

    Hibi K, Sonoda S, Kawasaki M, Otsuji Y, Murohara T, Ishii H, Sato K, Koshida R, Ozaki Y, Sata M, Morino Y, Miyamoto T, Amano T, Morita S, Kozuma K, Kimura K, Fujiwara H, Ezetimibe-ACS Investigators.

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 82 ( 3 ) page: 757-766   2018.2

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    DOI: 10.1253/circj.CJ-17-0598

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  105. Impact of high-density lipoprotein 3 cholesterol subfraction on periprocedural myocardial injury in patients who underwent elective percutaneous coronary intervention

    Harada Kazuhiro, Kikuchi Ryosuke, Suzuki Susumu, Tanaka Akihito, Aoki Toshijiro, Iwakawa Naoki, Kojima Hiroki, Hirayama Kenshi, Mitsuda Takayuki, Sumi Takuya, Negishi Yosuke, Ishii Hideki, Murohara Toyoaki

    LIPIDS IN HEALTH AND DISEASE   Vol. 17 ( 1 ) page: 21   2018.2

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    DOI: 10.1186/s12944-018-0670-3

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  106. Clinical Characteristics of Nonobese Patients with Acute Coronary Syndrome and Increased Epicardial Fat Volume.

    Harada K, Suzuki H, Matsunaga S, Onishi T, Nishikawa Y, Funakubo H, Mamiya K, Nagao T, Shinoda N, Sakai S, Kato M, Marui N, Ishii H, Amano T, Matsubara T, Murohara T

    Journal of atherosclerosis and thrombosis     2018.2

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    DOI: 10.5551/jat.42663

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  107. Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction

    Tian Zhe, Miyata Keishi, Morinaga Jun, Horiguchi Haruki, Kadomatsu Tsuyoshi, Endo Motoyoshi, Zhao Jiabin, Zhu Shunshun, Sugizaki Taichi, Sato Michio, Terada Kazutoyo, Okumura Takahiro, Murohara Toyoaki, Oike Yuichi

    CIRCULATION JOURNAL   Vol. 82 ( 2 ) page: 437-+   2018.2

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    DOI: 10.1253/circj.CJ-17-0327

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  108. Head-to-head comparison of acute and chronic pulmonary vein stenosis for cryoballoon versus radiofrequency ablation.

    Watanabe R, Sairaku A, Yoshida Y, Nanasato M, Kamiya H, Suzuki H, Ogura Y, Aoyama Y, Maeda M, Ando M, Eguchi S, Inden Y, Kihara Y, Murohara T

    Pacing and clinical electrophysiology : PACE     2018.1

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    DOI: 10.1111/pace.13293

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  109. Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan.

    Kondo K, Yanishi K, Hayashida R, Shintani S, Shibata R, Murotani K, Ando M, Mizuno M, Fujiwara T, Murohara T, Matoba S, TACT Follow-up Study Investigators.

    Circulation journal : official journal of the Japanese Circulation Society     2018.1

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    DOI: 10.1253/circj.CJ-17-0510

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  110. Clinical Outcomes after Isolated Infrapopliteal Revascularization in Hemodialysis Patients with Critical Limb Ischemia: Endovascular Therapy versus Bypass Surgery.

    Ito R, Kumada Y, Ishii H, Kamoi D, Sakakibara T, Umemoto N, Takahashi H, Murohara T

    Journal of atherosclerosis and thrombosis     2018.1

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    DOI: 10.5551/jat.42648

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  111. Coronary air embolism following transbronchial lung biopsy.

    Sumi T, Tanaka A, Ishii H, Suzuki S, Kada K, Murohara T

    Cardiovascular intervention and therapeutics     2018.1

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    DOI: 10.1007/s12928-017-0508-3

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  112. Use of sodium-glucose cotransporter 2 inhibitors in older patients with type 2 diabetes mellitus.

    Kambara T, Shibata R, Osanai H, Nakashima Y, Asano H, Sakai K, Murohara T, Ajioka M

    Geriatrics & gerontology international   Vol. 18 ( 1 ) page: 108-114   2018.1

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    DOI: 10.1111/ggi.13149

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  113. Double-Blind, Randomized, Placebo-Controlled Trial Evaluating the Efficacy and Safety of Eplerenone in Japanese Patients With Chronic Heart Failure (J-EMPHASIS-HF)

    Tsutsui Hiroyuki, Ito Hiroshi, Kitakaze Masafumi, Komuro Issei, Murohara Toyoaki, Izumi Tohru, Sunagawa Kenji, Yasumura Yoshio, Yano Masafumi, Yamamoto Kazuhiro, Yoshikawa Tsutomu, Tsutamoto Takayoshi, Zhang Junwei, Okayama Akifumi, Ichikawa Yoshihiko, Kanmuri Kazuhiro, Matsuzaki Masunori

    CIRCULATION JOURNAL   Vol. 82 ( 1 ) page: 148-+   2018.1

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    DOI: 10.1253/circj.CJ-17-0323

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  114. Assessment of autonomic nervous system modulation after novel catheter ablation techniques for atrial fibrillation using multiple short-term electrocardiogram recordings

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Ikai Yoshihiro, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 51 ( 1 ) page: 35 - 44   2018.1

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    DOI: 10.1007/s10840-017-0295-x

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  115. Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice

    Takemoto Yoshio, Horiba Mitsuru, Harada Masahide, Sakamoto Kazuma, Takeshita Kyosuke, Murohara Toyoaki, Kadomatsu Kenji, Kamiya Kaichiro

    CIRCULATION JOURNAL   Vol. 82 ( 1 ) page: 19-27   2018.1

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    DOI: 10.1253/circj.CJ-17-0043

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  116. The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy.

    Hiraiwa H, Okumura T, Sawamura A, Sugiura Y, Kondo T, Watanabe N, Aoki S, Ichii T, Kitagawa K, Kano N, Fukaya K, Furusawa K, Morimoto R, Takeshita K, Bando YK, Murohara T

    Journal of cardiology   Vol. 71 ( 3-4 ) page: 284 - 290   2018

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    DOI: 10.1016/j.jjcc.2017.09.002

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  117. Anxiety and Depression among Hypertensive Outpatients in Afghanistan: A Cross-Sectional Study in Andkhoy City.

    Hamrah MS, Hamrah MH, Ishii H, Suzuki S, Hamrah MH, Hamrah AE, Dahi AE, Takeshita K, Yisireyili M, Hamrah MH, Fotouhi A, Sakamoto J, Murohara T

    International journal of hypertension   Vol. 2018   page: 8560835   2018

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    DOI: 10.1155/2018/8560835

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  118. The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy reply

    Hiraiwa Hiroaki, Okumura Takahiro, Sawamura Akinori, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 72 ( 3-4 ) page: 266 - 266   2018

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    DOI: 10.1016/j.jjcc.2018.02.005

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  119. Urinary and circulating levels of the anti-angiogenic isoform of vascular endothelial growth factor-A in patients with chronic kidney disease

    Kikuchi Ryosuke, Yasuda Yoshinari, Nakatochi Masahiro, Shibata Yohei, Hara Toshiaki, Suzuki Atsuo, Imaizumi Takahiro, Suzuki Susumu, Ishii Hideki, Takeshita Kyosuke, Matsushita Tadashi, Maruyama Shoichi, Murohara Toyoaki

    CLINICA CHIMICA ACTA   Vol. 475   page: 102 - 108   2017.12

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    DOI: 10.1016/j.cca.2017.10.014

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  120. The combination assessment of lipid pool and thrombus by optical coherence tomography can predict the filter no-reflow in primary PCI for ST elevated myocardial infarction

    Negishi Yosuke, Ishii Hideki, Suzuki Susumu, Aoki Toshijiro, Iwakawa Naoki, Kojima Hiroki, Harada Kazuhiro, Hirayama Kenshi, Mitsuda Takayuki, Sumi Takuya, Tanaka Akihito, Ogawa Yasuhiro, Kawaguchi Katsuhiro, Murohara Toyoaki

    MEDICINE   Vol. 96 ( 50 ) page: e9297   2017.12

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    DOI: 10.1097/MD.0000000000009297

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  121. Development and Validation of a Novel Cuff-Less Blood Pressure Monitoring Device.

      Vol. 2 ( 6 ) page: 631-642   2017.12

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    DOI: 10.1016/j.jacbts.2017.07.015

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  122. Impact of post-dilatation on longitudinal stent elongation: An in vitro study.

    Sumi T, Ishii H, Tanaka A, Suzuki S, Kojima H, Iwakawa N, Aoki T, Hirayama K, Mitsuda T, Harada K, Negishi Y, Ota T, Kada K, Murohara T

    Journal of cardiology     2017.11

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    DOI: 10.1016/j.jjcc.2017.11.003

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  123. Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice.

    Yisireyili M, Uchida Y, Yamamoto K, Nakayama T, Cheng XW, Matsushita T, Nakamura S, Murohara T, Takeshita K

    Brain, behavior, and immunity     2017.11

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    DOI: 10.1016/j.bbi.2017.11.010

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  124. Impact of Coronary Stent Fracture on Restenotic Neointimal Tissue Characterization After Drug-Eluting Stent Implantation An Integrated Backscatter Intravascular Ultrasound Study

    Uchida Yasuhiro, Ichimiya Satoshi, Ishii Hideki, Oishi Hideo, Aoki Toshijiro, Miki Yusuke, Kawamiya Toshiki, Ichimiya Hitoshi, Watanabe Junji, Kanashiro Masaaki, Hayano Shinji, Suzuki Susumu, Amano Tetsuya, Matsubara Tatsuaki, Murohara Toyoaki

    INTERNATIONAL HEART JOURNAL   Vol. 58 ( 6 ) page: 861-867   2017.11

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    DOI: 10.1536/ihj.16-571

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  125. Safety and Efficacy of Long-Term Use of Tolvaptan in Patients With Heart Failure and Chronic Kidney Disease

    Uemura Yusuke, Shibata Rei, Takemoto Kenji, Uchikawa Tomohiro, Koyasu Masayoshi, Ishikawa Shinji, Imai Ryo, Ozaki Yuta, Watanabe Takashi, Teraoka Tsubasa, Watarai Masato, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 81 ( 11 ) page: 1736-+   2017.11

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    DOI: 10.1253/circj.CJ-17-0554

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  126. Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells

    Yisireyili Maimaiti, Takeshita Kyosuke, Saito Shinichi, Murohara Toyoaki, Niwa Toshimitsu

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 4 ) page: 477-486   2017.11

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    DOI: 10.18999/nagjms.79.4.477

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  127. Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia-Induced Neovascularization: The Role of Dipeptidyl Peptidase-4/Glucagon-Like Peptide-1-Adiponectin Axis

    Piao Limei, Zhao Guangxian, Zhu Enbo, Inoue Aiko, Shibata Rei, Lei Yanna, Hu Lina, Yu Chenglin, Yang Guang, Wu Hongxian, Xu Wenhu, Okumura Kenji, Ouchi Noriyuki, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 6 ( 10 )   2017.10

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    DOI: 10.1161/JAHA.117.006421

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  128. Lipid-Lowering Therapy With Monoclonal Antibodies to Proprotein Convertase Subtilisin-Kexin Type 9. Lessons From Recent Clinical Trials

    Ishii Hideki, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 81 ( 10 ) page: 1386 - 1387   2017.10

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    DOI: 10.1253/circj.CJ-17-0511

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  129. Vasospastic angina in a 16-year-old female.

    Sumi T, Tanaka A, Ishii H, Suzuki S, Oguri M, Murohara T

    Cardiovascular intervention and therapeutics     2017.9

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    DOI: 10.1007/s12928-017-0489-2

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  130. Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension

    Tanabe Nobuhiro, Ikeda Satoshi, Tahara Nobuhiro, Fukuda Keiichi, Hatano Masaru, Ito Hiroshi, Nakayama Tomotaka, Anzai Toshihisa, Hashimoto Akiyoshi, Inoue Teruo, Kajinami Kouji, Kihara Yasuki, Kinoshita Hideyuki, Kuwahara Koichiro, Murohara Toyoaki, Okazaki Osamu, Sakai Satoshi, Satoh Toru, Takeda Yutaka, Takeishi Yasuchika, Taniguchi Mitsugu, Watanabe Hiroshi, Yamamoto Takeshi, Yamauchi-Takihara Keiko, Yoshioka Koichiro, Sasayama Shigetake

    CIRCULATION JOURNAL   Vol. 81 ( 9 ) page: 1360-1367   2017.9

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    DOI: 10.1253/circj.CJ-16-1348

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  131. Different rate-dependent responses between J waves and the notches on an epicardial local electrogram in a patient with idiopathic ventricular fibrillation.

    Kamikubo Y, Inden Y, Nagao T, Aizawa Y, Murohara T

    HeartRhythm case reports   Vol. 3 ( 9 ) page: 427-430   2017.9

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    DOI: 10.1016/j.hrcr.2017.06.010

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  132. Sokolow-Lyon voltage is suitable for monitoring improvement in cardiac function and prognosis of patients with idiopathic dilated cardiomyopathy

    Fukaya Kenji, Takeshita Kyosuke, Okumura Takahiro, Hiraiwa Hiroaki, Aoki Soichiro, Ichii Takeo, Sugiura Yuki, Kitagawa Katsuhide, Kondo Toru, Watanabe Naoki, Kano Naoaki, Furusawa Kenji, Sawamura Akinori, Morimoto Ryota, Bando Yasuko, Murohara Toyoaki

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   Vol. 22 ( 5 )   2017.9

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    DOI: 10.1111/anec.12431

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  133. Dynamics of angiogenesis in ischemic areas of the infarcted heart

    Kobayashi Koichi, Maeda Kengo, Takefuji Mikito, Kikuchi Ryosuke, Morishita Yoshihiro, Hirashima Masanori, Murohara Toyoaki

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 7156   2017.8

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    DOI: 10.1038/s41598-017-07524-x

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  134. Atorvastatin reduces cardiac and adipose tissue inflammation in rats with metabolic syndrome

    Yamada Yuichiro, Takeuchi Shino, Yoneda Mamoru, Ito Shogo, Sano Yusuke, Nagasawa Kai, Matsuura Natsumi, Uchinaka Ayako, Murohara Toyoaki, Nagata Kohzo

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 240   page: 332 - 338   2017.8

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    DOI: 10.1016/j.ijcard.2017.04.103

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  135. Vagal response in cryoballoon ablation of atrial fibrillation and autonomic nervous system: Utility of epicardial adipose tissue location

    Yanagisawa Satoshi, Inden Yasuya, Mizutani Yoshiaki, Fujii Aya, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Hattori Tetsuyoshi, Shibata Rei, Murohara Toyoaki

    JOURNAL OF ARRHYTHMIA   Vol. 33 ( 4 ) page: 275 - 282   2017.8

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    DOI: 10.1016/j.joa.2017.03.001

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  136. Effects of mTOR inhibition on cardiac and adipose tissue pathology and glucose metabolism in rats with metabolic syndrome

    Uchinaka Ayako, Yoneda Mamoru, Yamada Yuichiro, Murohara Toyoaki, Nagata Kohzo

    PHARMACOLOGY RESEARCH & PERSPECTIVES   Vol. 5 ( 4 )   2017.8

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    DOI: 10.1002/prp2.331

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  137. Does Treatment of Impaired Glucose Tolerance Improve Cardiovascular Outcomes in Patients with Previous Myocardial Infarction?

    Asakura Masanori, Kim Jiyoong, Asanuma Hiroshi, Hamasaki Toshimitsu, Tsukahara Kengo, Higashino Yorihiko, Ishikawa Tetsuya, Nakama Yasuharu, Koba Shinji, Maruyama Yasuyuki, Tsujimoto Mitsuru, Himeno Hideo, Ohkusa Takanori, Fujino Susumu, Shimizu Makoto, Endo Tsutomu, Yoda Shunichi, Muroya Takahiro, Murohara Toyoaki, Ohte Nobuyuki, Suzuki Hiroshi, Kohno Tohru, Fukui Kazuki, Shiono Takaaki, Takase Hiroyuki, Uzui Hiroyasu, Nagai Yoshiyuki, Hashimoto Yuji, Ikeda Shuntaro, Mizuno Sumio, Tamita Koichi, Fujita Masashi, Satake Kazuo, Kinoshita Yoshihiko, Nunohiro Tatsuya, Sakagami Satoru, Higaki Jitsuo, Morii Isao, Sawada Reimin, Hiasa Yoshikazu, Shigemasa Tomohiko, Nakahama Makoto, Sata Masataka, Doi Osamu, Ueda Tetsuro, Yamada Takahisa, Yamanouchi Takayoshi, Yamaguchi Hajime, Morita Yukiko, Hayashi Hideki, Kitakaze Masafumi

    CARDIOVASCULAR DRUGS AND THERAPY   Vol. 31 ( 4 ) page: 401-411   2017.8

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    DOI: 10.1007/s10557-017-6740-3

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  138. Impact of drug-coated balloon in hemodialysis patients with in-stent-restenosis lesion

    Umemoto N., Ishii H., Kamoi D., Sakakibara T., Aoyama T., Kitahara Y., Takahashi H., Murohara T.

    EUROPEAN HEART JOURNAL   Vol. 38   page: 86-86   2017.8

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  139. Predictive value of abdominal aortic calcification index for the mid-term cardiovascular events among patients with acute coronary syndrome

    Horibe H., Oishi H., Yamase Y., Ueyama C., Ikehara N., Akita N., Shigeta T., Yajima K., Hibino T., Kondo T., Kawamiya T., Suzuki S., Ishii H., Murohara T.

    EUROPEAN HEART JOURNAL   Vol. 38   page: 130-131   2017.8

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  140. Correlations between geriatric nutritional risk index and peripheral artery disease in elderly coronary artery disease patients

    Kawamiya Toshiki, Suzuki Susumu, Ishii Hideki, Hirayama Kenshi, Harada Kazuhiro, Shibata Yohei, Tatami Yosuke, Harata Shingo, Kawashima Kazuhiro, Kunimura Ayako, Takayama Yohei, Shimbo Yusaku, Osugi Naohiro, Yamamoto Dai, Ota Tomoyuki, Kono Chikao, Murohara Toyoaki

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 17 ( 7 ) page: 1057-1062   2017.7

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    DOI: 10.1111/ggi.12828

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  141. Dipeptidyl Peptidase-4 Regulates Hematopoietic Stem Cell Activation in Response to Chronic Stress

    Zhu Enbo, Hu Lina, Wu Hongxian, Piao Limei, Zhao Guangxian, Inoue Aiko, Kim Weon, Yu Chenglin, Xu Wenhu, Bando Yasuko K., Li Xiang, Lei Yanna, Hao Chang-Ning, Takeshita Kyosuke, Kim Woo-Shik, Okumura Kenji, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

    JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 6 ( 7 )   2017.7

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    DOI: 10.1161/JAHA.117.006394

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  142. Decreased Serum Albumin Predicts Bleeding Events in Patients on Antiplatelet Therapy After Percutaneous Coronary Intervention

    Tatami Yosuke, Ishii Hideki, Aoki Toshijiro, Harada Kazuhiro, Hirayama Kenshi, Shibata Yohei, Sumi Takuya, Negishi Yosuke, Kawashima Kazuhiro, Kunimura Ayako, Kawamiya Toshiki, Yamamoto Dai, Suzuki Susumu, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 81 ( 7 ) page: 999 - 1005   2017.7

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    DOI: 10.1253/circj.CJ-17-0015

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  143. Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction

    Tsuda Takuma, Takefuji Mikito, Wettschureck Nina, Kotani Kazuhiko, Morimoto Ryota, Okumura Takahiro, Kaur Harmandeep, Eguchi Shunsuke, Sakaguchi Teruhiro, Ishihama Sohta, Kikuchi Ryosuke, Unno Kazumasa, Matsushita Kunihiro, Ishikawa Shizukiyo, Offermanns Stefan, Murohara Toyoaki

    JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 214 ( 7 ) page: 1877-1888   2017.7

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    DOI: 10.1084/jem.20161924

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  144. Role of Adipokines in Cardiovascular Disease

    Lau Wayne Bond, Ohashi Koji, Wang Yajing, Ogawa Hayato, Murohara Toyoaki, Ma Xin-Liang, Ouchi Noriyuki

    CIRCULATION JOURNAL   Vol. 81 ( 7 ) page: 920-928   2017.7

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    DOI: 10.1253/circj.CJ-17-0458

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  145. Usefulness of the Combination of In-Hospital Poor Diuretic Response and Systemic Congestion to Predict Future Cardiac Events in Patients With Acute Decompensated Heart Failure

    Aoki Soichiro, Okumura Takahiro, Sawamura Akinori, Kitagawa Katsuhide, Morimoto Ryota, Sakakibara Masaki, Murohara Toyoaki

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 119 ( 12 ) page: 2010-2016   2017.6

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    DOI: 10.1016/j.amjcard.2017.03.030

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  146. Comparison of Frequency and Characteristics of Patients With Atrial Fibrillation Having Ablation With Versus Without Coronary Narrowing (>= 50%) by Angiography

    Tomomatsu Toshiro, Morishima Itsuro, Okumura Kenji, Tsuboi Hideyuki, Morita Yasuhiro, Takagi Kensuke, Yoshida Ruka, Nagai Hiroaki, Ikai Yoshihiro, Shibata Naoki, Tsuzuki Kazuhito, Sone Takahito, Murohara Toyoaki

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 119 ( 11 ) page: 1770-1775   2017.6

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    DOI: 10.1016/j.amjcard.2017.02.047

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  147. Coronary artery calcification scores improve contrast-induced nephropathy risk assessment in chronic kidney disease patients

    Osugi Naohiro, Suzuki Susumu, Shibata Yohei, Tatami Yosuke, Harata Shingo, Ota Tomoyuki, Hayashi Mutsuharu, Yasuda Yoshinari, Ishii Hideki, Shimizu Atsuya, Murohara Toyoaki

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 21 ( 3 ) page: 391-397   2017.6

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    DOI: 10.1007/s10157-016-1298-0

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  148. Diallyl Trisulfide Augments Ischemia-Induced Angiogenesis via an Endothelial Nitric Oxide Synthase-Dependent Mechanism

    Hayashida Ryo, Kondo Kazuhisa, Morita Sumio, Unno Kazumasa, Shintani Satoshi, Shimizu Yuuki, Calvert John W., Shibata Rei, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 81 ( 6 ) page: 870-878   2017.6

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    DOI: 10.1253/circj.CJ-16-1097

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  149. Novel therapy for pancreatic fistula using adipose-derived stem cell sheets treated with mannose

    Kaneko Hirokazu, Kokuryo Toshio, Yokoyama Yukihiro, Yamaguchi Junpei, Yamamoto Tokunori, Shibata Rei, Gotoh Momokazu, Murohara Toyoaki, Ito Akira

    SURGERY   Vol. 161 ( 6 ) page: 1561-1569   2017.6

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    DOI: 10.1016/j.surg.2016.12.022

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  150. New diagnostic index for sarcopenia in patients with cardiovascular diseases

    Harada Haruhito, Kai Hisashi, Shibata Rei, Niiyama Hiroshi, Nishiyama Yasuhiro, Murohara Toyoaki, Yoshida Noriko, Katoh Atsushi, Ikeda Hisao

    PLOS ONE   Vol. 12 ( 5 ) page: e0178123   2017.5

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    DOI: 10.1371/journal.pone.0178123

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  151. Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup analysis of the PROLOGUE study

    Yamada Hirotsugu, Tanaka Atsushi, Kusunose Kenya, Amano Rie, Matsuhisa Munehide, Daida Hiroyuki, Ito Masaaki, Tsutsui Hiroyuki, Nanasato Mamoru, Kamiya Haruo, Bando Yasuko K., Odawara Masato, Yoshida Hisako, Murohara Toyoaki, Sata Masataka, Node Koichi

    CARDIOVASCULAR DIABETOLOGY   Vol. 16 ( 1 ) page: 63   2017.5

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    DOI: 10.1186/s12933-017-0546-2

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  152. Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice

    Yisireyili Maimaiti, Hayashi Motoharu, Wu Hongxian, Uchida Yasuhiro, Yamamoto Koji, Kikuchi Ryosuke, Hamrah Mohammad Shoaib, Nakayama Takayuki, Cheng Xian Wu, Matsushita Tadashi, Nakamura Shigeo, Niwa Toshimitsu, Murohara Toyoaki, Takeshita Kyosuke

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 1266   2017.4

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    DOI: 10.1038/s41598-017-01366-3

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  153. Impact of Skeletal Muscle Mass on Long-Term Adverse Cardiovascular Outcomes in Patients With Chronic Kidney Disease

    Harada Kazuhiro, Suzuki Susumu, Ishii Hideki, Aoki Toshijiro, Hirayama Kenshi, Shibata Yohei, Negishi Yosuke, Sumi Takuya, Kawashima Kazuhiro, Kunimura Ayako, Shimbo Yusaku, Tatami Yosuke, Kawamiya Toshiki, Yamamoto Dai, Morimoto Ryota, Yasuda Yoshinari, Murohara Toyoaki

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 119 ( 8 ) page: 1275-1280   2017.4

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    DOI: 10.1016/j.amjcard.2017.01.003

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  154. O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

    Sawaguchi Shogo, Varshney Shweta, Ogawa Mitsutaka, Sakaidani Yuta, Yagi Hirokazu, Takeshita Kyosuke, Murohara Toyoaki, Kato Koichi, Sundaram Subha, Stanley Pamela, Okajima Tetsuya

    ELIFE   Vol. 6   2017.4

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    DOI: 10.7554/eLife.24419

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  155. Impact of basal inferolateral scar burden determined by automatic analysis of Tc-99m-MIBI myocardial perfusion SPECT on the long-term prognosis of cardiac resynchronization therapy

    Morishima Itsuro, Okumura Kenji, Tsuboi Hideyuki, Morita Yasuhiro, Takagi Kensuke, Yoshida Ruka, Nagai Hiroaki, Tomomatsu Toshiro, Ikai Yoshihiro, Terada Kazushi, Sone Takahito, Murohara Toyoaki

    EUROPACE   Vol. 19 ( 4 ) page: 573-579   2017.4

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    DOI: 10.1093/europace/euw068

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  156. Trends in physiological coagulation factors in Japanese patients receiving novel oral anticoagulants

    Nagao Tomoyuki, Hunakubo Hiroshi, Suzuki Mayu, Kataok Takashi, Okumura Satoshi, Shinoda Norihiro, Harada Ken, Kato Bunichi, Kato Masataka, Marui Nobuyuki, Sakai Shinichi, Amano Tetsuya, Murohara Toyoaki

    JOURNAL OF ARRHYTHMIA   Vol. 33 ( 2 ) page: 117-121   2017.4

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    DOI: 10.1016/j.joa.2016.07.011

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  157. The Association of Ankle Brachial Index, Protein-Energy Wasting, and Inflammation Status with Cardiovascular Mortality in Patients on Chronic Hemodialysis

    Ishii Hideki, Takahashi Hiroshi, Ito Yasuhiko, Aoyama Toru, Kamoi Daisuke, Sakakibara Takashi, Umemoto Norio, Kumada Yoshitaka, Suzuki Susumu, Murohara Toyoaki

    NUTRIENTS   Vol. 9 ( 4 )   2017.4

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    DOI: 10.3390/nu9040416

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  158. Impact of nutritional assessment and body mass index on cardiovascular outcomes in patients with stable coronary artery disease

    Kunimura Ayako, Ishii Hideki, Uetani Tadayuki, Aoki Toshijirou, Harada Kazuhiro, Hirayama Kenshi, Negishi Yosuke, Shibata Yohei, Sumi Takuya, Kawashima Kazuhiro, Tatami Yosuke, Kawamiya Toshiki, Yamamoto Dai, Suzuki Susumu, Amano Tetsuya, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 230   page: 653-658   2017.3

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    DOI: 10.1016/j.ijcard.2017.01.008

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  159. Increased pre-procedural urinary microalbumin is associated with a risk for renal functional deterioration after coronary computed tomography angiography

    Isobe Satoshi, Yuba Miyuki, Mori Hiroaki, Suzuki Susumu, Sato Kimihide, Ishii Hideki, Murohara Toyoaki

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 230   page: 599-603   2017.3

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    DOI: 10.1016/j.ijcard.2016.12.049

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  160. Assessment of left ventricular diastolic function during trastuzumab treatment in patients with HER2-positive breast cancer

    Honda Kazunori, Takeshita Kyosuke, Murotani Kenta, Mitsuma Ayako, Hayashi Hironori, Tsunoda Nobuyuki, Kikumori Toyone, Murohara Toyoaki, Ando Yuichi

    BREAST CANCER   Vol. 24 ( 2 ) page: 312-318   2017.3

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    DOI: 10.1007/s12282-016-0705-4

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  161. Biphasic Force-Frequency Relation Predicts Primary Cardiac Events in Patients With Hypertrophic Cardiomyopathy

    Morimoto Ryota, Okumura Takahiro, Bando Yasuko K., Fukaya Kenji, Sawamura Akinori, Kawase Haruya, Shimizu Shinya, Shimazu Shuzo, Hirashiki Akihiro, Takeshita Kyosuke, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 81 ( 3 ) page: 368 - 375   2017.3

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    DOI: 10.1253/circj.CJ-16-1007

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  162. Association between plaque characteristics and the amount of debris captured by a filter-type distal protection device in patients with acute coronary syndrome

    Kitagawa Katsuhide, Amano Tetsuya, Uetani Tadayuki, Ishii Hideki, Okumura Takahiro, Suzuki Susumu, Takashima Hiroaki, Kurita Akiyoshi, Ando Hirohiko, Matsubara Tatsuaki, Murohara Toyoaki

    ATHEROSCLEROSIS   Vol. 258   page: 72-78   2017.3

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    DOI: 10.1016/j.atherosclerosis.2017.02.001

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  163. Long-Term Pathological Follow-Up of Myocardium in a Carrier of Duchenne Muscular Dystrophy With Dilated Cardiomyopathy

    Kondo Toru, Okumura Takahiro, Takefuji Mikito, Hiraiwa Hiroaki, Sugiura Yuki, Watanabe Naoki, Aoki Soichiro, Ichii Takeo, Kitagawa Katsuhide, Kano Naoaki, Fukaya Kenji, Furusawa Kenji, Sawamura Akinori, Morimoto Ryota, Bando Yasuko K., Takemura Genzou, Murohara Toyoaki

    CIRCULATION-HEART FAILURE   Vol. 10 ( 3 ) page: e003826   2017.3

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    DOI: 10.1161/CIRCHEARTFAILURE.117.003826

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  164. Nutrition Status Predicts Severity of Vascular Calcification in Non-Dialyzed Chronic Kidney Disease

    Harada Kazuhiro, Suzuki Susumu, Ishii Hideki, Hirayama Kenshi, Aoki Toshijiro, Shibata Yohei, Negishi Yosuke, Sumi Takuya, Kawashima Kazuhiro, Kunimura Ayako, Tatami Yosuke, Kawamiya Toshiki, Yamamoto Dai, Morimoto Ryota, Yasuda Yoshinari, Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 81 ( 3 ) page: 316 - 321   2017.3

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    DOI: 10.1253/circj.CJ-16-0911

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  165. Asian Perspective of the EMPA-REG OUTCOME Study

    Bando Yasuko K., Murohara Toyoaki

    CIRCULATION JOURNAL   Vol. 81 ( 2 ) page: 155 - 157   2017.2

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    DOI: 10.1253/circj.CJ-16-1304

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  166. C1q/TNF-related protein 1 prevents neointimal formation after arterial injury

    Kanemura Noriyoshi, Shibata Rei, Ohashi Koji, Ogawa Hayato, Hiramatsu-Ito Mizuho, Enomoto Takashi, Yuasa Daisuke, Ito Masanori, Hayakawa Satoko, Otaka Naoya, Murohara Toyoaki, Ouchi Noriyuki

    ATHEROSCLEROSIS   Vol. 257   page: 138 - 145   2017.2

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    DOI: 10.1016/j.atherosclerosis.2017.01.014

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  167. Association of renal function with clinical parameters and conditions in a longitudinal population-based epidemiological study

    Sumi Takuya, Oguri Mitsutoshi, Fujimaki Tetsuo, Horibe Hideki, Kato Kimihiko, Matsui Kota, Takeuchi Ichiro, Murohara Toyoaki, Yamada Yoshiji

    BIOMEDICAL REPORTS   Vol. 6 ( 2 ) page: 242-250   2017.2

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    DOI: 10.3892/br.2016.831

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  168. Impact of Paradoxical Decrease in High-density Lipoprotein Cholesterol Levels After Statin Therapy on Major Adverse Cardiovascular Events in Patients with Stable Angina Pectoris

    Hirayama Kenshi, Ota Tomoyuki, Harada Kazuhiro, Shibata Yohei, Tatami Yosuke, Harata Shingo, Kawashima Kazuhiro, Kunimura Ayako, Shimbo Yusaku, Takayama Yohei, Kawamiya Toshiki, Yamamoto Dai, Osugi Naohiro, Suzuki Susumu, Ishii Hideki, Murohara Toyoaki

    CLINICAL THERAPEUTICS   Vol. 39 ( 2 ) page: 279 - 287   2017.2

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    DOI: 10.1016/j.clinthera.2016.12.006

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  169. Non-vitamin K antagonist oral anticoagulants versus warfarin for cardioversion of atrial fibrillation in clinical practice: A single-center experience

    Shibata Naoki, Morishima Itsuro, Okumura Kenji, Morita Yasuhiro, Takagi Kensuke, Yoshida Ruka, Nagai Hiroaki, Tomomatsu Toshiro, Ikai Yoshihiro, Terada Kazushi, Tsuzuki Kazuhito, Tsuboi Hideyuki, Sone Takahito, Murohara Toyoaki

    JOURNAL OF ARRHYTHMIA   Vol. 33 ( 1 ) page: 7-11   2017.2

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    DOI: 10.1016/j.joa.2016.04.003

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  170. Association of contrast-induced nephropathy with risk of adverse clinical outcomes in patients with cardiac catheterization: From the CINC-J study

    Sato Akira, Aonuma Kazutaka, Watanabe Makoto, Hirayama Atsushi, Tamaki Nagara, Tsutsui Hiroyuki, Murohara Toyoaki, Ogawa Hisao, Akasaka Takashi, Yoshimura Michihiro, Takayama Tadateru, Sakakibara Mamoru, Suzuki Susumu, Ishigami Kenichi, Onoue Kenji, Saito Yoshihiko

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 227   page: 424-429   2017.1

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    DOI: 10.1016/j.ijcard.2016.11.019

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  171. Abnormal Circadian Blood Pressure Profile as a Prognostic Marker in Patients with Nonischemic Dilated Cardiomyopathy

    Sawamura Akinori, Okumura Takahiro, Takeshita Kyosuke, Watanabe Naoki, Kano Naoaki, Mori Hiroaki, Fukaya Kenji, Morimoto Ryota, Hirashiki Akihiro, Bando Yasuko Kureishi, Murohara Toyoaki

    CARDIOLOGY   Vol. 136 ( 1 ) page: 1 - 9   2017

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    DOI: 10.1159/000446868

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  172. Effect of Body Mass Index on Posttonsillectomy Hemorrhage

    Hoshino Tetsuro, Tanigawa Tohru, Yanohara Gen, Murotani Kenta, Horibe Yuichiro, Murohara Toyoaki, Shibata Rei, Ueda Hiromi

    BIOMED RESEARCH INTERNATIONAL   Vol. 2017   page: 9610267   2017

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    DOI: 10.1155/2017/9610267

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  173. Early Spontaneous Remission of Intramyocardial Dissecting Hematoma

    Miura Ayako, Uemura Yusuke, Takemoto Kenji, Uchikawa Tomohiro, Koyasu Masayoshi, Ishikawa Shinji, Mitsuda Takayuki, Imai Ryo, Iwamiya Satoshi, Ozaki Yuta, Watanabe Takashi, Watarai Masato, Ishii Hideki, Murohara Toyoaki

    INTERNAL MEDICINE   Vol. 56 ( 9 ) page: 1067-1070   2017

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    DOI: 10.2169/internalmedicine.56.7967

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  174. Circulatory power and ventilatory power over time under goal-oriented sequential combination therapy for pulmonary arterial hypertension

    Hirashiki Akihiro, Adachi Shiro, Nakano Yoshihisa, Kamimura Yoshihiro, Shimokata Shigetake, Takeshita Kyosuke, Shimizu Atsuya, Toba Kenji, Murohara Toyoaki, Kondo Takahisa

    PULMONARY CIRCULATION   Vol. 7 ( 2 ) page: 448-454   2017

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    DOI: 10.1177/2045893217703954

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  175. Cholesterol metabolism as a prognostic marker in patients with mildly symptomatic nonischemic dilated cardiomyopathy

    Sawamura Akinori, Okumura Takahiro, Hiraiwa Hiroaki, Aoki Soichiro, Kondo Toru, Ichii Takeo, Furusawa Kenji, Watanabe Naoki, Kano Naoaki, Fukaya Kenji, Morimoto Ryota, Bando Yasuko K., Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 69 ( 5-6 ) page: 888 - 894   2017

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    DOI: 10.1016/j.jjcc.2016.08.012

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  176. Impact of Geriatric Nutritional Risk Index on cardiovascular outcomes in patients with stable coronary artery disease

    Kunimura Ayako, Ishii Hideki, Uetani Tadayuki, Aoki Toshijirou, Harada Kazuhiro, Hirayama Kenshi, Negishi Yosuke, Shibata Yohei, Sumi Takuya, Kawashima Kazuhiro, Tatami Yosuke, Kawamiya Toshiki, Yamamoto Dai, Suzuki Susumu, Amano Tetsuya, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 69 ( 1-2 ) page: 383-388   2017

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    DOI: 10.1016/j.jjcc.2016.09.004

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  177. The role of adipokines in cardiovascular disease

    Shibata Rei, Ouchi Noriyuki, Ohashi Koji, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 70 ( 3-4 ) page: 329 - 334   2017

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    DOI: 10.1016/j.jjcc.2017.02.006

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  178. Relationship between pre-procedural microalbuminuria and renal functional changes after coronary computed tomography in diabetic patients

    Isobe Satoshi, Yamada Takashi, Yuba Miyuki, Hayashi Mutsuharu, Ishii Hideki, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 69 ( 3-4 ) page: 666-670   2017

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    DOI: 10.1016/j.jjcc.2016.06.005

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  179. Predictive Value of Aortic Valve Calcification for Periprocedural Myocardial Injury in Patients Undergoing Percutaneous Coronary Intervention

    Shibata Yohei, Ishii Hideki, Suzuki Susumu, Tanaka Akihito, Tatami Yosuke, Harata Shingo, Ota Tomoyuki, Shimbo Yusaku, Takayama Yohei, Kunimura Ayako, Hirayama Kenshi, Harada Kazuhiro, Osugi Naohiro, Murohara Toyoaki

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   Vol. 24 ( 5 ) page: 487 - 494   2017

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    DOI: 10.5551/jat.36582

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  180. Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy

    Morimoto Ryota, Okumura Takahiro, Hirashiki Akihiro, Ishii Hideki, Ichii Takeo, Aoki Soichiro, Furusawa Kenji, Hiraiwa Hiroaki, Kondo Toru, Watanabe Naoki, Kano Naoaki, Fukaya Kenji, Sawamura Akinori, Takeshita Kyosuke, Bando Yasuko K., Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 70 ( 3-4 ) page: 303 - 309   2017

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    DOI: 10.1016/j.jjcc.2017.02.005

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  181. Monitoring of anti-Xa activity and factors related to bleeding events: A study in Japanese patients with nonvalvular atrial fibrillation receiving rivaroxaban

    Sakaguchi Teruhiro, Osanai Hiroyuki, Murase Yosuke, Ishii Hideki, Nakashima Yoshihito, Asano Hiroshi, Suzuki Susumu, Takefuji Mikito, Inden Yasuya, Sakai Kazuyoshi, Murohara Toyoaki, Ajioka Masayoshi

    JOURNAL OF CARDIOLOGY   Vol. 70 ( 3-4 ) page: 244-249   2017

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    DOI: 10.1016/j.jjcc.2016.11.013

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  182. Left main coronary artery compression by a dilated main pulmonary artery and left coronary sinus of Valsalva aneurysm in a patient with heritable pulmonary arterial hypertension and FLNA mutation

    Hirashiki Akihiro, Adachi Shiro, Nakano Yoshihisa, Kamimura Yoshihiro, Ogo Takeshi, Nakanishi Norifumi, Morisaki Takayuki, Morisaki Hiroko, Shimizu Atsuya, Toba Kenji, Murohara Toyoaki, Kondo Takahisa

    PULMONARY CIRCULATION   Vol. 7 ( 3 ) page: 734-740   2017

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    DOI: 10.1177/2045893217716107

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  183. Influence of False Lumen Status on the Prognosis of Acute Type A Aortic Dissection without Urgent Surgical Treatment

    Tanaka Akihito, Ishii Hideki, Suzuki Susumu, Ota Tomoyuki, Oshima Hideki, Usui Akihiko, Komori Kimihiro, Murohara Toyoaki

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   Vol. 24 ( 2 ) page: 169 - 175   2017

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    DOI: 10.5551/jat.35675

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  184. Impaired renal function is associated with recurrence after cryoballoon catheter ablation for paroxysmal atrial fibrillation: A potential effect of non-pulmonary vein foci

    Yanagisawa Satoshi, Inden Yasuya, Kato Hiroyuki, Fujii Aya, Mizutani Yoshiaki, Ito Tadahiro, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Hirai Makoto, Shibata Rei, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 69 ( 1-2 ) page: 3-10   2017

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    DOI: 10.1016/j.jjcc.2016.07.008

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  185. Impact of Renal Functional/Morphological Dynamics on the Calcification of Coronary and Abdominal Arteries in Patients with Chronic Kidney Disease

    Ichii Takeo, Morimoto Ryota, Okumura Takahiro, Ishii Hideki, Tatami Yosuke, Yamamoto Dai, Aoki Soichiro, Hiraiwa Hiroaki, Furusawa Kenji, Kondo Toru, Watanabe Naoki, Kano Naoaki, Fukaya Kenji, Sawamura Akinori, Suzuki Susumu, Yasuda Yoshinari, Murohara Toyoaki

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   Vol. 24 ( 11 ) page: 1092 - 1104   2017

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    DOI: 10.5551/jat.39271

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  186. Impact of red blood cell distribution width on non-cardiac mortality in patients with acute decompensated heart failure with preserved ejection fraction

    Imai Ryo, Uemura Yusuke, Okumura Takahiro, Takemoto Kenji, Uchikawa Tomohiro, Koyasu Masayoshi, Ishikawa Shinji, Iwamiya Satoshi, Ozaki Yuta, Shibata Rei, Watarai Masato, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 70 ( 5-6 ) page: 591-597   2017

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    DOI: 10.1016/j.jjcc.2017.03.010

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  187. Dipeptidyl Peptidase 4 Inhibition Alleviates Shortage of Circulating Glucagon-Like Peptide-1 in Heart Failure and Mitigates Myocardial Remodeling and Apoptosis via the Exchange Protein Directly Activated by Cyclic AMP 1/Ras-Related Protein 1 Axis. Reviewed

    Aoyama M, Kawase H, Bando YK, Monji A, Murohara T.

    Circulation Heart Fail     page: ,,   2016

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  188. Wnt11 Gene Therapy with Adeno-associated Virus 9 Improves Recovery from Myocardial Infarction by Modulating the Inflammatory Response. Reviewed

    Morishita Y, Kobayashi K, Klyachko E, Jujo K, Maeda K, Losordo DW, Murohara T.

    Sci. Rep   Vol. 6   page: 21705   2016

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    DOI: 10.1038/srep21705

  189. The Effect of Sitagliptin on Carotid Artery Atherosclerosis in Type 2 Diabetes: The PROLOGUE Randomized Controlled Trial. Reviewed

    685. Oyama J, Murohara T, Kitakaze M, Ishizu T, Sato Y, Kitagawa K, Kamiya H, Ajioka M, Ishihara M, Dai K, Nanasato M, Sata M, Maemura K, Tomiyama H, Higashi Y, Kaku K, Yamada H, Matsuhisa M, Yamashita K, Bando YK, Kashihara N, Ueda S, Inoue T, Tanaka A, Node K; PROLOGUE Study Investigators.

    PLoS Med.   Vol. 2016 ( 13 ) page: e1002051   2016

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    DOI: e1002051

  190. Akt-girdin signaling in cancer-associated fibroblasts contributes to tumor progression Reviewed

    Yamamura Y, Asai N, Enomoto A, Kato T, Mii S, Kondo Y, Ushida K, Niimi K, Tsunoda N, Nagino M, Ichihara S, Furukawa K, Maeda K, Murohara T, Takahashi M.

    Cancer Res   Vol. 75   page: 813-823   2015

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  191. Wnt11 gene therapy with Adeno-associated Virus 9 improves the survival of mice with myocarditis induced by coxsackievirus B3 through the suppression of the inflammatory reaction. Reviewed

    Aoyama Y, Kobayashi K, Morishita Y, Maeda K, Murohara T.

      Vol. 84   page: 45-51   2015

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  192. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Reviewed

    Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP.

    Nature Medicine   Vol. 21   page: 820-826.   2015

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  193. East Asian variant of aldehyde dehydrogenase 2 (ALDH2*2) is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing syndrome. Reviewed

    Mizuno Y, Harada E, Morita S, Kinoshita K, Hayashida M, Shono M, Morikawa Y, Murohara T, Nakayama M, Yoshimura M, Yasue H.

    Circulation   Vol. 131   page: 1665-1673   2015

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  194. Neuron-Derived Neurotrophic Factor Ameliorates Adverse Cardiac Remodeling After Experimental Myocardial Infarction. Reviewed

    Joki Y, Ohashi K, Yuasa D, Shibata R, Kataoka Y, Kambara T, Uemura Y, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Kanemura N, Ito M, Ogawa H, Daida H, Murohara T, Ouchi N.

    Circulation Heart Failure   Vol. 8   page: 342-351   2015

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  195. Dental pulp-derived stem cell conditioned medium reduces cardiac injury following ischemia-reperfusion. Reviewed

    Yamaguchi S, Shibata R, Yamamoto N, Nishikawa M, Hibi H, Tanigawa T, Ueda M, Murohara T, Yamamoto A.

    Sci. Rep.   Vol. 5   2015

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    DOI: 10.1038/srep16295

  196. C1q/TNF-related protein 9 protects against acute myocardial injury through an AdipoR1-AMPK dependent mechanism. Reviewed

    Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H, Aprahamian T, Walsh K, Murohara T, Ouchi N.

    Mol. Cell. Biol.   Vol. 35   page: 2173-2185   2015

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  197. New endoplasmic reticulum stress regulator, Gipie, regulates the survival of vascular smooth muscle cells and the neointima formation after vascular injury. Reviewed

    Noda T, Maeda K, Hayano S, Asai N, Enomoto A, Takahashi M, Murohara T.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 35   page: 1246-1253   2015

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  198. An anti-angiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease. Reviewed

    Kikuchi R, Nakamura K, MacLauchian S, Shimizu I, Fuster JJ, Katanasaka Y, Qiu Y, Yamaguchi TP, Matsushita T, Murohara T, Bates DO, Hamburg NM, Walsh K.

    Nature Medicine   Vol. 20   page: 1464-1471   2014

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  199. Vildagliptin stimulates endothelial cell network formation and ischemia-induced revascularization via an endothelial nitric oxide synthase-dependent mechanism. Reviewed

    Ishii M, Shibata R, Kondo K, Kambara T, Shimizu Y, Tanigawa T, Bando YK, Nishimura M, Ouchi N, Murohara T.

    J. Biol. Chem.   Vol. 289   page: 27235-27245   2014

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  200. Adiponectin-mediated modulation of lymphatic vessel formation and lymphedema Reviewed

    Shimizu Y, Shibata R, Ishii M, Ohashi K, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Kihara S, Murohara T, Ouchi N.

    J. Am. Heart Assoc.   Vol. 2   page: e000438   2013

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  201. Evidence for the importance of adiponectin in the cardioprotective effects of pioglitazone. Reviewed

    Li P, Shibata R, Unno K, Shimano M, Furukawa M, Ohashi T, Cheng X, Nagata K, Ouchi N, Murohara T

    Hypertension   Vol. 55 ( 1 ) page: 69-75   2010.5

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  202. *Implantation of adipose-derived regenerative cells enhances ischemia-induced angiogenesis. Reviewed

    Kondo K, Shintani S, Shibata R, Murakami H, Murakami R, Imaizumi T, Kitagawa S, Murohara T.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 29   page: 61-66   2009

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  203. Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP. Reviewed

    Mori K, Amano M, Takefuji M, Kato K, Morita Y, Nishioka T, Matsuura Y, Murohara T, Kaibuchi K.

    J. Biol. Chem.   Vol. 284   page: 5067-5076   2009

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  204. *Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of eNOS. Reviewed

    Kondo M, Shibata R, Miura R, Shimano M, Kondo K, Li P, Ohashi T, Kihara S, Maeda N, Walsh K, Ouchi N, Murohara T.

    J. Biol. Chem.   Vol. 284   page: 1718-1724   2009

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  205. Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis. Reviewed

    Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Amano T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

    Nephrol. Dial. Transplant.   Vol. 24   page: 1562-1567   2009

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  206. Restored cardiac conditions and left ventricular function after parathyroidectomy in a hemodialysis patient. Reviewed

    Nanasato M, Goto N, Isobe S, Unno K, Hirayama H, Sato T, Matsuoka S, Nagasaka T, Tominaga Y, Uchida K, Murohara T.

    Circ. J.   Vol. 73   page: 1956-1960   2009

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  207. Autologous adipose-derived regenerative cells for therapeutic angiogenesis. Invited Reviewed

    Murohara T, Shintani S, Kondo T.

    Curr. Pharm. Des.   Vol. 15   page: 2784-2790   2009

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  208. Intracoronary electrocardiogram recording with a bare-wire system: perioperative ST-segment elevation in the intracoronary electrocardiogram Is associated with myocardial injury after elective coronary stent implantation. Reviewed

    Uetani T, Amano T, Kumagai S, Ando H, Yokoi K, Yoshida T, Kato B, Kato M, Marui N, Nanki M, Matsubara T, Ishii H, Izawa H, Murohara T.

    JACC. Cardiovasc. Interv.   Vol. 2   page: 127-135   2009

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  209. Differentiation capacity of endothelial progenitor cells correlates with endothelial function in healthy young men. Reviewed

    Miura M, Numaguchi Y, Ishii M, Kubota R, Takeuchi T, Imamura A, Murakami R, Kondo T, Okumura K, Murohara T.

    Circ J.   Vol. 73   page: 1324-1329   2009

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  210. Gamma-secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice. Reviewed

    Aoyama T, Takeshita K, Kikuchi R, Yamamoto K, Cheng XW, Liao JK, Murohara T.

    Biochem. Biophys. Res. Commun.   Vol. 383   page: 216-221   2009

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  211. Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia. Reviewed

    Ishii M, Numaguchi Y, Okumura K, Kubota R, Ma X, Murakami R, Naruse K, Murohara T.

    Atherosclerosis   Vol. 206   page: 109-118   2009

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  212. Autologous adipose tissue as a new source of progenitor cells for therapeutic angiogenesis. Invited Reviewed

    Murohara T

    J. Cardiol.   Vol. 53   page: 155-163   2009

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  213. Renal protective effects and the prevention of contrast-induced nephropathy by atrial natriuretic peptide. Reviewed

    Morikawa S, Sone T, Tsuboi H, Mukawa H, Morishima I, Uesugi M, Morita Y, Numaguchi Y, Okumura K, Murohara T.

    J. Am. Coll. Cardiol.   Vol. 53   page: 1040-1046   2009

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  214. Molecular imaging of matrix metalloproteinase expression in atherosclerotic plaques of mice deficient in apolipoprotein e or low-density-lipoprotein receptor. Reviewed

    Ohshima S, Petrov A, Fujimoto S, Zhou J, Azure M, Edwards DS, Murohara T, Narula N, Tsimikas S, Narula J.

    J. Nucl. Med.   Vol. 50   page: 612-617   2009

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  215. Adiponectin and cardiovascular disease. Reviewed

    Shibata R, Ouchi N, Murohara T.

    Circ J   Vol. 73   page: 608-614   2009

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  216. Uric acid and left ventricular hypertrophy in Japanese men. Reviewed

    Mitsuhashi H, Yatsuya H, Matsushita K, Zhang H, Otsuka R, Muramatsu T, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H, Tamakoshi K.

    Circ. J.   Vol. 73   page: 632-638   2009

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  217. Role of bradykinin, nitric oxide and angiotensin II type 2 receptor in imidapril-induced angiogenesis. Reviewed

    Li P, Kondo T, Numaguchi Y, Kobayashi K, Aoki M, Inoue N, Murohara T.

    Hypertension   Vol. 51   page: 252-258   2008

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  218. *Pharmacological intervention for prevention of left ventricular remodeling and improving prognosis in myocardial infarction. Reviewed

    Ishii H, Amano T, Matsubara T, Murohara T.

    Circulation   Vol. 118   page: 2710-2718   2008

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  219. Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia. Reviewed

    Matoba S, Tatsumi T, Murohara T, Imaizumi T, Katsuda Y, Ito M, Saito Y, Uemura S, Suzuki H, Fukumoto S, Yamamoto Y, Onodera R, Teramukai S, Fukushima M, Matsubara H; TACT Follow-up Study Investigators.

    Am. Heart J.   Vol. 156   page: 1010-1018   2008

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  220. *Nifedipine improves endothelial function: role of endothelial progenitor cell. Reviewed

    Sugiura T, Kondo T, Kureishi-Bando Y, Numaguchi Y, Yoshida O, Dohi Y, Kimura G, Ueda R, Rabelink TJ, Murohara T

    Hypertension.   Vol. 52   page: 491-498   2008

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  221. Circulating adiponectin levels in patients with atrial fibrillation. Reviewed

    Shimano M, Shibata R, Tsuji Y, Kamiya H, Uchikawa T, Harata S, Muto M, Ouchi N, Inden Y, Murohara T.

    Circ. J.   Vol. 72   page: 1120-1124   2008

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  222. The correlation between lipid volume in the target lesion, measured by integrated backscatter intravascular ultrasound, and post-procedural myocardial infarction in patients with elective stent implantation. Reviewed

    Uetani T, Amano T, Ando H, Yokoi K, Arai K, Kato M, Marui N, Nanki M, Matsubara T, Ishii H, Izawa H, Murohara T.

    Eur. Heart J.   Vol. 29   page: 1714-1720   2008

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  223. Adiponectin promotes endothelial progenitor cell number and function. Reviewed

    Shibata R, Skurk C, Ouchi N, Galasso G, Kondo K, Ohashi T, Kihara S, Murohara T, Walsh K.

    FEBS Lett.   Vol. 582   page: 1607-1612   2008

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  224. Cilostazol improves long-term patency after percutaneous transluminal angioplasty in hemodialysis patients with peripheral artery disease. Reviewed

    Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Yamada S, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

    Clin. J. Am. Soc. Nephrol.   Vol. 3   page: 1034-1040   2008

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  225. *Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. Reviewed

    Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, Jiang P, Watanabe T, Usukura J, Kondo T, Costantini F, Murohara T, Takahashi M.

    Nat. Cell Biol.   Vol. 10   page: 329-337   2008

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  226. Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model. Reviewed

    Urano T, Ito Y, Akao M, Sawa T, Miyata K, Tabata M, Morisada T, Hato T, Yano M, Kadomatsu T, Yasunaga K, Shibata R, Murohara T, Akaike T, Tanihara H, Suda T, Oike Y.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 28   page: 827-834   2008

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  227. Abnormal glucose regulation is associated with lipid rich coronary plaque: relationship to insulin resistance. Reviewed

    Amano T, Matsubara T, Uetani T, Nanki M, Marui N, Kato M, Yoshida T, Arai K, Yokoi K, Ando H, Kumagai S, Ishii H, Izawa H, Hotta N, Murohara T.

    JACC. Cardiovasc. Imaging.   Vol. 1   page: 39-45   2008

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  228. Construction of multilayered cardiomyocyte sheets using magnetite nanoparticles and magnetic force. Reviewed

    Shimizu K, Ito A, Lee JK, Yoshida T, Miwa K, Ishiguro H, Numaguchi Y, Murohara T, Kodama I, Honda H.

    Biotechnol. Bioeng.   Vol. 96   page: 803-809   2007

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  229. Angiotensin II receptor blocker inhibits neointimal hyperplasia through regulation of smooth muscle-like progenitor cells. Reviewed

    Yamada T, Kondo T, Numaguchi Y, Tsuzuki M, Matsubara T, Manabe I, Sata M, Nagai R, Murohara T.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 27   page: 2363-2369   2007

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  230. Effect of autologous bone marrow cell transplantation on ischemic ulcer in patients with Burger's disease. Reviewed

    Saito Y, Sasaki K, Katsuda Y, Murohara T, Takeshita Y, Okazaki T, Arima K, Katsuki Y, Shintani S, Shimada T, Akashi H, Ikeda H, Imaizumi T.

    Circ. J.   Vol. 71   page: 1187-1192.   2007

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  231. High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Yang PO, Otsuka R, Wada K, Mitsuhashi H, Hotta Y, Kondo T, Murohara T, Toyoshima H.

    Circ J.   Vol. 71   page: 820-825   2007

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  232. Adiponectin level and left ventricular hypertrophy in Japanese men. Reviewed

    Mitsuhashi H, Yatsuya H, Tamakoshi K, Matsushita K, Otsuka R, Wada K, Sugiura K, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H.

    Hypertension.   Vol. 49   page: 1448-1454   2007

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  233. A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis. Reviewed

    Ichihara S, Yamada Y, Ichihara G, Nakajima T, Li P, Kondo T, Gonzales FJ, Murohara T.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 27   page: 1297-1304   2007

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  234. Prevalence and severity of left atrial edema detected by electron beam tomography early after pulmonary vein ablation. Reviewed

    Okada T, Yamada T, Murakami Y, Yoshida N, Ninomiya Y, Shimizu T, Toyama J, Yoshida Y, Ito T, Tsuboi N, Kondo T, Inden Y, Hirai M, Murohara T.

    J. Am. Coll. Cardiol.   Vol. 49   page: 1436-1442   2007

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  235. Efficacy of oral nicorandil in patients with end-stage renal disease: a retrospective chart review after coronary angioplasty in Japanese patients receiving hemodialysis. Reviewed

    Ishii H, Toriyama T, Aoyama T, Takahashi H, Yamada S, Kasuga H, Ichimiya S, Kanashiro M, Mitsuhashi H, Maruyama S, Matsuo S, Naruse K, Matsubara T, Murohara T.

    Clin. Ther.   Vol. 29   page: 110-122   2007

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  236. Impact of metabolic syndrome on tissue characteristics of angiographically mild to moderate coronary lesions: Integrated backscatter intravascular ultrasound study. Reviewed

    Amano T, Matsubara T, Uetani T, Nanki M, Marui N, Kato M, Arai K, Yokoi K, Ando H, Ishii H, Izawa H, Murohara T.

    J. Am. Coll. Cardiol.   Vol. 49   page: 1149-1156   2007

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  237. Mechanisms underlying the impairment of ischemia-induced neovascularization in MMP-2-deficient mice. Reviewed

    Cheng XW, Kuzuya M, Nakamura K, Maeda K, Tsuzuki M, Kim W, Sasaki T, Liu Z, Inoue N, Kondo T, Jin H, Numakuchi Y, Okumura K, Yokota M, Iguchi A, Murohara T.

    Circ. Res.   Vol. 100   page: 904-913   2007

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  238. Rro-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation. Reviewed

    Takefuji M, Mori K, Morita Y, Arimura N, Nishimura T, nakayama M, Hoshino M, Iwamatsu A, Murohara T, kaibuchi K, Amano M.

    Biochem. Biophys. Res. Commun.   Vol. 355   page: 788-794   2007

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  239. Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia. Reviewed

    Kajiguchi M, Kondo T, Izawa H, Kobayashi K, Yamamoto K, Shintani S, Numaguchi Y, Naoe T, Takamatsu J, Komori K, Murohara T.

    Circ. J.   Vol. 71   page: 196-201   2007

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  240. Depletion of endothelial progenitor cells in the peripheral blood of patients with ulcerative colitis. Reviewed

    Masuda J, Mitsuyama K, Yamasaki H, Takedatsu H, Okamura T, Andoh A, Murohara T, Asahara T, Sata M.

    Int. J. Mol. Med.   Vol. 19   page: 221-228   2007

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  241. Therapeutic angiogenesis using novel vascular endothelial growth factor-E/human placental growth factor chimera genes. Reviewed

    Inoue N, Kondo T, Kobayashi K, Aoki M, Numaguchi Y, Shibuya M, Murohara T.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 27   page: 99-105   2007

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  242. A strategy of retrograde injection of bone marrow mononuclear cells into the myocardium for the treatment of ischemic heart disease. Reviewed

    Yokoyama S, Fukuda N, Li Y, Hagikura K, Takayama T, Kunimoto S, Honye J, Saito S, Wada M, Satomi A, Kato M, Mugishima H, Kusumi Y, Mitsumata M, Murohara T.

    J. Mol. Cell. Cardiol.   Vol. 40   page: 24-34   2006

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  243. Effects of receipt of chronic statin therapy before the onset of acute myocardial infarction: A retrospective study in patients with primary percutaneous coronary intervention. Reviewed

    Ishii H, Ichimiya S, Kanashiro M, Aoyama T, Ogawa Y, Murakami R, Amano T, Naruse K, Matsubara T, Murohara T.

    Clin. Ther.   Vol. 28   page: 1812-1819   2006

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  244. Clinical Protocol: Angiogenesis by Intramyocardial Injection of Autologous Bone Marrow Mononuclear Cells in Patients with Severe Coronary Artery Disease. TACT-NAGOYA-HEART. Reviewed

    Izawa H, Kondo T, Usui A, Yamamoto K, Shintani S, Inden Y, Isobe S, Unno K, Kajiguchi M, Noda A, Yokota M, Takamatsu J, Ueda Y, Komori K, Murohara T.

    Circ. J.   Vol. 70   page: 1180-1183   2006

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  245. l-Caldesmon regulates proliferation and migration of vascular smooth muscle cells and inhibits neointimal formation after angioplasty. Reviewed

    Yokouchi K, Numaguchi Y, Okumura K, Ishii M, Kubota R, Imai H, Murakami R, Kondo T, Murohara T.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 26   page: 2231-2237   2006

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  246. Evaluation of compliance and stiffness of decellularized tissues as scaffolds for tissue-engineered small caliber vascular grafts using intravascular ultrasound. Reviewed

    Murase Y, Narita Y, Kagami H, Miyamoto K, Ueda Y, Ueda M, Murohara T.

    ASAIO J.   Vol. 52   page: 450-455   2006

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  247. Effect of green tea consumption on endothelial function and circulating endothelial progenitor cells in chronic smokers. Reviewed

    Kim W, Jeong MH, Cho SH, Yun JH, Chae HJ, Ahn YK, Lee MC, Cheng X, Kondo T, Murohara T, Kang JC.

    Circ. J.   Vol. 70   page: 1052-1057   2006

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  248. The prostacyclin analog, beraprost sodium, augments the efficacy of therapeutic angiogenesis induced by autologous bone marrow cells. Reviewed

    Otsuka H, Akashi H, Murohara T, Okazaki T, Shintani S, Tayama K, Sasaki K, Imaizumi T, Aoyagi S.

    Ann. Vasc. Surg.   Vol. 20   page: 646-652   2006

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  249. Comparison of percutaneous coronary intervention with medication in the treatment of coronary artery disease in hemodialysis patients. Reviewed

    Yasuda K, Kasuga H, Aoyama T, Takahashi H, Toriyama T, Kawade Y, Iwashima S, Yamada S, Kawahara H, Maruyama S, Yuzawa Y, Ishii H, Murohara T, Matsuo S.

    J. Am. Soc. Nephrol.   Vol. 17   page: 2322-2332   2006

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  250. The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction. Reviewed

    Numaguchi Y, Sone T, Okumura K, Morita Y, Kubota R, Yokouchi K, Imai H, Harada M, Kondo T, Murohara T.

    Circulation.   Vol. 114   page: I114-I119   2006

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  251. Plasma atrial natriuretic peptide and brain natriuretic peptide levels after radiofrequency catheter ablation of atrial fibrillation. Reviewed

    Yamada T, Murakami Y, Okada T, Okamoto M, Shimizu T, Toyama J, Yoshida Y, Tsuboi N, Ito T, Muto M, Kondo T, Inden Y, Hirai M, Murohara T.

    Am. J. Cardiol.   Vol. 97   page: 1741-1744   2006

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  252. Usefulness of esophageal leads for determining the strategy of pulmonary vein ablation to avoid complications associated with the esophagus. Reviewed

    Yamada T, Murakami Y, Okada T, Okamoto M, Shimizu T, Toyama J, Yoshida Y, Tsuboi N, Ito T, Muto M, Kondo T, Inden Y, Hirai M, Murohara T.

    Am. J. Cardiol.   Vol. 97   page: 1494-1497   2006

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  253. Combination therapy using angiopoietin-1 plasmid gene and autologous bone marrow cell implantation promotes functional angiogenesis. Reviewed

    Kobayashi K, Kondo T, Inoue N, Aoki M, Mizuno M, Komori K, Yoshida J, Murohara T.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 26   page: 1465-1472   2006

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  254. Ischemia-induced angiogenesis: role of inflammatory response mediated by P-selectin. Reviewed

    Egami K, Murohara T, Aoki M, Matsuishi T.

    J. Leukoc. Biol.   Vol. 79   page: 971-976   2006

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  255. Incidence, location, and cause of recovery of electrical connections between the pulmonary veins and the left atrium after pulmonary vein isolation. Reviewed

    Yamada T, Murakami Y, Okada T, Okamoto M, Shimizu T, Toyama J, Yoshida Y, Tsuboi N, Ito T, Muto M, Kondo T, Inden Y, Hirai M, Murohara T.

    Europace.   Vol. 83   page: 182-188   2006

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  256. Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese. Reviewed

    Imamura A, Okumura K, Ogawa Y, Murakami R, Torigoe M, Numaguchi Y, Murohara T.

    Clin. Chim. Acta.   Vol. 371   page: 66-70   2006

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  257. Electrophysiological pulmonary vein antrum isolation with a multielectrode basket catheter is feasible and effective for curing paroxysmal atrial fibrillation: Efficacy of minimally extensive pulmonary vein isolation. Reviewed

    Yamada T, Murakami Y, Okada T, Okamoto M, Shimizu T, Toyama J, Yoshida Y, Tsuboi N, Ito T, Muto M, Kondo T, Inden Y, Hirai M, Murohara T.

    Heart Rhythm.   Vol. 3(Suppl.)   page: 377-384   2006

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  258. Peroxisome proliferators-activated receptor a activation, in addition to carnitine supplementation, rescues the detrimental lipotoxic cardiomyopathy due to disorder of fatty acid oxidation in a murine model of systemic carnitine deficiency. Reviewed

    Asai T, Okumura K, Takahashi R, Matsui H, Numaguchi Y, Murakami H, Murakami R, Murohara T.

    Cardiovasc. Res.   Vol. 70   page: 566-577   2006

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  259. Impact of plasma aldosterone levels for prediction of in-stent restenosis. Reviewed

    Amano T, Matsubara T, Izawa H, Torigoe M, Yoshida T, Hamaguchi Y, Ishii H, Miura M, Hayashi Y, Ogawa Y, Murohara T.

    Am. J. Cardiol.   Vol. 97   page: 785-788   2006

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  260. Synergistic effect of combined intramyocardial CD34 cells and VEGF-2 gene therapy post-myocardial infarction. Reviewed

    Shintani S, Kusano K, Ii M, Iwakura A, Heyd L, Curry C, Wecker A, Gavin M, Ma H, Kearney M, Silver M, Thorne T, Murohara T, Losordo DW.

    Nat. Clin. Pract. Cardiovasc. Med.   Vol. 3(Suppl.)   page: S123-S128   2006

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  261. Endothelial progenitor cell transplantation improves the outcome following liver injury in mice. Reviewed

    Taniguchi E, Kin M, Torimura T, Nakamura T, Kumemura M, Hanada S, Hisamoto T, Yoshida T, Kawaguchi T, Baba S, Maeyama M, Koga H, Harada M, Kumashiro R, Ueno T, Ikeda H, Imaizumi T, Murohara T, Sata M.

    Gastroenterology.   Vol. 130   page: 521-531   2006

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  262. Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Takefuji S, Sugiura K, Kondo T, Murohara T, Toyoshima H.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 26   page: 871-876   2006

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  263. Effects of intravenous nicorandil before reperfusion for acute myocardial infarction in patients with stress hyperglycemia. Reviewed

    Ishii H, Ichimiya S, Kanashiro M, Amano T, Matsubara T, Murohara T.

    Diabetes Care.   Vol. 29   page: 202-206   2006

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  264. Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Zhang H, Sugiura K, Kondo T, Murohara T, Toyoshima H.

    Atherosclerosis.   Vol. 188   page: 184-189   2006

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  265. Platelet P-selectin plays an important role in arterial thrombogenesis by forming large stable platelet-leukocyte aggregates. Reviewed

    Yokoyama S, Ikeda H, Haramaki N, Yasukawa H, Murohara T, Imaizumi T.

    J. Am. Coll. Cardiol.   Vol. 45   page: 1280-1286   2005

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  266. Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy. Reviewed

    Naruse K, Hamada Y, Nakashima E, Kato K, Mizubayashi R, Kamiya H, Yuzawa Y, Matsuo S, Murohara T, Matsubara T, Oiso Y, Nakamura J.

    Diabetes.   Vol. 54   page: 1823-1828   2005

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  267. Therapeutic angiogenesis with intramuscular injection of low dose recombinant granulocyte-colony stimulating factor. Reviewed

    Lee M, Aoki M, Kondo T, Okumura K, Komori K, Murohara T.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 25   page: 2535-2541   2005

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  268. The impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment elevation myocardial infarction. Reviewed

    Ishii H, Ichimiya S, Kanashiro M, Amano T, Imai K, Murohara T, Matsubara T.

    Circulation.   Vol. 112   page: 1284-1288   2005

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  269. CD34+ cells home, proliferate and participate in capillary formation and in combination with CD34- cells enhance tube formation in a 3D matrix. Reviewed

    Rookmaaker MB, Verhaar MC, Loomans CJM, Peters E, Murohara T, Staal FJT, van Zonneveld AJ, Koolwijk P, Rabelink TJ, van Hinsbergh VWM.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 25   page: 1843-1850   2005

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  270. Important role of apoptosis signal-regulating kinase 1 in ischemia-induced angiogenesis. Reviewed

    Izumi Y, Kim-Mitsuyama S, Yoshiyama M, Omura T, Shiota M, Matsuzawa A, Yukimura T, Murohara T, Takeya M, Ichijo H, Yoshikawa J, Iwao H.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 25   page: 1877-1883   2005

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  271. Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia. Reviewed

    Higashi Y, Kimura M, Hara K, Noma K, Jituiki D, Nakagawa K, Oshima T, Chayama K, Goto C, Matsubara H, Murohara T, Yoshizumi M.

    Circulation.   Vol. 109   page: 1215-1218   2004

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  272. Augmentation of therapeutic angiogenesis using genetically-modified human endothelial progenitor cells with altered glycogen synthase kinase-3b activity. Reviewed

    Choi JH, Hur J, Yoon CH, Kim JH, Lee CS, Youn SW, Oh IY, Skurk C, Murohara T, Park YB, Walsh K, Kim HS.

    J. Biol. Chem.   Vol. 279   page: 49430-49438   2004

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  273. Angiogenesis and vasculogenesis are impaired in precocious aging Klotho mouse. Reviewed

    Shimada T, Takeshita Y, Murohara T, Sasaki K, Egami K, Shintani S, Katsuda Y, Ikeda H, Nabeshima Y, Imaizumi T.

    Circulation.   Vol. 110   page: 1148-1155   2004

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  274. Inhibition of platelet adherence to mononuclear cells by α-tocopherol: Role of P-selectin. Reviewed

    Murohara T, Ikeda H, Otsuka Y, Aoki M, Haramaki N, Katoh A, Takajo Y, Imaizumi T.

    Circulation.   Vol. 110   page: 141-148   2004

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  275. Roles of endogenous monocyte chemoattractant protein-1 in ischemia-induced neovascularization. Reviewed

    Niiyama H, Kai H, Yamamoto T, Shimada T, Sasaki K, Murohara T, Egashira K, Imaizumi T.

    J. Am. Coll. Cardiol.   Vol. 44   page: 661-666   2004

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  276. Smoking cessation rapidly increases endothelial progenitor cells in peripheral blood in chronic smokers. Reviewed

    Kondo T, Hayashi M, Kinoshita K, Kobayashi K, Iino S, Inden Y, Murohara T.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 24   page: 1442-1447   2004

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  277. Derivation of functional endothelial progenitor cells from human umbilical cord blood mononuclear cells isolated by a novel cell filtration device. Reviewed

    Aoki M, Yasutake M, Murohara T.

    Stem Cells.   Vol. 22   page: 994-1002   2004

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  278. Molecular evaluation of endothelial progenitor cells in patients with ischemic limbs: therapeutic effect by stem cell transplantation. Reviewed

    Yamamoto K, Kondo T, Suzuki S, Izawa H, Kobayashi M, Emi N, Komori K, Naoe T, Takamatsu J, Murohara T.

    Arterioscler. Throm. Vasc. Biol.   Vol. 24   page: e192-e196   2004

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  279. Hypoxic preconditioning augments efficacy of human endothelial progenitor cells for therapeutic neovascularization. Reviewed

    Akita T, Murohara T, Ikeda H, Sasaki K, Shimada T, Egami K, Imaizumi T.

    Lab. Invest.   Vol. 83   page: 65-73   2003

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  280. Rescue of hypercholesterolemia-related impairment of angiogenesis by oral folate supplementation. Reviewed

    Sasaki K, Duan J, Murohara T, Ikeda H, Shintani S, Shimada T, Akita T, Egami K, Imaizumi T.

    J. Am. Coll. Cardiol.   Vol. 42   page: 364-372   2003

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  281. Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth. Reviewed

    Egami K, Murohara T, Shimada T, Sasaki K, Shintani S, Sugaya T, Ishii M, Akagi T, Ikeda H, Matsuishi T, Imaizumi T.

    J. Clin. Invest.   Vol. 112   page: 67-75   2003

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  282. Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis. Reviewed

    Sasaki K, Murohara T, Ikeda H, Sugaya T, Shintani S, Shimada T, Imaizumi T.

    J. Clin. Invest.   Vol. 109   page: 603-611   2002

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  283. for the Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Reviewed

    Tateishi-Yuyama E,* Matsubara H,* Murohara T,* Ikeda U, Shintani S, Masaki H, Amano K, Kishimoto Y, Yoshimoto K, Akashi H, Shimada K, Iwasaka T, Imaizumi T. * equal contribution.

    Lancet.   Vol. 360   page: 427-435   2002

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  284. Augmentation of postnatal neovascularization with autologous bone marrow transplantation. Reviewed

    Shintani S, Murohara T, Ikeda H, Ueno T, Sasaki K, Duan J, Imaizumi T.

    Circulation.   Vol. 103   page: 897-903   2001

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  285. Intraplatelet tetrahydrobiopterin plays an important role in regulating canine coronary arterial thrombosis by modulating intraplatelet nitric oxide and superoxide generation. Reviewed

    Kanaya S, Ikeda H, Haramaki N, Murohara T, Imaizumi T.

    Circulation.   Vol. 104   page: 2478-2484   2001

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  286. Augmented oxidative stress of platelets in chronic smokers. Mechanisms of impaired platelet-derived nitric oxide bioactivity and augmented platelet aggregability. Reviewed

    Takajo Y, Ikeda H, Haramaki N, Murohara T, Imaizumi T.

    J. Am. Coll. Cardiol.   Vol. 38   page: 1320-1327   2001

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  287. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Reviewed

    Shintani S, Murohara T, Ikeda H, Ueno T, Honma T, Katoh A, Sasaki K, Shimada T, Oike Y, Imaizumi T.

    Circulation.   Vol. 103   page: 2776-2779   2001

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  288. Platelet-derived nitric oxide and coronary risk factors. Reviewed

    Ikeda H, Takajo Y, Murohara T, Ichiki K, Adachi H, Haramaki N, Katoh A, Imaizumi T.

    Hypertension.   Vol. 35   page: 904-907   2000

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  289. Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism. Reviewed

    Duan J, Murohara T, Ikeda H, Katoh A, Shintani S, Sasaki K, Kawata H, Yamamoto N, Imaizumi T.

    Circulation.   Vol. 102   page: III370-III376   2000

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  290. Increased circulating soluble intercellular adhesion molecule-1 in acute myocardial infarction: a possible predictor of reperfusion ventricular arrhythmias. Reviewed

    Murohara T, Kamijikkoku S, Honda T.

    Crit. Care Med.   Vol. 28   page: 1861-1864   2000

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  291. Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. Reviewed

    Murohara T, Ikeda H, Duan J, Shintani S, Sasaki K, Eguchi H, Onitsuka I, Matsui K, Imaizumi T.

    J. Clin. Invest.   Vol. 28   page: 1861-1864   2000

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  292. Age-dependent impairment of angiogenesis. Reviewed

    Rivard A, Fabre JE, Silver M, Chen D, Murohara T, Kearney M, Magner M, Asahara T, Isner JM.

    Circulation.   Vol. 99   page: 111-120   1999

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  293. Adhesive interaction between P-selectin and sialyl Lewis(x) plays an important role in recurrent coronary arterial thrombosis in dogs. Reviewed

    Ikeda H, Ueyama T, Murohara T, Yasukawa H, Haramaki N, Eguchi H, Katoh A, Takajo Y, Onitsuka I, Ueno T, Tojo SJ, Imaizumi T.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 19   page: 1083-1090   1999

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  294. Endothelial injuries of coronary arteries distal to thrombotic sites: role of adhesive interaction between endothelial P-selectin and leukocyte sialyl LewisX. Reviewed

    Eguchi H, Ikeda H, Murohara T, Yasukawa H, Haramaki N, Sakisaka S, Imaizumi T.

    Circ. Res.   Vol. 84   page: 525-535   1999

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  295. Role of endothelial nitric oxide synthase in endothelial cell migration. Reviewed

    Murohara T, Witzenbichler B, Spyridopoulos I, Asahara T, Ding B, Sullivan A, Losordo DW, Isner JM.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 19   page: 1156-1161   1999

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  296. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Reviewed

    Murohara T, Horowitz JR, Silver M, Tsurumi Y, Chen D, Sullivan A, Isner JM.

    Circulation.   Vol. 97   page: 99-107   1998

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  297. Platelet-derived 12-hydroxyeicosatetraenoic acid plays an important role in mediating canine coronary thrombosis by regulating platelet glycoprotein IIb/IIIa activation. Reviewed

    Katoh A, Ikeda H, Murohara T, Haramaki N, Ito H, Imaizumi T.

    Circulation.   Vol. 98   page: 2891-2898   1998

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  298. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. Reviewed

    Murohara T, Asahara T, Silver M, Bauters C, Masuda H, Kalka C, Kearney M, Chen D, Symes JF, Fishman MC, Huang PL, Isner JM.

    J. Clin. Invest.   Vol. 101   page: 2567-2578   1998

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  299. Isolation of putative progenitor endothelial cells for angiogenesis. Reviewed

    Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM.

    Science.   Vol. 275   page: 964-967   1997

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  300. Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Reviewed

    Tsurumi Y, Murohara T, Krasinski K, Chen D, Witzenbichler B, Kearney M, Couffinhal T, Isner JM.

    Nat. Med.   Vol. 37   page: 879-886   1997

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  301. Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium. Reviewed

    van der Zee R, Murohara T, Luo Z, Zollmann F, Passeri J, Lekutat C, Isner JM.

    Circulation.   Vol. 95   page: 1030-1037   1997

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  302. Interactions of nitrovasodilators, atrial natriuretic peptide and endothelium-derived nitric oxide. Reviewed

    Murohara T, Kugiyama K, Yasue H.

    J. Vasc. Res.   Vol. 33   page: 78-85   1996

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  303. Autocrine effects of endothelin-1 on leukocyte-endothelial interaction: stimulation of endothelin B receptor subtype reduces endothelial adhesiveness via a nitric oxide-dependent mechanism. Reviewed

    Murohara T, Lefer AM.

    Blood.   Vol. 88   page: 3894-3900   1996

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  304. Effects of sphingomyelinase and sphingosine on arterial vasomotor regulation. Reviewed

    Murohara T, Kugiyama K, Ohgushi M, Sugiyama S, Ohta Y, Yasue H.

    J. Lipid Res.   Vol. 37   page: 1601-1608   1996

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  305. Effects of angiotensin-converting enzyme inhibitor alacepril in patients with stable effort angina during chronic isosorbide dinitrate treatment. Reviewed

    Murohara T, Tayama S, Tabuchi T, Sumida H, Honda T, Hayasaki K, Yasue H.

    Am. J. Cardiol.   Vol. 77   page: 1159-1163   1996

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  306. Blockade of platelet endothelial cell adhesion molecule-1 protects against myocardial ischemia and reperfusion injury in cats. Reviewed

    Murohara T, Delyani JA, Albelda SM, Lefer AM.

    J. Immunol.   Vol. 156   page: 3550-3557   1996

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  307. Lysophosphatidylcholine promotes P-selectin expression in platelets and endothelial cells. Possible involvement of protein kinase C activation and its inhibition by nitric oxide donors. Reviewed

    Murohara T, Scalia R, Lefer AM.

    Circ. Res.   Vol. 78   page: 780-789   1996

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  308. Cardioprotective actions of oligotide, a single stranded polydeoxyribonucleotide complex, in myocardial ischaemia and reperfusion injury. Reviewed

    Murohara T, Buerke M, Lefer AM.

    Br. J. Pharmacol.   Vol. 117   page: 1000-1008   1996

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  309. Myocardial and endothelial protection by TMS in ischemia-reperfusion injury. Reviewed

    Murohara T, Buerke M, Margiotta J, Ruan F, Igarashi Y, Hakomori S, Lefer AM.

    Am. J. Physiol.   Vol. 269   page: H504-H514   1995

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  310. Cardioprotective effects of a C1 esterase inhibitor in myocardial ischemia and reperfusion. Reviewed

    Buerke M, Murohara T, Lefer AM.

    Circulation.   Vol. 91   page: 393-402   1995

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  311. Cardioprotection by liposome-conjugated sialyl Lewisx-oligosaccharide in myocardial ischaemia and reperfusion injury. Reviewed

    Murohara T, Margiotta J, Phillips LM, Paulson JC, DeFrees S, Zalipsky S, Guo LS, Lefer AM.

    Cardiovasc. Res.   Vol. 30   page: 965-974   1995

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  312. Inhibition of nitric oxide biosynthesis promotes P-selectin expression in platelets. Role of protein kinase C. Reviewed

    Murohara T, Parkinson SJ, Waldman SA, Lefer AM.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 15   page: 2068-2075   1995

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  313. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Reviewed

    Buerke M, Murohara T, Skurk C, Nuss C, Tomaselli K, Lefer AM.

    Proc. Natl. Acad. Sci. U S A.   Vol. 92   page: 8031-8035   1995

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  314. Cigarette smoke extract contracts isolated porcine coronary arteries by superoxide anion-mediated degradation of EDRF. Reviewed

    Murohara T, Kugiyama K, Ohgushi M, Sugiyama S, Yasue H.

    Am. J. Physiol.   Vol. 266   page: H874-H880   1994

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  315. Polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction. Role of selectins. Reviewed

    Murohara T, Buerke M, Lefer AM.

    Arterioscler. Thromb. Vasc. Biol.   Vol. 14   page: 1509-1519   1994

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  316. LPC in oxidized LDL elicits vasocontraction and inhibits endothelium- dependent relaxation. Reviewed

    Murohara T, Kugiyama K, Ohgushi M, Sugiyama S, Ohta Y, Yasue H.

    Am. J. Physiol.   Vol. 267   page: H2441-H2449   1994

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  317. Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries. Reviewed

    Murohara T, Yasue H, Ohgushi M, Sakaino N, Jougasaki M.

    Cardiovasc. Res.   Vol. 25   page: 1002-1009   1991

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▼display all

Research Project for Joint Research, Competitive Funding, etc. 3

  1. 細胞移植と遺伝子治療を組み合わせた効率的な血管再生療法の開発

    2006 - 2007

    財団法人 武田科学振興財団 

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    Grant type:Competitive

  2. 前駆細胞移植による血管再生療法の分子基盤探索と新規臨床応用に向けた展開研究

    2006

  3. 自家骨髄細胞移植による重症末梢動脈硬化症・虚血性心疾患に対する血管新生療法の完成

    2003 - 2005

    (財)テルモ科学技術振興財団 特定研究助成 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 28

  1. Role of myokines in preventing the development of age-related diseases

    Grant number:20H00571  2020.4 - 2024.3

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    Authorship:Coinvestigator(s) 

  2. 心臓の硬化を制御するG蛋白質共役受容体の機能解明と心不全治療薬シーズの探索

    Grant number:20H03674  2020.4 - 2023.3

    竹藤 幹人

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    Authorship:Coinvestigator(s) 

    近年、心臓が硬くなり拡がりにくいために症状を呈する「収縮機能が保たれた心不全(HFpEF)」が注目されている。従来の心収縮機能低下を標的とする治療法ではHFpEFの治療効果は乏しく、HFpEFに対する新たな治療法の開発が求められている。adhesion-GPCRファミリーは物理的刺激により活性化されるGPCRとして新たに分類され、メカノストレスに対する生体反応を制御する分子として注目されている。adhesion-GPCR X がHFpEFに関わっていることを明らかにし、その下流で活性化するリン酸化シグナルを解析する。本研究では、HFpEF治療薬の開発シーズを得ることを目指す。

  3. 脂肪組織由来間葉系前駆細胞を用いた血管新生療法の分子基盤探索

    Grant number:20K08401  2020.4 - 2023.3

    柴田 玲

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    Authorship:Coinvestigator(s) 

    「脂肪組織由来間葉系前駆細胞を用いた重症虚血肢に対する血管新生療法」が効果を示す、その機序解明と優位性の評価を行う逆トランスレーショナルリサーチの遂行。具体的には、以下の4点に関して検討を行う。
    1) ADRCsを用いた血管新生療法の治療効果を予測するバイオマーカーの探索
    2) 創傷治癒におけるADRCsの役割検討
    3) ADRCsを用いた血管新生療法の治療効果の機序解明
    4) 生活習慣病がADRCsの血管新生療法へ及ぼす影響の検討

  4. Glucagon-dependent autonomic regulatory system and its role in cardiovascular disease

    Grant number:19H03651  2019.4 - 2022.3

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    Authorship:Coinvestigator(s) 

  5. グルカゴン関連蛋白と毛細血管機能にフォーカスした糖尿病性心筋症の病態に関する研究

    Grant number:18H02805  2018.4 - 2021.3

    室原 豊明

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    Authorship:Principal investigator 

    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

    糖尿病合併心血管病の基本病態は血管障害であり、それらは大血管障害と毛細血管障害に分けられる。毛細血管障害については、予後や患者のQOLに悪影響をもたらすものの、未だに明確な病態が明らかにされておらず治療法も確立されていない。本研究では糖尿病性細小血管傷害による心機能の低下対して、特にインクレチンやグルカゴンと、毛細血管機能、血管新生機能に着目してその病態解明と新しい治療法の開発を目指す。血管新生因子、アディポカイン・マイオカインとの関連性についても検討する。
    (1)グルカゴン、GLP-1 研究
    グルカゴン関連ペプチド (glucagon, GLP-1, GIPなど) は、心筋細胞や血管内皮細胞にも受容体が存在し、直接的効果がある。近年グルカゴン関連ペプチドにより、血管新生を惹起できることが報告されており、グルカゴン関連ペプチドと糖尿病性毛細血管障害の関連性が注目されている。大規模臨床試験でもGLP-1受容体作動薬が心血管イベントを有意に低下させることが示され、その機序について注目が集まっている。我々はグルカゴン・GLP-1欠損マウスを入手し研究を継続した。その結果興味ある知見を得たので、論文投稿中である。
    (2)アディポカイン・マイオカイン研究
    我々のグループはこれまでに新規アディポカイン・マイオカインを複数同定しており、これらが虚血部血管新生作用を有していることもまた報告した。2018年度には新規マイオカインの1つであるマイオネクチンを同定し、その生物学的特性に関して論文発表を行った(Otaka N. et al. Circ. Res. 2018;123:1326-1338.)。心筋虚血再灌流モデルマウスにおいて、マイオネクチンは心筋保護作用を示した。マイオネクチンは運動により骨格筋からの分泌が増強する。これらの研究を現在継続中である。
    アディポカイン・マイオカイン研究においては、新規マイオカインの1つであるマイオネクチンを同定し、その生物学的特性に関して解析を行った(Otaka N. et al. Circ. Res. 2018;123:1326-1338.)。この延長として、心筋梗塞の一般的な動物モデルである、心筋虚血再灌流モデルマウスにおいて、マイオネクチンは心筋保護作用を示した。またマイオネクチンは運動により骨格筋からの分泌が増強することから、非常に興味深い分子である。これらのデータを現在投稿準備中である。
    また、グルカゴン関連ペプチド (glucagon, GLP-1, GIPなど) に関連する研究では、我々はグルカゴン・GLP-1欠損マウスを入手する事が出来て、研究を継続している。糖尿病性心機能障害や毛細血管障害に対するグルカゴン関連ペプチドの役割について研究継続中である。現在は論文作成を終えて、海外雑誌に投稿中である。また学会でもデータを発表している(Nishimura et al. Glucagon acts as a guardian of the heart against catecholamine elevation. 2019年3月 日本循環器学会総会にて発表)。
    引き続き、グルカゴン関連ペプチド(グルカゴンとGLP-1)欠損マウスを用い、心筋虚血モデル、TAC 心不全モデル、血管新生モデルなどを用いて、グルカゴンや GLP-1受容体作動薬剤の心血管系に与える役割を検討して行きたい。また、アディポカイン、マイオカインについても、引き続き動脈硬化モデル、血管新生モデル、心不全モデルなどの動物モデルを用いて、それらの効果を検討して行きたい。
    2020年度から新たに当科において、肺高血圧症モデルマウスを作成する予定である。このモデルにおける血管新生と病態、さらにはグルカゴン関連ペプチド、アディポカイン、マイオカインの効果を見て行きたい。

  6. Role of the novel myokine myonectin in regulation of ischemic heart disease

    Grant number:17H04175  2017.4 - 2020.3

    OUCHI Noriyuki

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    Here we investigated the role of the exercise-induced myokine myonectin in regulation of ischemic heart disease. We found that myonectin knockout mice had increased myocardial infarct size and reduced cardiac function following ischemia-reperfusion compared with control mice, which were accompanied by enhanced apoptosis and inflammatory response in ischemic heart. In contrast, myonectin transgenic mice had reduced ischemia reperfusion injury compared with control mice. Furthermore, myonectin prevented myocardial ischemic injury by reducing cardiomyocyte apoptosis and macrophage inflammatory response through its ability to promote the sphingosine-1-phosphate/cyclicAMP/Akt signaling pathway. Thus, myonectin can function as an exercise-induced myokine which provides cardioprotection.

  7. Role of VEGF165b, an inhibitory vascular endothelial growth factor splice variant, in pulmonary hypertension

    Grant number:17K09551  2017.4 - 2020.3

    Kondo Takahisa

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    Pulmonary hypertension (PH) is a pathophysiological disorder that involves dysregulated proliferation of pulmonary arterial endothelial cells and of smooth muscle cells, resulting in an increase in pulmonary vascular resistance, right-sided heart failure and death. In patients with advanced PH, dysfunctional angiogenesis is one of the main mechanisms of disease progression. Therefore, understanding the balance between angiogenic and antiangiogenic factors is important. In the present study, Role of VEGF165b, an inhibitory vascular endothelial growth factor splice variant, were investigated. In lung disease associated PH (LD-PH), serum levels of VEGF165b were elevated. Among patients with pulmonary arterial hypertension (PAH), serum levels of VEGF165b were elevated in PAH associated with connective tissue disease. VEGF165b may be involved in the pathophysiological disorder of LD-PH and PAH associated with connective tissue disease.

  8. The potential of omentin as therapeutic agents for cardiovascular disease.

    Grant number:17K09572  2017.4 - 2020.3

    Shibata Rei

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    Adipose tissue functions as an endocrine organ by secreting adipokines that can directly affect nearby or remote organs. Omentin is an adipokine whose concentration is down-regulated in subjects with obesity-related disorders. In our study, we have shown that transgenic mice expressing the human omentin gene in fat tissue mice exhibit a significant decrease in mortality and improvement of cardiac function following myocardial infarction. Adipose-derived omentin prevents pathological cardiac remodeling after chronic ischemia, suggesting that omentin represents a potential therapeutic molecule for the treatment of ischemic heart disease.

  9. Functions of Nitric Oxide and Endothelium-derived Hyperpolarizing Factor are impaired in Poor Run-off Autogenous Rabbit Arterial Grafts

    Grant number:17H04290  2017.4 - 2020.3

    KOMORI Kimihiro

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    Background: Vascular endothelium induces smooth muscle cell (SMC) relaxation mainly mediated by endothelium-derived nitric oxide (EDNO) and endothelium-derived hyperpolarizing factor (EDHF). The present study was undertaken to determine whether the functions of EDNO and EDHF might be altered in poor run-off artery graft compared to “non-occluded graft”. Methods: The carotid artery was excised and implanted in its original position as an autogenous graft(“non-occluded graft”), and the most inferior branch of the external carotid artery served as the only outflow for the present conditions (“poor run-off graft”).
    Conclusions: The functions of both EDNO and EDHF are impaired in poor run-off artery grafts.

  10. 脂肪組織由来間葉系前駆細胞を用いた誘導心筋細胞による心筋再生療法の開発

    Grant number:17K09574  2017.4 - 2019.3

    近藤 和久

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    ①我々はまず、脂肪組織由来間葉系幹細胞(ADRC)の心筋分化誘導に必要と考えられる候補因子を次世代シーケンサー(NGS)を用いて検証した。8週の野生型マウスよりADRCを採取・培養しmRNAを抽出、比較対象として2心房2心室が形成される時期であるE10.5の胎児マウス心筋からmRNAを抽出した。NGSの解析をすすめ、最終的に22の因子を候補因子として同定した。この22因子の中には、すでに報告されている心臓線維芽細胞のダイレクトリプログラミングに用いられるGata4、Mef2c、Tbx5(GMT)も含まれることが確認された。
    <BR>
    ②それぞれの転写因子をウイルスベクターに挿入しクロ-ニングを行った。心筋特異的リポーターであるαMHC-GFPトランスジェニックマウスより作成したADRCに、レンチウイルスを用いてADRCへの遺伝子導入を行なった。GMT導入では心筋分化誘導は確認できなかった。次に22の転写因子のうち胎児心筋において発現量の多い上位10遺伝子(Nkx2-5、Hrt2、Gata6、Gata4、Hand2、Mef2a、Baf60c、Tbx20、Klf15、Myocd)を導入したところ、10から14日後にGFP陽性細胞を認める結果が得られたが、陽性細胞の割合は0.1%以下と低く、誘導効率の改善を必要とした。そのため、10因子よりそれぞれ1因子ずつ引いた9因子で比較検証を行ったところ、10因子からHrt2を除いた9因子にてGFP発現が有意に上昇していることを突き止めた。同様の方法で検討を続けたところ、最終的にGata6、Gata4、Mef2a、Baf60c、Klf15、Myocdの6因子で効率が最も良いという結果を得た。

  11. Pathophysiological significance of the Klotho-FGF system in myocardial diseases

    Grant number:16K09429  2016.4 - 2020.3

    Okumura Takahiro

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    We examined the relationship between serum FGF-23 levels and biomarkers, hemodynamics, and prognosis in 42 patients with dilated cardiomyopathy. FGF-23 levels in peripheral vein was negatively correlated with estimated glomerular filtration rate and positively with high-sensitivity troponin T levels. In survival analysis, the cardiac event rate was significantly higher in the High FGF-23 group than in the Low FGF-23 group. In multivariate analysis, the high FGF-23 group was an independent predictor of cardiac events. In multiple regression analysis, the estimated glomerular filtration rate and brain natriuretic peptide levels were significant determinants of FGF-23 levels. Collagen volume fraction in endomyocardial biopsy samples was not significantly correlated with peripheral FGF-23 levels, but was weakly correlated with the transcardiac gradient of FGF-23 levels defined as the difference in concentration between the coronary sinus and the base of the aorta.

  12. Regulation of pathological vascular remodeling by a novel adipocytokines

    Grant number:16K09512  2016.4 - 2019.3

    Ohashi Koji

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    Dysregulation of adipocytokines are involved in the pathogenesis of vascular disease. We previously identified adipolin (APL) as an insulin-sensitizing adipocytokine reduced in obesity. Here, we investigated whether APL modulates pathological vascular remodeling. APL-knockout (KO) and wild-type (WT) mice were subjected to wire-induced injury of the femoral artery. APL-KO mice showed increased neointimal thickening after vascular injury compared with WT mice, which was accompanied by an enhanced inflammatory response and vascular cell proliferation in injured arteries. Treatment of cultured macrophages with APL reduced inflammatory responses, which were reversed by inhibition of TGFβRII/Smad2 signaling. APL also reduced proliferation of vascular smooth muscle cells (VSMCs) through TGFβ/TGFβRII/Smad2-dependent pathway. Our data indicate that APL protects against the development of pathological vascular remodeling by attenuating macrophage inflammatory responses and VSMC proliferation.

  13. Role of aging regulatory protein WRN in cardiac fibrosis

    Grant number:16K09496  2016.4 - 2019.3

    Bando Yasuko K.

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    [Background/Introduction] Aging is known to be one of the primary causes of heart failure. Werner syndrome is one of the aging disorder that caused by dysfunction of DNA helicase-regulatory protein (WRN). [Results] WRN-K577M exhibited diffuse left-ventricular (LV) hypertrophy, enhanced fibrosis, and diastolic LV
    dysfunction with preserved systolic ejection fraction. DNA microarray analysis of WRN-K577M heart revealed that the 253 genes were upregulated including hypertrophy, fibrosis, inflammation, and oxidative stress. Notably, p62 and LC3-II/I were increased in myocardium of WRN-K577M. Blockade of the lysosomal fusion into autophagosome by systemic treatment with chloroquine reduced LC3-II/I ratio.[Conclusion(s)] In WRN-mutant progeria model, off-rate disorder of cardiac autophagy is, at least in part, the cause of increase in oxidative stress and inflammation in heart leading to HFpEF.

  14. Evaluation by Frequency Analysis of Surface Electrocardiogram and Rotor Mapping in Left Atrum

    Grant number:15K09076  2015.4 - 2018.3

    Yasuya Inden

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    Dominant frequency (DF) of atrial fibrillation (AF) reflects atrial electrical activity. We retrospectively investigated 78 patients who underwent catheter ablation due to persistent AF. The high DF of lead aVL and V1 was a predictor of arrhythmia recurrence after persistent AF ablation.
    Electrical rotors may be targets in ablations for persistent atrial fibrillation. Unipolar electrograms in left atrium were recorded with using basket catheter, and we analyzed rotational activities by NavX. rotors were recognized in anterior and posterior LA. We performed PV isolation and delivered RF application to the rotors. AF terminated in some patients and more patients maintained sinus rhythm. Rotors could be able to be recognized by use of basket catheter and EnSite system in patients with persistent AF and may be the target of ablation in persistent AF next to PVI.

  15. 自己脂肪組織由来幹細胞を用いた心血管系再生医療の総合的開発研究

    2014.5 - 2017.3

    科学研究費補助金  基盤研究(B)

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  16. 血管再生障害からみた糖尿病性心筋症の基礎解析と新規治療法の開発         

    2008.5 - 2011.3

    科学研究費補助金  基盤研究(A)

    室原 豊明

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    本研究ではまず血管再生障害からみた糖尿病性心筋症の基礎解析を行った。糖尿病心筋組織標本における心筋毛細血管密度低下には心筋毛細血管に局在するアミノペプチダーゼの活性亢進を介して血管新生関連分子SDF-1α濃度が低下し、その結果Akt・eNOSシグナリング活性低下による血管新生低下が生じることが明らかとなった。以上より、心筋組織におけるアミノペプチダーゼ活性制御は糖尿病性心筋障害の新たな治療方法となる可能性が示唆された。
    Mismatch between cardiomyocyte growth and reduced coronary angiogenesis promotes maladaptive cardiac remodeling including diabetic cardiomyopathy. Diabetes enhances cardiac aminopeptidase activity which promotes degradation in angiogenic chemokine SDF1-α, leading to reduced coronary angiogenesis and resultant cardiac remodeling. Our data suggest that regulation of cardiac aminopepetidase activity may be essential for therapeutic strategy of maladaptive cardiac remodeling in diabetes.

  17. Development of angiogenic cell therapy using iPS cell-derived vascular progenitor cells

    2008.4 - 2013.3

    Grant-in-Aid for Scientific Research 

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  18. 磁場と磁気ナノ粒子を用いた細胞シート工学とその再生医療への応用開発研究

    2007

    科学研究費補助金  萌芽研究,課題番号:19659201

    室原 豊明

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  19. 前駆細胞移植による血管再生療法の分子基盤探索と新規臨床応用に向けた展開研究

    2006.5 - 2008.3

    科学研究費補助金  基盤研究(B)

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  20. バイオペースメーカー細胞の樹立と徐脈性不整脈の細胞治療

    2003.4 - 2005.3

    科学研究費補助金 

    室原 豊明

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    洞不全症候群や完全房室ブロックにおいては、恒久ペースメーカーが体内に植え込まれている。しかしながらペースメーカー本体が高価であり、電池交換を必要とするなど、医療経済的に問題点が多い。近年再生医工学・分子細胞生物学の発展に伴い、心筋・血管再生の研究がなされ成果が出ている。さらに今後は洞結節や房室結節などの自動能を持つ刺激伝導系と異なり、通常は自動能を持たない心室筋細胞も遺伝子治療により自動能を持ち、自律的に心臓を収縮させることが可能であることが報告されている。本研究では、(1)遺伝子導入による心室筋細胞からの洞結節様機能細胞の樹立、ならびに(2)自己骨髄間質細胞からの洞結節様機能細胞の樹立を試みる。本研究の目的は、心房筋や心室筋が自動能を持つようになるメカニズムに関して、遺伝子導入により引き起こされるイオンチャネル、ギャップジャンクション等の電気生理学的な変化を検討することである。さらに実験動物において、遺伝子導入による心筋の自動能発現が、徐脈性不整脈に対する治療法として有効か否かを検討することである。今回はラット新生児心筋細胞を行う。生後1日の新生児ラットより心室筋細胞をトリプシン処理にて単離する。細胞は10%ウシ胎児血清存在下のDMEMにて培養、および拡張(cell expansion)する。当初の予定では、dominant negative Kir2.1(dn-Kir2.1)センダイウイルス遺伝子ベクターを開発し、培養心筋細胞に遺伝子導入を試みる予定であったが、センダイウイルス遺伝子ベクターの安全性が定まらないこと、海外においてこのベクターの応用実績が無いこと、したがって臨床応用や産業化の目途が今のところ立たないことなどが明らかにされてきた。そこで我々は予定を変更し、アデノ随伴ウイルス(AAV)によるdn-Kir2.1遺伝子導入を試みている。dn-Kir2.1アデノ随伴ウイルスベクターは、名古屋大学環境医学研究所、李博士、タフツ大学聖エリザベス医療センターの相川助教授らとの共同研究で行っている。今年度は遺伝子ベクターの開発に予想以上に時間を要し、現在も作成段階にある。今後は作成した遺伝子導入心室筋細胞に対してパッチクランプ法を用い、洞結節型の脱分極反応を示すか否かを検討する。最終的には、これらの細胞移植により、人工ペースメーカーとしての機能を有するか否かについて検討する予定である。

  21. 細胞移植による血管新生療法の改良型開発のための基礎研究

    2002 - 2003

    科学研究費補助金  基盤研究(B)

    室原豊明

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  22. 内皮前駆細胞移植を応用した虚血心筋の血管新生療法の開発

    2000.5 - 2005.3

    科学研究費補助金  特定領域研究

    室原 豊明

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    内皮前駆細胞(EPC)は、CD34を陽性に持つ血球系未分化幹細胞と起源を等しくすると考えられ、末梢血以外にも骨髄や臍帯血から培養・採取可能である。我々はこれまでに、ヒト臍帯血から内皮前駆細胞を得ることに成功し、さらにこれらの細胞を免疫抑制動物の虚血骨格筋内へ移植することにより、血管新生や側副血行路の発達が促されることを確認した。また成人においては、内皮前駆細胞は唯一の造血臓器である骨髄に由来する。我々は2000年より国内多施設共同研究として、重症閉塞性動脈硬化症・Buerger病患者に対する自己骨髄細胞移植による血管新生療法を開始しており良好な成績を得ている(TACT study)。この成果は、2003年6月に再生医学領域では日本初の高度先進医療・保険適応として厚生労働省より認定され今日に至っている。我々は内皮前駆細胞や自己骨髄単核球細胞移植による血管新生療法について引き続き検討を加えている。本年度は、2002年から研究代表者が新しく移籍した名古屋大学医学部附属病院においても、自己骨髄細胞移植による血管再生療法の臨床応用を開始した(重症末梢動脈閉塞症患者に対して)。既にこれまでに7例の治療を完了しており、効果も複数例で認められている。2003年度の11月には、自己骨髄単核救細胞移植による重症末期狭心症患者への血管再生療法のプロトコールも名古屋大学医学部倫理委員会に承認されており、2004年の後半にこの治療を開始した。基礎研究面では、移植前の内皮前駆細胞に低酸素負荷を与えると細胞機能が活性化され、移植後の血管新生効果が増強されることが確認された。また、機械的刺激によっても細胞の血管新生機能が活性化されることが明らかとなった。さらに細胞移植とAngiopoietin-1(Ang-1)遺伝子治療との併用により、より少ない骨髄細胞によっても同程度の血管新生効果が得られることが我々の基礎研究より明らかとなった。これ以外にも、降圧剤として汎用されているACE阻害剤やAngiotensin II 1型受容体拮抗剤が腫瘍の増殖や増殖性糖尿病性網膜症の増悪を軽減させたとの実験結果に着目し、これらの効果が血管新生の抑制を介していることを実験的に確認した。さらにVEGF-E/PIGFキメラ遺伝子が、VEGF-A遺伝子と同程度に虚血部位の血流を改善させることが判明した。今後これらのキメラ遺伝子と骨髄細胞の併用療法を考察していく。

  23. 末梢血幹細胞移植を応用した新しい虚血部血管新生療法の開発

    2000.5 - 2002.3

    科学研究費補助金  基盤研究(B)

    室原豊明

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    近年、内皮前駆細胞が成人においても存在することが確認され、さらにこれらの細胞は成人における血管新生に参加することが示された。我々はこれらの細胞を虚血組織に移植することで、血管新生が有意に増強されることを報告した。実際にこの治療を臨床に応用する場合、自己の内皮前駆細胞を使用することが理想的であるが、細胞の採取(骨髄)には侵襲を伴い問題が残る。内皮前駆細胞と血球系幹細胞は起源を一つにすることから、本研究では血球系幹細胞を動員するコロニー刺激因子(rhG-CSF)が内皮前駆細胞の動員を介して血管新生を増強できないか否かを、動物実験において検討した。
    1)rhG-CSF(5μg/kg BW/d)背部皮下投与後、ラット末梢血白血球数は有意に増加させ、中止後は再び正常値に復帰した。従って、ラットにおいてfunctionalであった。末梢血単核球培養法において、細胞クラスター(コロニー)は十分に形成されたが、内皮前駆細胞様-細胞の発芽はむしろ抑制された。
    2)ラット背部皮下にrhG-CSF(5μg/kg BW/d)を7日間連続投与した群(rhG-CSF群)においては、血管新生の程度にコントロール群と有意な差は出なかった。
    rhG-CSFによる末梢血への幹細胞動員においては、共通の幹細胞から顆粒球系への分化が主に進み、内皮前駆細胞の分化や動員はむしろ抑制されるのではないかと思われた。rhG-CSFにより末梢血への内皮前駆細胞の動員が刺激されなくとも、虚血下肢における血管新生には影響が無かったことより、少なくともこのモデルに関しては流血中の内皮前駆細胞の血管新生における関与は比較的少ないのではないか。
    我々はさらに、細胞移植前の細胞虚血負荷が血管新生増強効果を有するか否かについて検討を加えた。この結果、内皮前駆細胞を移植前に虚血環境で培養したものは、しなかった細胞に比べて、血管新生効果が有意に大であった。

  24. コロニー刺激因子を用いた新しい虚血部血管新生療法の開発-内皮前駆細胞動員療法-

    2000.5 - 2001.3

    科学研究費補助金  特定領域研究

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    Authorship:Principal investigator 

  25. 血管新生と血管保護療法の開発に関する研究

    2000 - 2004

    科学研究費補助金  厚生労働省厚生労働科学研究費補助金(ヒトゲノム・再生医療等研究事業)

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    Authorship:Coinvestigator(s) 

  26. ヒト臍帯血からの内皮前駆細胞単離および分化誘導と血管新生療法への応用

    1999.5 - 2001.3

    科学研究費補助金  基盤研究(B)

    室原豊明

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    Authorship:Principal investigator 

  27. 自己骨髄単核細胞移植による心筋梗塞後血管新生療法の実験的試み

    1999.5 - 2000.3

    科学研究費補助金  特定領域研究

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    Authorship:Principal investigator 

    従来成人における血管新生は、既存の内皮細胞の増殖と遊走にするもののみであると考えられてきたが、我々は最近成人末梢血中の単核球分画に血管内皮細胞に分化しうる内皮前駆細胞が存在することを報告した。内皮前駆細胞はCD34陽性細胞由来と考えられ、培養過程で血管内皮細胞の形質を獲得した。また内皮前駆細胞を標識しヒト内皮細胞と共培養すると、マトリゲル上で管腔形成に組み込まれることが示された。さらに、動物に経静脈的に投与すると、虚血下肢の血管新生に組み込まれることが明らかとなった。以上より成人における血管新生には、既存の毛細血管内皮細胞の増殖と遊走のみではなく、流血中の内皮前駆細胞の分化という血管形成型の血管新生も関与する可能性があることが示された。
    成人における内皮前駆細胞は骨髄由来であると考えられる。今回我々は、動物実験系(ウサギ片側下肢虚血モデル)において、蛍光色素ラベルした自己骨髄単核球細胞を直接虚血骨格筋内に植え込むことによって虚血部位における血管新生に自己内皮前駆細胞が組み込まれことを確認した。また、骨髄単核球を自己移植投与することによって、虚血骨格筋内における血管新生や血流が改善されることを確認した。方法として、下腿血圧左右比、血管造影による血管スコアの算定、虚血組織標本における免疫染色による内皮細胞の同定と毛細血管密度の算定、レーザードップラー法による皮下血流の計測を用いた。以上より、自己骨髄細胞の移植はによって、虚血骨格筋内の血管新生を有意に増強させうることが示された。

  28. 高脂血症における組織虚血後の血管新生に関する研究

    1998.5 - 1999.3

    科学研究費補助金  科学研究費補助金 奨励研究 A

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    Authorship:Principal investigator 

    血管新生並びに側副血行路の形成は、虚血組織の血液灌流を維持するために重要な生理反応の一つである。我々はこれまでに、内皮由来一酸化窒素(NO)が欠損した状態では、虚血組織の血管新生が著しく抑制されていることを報告してきた。内皮由来NOが血管新生に重要な役割を果たしているという事実を考慮すれば、高脂血症患者ないしは高脂血症モデル動物においては、血管内皮機能が低下し、内皮由来NOの産生が減弱し、その結果組織虚血に引き続く血管新生反応が障害されている可能性が考えられる。我々は高脂血症モデルラットを作成し、片側下肢虚血モデルにおいての血管新生について、in vivoで検討を加えた。その結果、(a)虚血下肢における血管新生は、正常ラットに比べ高脂血症ラットにおいて障害されていた。評価方法として、レーザードップラー法による下肢血流測定、血管造影検査による血管スコアーの算出、摘出虚血組織における内皮細胞の免疫染色による同定および毛細血管密度の算定を用いた。(b)高脂血症ラットにおいては、実際に虚血組織中並びに血中のNOxの量が低下していた。また組織中のcGMP量も減弱していた。反面組織中の内因性NO不活性化物質ADMA量の増加がみられた。(c)内因性NOの前駆体であるL-arginineの経口投与によって、高脂血症ラットの障害された血管新生が改善された。(d)血管新生を惹起する内因性の成長因子、特にVEGFの発現の程度は、高脂血症ラットとコントロールラットでは差がなかった。以上より、高脂血症において、血管新生が減弱していること、並びに内因性のNOの減弱が関与していることが明らかにされた。

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Industrial property rights 1

  1. Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue.

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    Patent/Registration no:United States Patent: 6,878,371  Date registered:2005.4 

    Country of applicant:Foreign country