Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction

Farshadyeganeh, P; Nazim, M; Zhang, RC; Ohkawara, B; Nakajima, K; Rahman, MA; Nasrin, F; Ito, M; Takeda, JI; Ohe, K; Miyasaka, Y; Ohno, T; Masuda, A; Ohno, K

ISCIENCE   Vol. 26 ( 10 ) page： 107746   2023.10

FexSplice: A LightGBM-Based Model for Predicting the Splicing Effect of a Single Nucleotide Variant Affecting the First Nucleotide G of an Exon

Joudaki, A; Takeda, J; Masuda, A; Ode, R; Fujiwara, K; Ohno, K

GENES   Vol. 14 ( 9 )   2023.9

Interactions between muscle glucose homeostasis and neuromuscular signal transduction - Lessons learned from lack of a muscle-specific long isoform of GFPT1

Farshadyeganeh, P; Nazim, M; Ohkawara, B; Masuda, A; Ito, M; Takeda, J; Ohe, K; Ohno, K

EUROPEAN JOURNAL OF HUMAN GENETICS   Vol. 31   page： 31 - 31   2023.5

Neural Isoforms of Agrin Are Generated by Reduced PTBP1-RNA Interaction Network Spanning the Neuron-Specific Splicing Regions in <i>AGRN</i>

Bushra, S; Lin, YN; Joudaki, A; Ito, M; Ohkawara, B; Ohno, K; Masuda, A

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 24 ( 8 )   2023.4

Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria Reviewed

Takuro Toda, Mikako Ito, Jun-ichi Takeda, Akio Masuda, Hiroyuki Mino, Nobutaka Hattori, Kaneo Mohri, Kinji Ohno

communications biology   Vol. 5 ( 1 ) page： 453   2022.5

Prediction of the splicing effects of SNVs affecting the first nucleotide G of an exon Reviewed

Joudaki, A; Takeda, J; Masuda, A; Ohno, K

EUROPEAN JOURNAL OF HUMAN GENETICS   Vol. 30 ( SUPPL 1 ) page： 498 - 498   2022.4

Meclozine ameliorates skeletal muscle pathology and increases muscle forces in<i> mdx</i> mice

Kawamura, Y; Hida, T; Ohkawara, B; Matsushita, M; Kobayashi, T; Ishizuka, S; Hiraiwa, H; Tanaka, S; Tsushima, M; Nakashima, H; Ito, K; Imagama, S; Ito, M; Masuda, A; Ishiguro, N; Ohno, K

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 592   page： 87 - 92   2022.2

tRIP-seq法を用いた微量検体からのRNA修飾部位検出 Invited

増田章男、河地利彦、大野欽司

細胞   Vol. 53 ( 14 ) page： 918 - 920   2021.12

Regulated splicing of large exons is linked to phase-separation of vertebrate transcription factors Reviewed

Kawachi, T; Masuda, A; Yamashita, Y; Takeda, J; Ohkawara, B; Ito, M; Ohno, K

EMBO JOURNAL   Vol. 40 ( 22 ) page： e107485   2021.11

Zonisamide upregulates neuregulin-1 expression and enhances acetylcholine receptor clustering at the in vitro neuromuscular junction Reviewed

Inoue, T; Ohkawara, B; Bushra, S; Kanbara, S; Nakashima, H; Koshimizu, H; Tomita, H; Ito, M; Masuda, A; Ishiguro, N; Imagama, S; Ohno, K

NEUROPHARMACOLOGY   Vol. 195   page： 108637   2021.9

Rapidly Growing Protein-Centric Technologies to Extensively Identify Protein-RNA Interactions: Application to the Analysis of Co-Transcriptional RNA Processing Reviewed

Masuda, A; Kawachi, T; Ohno, K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 10 )   2021.5

Zonisamide ameliorates neuropathic pain partly by suppressing microglial activation in the spinal cord in a mouse model Reviewed

Koshimizu, H; Ohkawara, B; Nakashima, H; Ota, K; Kanbara, S; Inoue, T; Tomita, H; Sayo, A; Kiryu-Seo, S; Konishi, H; Ito, M; Masuda, A; Ishiguro, N; Imagama, S; Kiyama, H; Ohno, K

LIFE SCIENCES   Vol. 263   page： 118577   2020.12

Gene Expression Profile at the Motor Endplate of the Neuromuscular Junction of Fast-Twitch Muscle Reviewed

Huang, K; Li, J; Ito, M; Takeda, JI; Ohkawara, B; Ogi, T; Masuda, A; Ohno, K

FRONTIERS IN MOLECULAR NEUROSCIENCE   Vol. 13   page： 154   2020.9

CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction Reviewed

Ohkawara, B; Kobayakawa, A; Kanbara, S; Hattori, T; Kubota, S; Ito, M; Masuda, A; Takigawa, M; Lyons, KM; Ishiguro, N; Ohno, K

EMBO REPORTS   Vol. 21 ( 8 ) page： e48462   2020.8

Zonisamide ameliorates progression of cervical spondylotic myelopathy in a rat model Reviewed

Kanbara, S; Ohkawara, B; Nakashima, H; Ohta, K; Koshimizu, H; Inoue, T; Tomita, H; Ito, M; Masuda, A; Ishiguro, N; Imagama, S; Ohno, K

SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page： 13138   2020.8

tRIP-seq reveals repression of premature polyadenylation by co-transcriptional FUS-U1 snRNP assembly Reviewed

Masuda, A; Kawachi, T; Takeda, J; Ohkawara, B; Ito, M; Ohno, K

EMBO REPORTS   Vol. 21 ( 5 ) page： e49890   2020.5

SRSF3 and hnRNP K Antagonistically Regulate Splicing of Large Exons Reviewed

Kawachi, T; Masuda, A; Takeda, J; Ito, M; Hamaguchi, T; Ohno, K

FASEB JOURNAL   Vol. 34   2020.4

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair Reviewed

Nakazawa, Y; Hara, Y; Oka, Y; Komine, O; van den Heuvel, D; Guo, CW; Daigaku, Y; Isono, M; He, YX; Shimada, M; Kato, K; Jia, N; Hashimoto, S; Kotani, Y; Miyoshi, Y; Tanaka, M; Sobue, A; Mitsutake, N; Suganami, T; Masuda, A; Ohno, K; Nakada, S; Mashimo, T; Yamanaka, K; Luijsterburg, MS; Ogi, T

CELL   Vol. 180 ( 6 ) page： 1228 - +   2020.3

Author Correction: Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis.

Okura T, Ohkawara B, Takegami Y, Ito M, Masuda A, Seki T, Ishiguro N, Ohno K

Scientific reports   Vol. 10 ( 1 ) page： 2995   2020.2

Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes <i>Mbnl1</i> transcription in myogenic cells

Huang, K; Masuda, A; Chen, GY; Bushra, S; Kamon, M; Araki, T; Kinoshita, M; Ohkawara, B; Ito, M; Ohno, K

SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page： 2558   2020.2

Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis

Okura, T; Ohkawara, B; Takegami, Y; Ito, M; Masuda, A; Seki, T; Ishiguro, N; Ohno, K

SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page： 2808   2019.2

Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction

Li Jin, Ito Mikako, Ohkawara Bisei, Masuda Akio, Ohno Kinji

SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page： 13577   2018.9

Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters Reviewed

Ito Kenyu, Ohkawara Bisei, Yagi Hideki, Nakashima Hiroaki, Tsushima Mikito, Ota Kyotaro, Konishi Hiroyuki, Masuda Akio, Imagama Shiro, Kiyama Hiroshi, Ishiguro Naoki, Ohno Kinji

SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page： 434   2018.1

MYRF Is Associated with Encephalopathy with Reversible Myelin Vacuolization

Kurahashi Hirokazu, Azuma Yoshiteru, Masuda Akio, Okuno Tatsuya, Nakahara Eri, Imamura Takuji, Saitoh Makiko, Mizuguchi Masashi, Shimizu Toshiaki, Ohno Kinji, Okumura Akihisa

ANNALS OF NEUROLOGY   Vol. 83 ( 1 ) page： 98 - 106   2018.1

Rules and tools to predict the splicing effects of exonic and intronic mutations

Ohno Kinji, Takeda Jun-ichi, Masuda Akio

WILEY INTERDISCIPLINARY REVIEWS-RNA   Vol. 9 ( 1 )   2018.1

Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/beta-catenin signaling

Miyamoto Kentaro, Ohkawara Bisei, Ito Mikako, Masuda Akio, Hirakawa Akihiro, Sakai Tadahiro, Hiraiwa Hideki, Hamada Takashi, Ishiguro Naoki, Ohno Kinji

PLOS ONE   Vol. 12 ( 9 ) page： e0184388   2017.9

SRSF1 suppresses selection of intron-distal 5 ' splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein

Bin Ahsan Khalid, Masuda Akio, Rahman Mohammad Alinoor, Takeda Jun-ichi, Nazim Mohammad, Ohkawara Bisei, Ito Mikako, Ohno Kinji

SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page： 10446   2017.9

Splicing regulation and dysregulation of cholinergic expressed at the neuromuscular junction

Ohno Kinji, Rahman Mohammad Alinoor, Nazim Mohammad, Nasrin Farhana, Lin Yingni, Takeda Jun-ichi, Masuda Akio

JOURNAL OF NEUROCHEMISTRY   Vol. 142   page： 64 - 72   2017.8

Splicing regulation of the human acetylcholinesterase gene

Ohno Kinji, Nazim Mohammad, Masuda Akio

JOURNAL OF NEUROCHEMISTRY   Vol. 142   page： 198 - 198   2017.8

Wnt/beta-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells

Kishimoto Yasuzumi, Ohkawara Bisei, Sakai Tadahiro, Ito Mikako, Masuda Akio, Ishiguro Naoki, Shukunami Chisa, Docheva Denitsa, Ohno Kinji

PLOS ONE   Vol. 12 ( 7 ) page： e0182051   2017.7

Six GU-rich (6GU(R)) FUS-binding motifs detected by normalization of CLIP-seq by Nascent-seq

Takeda Jun-Ichi, Masuda Akio, Ohno Kinji

GENE   Vol. 618   page： 57 - 64   2017.6

Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms

Nazim Mohammad, Masuda Akio, Rahman Mohammad Alinoor, Nasrin Farhana, Takeda Jun-Ichi, Ohe Kenji, Ohkawara Bisei, Ito Mikako, Ohno Kinji

NUCLEIC ACIDS RESEARCH   Vol. 45 ( 3 ) page： 1455 - 1468   2017.2

Splicing regulation and dysregulation of cholinergic genes expressed at the neuromuscular junction Invited Reviewed

Ohno K, Rahman MA, Nazim M, Nasrin F, Lin Y, Takeda J, Masuda A

J Neurochem   Vol. 142   page： 64-72   2017

FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis. Reviewed

Masuda A, Takeda J, Ohno K

Wiley interdisciplinary reviews. RNA   Vol. 7 ( 3 ) page： 330-40   2016.5

Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters. Reviewed

Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, Ishiguro N, Ohno K

Biochemical and biophysical research communications   Vol. 470 ( 2 ) page： 356-61   2016.2

Arginine methylation of ubiquitin-associated protein 2-like is required for the accurate distribution of chromosomes. Reviewed

Maeda M, Hasegawa H, Sugiyama M, Hyodo T, Ito S, Chen D, Asano E, Masuda A, Hasegawa Y, Hamaguchi M, Senga T

FASEB journal : official publication of the Federation of American Societies for Experimental Biology   Vol. 30 ( 1 ) page： 312-23   2016.1

Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy Reviewed

Chen, G. Masuda, A. Konishi, H. Ohkawara, B. Ito, M. Kinoshita, M. Kiyama, H. Matsuura, T. Ohno, K.

Sci Rep.   Vol. 6   page： 25317   2016

Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis. Reviewed

Mishima K, Kitoh H, Ohkawara B, Okuno T, Ito M, Masuda A, Ishiguro N, Ohno K

EBioMedicine   Vol. 2 ( 12 ) page： 2046-61   2015.11

Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model. Reviewed

Yagi H, Ohkawara B, Nakashima H, Ito K, Tsushima M, Ishii H, Noto K, Ohta K, Masuda A, Imagama S, Ishiguro N, Ohno K

PloS one   Vol. 10 ( 11 ) page： e0142786   2015.11

Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling. Reviewed

Otsuka K, Ito M, Ohkawara B, Masuda A, Kawakami Y, Sahashi K, Nishida H, Mabuchi N, Takano A, Engel AG, Ohno K

Scientific reports   Vol. 5   page： 13928   2015.9

SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome. Reviewed

Rahman MA, Azuma Y, Nasrin F, Takeda J, Nazim M, Bin Ahsan K, Masuda A, Engel AG, Ohno K

Scientific reports   Vol. 5   page： 13208   2015.8

A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space. Reviewed

Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K

Neuromuscular disorders : NMD   Vol. 25 ( 8 ) page： 667-71   2015.8

Position-specific binding of FUS to nascent RNA regulates mRNA length Reviewed

Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, Ishigaki S, Sobue G, Ohno K

Genes & development   Vol. 29 ( 10 ) page： 1045-57   2015.5

Meclozine Promotes Longitudinal Skeletal Growth in Transgenic Mice with Achondroplasia Carrying a Gain-of-Function Mutation in the FGFR3 Gene.

    2015.2

Congenital myasthenic syndrome in Japan: Ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits.

Azuma Y, Nakata T, Tanaka M, Shen XM, Ito M, Iwata S, Okuno T, Nomura Y, Ando N, Ishigaki K, Ohkawara B, Masuda A, Natsume J, Kojima S, Sokabe M, Ohno K.

Neuromuscul Disord.     2015.1

A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space

Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K

Neuromuscul Disord     page： 667-71   2015

Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells Reviewed

Sato N, Maeda M, Sugiyama M, Ito S, Hyodo T, Masuda A, Tsunoda N, Kokuryo T, Hamaguchi M, Nagino M, Senga T

Cancer Med   Vol. 4 ( 2 ) page： 268-77   2015

HnRNP C, YB-1 and hnRNP L coordinately enhance skipping of human MUSK exon 10 to generate a Wnt-insensitive MuSK isoform.

Nasrin F, Rahman MA, Masuda A, Ohe K, Takeda J, Ohno K.

Sci Rep.     2014.10

LRP4 induces extracellular matrix productions and facilitates chondrocyte differentiation.

Asai N, Ohkawara B, Ito M, Masuda A, Ishiguro N, Ohno K.

Biochem Biophys Res Commun.     2014.8

Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling Reviewed

Takamatsu, A. and Ohkawara, B. and Ito, M. and Masuda, A. and Sakai, T. and Ishiguro, N. and Ohno, K.

PLOS ONE     page： in press   2014

LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated musk signaling in a position-specific manner Reviewed

Ohkawara, B. and Cabrera-Serrano, M. and Nakata, T. and Milone, M. and Asai, N. and Ito, K. and Ito, M. and Masuda, A. and Ito, Y. and Engel, A. G. and Ohno, K.

Hum Mol Genet     page： in press   2014

HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA Reviewed

Rahman, M. A. and Masuda, A. and Ohe, K. and Ito, M. and Hutchinson, D. O. and Mayeda, A. and Engel, A. G. and Ohno, K.

Sci Rep   Vol. 3   page： 2931   2013

Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice Reviewed

Yamamoto, R. and Matsushita, M. and Kitoh, H. and Masuda, A. and Ito, M. and Katagiri, T. and Kawai, T. and Ishiguro, N. and Ohno, K.

J Bone Miner Metab   Vol. 31 ( 1 ) page： 26-33   2013

Mutations in the C-Terminal Domain of ColQ in Endplate Acetylcholinesterase Deficiency Compromise ColQ-MuSK Interaction Reviewed

Nakata, T. and Ito, M. and Azuma, Y. and Otsuka, K. and Noguchi, Y. and Komaki, H. and Okumura, A. and Shiraishi, K. and Masuda, A. and Natsume, J. and Kojima, S. and Ohno, K.

Hum Mutat   Vol. 34 ( 7 ) page： 997-1004   2013

The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons Reviewed

Honda, D. and Ishigaki, S. and Iguchi, Y. and Fujioka, Y. and Udagawa, T. and Masuda, A. and Ohno, K. and Katsuno, M. and Sobue, G.

FEBS Open Bio   Vol. 4   page： 1-10   2013

FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD Reviewed

Fujioka, Y. and Ishigaki, S. and Masuda, A. and Iguchi, Y. and Udagawa, T. and Watanabe, H. and Katsuno, M. and Ohno, K. and Sobue, G.

Sci Rep   Vol. 3   page： 2388   2013

Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia Reviewed

Matsushita, M. and Kitoh, H. and Ohkawara, B. and Mishima, K. and Kaneko, H. and Ito, M. and Masuda, A. and Ishiguro, N. and Ohno, K.

PLoS ONE   Vol. 8 ( 12 ) page： e81569   2013

Four parameters increase the sensitivity and specificity of the exon array analysis and disclose 25 novel aberrantly spliced exons in myotonic dystrophy Reviewed

Yamashita, Y. and Matsuura, T. and Shinmi, J. and Amakusa, Y. and Masuda, A. and Ito, M. and Kinoshita, M. and Furuya, H. and Abe, K. and Ibi, T. and Sahashi, K. and Ohno, K.

J Hum Genet   Vol. 57 ( 6 ) page： 368-74   2012

Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions Reviewed

Ishigaki, S. and Masuda, A. and Fujioka, Y. and Iguchi, Y. and Katsuno, M. and Shibata, A. and Urano, F. and Sobue, G. and Ohno, K.

Sci Rep   Vol. 2   page： 529   2012

CUGBP1 and MBNL1 preferentially bind to 3' UTRs and facilitate mRNA decay Reviewed

Masuda, A. and Andersen, H. S. and Doktor, T. K. and Okamoto, T. and Ito, M. and Andresen, B. S. and Ohno, K.

Sci Rep   Vol. 2   page： 209   2012

Protein-anchoring strategy for delivering acetylcholinesterase to the neuromuscular junction Reviewed

Ito, M. and Suzuki, Y. and Okada, T. and Fukudome, T. and Yoshimura, T. and Masuda, A. and Takeda, S. and Krejci, E. and Ohno, K.

Mol Ther   Vol. 20 ( 7 ) page： 1384-92   2012

AG-dependent 3'-splice sites are predisposed to aberrant splicing due to a mutation at the first nucleotide of an exon Reviewed

Fu, Y. and Masuda, A. and Ito, M. and Shinmi, J. and Ohno, K.

Nucleic Acids Res   Vol. 39 ( 10 ) page： 4396-404   2011

Anti-MuSK autoantibodies block binding of collagen Q to MuSK Reviewed

Kawakami, Y. and Ito, M. and Hirayama, M. and Sahashi, K. and Ohkawara, B. and Masuda, A. and Nishida, H. and Mabuchi, N. and Engel, A. G. and Ohno, K.

Neurology   Vol. 77 ( 20 ) page： 1819-26   2011

Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8 Reviewed

Kaneko, H. and Kitoh, H. and Matsuura, T. and Masuda, A. and Ito, M. and Mottes, M. and Rauch, F. and Ishiguro, N. and Ohno, K.

Hum Genet   Vol. 130 ( 5 ) page： 671-83   2011

プロトタイプシナプスとしての神経筋接合部の病態と治療戦略

大野欽司、伊藤美佳子、増田章男

日本神経精神薬理学雑誌   Vol. 29 ( 4 ) page： 145-151   2009

Tannic acid facilitates expression of the polypyrimidine tract binding protein and alleviates deleterious inclusion of CHRNA1 exon P3A due to an hnRNP H-disrupting mutation in congenital myasthenic syndrome Reviewed

Bian, Y. and Masuda, A. and Matsuura, T. and Ito, M. and Okushin, K. and Engel, A. G. and Ohno, K.

Hum Mol Genet   Vol. 18 ( 7 ) page： 1229-37   2009

Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells Reviewed

Itoh, T. and Fujita, Y. and Ito, M. and Masuda, A. and Ohno, K. and Ichihara, M. and Kojima, T. and Nozawa, Y. and Ito, M.

Biochem Biophys Res Commun   Vol. 389 ( 4 ) page： 651-6   2009

Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease Reviewed

Fu, Y. and Ito, M. and Fujita, Y. and Ito, M. and Ichihara, M. and Masuda, A. and Suzuki, Y. and Maesawa, S. and Kajita, Y. and Hirayama, M. and Ohsawa, I. and Ohta, S. and Ohno, K.

Neuroscience Letters   Vol. 453   page： 81–85   2009

hnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndrome Reviewed

Masuda, A. and Shen, X. M. and Ito, M. and Matsuura, T. and Engel, A. G. and Ohno, K.

Hum Mol Genet   Vol. 17 ( 24 ) page： 4022-4035   2008

Viral vector-medicated expression of human collagen Q in cultured cells Reviewed

Ito, M. and Masuda, A. and Jinno, S. and Katagiri, T. and Krejci, E. and Ohno, K.

Chem Biol Interact   Vol. 175 ( 1-3 ) page： 346-348   2008

Human branch point consensus sequence is yUnAy Reviewed

Gao, K. and Masuda, A. and Matsuura, T. and Ohno, K.

Nucleic Acids Res   Vol. 36 ( 7 ) page： 2257-2267   2008

In vitro and in silico analysis reveals an efficient algorithm to predict the splicing consequences of mutations at the 5' splice sites Reviewed

Sahashi, K. and Masuda, A. and Matsuura, T. and Shinmi, J. and Zhang, Z. and Takeshima, Y. and Matsuo, M. and Sobue, G. and Ohno, K.

Nucleic Acids Res   Vol. 35 ( 18 ) page： 5995-6003   2007

Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells Reviewed

Chiba, N. and Masuda, A. and Yoshikai, Y. and Matsuguchi, T.

J Cell Physiol   Vol. 213 ( 1 ) page： 126-36   2007

Essential role of GATA transcriptional factors in the activation of mast cells Reviewed

Masuda, A. and Hashimoto, K. and Yokoi, T. and Doi, T. and Kodama, T. and Kume, H. and Ohno, K. and Matsuguchi, T.

J Immunol   Vol. 178 ( 1 ) page： 360-368   2007

Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities Reviewed

Ichihara, M. and Murakumo, Y. and Masuda, A. and Matsuura, T. and Asai, N. and Jijiwa, M. and Ishida, M. and Shinmi, J. and Yatsuya, H. and Qiao, S. and Takahashi, M. and Ohno, K.

Nucleic Acids Res   Vol. 35 ( 18 ) page： e123   2007

Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling Reviewed

Musikacharoen, T. and Oguma, A. and Yoshikai, Y. and Chiba, N. and Masuda, A. and Matsuguchi, T.

Blood   Vol. 105 ( 2 ) page： 711-720   2005

A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation Reviewed

Sugimoto, K. and Ohata, M. and Miyoshi, J. and Ishizaki, H. and Tsuboi, N. and Masuda, A. and Yoshikai, Y. and Takamoto, M. and Sugane, K. and Matsuo, S. and Shimada, Y. and Matsuguchi, T.

J Clin Invest   Vol. 114 ( 6 ) page： 857-866   2004

The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells Reviewed

Masuda, A. and Yoshikai, Y. and Kume, H. and Matsuguchi, T.

J Immunol   Vol. 173 ( 9 ) page： 5564-5573   2004

Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated mice Reviewed

Abe, T. and Arai, T. and Ogawa, A. and Hiromatsu, T. and Masuda, A. and Matsuguchi, T. and Nimura, Y. and Yoshikai, Y.

Hepatology   Vol. 40 ( 2 ) page： 414-423   2004

LPS刺激によるマスト細胞からのサイトカイン産生機構におけるセラミドの役割

千葉紀香、増田章男、松口徹也

アレルギー科   Vol. 15 ( 3 ) page： 220-227   2003

Toll like receptorを介するマスト細胞の活性化

増田章男、松口徹也

臨床免疫   Vol. 39 ( 6 ) page： 633-637   2003

JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation Reviewed

Matsuguchi, T. and Masuda, A. and Sugimoto, K. and Nagai, Y. and Yoshikai, Y.

Embo J   Vol. 22 ( 17 ) page： 4455-4464   2003

Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways Reviewed

Masuda, A. and Yoshikai, Y. and Aiba, K. and Matsuguchi, T.

J Immunol   Vol. 169 ( 7 ) page： 3801-3810   2002

Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression Reviewed

Masuda, A. and Matsuguchi, T. and Yamaki, K. and Hayakawa, T. and Yoshikai, Y.

J Biol Chem   Vol. 276 ( 28 ) page： 26107-26113   2001

Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling Reviewed

Iwami, K. I. and Matsuguchi, T. and Masuda, A. and Kikuchi, T. and Musikacharoen, T. and Yoshikai, Y.

J Immunol   Vol. 165 ( 12 ) page： 6682-6686   2000

Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells Reviewed

Masuda, A. and Matsuguchi, T. and Yamaki, K. and Hayakawa, T. and Kubo, M. and LaRochelle, W. J. and Yoshikai, Y.

J Biol Chem   Vol. 275 ( 38 ) page： 29331-29337   2000

Activation of mast cells through toll like receptors

Akio Masuda, Tetsuya Matsuguchi（ Role： Joint author）

2003.6 

The splicing mechanism that secures large exons encoding intrinsic disordered regions of transcription factors International conference

Toshihiko Kawachi Akio Masuda, Jun-ichi Takeda, Mikako Ito, Tomonari Hamaguchi, Kinji Ohno

Experimental Biology 2020 Meeting  2020.4  Federation of American Societies for Experimental Biology

Identification of U1 snRNP-FUS-RNA interactome co-transcriptionally assembled on RNA polymerase II by targeted RNA immunoprecipitation (tRIP

Akio Masuda, Toshihiko Kawachi, Jun-ichi Takeda, Kinji Ohno

The 42st Annual Meeting of the Molecular Biology Society of Japan  2019.12 

The interaction between SRSF3 and hnRNP K regulates the splicing of internal large exons

Akio Masuda, Toshihiko Kawachi, Yoshihiro Yamachita, Kinji Ohno

The 21st RNA Meeting  2019.7 

Targeted RNA immunoprecipitation (tRIP) identified FUS-U1 snRNP interaction on nascent RNA as a regulator of mRNA length

Akio Masuda, Toshihiko Kawachi, Jun-ichi Takeda, Kinji Ohno

The 41st Annual Meeting of the Molecular Biology Society of Japan  2018.11 

Efficient identification of protein-protein-RNA tertiary interaction in living cells International conference

Binding of FUS to promoter upstream transcripts, PROMPTs, globally regulates gene transcription International conference

Akio Masuda, Jun-ichi Takeda, Takaaki Okamoto, Kinji Ohno

The annual meeting of the RNA society 

Position-specific binding of FUS regulates mRNA length

Position-specific binding of FUS to nascent RNA regulates alternative polyadenylation

Akio Masuda, Junichi Takeda, Tatsuya Okuno, Kinji Ohno

The 37th Annual Meeting of the Molecular Biology Society of Japan  

FUS regulates transcription termination through binding to nascent RNA International conference

Masuda A, Okuno T, Okamoto T, Ohno K

43rd Annual Meeting, Society for Neuroscience  

Global analysis reveals relationship between RNA-binding sites of FUS and transcriptional regulation International conference

Masuda A, Okuno T, Okamoto T, Ohno K

8th Brain Research Conference 

Global mapping of FUS-binding sites and global profiling of FUS-mediated RNA metabolisms in the mouse brain International conference

Masuda A, Ishigaki S, Fujioka Y, Iguchi Y, Katsuno M, Shibata A, Urano F, Sobue G, Ohno K

62nd Annual Meeting of the American Society of Human Genetics 

Global analysis of RNA-binding sites of CUGBP1 and MBNL1 reveal their preferential binding to 3' UTRs to regulate mRNA stability International conference

Masuda A, Andersen HS, Doktor TK, Okamoto T, Ito I, Andresen BS, Ohno K

The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center 

Genome-wide analysis of RNA-binding sites of HuR International conference

Masuda A, Ito M, Fujita Y, Ohno K

16th Annual Meeting of the RNA Society 

マスト細胞に発現するTLRシグナル伝達

松口徹也 増田章男

第15回日本アレルギー学会 春季臨床大会 シンポジウム2 

LPSによる気道アレルギー性炎症増悪における、マスト細胞の役割

2003

（財）花王芸術・科学財団　平成16年度科学技術研究助成 

The role of ceramide in mast cell functions

2003

マスト細胞におけるIL-13産生機構の解析

2002

名古屋大学学術振興基金　Ｈ14年度学術研究助成 

マスト細胞におけるTH2サイトカイン産生機構の解析

2002

（財）日本アレルギー協会　北陸製薬　アレルギー学術奨励賞 

Elucidation of molecular mechanisms of neuromuscular junction formations in physiology and pathology

Grant number：20H03561  2020.4 - 2023.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Ohno Kinji

Analysis of the molecular basis of MERS-delirious behavior spectrum

Grant number：18K07890  2018.4 - 2023.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Okumura Akihisa

Identification of the role of transcription termination and polyadenylation in ALS using multiple high-throughput sequencing analysis

Grant number：18K06058  2018.4 - 2022.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Masuda Akio

Identification of the role of transcription termination and polyadenylation in the pathogenesis of ALS using multiple high-throughput sequencing analyses

Grant number：15K06755  2015.4 - 2019.3

Masuda Akio

アルギニンのメチル化と翻訳による新たな細胞分裂制御機構の解析 研究課題

Grant number：15K14505  2015.4 - 2017.3

増田 章男

RNAスプライシングを介した新たな細胞分裂開始機構の解明

Grant number：15K14505  2013.4 - 2015.3

増田 章男

神経筋接合部の正常構築と分子病態研究（大野欽司）

2012.4 - 2015.3

科学研究費補助金  基盤研究(B)

大野欽司

神経筋接合部特異的スプライシング機構の解明

2012.4 - 2015.3

科学研究費補助金  基盤研究(C)

増田　章男

神経筋接合分子欠損症におけるmRNA病態研究と治療法開発研究（大野欽司）

2009.4 - 2012.3

科学研究費補助金  基盤研究(B)

大野欽司

生活環境における吸入気体組成の調節に基づく健康維持と疾患制御の試み（市原正智）

2008.4 - 2011.3

科学研究費補助金  新学術領域研究 （研究課題提案型） 代表：市原正智 　課題番号：20200021

市原正智

アレルギー病態におけるＲＮＡ結合蛋白ＲＯＤ１の役割

2008.4 - 2011.3

科学研究費補助金  基盤研究(C)

増田　章男

神経筋接合分子欠損症および他の筋疾患におけるmRNA病態研究と治療法開発研究（大野欽司）

2007.4 - 2009.3

科学研究費補助金  基盤研究(B)

大野欽司

先天性筋無力症候群に関与する神経筋接合部分子の分子病態研究（大野欽司）

2005.4 - 2007.3

科学研究費補助金  基盤研究(B)

大野欽司

マスト細胞におけるIL-15レセプターの解析

2002.4 - 2004.3

科学研究費補助金  若手研究(B)

増田章男

生物学基礎I

2018

生物学基礎I

2017

病因病態解析学特論

2017

生物学基礎I

2016

生物学基礎I

2015

生物学基礎I

2014

生物学基礎I

2013

生物学基礎I

2012

生物学基礎I

2011

生物学基礎I

2010

生物学基礎I

2009