Updated on 2022/05/18

写真a

 
YATSUYA Hiroshi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor
Contact information
メールアドレス
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Degree 1

  1. PhD ( 2003.1   Nagoya University ) 

Research Interests 11

  1. prevention

  2. 循環器疾患

  3. 肥満

  4. 生活習慣病

  5. 疫学

  6. 公衆衛生

  7. 糖尿病

  8. cardiovascular diseases

  9. cohort studies

  10. non-communicable diseases

  11. obesity

Research Areas 5

  1. Life Science / Hygiene and public health (non-laboratory)

  2. Life Science / Medical management and medical sociology

  3. Life Science / Hygiene and public health (non-laboratory)

  4. Life Science / Hygiene and public health (laboratory)

  5. Life Science / Hygiene and public health (laboratory)

Current Research Project and SDGs 1

  1. 生活習慣病の疫学研究

Research History 10

  1. 名古屋大学大学院医学系研究科   国際保健医療学・公衆衛生学   教授

    2020.10

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    Country:Japan

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  2. 藤田保健衛生大学医学部(藤田医科大学)   公衆衛生学   教授

    2012.7 - 2021.3

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    Country:Japan

  3. Fujita Health University   School of Medicine   Professor

    2012.7 - 2021.3

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  4. 名古屋大学 大学院医学系研究科   国際保健医療学・公衆衛生学分野   准教授

    2011.4 - 2012.6

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    Country:Japan

  5. 名古屋大学 大学院医学系研究科   公衆衛生学分野   准教授

    2010.9 - 2011.3

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    Country:Japan

  6. Visiting Associate Professor, University of Minnesota Division of Epidemiology and Community Health

    2008.9 - 2010.8

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    Country:United States

  7. Associate Professor, Nagoya University Graduate School of Medicine

    2007.4 - 2010.8

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    Country:Japan

  8. Associate Professor, Nagoya University Graduate School of Medicine

    2004.6 - 2007.3

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    Country:Japan

  9. Assistant Professor, Nagoya University Graduate School of Medicine

    2000.5 - 2004.6

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    Country:Japan

  10. Handa Municipal Hospital

    1996.5 - 1997.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medicine   Program in Social Medicine

    1997.4 - 2000.4

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 1996.3

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    Country: Japan

Professional Memberships 19

  1. Japan Epidemiological Association

  2. Japanese Society of Public Health

  3. Japan Society for Occupational Health

  4. Japanese Association for Cerebro-cardiovascular Disease Control

  5. 日本学校保健学会

  6. 東海公衆衛生学会

  7. 日本社会医学会

  8. Japan Society for the Study of Obesity

  9. 日本動脈硬化学会

  10. The Japanese Circulation Society

  11. International Epidemiological Association

  12. American Heart Association

  13. 日本動脈硬化学会

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  14. JAPANESE SOCIETY OF PUBLIC HEALTH

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  15. THE JAPANESE ASSOCIATION OF SCHOOL HEALTH

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  16. 東海公衆衛生学会

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  17. JAPAN SOCIETY FOR THE STUDY OF OBESITY

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  18. 日本産業衛生学会

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  19. 日本循環器病予防学会

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Committee Memberships 23

  1. 日本学術会議   連携会員  

    2014.10   

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    Committee type:Government

    第23期生活習慣病対策分科会幹事(2014-2017)
    第24期生活習慣病対策分科会委員長(2017-2020)
    第25期生活習慣病対策分科会委員長(2020-2023)

  2. 内閣府食品安全委員会   ビスフェノールAの健康影響に関する調査事業検討会委員  

    2019.8 - 2020.3   

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    Committee type:Government

  3. 岩倉市健幸づくり推進委員会   委員長  

    2019.5   

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    Committee type:Municipal

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  4. 東海公衆衛生学会   理事  

    2018.4   

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    Committee type:Academic society

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  5. 日本学術会議 生活習慣病対策分科会   委員長  

    2018.2   

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    Committee type:Government

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  6. 愛知県医師会   地域医療政策研究機構委員会・委員  

    2018.1   

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    Committee type:Other

  7. 日本疫学会 広報委員会   委員  

    2018.1   

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    Committee type:Academic society

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  8. Journal of Epidemiology   編集委員  

    2017.1   

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    Committee type:Academic society

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  9. Journal of Epidemiology   Associate Editor  

    2017.1   

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    Committee type:Academic society

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  10. Fujita Medical Journal   編集委員長  

    2015.2   

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    Committee type:Academic society

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  11. Fujita Medical Journal   Editor-in-Chief  

    2015.2   

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    Committee type:Academic society

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  12. 日本学術会議   連携会員  

    2014.10   

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    Committee type:Government

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  13. Science Council of Japan   member  

    2014.10   

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    Committee type:Government

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  14. 東海公衆衛生雑誌   編集委員  

    2014.10 - 2017.7   

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    Committee type:Academic society

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  15. 日本公衆衛生学会   評議員  

    2014.7   

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    Committee type:Academic society

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  16. 日本疫学会   評議員  

    2013.1   

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    Committee type:Academic society

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  17. 日本産業衛生学会   代議員  

    2012.11   

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    Committee type:Academic society

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  18. Journal of Atherosclerosis and Thrombosis   編集委員  

    2012.10   

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    Committee type:Academic society

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  19. Journal of Atherosclerosis and Thrombosis   Editor  

    2012.10   

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    Committee type:Academic society

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  20. 東海公衆衛生学会   評議員  

    2012.4 - 2018.3   

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    Committee type:Academic society

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  21. 日本循環器病予防学会(循環器管理研究協議会)   評議員  

    2010.5   

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    Committee type:Academic society

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  22. 農林水産省   「食事バランスガイド」を活用した「日本型食生活」の効果を科学的に検証 する事業、検討会委員  

    2008.4 - 2009.3   

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    Committee type:Government

  23. 国立研究開発法人 国立長寿医療研究センター   倫理・利益相反委員会 委員  

       

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    Committee type:Other

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Awards 4

  1. Young Investigator Award

    2007.1   Japan Epidemiological Association  

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    Country:Japan

  2. Young Investigator Award

    2007.7   Japan Society for Social Medicine  

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    Country:Japan

  3. Journal of Epidemiology ベストレビューアー賞

    2016.1   日本疫学会  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  4. Journal of Epidemiology ベストレビューアー賞

    2012.1   日本疫学会  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

 

Papers 270

  1. Implementation strategies for the patient safety reporting system using Consolidated Framework for Implementation Research: a retrospective mixed-method analysis.

    Koike D, Ito M, Horiguchi A, Yatsuya H, Ota A

    BMC health services research   Vol. 22 ( 1 ) page: 409   2022.3

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    Background: Healthcare-related adverse events occur because of complex healthcare systems. The patient safety reporting system is a core component of patient safety initiatives in hospitals. However, hospital management often encounters a cultural barrier with its implementation and struggles to overcome the same. Implementation science would be useful for analysing implementation strategies. This study determines the effects of the implemented strategy on an increase in the number of patient safety reports and the determinants of successful implementation, using the implementation framework. Methods: Mixed method analysis was performed in Fujita Health University Hospital (FHUH), a large volume hospital in Japan. We identified strategies to implement the patient safety reporting system by scrutinising internal documents using the Consolidated Framework for Implementation Research (CFIR). The electronic reporting systems developed in 2004 in the FHUH and the number of reports were analysed using the staff data and hospital volumes. Results: Reports (n = 110,058) issued between April 2004 and March 2020 were analysed. The number of reports increased from 2004 to 2008 and from 2013 to 2019, reaching 14,037 reports per year. Between 2009 and 2012, the FHUH experienced a stagnation period where the number of reports were not increasing. From the qualitative materials, we identified 74 strategies which contributed to the implementation of the patient safety reporting system. Among these, the domain of ‘intervention characteristics’ in the CFIR contained 12 strategies, ‘outer settings’ contained 20, ‘inner settings’ contained 21, ‘characteristics of individuals’ contained 8, and ‘process’ contained 13. There were two concentrated periods of the implemented strategies, the number was 17 in 2007 and 10 in 2016. These concentrated periods preceded a remarkable increase in the number of patient safety reports. Conclusions: A safety culture had been fostered in FHUH in the study period. A relationship between number of strategies and development of a reporting culture was observed. The intensity of adequate strategies was needed for implementation of patient safety reporting system. Therefore, the implementation framework is useful for analysing patient safety initiatives for safety culture.

    DOI: 10.1186/s12913-022-07822-9

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  2. Applicability of a web-based 24-hour dietary recall tool for Japanese populations in large-scale epidemiological studies

    Hose Yoshie, Ishihara Junko, Kotemori Ayaka, Nakadate Misako, Maruya Sachiko, Tanaka Junta, Yatsuya Hiroshi, Aoyama Atsuko, Chiang Chifa, Konta Tsuneo, Kayama Takamasa, Ueno Yoshiyuki, Inoue Manami, Sawada Norie, Tsugane Shoichiro, Takachi Ribeka

    Journal of Epidemiology   Vol. advpub ( 0 )   2022.3

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    Language:English   Publisher:Japan Epidemiological Association  

    DOI: 10.2188/jea.JE20220071

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  3. Smoking cessation, weight gain and risk of cardiovascular disease. International journal

    Xiaowen Wang, Jia-Yi Dong, Renzhe Cui, Isao Muraki, Kokoro Shirai, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

    Heart (British Cardiac Society)   Vol. 108 ( 5 ) page: 375 - 381   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: To examine whether the relationship between smoking cessation and risk of cardiovascular disease (CVD) was modified by weight gain. METHODS: A total of 69 910 participants (29 650 men and 46 260 women) aged 45-74 years were grouped into six groups by smoking status in the first and 5-year surveys: sustained smokers, recent quitters according to postcessation weight gain (no weight gain, 0.1-5.0 kg, >5.0 kg), long-term quitters and never smokers. Quitting smoking within and longer than 5 years were defined as recent and long-term quitters, respectively. We used Cox proportional hazard models to estimate the HR for incident CVD, coronary heart disease (CHD) and stroke. RESULTS: We identified 4023 CVDs (889 CHDs and 3217 strokes) during a median of 14.8 years of follow-up. Compared with sustained smokers, the multivariable HR (95% CI) for CVD was 0.66 (0.52 to 0.83) for recent quitters without weight gain, 0.71 (0.55 to 0.90) for recent quitters with weight gain of 0.1-5.0 kg, 0.70 (0.44 to 1.10) for recent quitters with weight gain of >5.0 kg, 0.56 (0.49 to 0.64) for long-term quitters, and 0.60 (0.55 to 0.66) for never smokers. The analysis restricted to men showed a similar association. Prespecified analysis by age suggested that recent quitters overall had a lower HR for CVD among those aged <60 years vs ≥60 years. Similar patterns of association were observed in CHD and stroke. CONCLUSIONS: Postcessation weight gain did not attenuate the protective association between smoking cessation and risk of CVD.

    DOI: 10.1136/heartjnl-2021-318972

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  4. Work and Family Conflicts, Depression, and “Ikigai”: A Mediation Analysis in a Cross-Cultural Study Between Japanese and Egyptian Civil Workers

    Eshak Ehab S., Baba Sachiko, Yatsuya Hiroshi, Iso Hiroyasu, Hirakawa Yoshihisa, Mahfouz Eman M., Chifa Chiang, Sakaniwa Ryoto, El-khateeb Ayman S.

    Journal of Epidemiology   Vol. advpub ( 0 )   2022.2

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    <p><b>Background:</b> Work-family conflicts (total-WFCs) could associate with mental health, and having ikigai (a purpose of life) may mediate this association.</p><p><b>Methods:</b> In a cross-cultural study of 4792 Japanese Aichi Workers’ Cohort study participants and 3109 Egyptian civil workers, the Midlife Development in the United States (MIDUS) questionnaire measured total-WFCs and Center for Epidemiological Studies Depression (CES-D) 11-item scale measured depression. Logistic regression models estimated odds ratios (ORs) of having depression and a high-ikigai across levels of total-WFCs (low, moderate, and high), and the PROCESS macro of Hayes tested the mediation effect.</p><p><b>Results:</b> The prevalence of high total-WFCs, depression, and having a high-ikigai were 17.9%, 39.4%, and 70.1% in Japanese women, 10.5%, 26.8%, and 70.1% in Japanese men, 23.7%, 58.2%, and 24.7% in Egyptian women, and 19.1%, 38.9%, and 36.9% in Egyptian men. Compared with participants with low total-WFCs, the multivariable ORs (95% CIs) of depression in Japanese women and men with high total-WFCs were 4.11 (2.99-5.65) and 5.42 (4.18-7.02), and those in Egyptian women and men were 4.43 (3.30-5.95) and 4.79 (3.53-6.48). The respective ORs of having a high-ikigai were 0.46 (0.33-0.64) and 0.40 (0.31-0.52) in Japanese women and men and were 0.34 (0.24-0.48) and 0.28 (0.20-0.39) in Egyptian women and men. No interaction between total-WFCs and country was observed for the associations with depression or ikigai. Ikigai has mediated (up to 18%) the associations between the total-WFCs and depression, especially in Egyptian civil workers.</p><p><b>Conclusions:</b> Total-WFCs were associated with depression, and having low-ikigai mediated these associations in Japanese and Egyptian civil workers.</p>

    DOI: 10.2188/jea.JE20210338

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  5. Everyday wishes of older people living with dementia in care planning: a qualitative study.

    Mamun MR, Hirakawa Y, Saif-Ur-Rahman KM, Sakaguchi T, Chiang C, Yatsuya H

    BMC health services research   Vol. 22 ( 1 ) page: 184   2022.2

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    Background: The dementia care policy in Japan emphasizes the views of people living with dementia in care planning. An exploration of the everyday wishes of older people living with dementia can help clarify their priorities and assist in improving dementia care. This study aimed to explore the everyday wishes of older people living with dementia in Japan. Methods: This qualitative study was conducted in Aichi prefecture in Japan. Older people with mild to moderate dementia were considered for inclusion. Participants were recruited from a dementia outpatient clinic. In-depth interviews were conducted with 36 participants in the same dementia outpatient clinic from January to October 2019. Audio-recorded interviews were transcribed verbatim. Inductive content analysis was carried out to analyze the data. Findings: Participants expressed their everyday wishes within five themes (desire of being connected, freedom to decide, involvement in activities, status quo, and self-reliance). Older people living with dementia loved the connection with their family and wanted to have an enjoyable life by engaging in several activities without others’ interference. They desired to maintain the status quo and not be a burden to others. Conclusions: This study provides evidence on the everyday wishes of people living with dementia. Identified wishes are mostly on emotional aspects of their daily lives. The findings of our study might help provide care for the people living with dementia considering their wishes. Further exploration, including people with severe dementia, is needed.

    DOI: 10.1186/s12913-022-07606-1

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  6. Age and sex differences in factors associated with hypertension among an urban poor population in Bangladesh.

    Al-Shoaibi AAA, Chiang C, Khalequzzaman M, Choudhury SR, Hirakawa Y, Islam SS, Aoyama A, Yatsuya H

    Nagoya journal of medical science   Vol. 84 ( 1 ) page: 69 - 79   2022.2

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    This study explores the differences in factors associated with hypertension between younger and older subjects in an urban slum community in Bangladesh. We analyzed the data of 1,008 men and 1,001 women obtained from a cross-sectional survey conducted between October 2015 and April 2016. Multivariable logistic regression models were stratified by age (18 to 44 and 45 to 64 years) in men and women separately. The multivariable model included age (continuous) and the following categorical variables simultaneously: education duration, marital status, tobacco smoking, smokeless tobacco use, total physical activity, body mass index (BMI), waist circumference, and the blood levels of glycated hemoglobin (HbA1c), triglycerides, high and low-density lipoprotein (HDL and LDL) cholesterol. Hypertension was defined as the presence of either blood pressure ≥140/90 mmHg or the use of antihypertensive medication. The prevalence of hypertension was 13.0% (younger men), 14.6% (younger women), 35.6% (older men), and 38.7% (older women). In younger men, higher waist circumference and increased LDL cholesterol levels were significantly associated with hypertension. In older men, physical activity was the only significant factor that was inversely associated with hypertension. In younger women, higher BMI, increased HbA1c, triglycerides, and LDL cholesterol levels were associated with hypertension. In older women, a higher HbA1c was the only factor significantly associated with hypertension. These findings suggest that public health interventions to prevent hypertension may require different approaches according to sex and age groups within the poor urban population in Bangladesh.

    DOI: 10.18999/nagjms.84.1.69

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  7. Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament.

    Nakashima H, Imagama S, Yoshii T, Egawa S, Sakai K, Kusano K, Nakagawa Y, Hirai T, Wada K, Katsumi K, Fujii K, Kimura A, Furuya T, Kanchiku T, Nagamoto Y, Oshima Y, Nagoshi N, Ando K, Takahata M, Mori K, Nakajima H, Murata K, Matsunaga S, Kaito T, Yamada K, Kobayashi S, Kato S, Ohba T, Inami S, Fujibayashi S, Katoh H, Kanno H, Li Y, Yatsuya H, Koda M, Kawaguchi Y, Takeshita K, Matsumoto M, Yamazaki M, Okawa A, Japanese Multicenter Research Organization for Ossification of the Spinal Ligament.

    Scientific reports   Vol. 12 ( 1 ) page: 748   2022.1

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    This prospective multicenter study, established by the Japanese Ministry of Health, Labour and Welfare and involving 27 institutions, aimed to compare postoperative outcomes between laminoplasty (LM) and posterior fusion (PF) for cervical ossification of the posterior longitudinal ligament (OPLL), in order to address the controversy surrounding the role of instrumented fusion in cases of posterior surgical decompression for OPLL. 478 patients were considered for participation in the study; from among them, 189 (137 and 52 patients with LM and PF, respectively) were included and evaluated using the Japanese Orthopaedic Association (JOA) scores, the JOA Cervical Myelopathy Evaluation Questionnaire (JOACMEQ), and radiographical measurements. Basic demographic and radiographical data were reviewed, and the propensity to choose a surgical procedure was calculated. Preoperatively, there were no significant differences among the participants in terms of patient backgrounds, radiographical measurements (K-line or cervical alignment on X-ray, OPLL occupation ratio on computed tomography, increased signal intensity change on magnetic resonance imaging), or clinical status (JOA score and JOACMEQ) after adjustments. The overall risk of perioperative complications was found to be lower with LM (odds ratio [OR] 0.40, p = 0.006), and the rate of C5 palsy occurrence was significantly lower with LM (OR 0.11, p = 0.0002) than with PF. The range of motion (20.91° ± 1.05° and 9.38° ± 1.24°, p < 0.0001) in patients who had PF was significantly smaller than in those who had LM. However, multivariable logistic regression analysis showed no significant difference among the participants in JOA score, JOA recovery rate, or JOACMEQ improvement at two years. In contrast, OPLL progression was greater in the LM group than in the PF group (OR 2.73, p = 0.0002). Both LM and PF for cervical myelopathy due to OPLL had resulted in comparable postoperative outcomes at 2 years after surgery.

    DOI: 10.1038/s41598-021-04727-1

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  8. Stoma creation is associated with a low incidence of midline incisional hernia after colorectal surgery: the "fighting over the fascia" theory concerning the incision and stoma hole.

    Ohara N, Uehara K, Ogura A, Sando M, Aiba T, Murata Y, Mizuno T, Toshio K, Yokoyama Y, Ishigaki S, Li Y, Yatsuya H, Ebata T

    Surgery today     2022.1

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    Purpose: Parastomal hernia (PH) develops more frequently than incisional hernia (IH) after colorectal surgery with stoma. This study evaluated our hypothesis that inward traction of the fascia when closing a midline incision widens the stoma hole and increases the incidence of PH. Methods: A total of 795 patients who underwent colorectal resection between 2006 and 2016 were retrospectively analyzed. The risk classification was constructed from IH risk factors extracted from the non-stoma group. Then, the classification was extrapolated to the stoma group for predicting midline IH and PH. Results: The incidence of IH was 5.3% in the stoma group and 12.5% in the non-stoma group (p = 0.005). PH developed in 19.6% of 97 patients with permanent stoma. The risk classification was able to predict PH without a significant difference but was well balanced in patients with permanent stoma; however, it failed to predict IH in the stoma group. Conclusion: The risk classification constructed from the non-stoma group was useful for predicting not midline IH but PH, suggesting that the stoma site was the most vulnerable for herniation. The “fighting over the fascia” theory between the midline incision and stoma hole may explain the causal relationship between the midline IH and PH.

    DOI: 10.1007/s00595-021-02434-y

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  9. Association between long-term alcohol consumption and insomnia symptoms in civil servants: Aichi Workers’ Cohort Study

    Terabe Motoi, Kitajima Tsuyoshi, Ota Atsuhiko, Yatsuya Hiroshi, Iwata Nakao

    Fujita Medical Journal   Vol. advpub ( 0 )   2022

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    <p><b>Objectives:</b> The influence of habitual alcohol consumption on insomnia symptoms in healthy workers remains unclear. In this study, we evaluated the association between habitual alcohol consumption among civil servants and insomnia symptoms such as difficulty falling asleep, difficulty staying asleep, and tiredness after sleep, using longitudinal data.</p><p><b>Methods:</b> We enrolled civil servants in a prospective cohort study who completed questionnaires at baseline. Of those, 2861 participants were revaluated in a 5-year follow-up survey. Insomnia symptoms during the past month were assessed using self-reporting. Alcohol drinking habits were assessed by querying the frequency of drinking alcohol as well as the amount of alcohol usually consumed per one occasion.</p><p><b>Results:</b> Drinking alcohol every day was less likely to have difficulty falling asleep (odds ratio, 0.42 95% confidence interval, 0.20–0.89), and drinking alcohol 3 or more days a week was associated with difficulty staying asleep (odds ratio, 1.48; 95% confidence interval, 1.16–1.90).</p><p><b>Conclusions:</b> Drinking alcohol every day may produce subjective improvement in sleep onset. However, drinking alcohol 3 or more days a week may increase arousal during sleep, which contributes to reduced sleep quality. These results suggest the possibility that long-term daily habitual drinking may reinforce a sense of improvement in subjective sleep onset but may possibly induce sleep disturbance.</p>

    DOI: 10.20407/fmj.2021-015

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  10. Association between C-reactive protein and risk of overall and 18 site-specific cancers in a Japanese case-cohort

    Suzuki S., Katagiri R., Yamaji T., Sawada N., Imatoh T., Ihira H., Inoue M., Tsugane S., Iwasaki M., Sawada N., Tsugane S., Iwasaki M., Inoue M., Yamaji T., Katagiri R., Miyamoto Y., Abe S.K., Tanaka S., Moriya T., Minamizono T., Shirai Y., Kuniyoshi H., Yoshimi T., Sonoda H., Tagami T., Ando T., Kimura T., Kokubo Y., Yamagishi K., Mizoue T., Nakamura K., Takachi R., Ishihara J., Iso H., Kitamura T., Saito I., Yasuda N., Mimura M., Sakata K., Noda M., Goto A., Yatsuya H.

    British Journal of Cancer     2022

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    Language:Japanese   Publisher:British Journal of Cancer  

    Background: Evidence of the association between chronic low-grade inflammation, as reflected by C-reactive protein (CRP) measurements, and cancer risk is equivocal. Specifically, few studies have examined this in uncommon cancers and Asian populations. Methods: We utilised a case-cohort design consisting of multi-types of cancer (N = 3608), and a random subcohort (N = 4432) in a Japanese large population-based study, with a median follow-up time of 15.6 years, and measured baseline plasma CRP using high sensitivity assay. The hazard ratios (HRs) were estimated using weighted Cox proportional hazards methods. Results: The multivariable-adjusted HR (95% confidence interval) for the top quartile of CRP was 1.28 (1.11‒1.48) (Ptrend < 0.001) for overall cancer compared to the bottom quartile of CRP. Among site-specific cancers, higher CRP levels were associated with an increased risk of colorectal, lung, breast, biliary tract, and kidney cancer, and leukaemia. These positive associations remained among participants after >3 years’ follow-up. Furthermore, subgroup analyses for overall cancer robustly showed a positive association with CRP levels, regardless of sex and obesity. Conclusion: Our consistent findings suggested that chronic low-grade inflammation measured by CRP is associated with the risk of cancer.

    DOI: 10.1038/s41416-022-01715-8

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  11. Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study

    Matsunaga Masaaki, Yatsuya Hiroshi, Iso Hiroyasu, Li Yuanying, Yamagishi Kazumasa, Tanabe Naohito, Wada Yasuhiko, Ota Atsuhiko, Tamakoshi Koji, Tamakoshi Akiko, The JACC Study Group

    Journal of Atherosclerosis and Thrombosis   Vol. advpub ( 0 )   2021.12

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    <p><b>Aim: </b>We aimed to examine the association of obesity-related cancer and cardiovascular disease (CVD) with body mass index (BMI) and the estimated population attributable fraction in lean Asians.<b> </b></p><p><b>Methods: </b>We studied 102,535 participants aged 40-79 years without histories of cancer or CVD at baseline between 1988 and 2009. The cause-specific hazard ratios (csHRs) of BMI categories (<18.5, 18.5-20.9, 21.0-22.9 [reference], 23.0-24.9, 25.0-27.4, and ≥ 27.5 kg/m<sup>2</sup>) were estimated for each endpoint. The events considered were mortalities from obesity-related cancer (esophageal, colorectal, liver, pancreatic, kidney, female breast, and endometrial cancer) and those from CVD (coronary heart disease and stroke). Population attributable fractions (PAFs) were calculated for these endpoints.<b> </b></p><p><b>Results: </b>During a 19.2-year median follow-up, 2906 died from obesity-related cancer and 4532 died from CVD. The multivariable-adjusted csHRs (95% confidence interval) of higher BMI categories (25-27.4 and ≥ 27.5 kg/m<sup>2</sup>) for obesity-related cancer mortality were 0.93 (0.78, 1.10) and 1.18 (0.92, 1.50) in men and 1.25 (1.04, 1.50) and 1.48 (1.19, 1.84) in women, respectively. The corresponding csHRs for CVD mortality were 1.27 (1.10, 1.46) and 1.59 (1.30, 1.95) in men and 1.10 (0.95, 1.28) and 1.44 (1.21, 1.72) in women, respectively. The PAF of a BMI ≥ 25 kg/m<sup>2</sup> for obesity-related cancer was −0.2% in men and 6.7% in women and that for CVD was 5.0% in men and 4.5% in women.<b> </b></p><p><b>Conclusion: </b>A BMI ≥ 25 kg/m<sup>2</sup> is associated with an increased risk of obesity-related cancer in women and CVD in both sexes.</p>

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  12. The association of work-related stress according to the demand-control model with aggravation of pre-existing disease during the first state of COVID-19 emergency in Japan.

    Yupeng He, Hiroshi Yatsuya, Chifa Chiang, Atsuhiko Ota, Ryo Okubo, Tomohiro Ishimaru, Takahiro Tabuchi

    Journal of epidemiology   Vol. 31 ( 12 ) page: 642 - 647   2021.12

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    BACKGROUND: The job environment has changed a lot during the period of coronavirus disease 2019 (COVID-19) pandemic. This study aimed to investigate the association between work-related stress and aggravation of pre-existing disease in workers during the first state of COVID-19 emergency in Japan. METHODS: Data were obtained from a large internet survey conducted between August 25 and September 30, 2020 in Japan. Participants who reported that they had a job as well as current history of disease(s) (i.e., pre-existing conditions) were included (n=3090). Aggravation of pre-existing disease during the state of emergency was self-reported. Work-related stress from April 2020 (since the state of COVID-19 emergency) was assessed according to job demand-control model. Multivariable logistic regression models were used to analyze the association. RESULTS: Aggravation of pre-existing diseases was reported by 334 participants (11%). The numbers of participants with high demand and low control were 112 (18%) and 100 (14%), respectively. Compared to medium demand, high demand was significantly associated with aggravation of pre-existing diseases (odds ratio: 1.77, 95% confidence interval: 1.30-2.42). Low control compared to medium control was significantly associated with aggravation of pre-existing diseases (odds ratio: 1.39, 95% confidence interval: 1.02-1.92). CONCLUSION: Work-related stress during the first state of COVID-19 emergency was associated with aggravation of pre-existing disease during that period.

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  13. Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study. Reviewed International journal

    Atsuhiko Ota, Yuanying Li, Hiroshi Yatsuya, Kozo Tanno, Kiyomi Sakata, Kazumasa Yamagishi, Hiroyasu Iso, Nobufumi Yasuda, Isao Saito, Tadahiro Kato, Kazuhiko Arima, Yoko Sou, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Manami Inoue, Motoki Iwasaki, Norie Sawada, Shoichiro Tsugane

    Journal of cancer survivorship : research and practice   Vol. 15 ( 6 ) page: 912 - 921   2021.12

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    PURPOSE: This study compared working cancer survivors' self-rated health status (SRHS), physical functional capacity, depressive symptoms, and happiness to those of cancer-free workers. METHODS: A nationwide general population-based cross-sectional study on a sample of Japanese was conducted. Prevalence of deteriorated SRHS, restricted physical functional capacity, depressive symptoms, and perceived happiness were compared between working cancer survivors and cancer-free workers with multivariable logistic regression analysis adjusted for age and sociodemographic and health-related backgrounds. RESULTS: Of the 28,311 male and 26,068 female workers, 977 (3.5%) and 1267 (4.9%) were cancer survivors, respectively. Working cancer survivors reported deteriorated SRHS more frequently than cancer-free workers: 21.3% vs. 13.8%, multivariable-adjusted odds ratio (95% confidence interval), 1.64 (1.39-1.95) for men, 23.8% vs. 17.5%, 1.34 (1.16-1.54) for women. Restricted physical functional capacity was reported more frequently in working cancer survivors than cancer-free workers: 6.8% vs. 2.6%, 1.76 (1.34-2.32) for men, 4.9% vs. 2.0%, 2.06 (1.56-2.71) for women. No significant difference was found for depressive symptoms: 21.6% vs. 22.9% in men, 30.0% vs. 28.5% in women. Working cancer survivors felt happiness more frequently than cancer-free survivors in men (77.3% vs. 71.7%, 1.21 (1.01-1.45)) but not in women (76.1% vs. 74.9%). CONCLUSIONS: Working cancer survivors had worse SRHS and more restricted physical functional capacity than cancer-free workers. In men, working cancer survivors felt happiness more frequently than cancer-free workers. IMPLICATIONS FOR CANCER SURVIVORS: Continuous support to improve cancer survivors' SRHS and physical functional capacity would be necessary even while they are working.

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  14. Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration

    Hiroki Kaneko, Noriko Takashi, Masaaki Matsunaga, Yasuki Ito, Jun Takeuchi, Hiroko Terasaki, Hiroshi Yatsuya, Koji M. Nishiguchi

    Graefe's Archive for Clinical and Experimental Ophthalmology   Vol. 259 ( 12 ) page: 3589 - 3596   2021.12

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    Purpose: To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged. Method: The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012–2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded. Results: The monthly numbers of cases of SMHs caused by AMD from January to December were 6, 8, 4, 9, 7, 10, 9, 11, 7, 11, 3, and 10. No significant seasonal variation in the monthly incidence was identified (Roger’s R = 1.89, p = 0.39). The monthly numbers of SMHs caused by RMAs from January to December were 3, 11, 11, 8, 7, 8, 5, 5, 2, 4, 7, and 5. There was significant seasonal variation in the monthly incidence (Roger’s R = 7.67, p = 0.02). There was no significant correlation between the monthly incidence of SMHs caused by RMAs and mean ambient temperature. Conclusion: Our previous study conducted for cases obtained in 1998–2005 showed seasonal cyclic trend in the number of SMHs caused by AMD, with the peak in winter. However, that significant seasonal variation disappeared in 2012–2019 in the present study. Common usage of OCT devices and anti-VEGF drugs might be the reason for the lack of seasonal variation in the cases of SMH caused by AMD. [Figure not available: see fulltext.]

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  15. Peanut Consumption and Risk of Stroke and Ischemic Heart Disease in Japanese Men and Women: The JPHC Study. International journal

    Satoyo Ikehara, Hiroyasu Iso, Yoshihiro Kokubo, Kazumasa Yamagishi, Isao Saito, Hiroshi Yatsuya, Takashi Kimura, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane

    Stroke   Vol. 52 ( 11 ) page: 3543 - 3550   2021.11

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    BACKGROUND AND PURPOSE: Several prospective cohort studies and a randomized clinical trial have shown the beneficial effects of peanut consumption on cardiovascular disease and its risk factors. We examined the association between peanut consumption and risk of cardiovascular disease in Japanese men and women. METHODS: We analyzed data of 74 793 participants aged 45 to 74 years who completed a lifestyle questionnaire including the validated food frequency questionnaire in the Japan Public Health Center-based Prospective Study. They were followed up from 1995 to 2009 for cohort I and from 1998 to 1999 to 2012 for cohort II. Peanut consumption was calculated from the food frequency questionnaire, and the end points were incidence of stroke, ischemic heart disease, and cardiovascular disease (stroke and ischemic heart disease). RESULTS: During a median follow-up of 14.8 years, 3,599 strokes and 849 ischemic heart diseases were reported. Higher peanut consumption was associated with reduced risks of total stroke, ischemic stroke, and cardiovascular disease among men and women. The multivariable hazard ratios (95% CIs) for the highest versus lowest quartiles of peanut consumption after adjustment for age, sex, public health center, smoking, alcohol consumption, perceived stress level, physical activity, vegetable, fruit, fish, soy, sodium and total energy intakes, body mass index, history of hypertension, history of diabetes, and cholesterol-lowering drug were 0.84 (0.77-0.93, P for trend=0.002) for total stroke, 0.80 (0.71-0.90, P for trend=0.002) for ischemic stroke, 0.93 (0.79-1.08, P for trend=0.27) for hemorrhagic stroke, 0.97 (0.80-1.17, P for trend=0.81) for ischemic heart disease and 0.87 (0.80-0.94, P for trend=0.004) for cardiovascular disease, and these associations were similarly observed in both sexes. CONCLUSIONS: Higher peanut consumption was associated with reduced risk of stroke, especially ischemic stroke, but not ischemic heart disease in Japanese men and women.

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  16. Having hobbies and the risk of cardiovascular disease incidence: A Japan public health center-based study. International journal

    Xiaowen Wang, Jia-Yi Dong, Kokoro Shirai, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada

    Atherosclerosis   Vol. 335   page: 1 - 7   2021.10

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    BACKGROUND AND AIMS: The role of hobbies as a protective factor against cardiovascular diseases (CVD) has gained increasing attention; however, no large-scale studies were performed to confirm this. We aimed to examine the association between having hobbies and the risk of total CVD, coronary heart disease (CHD), and stroke in a large Japanese cohort. METHODS: A total of 56,381 adults aged 45-74 years were divided into the non-hobby, having a hobby, and having many hobbies groups. We performed Cox proportional hazard models to estimate the hazard ratio (HRs) for incident CVD, CHD, and stroke after adjusting for potential confounding factors. RESULTS: We identified 3685 incident CVDs (940 CHDs and 2839 strokes) during a median follow-up of 16.3 years. After multivariable adjustment, compared to the non-hobby group, participants having a hobby and many hobbies had a 10% (HR = 0.90 [0.83, 0.97]) and 20% (HR = 0.80 [0.69, 0.93]) lower risk of CVD incidence, respectively. The risk of CHD was lower in those with many hobbies, but the association between having many hobbies and CHD risk was not statistically significant. We also found a similar inverse association for stroke. Compared to the non-hobby group, participants having a hobby and many hobbies had a 13% (HR = 0.87 [0.80, 0.96]) and 20% (HR = 0.80 [0.68, 0.94]) lower risk of stroke. CONCLUSIONS: Having hobbies was associated with a lower risk of CVD. Engagement in hobbies may emerge as an important target for healthy lifestyle promotion for the primary prevention of CVD.

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  17. Association of anthropometric indices of obesity with hypertension among public employees in northern Ethiopia: findings from a cross-sectional survey.

    Saif-Ur-Rahman KM, Chiang C, Weldegerima Gebremariam L, Haregot Hilawe E, Hirakawa Y, Aoyama A, Yatsuya H

    BMJ open   Vol. 11 ( 9 ) page: e050969   2021.9

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    Objectives: The burden of hypertension is increasing in low-income countries, including Ethiopia. Obesity is widely known to be associated with hypertension, but different anthropometric indices of obesity might differ in association with hypertension, which is largely unknown in northern Ethiopia. Design: Data from our previous cross-sectional epidemiological survey were statistically analysed. Setting: Public employees in the regional capital city in northern Ethiopia. Participants: The data of 1380 participants (823 men and 557 non-pregnant women) aged 25 and 64 years were analysed. Outcome measures: The presence of hypertension was the outcome measure and multivariable-adjusted logistic regression analyses were used to investigate the association of body mass index (BMI), waist circumference, and waist-hip ratio in men and women separately. The area under the curve (AUC) for three anthropometric indices for discriminating hypertension was also obtained. Separate analyses were conducted for waist circumference and waist-hip ratio analyses further adjusted for BMI. Results: BMI was linearly associated with hypertension in men (OR for 1 SD increase in BMI 1.45, p=0.001) and women (OR for 1 SD increase in BMI 1.41, p=0.01). The association of waist circumference was independent of BMI both in men (OR for 1 SD increase in waist circumference: 1.74, p=0.002) and women (OR for 1 SD increase in waist circumference: 1.57, p=0.029). The association of waist-hip ratio with hypertension adjusted for BMI was significant in men (OR for 1 SD increase in the waist-hip ratio: 1.46, p<0.001), but was weak and non-significant in women. The AUC for BMI was 0.64 in men and 0.67 in women, while AUC for waist circumference was 0.69 both in men and women. Conclusions: Waist circumference was associated with hypertension independent of BMI among public employees in northern Ethiopia.

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  18. Associations of insomnia with noise annoyance and neighborhood environments: A nationwide cross-sectional study in Japan. International journal

    Tomoya Hanibuchi, Tomoki Nakaya, Tsuyoshi Kitajima, Hiroshi Yatsuya

    Preventive medicine reports   Vol. 23   page: 101416 - 101416   2021.9

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    Despite the increasing knowledge on the association between neighborhood and health, few studies have investigated sleep disorders in Japan, particularly the impact of neighborhood noise on sleep. Thus, this study aimed to investigate the associations between insomnia symptoms and annoyance because of traffic and neighborhood noise in Japan, which has different neighborhood conditions compared with those of the western societies. Neighborhood built and socioeconomic environments roles were also examined. We used nationwide cross-sectional data collected through a 2015 online survey of Japanese adults aged 20-64 years (n = 4,243). Adjusted prevalence ratios for insomnia according to the exposures were estimated using the multilevel Poisson regression models. The results showed that having insomnia was significantly associated with experiencing neighborhood and traffic-noise annoyance. Neighborhood noise had a stronger and independent association with insomnia. However, the neighborhood environmental variables, including population density, deprivation index, and access to commercial areas, were not associated with insomnia. In conclusion, noise annoyance, particularly that sourced from neighbors, is an important factor in relation to sleep health. Health and urban-planning policymakers should consider neighborhood noise, in addition to traffic noise, as health-related issues in residential neighborhoods.

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  19. Estimation of 10-Year Risk of Death from Coronary Heart Disease, Stroke, and Cardiovascular Disease in a Pooled Analysis of Japanese Cohorts: EPOCH-JAPAN. Reviewed

    Yuanying Li, Hiroshi Yatsuya, Sachiko Tanaka, Hiroyasu Iso, Akira Okayama, Ichiro Tsuji, Kiyomi Sakata, Yoshihiro Miyamoto, Hirotsugu Ueshima, Katsuyuki Miura, Yoshitaka Murakami, Tomonori Okamura

    Journal of atherosclerosis and thrombosis   Vol. 28 ( 8 ) page: 816 - 825   2021.8

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    AIMS: We aimed to develop and validate risk prediction models to estimate the absolute 10-year risk of death from coronary heart disease (CHD), stroke, and cardiovascular disease (CVD). METHODS: We evaluated a total of 44,869 individuals aged 40-79 years from eight Japanese prospective cohorts to derive coefficients of risk equations using cohort-stratified Cox proportional hazard regression models. Discrimination (C-index) of the equation was examined in each cohort and summarised using random-effect meta-analyses. Calibration of the equation was assessed using Hosmer-Lemeshow chi-squared statistic. RESULTS: Within a median follow-up of 12.7 years, we observed 765 deaths due to CVD (276 CHDs and 489 strokes). After backward selection, age, sex, current smoking, systolic blood pressure (SBP), proteinuria, prevalent diabetes mellitus, the ratio of total cholesterol to high-density lipoprotein cholesterol (TC/HDLC), interaction terms of age by SBP, and age by current smoking were retained as predictors for CHD. Sex was excluded in the stroke equation. We did not consider TC/HDLC as a risk factor for the stroke and CVD equations. The pooled C-indices for CHD, stroke, and CVD were 0.83, 0.80, and 0.81, respectively, and the corresponding p-values of the Hosmer-Lemeshow tests were 0.18, 0.003, and 0.25, respectively. CONCLUSIONS: Risk equations in the present study can adequately estimate the absolute 10-year risk of death from CHD, stroke, and CVD. Future work will evaluate the system as an education and risk communication tool for primary prevention of CHD and stroke.

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  20. The Association Between Adult Height and Stroke Incidence in Japanese Men and Women: A Population-based Case-Control Study

    Kondo Yoshinobu, Yatsuya Hiroshi, Ota Atsuhiko, Matsumoto Shoji, Ueda Akihiro, Watanabe Hirohisa, Toyoshima Hideaki

    Journal of Epidemiology   Vol. advpub ( 0 )   2021.6

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    <p>Background: No studies have examined the associations between adult height and ischemic stroke subtypes.</p><p>Methods: We conducted a population-based case-control study that included 2,451 thrombotic and 687 embolic stroke cases, as well as 1,623 intracerebral and 768 subarachnoid hemorrhage cases without history of stroke aged 40-79 years, and the same number of sex- and age-matched controls. Cases and controls were grouped according to the quintile cut-off values of height in controls, and the third quintile, which was approximately the average height group, was used as the reference group. Height was also examined as a continuous variable as divided by one standard deviation of height in controls. The analyses were carried out separately for participants aged 40-59 years and 60-79 years.</p><p>Results: In both younger and older men, continuous height was linearly inversely associated with total and thrombotic strokes, and the shortest quintile compared to the reference was associated with increased risks of these strokes. Although height was linearly inversely associated with embolic stroke and intracerebral hemorrhage in younger men, the shortest quintile did not show increased risks of these strokes. Height did not seem to be associated with total stroke and any stroke subtypes in younger women. In contrast, the tallest quintile was significantly associated with increased risks of total stroke and intracerebral hemorrhage, and height tended to be positively associated with these strokes in older women.</p><p>Conclusions: We reported the associations between adult height and ischemic stroke subtypes for the first time, which differed according to sex and age-group.</p>

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  21. Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019

    Reitsma M.B., Kendrick P.J., Ababneh E., Abbafati C., Abbasi-Kangevari M., Abdoli A., Abedi A., Abhilash E.S., Abila D.B., Aboyans V., Abu-Rmeileh N.M., Adebayo O.M., Advani S.M., Aghaali M., Ahinkorah B.O., Ahmad S., Ahmadi K., Ahmed H., Aji B., Akunna C.J., Al-Aly Z., Alanzi T.M., Alhabib K.F., Ali L., Alif S.M., Alipour V., Aljunid S.M., Alla F., Allebeck P., Alvis-Guzman N., Amin T.T., Amini S., Amu H., Amul G.G.H., Ancuceanu R., Anderson J.A., Ansari-Moghaddam A., Antonio C.A.T., Antony B., Anvari D., Arabloo J., Arian N.D., Arora M., Asaad M., Ausloos M., Awan A.T., Ayano G., Aynalem G.L., Azari S., B D.B., Badiye A.D., Baig A.A., Bakhshaei M.H., Banach M., Banik P.C., Barker-Collo S.L., Bärnighausen T.W., Barqawi H.J., Basu S., Bayati M., Bazargan-Hejazi S., Behzadifar M., Bekuma T.T., Bennett D.A., Bensenor I.M., Berfield K.S.S., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bibi S., Bijani A., Bintoro B.S., Biondi A., Birara S., Braithwaite D., Brenner H., Brunoni A.R., Burkart K., Butt Z.A., Caetano dos Santos F.L., Cámera L.A., Car J., Cárdenas R., Carreras G., Carrero J.J., Castaldelli-Maia J.M., Cattaruzza M.S.S., Chang J.C., Chen S., Chu D.T., Chung S.C., Cirillo M., Costa V.M., Couto R.A.S., Dadras O., Dai X., Damasceno A.A.M., Damiani G., Dandona L.

    The Lancet   Vol. 397 ( 10292 ) page: 2337 - 2360   2021.6

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    Background: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings: Globally in 2019, 1·14 billion (95% uncertainty interval 1·13–1·16) individuals were current smokers, who consumed 7·41 trillion (7·11–7·74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. Globally in 2019, smoking tobacco use accounted for 7·69 million (7·16–8·20) deaths and 200 million (185–214) disability-adjusted life-years, and was the leading risk factor for death among males (20·2% [19·3–21·1] of male deaths). 6·68 million [86·9%] of 7·69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation: In the absence of intervention, the annual toll of 7·69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a clear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Funding: Bloomberg Philanthropies and the Bill & Melinda Gates Foundation.

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  22. What constitutes healthiness of Washoku or Japanese diet? Invited Reviewed

    Yatsuya H, Tsugane S

    European journal of clinical nutrition   Vol. 75 ( 6 ) page: 863 - 864   2021.6

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  23. Predictive risk factors for pneumothorax after transbronchial biopsy using endobronchial ultrasonography with a guide sheath. International journal

    Yusuke Gotoh, Teppei Yamaguchi, Hiroshi Yatsuya, Aki Ikeda, Takuya Okamura, Yosuke Sakakibara, Takuma Ina, Yuri Maeda, Mariko Hirochi, Hisashi Kako, Yasuhiro Goto, Sumito Isogai, Naoki Yamamoto, Masashi Kondo, Kazuyoshi Imaizumi

    BMC pulmonary medicine   Vol. 21 ( 1 ) page: 181 - 181   2021.5

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    BACKGROUND: Pneumothorax is one complication of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS-TBB). We sought to clarify the risk factors for pneumothorax after EBUS-GS-TBB under fluoroscopic guidance. METHODS: We retrospectively reviewed data from 916 patients who underwent EBUS-GS-TBB at Fujita Health University Hospital. We evaluated the following risk factors for pneumothorax after EBUS-GS-TBB: patient characteristics (sex, age, and pulmonary comorbidities); lesion data (location, size, existence of ground-glass opacities [GGOs], pleural involvement, computed tomography [CT] bronchus sign, visibility on fluoroscopy, and EBUS findings); final diagnosis; years of bronchoscopist experience; and guide sheath size. Univariate and multivariate logistic regression analyses were performed. RESULTS: Among the 916 patients, 30 (3.28%) presented with pneumothorax. With a univariate analysis, factors that independently predisposed to pneumothorax included lesions containing GGOs, lesions in sagittal lung segments on fluoroscopy, lesions that were not visible on fluoroscopy, and infectious lesions. A univariate analysis also showed that lesions in the right upper lobe or left upper division, as well as malignant lesions, were less likely to lead to pneumothorax. Age, underlying pulmonary disease, CT bronchus sign, EBUS findings, bronchoscopist experience, and guide sheath size did not influence the incidence of pneumothorax. A multivariate analysis revealed that only lesions containing GGOs (odds ratio [OR] 6.47; 95% confidence interval [CI] 2.13-19.6, P = 0.001) and lesions in lung segments with a sagittal orientation on fluoroscopy (OR 2.47; 95% CI 1.09-5.58, P = 0.029) were significant risk factors for EBUS-GS-TBB-related pneumothorax. CONCLUSIONS: EBUS-GS-TBB of lesions containing GGOs or lesions located in sagittal lung segments on fluoroscopy correlate with a higher pneumothorax risk.

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  24. Inherited chromosomally integrated human herpesvirus 6 is a risk factor for spontaneous abortion. Reviewed International journal

    Hiroki Miura, Yoshiki Kawamura, Tamae Ohye, Fumihiko Hattori, Kei Kozawa, Masaru Ihira, Hiroshi Yatsuya, Haruki Nishizawa, Hiroki Kurahashi, Tetsushi Yoshikawa

    The Journal of infectious diseases   Vol. 223 ( 10 ) page: 1717 - 1723   2021.5

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    BACKGROUND: Human herpesvirus 6 (HHV-6) can be genetically transmitted from parent to child as inherited chromosomally integrated HHV-6 (iciHHV-6). HHV-6 reactivation occurs in pregnant women with iciHHV-6. We showed no gender differences in the frequency of index cases with iciHHV-6 but inheritance from the father was more common. We evaluated the association between iciHHV-6 status and spontaneous abortion. METHODS: iciHHV-6 was confirmed by high viral DNA copy numbers in whole blood and somatic cells. The origin of integrated viral genome, paternal or maternal, was examined using the same method. The pregnancy history of 23 mothers in families with iciHHV-6 and 285 mothers in families without iciHHV-6 was abstracted. RESULTS: Of 23 iciHHV-6 index cases, eight mothers and 15 fathers had iciHHV-6. Spontaneous abortion rates in mothers with and mothers without/fathers with iciHHV-6 and mothers in families without iciHHV-6 were 27.6%, 10.3%, and 14.8%, respectively (p = 0.012). Mother with iciHHV-6 (OR 6.41, 95%CI 1.10-37.4) and maternal age at the most recent pregnancy ≥40 years (OR 3.91, 95%CI 1.30-11.8) are associated with two or more spontaneous abortions. CONCLUSION: Mothers with iciHHV-6 is a risk factor for spontaneous abortion.

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  25. Prevalence of and factors associated with dilated choroidal vessels beneath the retinal pigment epithelium among the Japanese.

    Ito Y, Ito M, Iwase T, Kataoka K, Yamada K, Yasuda S, Ito H, Takeuchi J, Nakano Y, Fujita A, Horiguchi E, Taki Y, Yatsuya H, Terasaki H

    Scientific reports   Vol. 11 ( 1 ) page: 11278   2021.5

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    Pachyvessels are pathologically dilated large choroidal vessels and are associated with the pathogenesis of several pachychoroid-related disorders, including central serous chorioretinopathy. We aimed to investigate the prevalence of and risk factors for pachyvessels in the Japanese population. We included 316 participants (aged ≥ 40 years) with normal right eyes. The presence of pachyvessels (vertical diameter > 300 µm, distance to the retinal pigment epithelium < 50 µm) was determined using 6 × 6 mm macular swept-source optical coherence tomography images, and associated risk factors were investigated. Subfoveal choroidal thickness was measured, and its associated risk factors investigated. The overall prevalence of pachychoroids was 9.5%. Regression analysis showed that a younger age, shorter axial length, male sex, and smoking were significantly associated with the presence of pachyvessels (p = 0.047; odds ratio [OR] 0.96 per year, p = 0.021; OR 0.61 per 1 mm, p = 0.012; OR 3.08 vs. female, and p = 0.011; OR 3.15 vs. non-smoker, respectively) and greater choroidal thickness (p < 0.001, p < 0.001, p < 0.003, and p < 0.017, respectively). The results were consistent with other research findings which showed that pachychoroid-related disorders such as central serous chorioretinopathy were associated with younger age, male sex, shorter axial length, and smoking. Smoking may be associated with choroidal circulatory disturbance in the Japanese population.

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  26. Relationship between fasting blood glucose levels in middle age and cognitive function in later life: The Aichi Workers’ Cohort Study

    Masako Shimoda, Kayo Kaneko, Takeshi Nakagawa, Naoko Kawano, Rei Otsuka, Atsuhiko Ota, Hisao Naito, Masaaki Matsunaga, Naohiro Ichino, Hiroya Yamada, Chifa Chiang, Yoshihisa Hirakawa, Koji Tamakoshi, Atsuko Aoyama, Hiroshi Yatsuya

    Journal of Epidemiology   Vol. advpub ( 0 )   2021.5

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    <p><b>Background:</b> There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) in later life, following over 15 years of follow-up in the Aichi Workers’ Cohort Study in Japan.</p><p><b>Methods:</b> Participants were 253 former local government employees aged 60–79 years in 2018 who participated in a baseline survey conducted in 2002. Using baseline FBG levels and self-reported history, participants were classified into the normal, impaired fasting glucose (IFG) and, and DM groups. Total MoCA-J score ranges from 0 to 30, and cognitive impairment was defined as MoCA-J score ≤25 in this study. A general linear model was used to estimate the mean MoCA-J scores in the FBG groups, adjusted for age, sex, educational year, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, total cholesterol, and estimated glomerular filtration rate.</p><p><b>Results:</b> The mean MoCA-J score in the total population was 25.0, and the prevalence of MoCA-J score ≤25 was 49.0%. Multivariable-adjusted total MoCA-J scores were 25.2, 24.8, and 23.4 in the normal, IFG, and DM groups, respectively. The odds ratio of MoCA-J score ≤25 in the DM group was 3.29.</p><p><b>Conclusions:</b> FBG level in middle age was negatively associated with total MoCA-J scores assessed later in life, independent of confounding variables.</p>

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  27. Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study. Reviewed

    Tomomi Kihara, Kazumasa Yamagishi, Kazufumi Honda, Ai Ikeda, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Taiki Yamaji, Taichi Shimazu, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

    Journal of atherosclerosis and thrombosis   Vol. 28 ( 5 ) page: 483 - 490   2021.5

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    AIM: The fact that low concentrations of high-density lipoprotein cholesterol are associated with the risk of cardiovascular disease is well known, but high-density lipoprotein metabolism has not been fully understood. Apolipoprotein A2 (ApoA2) is the second-most dominant apolipoprotein of high-density lipoprotein. We tested the hypothesis that ApoA2 isoforms are inversely associated with myocardial infarction. METHODS: We measured the plasma levels of three ApoA2 isoforms (ApoA2-ATQ/ATQ, ApoA2-ATQ/AT, ApoA2-AT/AT) in nested case-control study samples of 1:2 from the Japan Public Health-Center-based Study (JPHC Study): 106 myocardial infarction incidence cases and 212 controls. RESULTS: ApoA2-AT/AT was inversely associated with risk of myocardial infarction, in a matched model (OR, 2.78; 95% CI, 1.26-6.09 for lowest compared with the highest quartile), but its association was attenuated after adjustment for smoking only (OR=2.13; 95% CI, 0.91-4.97) or drinking only (OR=2.07; 0.91-4.74), and the multivariable OR was 1.20 (95% CI, 0.41-3.57). Neither ApoA2-ATQ/ATQ nor ApoA2-ATQ/AT was associated with the risk of myocardial infarction. CONCLUSIONS: Our nested case-control study did not show a significant association of ApoA2 isoforms with a risk of myocardial infarction.

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  28. Perceptions and behaviors related to noncommunicable diseases in Palau: a qualitative study.

    Shimizu H, Hirakawa Y, Chiang C, Ngiralmau B, Tellei J, Rehuher-Marugg FK, Mita T, Yatsuya H, Aoyama A

    Nagoya journal of medical science   Vol. 83 ( 2 ) page: 287 - 298   2021.5

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    The increasing burden of noncommunicable diseases (NCDs) is a major public health concern in Palau. This study aims to identify social and psychological factors related to NCDs among Palauan people using a qualitative approach. We conducted eight key informant interviews and eight focus group discussions, which were audio-recorded, transcribed and translated into English. Ideas of the respondents were extracted and labeled, and the labels were analyzed using an inductive multistage approach referred to as qualitative content analysis. Three themes emerged: (1) home education, (2) traditional local community, and (3) modernization and westernization of lifestyle. Respondents believed that the influence of the family on lifestyle was significant, but that disciplining children at home had become difficult. They considered that the traditional lifestyle was mostly healthy, and were reluctant to abandon certain unhealthy customs, such as serving abundant food to guests as a sign of fraternity. They also thought that they overate because of their stressful modernized lifestyle. This is the first qualitative study to analyze perception and behavior of the Palauan people in relation to NCDs. We found that the increase in NCDs was related to two concurrent trends: preserving certain traditional customs unfavorable to good health, and abandoning time-consuming healthy traditional lifestyle to adopt a modernized one. We also found that Palauan people were not confident in their ability to prevent NCDs. Therefore, health promotion activities should be designed to empower people to make positive changes.

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  29. Weight change during middle age and risk of stroke and coronary heart disease: The Japan Public Health Center-based Prospective Study. International journal

    Koichi Kisanuki, Isao Muraki, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

    Atherosclerosis   Vol. 322   page: 67 - 73   2021.4

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    BACKGROUND AND AIMS: The impact of weight changes in middle age on the incidence of cardiovascular disease has not been well elucidated. We investigated whether a 5-year weight change was associated with risk of stroke and coronary heart disease (CHD) in middle-aged individuals. METHODS: We analyzed data of 74,928 participants aged 40-69 years who provided responses to the baseline and 5-year follow-up questionnaires in the Japan Public Health Center-based Prospective Study. Weight change was calculated by subtracting self-reported weight at baseline from that at 5-year follow-up. Stroke and CHD events were confirmed by reviewing hospital records. RESULTS: During 997,406 person-years of follow-up, we documented 3,975 stroke and 914 CHD events. The multivariable HRs of stroke for losing ≥5 kg compared to stable weight (change ≤2 kg) was 1.17 (95% CI, 1.01-1.37) in men versus 1.33 (1.13-1.57) for losing ≥5 kg and 1.61 (1.36-1.92) for gaining ≥5 kg in women (U-shaped association). These associations did not change after the exclusion of early events. The multivariable HR of CHD for gaining ≥5 kg was 1.22 (0.95-1.58) in men. After exclusion of early events within another 5 years, that positive association became stronger [multivariable HR 1.34 (1.00-1.82)]. CONCLUSIONS: Weight gain during middle age was associated with an increased risk of stroke in women and an increased risk of CHD in men. Weight loss was associated with an increased risk of stroke in both men and women.

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  30. Avoid clinical inertia: importance of asking and advising patients with diabetes who smoke about quitting. Reviewed

    Hiroshi Yatsuya

    Journal of diabetes investigation   Vol. 12 ( 3 ) page: 317 - 319   2021.3

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    The goal of diabetes care is to prevent complications and maximize quality of life of the patients. Evidence-based glycemic control is the centerpiece for achieving that goal. At the same time, more emphasis should also be put on managing other risk factors. A recent study published in Lancet Diabetes and Endocrinology confirmed that we should ask all the patients with diabetes whether they smoke, and if so, we should advise them to stop smoking immediately1 .

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  31. Factors Associated With Prediabetes and Diabetes Among Public Employees in Northern Ethiopia. Reviewed International coauthorship International journal

    Yupeng He, Chifa Chiang, Lemlem Weldegerima Gebremariam, Yoshihisa Hirakawa, Hiroshi Yatsuya, Atsuko Aoyama

    Asia-Pacific journal of public health   Vol. 33 ( 2-3 ) page: 242 - 250   2021.3

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    The increasing burden of diabetes mellitus is one of the major public health challenges in African countries, including Ethiopia. This is the first study aimed to identify factors associated with prediabetes and diabetes defined by both fasting blood glucose and glycated hemoglobin in Ethiopians. We analyzed data of a cross-sectional survey (1372 adults aged 25-64 years) conducted between October 2015 and February 2016; multinomial logistic regression models were applied. Abdominal obesity, total cholesterol, and non-high-density lipoprotein cholesterol were independently associated with prediabetes and diabetes in both sexes. Increased triglycerides and religious fasting practices were independently associated with prediabetes and diabetes only in men; hypertension was associated with prediabetes and diabetes only in women, while high-density lipoprotein cholesterol was not associated with prediabetes and diabetes in either sex. Sex differences in the association of triglycerides, hypertension, and dietary habit suggest that different approaches of lifestyle modification may be required for men and women.

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  32. Determinants of alcohol consumption and marijuana use among young adults in the Republic of Palau Reviewed International coauthorship

    Mizuki Sata, Renzhe Cui, Chifa Chiang, Singeru Travis Singeo, Berry Moon Watson, Hiroshi Yatsuya, Kaori Honjo, Takashi Mita, Everlynn Joy Temengil, Sherilynn Madraisau, Kazumasa Yamagishi, Atsuko Aoyama, Hiroyasu Iso

    Environmental Health and Preventive Medicine   Vol. 26 ( 1 ) page: 12   2021.1

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    <title>Abstract</title><sec>
    <title>Background</title>
    This study aimed to describe the status of alcohol consumption and drug use among young adults as well as their determinants.


    </sec><sec>
    <title>Methods</title>
    We conducted a cross-sectional study of 356 young adults (aged 18 to 24 years) living in Palau in 2013. The prevalence of self-reported alcohol and marijuana usage were compared within and between sexes, age groups, ethnicities, and education levels.


    </sec><sec>
    <title>Results</title>
    The proportion of current drinking was higher in people aged 21–24 than in those aged 18–20 (73.2% vs. 60.9%, <italic>p</italic> = 0.09 in men and 48.3% vs. 30.0%, <italic>p</italic> = 0.02 in women), while that of marijuana use did not differ between the age groups. The proportions of current drinking and marijuana use were higher in Palauan than in other ethnicities (current drinking: 70.6% vs. 40.6%, <italic>p</italic> = 0.005 in men and 38.8% vs. 16.6%, <italic>p</italic> = 0.04 in women; lifetime marijuana use: 80.0% vs. 52.9%, <italic>p</italic> = 0.02 in men and 56.1% vs. 30.6%, <italic>p</italic> = 0.09 in women). The proportion of frequent (3 times or more) marijuana users was higher for the lower educated than for the higher educated (62.5% vs. 32.1%, <italic>p</italic> &lt; 0.001 in men and 33.9% vs. 24.4%, <italic>p</italic> = 0.12 in women).


    </sec><sec>
    <title>Conclusions</title>
    Sex, age, ethnicity, and education were significant determinants of alcohol and marijuana use.


    </sec>

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    Other Link: http://link.springer.com/article/10.1186/s12199-020-00928-8/fulltext.html

  33. Health of university students under job and financial insecurity during COVID-19 pandemic

    Yatsuya Hiroshi, Ishitake Tatsuya

    Journal of Occupational Health   Vol. 63 ( 1 ) page: e12223   2021.1

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  34. Work-related factors among people with diabetes and the risk of cardiovascular diseases: A systematic review

    Saif-Ur-Rahman KM, Mamun Razib, Li Yuanying, Matsunaga Masaaki, Ota Atsuhiko, Yatsuya Hiroshi

    Journal of Occupational Health   Vol. 63 ( 1 ) page: e12278   2021.1

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    <p><b>Background</b>: Diabetes is a major risk factor for cardiovascular diseases (CVD). This systematic review aims to explore the work-related factors among people with diabetes in developing CVD.</p><p><b>Methods</b>: Four electronic databases were searched on 1 February 2021 using a comprehensive search strategy without any time restriction. Two independent researchers screened the articles and extracted data. The risk of bias was assessed independently using the risk of bias assessment tool for non-randomized studies (RoBANS). A narrative synthesis was conducted considering the heterogeneity of the included articles.</p><p><b>Results</b>: A total of five articles incorporating 4 409 810 participants from three geographic regions were included that highlights the research gap. As per the included studies, Occupational drivers with diabetes were at a higher risk of CVD in comparison to the nondrivers, workers with diabetes having a long working hour were at a higher risk of CVD mortality, workers with a lower occupational status were at a higher risk of 10-years stroke risk, and occupational physical activity and occupational commuting lowered the risk of CVD deaths.</p><p><b>Conclusions</b>: This systematic review summarized the available evidence on work-related factors influencing the risk of CVD in people with diabetes. The findings should be interpreted cautiously pondering the limited evidence and imprecision. We identified only five articles related to the topic, and there were no studies from Japan. The scarcity of studies on work-related factors on the prognosis of diabetic patients implies the need for more research in this field. We recommend further exploration of the topic designing primary studies.</p>

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  35. Global, regional, and national burden of stroke and its risk factors, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019

    Feigin V.L., Stark B.A., Johnson C.O., Roth G.A., Bisignano C., Abady G.G., Abbasifard M., Abbasi-Kangevari M., Abd-Allah F., Abedi V., Abualhasan A., Abu-Rmeileh N.M.E., Abushouk A.I., Adebayo O.M., Agarwal G., Agasthi P., Ahinkorah B.O., Ahmad S., Ahmadi S., Salih Y.A., Aji B., Akbarpour S., Akinyemi R.O., Al Hamad H., Alahdab F., Alif S.M., Alipour V., Aljunid S.M., Almustanyir S., Al-Raddadi R.M., Salman R.A.S., Alvis-Guzman N., Ancuceanu R., Anderlini D., Anderson J.A., Ansar A., Antonazzo I.C., Arabloo J., Ärnlöv J., Artanti K.D., Aryan Z., Asgari S., Ashraf T., Athar M., Atreya A., Ausloos M., Baig A.A., Baltatu O.C., Banach M., Barboza M.A., Barker-Collo S.L., Bärnighausen T.W., Barone M.T.U., Basu S., Bazmandegan G., Beghi E., Beheshti M., Béjot Y., Bell A.W., Bennett D.A., Bensenor I.M., Bezabhe W.M., Bezabih Y.M., Bhagavathula A.S., Bhardwaj P., Bhattacharyya K., Bijani A., Bikbov B., Birhanu M.M., Boloor A., Bonny A., Brauer M., Brenner H., Bryazka D., Butt Z.A., Dos Santos F.L.C., Campos-Nonato I.R., Cantu-Brito C., Carrero J.J., Castañeda-Orjuela C.A., Catapano A.L., Chakraborty P.A., Charan J., Choudhari S.G., Chowdhury E.K., Chu D.T., Chung S.C., Colozza D., Costa V.M., Costanzo S., Criqui M.H., Dadras O., Dagnew B., Dai X., Dalal K., Damasceno A.A.M., D'Amico E., Dandona L., Dandona R., Gela J.D.

    The Lancet Neurology   Vol. 20 ( 10 ) page: 1 - 26   2021

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    Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.

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  36. Depressive Tendency and the Risk of Death from Pneumonia: The JACC Study. Reviewed

    Naohito Tanabe, Nao Seki, Chika Horikawa, Hiroshi Yatsuya, Kazumasa Yamagishi, Hiroyasu Iso, Shigekazu Ukawa, Akiko Tamakoshi

    Internal medicine (Tokyo, Japan)   Vol. 59 ( 24 ) page: 3123 - 3130   2020.12

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    Objective The burden of death from pneumonia is expected to increase with the aging of the population, as has been observed in Japan. Depressive tendency, a common psychosocial sign, may be a risk factor for pneumonia due to its possible association with some immune dysfunction. This study aimed to clarify the association between depressive tendency and the risk of death from pneumonia. Methods A population-based cohort that consisted of 75,174 Japanese men and women was followed for a median of 19.1 years. Four psychological and behavioral symptoms (depressive symptoms) were used to evaluate depressive tendency. Results A total of 1,329 deaths from pneumonia were observed. Depressive symptoms were positively and dose-dependently associated with the risk of death from pneumonia (P<0.001 for trend), and subjects with ≥2 depressive symptoms showed a significantly elevated risk compared to those without any symptoms (multivariable hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.39-1.99). This association was not significantly affected by sex or age at baseline. The elevated risk was still significant even when subjects were limited to those without any medical histories. The excess risk was observed not only for death occurring within the first 10 years of follow-up (multivariable HR, 2.05; 95% CI, 1.51-2.78) but also for that occurring in the longer follow-up period (multivariable HR, 1.48; 95% CI, 1.18-1.85). Conclusion Depressive tendency may be a risk factor for death from pneumonia. Further studies using a more reliable tool for the evaluation of depressive state are necessary to confirm this relationship.

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  37. Pelvic exenteration associated with future renal dysfunction. Reviewed

    Masanori Sando, Kay Uehara, Yuanying Li, Toshisada Aiba, Atsushi Ogura, Tomoki Ebata, Yasuhiro Kodera, Hiroshi Yatsuya, Masato Nagino

    Surgery today   Vol. 50 ( 12 ) page: 1601 - 1609   2020.12

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    PURPOSE: This study aimed to clarify the long-term change in the renal function after pelvic exenteration (PE) and to evaluate the risk factors for any future dysfunction. METHODS: This study comprised 40 patients. A greater than 25% decline in the estimated glomerular filtration rate (eGFR) at 3 years was defined as early renal function disorder (ERFD), possibly predicting future chronic kidney disease (CKD). RESULTS: In the entire cohort, the median eGFR decreased by 23% at 3 years, and CKD developed in 50%. The patients were divided into the ERFD (n = 16) and non-ERFD (n = 24) groups. In the ERFD group, the eGFR significantly decreased by 28% during the first 1.5 years and continued to decline after that, resulting in 81.3% of patients reaching CKD, whereas it was 4% and 37.5%, respectively, in the non-ERFD group. In a growth model analysis, late urinary tract complications (UTC) and small bowel obstruction were shown to be risk factors for ERFD. CONCLUSION: Although PE was associated with a high incidence of future CKD, ERFD could predict it. Close observation of the eGFR decline over 1.5 years might be beneficial to identify ERFD patients. High-risk patients with late UTC and small bowel obstruction should, therefore, be observed carefully.

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  38. Increased risk of occupational trichloroethylene hypersensitivity syndrome at exposure levels higher than 15 mg/L of urinary trichloroacetic acid, regardless of whether the patients had the HLA-B*13:01 allele. Reviewed International coauthorship International journal

    Hailan Wang, Tamie Nakajima, Yuki Ito, Hisao Naito, Na Zhao, Hongling Li, Xinxiang Qiu, Lihua Xia, Jiabin Chen, Qifeng Wu, Laiyu Li, Hanlin Huang, Yukie Yanagiba, Hongyung Qu, Hiroshi Yatsuya, Michihiro Kamijima

    Environmental research   Vol. 191   page: 109972 - 109972   2020.12

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    Occupational trichloroethylene (TCE) exposure can cause hypersensitivity syndrome (TCE-HS). The human leukocyte antigen (HLA)-B*13:01 is reportedly an important allele involved in TCE-HS onset. However, the threshold exposure level causing TCE-HS in relation to HLA-B*13:01 remains unknown. We conducted a case-control study comprising 37 TCE-HS patients and 97 age- and sex-matched TCE-tolerant controls from the Han Chinese population. Urine and blood of patients were collected on the first day of hospitalization, and those of controls were collected at the end of their shifts. Urinary trichloroacetic acid (TCA) was measured as an exposure marker, and end-of-shift levels in the patients were estimated using the biological half-life of 83.7 h. HLA-B genotype was identified using DNA from blood. Crude odds ratios (ORs) for TCE-HS in the groups with urinary TCA concentration >15 mg/L to ≤50 mg/L and of >50 mg/L were 21.9 [95% confidence interval (CI) 4.2-114.1] and 27.6 (6.1-125.8), respectively, when the group with urinary TCA ≤15 mg/L was used as a reference. The frequency of HLA-B*13:01, the most common allele in the patients, was 62.2% (23/37), which was significantly higher than 17.5% (17/97) in the TCE-tolerant controls, with a crude OR of 8.4 (3.1-22.6). The mutually-adjusted ORs for urinary TCA >15 to ≤50 mg/L, >50 mg/L, and for HLA-B*13:01 were 33.4 (4.1-270.8), 34.0 (5.3-217.1), and 11.0 (2.4-50.7), respectively. In conclusion, reduction of TCE exposure to ≤15 mg/L is required for TCE-HS prevention because urinary TCA concentration >15 mg/L showed increased risk of TCE-HS, regardless of whether the patients had the HLA-B*13:01 allele.

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  39. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

    Gregory A. Roth, George A. Mensah, Catherine O. Johnson, Giovanni Addolorato, Enrico Ammirati, Larry M. Baddour, Noël C. Barengo, Andrea Z. Beaton, Emelia J. Benjamin, Catherine P. Benziger, Aimé Bonny, Michael Brauer, Marianne Brodmann, Thomas J. Cahill, Jonathan Carapetis, Alberico L. Catapano, Sumeet S. Chugh, Leslie T. Cooper, Josef Coresh, Michael Criqui, Nicole DeCleene, Kim A. Eagle, Sophia Emmons-Bell, Valery L. Feigin, Joaquim Fernández-Solà, Gerry Fowkes, Emmanuela Gakidou, Scott M. Grundy, Feng J. He, George Howard, Frank Hu, Lesley Inker, Ganesan Karthikeyan, Nicholas Kassebaum, Walter Koroshetz, Carl Lavie, Donald Lloyd-Jones, Hong S. Lu, Antonio Mirijello, Awoke Misganaw Temesgen, Ali Mokdad, Andrew E. Moran, Paul Muntner, Jagat Narula, Bruce Neal, Mpiko Ntsekhe, Glaucia Moraes de Oliveira, Catherine Otto, Mayowa Owolabi, Michael Pratt, Sanjay Rajagopalan, Marissa Reitsma, Antonio Luiz P. Ribeiro, Nancy Rigotti, Anthony Rodgers, Craig Sable, Saate Shakil, Karen Sliwa-Hahnle, Benjamin Stark, Johan Sundström, Patrick Timpel, Imad M. Tleyjeh, Marco Valgimigli, Theo Vos, Paul K. Whelton, Magdi Yacoub, Liesl Zuhlke, Christopher Murray, Valentin Fuster, Gregory A. Roth, George A. Mensah, Catherine O. Johnson, Giovanni Addolorato, Enrico Ammirati, Larry M. Baddour, Noel C. Barengo, Andrea Beaton, Emelia J. Benjamin, Catherine P. Benziger, Aime Bonny, Michael Brauer, Marianne Brodmann, Thomas J. Cahill, Jonathan R. Carapetis, Alberico L. Catapano, Sumeet Chugh, Leslie T. Cooper, Josef Coresh, Michael H. Criqui, Nicole K. DeCleene, Kim A. Eagle, Sophia Emmons-Bell, Valery L. Feigin, Joaquim Fernández-Sola, F. Gerry R. Fowkes, Emmanuela Gakidou, Scott M. Grundy, Feng J. He, George Howard, Frank Hu, Lesley Inker, Ganesan Karthikeyan, Nicholas J. Kassebaum, Walter J. Koroshetz, Carl Lavie, Donald Lloyd-Jones, Hong S. Lu, Antonio Mirijello, Awoke T. Misganaw, Ali H. Mokdad, Andrew E. Moran, Paul Muntner, Jagat Narula, Bruce Neal, Mpiko Ntsekhe, Gláucia M.M. Oliveira, Catherine M. Otto, Mayowa O. Owolabi, Michael Pratt, Sanjay Rajagopalan, Marissa B. Reitsma, Antonio Luiz P. Ribeiro, Nancy A. Rigotti, Anthony Rodgers, Craig A. Sable, Saate S. Shakil, Karen Sliwa, Benjamin A. Stark, Johan Sundström, Patrick Timpel, Imad I. Tleyjeh, Marco Valgimigli, Theo Vos, Paul K. Whelton, Magdi Yacoub, Liesl J. Zuhlke, Mohsen Abbasi-Kangevari, Alireza Abdi, Aidin Abedi, Victor Aboyans, Woldu A. Abrha, Eman Abu-Gharbieh, Abdelrahman I. Abushouk, Dilaram Acharya, Tim Adair, Oladimeji M. Adebayo, Zanfina Ademi, Shailesh M. Advani, Khashayar Afshari, Ashkan Afshin, Gina Agarwal, Pradyumna Agasthi, Sohail Ahmad, Sepideh Ahmadi, Muktar B. Ahmed, Budi Aji, Yonas Akalu, Wuraola Akande-Sholabi, Addis Aklilu, Chisom J. Akunna, Fares Alahdab, Ayman Al-Eyadhy, Khalid F. Alhabib, Sheikh M. Alif, Vahid Alipour, Syed M. Aljunid, François Alla, Amir Almasi-Hashiani, Sami Almustanyir, Rajaa M. Al-Raddadi, Adeladza K. Amegah, Saeed Amini, Arya Aminorroaya, Hubert Amu, Dickson A. Amugsi, Robert Ancuceanu, Deanna Anderlini, Tudorel Andrei, Catalina Liliana Andrei, Alireza Ansari-Moghaddam, Zelalem A. Anteneh, Ippazio Cosimo Antonazzo, Benny Antony, Razique Anwer, Lambert T. Appiah, Jalal Arabloo, Johan Ärnlöv, Kurnia D. Artanti, Zerihun Ataro, Marcel Ausloos, Leticia Avila-Burgos, Asma T. Awan, Mamaru A. Awoke, Henok T. Ayele, Muluken A. Ayza, Samad Azari, Darshan B. B, Nafiseh Baheiraei, Atif A. Baig, Ahad Bakhtiari, Maciej Banach, Palash C. Banik, Emerson A. Baptista, Miguel A. Barboza, Lingkan Barua, Sanjay Basu, Neeraj Bedi, Yannick Béjot, Derrick A. Bennett, Isabela M. Bensenor, Adam E. Berman, Yihienew M. Bezabih, Akshaya S. Bhagavathula, Sonu Bhaskar, Krittika Bhattacharyya, Ali Bijani, Boris Bikbov, Mulugeta M. Birhanu, Archith Boloor, Luisa C. Brant, Hermann Brenner, Nikolay I. Briko, Zahid A. Butt, Florentino Luciano Caetano dos Santos, Leah E. Cahill, Lucero Cahuana-Hurtado, Luis A. Cámera, Ismael R. Campos-Nonato, Carlos Cantu-Brito, Josip Car, Juan J. Carrero, Felix Carvalho, Carlos A. Castañeda-Orjuela, Ferrán Catalá-López, Ester Cerin, Jaykaran Charan, Vijay Kumar Chattu, Simiao Chen, Ken L. Chin, Jee-Young J. Choi, Dinh-Toi Chu, Sheng-Chia Chung, Massimo Cirillo, Sean Coffey, Sara Conti, Vera M. Costa, David K. Cundiff, Omid Dadras, Baye Dagnew, Xiaochen Dai, Albertino A.M. Damasceno, Lalit Dandona, Rakhi Dandona, Kairat Davletov, Vanessa De la Cruz-Góngora, Fernando P. De la Hoz, Jan-Walter De Neve, Edgar Denova-Gutiérrez, Meseret Derbew Molla, Behailu T. Derseh, Rupak Desai, Günther Deuschl, Samath D. Dharmaratne, Meghnath Dhimal, Raja Ram Dhungana, Mostafa Dianatinasab, Daniel Diaz, Shirin Djalalinia, Klara Dokova, Abdel Douiri, Bruce B. Duncan, Andre R. Duraes, Arielle W. Eagan, Sanam Ebtehaj, Aziz Eftekhari, Sahar Eftekharzadeh, Michael Ekholuenetale, Nevine El Nahas, Islam Y. Elgendy, Muhammed Elhadi, Shaimaa I. El-Jaafary, Sadaf Esteghamati, Atkilt E. Etisso, Oghenowede Eyawo, Ibtihal Fadhil, Emerito Jose A. Faraon, Pawan S. Faris, Medhat Farwati, Farshad Farzadfar, Eduarda Fernandes, Carlota Fernandez Prendes, Pietro Ferrara, Irina Filip, Florian Fischer, David Flood, Takeshi Fukumoto, Mohamed M. Gad, Shilpa Gaidhane, Morsaleh Ganji, Jalaj Garg, Abadi K. Gebre, Birhan G. Gebregiorgis, Kidane Z. Gebregzabiher, Gebreamlak G. Gebremeskel, Lemma Getacher, Abera Getachew Obsa, Alireza Ghajar, Ahmad Ghashghaee, Nermin Ghith, Simona Giampaoli, Syed Amir Gilani, Paramjit S. Gill, Richard F. Gillum, Ekaterina V. Glushkova, Elena V. Gnedovskaya, Mahaveer Golechha, Kebebe B. Gonfa, Amir Hossein Goudarzian, Alessandra C. Goulart, Jenny S. Guadamuz, Avirup Guha, Yuming Guo, Rajeev Gupta, Vladimir Hachinski, Nima Hafezi-Nejad, Teklehaimanot G. Haile, Randah R. Hamadeh, Samer Hamidi, Graeme J. Hankey, Arief Hargono, Risky K. Hartono, Maryam Hashemian, Abdiwahab Hashi, Shoaib Hassan, Hamid Y. Hassen, Rasmus J. Havmoeller, Simon I. Hay, Khezar Hayat, Golnaz Heidari, Claudiu Herteliu, Ramesh Holla, Mostafa Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Mowafa Househ, Junjie Huang, Ayesha Humayun, Ivo Iavicoli, Charles U. Ibeneme, Segun E. Ibitoye, Olayinka S. Ilesanmi, Irena M. Ilic, Milena D. Ilic, Usman Iqbal, Seyed Sina N. Irvani, Sheikh Mohammed Shariful Islam, Rakibul M. Islam, Hiroyasu Iso, Masao Iwagami, Vardhmaan Jain, Tahereh Javaheri, Sathish Kumar Jayapal, Shubha Jayaram, Ranil Jayawardena, Panniyammakal Jeemon, Ravi P. Jha, Jost B. Jonas, Jitendra Jonnagaddala, Farahnaz Joukar, Jacek J. Jozwiak, Mikk Jürisson, Ali Kabir, Tanvir Kahlon, Rizwan Kalani, Rohollah Kalhor, Ashwin Kamath, Ibrahim Kamel, Himal Kandel, Amit Kandel, André Karch, Ayele Semachew Kasa, Patrick D.M.C. Katoto, Gbenga A. Kayode, Yousef S. Khader, Mohammad Khammarnia, Muhammad S. Khan, Md Nuruzzaman Khan, Maseer Khan, Ejaz A. Khan, Khaled Khatab, Gulam M.A. Kibria, Yun Jin Kim, Gyu Ri Kim, Ruth W. Kimokoti, Sezer Kisa, Adnan Kisa, Mika Kivimäki, Dhaval Kolte, Ali Koolivand, Vladimir A. Korshunov, Sindhura Lakshmi Koulmane Laxminarayana, Ai Koyanagi, Kewal Krishan, Vijay Krishnamoorthy, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Vaman Kulkarni, G. Anil Kumar, Nithin Kumar, Om P. Kurmi, Dian Kusuma, Gene F. Kwan, Carlo La Vecchia, Ben Lacey, Tea Lallukka, Qing Lan, Savita Lasrado, Zohra S. Lassi, Paolo Lauriola, Wayne R. Lawrence, Avula Laxmaiah, Kate E. LeGrand, Ming-Chieh Li, Bingyu Li, Shanshan Li, Stephen S. Lim, Lee-Ling Lim, Hualiang Lin, Ziqiang Lin, Ro-Ting Lin, Xuefeng Liu, Alan D. Lopez, Stefan Lorkowski, Paulo A. Lotufo, Alessandra Lugo, Nirmal K. M, Fabiana Madotto, Morteza Mahmoudi, Azeem Majeed, Reza Malekzadeh, Ahmad A. Malik, Abdullah A. Mamun, Navid Manafi, Mohammad Ali Mansournia, Lorenzo G. Mantovani, Santi Martini, Manu R. Mathur, Giampiero Mazzaglia, Suresh Mehata, Man Mohan Mehndiratta, Toni Meier, Ritesh G. Menezes, Atte Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Tomasz Miazgowski, Irmina Maria Michalek, Ted R. Miller, Erkin M. Mirrakhimov, Hamed Mirzaei, Babak Moazen, Masoud Moghadaszadeh, Yousef Mohammad, Dara K. Mohammad, Shafiu Mohammed, Mohammed A. Mohammed, Yaser Mokhayeri, Mariam Molokhia, Ahmed A. Montasir, Ghobad Moradi, Rahmatollah Moradzadeh, Paula Moraga, Lidia Morawska, Ilais Moreno Velásquez, Jakub Morze, Sumaira Mubarik, Walter Muruet, Kamarul Imran Musa, Ahamarshan J. Nagarajan, Mahdi Nalini, Vinay Nangia, Atta Abbas Naqvi, Sreenivas Narasimha Swamy, Bruno R. Nascimento, Vinod C. Nayak, Javad Nazari, Milad Nazarzadeh, Ruxandra I. Negoi, Sandhya Neupane Kandel, Huong L.T. Nguyen, Molly R. Nixon, Bo Norrving, Jean Jacques Noubiap, Brice E. Nouthe, Christoph Nowak, Oluwakemi O. Odukoya, Felix A. Ogbo, Andrew T. Olagunju, Hans Orru, Alberto Ortiz, Samuel M. Ostroff, Jagadish Rao Padubidri, Raffaele Palladino, Adrian Pana, Songhomitra Panda-Jonas, Utsav Parekh, Eun-Cheol Park, Mojtaba Parvizi, Fatemeh Pashazadeh Kan, Urvish K. Patel, Mona Pathak, Rajan Paudel, Veincent Christian F. Pepito, Arokiasamy Perianayagam, Norberto Perico, Hai Q. Pham, Thomas Pilgrim, Michael A. Piradov, Farhad Pishgar, Vivek Podder, Roman V. Polibin, Akram Pourshams, Dimas R.A. Pribadi, Navid Rabiee, Mohammad Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Amir Masoud Rahmani, Ivo Rakovac, Pradhum Ram, Sudha Ramalingam, Juwel Rana, Priyanga Ranasinghe, Sowmya J. Rao, Priya Rathi, Lal Rawal, Wasiq F. Rawasia, Reza Rawassizadeh, Giuseppe Remuzzi, Andre M.N. Renzaho, Aziz Rezapour, Seyed Mohammad Riahi, Ross L. Roberts-Thomson, Leonardo Roever, Peter Rohloff, Michele Romoli, Gholamreza Roshandel, Godfrey M. Rwegerera, Seyedmohammad Saadatagah, Maha M. Saber-Ayad, Siamak Sabour, Simona Sacco, Masoumeh Sadeghi, Sahar Saeedi Moghaddam, Saeed Safari, Amirhossein Sahebkar, Sana Salehi, Hamideh Salimzadeh, Mehrnoosh Samaei, Abdallah M. Samy, Itamar S. Santos, Milena M. Santric-Milicevic, Nizal Sarrafzadegan, Arash Sarveazad, Thirunavukkarasu Sathish, Monika Sawhney, Mete Saylan, Maria I. Schmidt, Aletta E. Schutte, Subramanian Senthilkumaran, Sadaf G. Sepanlou, Feng Sha, Saeed Shahabi, Izza Shahid, Masood A. Shaikh, Mahdi Shamali, Morteza Shamsizadeh, Md Shajedur Rahman Shawon, Aziz Sheikh, Mika Shigematsu, Min-Jeong Shin, Jae Il Shin, Rahman Shiri, Ivy Shiue, Kerem Shuval, Soraya Siabani, Tariq J. Siddiqi, Diego A.S. Silva, Jasvinder A. Singh, Ambrish Singh Mtech, Valentin Y. Skryabin, Anna A. Skryabina, Amin Soheili, Emma E. Spurlock, Leo Stockfelt, Stefan Stortecky, Saverio Stranges, Rizwan Suliankatchi Abdulkader, Hooman Tadbiri, Eyayou G. Tadesse, Degena B. Tadesse, Masih Tajdini, Md Tariqujjaman, Berhane F. Teklehaimanot, Mohamad-Hani Temsah, Ayenew K. Tesema, Bhaskar Thakur, Kavumpurathu R. Thankappan, Rekha Thapar, Amanda G. Thrift, Binod Timalsina, Marcello Tonelli, Mathilde Touvier, Marcos R. Tovani-Palone, Avnish Tripathi, Jaya P. Tripathy, Thomas C. Truelsen, Guesh M. Tsegay, Gebiyaw W. Tsegaye, Nikolaos Tsilimparis, Biruk S. Tusa, Stefanos Tyrovolas, Krishna Kishore Umapathi, Brigid Unim, Bhaskaran Unnikrishnan, Muhammad S. Usman, Muthiah Vaduganathan, Pascual R. Valdez, Tommi J. Vasankari, Diana Z. Velazquez, Narayanaswamy Venketasubramanian, Giang T. Vu, Isidora S. Vujcic, Yasir Waheed, Yanzhong Wang, Fang Wang, Jingkai Wei, Robert G. Weintraub, Abrha H. Weldemariam, Ronny Westerman, Andrea S. Winkler, Charles S. Wiysonge, Charles D.A. Wolfe, Befikadu Legesse Wubishet, Gelin Xu, Ali Yadollahpour, Kazumasa Yamagishi, Lijing L. Yan, Srikanth Yandrapalli, Yuichiro Yano, Hiroshi Yatsuya, Tomas Y. Yeheyis, Yigizie Yeshaw, Christopher S. Yilgwan, Naohiro Yonemoto, Chuanhua Yu, Hasan Yusefzadeh, Geevar Zachariah, Sojib Bin Zaman, Muhammed S. Zaman, Maryam Zamanian, Ramin Zand, Alireza Zandifar, Afshin Zarghi, Mikhail S. Zastrozhin, Anasthasia Zastrozhina, Zhi-Jiang Zhang, Yunquan Zhang, Wangjian Zhang, Chenwen Zhong, Zhiyong Zou, Yves Miel H. Zuniga, Christopher J.L. Murray, Valentin Fuster

    Journal of the American College of Cardiology   Vol. 76 ( 25 ) page: 2982 - 3021   2020.12

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    DOI: 10.1016/j.jacc.2020.11.010

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  40. Inherited chromosomally integrated human herpesvirus 6 and autoimmune connective tissue diseases. Reviewed International journal

    Yoshiki Kawamura, Takako Hashimoto, Hiroki Miura, Kei Kozawa, Akiko Yoshikawa, Naomi Ikeda, Hiroshi Yatsuya, Hidekata Yasuoka, Tetsushi Yoshikawa

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology   Vol. 132   page: 104656 - 104656   2020.11

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    BACKGROUND: Entire genome of human herpesvirus 6 (HHV-6) that integrates into human chromosomes is called chromosomally integrated HHV-6 (ciHHV-6). Several viral infections have been suggested to be involved in autoimmune connective tissue diseases (CTDs). Reactivated HHV-6 from the integrated viral genome can induce immune responses against the virus. Thus, it is plausible that ciHHV-6 is associated with autoimmune CTDs. OBJECTIVES: We sought to determine whether the prevalence of ciHHV-6 was significantly higher in patients with autoimmune CTDs than in a healthy population. STUDY DESIGN: A total of 846 peripheral blood samples collected from autoimmune CTD patients were analyzed. Since there was a large number of samples, they were pooled into 24 samples per group. Copy numbers of HHV-6 DNA were measured by real-time PCR. The threshold level for distinguishing between ciHHV-6 and active viral infection and the reliability of pooled DNA analysis were examined as initial validation experiments. RESULTS: The threshold level was 1.6 × 10^6 copy/mL in whole blood. The reliability of pooled DNA analysis to identify one ciHHV-6 sample among 23 HHV-6 DNA-negative samples was high. No HHV-6 DNA was detected in any of the pooled DNA samples collected from the patients. The probability of the present study including the 846 autoimmune CTD patient's samples was statistically not different with a healthy Japanese population which was 0.2 % or 0.6 %. CONCLUSIONS: There was no significant difference in the prevalence of ciHHV-6 between a healthy population and patients with autoimmune CTDs.

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  41. Positive Association of Physical Activity with Both Objective and Perceived Measures of the Neighborhood Environment among Older Adults: The Aichi Workers' Cohort Study. Reviewed International journal

    Yuanying Li, Hiroshi Yatsuya, Tomoya Hanibuchi, Atsuhiko Ota, Hisao Naito, Rei Otsuka, Chiyoe Murata, Yoshihisa Hirakawa, Chifa Chiang, Mayu Uemura, Koji Tamakoshi, Atsuko Aoyama

    International journal of environmental research and public health   Vol. 17 ( 21 ) page: 1 - 14   2020.10

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    We examined the association between objective and perceived neighborhood characteristics and self-reported leisure-time physical activity (PA) in older Japanese residents living in areas ranging from metropolitan to rural in 2016. Objective measures used were walkability and the numbers of parks/green spaces and sports facilities within 500 or 1000 m of subjects' homes, calculated using geographic information systems. Subjective measures were the subjects' perceptions of their neighborhoods, assessed using a structured questionnaire. All variables were divided into three groups, and the lowest tertile was used as the reference. We assessed the location and frequency of strolling or brisk walking, moderate-intensity PA, and vigorous-intensity PA (sports) using a self-reported questionnaire and defined as performing a certain type of PA 3-4 times/week as a habit. Living in a neighborhood in the highest tertile for walkability and number of parks/green spaces as well as perception of having good access to recreational facilities, observing others exercising and the presence of walkable sidewalks was associated with walking and sports habits (multivariable odds ratios (ORs): 1.33-2.46, all p < 0.05). Interestingly, objective measures of PA-friendly environmental features were inversely associated with moderate-intensity PA habits, potentially because moderate-intensity PA consisted predominantly of gardening. In conclusion, living in an environment supportive of PA, whether objectively or subjectively measured, is related to leisure-time PA habits among older Japanese adults.

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  42. Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets. Reviewed International coauthorship International journal

    Kunihiro Matsushita, Simerjot K Jassal, Yingying Sang, Shoshana H Ballew, Morgan E Grams, Aditya Surapaneni, Johan Arnlov, Nisha Bansal, Milica Bozic, Hermann Brenner, Nigel J Brunskill, Alex R Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai-Uwe Eckardt, Ron T Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih-Jen Hwang, Tazeen H Jafar, Takamasa Kayama, Csaba P Kovesdy, Gijs W Landman, Andrew S Levey, Donald M Lloyd-Jones, Rupert W Major, Katsuyuki Miura, Paul Muntner, Girish N Nadkarni, David Mj Naimark, Christoph Nowak, Takayoshi Ohkubo, Michelle J Pena, Kevan R Polkinghorne, Charumathi Sabanayagam, Toshimi Sairenchi, Markus P Schneider, Varda Shalev, Michael Shlipak, Marit D Solbu, Nikita Stempniewicz, James Tollitt, José M Valdivielso, Joep van der Leeuw, Angela Yee-Moon Wang, Chi-Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Elke Schaeffner, Josef Coresh

    EClinicalMedicine   Vol. 27   page: 100552 - 100552   2020.10

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    Background: Chronic kidney disease (CKD) measures (estimated glomerular filtration rate [eGFR] and albuminuria) are frequently assessed in clinical practice and improve the prediction of incident cardiovascular disease (CVD), yet most major clinical guidelines do not have a standardized approach for incorporating these measures into CVD risk prediction. "CKD Patch" is a validated method to calibrate and improve the predicted risk from established equations according to CKD measures. Methods: Utilizing data from 4,143,535 adults from 35 datasets, we developed several "CKD Patches" incorporating eGFR and albuminuria, to enhance prediction of risk of atherosclerotic CVD (ASCVD) by the Pooled Cohort Equation (PCE) and CVD mortality by Systematic COronary Risk Evaluation (SCORE). The risk enhancement by CKD Patch was determined by the deviation between individual CKD measures and the values expected from their traditional CVD risk factors and the hazard ratios for eGFR and albuminuria. We then validated this approach among 4,932,824 adults from 37 independent datasets, comparing the original PCE and SCORE equations (recalibrated in each dataset) to those with addition of CKD Patch. Findings: We confirmed the prediction improvement with the CKD Patch for CVD mortality beyond SCORE and ASCVD beyond PCE in validation datasets (Δc-statistic 0.027 [95% CI 0.018-0.036] and 0.010 [0.007-0.013] and categorical net reclassification improvement 0.080 [0.032-0.127] and 0.056 [0.044-0.067], respectively). The median (IQI) of the ratio of predicted risk for CVD mortality with CKD Patch vs. the original prediction with SCORE was 2.64 (1.89-3.40) in very high-risk CKD (e.g., eGFR 30-44 ml/min/1.73m2 with albuminuria ≥30 mg/g), 1.86 (1.48-2.44) in high-risk CKD (e.g., eGFR 45-59 ml/min/1.73m2 with albuminuria 30-299 mg/g), and 1.37 (1.14-1.69) in moderate risk CKD (e.g., eGFR 60-89 ml/min/1.73m2 with albuminuria 30-299 mg/g), indicating considerable risk underestimation in CKD with SCORE. The corresponding estimates for ASCVD with PCE were 1.55 (1.37-1.81), 1.24 (1.10-1.54), and 1.21 (0.98-1.46). Interpretation: The "CKD Patch" can be used to quantitatively enhance ASCVD and CVD mortality risk prediction equations recommended in major US and European guidelines according to CKD measures, when available. Funding: US National Kidney Foundation and the NIDDK.

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  43. Correction: The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes. Reviewed International journal

    Madoka Matsushita, Akiko Muramoto, Eri Nomura, Yukari Eguchi, Ayako Kato, Yoshiko Sano, Mai Kabayama, Masashi Arakawa, Yuko Oguma, Daisuke Yabe, Masaaki Matsunaga, Hiroshi Yatsuya, Hiroshi Arima, Kazuyo Tsushita

    Nutrition & diabetes   Vol. 10 ( 1 ) page: 34 - 34   2020.9

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    Following publication, the authors asked to add the following institution to the affiliations of author Madoka Matsushita: Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine Both the PDF and HTML versions of the Article have been updated accordingly.

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  44. Milk Intake and Stroke Mortality in the Japan Collaborative Cohort Study-A Bayesian Survival Analysis. Reviewed International journal

    Chaochen Wang, Hiroshi Yatsuya, Yingsong Lin, Tae Sasakabe, Sayo Kawai, Shogo Kikuchi, Hiroyasu Iso, Akiko Tamakoshi

    Nutrients   Vol. 12 ( 9 )   2020.9

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    The aim of this study was to further examine the relationship between milk intake and stroke mortality among the Japanese population. We used data from the Japan Collaborative Cohort (JACC) Study (total number of participants = 110,585, age range: 40-79) to estimate the posterior acceleration factors (AF) as well as the hazard ratios (HR) comparing individuals with different milk intake frequencies against those who never consumed milk at the study baseline. These estimations were computed through a series of Bayesian survival models that employed a Markov Chain Monte Carlo simulation process. In total, 100,000 posterior samples were generated separately through four independent chains after model convergency was confirmed. Posterior probabilites that daily milk consumers had lower hazard or delayed mortality from strokes compared to non-consumers was 99.0% and 78.0% for men and women, respectively. Accordingly, the estimated posterior means of AF and HR for daily milk consumers were 0.88 (95% Credible Interval, CrI: 0.81, 0.96) and 0.80 (95% CrI: 0.69, 0.93) for men and 0.97 (95% CrI: 0.88, 1.10) and 0.95 (95% CrI: 0.80, 1.17) for women. In conclusion, data from the JACC study provided strong evidence that daily milk intake among Japanese men was associated with delayed and lower risk of mortality from stroke especially cerebral infarction.

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  45. Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for the incidence of type 2 diabetes mellitus among middle-aged Japanese individuals: Aichi Worker's Cohort Study. Reviewed

    Kayo Kaneko, Hiroshi Yatsuya, Yuanying Li, Mayu Uemura, Chifa Chiang, Yoshihisa Hirakawa, Atsuhiko Ota, Koji Tamakoshi, Atsuko Aoyama

    Journal of diabetes investigation   Vol. 11 ( 5 ) page: 1163 - 1169   2020.9

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    AIMS/INTRODUCTION: The Japanese government started a nationwide screening program for metabolic syndrome (MetS) to prevent cardiovascular diseases and diabetes in 2008. Although impaired fasting glucose (IFG) is a strong predictor for type 2 diabetes mellitus, the program does not follow up IFG in non-MetS individuals. This study aimed to examine the risk and the population attributable fraction (PAF) of MetS and IFG for incidence of type 2 diabetes mellitus. MATERIALS AND METHODS: Japanese workers (3,417 men and 714 women) aged 40-64 years without a history of diabetes were prospectively followed. MetS was defined as either abdominal obesity plus two or more metabolic risk factors, or being overweight in the case of normal waist circumference plus three or more metabolic risk factors. IFG was defined as fasting blood glucose 100-125 mg/dL. RESULTS: During a mean 6.3 years, 240 type 2 diabetes mellitus cases were identified. Compared with those without MetS and IFG, the multivariable-adjusted hazard ratios (95% confidence interval) of non-MetS individuals with IFG, MetS individuals without IFG and MetS individuals with IFG for type 2 diabetes mellitus were 4.9 (3.4-7.1), 2.4 (1.6-3.5) and 8.3 (5.9-11.5), respectively. The corresponding PAFs for type 2 diabetes mellitus incidence were 15.6, 9.1 and 29.7%, respectively. CONCLUSIONS: IFG represented a higher risk and PAF than MetS for type 2 diabetes mellitus incidence in middle-aged Japanese individuals. The coexistence of MetS and IFG showed the highest risk and PAF for type 2 diabetes mellitus incidence. The current Japanese MetS screening program should be reconsidered to follow up non-MetS individuals with IFG.

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  46. Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17 Reviewed International coauthorship International journal

    Deshpande Aniruddha, Miller-Petrie Molly K., Lindstedt Paulina A., Baumann Mathew M., Johnson Kimberly B., Blacker Brigette F., Abbastabar Hedayat, Abd-Allah Foad, Abdelalim Ahmed, Abdollahpour Ibrahim, Abegaz Kedir Hussein, Abejie Ayenew Negesse, Abreu Lucas Guimaraes, Abrigo Michael R. M., Abualhasan Ahmed, Accrombessi Manfred Mario Kokou, Adamu Abdu A., Adebayo Oladimeji M., Adedeji Isaac Akinkunmi, Adedoyin Rufus Adesoji, Adekanmbi Victor, Adetokunboh Olatunji O., Adhikari Tara Ballav, Afarideh Mohsen, Agudelo-Botero Marcela, Ahmadi Mehdi, Ahmadi Keivan, Ahmed Muktar Beshir, Ahmed Anwar E., Akalu Temesgen Yihunie, Akanda Ali S., Alahdab Fares, Al-Aly Ziyad, Alam Samiah, Alam Noore, Alamene Genet Melak, Alanzi Turki M., Albright James, Albujeer Ammar, Alcalde-Rabanal Jacqueline Elizabeth, Alebel Animut, Alemu Zewdie Aderaw, Ali Muhammad, Alijanzadeh Mehran, Alipour Vahid, Aljunid Syed Mohamed, Almasi Ali, Almasi-Hashiani Amir, Al-Mekhlafi Hesham M., Altirkawi Khalid A., Alvis-Guzman Nelson, Alvis-Zakzuk Nelson J., Amini Saeed, Amit Arianna Maever L., Amul Gianna Gayle Herrera, Andrei Catalina Liliana, Anjomshoa Mina, Ansariadi Ansariadi, Antonio Carl Abelardo T., Antony Benny, Antriyandarti Ernoiz, Arabloo Jalal, Aref Hany Mohamed Amin, Aremu Olatunde, Armoon Bahram, Arora Amit, Aryal Krishna K., Arzani Afsaneh, Asadi-Aliabadi Mehran, Asmelash Daniel, Atalay Hagos Tasew, Athari Seyyede Masoume, Athari Seyyed Shamsadin, Atre Sachin R., Ausloos Marcel, Awasthi Shally, Awoke Nefsu, Quintanilla Beatriz Paulina Ayala, Ayano Getinet, Ayanore Martin Amogre, Aynalem Yared Asmare, Azari Samad, Azman Andrew S., Babaee Ebrahim, Badawi Alaa, Bagherzadeh Mojtaba, Bakkannavar Shankar M., Balakrishnan Senthilkumar, Banach Maciej, Banoub Joseph Adel Mattar, Barac Aleksandra, Barboza Miguel A., Barnighausen Till Winfried, Basu Sanjay, Vo Dinh Bay, Bayati Mohsen, Bedi Neeraj, Beheshti Mahya, Behzadifar Meysam, Behzadifar Masoud, Ramirez Diana Fernanda Bejarano, Bell Michelle L., Bennett Derrick A., Benzian Habib, Berbada Dessalegn Ajema, Bernstein Robert S., Bhat Anusha Ganapati, Bhattacharyya Krittika, Bhaumik Soumyadeep, Bhutta Zulfiqar A., Bijani Ali, Bikbov Boris, Bin Sayeed Muhammad Shahdaat, Biswas Raaj Kishore, Bohlouli Somayeh, Boufous Soufiane, Brady Oliver J., Briko Andrey Nikolaevich, Briko Nikolay Ivanovich, Britton Gabrielle B., Brown Alexandria, Nagaraja Sharath Burugina, Butt Zahid A., Camera Luis Alberto, Campos-Nonato Ismael R., Rincon Julio Cesar Campuzano, Cano Jorge, Car Josip, Cardenas Rosario, Carvalho Felix, Castaneda-Orjuela Carlos A., Castro Franz, Cerin Ester, Chalise Binaya, Chattu Vijay Kumar, Chin Ken Lee, Christopher Devasahayam J., Chu Dinh-Toi, Cormier Natalie Maria, Costa Vera Marisa, Cromwell Elizabeth A., Dadi Abel Fekadu Fekadu, Dahiru Tukur, Dahlawi Saad M. A., Dandona Rakhi, Dandona Lalit, Dang Anh Kim, Daoud Farah, Darwesh Aso Mohammad, Darwish Amira Hamed, Daryani Ahmad, Das Jai K., Das Gupta Rajat, Dash Aditya Prasad, Davila-Cervantes Claudio Alberto, Weaver Nicole Davis, De la Hoz Fernando Pio, De Neve Jan-Walter, Demissie Dereje Bayissa, Demoz Gebre Teklemariam, Denova-Gutierrez Edgar, Deribe Kebede, Desalew Assefa, Dharmaratne Samath Dhamminda, Dhillon Preeti, Dhimal Meghnath, Dhungana Govinda Prasad, Diaz Daniel, Dipeolu Isaac Oluwafemi, Hoa Thi, Dolecek Christiane, Doyle Kerrie E., Dubljanin Eleonora, Duraes Andre Rodrigues, Edinur Hisham Atan, Effiong Andem, Eftekhari Aziz, El Nahas Nevine, Zaki Maysaa El Sayed, El Tantawi Maha, Elhabashy Hala Rashad, El-Jaafary Shaimaa I, El-Khatib Ziad, Elkout Hajer, Elsharkawy Aisha, Enany Shymaa, Endalew Daniel Adane, Eshrati Babak, Eskandarieh Sharareh, Etemadi Arash, Ezekannagha Oluchi, Faraon Emerito Jose A., Fareed Mohammad, Faro Andre, Farzadfar Farshad, Fasil Alebachew Fasil, Fazlzadeh Mehdi, Feigin Valery L., Fekadu Wubalem, Fentahun Netsanet, Fereshtehnejad Seyed-Mohammad, Fernandes Eduarda, Filip Irina, Fischer Florian, Flohr Carsten, Foigt Nataliya A., Folayan Morenike Oluwatoyin, Foroutan Masoud, Franklin Richard Charles, Frostad Joseph Jon, Fukumoto Takeshi, Gad Mohamed M., Garcia Gregory M., Gatotoh Augustine Mwangi, Gayesa Reta Tsegaye, Gebremedhin Ketema Bizuwork, Geramo Yilma Chisha Dea, Gesesew Hailay Abrha, Gezae Kebede Embaye, Ghashghaee Ahmad, Sherbaf Farzaneh Ghazi, Gill Tiffany K., Gill Paramjit Singh, Ginindza Themba G., Girmay Alem, Gizaw Zemichael, Goodridge Amador, Gopalani Sameer Vali, Goulart Barbara Niegia Garcia, Goulart Alessandra C., Grada Ayman, Green Manfred S., Gubari Mohammed Ibrahim Mohialdeen, Gugnani Harish Chander, Guido Davide, Guimaraes Rafael Alves, Guo Yuming, Gupta Rajeev, Gupta Rahul, Ha Giang Hai, Haagsma Juanita A., Hafezi-Nejad Nima, Haile Dessalegn H., Haile Michael Tamene, Hall Brian J., Hamidi Samer, Handiso Demelash Woldeyohannes, Haririan Hamidreza, Hariyani Ninuk, Hasaballah Ahmed I, Hasan Mehedi, Hasanzadeh Amir, Hassen Hamid Yimam, Hayelom Desta Haftu, Hegazy Mohamed I, Heibati Behzad, Heidari Behnam, Hendrie Delia, Henok Andualem, Herteliu Claudiu, Heydarpour Fatemeh, de Hidru Hagos Degefa, Hird Thomas R., Chi Linh Hoang, Hollerich Gillian I, Hoogar Praveen, Hossain Naznin, Hosseinzadeh Mehdi, Househ Mowafa, Hu Guoqing, Humayun Ayesha, Hussain Syed Ather, Hussen Mamusha Aman A., Ibitoye Segun Emmanuel, Ilesanmi Olayinka Stephen, Ilic Milena D., Imani-Nasab Mohammad Hasan, Iqbal Usman, Irvani Seyed Sina Naghibi, Islam Sheikh Mohammed Shariful, Ivers Rebecca Q., Iwu Chinwe Juliana, Jahanmehr Nader, Jakovljevic Mihajlo, Jalali Amir, Jayatilleke Achala Upendra, Jenabi Ensiyeh, Jha Ravi Prakash, Jha Vivekanand, Ji John S., Jonas Jost B., Jozwiak Jacek Jerzy, Kabir Ali, Kabir Zubair, Kanchan Tanuj, Karch Andre, Karki Surendra, Kasaeian Amir, Kasahun Gebremicheal Gebreslassie, Kasaye Habtamu Kebebe, Kassa Gebrehiwot G., Kassa Getachew Mullu, Kayode Gbenga A., Kebede Mihiretu M., Keiyoro Peter Njenga, Ketema Daniel Bekele, Khader Yousef Saleh, Khafaie Morteza Abdullatif, Khalid Nauman, Khalilov Rovshan, Khan Ejaz Ahmad, Khan Junaid, Khan Nuruzzaman, Khatab Khaled, Khater Mona M., Khater Amir M., Khayamzadeh Maryam, Khazaei Mohammad, Khosravi Mohammad Hossein, Khubchandani Jagdish, Kiadaliri Ali, Kim Yun Jin, Kimokoti Ruth W., Kisa Sezer, Kisa Adnan, Kochhar Sonali, Kolola Tufa, Komaki Hamidreza, Kosen Soewarta, Koul Parvaiz A., Koyanagi Ai, Krishan Kewal, Defo Barthelemy Kuate, Kugbey Nuworza, Kumar Pushpendra, Kumar G. Anil, Kumar Manasi, Kusuma Dian, La Vecchia Carlo, Lacey Ben, Lal Aparna, Lal Dharmesh Kumar, Lam Hilton, Lami Faris Hasan, Lansingh Van Charles, Lasrado Savita, Lebedev Georgy, Lee Paul H., LeGrand Kate E., Leili Mostafa, Lenjebo Tsegaye Lolaso, Leshargie Cheru Tesema, Levine Aubrey J., Lewycka Sonia, Li Shanshan, Linn Shai, Liu Shiwei, Lopez Jaifred Christian F., Lopukhov Platon D., Abd El Razek Muhammed Magdy, Prasad D. R. Mahadeshwara, Mahasha Phetole Walter, Mahotra Narayan B., Majeed Azeem, Malekzadeh Reza, Malta Deborah Carvalho, Mamun Abdullah A., Manafi Navid, Mansournia Mohammad Ali, Mapoma Chabila Christopher, Martinez Gabriel, Martini Santi, Martins-Melo Francisco Rogerlandio, Mathur Manu Raj, Mayala Benjamin K., Mazidi Mohsen, McAlinden Colm, Meharie Birhanu Geta, Mehndiratta Man Mohan, Nasab Entezar Mehrabi, Mehta Kala M., Mekonnen Teferi, Mekonnen Tefera Chane, Meles Gebrekiros Gebremichael, Meles Hagazi Gebre, Memiah Peter T. N., Memish Ziad A., Mendoza Walter, Menezes Ritesh G., Mereta Seid Tiku, Meretoja Tuomo J., Mestrovic Tomislav, Metekiya Workua Mekonnen, Miazgowski Bartosz, Miller Ted R., Mini G. K., Mirrakhimov Erkin M., Moazen Babak, Mohajer Bahram, Mohammad Yousef, Mohammad Dara K., Mezerji Naser Mohammad Gholi, Mohammadibakhsh Roghayeh, Mohammed Shafiu, Mohammed Jemal Abdu, Mohammed Hassen, Mohebi Farnam, Mokdad Ali H., Moodley Yoshan, Moradi Masoud, Moradi Ghobad, Moradi-Joo Mohammad, Moraga Paula, Morales Linda, Mosapour Abbas, Mosser Jonathan F., Mouodi Simin, Mousavi Seyyed Meysam, Mozaffor Miliva, Munro Sandra B., Muriithi Moses K., Murray Christopher J. L., Musa Kamarul Imran, Mustafa Ghulam, Muthupandian Saravanan, Naderi Mehdi, Nagarajan Ahamarshan Jayaraman, Naghavi Mohsen, Naik Gurudatta, Nangia Vinay, Nascimento Bruno Ramos, Nazari Javad, Ndwandwe Duduzile Edith, Negoi Ionut, Netsere Henok Biresaw, Ngunjiri Josephine W., Cuong Tat Nguyen, Huong Lan Thi Nguyen, Nguyen QuynhAnh P., Nigatu Solomon Gedlu, Ningrum Dina Nur Anggraini, Nnaji Chukwudi A., Nojomi Marzieh, Norheim Ole F., Noubiap Jean Jacques, Oancea Bogdan, Ogbo Felix Akpojene, Oh In-Hwan, Olagunju Andrew T., Olusanya Jacob Olusegun, Olusanya Bolajoko Olubukunola, Onwujekwe Obinna E., Ortega-Altamirano Doris V, Osarenotor Osayomwanbo, Osei Frank B., Owolabi Mayowa O., Mahesh P. A., Padubidri Jagadish Rao, Pakhale Smita, Pana Adrian, Park Eun-Kee, Patel Sangram Kishor, Pathak Ashish, Patle Ajay, Paulos Kebreab, Pepito Veincent Christian Filipino, Perico Norberto, Pervaiz Aslam, Pescarini Julia Moreira, Pesudovs Konrad, Pham Hai Quang, Pigott David M., Pilgrim Thomas, Pirsaheb Meghdad, Poljak Mario, Pollock Ian, Postma Maarten J., Pourmalek Farshad, Pourshams Akram, Prada Sergio I, Preotescu Liliana, Quintana Hedley, Rabiee Navid, Rabiee Mohammad, Radfar Amir, Rafiei Alireza, Rahim Fakher, Rahimi Siavash, Rahimi-Movaghar Vafa, Rahman Muhammad Aziz, Rahman Mohammad Hifz Ur, Rajati Fatemeh, Ranabhat Chhabi Lal, Rao Puja C., Rasella Davide, Rath Goura Kishor, Rawaf Salman, Rawal Lal, Rawasia Wasiq Faraz, Remuzzi Giuseppe, Renjith Vishnu, Renzaho Andre M. N., Resnikoff Serge, Riahi Seyed Mohammad, Ribeiro Ana Isabel, Rickard Jennifer, Roever Leonardo, Ronfani Luca, Rubagotti Enrico, Rubino Salvatore, Saad Anas M., Sabour Siamak, Sadeghi Ehsan, Moghaddam Sahar Saeedi, Safari Yahya, Sagar Rajesh, Sahraian Mohammad Ali, Sajadi S. Mohammad, Salahshoor Mohammad Reza, Salam Nasir, Saleem Ahsan, Salem Hosni, Salem Marwa Rashad, Salimi Yahya, Salimzadeh Hamideh, Samy Abdallah M., Sanabria Juan, Santos Itamar S., Santric-Milicevic Milena M., Sao Jose Bruno Piassi, Saraswathy Sivan Yegnanarayana Iyer, Sarrafzadegan Nizal, Sartorius Benn, Sathian Brijesh, Sathish Thirunavukkarasu, Satpathy Maheswar, Sawhney Monika, Sayyah Mehdi, Sbarra Alyssa N., Schaeffer Lauren E., Schwebel David C., Senbeta Anbissa Muleta, Senthilkumaran Subramanian, Sepanlou Sadaf G., Servan-Mori Edson, Shafieesabet Azadeh, Shaheen Amira A., Shahid Izza, Shaikh Masood Ali, Shalash Ali S., Shams-Beyranvand Mehran, Shamsi MohammadBagher, Shamsizadeh Morteza, Shannawaz Mohammed, Sharafi Kiomars, Sharma Rajesh, Sheikh Aziz, Shetty B. Suresh Kumar, Shiferaw Wondimeneh Shibabaw, Shigematsu Mika, Shin Jae Il, Shiri Rahman, Shirkoohi Reza, Shivakumar K. M., Si Si, Siabani Soraya, Siddiqi Tariq Jamal, Silva Diego Augusto Santos, Singh Virendra, Singh Narinder Pal, Singh Balbir Bagicha Singh, Singh Jasvinder A., Singh Ambrish, Sinha Dhirendra Narain, Sisay Malede Mequanent, Skiadaresi Eirini, Smith David L., Filho Adauto Martins Soares, Sobhiyeh Mohammad Reza, Sokhan Anton, Soriano Joan B., Sorrie Muluken Bekele, Soyiri Ireneous N., Spurlock Emma Elizabeth, Sreeramareddy Chandrashekhar T., Sudaryanto Agus, Sufiyan Mu'awiyyah Babale, Suleria Hafiz Ansar Rasul, Sykes Bryan L., Tabares-Seisdedos Rafael, Tabuchi Takahiro, Tadesse Degena Bahrey, Tarigan Ingan Ukur, Taye Bineyam, Tefera Yonatal Mesfin, Tehrani-Banihashemi Arash, Tekelemedhin Shishay Wahdey, Tekle Merhawi Gebremedhin, Temsah Mohamad-Hani, Tesfay Berhe Etsay, Tesfay Fisaha Haile, Tessema Zemenu Tadesse, Thankappan Kavumpurathu Raman, ThekkePurakkal Akhil Soman, Thomas Nihal, Thompson Robert L., Thomson Alan J., Topor-Madry Roman, Tovani-Palone Marcos Roberto, Traini Eugenio, Bach Xuan Tran, Khanh Bao Tran, Ullah Irfan, Unnikrishnan Bhaskaran, Usman Muhammad Shariq, Uthman Olalekan A., Uzochukwu Benjamin S. Chudi, Valdez Pascual R., Varughese Santosh, Veisani Yousef, Violante Francesco S., Vollmer Sebastian, Whawariat Feleke Gebremeskel, Waheed Yasir, Wallin Mitchell Taylor, Wang Yuan-Pang, Wang Yafeng, Wangdi Kinley, Weiss Daniel J., Weldesamuel Girmay Teklay, Werkneh Adhena Ayaliew, Westerman Ronny, Wiangkham Taweewat, Wiens Kirsten E., Wijeratne Tissa, Wiysonge Charles Shey, Wolde Haileab Fekadu, Wondafrash Dawit Zewdu, Wonde Tewodros Eshete, Worku Getasew Taddesse, Yadollahpour Ali, Jabbari Seyed Hossein Yahyazadeh, Yamada Tomohide, Yaseri Mehdi, Yatsuya Hiroshi, Yeshaneh Alex, Yilma Mekdes Tigistu, Yip Paul, Yisma Engida, Yonemoto Naohiro, Younis Mustafa Z., Yousof Hebat-Allah Salah A., Yu Chuanhua, Yusefzadeh Hasan, Zadey Siddhesh, Moghadam Telma Zahirian, Zaidi Zoubida, Bin Zaman Sojib, Zamani Mohammad, Zandian Hamed, Zar Heather J., Zerfu Taddese Alemu, Zhang Yunquan, Ziapour Arash, Zodpey Sanjay, Zuniga Yves Miel H., Hay Simon I, Reiner Robert C. Jr.

    LANCET GLOBAL HEALTH   Vol. 8 ( 9 ) page: E1162 - E1185   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

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  47. Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17

    Deshpande A., Miller-Petrie M.K., Lindstedt P.A., Baumann M.M., Johnson K.B., Blacker B.F., Abbastabar H., Abd-Allah F., Abdelalim A., Abdollahpour I., Abegaz K.H., Abejie A.N., Abreu L.G., Abrigo M.R.M., Abualhasan A., Accrombessi M.M.K., Adamu A.A., Adebayo O.M., Adedeji I.A., Adedoyin R.A., Adekanmbi V., Adetokunboh O.O., Adhikari T.B., Afarideh M., Agudelo-Botero M., Ahmadi M., Ahmadi K., Ahmed A.E., Ahmed M.B., Akalu T.Y., Akanda A.S., Alahdab F., Al-Aly Z., Alam N., Alam S., Alamene G.M., Alanzi T.M., Albright J., Albujeer A., Alcalde-Rabanal J.E., Alebel A., Alemu Z.A., Ali M., Alijanzadeh M., Alipour V., Aljunid S.M., Almasi A., Almasi-Hashiani A., Al-Mekhlafi H.M., Altirkawi K.A., Alvis-Guzman N., Alvis-Zakzuk N.J., Amini S., Amit A.M.L., Amul G.G.H., Andrei C.L., Anjomshoa M., Ansariadi A., Antonio C.A.T., Antony B., Antriyandarti E., Arabloo J., Aref H.M.A., Aremu O., Armoon B., Arora A., Aryal K.K., Arzani A., Asadi-Aliabadi M., Asmelash D., Atalay H.T., Athari S.S., Athari S.M., Atre S.R., Ausloos M., Awasthi S., Awoke N., Quintanilla B.P.A., Ayano G., Ayanore M.A., Aynalem Y.A., Azari S., Azman A.S., Babaee E., Badawi A., Bagherzadeh M., Bakkannavar S.M., Balakrishnan S., Banach M., Banoub J.A.M., Barac A., Barboza M.A., Bärnighausen T.W., Basu S., Bay V.D., Bayati M., Bedi N., Beheshti M., Behzadifar M., Behzadifar M.

    The Lancet Global Health   Vol. 8 ( 9 ) page: e1162 - e1185   2020.9

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    Language:Japanese   Publisher:The Lancet Global Health  

    Background: Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities. Methods: We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs. Findings: Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40·0% (95% uncertainty interval [UI] 39·4–40·7) to 50·3% (50·0–50·5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46·3% (95% UI 46·1–46·5) in 2017, compared with 28·7% (28·5–29·0) in 2000. Although some units improved access to the safest drinking water or sanitation facilities since 2000, a large absolute number of people continued to not have access in several units with high access to such facilities (>80%) in 2017. More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88·6% (95% UI 87·2–89·7) access overall. Many units were able to transition from the least safe facilities in 2000 to safe facilities by 2017; for units in which populations primarily practised open defecation in 2000, 686 (95% UI 664–711) of the 1830 (1797–1863) units transitioned to the use of improved sanitation. Geographical disparities in access to improved water across units decreased in 76·1% (95% UI 71·6–80·7) of countries from 2000 to 2017, and in 53·9% (50·6–59·6) of countries for access to improved sanitation, but remained evident subnationally in most countries in 2017. Interpretation: Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation. Funding: Bill & Melinda Gates Foundation.

    DOI: 10.1016/S2214-109X(20)30278-3

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  48. Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17

    Aniruddha Deshpande, Molly K. Miller-Petrie, Paulina A. Lindstedt, Mathew M. Baumann, Kimberly B. Johnson, Brigette F. Blacker, Hedayat Abbastabar, Foad Abd-Allah, Ahmed Abdelalim, Ibrahim Abdollahpour, Kedir Hussein Abegaz, Ayenew Negesse Abejie, Lucas Guimaraes Abreu, Michael R. M. Abrigo, Ahmed Abualhasan, Manfred Mario Kokou Accrombessi, Abdu A. Adamu, Oladimeji M. Adebayo, Isaac Akinkunmi Adedeji, Rufus Adesoji Adedoyin, Victor Adekanmbi, Olatunji O. Adetokunboh, Tara Ballav Adhikari, Mohsen Afarideh, Marcela Agudelo-Botero, Mehdi Ahmadi, Keivan Ahmadi, Muktar Beshir Ahmed, Anwar E. Ahmed, Temesgen Yihunie Akalu, Ali S. Akanda, Fares Alahdab, Ziyad Al-Aly, Samiah Alam, Noore Alam, Genet Melak Alamene, Turki M. Alanzi, James Albright, Ammar Albujeer, Jacqueline Elizabeth Alcalde-Rabanal, Animut Alebel, Zewdie Aderaw Alemu, Muhammad Ali, Mehran Alijanzadeh, Vahid Alipour, Syed Mohamed Aljunid, Ali Almasi, Amir Almasi-Hashiani, Hesham M. Al-Mekhlafi, Khalid A. Altirkawi, Nelson Alvis-Guzman, Nelson J. Alvis-Zakzuk, Saeed Amini, Arianna Maever L. Amit, Gianna Gayle Herrera Amul, Catalina Liliana Andrei, Mina Anjomshoa, Ansariadi Ansariadi, Carl Abelardo T. Antonio, Benny Antony, Ernoiz Antriyandarti, Jalal Arabloo, Hany Mohamed Amin Aref, Olatunde Aremu, Bahram Armoon, Amit Arora, Krishna K. Aryal, Afsaneh Arzani, Mehran Asadi-Aliabadi, Daniel Asmelash, Hagos Tasew Atalay, Seyyede Masoume Athari, Seyyed Shamsadin Athari, Sachin R. Atre, Marcel Ausloos, Shally Awasthi, Nefsu Awoke, Beatriz Paulina Ayala Quintanilla, Getinet Ayano, Martin Amogre Ayanore, Yared Asmare Aynalem, Samad Azari, Andrew S. Azman, Ebrahim Babaee, Alaa Badawi, Mojtaba Bagherzadeh, Shankar M. Bakkannavar, Senthilkumar Balakrishnan, Maciej Banach, Joseph Adel Mattar Banoub, Aleksandra Barac, Miguel A. Barboza, Till Winfried Barnighausen, Sanjay Basu, Vo Dinh Bay, Mohsen Bayati, Neeraj Bedi, Mahya Beheshti, Meysam Behzadifar, Masoud Behzadifar, Diana Fernanda Bejarano Ramirez, Michelle L. Bell, Derrick A. Bennett, Habib Benzian, Dessalegn Ajema Berbada, Robert S. Bernstein, Anusha Ganapati Bhat, Krittika Bhattacharyya, Soumyadeep Bhaumik, Zulfiqar A. Bhutta, Ali Bijani, Boris Bikbov, Muhammad Shahdaat Bin Sayeed, Raaj Kishore Biswas, Somayeh Bohlouli, Soufiane Boufous, Oliver J. Brady, Andrey Nikolaevich Briko, Nikolay Ivanovich Briko, Gabrielle B. Britton, Alexandria Brown, Sharath Burugina Nagaraja, Zahid A. Butt, Luis Alberto Camera, Ismael R. Campos-Nonato, Julio Cesar Campuzano Rincon, Jorge Cano, Josip Car, Rosario Cardenas, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Ester Cerin, Binaya Chalise, Vijay Kumar Chattu, Ken Lee Chin, Devasahayam J. Christopher, Dinh-Toi Chu, Natalie Maria Cormier, Vera Marisa Costa, Elizabeth A. Cromwell, Abel Fekadu Fekadu Dadi, Tukur Dahiru, Saad M. A. Dahlawi, Rakhi Dandona, Lalit Dandona, Anh Kim Dang, Farah Daoud, Aso Mohammad Darwesh, Amira Hamed Darwish, Ahmad Daryani, Jai K. Das, Rajat Das Gupta, Aditya Prasad Dash, Claudio Alberto Davila-Cervantes, Nicole Davis Weaver, Fernando Pio De la Hoz, Jan-Walter De Neve, Dereje Bayissa Demissie, Gebre Teklemariam Demoz, Edgar Denova-Gutierrez, Kebede Deribe, Assefa Desalew, Samath Dhamminda Dharmaratne, Preeti Dhillon, Meghnath Dhimal, Govinda Prasad Dhungana, Daniel Diaz, Isaac Oluwafemi Dipeolu, Hoa Thi, Christiane Dolecek, Kerrie E. Doyle, Eleonora Dubljanin, Andre Rodrigues Duraes, Hisham Atan Edinur, Andem Effiong, Aziz Eftekhari, Nevine El Nahas, Maysaa El Sayed Zaki, Maha El Tantawi, Hala Rashad Elhabashy, Shaimaa El-Jaafary, Ziad El-Khatib, Hajer Elkout, Aisha Elsharkawy, Shymaa Enany, Daniel Adane Endalew, Babak Eshrati, Sharareh Eskandarieh, Arash Etemadi, Oluchi Ezekannagha, Emerito Jose A. Faraon, Mohammad Fareed, Andre Faro, Farshad Farzadfar, Alebachew Fasil Fasil, Mehdi Fazlzadeh, Valery L. Feigin, Wubalem Fekadu, Netsanet Fentahun, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Irina Filip, Florian Fischer, Carsten Flohr, Nataliya A. Foigt, Morenike Oluwatoyin Folayan, Masoud Foroutan, Richard Charles Franklin, Joseph Jon Frostad, Takeshi Fukumoto, Mohamed M. Gad, Gregory M. Garcia, Augustine Mwangi Gatotoh, Reta Tsegaye Gayesa, Ketema Bizuwork Gebremedhin, Yilma Chisha Dea Geramo, Hailay Abrha Gesesew, Kebede Embaye Gezae, Ahmad Ghashghaee, Farzaneh Ghazi Sherbaf, Tiffany K. Gill, Paramjit Singh Gill, Themba G. Ginindza, Alem Girmay, Zemichael Gizaw, Amador Goodridge, Sameer Vali Gopalani, Barbara Niegia Garcia Goulart, Alessandra C. Goulart, Ayman Grada, Manfred S. Green, Mohammed Ibrahim Mohialdeen Gubari, Harish Chander Gugnani, Davide Guido, Rafael Alves Guimaraes, Yuming Guo, Rajeev Gupta, Rahul Gupta, Giang Hai Ha, Juanita A. Haagsma, Nima Hafezi-Nejad, Dessalegn H. Haile, Michael Tamene Haile, Brian J. Hall, Samer Hamidi, Demelash Woldeyohannes Handiso, Hamidreza Haririan, Ninuk Hariyani, Ahmed Hasaballah, Mehedi Hasan, Amir Hasanzadeh, Hamid Yimam Hassen, Desta Haftu Hayelom, Mohamed Hegazy, Behzad Heibati, Behnam Heidari, Delia Hendrie, Andualem Henok, Claudiu Herteliu, Fatemeh Heydarpour, Hagos Degefa de Hidru, Thomas R. Hird, Chi Linh Hoang, Gillian Hollerich, Praveen Hoogar, Naznin Hossain, Mehdi Hosseinzadeh, Mowafa Househ, Guoqing Hu, Ayesha Humayun, Syed Ather Hussain, Mamusha Aman A. Hussen, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Milena D. Ilic, Mohammad Hasan Imani-Nasab, Usman Iqbal, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Rebecca Q. Ivers, Chinwe Juliana Iwu, Nader Jahanmehr, Mihajlo Jakovljevic, Amir Jalali, Achala Upendra Jayatilleke, Ensiyeh Jenabi, Ravi Prakash Jha, Vivekanand Jha, John S. Ji, Jost B. Jonas, Jacek Jerzy Jozwiak, Ali Kabir, Zubair Kabir, Tanuj Kanchan, Andre Karch, Surendra Karki, Amir Kasaeian, Gebremicheal Gebreslassie Kasahun, Habtamu Kebebe Kasaye, Gebrehiwot G. Kassa, Getachew Mullu Kassa, Gbenga A. Kayode, Mihiretu M. Kebede, Peter Njenga Keiyoro, Daniel Bekele Ketema, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Nauman Khalid, Rovshan Khalilov, Ejaz Ahmad Khan, Junaid Khan, Nuruzzaman Khan, Khaled Khatab, Mona M. Khater, Amir M. Khater, Maryam Khayamzadeh, Mohammad Khazaei, Mohammad Hossein Khosravi, Jagdish Khubchandani, Ali Kiadaliri, Yun Jin Kim, Ruth W. Kimokoti, Sezer Kisa, Adnan Kisa, Sonali Kochhar, Tufa Kolola, Hamidreza Komaki, Soewarta Kosen, Parvaiz A. Koul, Ai Koyanagi, Kewal Krishan, Barthelemy Kuate Defo, Nuworza Kugbey, Pushpendra Kumar, G. Anil Kumar, Manasi Kumar, Dian Kusuma, Carlo La Vecchia, Ben Lacey, Aparna Lal, Dharmesh Kumar Lal, Hilton Lam, Faris Hasan Lami, Van Charles Lansingh, Savita Lasrado, Georgy Lebedev, Paul H. Lee, Kate E. LeGrand, Mostafa Leili, Tsegaye Lolaso Lenjebo, Cheru Tesema Leshargie, Aubrey J. Levine, Sonia Lewycka, Shanshan Li, Shai Linn, Shiwei Liu, Jaifred Christian F. Lopez, Platon D. Lopukhov, Muhammed Magdy Abd El Razek, D. R. Mahadeshwara Prasad, Phetole Walter Mahasha, Narayan B. Mahotra, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Abdullah A. Mamun, Navid Manafi, Mohammad Ali Mansournia, Chabila Christopher Mapoma, Gabriel Martinez, Santi Martini, Francisco Rogerlandio Martins-Melo, Manu Raj Mathur, Benjamin K. Mayala, Mohsen Mazidi, Colm McAlinden, Birhanu Geta Meharie, Man Mohan Mehndiratta, Entezar Mehrabi Nasab, Kala M. Mehta, Teferi Mekonnen, Tefera Chane Mekonnen, Gebrekiros Gebremichael Meles, Hagazi Gebre Meles, Peter T. N. Memiah, Ziad A. Memish, Walter Mendoza, Ritesh G. Menezes, Seid Tiku Mereta, Tuomo J. Meretoja, Tomislav Mestrovic, Workua Mekonnen Metekiya, Bartosz Miazgowski, Ted R. Miller, G. K. Mini, Erkin M. Mirrakhimov, Babak Moazen, Bahram Mohajer, Yousef Mohammad, Dara K. Mohammad, Naser Mohammad Gholi Mezerji, Roghayeh Mohammadibakhsh, Shafiu Mohammed, Jemal Abdu Mohammed, Hassen Mohammed, Farnam Mohebi, Ali H. Mokdad, Yoshan Moodley, Masoud Moradi, Ghobad Moradi, Mohammad Moradi-Joo, Paula Moraga, Linda Morales, Abbas Mosapour, Jonathan F. Mosser, Simin Mouodi, Seyyed Meysam Mousavi, Miliva Mozaffor, Sandra B. Munro, Moses K. Muriithi, Christopher J. L. Murray, Kamarul Imran Musa, Ghulam Mustafa, Saravanan Muthupandian, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Mohsen Naghavi, Gurudatta Naik, Vinay Nangia, Bruno Ramos Nascimento, Javad Nazari, Duduzile Edith Ndwandwe, Ionut Negoi, Henok Biresaw Netsere, Josephine W. Ngunjiri, Cuong Tat Nguyen, Huong Lan Thi Nguyen, QuynhAnh P. Nguyen, Solomon Gedlu Nigatu, Dina Nur Anggraini Ningrum, Chukwudi A. Nnaji, Marzieh Nojomi, Ole F. Norheim, Jean Jacques Noubiap, Bogdan Oancea, Felix Akpojene Ogbo, In-Hwan Oh, Andrew T. Olagunju, Jacob Olusegun Olusanya, Bolajoko Olubukunola Olusanya, Obinna E. Onwujekwe, Doris Ortega-Altamirano, Osayomwanbo Osarenotor, Frank B. Osei, Mayowa O. Owolabi, P. A. Mahesh, Jagadish Rao Padubidri, Smita Pakhale, Adrian Pana, Eun-Kee Park, Sangram Kishor Patel, Ashish Pathak, Ajay Patle, Kebreab Paulos, Veincent Christian Filipino Pepito, Norberto Perico, Aslam Pervaiz, Julia Moreira Pescarini, Konrad Pesudovs, Hai Quang Pham, David M. Pigott, Thomas Pilgrim, Meghdad Pirsaheb, Mario Poljak, Ian Pollock, Maarten J. Postma, Farshad Pourmalek, Akram Pourshams, Sergio Prada, Liliana Preotescu, Hedley Quintana, Navid Rabiee, Mohammad Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Siavash Rahimi, Vafa Rahimi-Movaghar, Muhammad Aziz Rahman, Mohammad Hifz Ur Rahman, Fatemeh Rajati, Chhabi Lal Ranabhat, Puja C. Rao, Davide Rasella, Goura Kishor Rath, Salman Rawaf, Lal Rawal, Wasiq Faraz Rawasia, Giuseppe Remuzzi, Vishnu Renjith, Andre M. N. Renzaho, Serge Resnikoff, Seyed Mohammad Riahi, Ana Isabel Ribeiro, Jennifer Rickard, Leonardo Roever, Luca Ronfani, Enrico Rubagotti, Salvatore Rubino, Anas M. Saad, Siamak Sabour, Ehsan Sadeghi, Sahar Saeedi Moghaddam, Yahya Safari, Rajesh Sagar, Mohammad Ali Sahraian, S. Mohammad Sajadi, Mohammad Reza Salahshoor, Nasir Salam, Ahsan Saleem, Hosni Salem, Marwa Rashad Salem, Yahya Salimi, Hamideh Salimzadeh, Abdallah M. Samy, Juan Sanabria, Itamar S. Santos, Milena M. Santric-Milicevic, Bruno Piassi Sao Jose, Sivan Yegnanarayana Iyer Saraswathy, Nizal Sarrafzadegan, Benn Sartorius, Brijesh Sathian, Thirunavukkarasu Sathish, Maheswar Satpathy, Monika Sawhney, Mehdi Sayyah, Alyssa N. Sbarra, Lauren E. Schaeffer, David C. Schwebel, Anbissa Muleta Senbeta, Subramanian Senthilkumaran, Sadaf G. Sepanlou, Edson Servan-Mori, Azadeh Shafieesabet, Amira A. Shaheen, Izza Shahid, Masood Ali Shaikh, Ali S. Shalash, Mehran Shams-Beyranvand, MohammadBagher Shamsi, Morteza Shamsizadeh, Mohammed Shannawaz, Kiomars Sharafi, Rajesh Sharma, Aziz Sheikh, B. Suresh Kumar Shetty, Wondimeneh Shibabaw Shiferaw, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Reza Shirkoohi, K. M. Shivakumar, Si Si, Soraya Siabani, Tariq Jamal Siddiqi, Diego Augusto Santos Silva, Virendra Singh, Narinder Pal Singh, Balbir Bagicha Singh Singh, Jasvinder A. Singh, Ambrish Singh, Dhirendra Narain Sinha, Malede Mequanent Sisay, Eirini Skiadaresi, David L. Smith, Adauto Martins Soares Filho, Mohammad Reza Sobhiyeh, Anton Sokhan, Joan B. Soriano, Muluken Bekele Sorrie, Ireneous N. Soyiri, Emma Elizabeth Spurlock, Chandrashekhar T. Sreeramareddy, Agus Sudaryanto, Mu'awiyyah Babale Sufiyan, Hafiz Ansar Rasul Suleria, Bryan L. Sykes, Rafael Tabares-Seisdedos, Takahiro Tabuchi, Degena Bahrey Tadesse, Ingan Ukur Tarigan, Bineyam Taye, Yonatal Mesfin Tefera, Arash Tehrani-Banihashemi, Shishay Wahdey Tekelemedhin, Merhawi Gebremedhin Tekle, Mohamad-Hani Temsah, Berhe Etsay Tesfay, Fisaha Haile Tesfay, Zemenu Tadesse Tessema, Kavumpurathu Raman Thankappan, Akhil Soman ThekkePurakkal, Nihal Thomas, Robert L. Thompson, Alan J. Thomson, Roman Topor-Madry, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Khanh Bao Tran, Irfan Ullah, Bhaskaran Unnikrishnan, Muhammad Shariq Usman, Olalekan A. Uthman, Benjamin S. Chudi Uzochukwu, Pascual R. Valdez, Santosh Varughese, Yousef Veisani, Francesco S. Violante, Sebastian Vollmer, Feleke Gebremeskel Whawariat, Yasir Waheed, Mitchell Taylor Wallin, Yuan-Pang Wang, Yafeng Wang, Kinley Wangdi, Daniel J. Weiss, Girmay Teklay Weldesamuel, Adhena Ayaliew Werkneh, Ronny Westerman, Taweewat Wiangkham, Kirsten E. Wiens, Tissa Wijeratne, Charles Shey Wiysonge, Haileab Fekadu Wolde, Dawit Zewdu Wondafrash, Tewodros Eshete Wonde, Getasew Taddesse Worku, Ali Yadollahpour, Seyed Hossein Yahyazadeh Jabbari, Tomohide Yamada, Mehdi Yaseri, Hiroshi Yatsuya, Alex Yeshaneh, Mekdes Tigistu Yilma, Paul Yip, Engida Yisma, Naohiro Yonemoto, Mustafa Z. Younis, Hebat-Allah Salah A. Yousof, Chuanhua Yu, Hasan Yusefzadeh, Siddhesh Zadey, Telma Zahirian Moghadam, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Hamed Zandian, Heather J. Zar, Taddese Alemu Zerfu, Yunquan Zhang, Arash Ziapour, Sanjay Zodpey, Yves Miel H. Zuniga, Simon Hay, Robert C. Reiner

    LANCET GLOBAL HEALTH   Vol. 8 ( 9 ) page: E1162 - E1185   2020.9

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    Background Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities.Methods We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs.Findings Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40.0% (95% uncertainty interval [UI] 39.4-40.7) to 50.3% (50.0-50.5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46.3% (95% UI 46.1-46.5) in 2017, compared with 28.7% (28.5-29.0) in 2000. Although some units improved access to the safest drinking water or sanitation facilities since 2000, a large absolute number of people continued to not have access in several units with high access to such facilities (>80%) in 2017. More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88.6% (95% UI 87.2-89.7) access overall. Many units were able to transition from the least safe facilities in 2000 to safe facilities by 2017; for units in which populations primarily practised open defecation in 2000, 686 (95% UI 664-711) of the 1830 (1797-1863) units transitioned to the use of improved sanitation. Geographical disparities in access to improved water across units decreased in 76.1% (95% UI 71.6-80.7) of countries from 2000 to 2017, and in 53.9% (50.6-59.6) of countries for access to improved sanitation, but remained evident subnationally in most countries in 2017.Interpretation Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.

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  49. The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes. Reviewed International journal

    Madoka Matsushita, Akiko Muramoto, Eri Nomura, Yukari Eguchi, Ayako Kato, Yoshiko Sano, Mai Kabayama, Masashi Arakawa, Yuko Oguma, Daisuke Yabe, Masaaki Matsunaga, Hiroshi Yatsuya, Hiroshi Arima, Kazuyo Tsushita

    Nutrition & diabetes   Vol. 10 ( 1 ) page: 33 - 33   2020.8

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    BACKGROUND: The aim of this study was to determine the effectiveness of the Smart Life Stay (SLS) program, which is an experience-oriented stayover program, in combination with health tourism and mandatory health guidance on glucose metabolism after 2 years. METHODS: The participants of the SLS program (n = 792) were recruited from a database of 23 medical insurers. They underwent a mandatory health examination termed Specific Health Checkups in 2014. The participants were included if they had diabetes or were at a high risk of diabetes and if they satisfied the following inclusion criteria: (1) body mass index (BMI; kg/m2) > 25, or (2) waist circumference (WC; cm) > 85 for men and > 90 for women, or (3) hemoglobin A1c (HbA1c; %) > 5.6, or (4) fasting plasma glucose (FPG; mg/dl) > 100. Individuals who corresponded to one or more items were included as study participants. The control subjects (n = 3645) were nonparticipants of the program who were selected from the database and met the inclusion criteria. The lifestyle changes and changes in mean BMI, WC, FPG, and HbA1c in both groups from baseline to 2-year follow-up were compared by inverse probability weighting of a propensity score. RESULTS: The percentage of people who exercised regularly increased significantly in the SLS group compared with the control group. In the SLS group, BW, BMI, and WC significantly decreased by 1.75 kg, 0.60 kg/m2, and 1.45 cm, respectively, whereas in the control group, WC, FPG, and HbA1c increased significantly by 0.38 cm, 3.37 mg/dl, and 0.12%, respectively. The comparison between groups revealed that the BW, BMI, WC, FPG, and HbA1c improved significantly in the SLS group. CONCLUSIONS: The SLS program is suggested to help improve glucose metabolism. This program could be a feasible option as a lifestyle intervention program for diabetes.

    DOI: 10.1038/s41387-020-00136-x

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  50. Glycated haemoglobin (HbA1c) as a reliable option for detecting diabetes among the urban poor population in Bangladesh. Reviewed International coauthorship International journal

    Chiang C, Aoyama A, Khalequzzaman M, Choudhury SR, Paul D, Rayna SE, Khan FA, Hirakawa Y, Iso H, Yatsuya H

    European journal of public health   Vol. 30 ( 4 ) page: 839 - 841   2020.8

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    Our previous epidemiological survey targeting urban slum dwellers in Bangladesh showed that the prevalence of diabetes defined by glycated haemoglobin (HbA1c) was higher than the national estimation, and higher in women than men. Subsequently, we conducted the oral glucose tolerance test (OGTT) and found that HbA1c values were consistent with the OGTT findings for detecting diabetes. Our findings indicated that HbA1c ≥6.5% was a rational cut-off, but the optimal HbA1c cut-off for this population might be lower than the internationally recommended threshold. Measuring HbA1c would be a reliable and feasible option for detecting diabetes among underprivileged population in developing countries.

    DOI: 10.1093/eurpub/cky275

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  51. Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17 Reviewed International coauthorship International journal

    Wiens Kirsten E., Lindstedt Paulina A., Blacker Brigette F., Johnson Kimberly B., Baumann Mathew M., Schaeffer Lauren E., Abbastabar Hedayat, Abd-Allah Foad, Abdelalim Ahmed, Abdollahpour Ibrahim, Abegaz Kedir Hussein, Abejie Ayenew Negesse, Abreu Lucas Guimaraes, Abrigo Michael R. M., Abualhasan Ahmed, Accrombessi Manfred Mario Kokou, Acharya Dilaram, Adabi Maryam, Adamu Abdu A., Adebayo Oladimeji M., Adedoyin Rufus Adesoji, Adekanmbi Victor, Adetokunboh Olatunji O., Adhena Beyene Meressa, Afarideh Mohsen, Ahmad Sohail, Ahmadi Keivan, Ahmed Anwar E., Ahmed Muktar Beshir, Ahmed Rushdia, Akalu Temesgen Yihunie, Alahdab Fares, Al-Aly Ziyad, Alam Noore, Alam Samiah, Alamene Genet Melak, Alanzi Turki M., Alcalde-Rabanal Jacqueline Elizabeth, Ali Beriwan Abdulqadir, Alijanzadeh Mehran, Alipour Vahid, Aljunid Syed Mohamed, Almasi Ali, Almasi-Hashiani Amir, Al-Mekhlafi Hesham M., Altirkawi Khalid A., Alvis-Guzman Nelson, Alvis-Zakzuk Nelson J., Amini Saeed, Amit Arianna Maever L., Andrei Catalina Liliana, Anjomshoa Mina, Anoushiravani Amir, Ansari Fereshteh, Antonio Carl Abelardo T., Antony Benny, Antriyandarti Ernoiz, Arabloo Jalal, Aref Hany Mohamed Amin, Aremu Olatunde, Armoon Bahram, Arora Amit, Aryal Krishna K., Arzani Afsaneh, Asadi-Aliabadi Mehran, Atalay Hagos Tasew, Athari Seyyed Shamsadin, Athari Seyyede Masoume, Atre Sachin R., Ausloos Marcel, Awoke Nefsu, Quintanilla Beatriz Paulina Ayala, Ayano Getinet, Ayanore Martin Amogre, Aynalem Yared Asmare, Azari Samad, Azzopardi Peter S., Babaee Ebrahim, Babalola Tesleem Kayode, Badawi Alaa, Bairwa Mohan, Bakkannavar Shankar M., Balakrishnan Senthilkumar, Bali Ayele Geleto, Banach Maciej, Banoub Joseph Adel Mattar, Barac Aleksandra, Barnighausen Till Winfried, Basaleem Huda, Basu Sanjay, Bay Vo Dinh, Bayati Mohsen, Baye Estifanos, Bedi Neeraj, Beheshti Mahya, Behzadifar Masoud, Behzadifar Meysam, Bekele Bayu Begashaw, Belayneh Yaschilal Muche, Bell Michelle L., Bennett Derrick A., Berbada Dessalegn Ajema, Bernstein Robert S., Bhat Anusha Ganapati, Bhattacharyya Krittika, Bhattarai Suraj, Bhaumik Soumyadeep, Bhutta Zulfiqar A., Bijani Ali, Bikbov Boris, Birihane Binyam Minuye, Biswas Raaj Kishore, Bohlouli Somayeh, Bojia Hunduma Amensisa, Boufous Soufiane, Brady Oliver J., Bragazzi Nicola Luigi, Briko Andrey Nikolaevich, Briko Nikolay Ivanovich, Britton Gabrielle B., Nagaraja Sharath Burugina, Busse Reinhard, Butt Zahid A., Camera Luis Alberto, Campos-Nonato Ismael R., Cano Jorge, Car Josip, Cardenas Rosario, Carvalho Felix, Castaneda-Orjuela Carlos A., Castro Franz, Chanie Wagaye Fentahun, Chatterjee Pranab, Chattu Vijay Kumar, Chichiabellu Tesfaye Yitna, Chin Ken Lee, Christopher Devasahayam J., Chu Dinh-Toi, Cormier Natalie Maria, Costa Vera Marisa, Culquichicon Carlos, Daba Matiwos Soboka, Damiani Giovanni, Dandona Lalit, Dandona Rakhi, Dang Anh Kim, Darwesh Aso Mohammad, Darwish Amira Hamed, Daryani Ahmad, Das Jai K., Das Gupta Rajat, Dash Aditya Prasad, Davey Gail, Davila-Cervantes Claudio Alberto, Davis Adrian C., Davitoiu Dragos Virgil, De la Hoz Fernando Pio, Demis Asmamaw Bizuneh, Demissie Dereje Bayissa, Demissie Getu Debalkie, Demoz Gebre Teklemariam, Demoz Gebre Teklemariam, Denova-Gutierrez Edgar, Deribe Kebede, Desalew Assefa, Deshpande Aniruddha, Dharmaratne Samath Dhamminda, Dhillon Preeti, Dhimal Meghnath, Dhungana Govinda Prasad, Diaz Daniel, Dipeolu Isaac Oluwafemi, Djalalinia Shirin, Doyle Kerrie E., Dubljanin Eleonora, Duko Bereket, Duraes Andre Rodrigues, Kalan Mohammad Ebrahimi, Edinur Hisham Atan, Effiong Andem, Eftekhari Aziz, El Nahas Nevine, El Sayed Iman, Zaki Maysaa El Sayed, El Tantawi Maha, Elema Teshome Bekele, Elhabashy Hala Rashad, El-Jaafary Shaimaa I., Elkout Hajer, Elsharkawy Aisha, Elyazar Iqbal R. F., Endalamaw Aklilu, Endalew Daniel Adane, Eskandarieh Sharareh, Esteghamati Alireza, Esteghamati Sadaf, Etemadi Arash, Ezekannagha Oluchi, Fareed Mohammad, Faridnia Roghiyeh, Farzadfar Farshad, Fazlzadeh Mehdi, Feigin Valery L., Fereshtehnejad Seyed-Mohammad, Fernandes Eduarda, Filip Irina, Fischer Florian, Foigt Nataliya A., Folayan Morenike Oluwatoyin, Foroutan Masoud, Franklin Richard Charles, Fukumoto Takeshi, Gad Mohamed M., Gayesa Reta Tsegaye, Gebre Teshome, Gebremedhin Ketema Bizuwork, Gebremeskel Gebreamlak Gebremedhn, Gesesew Hailay Abrha, Gezae Kebede Embaye, Ghadiri Keyghobad, Ghashghaee Ahmad, Ghimire Pramesh Raj, Gill Paramjit Singh, Gill Tiffany K., Ginindza Themba G., Gomes Nelson G. M., Gopalani Sameer Vali, Goulart Alessandra C., Goulart Barbara Niegia Garcia, Grada Ayman, Gubari Mohammed Ibrahim Mohialdeen, Gugnani Harish Chander, Guido Davide, Guimaraes Rafael Alves, Guo Yuming, Gupta Rajeev, Hafezi-Nejad Nima, Haile Dessalegn H., Hailu Gessessew Bugssa, Haj-Mirzaian Arvin, Haj-Mirzaian Arya, Hamadeh Randah R., Hamidi Samer, Handiso Demelash Woldeyohannes, Haririan Hamidreza, Hariyani Ninuk, Hasaballah Ahmed I., Hasan Md Mehedi, Hasanpoor Edris, Hasanzadeh Amir, Hassankhani Hadi, Hassen Hamid Yimam, Hegazy Mohamed I., Heibati Behzad, Heidari Behnam, Hendrie Delia, Henry Nathaniel J., Herteliu Claudiu, Heydarpour Fatemeh, de Hidru Hagos Degefa, Hird Thomas R., Hoang Chi Linh, Rad Enayatollah Homaie, Hoogar Praveen, Hoseini Mohammad, Hossain Naznin, Hosseini Mostafa, Hosseinzadeh Mehdi, Househ Mowafa, Hsairi Mohamed, Hu Guoqing, Hussen Mohammedaman Mama, Ibitoye Segun Emmanuel, Igumbor Ehimario U., Ilesanmi Olayinka Stephen, Ilic Milena D., Imani-Nasab Mohammad Hasan, Iqbal Usman, Irvani Seyed Sina Naghibi, Islam Sheikh Mohammed Shariful, Iwu Chinwe Juliana, Izadi Neda, Jaca Anelisa, Jahanmehr Nader, Jakovljevic Mihajlo, Jalali Amir, Jayatilleke Achala Upendra, Jha Ravi Prakash, Jha Vivekanand, Ji John S., Jonas Jost B., Jozwiak Jacek Jerzy, Kabir Ali, Kabir Zubair, Kahsay Amaha, Kalani Hamed, Kanchan Tanuj, Matin Behzad Karami, Karch Andre, Karim Mohd Anisul, Karki Hamidreza Karimi-Sari Surendra, Kasaeian Amir, Kasahun Gebremicheal Gebreslassie, Kasahun Yawukal Chane, Kasaye Habtamu Kebebe, Kassa Gebrehiwot G., Kassa Getachew Mullu, Kayode Gbenga A., Karyani Ali Kazemi, Kebede Mihiretu M., Keiyoro Peter Njenga, Kelbore Abraham Getachew, Kengne Andre Pascal, Ketema Daniel Bekele, Khader Yousef Saleh, Khafaie Morteza Abdullatif, Khalid Nauman, Khalilov Rovshan, Khan Ejaz Ahmad, Khan Junaid, Khan Md Nuruzzaman, Khan Muhammad Shahzeb, Khatab Khaled, Khater Amir M., Khater Mona M., Khayamzadeh Maryam, Khazaei Mohammad, Khazaei Salman, Khosravi Mohammad Hossein, Khubchandani Jagdish, Kiadaliri Ali, Kim Yun Jin, Kimokoti Ruth W., Kisa Adnan, Kisa Sezer, Kissoon Niranjan, Shivakumar K. M., Kochhar Sonali, Kolola Tufa, Komaki Hamidreza, Kosen Soewarta, Koul Parvaiz A., Koyanagi Ai, Kraemer Moritz U. G., Krishan Kewal, Kugbey Nuworza, Kumar G. Anil, Kumar Manasi, Kumar Pushpendra, Kusuma Vivek Kumar Dian, La Vecchia Carlo, Lacey Ben, Lad Sheetal D., Lal Dharmesh Kumar, Lam Felix, Lami Faris Hasan, Lamichhane Prabhat, Lansingh Van Charles, Lasrado Savita, Laxmaiah Avula, Lee Paul H., LeGrand Kate E., Leili Mostafa, Lenjebo Tsegaye Lolaso, Leshargie Cheru Tesema, Levine Aubrey J., Li Shanshan, Linn Shai, Liu Shiwei, Liu Simin, Lodha Rakesh, Longbottom Joshua, Lopez Jaifred Christian F., Abd El Razek Hassan Magdy, Abd El Razek Muhammed Magdy, Prasad D. R. Mahadeshwara, Mahasha Phetole Walter, Mahotra Narayan B., Majeed Azeem, Malekzadeh Reza, Malta Deborah Carvalho, Mamun Abdullah A., Manafi Navid, Manda Ana Laura, Manohar Narendar Dawani Dawanu, Mansournia Mohammad Ali, Mapoma Chabila Christopher, Maravilla Joemer C., Martinez Gabriel, Martini Santi, Martins-Melo Francisco Rogerlandio, Masaka Anthony, Massenburg Benjamin Ballard, Mathur Manu Raj, Mayala Benjamin K., Mazidi Mohsen, McAlinden Colm, Meharie Birhanu Geta, Mehndiratta Man Mohan, Mehta Kala M., Mekonnen Tefera Chane, Meles Gebrekiros Gebremichael, Memiah Peter T. N., Memish Ziad A., Mendoza Walter, Menezes Ritesh G., Mereta Seid Tiku, Meretoja Tuomo J., Mestrovic Tomislav, Miazgowski Bartosz, Mihretie Kebadnew Mulatu, Miller Ted R., Mini G. K., Mirrakhimov Erkin M., Moazen Babak, Mohajer Bahram, Mohamadi-Bolbanabad Amjad, Mohammad Dara K., Mohammad Karzan Abdulmuhsin, Mohammad Yousef, Mezerji Naser Mohammad Gholi, Mohammadibakhsh Roghayeh, Mohammadifard Noushin, Mohammed Jemal Abdu, Mohammed Shafiu, Mohebi Farnam, Mokdad Ali H., Molokhia Mariam, Monasta Lorenzo, Moodley Yoshan, Moore Catrin E., Moradi Ghobad, Moradi Masoud, Moradi-Joo Mohammad, Moradi-Lakeh Maziar, Moraga Paula, Morales Linda, Velasquez Ilais Moreno, Mosapour Abbas, Mouodi Simin, Mousavi Seyyed Meysam, Mozaffor Miliva, Muchie Kindie Fentahun, Mulaw Getahun Fentaw, Munro Sandra B., Muriithi Moses K., Murray Christoper J. L., Murthy G. V. S., Musa Kamarul Imran, Mustafa Ghulam, Muthupandian Saravanan, Nabhan Ashraf F., Naderi Mehdi, Nagarajan Ahamarshan Jayaraman, Naidoo Kovin S., Naik Gurudatta, Najafi Farid, Nangia Vinay, Nansseu Jobert Richie, Nascimento Bruno Ramos, Nazari Javad, Ndwandwe Duduzile Edith, Negoi Ionut, Netsere Henok Biresaw, Ngunjiri Josephine W., Nguyen Cuong Tat, Nguyen Huong Lan Thi, Nguyen Trang Huyen, Nigatu Dabere, Nigatu Solomon Gedlu, Ningrum Dina Nur Anggraini, Nnaji Chukwudi A., Nojomi Marzieh, Nong Vuong Minh, Norheim Ole F., Noubiap Jean Jacques, Motlagh Soraya Nouraei, Oancea Bogdan, Ogah Okechukwu Samuel, Ogbo Felix Akpojene, Oh In-Hwan, Olagunju Andrew T., Olagunju Tinuke O., Olusanya Bolajoko Olubukunola, Olusanya Jacob Olusegun, Onwujekwe Obinna E., Oren Eyal, Ortega-Altamirano Doris V., Osarenotor Osayomwanbo, Osei Frank B., Owolabi Mayowa O., Mahesh P. A., Padubidri Jagadish Rao, Pakhale Smita, Patel Sangram Kishor, Paternina-Caicedo Angel J., Pathak Ashish, Patton George C., Paudel Deepak, Paulos Kebreab, Pepito Veincent Christian Filipino, Pereira Alexandre, Perico Norberto, Pervaiz Aslam, Pescarini Julia Moreira, Piroozi Bakhtiar, Pirsaheb Meghdad, Postma Maarten J., Pourjafar Hadi, Pourmalek Farshad, Pourshams Akram, Poustchi Hossein, Prada Sergio I., Prasad Narayan, Preotescu Liliana, Quintana Hedley, Rabiee Navid, Radfar Amir, Rafiei Alireza, Rahim Fakher, Rahimi-Movaghar Afarin, Rahimi-Movaghar Vafa, Rahman Mohammad Hifz Ur, Rahman Muhammad Aziz, Rahman Shafiur, Rajati Fatemeh, Rana Saleem Muhammad, Ranabhat Chhabi Lal, Rasella Davide, Rawaf David Laith, Rawaf Salman, Rawal Lal, Rawasia Wasiq Faraz, Renjith Vishnu, Renzaho Andre M. N., Resnikoff Serge, Reta Melese Abate, Rezaei Negar, Rezai Mohammad Sadegh, Riahi Seyed Mohammad, Ribeiro Ana Isabel, Rickard Jennifer, Rios-Blancas Maria, Roever Leonardo, Ronfani Luca, Roro Elias Merdassa, Ross Jennifer M., Rubagotti Enrico, Rubino Salvatore, Saad Anas M., Sabde Yogesh Damodar, Sabour Siamak, Sadeghi Ehsan, Safari Yahya, Safari-Faramani Roya, Sagar Rajesh, Sahebkar Amirhossein, Sahraian Mohammad Ali, Sajadi S. Mohammad, Salahshoor Mohammad Reza, Salam Nasir, Salamati Payman, Salem Hosni, Salem Marwa Rashad, Salimi Yahya, Salimzadeh Hamideh, Samy Abdallah M., Sanabria Juan, Santric-Milicevic Milena M., Jose Bruno Piassi Sao, Saraswathy Sivan Yegnanarayana Iyer, Sarkar Kaushik, Sarker Abdur Razzaque, Sarrafzadegan Nizal, Sartorius Benn, Sathian Brijesh, Sathish Thirunavukkarasu, Sawhney Monika, Saxena Sonia, Schwebel David C., Senbeta Anbissa Muleta, Senthilkumaran Subramanian, Sepanlou Sadaf G., Servan-Mori Edson, Shabaninejad Hosein, Shafieesabet Azadeh, Shaikh Masood Ali, Shalash Ali S., Shallo Seifadin Ahmed, Shams-Beyranvand Mehran, Shamsi MohammadBagher, Shamsizadeh Morteza, Shannawaz Mohammed, Sharafi Kiomars, Sharifi Hamid, Shehata Hatem Samir, Sheikh Aziz, Shetty B. Suresh Kumar, Shibuya Kenji, Shiferaw Wondimeneh Shibabaw, Shifti Desalegn Markos, Shigematsu Mika, Il Shin Jae, Shiri Rahman, Shirkoohi Reza, Siabani Soraya, Siddiqi Tariq Jamal, Silva Diego Augusto Santos, Singh Ambrish, Singh Jasvinder A., Singh Narinder Pal, Singh Virendra, Sisay Malede Mequanent, Skiadaresi Eirini, Sobhiyeh Mohammad Reza, Sokhan Anton, Soltani Shahin, Somayaji Ranjani, Soofi Moslem, Sorrie Muluken Bekele, Soyiri Ireneous N., Sreeramareddy Chandrashekhar T., Sudaryanto Agus, Sufiyan Mu'awiyyah Babale, Suleria Hafiz Ansar Rasul, Sultana Marufa, Sunguya Bruno Fokas, Sykes Bryan L., Tabares-Seisdedos Rafael, Tabuchi Takahiro, Tadesse Degena Bahrey, Tarigan Ingan Ukur, Tasew Aberash Abay, Tefera Yonatal Mesfin, Tekle Merhawi Gebremedhin, Temsah Mohamad-Hani, Tesfay Berhe Etsay, Tesfay Fisaha Haile, Tessema Belay, Tessema Zemenu Tadesse, Thankappan Kavumpurathu Raman, Thomas Nihal, Toma Alemayehu, Topor-Madry Roman, Tovani-Palone Marcos Roberto, Traini Eugenio, Tran Bach Xuan, Tran Khanh Bao, Ullah Irfan, Unnikrishnan Bhaskaran, Usman Muhammad Shariq, Uzochukwu Benjamin S. Chudi, Valdez Pascual R., Varughese Santosh, Violante Francesco S., Vollmer Sebastian, Hawariat Feleke Gebremeskel W., Waheed Yasir, Wallin Mitchell Taylor, Wang Yafeng, Wang Yuan-Pang, Weaver Marcia, Weji Bedilu Girma, Weldesamuel Girmay Teklay, Welgan Catherine A., Werdecker Andrea, Westerman Ronny, Wiangkham Taweewat, Wiysonge Charles Shey, Wolde Haileab Fekadu, Wondafrash Dawit Zewdu, Wonde Tewodros Eshete, Worku Getasew Taddesse, Wu Ai-Min, Xu Gelin, Yadollahpour Ali, Jabbari Seyed Hossein Yahyazadeh, Yamada Tomohide, Yatsuya Hiroshi, Yeshaneh Alex, Yilgwan Christopher Sabo, Yilma Mekdes Tigistu, Yip Paul, Yisma Engida, Yonemoto Naohiro, Yoon Seok-Jun, Younis Mustafa Z., Yousefifard Mahmoud, Yousof Hebat-Allah Salah A., Yu Chuanhua, Yusefzadeh Hasan, Zadey Siddhesh, Zaidi Zoubida, Bin Zaman Sojib, Zamani Mohammad, Zandian Hamed, Zepro Nejimu Biza, Zerfu Taddese Alemu, Zhang Yunquan, Zhao Xiu-Ju George, Ziapour Arash, Zodpey Sanjay, Zuniga Yves Miel H., Hay Simon I., Reiner Robert C. Jr.

    LANCET GLOBAL HEALTH   Vol. 8 ( 8 ) page: 1038 - 1060   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  52. Risk Factors of Infectious Complications After Endobronchial Ultrasound-Guided Transbronchial Biopsy. Reviewed International journal

    Tomohide Souma, Tomoyuki Minezawa, Hiroshi Yatsuya, Takuya Okamura, Kumiko Yamatsuta, Sayako Morikawa, Tomoya Horiguchi, Shingo Maeda, Yasuhiro Goto, Masamichi Hayashi, Sumito Isogai, Naoki Yamamoto, Masashi Kondo, Kazuyoshi Imaizumi

    Chest   Vol. 158 ( 2 ) page: 797 - 807   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Infectious complications after endobronchial ultrasound-guided transbronchial biopsy with a guide sheath (EBUS-GS-TBB) are serious in that they may delay or change scheduled subsequent therapy. The aim of this study was to identify risk factors for infection after EBUS-GS-TBB. RESEARCH QUESTION: What are the risk factors for infection after EBUS-GS-TBB? STUDY DESIGN AND METHODS: We retrospectively reviewed the medical records of 1,045 consecutive patients who had undergone EBUS-GS-TBB for peripheral lung lesions between January 2013 and December 2017 at Fujita Health University Hospital. We evaluated the following risk factors for infectious complications after EBUS-GS-TBB: relevant patient characteristics (age and comorbidities), lesion size, CT scan features of target lesion (intratumoral low-density areas [LDAs] and cavitation), stenosis of responsible bronchus observed by bronchoscopy, and laboratory data before EBUS-GS-TBB (WBC count and C-reactive protein concentration). RESULTS: Forty-seven of the study patients developed infectious complications (24 with pneumonia, 14 with intratumoral infection, three with lung abscess, three with pleuritis, and three with empyema), among whom the complication caused a delay in cancer treatment in 13 patients, cancellation of cancer treatment in seven patients, and death in three patients. Multivariate analysis showed that cavitation (P = .007), intratumoral LDAs (P < .001), and stenosis of responsible bronchus observed by bronchoscopy (P < .001) were significantly associated with infectious complications after EBUS-GS-TBB. Prophylactic antibiotics had been administered to 13 patients in the infection group. Propensity matched analysis could not show significant benefit of prophylactic antibiotics in preventing post-EBUS-GS-TBB infections. INTERPRETATION: Cavitation, LDAs for CT scan features of target lesions, and stenosis of responsible bronchus observed by bronchoscopy are risk factors of post-EBUS-GS-TBB infection. In the cohort, prophylactic antibiotics failed to prevent infectious complications.

    DOI: 10.1016/j.chest.2020.02.025

    PubMed

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  53. Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17

    Wiens K.E., Lindstedt P.A., Blacker B.F., Johnson K.B., Baumann M.M., Schaeffer L.E., Abbastabar H., Abd-Allah F., Abdelalim A., Abdollahpour I., Abegaz K.H., Abejie A.N., Abreu L.G., Abrigo M.R.M., Abualhasan A., Accrombessi M.M.K., Acharya D., Adabi M., Adamu A.A., Adebayo O.M., Adedoyin R.A., Adekanmbi V., Adetokunboh O.O., Adhena B.M., Afarideh M., Ahmad S., Ahmadi K., Ahmed A.E., Ahmed M.B., Ahmed R., Akalu T.Y., Alahdab F., Al-Aly Z., Alam N., Alam S., Alamene G.M., Alanzi T.M., Alcalde-Rabanal J.E., Ali B.A., Alijanzadeh M., Alipour V., Aljunid S.M., Almasi A., Almasi-Hashiani A., Al-Mekhlafi H.M., Altirkawi K.A., Alvis-Guzman N., Alvis-Zakzuk N.J., Amini S., Amit A.M.L., Andrei C.L., Anjomshoa M., Anoushiravani A., Ansari F., Antonio C.A.T., Antony B., Antriyandarti E., Arabloo J., Aref H.M.A., Aremu O., Armoon B., Arora A., Aryal K.K., Arzani A., Asadi-Aliabadi M., Atalay H.T., Athari S.S., Athari S.M., Atre S.R., Ausloos M., Awoke N., Ayala Quintanilla B.P., Ayano G., Ayanore M.A., Aynalem Y.A., Azari S., Azzopardi P.S., Babaee E., Babalola T.K., Badawi A., Bairwa M., Bakkannavar S.M., Balakrishnan S., Bali A.G., Banach M., Banoub J.A.M., Barac A., Bärnighausen T.W., Basaleem H., Basu S., Bay V.D., Bayati M., Baye E., Bedi N., Beheshti M., Behzadifar M., Behzadifar M., Bekele B.B., Belayneh Y.M., Bell M.L.

    The Lancet Global Health   Vol. 8 ( 8 ) page: e1038 - e1060   2020.8

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    Language:Japanese   Publisher:The Lancet Global Health  

    Background: Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative and absolute coverage of ORS, RHF, and ORT (use of either ORS or RHF) in LMICs. Methods: We used a Bayesian geostatistical model including 15 spatial covariates and data from 385 household surveys across 94 LMICs to estimate annual proportions of children younger than 5 years of age with diarrhoea who received ORS or RHF (or both) on continuous continent-wide surfaces in 2000–17, and aggregated results to policy-relevant administrative units. Additionally, we analysed geographical inequality in coverage across administrative units and estimated the number of diarrhoeal deaths averted by increased coverage over the study period. Uncertainty in the mean coverage estimates was calculated by taking 250 draws from the posterior joint distribution of the model and creating uncertainty intervals (UIs) with the 2·5th and 97·5th percentiles of those 250 draws. Findings: While ORS use among children with diarrhoea increased in some countries from 2000 to 2017, coverage remained below 50% in the majority (62·6%; 12 417 of 19 823) of second administrative-level units and an estimated 6 519 000 children (95% UI 5 254 000–7 733 000) with diarrhoea were not treated with any form of ORT in 2017. Increases in ORS use corresponded with declines in RHF in many locations, resulting in relatively constant overall ORT coverage from 2000 to 2017. Although ORS was uniformly distributed subnationally in some countries, within-country geographical inequalities persisted in others; 11 countries had at least a 50% difference in one of their units compared with the country mean. Increases in ORS use over time were correlated with declines in RHF use and in diarrhoeal mortality in many locations, and an estimated 52 230 diarrhoeal deaths (36 910–68 860) were averted by scaling up of ORS coverage between 2000 and 2017. Finally, we identified key subnational areas in Colombia, Nigeria, and Sudan as examples of where diarrhoeal mortality remains higher than average, while ORS coverage remains lower than average. Interpretation: To our knowledge, this study is the first to produce and map subnational estimates of ORS, RHF, and ORT coverage and attributable child diarrhoeal deaths across LMICs from 2000 to 2017, allowing for tracking progress over time. Our novel results, combined with detailed subnational estimates of diarrhoeal morbidity and mortality, can support subnational needs assessments aimed at furthering policy makers' understanding of within-country disparities. Over 50 years after the discovery that led to this simple, cheap, and life-saving therapy, large gains in reducing mortality could still be made by reducing geographical inequalities in ORS coverage. Funding: Bill & Melinda Gates Foundation.

    DOI: 10.1016/S2214-109X(20)30230-8

    Scopus

  54. Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17

    Kirsten E. Wiens, Paulina A. Lindstedt, Brigette F. Blacker, Kimberly B. Johnson, Mathew M. Baumann, Lauren E. Schaeffer, Hedayat Abbastabar, Foad Abd-Allah, Ahmed Abdelalim, Ibrahim Abdollahpour, Kedir Hussein Abegaz, Ayenew Negesse Abejie, Lucas Guimaraes Abreu, Michael R. M. Abrigo, Ahmed Abualhasan, Manfred Mario Kokou Accrombessi, Dilaram Acharya, Maryam Adabi, Abdu A. Adamu, Oladimeji M. Adebayo, Rufus Adesoji Adedoyin, Victor Adekanmbi, Olatunji O. Adetokunboh, Beyene Meressa Adhena, Mohsen Afarideh, Sohail Ahmad, Keivan Ahmadi, Anwar E. Ahmed, Muktar Beshir Ahmed, Rushdia Ahmed, Temesgen Yihunie Akalu, Fares Alahdab, Ziyad Al-Aly, Noore Alam, Samiah Alam, Genet Melak Alamene, Turki M. Alanzi, Jacqueline Elizabeth Alcalde-Rabanal, Beriwan Abdulqadir Ali, Mehran Alijanzadeh, Vahid Alipour, Syed Mohamed Aljunid, Ali Almasi, Amir Almasi-Hashiani, Hesham M. Al-Mekhlafi, Khalid A. Altirkawi, Nelson Alvis-Guzman, Nelson J. Alvis-Zakzuk, Saeed Amini, Arianna Maever L. Amit, Catalina Liliana Andrei, Mina Anjomshoa, Amir Anoushiravani, Fereshteh Ansari, Carl Abelardo T. Antonio, Benny Antony, Ernoiz Antriyandarti, Jalal Arabloo, Hany Mohamed Amin Aref, Olatunde Aremu, Bahram Armoon, Amit Arora, Krishna K. Aryal, Afsaneh Arzani, Mehran Asadi-Aliabadi, Hagos Tasew Atalay, Seyyed Shamsadin Athari, Seyyede Masoume Athari, Sachin R. Atre, Marcel Ausloos, Nefsu Awoke, Beatriz Paulina Ayala Quintanilla, Getinet Ayano, Martin Amogre Ayanore, Yared Asmare Aynalem, Samad Azari, Peter S. Azzopardi, Ebrahim Babaee, Tesleem Kayode Babalola, Alaa Badawi, Mohan Bairwa, Shankar M. Bakkannavar, Senthilkumar Balakrishnan, Ayele Geleto Bali, Maciej Banach, Joseph Adel Mattar Banoub, Aleksandra Barac, Till Winfried Barnighausen, Huda Basaleem, Sanjay Basu, Vo Dinh Bay, Mohsen Bayati, Estifanos Baye, Neeraj Bedi, Mahya Beheshti, Masoud Behzadifar, Meysam Behzadifar, Bayu Begashaw Bekele, Yaschilal Muche Belayneh, Michelle L. Bell, Derrick A. Bennett, Dessalegn Ajema Berbada, Robert S. Bernstein, Anusha Ganapati Bhat, Krittika Bhattacharyya, Suraj Bhattarai, Soumyadeep Bhaumik, Zulfiqar A. Bhutta, Ali Bijani, Boris Bikbov, Binyam Minuye Birihane, Raaj Kishore Biswas, Somayeh Bohlouli, Hunduma Amensisa Bojia, Soufiane Boufous, Oliver J. Brady, Nicola Luigi Bragazzi, Andrey Nikolaevich Briko, Nikolay Ivanovich Briko, Gabrielle B. Britton, Sharath Burugina Nagaraja, Reinhard Busse, Zahid A. Butt, Luis Alberto Camera, Ismael R. Campos-Nonato, Jorge Cano, Josip Car, Rosario Cardenas, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Wagaye Fentahun Chanie, Pranab Chatterjee, Vijay Kumar Chattu, Tesfaye Yitna Chichiabellu, Ken Lee Chin, Devasahayam J. Christopher, Dinh-Toi Chu, Natalie Maria Cormier, Vera Marisa Costa, Carlos Culquichicon, Matiwos Soboka Daba, Giovanni Damiani, Lalit Dandona, Rakhi Dandona, Anh Kim Dang, Aso Mohammad Darwesh, Amira Hamed Darwish, Ahmad Daryani, Jai K. Das, Rajat Das Gupta, Aditya Prasad Dash, Gail Davey, Claudio Alberto Davila-Cervantes, Adrian C. Davis, Dragos Virgil Davitoiu, Fernando Pio De la Hoz, Asmamaw Bizuneh Demis, Dereje Bayissa Demissie, Getu Debalkie Demissie, Gebre Teklemariam Demoz, Gebre Teklemariam Demoz, Edgar Denova-Gutierrez, Kebede Deribe, Assefa Desalew, Aniruddha Deshpande, Samath Dhamminda Dharmaratne, Preeti Dhillon, Meghnath Dhimal, Govinda Prasad Dhungana, Daniel Diaz, Isaac Oluwafemi Dipeolu, Shirin Djalalinia, Kerrie E. Doyle, Eleonora Dubljanin, Bereket Duko, Andre Rodrigues Duraes, Mohammad Ebrahimi Kalan, Hisham Atan Edinur, Andem Effiong, Aziz Eftekhari, Nevine El Nahas, Iman El Sayed, Maysaa El Sayed Zaki, Maha El Tantawi, Teshome Bekele Elema, Hala Rashad Elhabashy, Shaimaa I. El-Jaafary, Hajer Elkout, Aisha Elsharkawy, Iqbal R. F. Elyazar, Aklilu Endalamaw, Daniel Adane Endalew, Sharareh Eskandarieh, Alireza Esteghamati, Sadaf Esteghamati, Arash Etemadi, Oluchi Ezekannagha, Mohammad Fareed, Roghiyeh Faridnia, Farshad Farzadfar, Mehdi Fazlzadeh, Valery L. Feigin, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Irina Filip, Florian Fischer, Nataliya A. Foigt, Morenike Oluwatoyin Folayan, Masoud Foroutan, Richard Charles Franklin, Takeshi Fukumoto, Mohamed M. Gad, Reta Tsegaye Gayesa, Teshome Gebre, Ketema Bizuwork Gebremedhin, Gebreamlak Gebremedhn Gebremeskel, Hailay Abrha Gesesew, Kebede Embaye Gezae, Keyghobad Ghadiri, Ahmad Ghashghaee, Pramesh Raj Ghimire, Paramjit Singh Gill, Tiffany K. Gill, Themba G. Ginindza, Nelson G. M. Gomes, Sameer Vali Gopalani, Alessandra C. Goulart, Barbara Niegia Garcia Goulart, Ayman Grada, Mohammed Ibrahim Mohialdeen Gubari, Harish Chander Gugnani, Davide Guido, Rafael Alves Guimaraes, Yuming Guo, Rajeev Gupta, Nima Hafezi-Nejad, Dessalegn H. Haile, Gessessew Bugssa Hailu, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Randah R. Hamadeh, Samer Hamidi, Demelash Woldeyohannes Handiso, Hamidreza Haririan, Ninuk Hariyani, Ahmed I. Hasaballah, Md Mehedi Hasan, Edris Hasanpoor, Amir Hasanzadeh, Hadi Hassankhani, Hamid Yimam Hassen, Mohamed I. Hegazy, Behzad Heibati, Behnam Heidari, Delia Hendrie, Nathaniel J. Henry, Claudiu Herteliu, Fatemeh Heydarpour, Hagos Degefa de Hidru, Thomas R. Hird, Chi Linh Hoang, Enayatollah Homaie Rad, Praveen Hoogar, Mohammad Hoseini, Naznin Hossain, Mostafa Hosseini, Mehdi Hosseinzadeh, Mowafa Househ, Mohamed Hsairi, Guoqing Hu, Mohammedaman Mama Hussen, Segun Emmanuel Ibitoye, Ehimario U. Igumbor, Olayinka Stephen Ilesanmi, Milena D. Ilic, Mohammad Hasan Imani-Nasab, Usman Iqbal, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Chinwe Juliana Iwu, Neda Izadi, Anelisa Jaca, Nader Jahanmehr, Mihajlo Jakovljevic, Amir Jalali, Achala Upendra Jayatilleke, Ravi Prakash Jha, Vivekanand Jha, John S. Ji, Jost B. Jonas, Jacek Jerzy Jozwiak, Ali Kabir, Zubair Kabir, Amaha Kahsay, Hamed Kalani, Tanuj Kanchan, Behzad Karami Matin, Andre Karch, Mohd Anisul Karim, Hamidreza Karimi-Sari Surendra Karki, Amir Kasaeian, Gebremicheal Gebreslassie Kasahun, Yawukal Chane Kasahun, Habtamu Kebebe Kasaye, Gebrehiwot G. Kassa, Getachew Mullu Kassa, Gbenga A. Kayode, Ali Kazemi Karyani, Mihiretu M. Kebede, Peter Njenga Keiyoro, Abraham Getachew Kelbore, Andre Pascal Kengne, Daniel Bekele Ketema, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Nauman Khalid, Rovshan Khalilov, Ejaz Ahmad Khan, Junaid Khan, Md Nuruzzaman Khan, Muhammad Shahzeb Khan, Khaled Khatab, Amir M. Khater, Mona M. Khater, Maryam Khayamzadeh, Mohammad Khazaei, Salman Khazaei, Mohammad Hossein Khosravi, Jagdish Khubchandani, Ali Kiadaliri, Yun Jin Kim, Ruth W. Kimokoti, Adnan Kisa, Sezer Kisa, Niranjan Kissoon, K. M. Shivakumar, Sonali Kochhar, Tufa Kolola, Hamidreza Komaki, Soewarta Kosen, Parvaiz A. Koul, Ai Koyanagi, Moritz U. G. Kraemer, Kewal Krishan, Nuworza Kugbey, G. Anil Kumar, Manasi Kumar, Pushpendra Kumar, Vivek Kumar Dian Kusuma, Carlo La Vecchia, Ben Lacey, Sheetal D. Lad, Dharmesh Kumar Lal, Felix Lam, Faris Hasan Lami, Prabhat Lamichhane, Van Charles Lansingh, Savita Lasrado, Avula Laxmaiah, Paul H. Lee, Kate E. LeGrand, Mostafa Leili, Tsegaye Lolaso Lenjebo, Cheru Tesema Leshargie, Aubrey J. Levine, Shanshan Li, Shai Linn, Shiwei Liu, Simin Liu, Rakesh Lodha, Joshua Longbottom, Jaifred Christian F. Lopez, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, D. R. Mahadeshwara Prasad, Phetole Walter Mahasha, Narayan B. Mahotra, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Abdullah A. Mamun, Navid Manafi, Ana Laura Manda, Narendar Dawani Dawanu Manohar, Mohammad Ali Mansournia, Chabila Christopher Mapoma, Joemer C. Maravilla, Gabriel Martinez, Santi Martini, Francisco Rogerlandio Martins-Melo, Anthony Masaka, Benjamin Ballard Massenburg, Manu Raj Mathur, Benjamin K. Mayala, Mohsen Mazidi, Colm McAlinden, Birhanu Geta Meharie, Man Mohan Mehndiratta, Kala M. Mehta, Tefera Chane Mekonnen, Gebrekiros Gebremichael Meles, Peter T. N. Memiah, Ziad A. Memish, Walter Mendoza, Ritesh G. Menezes, Seid Tiku Mereta, Tuomo J. Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Kebadnew Mulatu Mihretie, Ted R. Miller, G. K. Mini, Erkin M. Mirrakhimov, Babak Moazen, Bahram Mohajer, Amjad Mohamadi-Bolbanabad, Dara K. Mohammad, Karzan Abdulmuhsin Mohammad, Yousef Mohammad, Naser Mohammad Gholi Mezerji, Roghayeh Mohammadibakhsh, Noushin Mohammadifard, Jemal Abdu Mohammed, Shafiu Mohammed, Farnam Mohebi, Ali H. Mokdad, Mariam Molokhia, Lorenzo Monasta, Yoshan Moodley, Catrin E. Moore, Ghobad Moradi, Masoud Moradi, Mohammad Moradi-Joo, Maziar Moradi-Lakeh, Paula Moraga, Linda Morales, Ilais Moreno Velasquez, Abbas Mosapour, Simin Mouodi, Seyyed Meysam Mousavi, Miliva Mozaffor, Kindie Fentahun Muchie, Getahun Fentaw Mulaw, Sandra B. Munro, Moses K. Muriithi, Christoper J. L. Murray, G. V. S. Murthy, Kamarul Imran Musa, Ghulam Mustafa, Saravanan Muthupandian, Ashraf F. Nabhan, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Kovin S. Naidoo, Gurudatta Naik, Farid Najafi, Vinay Nangia, Jobert Richie Nansseu, Bruno Ramos Nascimento, Javad Nazari, Duduzile Edith Ndwandwe, Ionut Negoi, Henok Biresaw Netsere, Josephine W. Ngunjiri, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Trang Huyen Nguyen, Dabere Nigatu, Solomon Gedlu Nigatu, Dina Nur Anggraini Ningrum, Chukwudi A. Nnaji, Marzieh Nojomi, Vuong Minh Nong, Ole F. Norheim, Jean Jacques Noubiap, Soraya Nouraei Motlagh, Bogdan Oancea, Okechukwu Samuel Ogah, Felix Akpojene Ogbo, In-Hwan Oh, Andrew T. Olagunju, Tinuke O. Olagunju, Bolajoko Olubukunola Olusanya, Jacob Olusegun Olusanya, Obinna E. Onwujekwe, Eyal Oren, Doris V. Ortega-Altamirano, Osayomwanbo Osarenotor, Frank B. Osei, Mayowa O. Owolabi, P. A. Mahesh, Jagadish Rao Padubidri, Smita Pakhale, Sangram Kishor Patel, Angel J. Paternina-Caicedo, Ashish Pathak, George C. Patton, Deepak Paudel, Kebreab Paulos, Veincent Christian Filipino Pepito, Alexandre Pereira, Norberto Perico, Aslam Pervaiz, Julia Moreira Pescarini, Bakhtiar Piroozi, Meghdad Pirsaheb, Maarten J. Postma, Hadi Pourjafar, Farshad Pourmalek, Akram Pourshams, Hossein Poustchi, Sergio I. Prada, Narayan Prasad, Liliana Preotescu, Hedley Quintana, Navid Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Afarin Rahimi-Movaghar, Vafa Rahimi-Movaghar, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Shafiur Rahman, Fatemeh Rajati, Saleem Muhammad Rana, Chhabi Lal Ranabhat, Davide Rasella, David Laith Rawaf, Salman Rawaf, Lal Rawal, Wasiq Faraz Rawasia, Vishnu Renjith, Andre M. N. Renzaho, Serge Resnikoff, Melese Abate Reta, Negar Rezaei, Mohammad Sadegh Rezai, Seyed Mohammad Riahi, Ana Isabel Ribeiro, Jennifer Rickard, Maria Rios-Blancas, Leonardo Roever, Luca Ronfani, Elias Merdassa Roro, Jennifer M. Ross, Enrico Rubagotti, Salvatore Rubino, Anas M. Saad, Yogesh Damodar Sabde, Siamak Sabour, Ehsan Sadeghi, Yahya Safari, Roya Safari-Faramani, Rajesh Sagar, Amirhossein Sahebkar, Mohammad Ali Sahraian, S. Mohammad Sajadi, Mohammad Reza Salahshoor, Nasir Salam, Payman Salamati, Hosni Salem, Marwa Rashad Salem, Yahya Salimi, Hamideh Salimzadeh, Abdallah M. Samy, Juan Sanabria, Milena M. Santric-Milicevic, Bruno Piassi Sao Jose, Sivan Yegnanarayana Iyer Saraswathy, Kaushik Sarkar, Abdur Razzaque Sarker, Nizal Sarrafzadegan, Benn Sartorius, Brijesh Sathian, Thirunavukkarasu Sathish, Monika Sawhney, Sonia Saxena, David C. Schwebel, Anbissa Muleta Senbeta, Subramanian Senthilkumaran, Sadaf G. Sepanlou, Edson Servan-Mori, Hosein Shabaninejad, Azadeh Shafieesabet, Masood Ali Shaikh, Ali S. Shalash, Seifadin Ahmed Shallo, Mehran Shams-Beyranvand, MohammadBagher Shamsi, Morteza Shamsizadeh, Mohammed Shannawaz, Kiomars Sharafi, Hamid Sharifi, Hatem Samir Shehata, Aziz Sheikh, B. Suresh Kumar Shetty, Kenji Shibuya, Wondimeneh Shibabaw Shiferaw, Desalegn Markos Shifti, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Reza Shirkoohi, Soraya Siabani, Tariq Jamal Siddiqi, Diego Augusto Santos Silva, Ambrish Singh, Jasvinder A. Singh, Narinder Pal Singh, Virendra Singh, Malede Mequanent Sisay, Eirini Skiadaresi, Mohammad Reza Sobhiyeh, Anton Sokhan, Shahin Soltani, Ranjani Somayaji, Moslem Soofi, Muluken Bekele Sorrie, Ireneous N. Soyiri, Chandrashekhar T. Sreeramareddy, Agus Sudaryanto, Mu'awiyyah Babale Sufiyan, Hafiz Ansar Rasul Suleria, Marufa Sultana, Bruno Fokas Sunguya, Bryan L. Sykes, Rafael Tabares-Seisdedos, Takahiro Tabuchi, Degena Bahrey Tadesse, Ingan Ukur Tarigan, Aberash Abay Tasew, Yonatal Mesfin Tefera, Merhawi Gebremedhin Tekle, Mohamad-Hani Temsah, Berhe Etsay Tesfay, Fisaha Haile Tesfay, Belay Tessema, Zemenu Tadesse Tessema, Kavumpurathu Raman Thankappan, Nihal Thomas, Alemayehu Toma, Roman Topor-Madry, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Khanh Bao Tran, Irfan Ullah, Bhaskaran Unnikrishnan, Muhammad Shariq Usman, Benjamin S. Chudi Uzochukwu, Pascual R. Valdez, Santosh Varughese, Francesco S. Violante, Sebastian Vollmer, Feleke Gebremeskel W. Hawariat, Yasir Waheed, Mitchell Taylor Wallin, Yafeng Wang, Yuan-Pang Wang, Marcia Weaver, Bedilu Girma Weji, Girmay Teklay Weldesamuel, Catherine A. Welgan, Andrea Werdecker, Ronny Westerman, Taweewat Wiangkham, Charles Shey Wiysonge, Haileab Fekadu Wolde, Dawit Zewdu Wondafrash, Tewodros Eshete Wonde, Getasew Taddesse Worku, Ai-Min Wu, Gelin Xu, Ali Yadollahpour, Seyed Hossein Yahyazadeh Jabbari, Tomohide Yamada, Hiroshi Yatsuya, Alex Yeshaneh, Christopher Sabo Yilgwan, Mekdes Tigistu Yilma, Paul Yip, Engida Yisma, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z. Younis, Mahmoud Yousefifard, Hebat-Allah Salah A. Yousof, Chuanhua Yu, Hasan Yusefzadeh, Siddhesh Zadey, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Hamed Zandian, Nejimu Biza Zepro, Taddese Alemu Zerfu, Yunquan Zhang, Xiu-Ju George Zhao, Arash Ziapour, Sanjay Zodpey, Yves Miel H. Zuniga, Simon I. Hay, Robert C. Reiner

    LANCET GLOBAL HEALTH   Vol. 8 ( 8 ) page: 1038 - 1060   2020.8

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    Background Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. A variety of recommended home fluids (RHF) exist as alternative forms of ORT; however, it is unclear whether RHF prevent child mortality. Previous studies have shown considerable variation between countries in ORS and RHF use, but subnational variation is unknown. This study aims to produce high-resolution geospatial estimates of relative and absolute coverage of ORS, RHF, and ORT (use of either ORS or RHF) in LMICs.Methods We used a Bayesian geostatistical model including 15 spatial covariates and data from 385 household surveys across 94 LMICs to estimate annual proportions of children younger than 5 years of age with diarrhoea who received ORS or RHF (or both) on continuous continent-wide surfaces in 2000-17, and aggregated results to policy-relevant administrative units. Additionally, we analysed geographical inequality in coverage across administrative units and estimated the number of diarrhoeal deaths averted by increased coverage over the study period. Uncertainty in the mean coverage estimates was calculated by taking 250 draws from the posterior joint distribution of the model and creating uncertainty intervals (UIs) with the 2 center dot 5th and 97 center dot 5th percentiles of those 250 draws.Findings While ORS use among children with diarrhoea increased in some countries from 2000 to 2017, coverage remained below 50% in the majority (62 center dot 6%; 12 417 of 19 823) of second administrative-level units and an estimated 6 519 000 children (95% UI 5 254 000-7 733 000) with diarrhoea were not treated with any form of ORT in 2017. Increases in ORS use corresponded with declines in RHF in many locations, resulting in relatively constant overall ORT coverage from 2000 to 2017. Although ORS was uniformly distributed subnationally in some countries, within-country geographical inequalities persisted in others; 11 countries had at least a 50% difference in one of their units compared with the country mean. Increases in ORS use over time were correlated with declines in RHF use and in diarrhoeal mortality in many locations, and an estimated 52 230 diarrhoeal deaths (36 910-68 860) were averted by scaling up of ORS coverage between 2000 and 2017. Finally, we identified key subnational areas in Colombia, Nigeria, and Sudan as examples of where diarrhoeal mortality remains higher than average, while ORS coverage remains lower than average.Interpretation To our knowledge, this study is the first to produce and map subnational estimates of ORS, RHF, and ORT coverage and attributable child diarrhoeal deaths across LMICs from 2000 to 2017, allowing for tracking progress over time. Our novel results, combined with detailed subnational estimates of diarrhoeal morbidity and mortality, can support subnational needs assessments aimed at furthering policy makers' understanding of within-country disparities. Over 50 years after the discovery that led to this simple, cheap, and life-saving therapy, large gains in reducing mortality could still be made by reducing geographical inequalities in ORS coverage. Copyright (c) 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

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  55. Cross-sectional association between working and depression prevalence in cancer survivors: a literature review Reviewed

    Atsuhiko Ota, Kenji Kawada, Akizumi Tsutsumi, Hiroshi Yatsuya

    Environmental and Occupational Health Practice   Vol. 2 ( 1 ) page: 1 - 10   2020.6

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    DOI: 10.1539/eohp.2020-0006-RA

  56. 安全衛生担当労働者における加熱式タバコの利用状況 Reviewed

    厚生の指標   Vol. 67 ( 6 ) page: 23 - 28   2020.6

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    目的 職域では受動喫煙対策とともに喫煙労働者への禁煙指導が課題となっている。日本の職域における加熱式タバコの使用実態を報告した論文は少ない。本研究の目的は,職域における加熱式タバコの使用実態を把握し,喫煙対策の実施につながる知見を得ることである。方法 某労働災害防止団体の地方センターにおいて2019年4月〜6月末の3ヵ月間に開催した安全衛生教育受講者(819人)を対象にした自記式質問紙調査を実施した。喫煙率,加熱式タバコ利用状況,年齢,性別,役職,企業規模,喫煙習慣との関連を調べた。回答者741人のうち,男性回答者で分析に必要な項目に欠損がなかった653人を解析した。結果 喫煙率は37.8%(247人)であった。現喫煙者割合は40〜49歳で高く(40.1%),過去喫煙者割合は50歳以上で高く(37.8%),非喫煙者割合は40歳未満で高かった(49.1%)(p<0.001)。役職,企業規模と現喫煙,過去喫煙,非喫煙の割合に有意な関連は認めなかった。現喫煙者247人の内,加熱式タバコのみを利用する者が67人(現喫煙者の27.1%),加熱式タバコと通常のタバコとの併用者が55人(現喫煙者の22.3%)であった。加熱式タバコの利用状況(加熱式のみ,併用,通常のタバコのみ)と年齢,役職,企業規模との間に統計学的に有意な関連は認めなかった。加熱式タバコの利用理由は「においが少ない」(67.2%),「煙が少ない」(47.5%),「火の心配が少ない」(43.4%),「自分の健康被害が少ないと思う」(35.2%),「周囲の健康被害が少ないと思う」(34.4%)であった。結論 男性労働者の喫煙率には年齢による差はあったが,企業規模や役職による差はなかった。男性労働者の加熱式タバコの利用は20%程度で,全喫煙者の約半分であった。本研究では,健康被害よりもにおいや火に関連した危険を理由として加熱式タバコを利用する者が多かった。事業場においては,通常のタバコへの喫煙対策と併せて加熱式タバコへの対策も行うことが望まれる

  57. Habitual tub bathing and risks of incident coronary heart disease and stroke. Reviewed International journal

    Tomohiko Ukai, Hiroyasu Iso, Kazumasa Yamagishi, Isao Saito, Yoshihiro Kokubo, Hiroshi Yatsuya, Isao Muraki, Ehab S Eshak, Norie Sawada, Shoichiro Tsugane

    Heart (British Cardiac Society)   Vol. 106 ( 10 ) page: 732 - 737   2020.5

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    OBJECTIVE: Tub bathing is considered to have a preventive effect against cardiovascular disease (CVD) by improving haemodynamic function. However, no prospective studies have investigated the long-term effects of tub bathing with regard to CVD risk. METHODS: A total of 30 076 participants aged 40-59 years with no history of CVD or cancer were followed up from 1990 to 2009. Participants were classified by bathing frequency: zero to two times/week, three to four times/week and almost every day. The HRs of incident CVD were estimated using Cox proportional hazards models after adjusting for traditional CVD risk factors and selected dietary factors. RESULTS: During 538 373 person-years of follow-up, we documented a total of 2097 incident cases of CVD, comprising 328 coronary heart diseases (CHDs) (275 myocardial infarctions and 53 sudden cardiac deaths) and 1769 strokes (991 cerebral infarctions, 510 intracerebral haemorrhages, 255 subarachnoid haemorrhages and 13 unclassified strokes). The multivariable HRs (95% CIs) for almost daily or every day versus zero to two times/week were 0.72 (0.62 to 0.84, trend p<0.001) for total CVD; 0.65 (0.45 to 0.94, trend p=0.065) for CHD; 0.74 (0.62 to 0.87, trend p=0.005) for total stroke; 0.77 (0.62 to 0.97, trend p=0.467) for cerebral infarction; and 0.54 (0.40 to 0.73, trend p<0.001) for intracerebral haemorrhage. No associations were observed between tub bathing frequency and risk of sudden cardiac death or subarachnoid haemorrhage. CONCLUSION: The frequency of tub bathing was inversely associated with the risk of CVD among middle-aged Japanese.

    DOI: 10.1136/heartjnl-2019-315752

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  58. ウルソデオキシコール酸添加による高脂肪食誘導性肝炎・線維化の軽減作用

    内藤 久雄, 北森 一哉, 橋本 沙幸, 浅野 友美, 八谷 寛, 那須 民江

    産業衛生学雑誌   Vol. 62 ( 臨増 ) page: 610 - 610   2020.5

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  59. Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease: The Japan Public Health Center-Based Prospective (JPHC) Study. Reviewed

    Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

    Journal of atherosclerosis and thrombosis   Vol. 27 ( 4 ) page: 363 - 374   2020.4

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    AIM: A positive association between non-high-density lipoprotein cholesterol (non-HDL-C) and coronary heart disease (CHD) has been established; however, associations between non-HDL-C and stroke subtypes have not been determined. METHODS: We conducted a prospective study of 30,554 individuals aged 40-69 yrs with no history of cardiovascular disease (CVD) in Japan. Sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of stroke subtypes and CHD were estimated according to quintiles of non-HDL-C, using Cox proportional hazard models adjusted for other established risk factors. RESULTS: We identified 1,705 stroke and 296 CHD events over a median 15 yrs of follow-up. The fractional polynomials analysis revealed a U-shaped association between non-HDL-C and stroke risk in men. When analyzed for stroke subtypes, the data revealed an inverse relationship between non-HDL-C and intracerebral hemorrhage (ICH), primarily with lobar ICH, and a positive association between non-HDL-C and large-artery occlusive infarction in men [adjusted HR 0.55 (95% CI, 0.35-0.87) and 2.05 (95% CI, 1.07-3.93) for the highest and lowest quintile of non-HDL-C, respectively]. The lowest risk of ICH in women was observed in the fourth quintile, and the lowest risk of embolic infarction was observed in the third quintile. In contrast, non-HDL-C was positively associated with CHD in both sexes. CONCLUSIONS: In Japanese men, lower non-HDL-C levels were associated with a decreased risk of large-artery occlusive infarction and an increased risk of ICH, particularly lobar ICH.

    DOI: 10.5551/jat.50385

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  60. 降圧薬ヒドララジンは高脂肪食摂取した高血圧ラットの肝線維化を抑制する

    内藤 久雄, 袁 媛, 北森 一哉, 橋本 沙幸, 浅野 友美, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 75 ( Suppl. ) page: S161 - S161   2020.3

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  61. トリクロロエチレン曝露によるCYP2E1抗体の上昇とその影響因子

    那須 民江, 王 海蘭, 袁 媛, 内藤 久雄, 伊藤 由起, 柳場 由絵, 八谷 寛, 上島 通浩

    産業衛生学雑誌   Vol. 62 ( 2 ) page: 105 - 105   2020.3

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  62. 労働者の生活習慣指導のありかた 特定健康診査による保健指導レベルと2型糖尿病発症の関連およびその人口寄与危険割合 愛知職域コホート研究

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 内藤 久雄, 太田 充彦, 玉腰 浩司, 青山 温子

    産業衛生学雑誌   Vol. 62 ( 2 ) page: 94 - 94   2020.3

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  63. 降圧薬ヒドララジンは高脂肪食摂取した高血圧ラットの肝線維化を抑制する

    内藤 久雄, 袁 媛, 北森 一哉, 橋本 沙幸, 浅野 友美, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 75 ( Suppl. ) page: S161 - S161   2020.3

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  64. Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis. Reviewed International journal

    Hiroki Miura, Yoshiki Kawamura, Fumihiko Hattori, Makito Tanaka, Kazuko Kudo, Masaru Ihira, Hiroshi Yatsuya, Yoshiyuki Takahashi, Seiji Kojima, Hirotoshi Sakaguchi, Nao Yoshida, Asahito Hama, Tetsushi Yoshikawa

    Transplant infectious disease : an official journal of the Transplantation Society   Vol. 22 ( 1 ) page: e13203   2020.2

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    BACKGROUND: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. METHODS: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV-6B infection were determined by the Cox proportional hazards model, and the clinical features of HHV-6B encephalitis in pediatric allo-HSCT patients were elucidated. RESULTS: Human herpesvirus-6B infection was observed in 74 (33.8%) of 219 patients at 3-47 days (median 18, interquartile range 13-20). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3/12.5; P < .0001), solid tumor (HR, 4.8; CI, 1.5/16.3; P = .0104), unrelated donor (HR, 2.1; CI, 1.0/4.6; P = .0378), and sex-mismatched donor (HR 1.8; CI, 1.1/3.0; P = .0257). HHV-6B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome. CONCLUSION: Hematological malignancy, solid tumor, unrelated donor, and sex-mismatched donor were significant risk factors for HHV-6B infection after pediatric allo-HSCT. In pediatric allo-HSCT patients, the incidence of HHV-6B encephalitis was low and the clinical features differed from those in adult patients.

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  65. Association of Vegetable, Fruit, and Okinawan Vegetable Consumption With Incident Stroke and Coronary Heart Disease. Reviewed

    Takahiro Yoshizaki, Junko Ishihara, Ayaka Kotemori, Junpei Yamamoto, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Kazumasa Yamagishi, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

    Journal of epidemiology   Vol. 30 ( 1 ) page: 37 - 45   2020.1

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    BACKGROUND: Few studies have investigated the effects of Okinawan vegetable consumption on the risk of incident stroke and coronary heart disease. This study aimed to examine associations of vegetable, fruit, and Okinawan vegetable consumption with risk of incident stroke and coronary heart disease in the Japanese population of Okinawa. METHODS: The study design was a prospective cohort study. During 1995-1998, a validated food frequency questionnaire was administered in two study areas to 16,498 participants aged 45-74 years. In 217,467 person-years of follow-up until the end of 2012, a total of 839 stroke cases and 197 coronary heart disease cases were identified. RESULTS: No statistically significant association between total Okinawan vegetable consumption and risk of stroke and coronary heart disease was obtained: the multivariable adjusted hazard ratios for the highest versus lowest tertile of consumption were 1.09 (95% confidence interval, 0.93-1.29; P for trend = 0.289) in model 2. Total vegetable and fruit and specific Okinawan vegetable consumption were also not statistically significantly associated with risk of cardiovascular outcomes. CONCLUSIONS: This study demonstrated that consumption of total vegetable and fruit, total Okinawan vegetables, and specific Okinawan vegetables in Japanese residents of Okinawa was not associated with risk of incident stroke and coronary heart disease.

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  66. Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies. Reviewed

    Atsushi Hozawa, Takumi Hirata, Hiroshi Yatsuya, Yoshitaka Murakami, Shinichi Kuriyama, Ichiro Tsuji, Daisuke Sugiyama, Atsushi Satoh, Sachiko Tanaka-Mizuno, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura

    Journal of epidemiology   Vol. 29 ( 12 ) page: 457 - 463   2019.12

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    BACKGROUND: We sought to investigate the optimal values of BMI for the lowest risk of all-cause death and whether the optimal BMI differs according to smoking status in large-scale pooled analysis of 13 Japanese cohorts. METHODS: Data from 179,987 participants of 13 well-qualified cohort studies conducted throughout Japan were used for our analysis. A cohort-stratified Cox proportional hazard model was used. P values for interactions were calculated based on the cross product of BMI and age, sex, or smoking status. RESULTS: In the entire study population, all-cause mortality risk was lowest when the BMI was 22.0-24.9 kg/m2. This was also the case for selected healthy participants (never smoked, baseline total cholesterol level ≥4.1 mmol/L; the first 5 years of follow-up data were excluded). No effect modification of age, sex, or smoking status was observed. Regardless of their BMI, never smokers always had a lower all-cause mortality risk than did current smokers even with an ideal BMI in terms of mortality risk. CONCLUSION: A BMI of 22-24.9 kg/m2 correlated with the lowest risk of mortality, regardless of whether all participants or selected healthy participants were analyzed. The fact that smoking was more strongly associated with mortality than obesity emphasizes the urgency for effective anti-smoking programs.

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  67. Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study. Reviewed International journal

    Utako Murai, Kazumasa Yamagishi, Mizuki Sata, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Junko Ishihara, Manami Inoue, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

    The American journal of clinical nutrition   Vol. 110 ( 6 ) page: 1449 - 1455   2019.12

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    BACKGROUND: The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established. OBJECTIVES: We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population. METHODS: We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40-69 y). Seaweed intake was determined by FFQ at baseline (1990-1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95% CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors. RESULTS: During 1,493,232 person-years of follow-up, 4777 strokes (2863 ischemic stroke, 1361 intraparenchymal hemorrhages, and 531 subarachnoid hemorrhages) and 1204 ischemic heart disease cases were identified. Among men, significant multivariable HRs (95% CIs) for almost daily consumption compared with almost no consumption of seaweed were seen in ischemic heart disease [0.76 (0.58, 0.99); P-trend = 0.04] and total cardiovascular diseases [0.88 (0.78, 1.00); P-trend = 0.08]. Among women, such inverse associations were 0.56 (0.36, 0.85; P-trend = 0.006) for ischemic heart disease and 0.89 (0.76, 1.05; P-trend = 0.10) for total cardiovascular diseases. No significant associations were observed between seaweed intake and risk of total stroke or stroke types among either men or women. CONCLUSIONS: Seaweed intake was inversely associated with risk of ischemic heart disease.

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  68. Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies. Reviewed

    Shigehisa Kajikawa, Naoyuki Imai, Shotaro Okachi, Hiroshi Yatsuya, Tomohide Souma, Toshikazu Watanabe, Yasuhiro Goto, Tomoyuki Minezawa, Naozumi Hashimoto, Kazuyoshi Imaizumi, Yoshinori Hasegawa

    Nagoya journal of medical science   Vol. 81 ( 4 ) page: 613 - 620   2019.11

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    Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUS-GS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3%, CTBB: 66.0%). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1% (17/137), compared with only 4.1% (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7% (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.

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  69. The association between weight fluctuation and all-cause mortality: A systematic review and meta-analysis. Reviewed International coauthorship International journal

    Yan Zhang, Fangfang Hou, Jiexue Li, Haiying Yu, Lu Li, Shilian Hu, Guodong Shen, Hiroshi Yatsuya

    Medicine   Vol. 98 ( 42 ) page: e17513   2019.10

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    BACKGROUND: Many observational studies have reported an association between weight fluctuation and all-cause mortality. However, the conclusions obtained from these studies have been unclear. OBJECTIVE: The current meta-analysis aimed to clarify the association between weight fluctuation and all-cause mortality. DATA SOURCE: We electronically searched PubMed, Embase, and Web of Science for articles reporting an association between weight fluctuation and all-cause mortality that were published before April 30, 2018. STUDY APPRAISAL AND SYNTHESIS METHODS: The methodological quality of each study was appraised using the modified Newcastle Ottawa Quality Assessment Scale. The hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were extracted from the included studies and pooled using random-effect models. Meta-regression approaches were also performed to explore sources of between-study heterogeneity. RESULTS: A total of 15 studies were eligible for the current meta-analysis. The pooled overall HR for all-cause mortality in the group with the greatest weight fluctuations compared with the most stable weight category was 1.45 (95% CI: 1.29-1.63). Considerable between-study heterogeneity was observed, some of which was partially explained by the different follow-up durations used by the included studies. Moreover, publication bias that inflated the risk of all-cause mortality was detected using Egger's test (P = .001). CONCLUSION: Weight fluctuation might be associated with an increased risk of all-cause mortality.

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  70. メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能 Reviewed

    金子 佳世, 八谷 寛, 李 媛英, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 青山 温子

    日本公衆衛生学会総会抄録集   Vol. 78回   page: 220 - 220   2019.10

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  71. メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能

    金子 佳世, 八谷 寛, 李 媛英, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 青山 温子

    日本公衆衛生学会総会抄録集   Vol. 78回   page: 220 - 220   2019.10

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  72. Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study. Reviewed International journal

    Li Y, Yatsuya H, Iso H, Yamagishi K, Saito I, Kokubo Y, Sawada N, Tsugane S

    Journal of epidemiology   Vol. 29 ( 9 ) page: 325 - 333   2019.9

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  73. Differences between expected and actual length of sick leave attributable to occupational accidents.

    KATOH Yoshiji, OTA Atsuhiko, YATSUYA Hiroshi

    Journal of Occupational Safety and Health   Vol. 12 ( 3 ) page: 173 - 179   2019.9

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    <p>For prevention of occupational accidents, the Labor Standards Inspection Offices evaluated the severity of the accidents based on the expected length of sick leave which was reported to the offices. Workers who met the accidents often take longer periods of sick leave than expected. We examined the excess of the length and their associations with the workers' characteristics. The subjects were 1,672 workers (1,204 men and 468 women) who met occupational accidents. 71.2% of the men and 63.9% of the women took longer periods of sick leave than expected. Men had longer expected (median: 30 days for men, 28 days for women) and actual length of sick leave (median: 50 days for men, 39 days for women) than women. The median rates of the actual sick leave periods to the expected ones were 1.38 for the men and 1.20 for the women. In men, working for the transportation/port industry, a company size of 100-299 employees, and an age of less than 30, were significantly associated with taking longer periods of sick leave than expected. The severity of occupational accidents may be underestimated if it is estimated by the expected sick leave length.</p>

    DOI: 10.2486/josh.JOSH-2019-0009-CHO

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J05150&link_issn=&doc_id=20191002450005&doc_link_id=10.2486%2Fjosh.JOSH-2019-0009-CHO&url=https%3A%2F%2Fdoi.org%2F10.2486%2Fjosh.JOSH-2019-0009-CHO&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  74. High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver. Reviewed International journal

    Naito H, Yoshikawa-Bando Y, Yuan Y, Hashimoto S, Kitamori K, Yatsuya H, Nakajima T

    Scientific reports   Vol. 9 ( 1 ) page: 12514 - 12514   2019.8

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    Precise molecular pathways involved in the progression of non-alcoholic steatohepatitis (NASH) remain to be elucidated. As Mallory-Denk bodies were occasionally observed in the enlarged hepatocytes in NASH model rat (SHRSP5/Dmcr) fed high-fat and high-cholesterol (HFC) diet, we aimed to clarify the roles of autophagy and endoplasmic reticulum (ER) stress in NASH progression. Male SHRSP5/Dmcr were randomly divided into 4 groups. Two groups were fed a control diet; the other two groups were fed a HFC diet for 2 and 8 weeks, respectively. The HFC diet increased the autophagy-related proteins levels and microtubule-associated protein 1 light chain 3-II/I ratio after 2 and 8 weeks, respectively. However, regarding ER stress-related proteins, the HFC diet decreased the levels of phosphorylated (p-) inositol-requiring kinase-1 (p-IRE-1) and p-protein kinase RNA-like ER kinase after 2 weeks. Additionally, the HFC diet increased anti-ubiquitin-positive cells and the level of the autophagy substrate p62, suggesting that the HFC diet induced dysfunction in ubiquitin-dependent protein degradation pathways. In conclusion, the HFC diet arrested the autophagy process in the liver; this was particularly associated with decreases in p-IRE-1 expression.

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  75. Automated Feedback Messages With Shichifukujin Characters Using IoT System-Improved Glycemic Control in People With Diabetes: A Prospective, Multicenter Randomized Controlled Trial. Reviewed International journal

    Tomoko Kobayashi, Kazuyo Tsushita, Eri Nomura, Akiko Muramoto, Ayako Kato, Yukari Eguchi, Takeshi Onoue, Motomitsu Goto, Shigeki Muto, Hiroshi Yatsuya, Hiroshi Arima

    Journal of diabetes science and technology   Vol. 13 ( 4 ) page: 796 - 798   2019.7

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  76. Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study. Reviewed

    Shigekazu Ukawa, Wenjing Zhao, Hiroshi Yatsuya, Kazumasa Yamagishi, Naohito Tanabe, Hiroyasu Iso, Akiko Tamakoshi

    Journal of epidemiology   Vol. 29 ( 6 ) page: 233 - 237   2019.6

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    BACKGROUND: The association between daily walking and pneumonia mortality, stratified by the presence of disease conditions, such as myocardial infarction (MI) or stroke, was investigated. METHODS: The study participants were 22,280 Japanese individuals (9,067 men and 13,213 women) aged 65-79 years. Inverse propensity weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for pneumonia mortality. RESULTS: After a median of 11.9 years of follow-up, 1,203 participants died of pneumonia. Participants who did not have a history of MI or stroke and who walked for 1 hour/day or more were less likely to die from pneumonia (HR 0.90; 95% CI, 0.82-0.98) than those walked for 0.5 hours/day. A similar inverse association of pneumonia and walking (0.5 hours/day) was observed among participants with a history of MI (HR 0.66; 95% CI, 0.48-0.90). Among the participants with a history of stroke, those who walked for 0.6-0.9 hours/day were less likely to die because of pneumonia (HR 0.65; 95% CI, 0.43-0.98). CONCLUSIONS: Regular walking for ≥1 hour/day may reduce the risk of pneumonia mortality in elderly individuals with or without cardiovascular disease history.

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  77. Socioeconomic and lifestyle factors associated with depressive tendencies in general Japanese men and women: NIPPON DATA2010. Reviewed International journal

    Harumitsu Suzuki, Aya Kadota, Nagako Okuda, Takehito Hayakawa, Nobuo Nishi, Yasuyuki Nakamura, Hisatomi Arima, Naoko Miyagawa, Atsushi Satoh, Naomi Miyamatsu, Masahiko Yanagita, Hiroshi Yatsuya, Zentaro Yamagata, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    Environmental health and preventive medicine   Vol. 24 ( 1 ) page: 37 - 37   2019.5

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    BACKGROUND: The gender-specific characteristics of individuals at an increased risk of developing depression currently remain unclear despite a higher prevalence of depression in women than in men. This study clarified socioeconomic and lifestyle factors associated with an increased risk of subclinical depression in general Japanese men and women. METHODS: Study participants were residents not receiving psychiatric treatments in 300 sites throughout Japan in 2010 (1152 men, 1529 women). Multivariable-adjusted odds ratios (OR) and 95% confidence intervals (95%CIs) for socioeconomic factors and lifestyle factors were calculated using a logistic regression analysis. RESULTS: Risk of depressive tendencies was significantly higher in men who were single and living alone (OR, 3.27; 95% CI, 1.56-6.88) than those married. The risk was significantly lower in women who were not working and aged ≥ 60 years (OR, 0.39; 95% CI, 0.22-0.68) and higher in men who were not working and aged < 60 years (OR, 3.57; 95%CI, 1.31-9.72) compared with those who were working. Current smoking was also associated with a significantly increased risk of depressive tendencies in women (OR, 2.96; 95% CI, 1.68-5.22) but not in men. CONCLUSIONS: Socioeconomic and lifestyle factors were associated with an increased risk of depressive tendencies in general Japanese. Related factors were different by sex.

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  78. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 Reviewed International coauthorship International journal

    Catherine Owens Johnson, Minh Nguyen, Gregory A. Roth, Emma Nichols, Tahiya Alam, Degu Abate, Foad Abd-Allah, Ahmed Abdelalim, Haftom Niguse Abraha, Niveen Me Abu-Rmeileh, Oladimeji M. Adebayo, Abiodun Moshood Adeoye, Gina Agarwal, Sutapa Agrawal, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Fares Alahdab, Raghib Ali, Nelson Alvis-Guzman, Nahla Hamed Anber, Mina Anjomshoa, Jalal Arabloo, Antonio Arauz, Johan Arnlov, Amit Arora, Ashish Awasthi, Maciej Banach, Miguel A. Barboza, Suzanne Lyn Barker-Collo, Till Winfried Barnighausen, Sanjay Basu, Abate Bekele Belachew, Yaschilal Muche Belayneh, Derrick A. Bennett, Isabela M. Bensenor, Krittika Bhattacharyya, Belete Biadgo, Ali Bijani, Boris Bikbov, Muhammad Shahdaat Bin Sayeed, Zahid A. Butt, Lucero Cahuana-Hurtado, Juan J. Carrero, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Ferran Catala-Lopez, Yazan Chaiah, Peggy Pei-Chia Chiang, Jee-Young J. Choi, Hanne Christensen, Dinh-Toi Chu, Monica Cortinovis, Albertino Antonio Moura Damasceno, Lalit Dandona, Rakhi Dandona, Ahmad Daryani, Kairat Davletov, Barbora De Courten, Vanessa De la Cruz-Gongora, Meaza Girma Degefa, Samath Dhamminda Dharmaratne, Daniel Diaz, Manisha Dubey, Eyasu Ejeta Duken, Dumessa Edessa, Matthias Endres, Emerito Jose A. Faraon, Farshad Farzadfar, Eduarda Fernandes, Florian Fischer, Luisa Sorio Flor, Morsaleh Ganji, Abadi Kahsu Gebre, Teklu Gebrehiwo Gebremichael, Birhanu Geta, Kebede Embaye Gezae, Paramjit Singh Gill, Elena V. Gnedovskaya, Hector Gomez-Dantes, Alessandra C. Goulart, Giuseppe Grosso, Yuming Guo, Rajeev Gupta, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Samer Hamidi, Graeme J. Hankey, Hamid Yimam Hassen, Simon I. Hay, Mohamed I. Hegazy, Behnam Heidari, Nabeel A. Herial, Mohammad Ali Hosseini, Sorin Hostiuc, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Nader Jahanmehr, Mehdi Javanbakht, Ravi Prakash Jha, Jost B. Jonas, Jacek Jerzy Jozwiak, Mikk Jurisson, Amaha Kahsay, Rizwan Kalani, Yogeshwar Kalkonde, Teshome Abegaz Kamil, Tanuj Kanchan, Andre Karch, Narges Karimi, Hamidreza Karimi-Sari, Amir Kasaeian, Tesfaye Dessale Kassa, Hossein Kazemeini, Adane Teshome Kefale, Yousef Saleh Khader, Ibrahim A. Khalil, Ejaz Ahmad Khan, Young-Ho Khang, Jagdish Khubchandani, Daniel Kim, Yun Jin Kim, Adnan Kisa, Mika Kivimaki, Ai Koyanagi, Rita K. Krishnamurthi, G. Anil Kumar, Alessandra Lafranconi, Sarah Lewington, Shanshan Li, Warren David Lo, Alan D. Lopez, Stefan Lorkowski, Paulo A. Lotufo, Mark T. Mackay, Marek Majdan, Reza Majdzadeh, Azeem Majeed, Reza Malekzadeh, Navid Manafi, Mohammad Ali Mansournia, Man Mohan Mehndiratta, Varshil Mehta, Getnet Mengistu, Atte Meretoja, Tuomo J. Meretoja, Bartosz Miazgowski, Tomasz Miazgowski, Ted R. Miller, Erkin M. Mirrakhimov, Bahram Mohajer, Yousef Mohammad, Milad Mohammadoo-Khorasani, Shafiu Mohammed, Farnam Mohebi, Ali H. Mokdad, Yaser Mokhayeri, Ghobad Moradi, Lidia Morawska, Ilais Moreno Velasquez, Seyyed Meysam Mousavi, Oumer Sada S. Muhammed, Walter Muruet, Mehdi Naderi, Mohsen Naghavi, Gurudatta Naik, Bruno Ramos Nascimento, Ruxandra Irina Negoi, Cuong Tat Nguyen, Long Hoang Nguyen, Yirga Legesse Nirayo, Bo Norrving, Jean Jacques Noubiap, Richard Ofori-Asenso, Felix Akpojene Ogbo, Andrew T. Olagunju, Tinuke O. Olagunju, Mayowa Ojo Owolabi, Jeyaraj Durai Pandian, Shanti Patel, Norberto Perico, Michael A. Piradov, Suzanne Polinder, Maarten J. Postma, Hossein Poustchi, V. Prakash, Mostafa Qorbani, Alireza Rafiei, Fakher Rahim, Kazem Rahimi, Vafa Rahimi-Movaghar, Mahfuzar Rahman, Muhammad Aziz Rahman, Cesar Reis, Giuseppe Remuzzi, Andre M. N. Renzaho, Stefano Ricci, Nicholas L. S. Roberts, Stephen R. Robinson, Leonardo Roever, Gholamreza Roshandel, Parisa Sabbagh, Hosein Safari, Saeed Safari, Saeid Safiri, Amirhossein Sahebkar, Saleh Salehi Zahabi, Abdallah M. Samy, Paola Santalucia, Itamar S. Santos, Joao Vasco Santos, Milena M. Santric Milicevic, Benn Sartorius, Arundhati R. Sawant, Aletta Elisabeth Schutte, Sadaf G. Sepanlou, Azadeh Shafieesabet, Masood Ali Shaikh, Mehran Shams-Beyranvand, Aziz Sheikh, Kevin N. Sheth, Kenji Shibuya, Mika Shigematsu, Min-Jeong Shin, Ivy Shiue, Soraya Siabani, Badr Hasan Sobaih, Luciano A. Sposato, Ipsita Sutradhar, P. A. Sylaja, Cassandra E. I. Szoeke, Braden James Te Ao, Mohamad-Hani Temsah, Omar Temsah, Amanda G. Thrift, Marcello Tonelli, Roman Topor-Madry, Bach Xuan Tran, Khanh Bao Tran, Thomas Clement Truelsen, Afewerki Gebremeskel Tsadik, Irfan Ullah, Olalekan A. Uthman, Muthiah Vaduganathan, Pascual R. Valdez, Tommi Juhani Vasankari, Rajagopalan Vasanthan, Narayanaswamy Venketasubramanian, Kia Vosoughi, Giang Thu Vu, Yasir Waheed, Elisabete Weiderpass, Kidu Gidey Weldegwergs, Ronny Westerman, Charles D. A. Wolfe, Dawit Zewdu Wondafrash, Gelin Xu, Ali Yadollahpour, Tomohide Yamada, Hiroshi Yatsuya, Ebrahim M. Yimer, Naohiro Yonemoto, Mahmoud Yousefifard, Chuanhua Yu, Zoubida Zaidi, Mohammad Zamani, Afshin Zarghi, Yunquan Zhang, Sanjay Zodpey, Valery L. Feigin, Theo Vos, Christopher J. L. Murray

    LANCET NEUROLOGY   Vol. 18 ( 5 ) page: 439 - 458   2019.5

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    Background Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016.Methods We report estimates and corresponding uncertainty intervals (UIs), from 1990 to 2016, for incidence, prevalence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). DALYs were generated by summing YLLs and YLDs. Cause-specific mortality was estimated using an ensemble modelling process with vital registration and verbal autopsy data as inputs. Non-fatal estimates were generated using Bayesian meta-regression incorporating data from registries, scientific literature, administrative records, and surveys. The Socio-demographic Index (SDI), a summary indicator generated using educational attainment, lagged distributed income, and total fertility rate, was used to group countries into quintiles.Findings In 2016, there were 5.5 million (95% UI 5.3 to 5.7) deaths and 116.4 million (111.4 to 121.4) DALYs due to stroke. The global age-standardised mortality rate decreased by 36.2% (-39.3 to -33.6) from 1990 to 2016, with decreases in all SDI quintiles. Over the same period, the global age-standardised DALY rate declined by 34.2% (-37.2 to -31.5), also with decreases in all SDI quintiles. There were 13.7 million (12.7 to 14.7) new stroke cases in 2016. Global age-standardised incidence declined by 8.1% (-10.7 to -5.5) from 1990 to 2016 and decreased in all SDI quintiles except the middle SDI group. There were 80.1 million (74.1 to 86.3) prevalent cases of stroke globally in 2016; 41.1 million (38.0 to 44.3) in women and 39.0 million (36.1 to 42.1) in men.Interpretation Although age-standardised mortality rates have decreased sharply from 1990 to 2016, the decrease in age-standardised incidence has been less steep, indicating that the burden of stroke is likely to remain high. Planned updates to future GBD iterations include generating separate estimates for subarachnoid haemorrhage and intracerebral haemorrhage, generating estimates of transient ischaemic attack, and including atrial fibrillation as a risk factor. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.

    DOI: 10.1016/S1474-4422(19)30034-1

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  79. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 Reviewed International coauthorship International journal

    Valery L. Feigin, Emma Nichols, Tahiya Alam, Marlena S. Bannick, Ettore Beghi, Natacha Blake, William J. Culpepper, E. Ray Dorsey, Alexis Elbaz, Richard G. Ellenbogen, James L. Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L. James, Catherine Owens Johnson, Nicholas J. Kassebaum, Giancarlo Logroscino, Benoit Marin, W. Cliff Mountjoy-Venning, Minh Nguyen, Richard Ofori-Asenso, Anoop P. Patel, Marco Piccininni, Gregory A. Roth, Timothy J. Steiner, Lars Jacob Stovner, Cassandra E. I. Szoeke, Alice Theadom, Stein Emil Vollset, Mitchell Taylor Wallin, Claire Wright, Joseph Raymond Zunt, Nooshin Abbasi, Foad Abd-Allah, Ahmed Abdelalim, Ibrahim Abdollahpour, Victor Aboyans, Haftom Niguse Abraha, Dilaram Acharya, Abdu A. Adamu, Oladimeji M. Adebayo, Abiodun Moshood Adeoye, Jose C. Adsuar, Mohsen Afarideh, Sutapa Agrawal, Alireza Ahmadi, Muktar Beshir Ahmed, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Rufus Olusola Akinyemi, Nadia Akseer, Ayman Al-Eyadhy, Rustam Al-Shahi Salman, Fares Alahdab, Kefyalew Addis Alene, Syed Mohamed Aljunid, Khalid Altirkawi, Nelson Alvis-Guzman, Nahla Hamed Anber, Carl Abelardo T. Antonio, Jalal Arabloo, Olatunde Aremu, Johan Arnlov, Hamid Asayesh, Rana Jawad Asghar, Hagos Tasew Atalay, Ashish Awasthi, Beatriz Paulina Ayala Quintanilla, Tambe B. Ayuk, Alaa Badawi, Maciej Banach, Joseph Adel Mattar Banoub, Miguel A. Barboza, Suzanne Lyn Barker-Collo, Till Winfried Barnighausen, Bernhard T. Baune, Neeraj Bedi, Masoud Behzadifar, Meysam Behzadifar, Yannick Bejot, Bayu Begashaw Bekele, Abate Bekele Belachew, Derrick A. Bennett, Isabela M. Bensenor, Adugnaw Berhane, Mircea Beuran, Krittika Bhattacharyya, Zulfiqar A. Bhutta, Belete Biadgo, Ali Bijani, Nigus Bililign, Muhammad Shahdaat Bin Sayeed, Christopher Kynrint Blazes, Carol Brayne, Zahid A. Butt, Ismael R. Campos-Nonato, Carlos Cantu-Brito, Mate Car, Rosario Cardenas, Juan J. Carrero, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Ferran Catala-Lopez, Ester Cerin, Yazan Chaiah, Jung-Chen Chang, Irini Chatziralli, Peggy Pei-Chia Chiang, Hanne Christensen, Devasahayam J. Christopher, Cyrus Cooper, Paolo Angelo Cortesi, Vera M. Costa, Michael H. Criqui, Christopher Stephen Crowe, Albertino Antonio Moura Damasceno, Ahmad Daryani, Vanessa De la Cruz-Gongora, Fernando Pio De la Hoz, Diego De Leo, Meaza Girma Degefa, Gebre Teklemariam Demoz, Kebede Deribe, Samath Dhamminda Dharmaratne, Daniel Diaz, Mesfin Tadese Dinberu, Shirin Djalalinia, David Teye Doku, Manisha Dubey, Eleonora Dubljanin, Eyasu Ejeta Duken, David Edvardsson, Ziad El-Khatib, Matthias Endres, Aman Yesuf Endries, Sharareh Eskandarieh, Alireza Esteghamati, Sadaf Esteghamati, Farzaneh Farhadi, Andre Faro, Farshad Farzadfar, Mohammad Hosein Farzaei, Batool Fatima, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Garumma Tolu Feyissa, Irina Filip, Florian Fischer, Takeshi Fukumoto, Morsaleh Ganji, Fortune Gbetoho Gankpe, Miguel A. Garcia-Gordillo, Abadi Kahsu Gebre, Teklu Gebrehiwo Gebremichael, Belayneh K. Gelaw, Johanna M. Geleijnse, Demeke Geremew, Kebede Embaye Gezae, Maryam Ghasemi-Kasman, Mahari Y. Gidey, Paramjit Singh Gill, Tiffany K. Gill, Elena V. Gnedovskaya, Alessandra C. Goulart, Ayman Grada, Giuseppe Grosso, Yuming Guo, Rahul Gupta, Rajeev Gupta, Juanita A. Haagsma, Tekleberhan B. Hagos, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Randah R. Hamadeh, Samer Hamidi, Graeme J. Hankey, Yuantao Hao, Josep Maria Haro, Hadi Hassankhani, Hamid Yimam Hassen, Rasmus Havmoeller, Simon I. Hay, Mohamed I. Hegazy, Behnam Heidari, Andualem Henok, Fatemeh Heydarpour, Chi Linh Hoang, Michael K. Hole, Enayatollah Homaie Rad, Seyed Mostafa Hosseini, Guoqing Hu, Ehimario U. Igumbor, Olayinka Stephen Ilesanmi, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Mihajlo Jakovljevic, Mehdi Javanbakht, Ravi Prakash Jha, Yash B. Jobanputra, Jost B. Jonas, Jacek Jerzy Jozwiak, Mikk Jurisson, Amaha Kahsay, Rizwan Kalani, Yogeshwar Kalkonde, Teshome Abegaz Kamil, Tanuj Kanchan, Manoochehr Karami, Andre Karch, Narges Karimi, Amir Kasaeian, Tesfaye Dessale Kassa, Zemenu Yohannes Kassa, Anil Kaul, Adane Teshome Kefale, Peter Njenga Keiyoro, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Ibrahim A. Khalil, Ejaz Ahmad Khan, Young-Ho Khang, Habibolah Khazaie, Aliasghar A. Kiadaliri, Daniel N. Kiirithio, Anthony S. Kim, Daniel Kim, Young-Eun Kim, Yun Jin Kim, Adnan Kisa, Yoshihiro Kokubo, Ai Koyanagi, Rita V. Krishnamurthi, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Manasi Kumar, Ben Lacey, Alessandra Lafranconi, Van C. Lansingh, Arman Latifi, Cheru Tesema Leshargie, Shanshan Li, Yu Liao, Shai Linn, Warren David Lo, Jaifred Christian F. Lopez, Stefan Lorkowski, Paulo A. Lotufo, Robyn M. Lucas, Raimundas Lunevicius, Mark T. Mackay, Narayan Bahadur Mahotra, Marek Majdan, Reza Majdzadeh, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Navid Manafi, Mohammad Ali Mansournia, Lorenzo Giovanni Mantovani, Winfried Marz, Tivani Phosa Mashamba-Thompson, Benjamin Ballard Massenburg, Kedar K. V. Mate, Colm McAlinden, John J. McGrath, Varshil Mehta, Toni Meier, Hagazi Gebre Meles, Addisu Melese, Peter T. N. Memiah, Ziad A. Memish, Walter Mendoza, Desalegn Tadese Mengistu, Getnet Mengistu, Atte Meretoja, Tuomo J. Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Tomasz Miazgowski, Ted R. Miller, G. K. Mini, Erkin M. Mirrakhimov, Babak Moazen, Bahram Mohajer, Naser Mohammad Gholi Mezerji, Moslem Mohammadi, Maryam Mohammadi-Khanaposhtani, Roghayeh Mohammadibakhsh, Mousa Mohammadnia-Afrouzi, Shafiu Mohammed, Farnam Mohebi, Ali H. Mokdad, Lorenzo Monasta, Stefania Mondello, Yoshan Moodley, Mahmood Moosazadeh, Ghobad Moradi, Maziar Moradi-Lakeh, Mehdi Moradinazar, Paula Moraga, Ilais Moreno Velasquez, Shane Douglas Morrison, Seyyed Meysam Mousavi, Oumer Sada Muhammed, Walter Muruet, Kamarul Imran Musa, Ghulam Mustafa, Mehdi Naderi, Gabriele Nagel, Aliya Naheed, Gurudatta Naik, Farid Najafi, Vinay Nangia, Ionut Negoi, Ruxandra Irina Negoi, Charles Richard James Newton, Josephine W. Ngunjiri, Cuong Tat Nguyen, Long Hoang Nguyen, Dina Nur Anggraini Ningrum, Yirga Legesse Nirayo, Molly R. Nixon, Bo Norrving, Jean Jacques Noubiap, Malihe Nourollahpour Shiadeh, Peter S. Nyasulu, Felix Akpojene Ogbo, In-Hwan Oh, Andrew T. Olagunju, Tinuke O. Olagunju, Pedro R. Olivares, Obinna E. Onwujekwe, Eyal Oren, Mayowa Ojo Owolabi, P. A. Mahesh, Amir H. Pakpour, Wen-Harn Pan, Songhomitra Panda-Jonas, Jeyaraj Durai Pandian, Sangram Kishor Patel, David M. Pereira, Max Petzold, Julian David Pillay, Michael A. Piradov, Guilherme V. Polanczyk, Suzanne Polinder, Maarten J. Postma, Richie Poulton, Hossein Poustchi, Swayam Prakash, V. Prakash, Mostafa Qorbani, Amir Radfar, Anwar Rafay, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Fatemeh Rajati, Usha Ram, Anna Ranta, David Laith Rawaf, Salman Rawaf, Nickolas Reinig, Cesar Reis, Andre M. N. Renzaho, Serge Resnikoff, Shahab Rezaeian, Mohammad Sadegh Rezai, Carlos Miguel Rios Gonzalez, Nicholas L. S. Roberts, Leonardo Roever, Luca Ronfani, Elias Merdassa Roro, Gholamreza Roshandel, Ali Rostami, Parisa Sabbagh, Ralph L. Sacco, Perminder S. Sachdev, Basema Saddik, Hosein Safari, Roya Safari-Faramani, Sare Safi, Saeid Safiri, Rajesh Sagar, Ramesh Sahathevan, Amirhossein Sahebkar, Mohammad Ali Sahraian, Payman Salamati, Saleh Salehi Zahabi, Yahya Salimi, Abdallah M. Samy, Juan Sanabria, Itamar S. Santos, Milena M. Santric Milicevic, Nizal Sarrafzadegan, Benn Sartorius, Shahabeddin Sarvi, Brijesh Sathian, Maheswar Satpathy, Arundhati R. Sawant, Monika Sawhney, Ione J. C. Schneider, Ben Schottker, David C. Schwebel, Soraya Seedat, Sadaf G. Sepanlou, Hosein Shabaninejad, Azadeh Shafieesabet, Masood Ali Shaikh, Raad A. Shakir, Mehran Shams-Beyranvand, Morteza Shamsizadeh, Mehdi Sharif, Mahdi Sharif-Alhoseini, Jun She, Aziz Sheikh, Kevin N. Sheth, Mika Shigematsu, Rahman Shiri, Reza Shirkoohi, Ivy Shiue, Soraya Siabani, Tariq J. Siddiqi, Inga Dora Sigfusdottir, Rannveig Sigurvinsdottir, Donald H. Silberberg, Joao Pedro Silva, Dayane Gabriele Alves Silveira, Jasvinder A. Singh, Dhirendra Narain Sinha, Eirini Skiadaresi, Mari Smith, Badr Hasan Sobaih, Soheila Sobhani, Moslem Soofi, Ireneous N. Soyiri, Luciano A. Sposato, Dan J. Stein, Murray B. Stein, Mark A. Stokes, Mu'awiyyah Babale Sufiyan, Bryan L. Sykes, Pn Sylaja, Rafael Tabares-Seisdedos, Braden James Te Ao, Arash Tehrani-Banihashemi, Mohamad-Hani Temsah, Omar Temsah, Jarnail Singh Thakur, Amanda G. Thrift, Roman Topor-Madry, Miguel Tortajada-Girbes, Marcos Roberto Tovani-Palone, Bach Xuan Tran, Khanh Bao Tran, Thomas Clement Truelsen, Afewerki Gebremeskel Tsadik, Lorainne Tudor Car, Kingsley Nnanna Ukwaja, Irfan Ullah, Muhammad Shariq Usman, Olalekan A. Uthman, Pascual R. Valdez, Tommi Juhani Vasankari, Rajagopalan Vasanthan, Yousef Veisani, Narayanaswamy Venketasubramanian, Francesco S. Violante, Vasily Vlassov, Kia Vosoughi, Giang Thu Vu, Isidora S. Vujcic, Fasil Shiferaw Wagnew, Yasir Waheed, Yuan-Pang Wang, Elisabete Weiderpass, Jordan Weiss, Harvey A. Whiteford, Tissa Wijeratne, Andrea Sylvia Winkler, Charles Shey Wiysonge, Charles D. A. Wolfe, Gelin Xu, Ali Yadollahpour, Tomohide Yamada, Yuichiro Yano, Mehdi Yaseri, Hiroshi Yatsuya, Ebrahim M. Yimer, Paul Yip, Engida Yisma, Naohiro Yonemoto, Mahmoud Yousefifard, Chuanhua Yu, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Hamed Zandian, Zohreh Zare, Yunquan Zhang, Sanjay Zodpey, Mohsen Naghavi, Christopher J. L. Murray, Theo Vos

    LANCET NEUROLOGY   Vol. 18 ( 5 ) page: 459 - 480   2019.5

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    Background Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247-308]) and second leading cause of deaths (9.0 million [8.8-9.4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34-44] and DALYs by 15% [9-21]) whereas their age-standardised rates decreased (deaths by 28% [26-30] and DALYs by 27% [24-31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42.2% [38.6-46.1]), migraine (16.3% [11.7-20.8]), Alzheimer's and other dementias (10.4% [9.0-124]), and meningitis (7.9% [6.6-10.4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1.12 [1.05-1.20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0.7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88.8% (86.5-90.9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22.3% [11.8-35.1] of DALYs are risk attributable) and idiopathic epilepsy (14.1% [10.8-17.5] of DALYs are risk attributable).Interpretation Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies. Copyright (C) The Author(s). Published by Elsevier Ltd.

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  80. Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up. Reviewed

    Kayo Kaneko, Hiroshi Yatsuya, Yuanying Li, Mayu Uemura, Chifa Chiang, Yoshihisa Hirakawa, Atsuhiko Ota, Koji Tamakoshi, Atsuko Aoyama

    Journal of diabetes investigation   Vol. 10 ( 3 ) page: 837 - 845   2019.5

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    AIMS/INTRODUCTION: To prospectively investigate whether simultaneous elevation of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT) is associated with the increase of type 2 diabetes mellitus incidence independent of alcohol drinking, body mass index and triglycerides. METHODS: A total of 2,775 Japanese male workers who had no history of type 2 diabetes mellitus were followed. High GGT and ALT were defined as the top tertiles (GGT cutpoint: 49 IU/L, ALT cutpoint: 28 IU/L). Three groups were created using these dichotomized GGT and ALT cutpoints: both low, either high or both high. Multivariable Cox proportional hazards models were carried out adjusted for potential confounding factors. RESULTS: A total of 276 type 2 diabetes mellitus cases were identified during 12 years (27,040 person-years) of follow up. Participants with simultaneously elevated GGT and ALT had a significantly higher incidence of type 2 diabetes mellitus, even after adjustment for fasting insulin and fasting blood glucose compared with the group without GGT or ALT elevation. Similar associations were observed in non- or light-to-moderate alcohol drinkers, as well as in participants with normal weight. However, the association was weaker in participants with triglycerides <150 mg/dL. We then evaluated whether the addition of GGT and ALT would improve the prediction of type 2 diabetes mellitus incidence, and found that their inclusion significantly increased the C-statistic, net reclassification improvement and integrated discrimination improvement. CONCLUSIONS: Simultaneous elevation of GGT and ALT was significantly associated with type 2 diabetes mellitus incidence, independent of potential confounding factors, including alcohol drinking and obesity, although the association might require concomitant elevation of triglycerides. Inclusion of GGT and ALT improved type 2 diabetes mellitus risk prediction.

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  81. 特定保健指導レベルと2型糖尿病発症の関連・その臨床疫学的指標 愛知職域コホート

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 内藤 久雄, 太田 充彦, 玉腰 浩司, 青山 温子

    産業衛生学雑誌   Vol. 61 ( 臨増 ) page: 321 - 321   2019.5

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  82. トリクロロエチレンによるCYP2E1抗体上昇とhypersensitivity syndromeとの関係

    那須 民江, 王 海蘭, 袁 媛, 内藤 久雄, 伊藤 由起, 八谷 寛, 上島 通浩

    産業衛生学雑誌   Vol. 61 ( 臨増 ) page: 332 - 332   2019.5

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  83. Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men - The Japan Public Health Center-Based Prospective Study Cohort II. Reviewed

    Rie Hayashi, Hiroyasu Iso, Kazumasa Yamagishi, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Ehab S Eshak, Norie Sawada, Shoichiro Tsugane

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 83 ( 5 ) page: 1072 - 1079   2019.4

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    BACKGROUND: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40-59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 person-years), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95% confidence interval [CI] 1.01-2.63) for acute myocardial infarction and 0.83 (95% CI 0.60-1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95% CI 1.03-4.35) and men aged 50-59 years (HR 2.60, 95% CI 1.42-4.77). CONCLUSIONS: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction.

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  84. Recent Status and Methodological Quality of Return-to-Work Rates of Cancer Patients Reported in Japan: A Systematic Review. Reviewed International journal

    Ota A, Fujisawa A, Kawada K, Yatsuya H

    International journal of environmental research and public health   Vol. 16 ( 8 )   2019.4

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  85. Validation of the Japanese Version of the Yale Food Addiction Scale 2.0 (J-YFAS 2.0). Reviewed International coauthorship

    Khine MT, Ota A, Gearhardt AN, Fujisawa A, Morita M, Minagawa A, Li Y, Naito H, Yatsuya H

    Nutrients   Vol. 11 ( 3 ) page: 687 - 687   2019.3

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    The Yale Food Addiction Scale 2.0 (YFAS 2.0) is used for assessing food addiction (FA). Our study aimed at validating its Japanese version (J-YFAS 2.0). The subjects included 731 undergraduate students. Confirmatory factor analysis indicated the root-mean-square error of approximation, comparative fit index, Tucker–Lewis index, and standardized root-mean-square residual were 0.065, 0.904, 0.880, and 0.048, respectively, for a one-factor structure model. Kuder–Richardson α was 0.78. Prevalence of the J-YFAS 2.0-diagnosed mild, moderate, and severe FA was 1.1%, 1.2%, and 1.0%, respectively. High uncontrolled eating and emotional eating scores of the 18-item Three-Factor Eating Questionnaire (TFEQ R-18) (p &lt; 0.001), a high Kessler Psychological Distress Scale score (p &lt; 0.001), frequent desire to overeat (p = 0.007), and frequent snacking (p = 0.003) were associated with the J-YFAS 2.0-diagnosed FA presence. The scores demonstrated significant correlations with the J-YFAS 2.0-diagnosed FA symptom count (p &lt; 0.01). The highest attained body mass index was associated with the J-YFAS 2.0-diagnosed FA symptom count (p = 0.026). The TFEQ R-18 cognitive restraint score was associated with the J-YFAS 2.0-diagnosed FA presence (p &lt; 0.05) and symptom count (p &lt; 0.001), but not with the J-YFAS 2.0-diagnosed FA severity. Like the YFAS 2.0 in other languages, the J-YFAS 2.0 has a one-factor structure and adequate convergent validity and reliability.

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  86. Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy. Reviewed International journal

    Ohmiya N, Hotta N, Mitsufuji S, Nakamura M, Omori T, Maeda K, Okuda K, Yatsuya H, Tajiri H

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 31 ( 2 ) page: 164 - 172   2019.3

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  87. Prevalence and Correlates of Dyslipidemia Among Men and Women in Palau: Findings of the Palau STEPS Survey 2011-2013. Reviewed International coauthorship

    Cui M, Chiang C, Cui R, Honjo K, Yatsuya H, Watson BM, Ikerdeu E, Mita T, Madraisau S, Aoyama A, Iso H

    Journal of epidemiology   Vol. 29 ( 3 ) page: 97 - 103   2019.3

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    BACKGROUND: Epidemiological evidence of dyslipidemia in Pacific Island countries is limited despite the knowledge that non-communicable diseases have a high burden in the region. We aimed to examine the prevalence and correlates of dyslipidemia among residents of Palau. METHODS: The Palau STEPwise approach to Surveillance (STEPS), which was conducted from 2011 through 2013, comprised three parts: behavioral risk factors; physical measurements; and biochemical tests, covering areas such as blood lipids. We used STEPS-generated data to perform a cross-sectional study of 2,184 randomly selected Palau residents, comprising Palauans and non-Palauans aged 25-64 years. RESULTS: The age-adjusted mean BMI was 29.3 kg/m2 in men and 29.9 kg/m2 in women; age-adjusted mean triglycerides value was 182 mg/dL in men and 166 mg/dL in women; and age-adjusted mean cholesterol was 178 mg/dL in men and 183 mg/dL in women. The prevalence of overweight/obesity (BMI ≥25 kg/m2) was 75% in men and 76% in women, and those of hypertriglyceridemia (triglycerides ≥150 mg/dL) and hypercholesterolemia (total cholesterol ≥200 mg/dL) were 48% in men and 41% in women and 18% in men and 23% in women, respectively. Mean values of total cholesterol were 177 mg/dL in Palauan men and 182 mg/dL in non-Palauan men. Mean values of triglycerides were 171 mg/dL in Palauan women and 150 mg/dL in non-Palauan women. Women living in rural areas showed a higher mean value of total cholesterol than those in urban areas. CONCLUSION: We found a high mean BMI and high prevalence of overweight/obesity and hypertriglyceridemia, but low mean total cholesterol and a low prevalence of hypercholesterolemia in Palau. Lipid profiles varied by age, ethnicity, and living area.

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  88. Sleep duration and risk of breast cancer: The JACC Study

    Cao Jinhong, Eshak Ehab S., Liu Keyang, Muraki Isao, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo

    BREAST CANCER RESEARCH AND TREATMENT   Vol. 174 ( 1 ) page: 219-225   2019.2

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    DOI: 10.1007/s10549-018-4995-4

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  89. Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium Reviewed International coauthorship International journal

    Inker L.A, Grams M.E, Levey A.S, Coresh J, Cirillo M, Collins J.F, Gansevoort R.T, Gutierrez O.M, Hamano T, Heine G.H, Ishikawa S, Jee S.H, Kronenberg F, Landray M.J, Miura K, Nadkarni G.N, Peralta C.A, Rothenbacher D, Schaeffner E, Sedaghat S, Shlipak M.G, Zhang L, van Zuilen A.D, Hallan S.I, Kovesdy C.P, Woodward M, Levin A, Astor B, Appel L, Greene T, Chen T, Chalmers J, Arima H, Perkovic V, Yatsuya H, Tamakoshi K, Li Y, Hirakawa Y, Matsushita K, Sang Y, Polkinghorne K, Chadban S, Atkins R, Djurdjev O, Liu L, Zhao M, Wang F, Wang J, Ebert N, Martus P, Tang M, Emrich I, Seiler S, Zawada A, Nally J, Navaneethan S, Schold J, Sarnak M, Katz R, Hiramoto J, Iso H, Yamagishi K, Umesawa M, Muraki I, Fukagawa M, Maruyama S, Hasegawa T, Fujii N, Wheeler D, Emberson J, Townend J, Brenner H, Sch{\"o}ttker B, Saum K.-U, Fox C, Hwang S.-J, K{\"o}ttgen A, Schneider M.P, Eckardt K.-U, Green J, Kirchner H.L, Chang A.R, Ho K, Ito S, Miyazaki M, Nakayama M, Yamada G, Irie F, Sairenchi T, Yano Y, Kotani K, Nakamura T, Kimm H, Mok Y, Chodick G, Shalev V, Wetzels J.F.M, Blankestijn P.J, van den Brand J, Kollerits B, Ritz E, Nitsch D, Roderick P, Fletcher A, Bottinger E, Ellis S.B, Nadukuru R, Ueshima H, Okayama A, Tanaka S, Okamura T, Kadota A, Kenealy T, Elley C.R, Drury P.L, Ohkubo T, Asayama K, Metoki H, Kikuya M, Nelson R.G, Knowler W.C, Bakker S.J, Hak E, Heerspink H.J.L, Brunskill N, Major R, Shepherd D, Medcalf J, Jassal S.K, Bergstrom J, Ix J.H, Barrett-Connor E, Kalantar-Zadeh K, Sumida K, Muntner P, Warnock D, McClellan W, de Zeeuw D, Brenner B, Ikram M.A, Hoorn E.J, Dehghan A, Carrero J.J, Gasparini A, Wettermark B, Elinder C.-G, Wong T.Y, Sabanayagam C, Cheng C.-Y, Visseren F.L.J, Evans M, Segelmark M, Stendahl M, Sch{\"o}n S, Tangri N, Sud M, Naimark D, Wen C.-P, Tsao C.-K, Tsai M.-K, Chen C.-H, Konta T, Hirayama A, Ichikawa K, Lannfelt L, Larsson A, A}rnl{\"o}v J, Bilo H.J.G, Landman G.W.D, van Hateren K.J.J, Kleefstra N, Coresh (Chair J, Hallan S, Ballew S.H, Chen J, Kwak L, Surapaneni A

    American Journal of Kidney Diseases   Vol. 73 ( 2 ) page: 206 - 217   2019.2

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    © 2018 National Kidney Foundation, Inc. Rationale & Objective: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework. Study Design: Cross-sectional individual participant-level analyses in a global consortium. Setting & Study Populations: 17 CKD and 38 general population and high-risk cohorts. Selection Criteria for Studies: Cohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension. Data Extraction: Data were obtained and analyzed between July 2015 and January 2018. Analytical Approach: We modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses. Results: The CKD cohorts (n = 254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n = 1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59 mL/min/1.73 m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30 mg/g). Limitations: Variations in study era, health care delivery system, typical diet, and laboratory assays. Conclusions: Lower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.

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  90. Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium

    Chang Alex R., Grams Morgan E., Ballew Shoshana H., Bilo Henk, Correa Adolfo, Evans Marie, Gutierrez Orlando M., Hosseinpanah Farhad, Iseki Kunitoshi, Kenealy Timothy, Klein Barbara, Kronenberg Florian, Lee Brian J., Li Yuanying, Miura Katsuyuki, Navaneethan Sankar D., Roderick Paul J., Valdivielso Jose M., Visseren Frank L. J., Zhang Luxia, Gansevoort Ron T., Hallan Stein I., Levey Andrew S., Matsushita Kunihiro, Shalev Varda, Woodward Mark, Astor Brad, Appel Larry, Greene, Chen Teresa, Chalmers John, Woodward Mark, Arima Hisatomi, Perkovic Vlado, Yatsuya Hiroshi, Tamakoshi Koji, Li Yuanying, Hirakawa Yoshihisa, Coresh Josef, Matsushita Kunihiro, Grams Morgan, Sang Yingying, Polkinghorne Kevan, Chadban Steven, Atkins Robert, Levin Adeera, Djurdjev Ognjenka, Dam Beaver, Klein Ron, Klein Barbara, Lee Kristine, Zhang Luxia, Liu Lisheng, Zhao Minghui, Wang Fang, Wang Jinwei, Levin Adeera, Djurdjev Ognjenka, Tang Mila, Heine Gunnar, Emrich Insa, Zawada Adam, Bauer Lucie, Nally Joseph, Navaneethan Sankar, Schold Jesse, Zhang Luxia, Zhao Minghui, Wang Fang, Wang Jinwei, Shlipak Michael, Sarnak Mark, Katz Ronit, Hiramoto Jade, Iso Hiroyasu, Yamagishi Kazumasa, Umesawa Mitsumasa, Muraki Isao, Fukagawa Masafumi, Maruyama Shoichi, Hamano Takayuki, Hasegawa Takeshi, Fujii Naohiko, Jafar Tazeen, Hatcher Juanita, Poulter Neil, Chaturvedi Nish, Wheeler David, Emberson John, Townend John, Landray Martin, Hermann, Brenner, Schottker Ben, Saum Kai-Uwe, Rothenbacher Dietrich, Fox Caroline, Hwang Shih-Jen, Kottgen Anna, Kronenberg Florian, Schneider Markus P., Eckardt Kai-Uwe, Green Jamie, Kirchner H. Lester, Chang Alex R., Ito Sadayoshi, Miyazaki Mariko, Nakayama Masaaki, Yamada Gen, Cirillo Massimo, Hallan Stein, Romundstad Solfrid, Ovrehus Marius, Langlo Knut Asbjorn, Irie Fujiko, Sairenchi Toshimi, Correa Adolfo, Rebholz Casey M., Young Bessie, Boulware L. Ebony, Ishikawa Shizukiyo, Yano Yuichiro, Kotani Kazuhiko, Nakamura Takeshi, Jee Sun Ha, Kimm Heejin, Mok Yejin, Lee Brian J., Chodick Gabriel, Shalev Varda, Wetzels Jack F. M., Blankestijn Peter J., van Zuilen Arjan D., Bots M., Sarnak Mark, Inker Lesley, Shlipak Michael, Sarnak Mark, Katz Ronit, Peralta Carmen, Kronenberg Florian, Kollerits Barbara, Ritz Eberhard, Nitsch Dorothea, Roderick Paul, Fletcher Astrid, Bottinger Erwin, Nadkarni Girish N., Ellis Stephen B., Nadukuru Rajiv, Valdivielso Jose M., Fernandez Elvira, Betriu Angels, Bermudez-Lopez Marcelino, Stengel Benedicte, Metzger Marie, Flamant Martin, Houillier Pascal, Haymann Jean-Philippe, Froissart Marc, Sang Yingying, Ueshima Hirotsugu, Okayama Akira, Miura Katsuyuki, Tanaka Sachiko, Ueshima Hirotsugu, Okamura Tomonori, Miura Katsuyuki, Tanaka Sachiko, Kenealy Timothy, Elley C. Raina, Collins John F., Drury Paul L., Ohkubo Takayoshi, Asayama Kei, Metoki Hirohito, Kikuya Masahiro, Nakayama Masaaki, Iseki Kunitoshi, Iseki Chiho, Nelson Robert G., Knowler William C., Gansevoort Ron T., Bakker Stephan J. L., Heerspink Hiddo J. L., Brunskill Nigel, Major Rupert, Shepherd David, Medcalf James, Bernardo Rancho, Jassal Simerjot K., Bergstrom Jaclyn, Joachim H., Barrett-Connor Elizabeth, Kovesdy Csaba, Kalantar-Zadeh Kamyar, Sumida Keiichi, Muntner Paul, Warnock David, Judd Suzanne, Panwar Bhupesh, Heerspink Hiddo J. L., de Zeeuw Dick, Brenner Barry, Sedaghat Sanaz, Ikram M. Arfan, Hoorn Ewout J., Dehghan Abbas, Wong Tien Yin, Sabanayagam Charumathi, Cheng Ching-Yu, Binte Riswana Banu, Sokor Mohamed Abdul, Visseren Frank L. J., Evans Marie, Segelmark Marten, Stendahl Maria, Schon Staffan, Tangri Navdeep, Sud Maneesh, Naimark David, Wen Chi-Pang, Tsao Keng, Tsai Min-Kugng, Chen Chien-Hua, Konta Tsuneo, Hirayama Atsushi, Ichikawa Kazunobu, Hosseinpanah Farhad, Hadaegh Farzad, Mirbolouk Mohammadhassan, Azizi Fereidoun, Solbu Marit Dahl, Jenssen Trond Geir, Eriksen Bjorn Odvar, Eggen Anne Elise, Lannfelt Lars, Larsson Anders, Arnlov Johan, Bilo Henk J. G., Landman Gijs W. D., Van Hateren Kornelis J. J., Kleefstra Nanne, Coresh Josef, Gansevoort Ron T., Grams Morgan E., Hallan Stein, Kovesdy Csaba P., Levey Andrew S., Matsushita Kunihiro, Shalev Varda, Woodward. Mark, Ballew Shoshana H., Chen Jingsha, Coresh Josef, Grams Morgan E., Kwak Lucia, Matsushita Kunihiro, Sang Yingying, Surapaneni Aditya, Woodward Mark

    BMJ-BRITISH MEDICAL JOURNAL   Vol. 364   2019.1

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  91. Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan) International journal

    Satoh Michihiro, Ohkubo Takayoshi, Asayama Kei, Murakami Yoshitaka, Sugiyama Daisuke, Yamada Michiko, Saitoh Shigeyuki, Sakata Kiyomi, Irie Fujiko, Sairenchi Toshimi, Ishikawa Shizukiyo, Kiyama Masahiko, Ohnishi Hirofumi, Miura Katsuyuki, Imai Yutaka, Ueshima Hirotsugu, Okamura Tomonori, Iso Hiroyasu, Kitamura Akihiko, Ninomiya Toshiharu, Kiyohara Yutaka, Nakagawa Hideaki, Nakayama Takeo, Okayama Akira, Sairenchi Toshimi, Tamakoshi Akiko, Tsuji Ichiro, Miyamoto Yoshihiro, Ishikawa Shizukiyo, Yatsuya Hiroshi, Okamura Tomonori

    HYPERTENSION   Vol. 73 ( 1 ) page: 52 - 59   2019.1

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    Lifetime risk (LTR) provides an absolute risk assessment during the remainder of one’s life. Few studies have focused on the LTRs of stroke and coronary heart disease (CHD), categorized by fine blood pressure in Asian populations. We aimed to assess it using a large database of a meta-analysis with the individual participant data. The present metaanalysis included 107 737 Japanese (42.4% men; mean age, 55.1 years) from 13 cohorts. During the mean follow-up of 15.2±5.3 years (1 559 136 person-years), 1922 died from stroke and 913 from CHD. We estimated risks after adjusting for competing risk of death other than the outcome of interest. The 10-year risk of stroke and CHD deaths at index age of 35 years was ≤1.9% and ≤0.3%, respectively. The LTRs of stroke death at the index age of 35 years (men/women) were 6.1%/4.8% for optimal, 5.7%/6.3% for normal, and 6.6%/6.0% for high-normal blood pressure groups, and 9.1%/7.9% for grade 1, 14.5%/10.3% for grade 2, and 14.6%/14.3% for grade 3 hypertension groups. The LTRs of CHD death similarly elevated with an increase in blood pressure but were lower (≤7.2%) than those of stroke death. In conclusion, blood pressure was clearly associated with an elevated LTR of stroke or CHD death, although the LTR of CHD death was one-half of that of stroke death in an Asian population. These results would help young people with hypertension to adopt a healthy lifestyle or start antihypertensive therapy early.

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  92. Smoking results in accumulation of ectopic fat in the liver. Reviewed International journal

    Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H

    Diabetes, metabolic syndrome and obesity : targets and therapy   Vol. 12   page: 1075 - 1080   2019

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    Objective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin. Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance. Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074). Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.

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  93. Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study

    Nishida Yoko, Kubota Yasuhiko, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Iso Hiroyasu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Ando Masahiko, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Fujino Yoshihisa, Shibata Akira

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   Vol. 26 ( 9 ) page: 775 - 782   2019

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  94. Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes. Reviewed International coauthorship International journal

    Crystal Man Ying Lee, Stephen Colagiuri, Mark Woodward, Edward W Gregg, Robert Adams, Fereidoun Azizi, Rafael Gabriel, Tiffany K Gill, Clicerio Gonzalez, Allison Hodge, David R Jacobs Jr Jr, Joshua J Joseph, Davood Khalili, Dianna J Magliano, Kirsten Mehlig, Roger Milne, Gita Mishra, Morgana Mongraw-Chaffin, Julie A Pasco, Masaru Sakurai, Pamela J Schreiner, Elizabeth Selvin, Jonathan E Shaw, Gary Wittert, Hiroshi Yatsuya, Rachel R Huxley

    BMJ open diabetes research & care   Vol. 7 ( 1 ) page: e000794   2019

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    Objective: There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful. Research design and methods: We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox regression models were used to obtain study-specific HRs for incident diabetes associated with each prediabetes definition. Harrell's C-statistics were used to estimate how well each prediabetes definition discriminated 5-year risk of diabetes. Spline and receiver operating characteristic curve (ROC) analyses were used to identify alternative cut-points. Results: Sixteen studies, with 76 513 participants and 8208 incident diabetes cases, were available. Compared with normoglycemia, current prediabetes definitions were associated with four to eight times higher diabetes risk (HRs (95% CIs): 3.78 (3.11 to 4.60) to 8.36 (4.88 to 14.33)) and all definitions discriminated 5-year diabetes risk with good accuracy (C-statistics 0.79-0.81). Cut-points identified through spline analysis were fasting plasma glucose (FPG) 5.1 mmol/L and glycated hemoglobin (HbA1c) 5.0% (31 mmol/mol) and cut-points identified through ROC analysis were FPG 5.6 mmol/L, 2-hour postload glucose 7.0 mmol/L and HbA1c 5.6% (38 mmol/mol). Conclusions: In terms of identifying individuals at greatest risk of developing diabetes within 5 years, using prediabetes definitions that have lower values produced non-significant gain. Therefore, deciding which definition to use will ultimately depend on the goal for identifying individuals at risk of diabetes.

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  95. Television Viewing Time and Breast Cancer Incidence or Japanese Premenopausal and Postmenopausal Women: The JACC Study

    Cao Jinhong, Eshak Ehab Salah, Liu Keyang, Muraki Isar, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo, Kurozawa Yoichi

    CANCER RESEARCH AND TREATMENT   Vol. 51 ( 4 ) page: 509 - 1517   2019

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  96. Smoking results in accumulation of ectopic fat in the liver. Reviewed

    Smoking results in accumulation of, ectopic fat in, the, liver, Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H

    Diabetes Metab Syndr Obes   Vol. 9 ( 12 ) page: 1075 - 1080   2019

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  97. Perception and practice of 'healthy' diet in relation to noncommunicable diseases among the urban and rural people in northern Ethiopia: a community-based qualitative study. Reviewed International coauthorship

    Gebremariam LW, Aoyama A, Kahsay AB, Hirakawa Y, Chiang C, Yatsuya H, Matsuyama A

    Nagoya journal of medical science   Vol. 80 ( 4 ) page: 451 - 464   2018.11

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    Dietary habits are related to the risks of noncommunicable diseases (NCDs), such as cardiovascular disease and diabetes, of which burdens are increasing in low-income countries including Ethiopia. Although several epidemiological studies of NCD risk factors were conducted in Ethiopia, qualitative studies on people's dietary habit in relation to NCDs have not been conducted yet. This study aims to describe people's perception and practice of 'healthy' diet, and barriers to practice 'healthy' diet, paying attention to the dynamics between the perception and practice. We conducted 16 key informant interviews and eight focus group discussions in an urban and a rural areas in northern Ethiopia between November 2014 and January 2016. Audio-records in local language were transcribed word-for-word, and translated into English. English text data were analyzed qualitatively, through constant comparative analysis following the principles of the grounded theory. Three themes have emerged: (1) dietary habit perceived as 'good' or 'bad' for health; (2) reasons for continuing current 'unhealthy' dietary habit; and (3) current dietary habit perceived as 'traditional.' People's practice was mostly consistent with their perception, while they sometimes practiced contrary to the perception because of personal preference and physical or financial obstacles. People were often indifferent of health implications of their habitual dietary practice, such as drinking a lot of sweet coffee. We showed dynamics between perception and practice of 'healthy' diet among people in northern Ethiopia. It is needed to increase awareness of NCDs both among the urban and rural people and to improve the social environment for removing the obstacles.

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  98. Perceptions and behavior related to noncommunicable diseases among slum dwellers in a rapidly urbanizing city, Dhaka, Bangladesh: a qualitative study. Reviewed International coauthorship

    Al-Shoaibi AAA, Matsuyama A, Khalequzzaman M, Haseen F, Choudhury SR, Hoque BA, Chiang C, Hirakawa Y, Yatsuya H, Aoyama A

    Nagoya journal of medical science   Vol. 80 ( 4 ) page: 559 - 569   2018.11

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    The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an urban slum community in Dhaka. Qualitative methods were employed to explore a general understanding of behavior related to NCDs among residents of the slum community. We conducted key informant interviews of six men and seven women of various backgrounds and five focus group discussions to focus salient topics emerged from the interviews. The transcriptions of the audio-recordings were thematically analyzed, using the constant comparison method. Four major themes emerged: (1) financial hardship influencing health; (2) urbanized lifestyle affecting diet; (3) tobacco and sweetened tea as cornerstones of social life; and (4) health-seeking behavior utilizing local resources. One notable finding was that even with general economic improvement, respondents perceived poverty to be one of the major causes of NCDs. A promising finding for potentially curbing NCDs was the current trend for women to walk for exercise contrary to the commonly held notion that urban dwellers generally lead sedentary lifestyles. This study described how urban slum dwellers in Dhaka, experiencing a transition from a traditional to urbanized lifestyle, perceived their daily practices in relation to NCDs and nutrition. Our research revealed both adverse and encouraging elements of perceptions and behavior related to NCDs, which may contribute to the optimal design of NCD prevention and health promotion programs.

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  99. Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation. Reviewed International journal

    Yasui T, Suzuki T, Yoshikawa T, Yatsuya H, Kawamura Y, Miura H, Hara F, Watanabe S, Uga N, Naoe A

    Pediatric transplantation   Vol. 22 ( 7 ) page: e13239   2018.11

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    Differentiation between active and latent viral infection is critical for analysis of HHV-6-associated disease. HHV-6 infection has been associated with several clinical manifestations; however, the precise role of HHV-6 in pediatric LDLT remains unclear. This retrospective cohort study included 33 pediatric patients who received LDLT. All of the recipients were monitored for HHV-6 infection using viral isolation and real-time PCR. HHV-6 infection was observed in 14 of 33 (42.4%) recipients, and HHV-6B infection occurred within 2 weeks after LDLT in 10 of 14 (71.4%) recipients. HHV-6 was isolated from 10 of 33 (30.3%) recipients. Multivariate analysis showed that independent predictors of HHV-6B infection were age (OR 0.975; 95% CI 0.943-0.999; P = .041), PELD (OR 1.091; P = .038), and biliary atresia (OR 16.48; P = .035). The occurrence of unexplained fever was significantly higher in recipients with HHV-6B infection (11/14) compared with uninfected recipients (6/19) (P = .013). Additionally, ALT levels at 8 and 9 weeks after transplantation were significantly higher in the recipients with HHV-6B infection. Younger age, high MELD/PELD score, and biliary atresia as an underlying disease were identified as risk factors for viral infection.

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  100. HYPERTENSION DETECTION, TREATMENT AND CONTROL RATES IN URBAN SLUM POPULATION IN BANGLADESH

    Choudhury Sohel, Al-Shoaibi Abubakr Ahmed Abdullah, Khalequzzaman Mohammad, Al Mamun Mohammad Abdullah, Chiang Chifa, Yatsuya Hiroshi, Aoyama Atsuko

    JOURNAL OF HYPERTENSION   Vol. 36   page: E337-E338   2018.10

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  101. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study. Reviewed International journal

    Kokubo Y, Saito I, Iso H, Yamagishi K, Yatsuya H, Ishihara J, Maruyama K, Inoue M, Sawada N, Tsugane S, JPHC Study Group

    Clinical nutrition (Edinburgh, Scotland)   Vol. 37 ( 5 ) page: 1602 - 1608   2018.10

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  102. γGTPとALT追加による10年間の2型糖尿病発症リスク予測能の改善 愛知職域コホート Reviewed

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 豊嶋 英明, 青山 温子

    日本公衆衛生学会総会抄録集   Vol. 77回   page: 204 - 204   2018.10

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  103. 食品摂取の多様性と尿中Na,K排泄量、血圧との関連 NIPPON DATA2010

    大塚 礼, 八谷 寛, 西 信雄, 奥田 奈賀子, 門田 文, 由田 克士, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之

    日本公衆衛生学会総会抄録集   Vol. 77回   page: 322 - 322   2018.10

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  104. The association between objective measures of residence and worksite neighborhood environment, and self-reported leisure-time physical activities: The Aichi Workers' Cohort Study. Reviewed International journal

    Yuanying Li, Hiroshi Yatsuya, Tomoya Hanibuchi, Yoshihisa Hirakawa, Atsuhiko Ota, Mayu Uemura, Chifa Chiang, Rei Otsuka, Chiyoe Murata, Koji Tamakoshi, Hideaki Toyoshima, Atsuko Aoyama

    Preventive medicine reports   Vol. 11   page: 282 - 289   2018.9

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    The possible effects of a neighborhood's built environment on physical activity have not been studied in Asian countries as much as in Western countries. The present study cross-sectionally examined the relationship between geographic information system (GIS) measured residence and worksite neighborhood walkability, and the number of parks/green spaces and sports facilities within a 1 km radius of home and workplace, with self-reported leisure-time habitual (3-4 times per week or more) walking and moderate-to-vigorous intensity habitual exercise among local government workers aged 18 to 64 years living in an urban-suburban area of Aichi, Japan in 2013. A single-level binomial regression model was used to estimate the multivariable odds ratios (ORs) and 95% confidence intervals (95% CIs). Of the 1959 male and 884 female participants, 288 (15%) and 141 (16%) reported habitual walking, respectively, and 18% and 17% reported habitual exercise, respectively. Compared with women who resided in neighborhood with a walkability index of 4-30, those living in an area with that of 35-40 were significantly more likely to engage in leisure-time habitual exercise (multivariable OR: 1.70, 95% CI: 1.08-2.68). Marginally significant positive associations were found between leisure-time habitual exercise and the residential neighborhood's number of parks/green spaces among women, as well as the number of sports facilities among men. In conclusion, a residential neighborhood environment characterized by higher walkability may contribute to the initiation or maintenance of moderate-to-vigorous intensity leisure-time exercise among working women living in an urban-suburban area of Japan.

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  105. Pooled analysis of the associations between body mass index, total cholesterol, and liver cancer-related mortality in Japan

    Ukawa S, Tamakoshi A, Murakami Y, Kiyohara Y, Yamada M, Nagai M, Satoh A, Miura K, Ueshima H, Okamura T, Imai Y, Ohkubo T, Irie F, Iso H, Kitamura A, Ninomiya T, Nakagawa H, Nakayama T, Okayama A, Sairenchi T, Saitoh S, Sakata K, Tsuji I, Kiyama M, Miyamoto Y, Ishikawa S, Yatsuya H

    Asian Pacific Journal of Cancer Prevention   Vol. 19 ( 8 ) page: 2089 - 2095   2018.8

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    © 2018 Asian Pacific Organization for Cancer Prevention. Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-related mortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on these associations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohorts without a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratified Cox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for liver cancer-related mortality. Results: A total of 447 participants (266 men and 181 women) died of liver cancer within the follow-up period. Individuals classified as having a high BMI (≥25.0 kg/m2) and low TC levels (&lt; 160 mg/dL) had a significantly increased risk for liver cancer-related mortality (HR 7.05, 95% CI 4.41-11.26 in men; HR 8.07, 95% CI 4.76-13.67 in women) when compared with those in the intermediate BMI (18.5-24.9 kg/m2) and TC (160-219 mg/dL) categories. These associations remained after limiting the

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  106. Late-phase human herpesvirus 6B reactivation in hematopoietic stem cell transplant recipients. Reviewed International journal

    Hiroki Miura, Yoshiki Kawamura, Fumihiko Hattori, Makito Tanaka, Kazuko Kudo, Masaru Ihira, Hiroshi Yatsuya, Yoshiyuki Takahashi, Seiji Kojima, Tetsushi Yoshikawa

    Transplant infectious disease : an official journal of the Transplantation Society   Vol. 20 ( 4 ) page: e12916   2018.8

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    BACKGROUND: We sought to determine whether late-phase human herpesvirus 6B (HHV-6B) infection in hematopoietic stem cell transplant (HSCT) recipients was associated with serious outcomes and mortality. METHODS: The occurrence and course of HHV-6B infection was monitored for at least 60 days after transplant using virus isolation and real-time polymerase chain reaction. Risk factors for late-phase HHV-6B infection were examined, and the propensity score was calculated with significant risk factors. The inverse probability-weighted multivariable logistic regression analysis was performed to estimate odds ratios (ORs) and the 95% confidence intervals (95% CI) for mortality. RESULTS: Late-phase HHV-6B infection was observed in 12/89 (13.5%) of the HSCT recipients. Older age (OR: 10.3, 95% CI: 2.1/72.9, P = .0027), hematologic malignancy (OR: 10.3, 95% CI: 1.8/97.1, P = .0063), unrelated donor transplantation (OR: 5.3, 95% CI: 1.1/36.0, P = .0345), and sex-mismatched donor transplantation (OR: 6.3, 95% CI: 1.4/39.5, P = .0149) were identified as risk factors for late-phase HHV-6B infection. Fifteen subjects died (17%). Inverse probability-weighted multivariable logistic model analysis revealed that late-phase HHV-6B infection was an independent risk factor for mortality (OR: 4.2, 95% CI: 1.7/11.0, P = .0012). Among 5 of the fatal cases of late-phase HHV-6B infection, viral infection might be associated with severe clinical manifestations. CONCLUSION: Late-phase HHV-6B infection in HSCT recipients was associated with worse outcomes. The full spectrum of clinical features of the infection has not been fully elucidated, and therefore, recipients with high-risk factors for late-phase HHV-6B infection should be carefully monitored.

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  107. Effect of laughter yoga on salivary cortisol and dehydroepiandrosterone among healthy university students: A randomized controlled trial Reviewed International journal

    Akiko Fujisawa, Atsuhiko Ota, Masaaki Matsunaga, Yuanying Li, Masako Kakizaki, Hisao Naito, Hiroshi Yatsuya

    Complementary Therapies in Clinical Practice   Vol. 32   page: 6 - 11   2018.8

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    Objective: To examine whether laughter yoga (LY), i.e., simulated laughter, alters cortisol and dehydroepiandrosterone (DHEA) levels and cortisol/DHEA (C/D) ratios. Methods: In a randomized controlled trial, 120 healthy university students were allocated to experiencing LY, watching a comedy movie (spontaneous laughter), or reading a book. Salivary cortisol and DHEA levels were measured immediately before, immediately after, and 30 min after the intervention. Results: Cortisol levels and C/D ratios significantly decreased by time in the LY and comedy movie groups. Significant group*time interactions were found between these two groups for cortisol levels and C/D ratios. DHEA levels did not change by time in the LY group. Conclusions: LY decreased cortisol levels and C/D ratios but did not affect DHEA levels. Simulated and spontaneous laughter differently affected the dynamics of cortisol levels and C/D ratios. Effect of spontaneous laughter on the cortisol dynamics lasted longer than that of simulated laughter. (UMIN000019409).

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  108. Cardiovascular disease mortality in relation to physical activity during adolescence and adulthood in Japan: Does school-based sport club participation matter? Reviewed International coauthorship International journal

    Gero, Krisztina, Iso, Hiroyasu, Kitamura, Akihiko, Yamagishi, Kazumasa, Yatsuya, Hiroshi, Tamakoshi, Akiko

    Preventive medicine   Vol. 113   page: 102 - 108   2018.8

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    We examined potential associations of sport club participation during adolescence and sports-related physical activity during adulthood with mortality from cardiovascular diseases (CVD) in a Japanese population. Between 1988 and 1990, 29,526 men and 41,043 women aged 40-79 years responded to a questionnaire including questions about the frequency of sports participation at baseline and sport club participation during junior/senior high school. Subjects were followed-up until the end of 2009, and 4230 cardiovascular deaths (870 CHD, 1859 stroke) were identified. Cox proportional-hazard regression models were used to estimate hazard ratios (HR). During the first-two thirds of the follow-up - where the proportional hazards assumption was met - the multivariate-adjusted HR (95% confidence interval) for total CVD mortality was 0.77 (0.61-0.98) among men and 0.82 (0.61-1.10) among women who were physically active at baseline (≥5 h/week versus 1-2 h/week). The corresponding HRs for coronary heart disease (CHD) mortality were 0.65 (0.39-1.07) and 0.40 (0.17-0.91), respectively. The combined associations of sports participation during adulthood and adolescence were also examined. Am

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  109. Non-communicable disease risk factor profile among public employees in a regional city in northern Ethiopia Reviewed International coauthorship International journal

    Lemlem Weldegerima Gebremariam, Chifa Chiang, Hiroshi Yatsuya, Esayas Haregot Hilawe, Alemayehu Bayray Kahsay, Hagos Godefay, Loko Abraham, Yoshihisa Hirakawa, Hiroyasu Iso, Atsuko Aoyama

    Scientific Reports   Vol. 8 ( 1 ) page: 9298   2018.6

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    The burden of non-communicable diseases (NCDs) is increasing in Ethiopia. This study aims to describe the prevalence of NCD risk factors of public employees in a regional city in northern Ethiopia. We conducted a cross-sectional epidemiological study targeting men and women aged 25-64 years employed by public offices in Mekelle. The prevalence was age-standardized to the Ethiopian 2007 population. Among the 1380 subjects (823 men and 557 women), 68.7% had less than 1 serving of fruits and vegetables per day, 41.0% were physically inactive, and 57.3% observed religious fast. The age-standardised prevalence of abdominal obesity was 29.3% in men and 58.5% in women, but that of metabolic syndrome was comparable between men (39.2%) and women (39.0%). The prevalence of diabetes was underestimated if only fasting blood glucose (FBG) was used for the diagnosis compared to combination of FBG and glycated haemoglobin (HbA1c) (6.7% in men and 3.8% in women vs. 12.1% in men and 5.6% in women). More than a quarter (26.1%) of men and 8.7% of women had estimated 10-year risk of cardiovascular disease of 10% or more. This study revealed the high prevalence of NCD metabolic risk factors among the urban public employees in the highland of Ethiopia.

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  110. Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH–JAPAN study

    Aya Hirata, Daisuke Sugiyama, Makoto Watanabe, Akiko Tamakoshi, Hiroyasu Iso, Kazuhiko Kotani, Masahiko Kiyama, Michiko Yamada, Shizukiyo Ishikawa, Yoshitaka Murakami, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Toshiharu Ninomiya, Yutaka Kiyohara, Katsuyuki Miura, Yoshitaka Murakami, Hideaki Nakagawa, Takeo Nakayama, Akira Okayama, Toshimi Sairenchi, Shigeyuki Saitoh, Kiyomi Sakata, Akiko Tamakoshi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya, Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH–JAPAN) Research Group

    Journal of Clinical Lipidology   Vol. 12 ( 3 ) page: 674 - 684.e5   2018.5

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    Background: The effect of very high or extremely high levels of high-density lipoprotein cholesterol (HDL-C) on cardiovascular disease (CVD) is not well described. Although a few recent studies have reported the adverse effects of extremely high levels of HDL-C on CVD events, these did not show a statistically significant association between extremely high levels of HDL-C and cause-specific CVD mortality. In addition, Asian populations have not been studied. Objective: We examine the impact of extremely high levels of HDL-C on cause-specific CVD mortality using pooled data of Japanese cohort studies. Methods: We performed a large-scale pooled analysis of 9 Japanese cohorts including 43,407 participants aged 40–89 years, dividing the participants into 5 groups by HDL-C levels, including extremely high levels of HDL-C ≥2.33 mmol/L (≥90 mg/dL). We estimated the adjusted hazard ratio of each HDL-C category for all-cause death and cause-specific deaths compared with HDL-C 1.04–1.55 mmol/L (40–59 mg/dL) using a cohort-stratified Cox proportional hazards model. Results: During a 12.1-year follow-up, 4995 all-cause deaths and 1280 deaths due to overall CVD were identified. Extremely high levels of HDL-C were significantly associated with increased risk of atherosclerotic CVD mortality (hazard ratio = 2.37, 95% confidence interval: 1.37–4.09 for total) and increased risk for coronary heart disease and ischemic stroke. In addition, the risk for extremely high HDL-C was more evident among current drinkers. Conclusion: We showed extremely high levels of HDL-C had an adverse effect on atherosclerotic CVD mortality in a pooled analysis of Japanese cohorts.

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  111. 降圧剤の投与は高血圧ラット肝臓Cyp7a1プロモーターのメチル化頻度を低下させる

    内藤 久雄, 三宅 邦夫, 袁 援, 橋本 沙幸, 浅野 友美, 北森 一哉, 八谷 寛, 那須 民江

    産業衛生学雑誌   Vol. 60 ( 臨増 ) page: 303 - 303   2018.5

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  112. Association between average daily television viewing time and the incidence of ovarian cancer: findings from the Japan Collaborative Cohort Study. Reviewed International journal

    Shigekazu Ukawa, Akiko Tamakoshi, Mitsuru Mori, Satoyo Ikehara, Toru Shirakawa, Hiroshi Yatsuya, Hiroyasu Iso

    Cancer causes & control : CCC   Vol. 29 ( 2 ) page: 213 - 219   2018.2

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    PURPOSE: Seventy-five percent of epidemiological studies have reported that sedentary behavior is associated with ovarian cancer incidence. Although Japan has one of the most sedentary populations, with median sitting times of 7 h/day, this association has not been investigated. This study aimed to elucidate the association between average daily television (TV) viewing time, which is a major sedentary behavior, and the incidence of ovarian cancer in a large-scale nationwide cohort study in Japan. METHODS: A total of 34,758 female participants aged 40-79 years without a history of cancer at baseline were included in the study. The inverse probability weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the incidence of ovarian cancer. RESULTS: During a median follow-up of 19.4 years, 59 participants developed ovarian cancer (ICD-10: C56), 2,706 participants developed other types of cancer, and 4,318 participants died. Participants who watched TV for ≥ 5 h/day were more likely to develop ovarian cancer than those who watched TV for < 2 h/day (HR 2.15; 95% CI 1.54-2.99). CONCLUSION: Our findings suggest that reducing the amount of time spent sedentarily may be beneficial for preventing ovarian cancer.

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  113. Relationships among Socioeconomic Factors and Self-rated Health in Japanese Adults: NIPPON DATA2010. Reviewed International journal

    Ota A, Yatsuya H, Nishi N, Okuda N, Ohkubo T, Hayakawa T, Kadota A, Okayama A, Miura K

    Journal of epidemiology   Vol. 28 ( Supplement_III ) page: S66 - S72   2018

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  114. A Point System for Predicting 10-Year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study. Reviewed

    Yatsuya H, Li Y, Hirakawa Y, Ota A, Matsunaga M, Haregot HE, Chiang C, Zhang Y, Tamakoshi K, Toyoshima H, Aoyama A

    Journal of epidemiology   Vol. 28 ( 8 ) page: 347 - 352   2018

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    BACKGROUND: Relatively little evidence exists for type 2 diabetes mellitus (T2DM) prediction models from long-term follow-up studies in East Asians. This study aims to develop a point-based prediction model for 10-year risk of developing T2DM in middle-aged Japanese men. METHODS: We followed 3,540 male participants of Aichi Workers' Cohort Study, who were aged 35-64 years and were free of diabetes in 2002, until March 31, 2015. Baseline age, body mass index (BMI), smoking status, alcohol consumption, regular exercise, medication for dyslipidemia, diabetes family history, and blood levels of triglycerides (TG), high density lipoprotein cholesterol (HDLC) and fasting blood glucose (FBG) were examined using Cox proportional hazard model. Variables significantly associated with T2DM in univariable models were simultaneously entered in a multivariable model for determination of the final model using backward variable selection. Performance of an existing T2DM model when applied to the current dataset was compared to that obtained in the present study's model. RESULTS: During the median follow-up of 12.2 years, 342 incident T2DM cases were documented. The prediction system using points assigned to age, BMI, smoking status, diabetes family history, and TG and FBG showed reasonable discrimination (c-index: 0.77) and goodness-of-fit (Hosmer-Lemeshow test, P = 0.22). The present model outperformed the previous one in the present subjects. CONCLUSION: The point system, once validated in the other populations, could be applied to middle-aged Japanese male workers to identify those at high risk of developing T2DM. In addition, further investigation is also required to examine whether the use of this system will reduce incidence.

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  115. [Study on the probability of incident stroke and acute myocardial infarction using DPC data]. Reviewed

    Masako Kakizaki, Norie Sawada, Kazumasa Yamagishi, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Hiroyasu Iso, Shoichiro Tsugane, Hideo Yasunaga

    [Nihon koshu eisei zasshi] Japanese journal of public health   Vol. 65 ( 4 ) page: 179 - 186   2018

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  116. 肥満と動脈硬化

    八谷 寛, 李 媛英, 金子 佳世, 太田 充彦

    食と医療   Vol. 4   page: 72 - 79   2018

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  117. Prevalence of non-communicable disease risk factors among poor shantytown residents in Dhaka, Bangladesh: a community-based cross-sectional survey. Reviewed International coauthorship International journal

    Khalequzzaman M, Chiang C, Choudhury SR, Yatsuya H, Al-Mamun MA, Al-Shoaibi AAA, Hirakawa Y, Hoque BA, Islam SS, Matsuyama A, Iso H, Aoyama A

    BMJ open   Vol. 7 ( 11 ) page: e014710   2017.11

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    OBJECTIVES: This study aims to describe the prevalence of non-communicable disease (NCD) risk factors among the urban poor in Bangladesh. DESIGN: We conducted a community-based cross-sectional epidemiological study. SETTING: The study was conducted in a shantytown in the city of Dhaka. There were 8604 households with 34 170 residents in the community. Those households were categorised into two wealth strata based on the housing structure. PARTICIPANTS: The study targeted residents aged 18-64 years. A total of 2986 eligible households with one eligible individual were selected by simple random sampling stratified by household wealth status. A total of 2551 residents completed the questionnaire survey, and 2009 participated in the subsequent physical and biochemical measurements. OUTCOME MEASURES: A modified WHO survey instrument was used for assessing behavioural risk factors and physical and biochemical measurements, including glycated haemoglobin (HbA1c). The prevalence of NCD risk factors, such as tobacco use, fruit and vegetable intake, overweight/obesity, hypertension, diabetes (HbA1c ≥6.5%) and dyslipidaemia, was described according to household wealth status and gender differences. RESULTS: The prevalence of current tobacco use was 60.4% in men and 23.5% in women. Most of them (90.8%) consumed more than 1 serving of fruits and vegetables per day; however, only 2.1% consumed more than 5 servings. Overweight/obesity was more common in women (39.2%) than in men (18.9%), while underweight was more common in men (21.0%) than in women (7.1%). The prevalence of hypertension was 18.6% in men and 20.7% in women. The prevalence of diabetes was 15.6% in men and 22.5% in women, which was much higher than the estimated national prevalence (7%). The prevalence of raised total cholesterol (≥190 mg/dL) was 25.7% in men and 34.0% in women. CONCLUSION: The study identified that tobacco use, both overweight and underweight, diabetes, hypertension and dyslipidaemia were prevalent among the urban poor in Bangladesh.

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  118. Alcohol consumption and mortality from aortic disease among Japanese men: The Japan Collaborative Cohort study Reviewed International journal

    Toru Shirakawa, Kazumasa Yamagishi, Hiroshi Yatsuya, Naohito Tanabe, Akiko Tamakoshi, Hiroyasu Iso

    ATHEROSCLEROSIS   Vol. 266   page: 64 - 68   2017.11

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    Background and aims: Only a few population-based prospective studies have examined the association between alcohol consumption and abdominal aortic aneurysm, and the results are inconsistent. Moreover, no evidence exists for aortic dissection. We examined the effect of alcohol consumption on risk of mortality from aortic diseases.
    Methods: A total of 34,720 men from the Japan Collaborative Cohort study, aged 40-79 years, without history of cardiovascular disease and cancer at baseline 1988 and 1990 were followed up until the end of 2009 for their mortality and its underlying cause. Hazard ratios of mortality from aortic diseases were estimated according to alcohol consumption categories of never-drinkers, ex-drinkers, regular drinkers of &lt;= 30 g, and &gt; 30 g ethanol per day.
    Results: During the median 17.9-year follow-up period, 45 men died of aortic dissection and 41 men died of abdominal aortic aneurysm. Light to moderate drinkers of &lt;= 30 g ethanol per day had lower risk of mortality from total aortic disease and aortic dissection compared to never-drinkers. The respective multivariable hazard ratios (95% confidence intervals) were 0.46 (0.28-0.76) for total aortic disease and 0.16 (0.05-0.50) for aortic dissection. Heavy drinkers of &gt; 30 g ethanol per day did not have reduced risk of mortality from total aortic disease, albeit had risk variation between aortic dissection and abdominal aortic aneurysm.
    Conclusions: Light to moderate alcohol consumption was associated with reduced mortality from aortic disease among Japanese men. (C) 2017 Published by Elsevier Ireland Ltd.

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  119. Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study Reviewed International journal

    Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

    ATHEROSCLEROSIS   Vol. 265   page: 147 - 154   2017.10

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    Background and aims: Although low high-density lipoprotein (HDL) cholesterol concentration is an established risk factor for coronary heart disease (CHD), information regarding subtypes of stroke is very limited, especially in Asian populations.
    Methods: A prospective study was conducted among 30,736 individuals aged 40-69 years, who lived in nine communities in Japan and did not have a history of cardiovascular disease (CVD). CHD and stroke, including its subtypes, were assessed, and sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were estimated according to quintiles of HDL cholesterol using Cox proportional models adjusted for other CVD risk factors.
    Results: We identified 296 CHD and 1712 stroke events over a median 15 yr of follow-up. HDL cholesterol concentration showed an inverse association with CHD in men and women. A low HDL cholesterol concentration slightly raised the risk for total strokes in men, but not in women. When analyzed by subtypes, we observed an inverse relationship between HDL cholesterol concentration and the incidence of lacunar infarction, with an adjusted HR for the lowest quintile of HDL cholesterol concentration compared with the highest quintile of 1.63 (95% CI, 1.00-2.66) in men and 1.97 (95% CI, 1.19-3.26) in women. HDL cholesterol concentration was positively associated with the risk of intracerebral hemorrhage (ICH) in a linear manner in women (p for trend = 0.028), but not in men.
    Conclusions: The associations of HDL cholesterol concentration with lacunar infarction and ICH may be related to different functional properties of HDL rather than to its protective function against lipid-rich atherosclerosis. (C) 2017 Elsevier B.V. All rights reserved.

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  120. Functional capacity, self-rated health status, and psychosocial characteristics of employed cancer survivors in Japan Reviewed

    Katoh Y, Ota A, Yatsuya H, Li Y, Naito H, Fujisawa A, Matsunaga M, Hirakawa Y, Chiang C, Toyoshima H, Tamakoshi K, Aoyama A

    Fujita Medical Journal   Vol. 3 ( 3 ) page: 55 - 61   2017.8

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    <p><b>Objectives:</b> This study investigated restrictions in functional capacity, self-rated health status (SRHS), and psychosocial characteristics of employed cancer survivors in Japan and examined differences in these characteristics between cancer survivors and employees without cancer history.</p><p><b>Methods:</b> A cross-sectional survey was carried out. Subjects were local government employees in Japan in 2013 (n=5,474). Using a self-administered questionnaire, we evaluated restrictions in functional capacity, SRHS, and the following psychosocial characteristics: social support, perceived stress, social capital, positive reasons for living (ikigai), and happiness. We examined whether cancer history was associated with restrictions in functional capacity, SRHS, and psychosocial characteristics.</p><p><b>Results:</b> A total of 112 employees were cancer survivors. Of these, males of all ages and comparatively younger females had restrictions in functional capacity more frequently than the corresponding subjects without cancer history (males of all ages: 14.5% vs. 2.9%, p<0.001; females <50 years: 15.2% vs. 1.1%, p<0.001). Among males of all ages, cancer survivors reported bad SRHS more frequently than employees without cancer history (8.1% vs. 1.5%, p=0.003). No significant differences were found in psychosocial characteristics by cancer history.</p><p><b>Conclusions:</b> Male and comparatively young female employed cancer survivors frequently experienced restrictions in functional capacity. Male employed cancer survivors self-rated their health status as bad more frequently than male employees without cancer history.</p>

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  121. A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan Reviewed

    Takumi Hirata, Daisuke Sugiyama, Shin-ya Nagasawa, Yoshitaka Murakami, Shigeyuki Saitoh, Akira Okayama, Hiroyasu Iso, Fujiko Irie, Toshimi Sairenchi, Yoshihiro Miyamoto, Michiko Yamada, Shizukiyo Ishikawa, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, for the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Yutaka Kiyohara, Katsuyuki Miura, Yoshitaka Murakami, Hideaki Nakagawa, Takeo Nakayama, Akira Okayama, Toshimi Sairenchi, Shigeyuki Saitoh, Kiyomi Sakata, Akiko Tamakoshi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya, Tomonori Okamura

    European Journal of Epidemiology   Vol. 32 ( 7 ) page: 547 - 557   2017.7

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    Low levels of serum high-density lipoprotein cholesterol (HDL-C) have been shown to be associated with increased risk of coronary heart disease (CHD). However, because this is usually observed in the context of other lipid abnormalities, it is not known whether isolated low serum HDL-C levels are an independent risk factor for CHD. We performed a large pooled analysis in Japan using data from nine cohorts with 41,206 participants aged 40–89 years who were free of cardiovascular disease at baseline. We divided participants into three groups: isolated low HDL-C, non-isolated low HDL-C, and normal HDL-C. Cohort-stratified Cox proportional hazards models were used to estimate multivariate-adjusted hazard ratios (HRs) for death due to CHD, ischemic stroke, and intracranial cerebral hemorrhage
    during a 12.9-year follow-up, we observed 355, 286, and 138 deaths, respectively, in these groups. Non-isolated low HDL-C was significantly associated with increased risk of CHD compared with normal HDL-C (HR 1.37, 95 % confidence interval (CI) 1.04–1.80)
    however, isolated low HDL-C was not. Although isolated low HDL-C was significantly associated with decreased risk of CHD (HR 0.51, 95 % CI 0.29–0.89) in women, it was significantly associated with increased risk of intracranial cerebral hemorrhage in all participants (HR 1.62, 95 % CI 1.04–2.53) and in men (HR 2.00, 95 % CI 1.04–3.83). In conclusion, isolated low HDL-C levels are not associated with increased risk of CHD in Japan. CHD risk may, therefore, be more strongly affected by serum total cholesterol levels in this population.

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  122. Synergistic and Non-synergistic Associations for Cigarette Smoking and Non-tobacco Risk Factors for Cardiovascular Disease Incidence in the Atherosclerosis Risk In Communities (ARIC) Study Reviewed International coauthorship International journal

    Jay H. Lubin, David Couper, Pamela L. Lutsey, Hiroshi Yatsuya

    NICOTINE & TOBACCO RESEARCH   Vol. 19 ( 7 ) page: 826 - 835   2017.7

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    Cigarette smoking, various metabolic and lipid-related factors and hypertension are well-recognized cardiovascular disease (CVD) risk factors. Since smoking affects many of these factors, use of a single imprecise smoking metric, for example, ever or never smoked, may allow residual confounding and explain inconsistencies in current assessments of interactions.
    Using a comprehensive model in pack-years and cigarettes/day for the complex smoking-related relative risk (RR) of CVD to reduce residual confounding, we evaluated interactions with non-tobacco risk factors, including additive (non-synergistic) and multiplicative (synergistic) forms. Data were from the prospective Atherosclerosis Risk in Communities (ARIC) Study from four areas of the United States recruited in 1987-1989 with follow-up through 2008. Analyses included 14 127 participants, 207 693 person-years and 2857 CVD events.
    Analyses revealed distinct interactions with smoking: including statistical consistency with additive (body mass index [BMI], waist to hip ratio [WHR], diabetes mellitus [DM], glucose, insulin, high density lipoproteins [HDL] and HDL(2)); and multiplicative (hypertension, total cholesterol [TC], low density lipoproteins [LDLs], apolipoprotein B [apoB], TC to HDL ratio and HDL(3)) associations, as well as indeterminate (apolipoprotein A-I [apoA-I] and triglycerides) associations.
    The forms of the interactions were revealing but require confirmation. Improved understanding of joint associations may help clarify the public health burden of smoking for CVD, links between etiologic factors and biological mechanisms, and the consequences of joint exposures, whereby synergistic associations highlight joint effects and non-synergistic associations suggest distinct contributions.
    Joint associations for cigarette smoking and non-tobacco risk factors were distinct, revealing synergistic/multiplicative (hypertension, TC, LDL, apoB, TC/HDL, HDL(3)), non-synergistic/additive (BMI, WHR, DM, glucose, insulin, HDL, HDL(2)) and indeterminate (apoA-I and TRIG) associations. If confirmed, these results may help better define the public health burden of smoking on CVD risk and identify links between etiologic factors and biologic mechanisms, where synergistic associations highlight joint impacts and non-synergistic associations suggest distinct contributions from each factor.

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  123. Similarities and differences between coronary heart disease and stroke in the associations with cardiovascular risk factors: The Japan Collaborative Cohort Study Reviewed International journal

    Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Kentaro Yamashita, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Chaochen Wang, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi

    ATHEROSCLEROSIS   Vol. 261   page: 124 - 130   2017.6

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    Background and aims: Coronary heart disease (CHD) and stroke have common risk factors, but some of these differ in the magnitude or direction of associations between CHD and stroke. We assessed whether the impact of each risk factor differed between CHD and stroke mortality in Asians.
    Methods: In total, 104 910 subjects aged 40-79 years without histories of cancer, CHD and stroke at baseline were followed between 1988 and 2009. Competing- risks analysis was used to test for differences in the associations of each risk factor with two endpoints (CHD and stroke). Population attributable fractions (PAFs) were also calculated for these endpoints to estimate the population impact of each risk factor.
    Results: During a median 19.1-year follow-up, 1554 died from CHD and 3163 from stroke. The association of hypertension with CHD was similar to that with stroke in terms of the magnitude and direction (multivariable-adjusted hazard ratio for CHD: 1.63 vs. stroke: 1.73 in men and 1.70 vs. 1.66 in women). Conversely, the magnitude of these associations differed for smoking (CHD: 1.95 vs. stroke: 1.23 in men and 2.45 vs. 1.35 in women) and diabetes (1.49 vs. 1.09 in men and 2.08 vs. 1.39 in women). The highest PAF for CHD was caused by smoking in men and by hypertension in women; that for stroke was caused by hypertension in both sexes.
    Conclusions: Hypertension associations and PAFs were consistent between CHD and stroke, but not for other risk factors. These findings may be useful to optimize public health intervention strategies. (C) 2017 Elsevier B.V. All rights reserved.

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  124. Passive smoking and chronic obstructive pulmonary disease mortality: findings from the Japan collaborative cohort study Reviewed International journal

    Shigekazu Ukawa, Akiko Tamakoshi, Hiroshi Yatsuya, Kazumasa Yamagishi, Masahiko Ando, Hiroyasu Iso

    INTERNATIONAL JOURNAL OF PUBLIC HEALTH   Vol. 62 ( 4 ) page: 489 - 494   2017.5

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    To elucidate the association between passive smoking at home and chronic obstructive pulmonary disease (COPD) mortality via a large-scale nationwide cohort study in Japan.
    Never smokers (n = 34,604) aged 40-79 years at baseline (1988-1990; 4884 men, 29,720 women) were included in the analysis. Passive smoking at home was measured based on self-reported frequency of weekly exposure to passive smoking at home. An inverse probability of treatment-weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for COPD mortality.
    During a median follow-up of 16.4 years, 33 participants (10 men, 23 women) died of COPD. The HR for participants exposed to passive smoking at home ae&lt;currency&gt;4 days per week or those who had almost daily exposure to passive smoking at home had a significantly increased risk of COPD mortality (HR 2.40, 95% CI 1.39-4.15, HR 2.88, 95% CI 1.68-4.93, respectively).
    The present findings suggest that avoiding passive smoking at home may be beneficial for preventing death due to COPD among never smokers.

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  125. Descriptive Epidemiology of Hypertension and Its Association With Obesity: Based on the WHO STEPwise Approach to Surveillance in Palau Reviewed International coauthorship International journal

    Chaochen Wang, Chifa Chiang, Hiroshi Yatsuya, Esayas Haregot Hilawe, Edolem Ikerdeu, Kaori Honjo, Takashi Mita, Renzhe Cui, Yoshihisa Hirakawa, Sherilynn Madraisau, Hiroyasu Iso, Atsuko Aoyama

    ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH   Vol. 29 ( 4 ) page: 278 - 287   2017.5

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    The rise of noncommunicable diseases is a serious health burden for Palau. This study described the prevalence of hypertension, and assessed its association with obesity. Surveys following the WHO STEPwise approach to surveillance were conducted in 2529 adults. Multivariate prevalence ratios (PR) of hypertension for body mass index (BMI) categories were calculated by logistic regression models using conditional standardization procedure. Age- and sex-specified analyses were performed. Overall prevalence of obesity and hypertension were 40.4% and 46.8%, respectively. Prevalence of hypertension was positively associated with BMI. However, overweight men had as high prevalence of hypertension as the obese (multivariable-adjusted PR was 1.84 for overweight and 1.91 for obese compared with nonoverweight). The association between hypertension and BMI was similar across age groups. The prevalence of hypertension in women increased gradually with the increase of BMI whereas that in men reached a plateau already in the overweight.

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  126. Increased airway hyperresponsiveness to adenosine in patients with aspirin intolerant asthma Reviewed International journal

    Sumito Isogai, Yoshikazu Niwa, Hiroshi Yatsuya, Masamichi Hayashi, Naoki Yamamoto, Takuya Okamura, Tomoyuki Minezawa, Yasuhiro Goto, Teppei Yamaguchi, Tomoko Takeyama, Yosuke Sakakibara, Sayako Morikawa, Tomoya Horiguchi, Yusuke Gotoh, Yuki Mieno, Sakurako Uozu, Toru Nakanishi, Mitsushi Okazawa, Hiroki Sakakibara, Kazuyoshi Imaizumi

    ALLERGOLOGY INTERNATIONAL   Vol. 66 ( 2 ) page: 360 - 362   2017.4

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  127. Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers' Cohort Study Reviewed International journal

    Y. Zhang, H. Yatsuya, Y. Li, C. Chiang, Y. Hirakawa, N. Kawazoe, K. Tamakoshi, H. Toyoshima, A. Aoyama

    NUTRITION & DIABETES   Vol. 7 ( 3 )   2017.3

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    OBJECTIVE: This study aims to investigate the association of long-term weight-change slopes, weight fluctuation and the risk of type 2 diabetes mellitus (T2DM) in middle-aged Japanese men and women.
    METHODS: A total of 4234 participants of Aichi Workers' Cohort Study who were aged 35-66 years and free of diabetes in 2002 were followed through 2014. Past body weights at the ages of 20, 25, 30, 40 years, and 5 years before baseline as well as measured body weight at baseline were regressed on the ages. Slope and root-mean-square-error of the regression line were obtained and used to represent the weight changes and the weight fluctuation, respectively. The associations of the weight-change slopes and the weight fluctuation with incident T2DM were estimated by Cox proportional hazards models.
    RESULTS: During the median follow-up of 12.2 years, 400 incident cases of T2DM were documented. After adjustment for baseline overweight and other lifestyle covariates, the weight-change slopes were significantly associated with higher incidence of T2DM (hazard ratio (HR): 1.80, 95% confident interval (CI): 1.17-2.77 for men; and HR: 2.78, 95% CI: 1.07-7.23 for women), while the weight fluctuation was not (HR: 1.08, 95% CI: 1.00-1.18 for men and HR: 1.02, 95% CI: 0.84-1.25 for women).
    CONCLUSIONS: Regardless of the presence of overweight, the long-term weight-change slopes were significantly associated with the increased risk of T2DM; however, the weight fluctuation was not associated with the risk of T2DM in middle-aged Japanese men and women.

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  128. Daily Walking Time and Pneumonia Mortality Among Elderly With/Without Medical History of Myocardial Infarction or Stroke

    Ukawa Shigekazu, Zhao Wenjing, Yatsuya Hiroshi, Yamagishi Kazumasa, Iso Hiroyasu, Tamakoshi Akiko

    CIRCULATION   Vol. 135   2017.3

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  129. Daily Walking Time and Pneumonia Mortality Among Elderly With/Without Medical History of Myocardial Infarction or Stroke Reviewed

    Shigekazu Ukawa, Wenjing Zhao, Hiroshi Yatsuya, Kazumasa Yamagishi, Hiroyasu Iso, Akiko Tamakoshi

    CIRCULATION   Vol. 135   2017.3

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  130. Disparity in metabolic risk factors of non-communicable diseases between Palauans and Filipinos living in Palau Reviewed International coauthorship International journal

    Ayaka Osako, Chifa Chiang, Kana Ito, Hiroshi Yatsuya, Esayas Haregot Hilawe, Edolem Ikerdeu, Kaori Honjo, Takashi Mita, Renzhe Cui, Yoshihisa Hirakawa, Sherilynn Madraisau, Gregorio Ngirmang, Hiroyasu Iso, Atsuko Aoyama

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page: 157 - 165   2017.2

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    Non-communicable diseases have been recognized as a serious threat to public health in Palau. To tackle the problem, different strategies might be necessary for populations with different ethnic backgrounds. This study aims to find the differences in the prevalence of metabolic risk factors of non-communicable diseases between Palauans and Filipinos living in Palau, and examine possible determinants of the differences. We selected data of 2,032 participants, including native Palauans and Filipinos, from the Palau STEPS Survey 2011-2013 for this study. Logistic regression models were used to inspect the association of each metabolic risk factor with ethnicity by calculating odds ratios adjusted for potential confounding factors. Palauans had higher age-standardized prevalence of overweight or obesity (84% vs. 45%), hypertension (50% vs. 38%) and diabetes (19% vs. 13%) than Filipinos. However, after adjusting for BMI and various lifestyle related factors, there are no statistical significant differences in the prevalence of hypertension and diabetes between these two ethnic groups. Palauan men were less likely to have elevated total cholesterol, especially after adjusting for BMI (odds ratio=0.55, 95% confidence interval: 0.33-0.91), while Palauan women were more likely to have elevated triglycerides than their Filipino counterparts (odds ratio=1.45, 95% confidence interval: 1.02-2.06). Our findings suggested that Palauans' higher BMI distribution might be able to explain their higher prevalence of hypertension and partially explain their higher diabetes prevalence. Palauans were not consistently more likely to have all metabolic risk factors, namely dyslipidemia were less likely to be observed in Palauan men.

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  131. No modifying effect of education level on the association between lifestyle behaviors and cardiovascular mortality: the Japan Collaborative Cohort Study Reviewed International journal

    Eri Eguchi, Hiroyasu Iso, Kaori Honjo, Hiroshi Yatsuya, Akiko Tamakoshi

    SCIENTIFIC REPORTS   Vol. 7   page: 39820   2017.1

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    We examined the effect of education level on the association between healthy lifestyle behaviors and cardiovascular mortality in the Japanese population. A total of 42,647 community-based men and women aged 40-79 years were enrolled at baseline (1988-1990), followed through 2009. The components of the healthy lifestyle score included the intake of fruits, fish, and milk; body mass index; exercise; avoidance of smoking; moderate alcohol intake; and moderate sleep duration. During the 19.3 years of follow-up, 8,314 all-cause and 2,377 total cardiovascular mortality cases were noted. Inverse associations were observed between healthy lifestyle scores and total cardiovascular disease (CVD) for both the lower and higher education level groups. Multivariable hazard ratios (95% confidence interval) for CVD mortality from the highest to the lowest healthy lifestyle scores, and the population attributable fraction (95% CIs) without healthy lifestyle scores of 7-8 were 0.51 (0.33-0.52) and 42% (24-58%), and 0.38 (0.27-0.47) and 55% (36-69%) for the higher and lower education levels, respectively. Our findings suggest that the association between higher CVD mortality and lower education level can be explained by the individuals' lower adherence to a healthy lifestyle; hence, lifestyle modification would be beneficial for the prevention of cardiovascular mortality, irrespective of the education level.

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  132. Population profile and residential environment of an urban poor community in Dhaka, Bangladesh Reviewed International coauthorship International journal

    Md Khalequzzaman, Chifa Chiang, Bilqis Amin Hoque, Sohel Reza Choudhury, Saika Nizam, Hiroshi Yatsuya, Akiko Matsuyama, Yoshihisa Hirakawa, Syed Shariful Islam, Hiroyasu Iso, Atsuko Aoyama

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   Vol. 22 ( 1 ) page: 1   2017

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    Objectives: A population survey was conducted in an urban shantytown in Bangladesh, as a baseline study of future epidemiological studies. This paper aims to describe the findings of the study, including the population profile and residential environment of the urban poor.
    Methods: We conducted a complete count household survey in an urban poor community in Dhaka. Using a brief structured questionnaire in Bengali language, trained interviewers visited each household and asked questions such as: duration of residence; ownership of house, toilet and kitchen; water supply; number of family members; age, sex, education, occupation, tobacco use, and history of diseases of each family member.
    Results: We found that there were 8604 households and 34,170 people in the community. Average number of household members was 4.0. Most people had access to safe water, but only 16% lived in the house with a toilet. Based on the proxy indicators of household wealth levels, we identified that about 39% were relatively well-off, while the rest were very poor. Tobacco use was prevalent in men regardless of age and in women aged over 35 years. Prevalence of self-reported hypertension and diabetes was slightly higher in women than in men, although over 70% of the respondents didn't know if they had such diseases. Incidences of diarrhea in the last one month were relatively low.
    Conclusions: The study showed population profile and sanitation environment in an urban poor community by a complete count survey. We expect the study to serve as a baseline for future epidemiological studies.

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  133. Risk Factor of Cardiovascular Disease Among Older Individuals Reviewed International journal

    Hiroshi Yatsuya, Masaaki Matsunaga, Yuanying Li, Atsuhiko Ota

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   Vol. 24 ( 3 ) page: 258 - 261   2017

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  134. Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN) Reviewed

    Yoichiro Hirakawa, the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN), Toshiharu Ninomiya, Yutaka Kiyohara, Yoshitaka Murakami, Shigeyuki Saitoh, Hideaki Nakagawa, Akira Okayama, Akiko Tamakoshi, Kiyomi Sakata, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Takeo Nakayama, Toshimi Sairenchi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya

    Journal of Epidemiology   Vol. 27 ( 3 ) page: 123 - 129   2017

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    Background: Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations. Methods: A pooled analysis was conducted using 8 cohort studies (mean follow-up period, 10.3 years) in Japan, combining the data from 38,854 individual participants without history of cardiovascular disease. In all, 1867 of the participants had diabetes, defined based on the 1998 World Health Organization criteria. The association between diabetes and the risk of death from cardiovascular disease, coronary heart disease (CHD), and stroke was estimated using a stratified Cox model, accounting for variability of baseline hazard functions among cohorts. Results: During the follow-up, 1376 subjects died of cardiovascular disease (including 268 of coronary heart disease and 621 of stroke). Diabetes was associated with an increased risk of cardiovascular death after multivariable adjustment (hazard ratio [HR] 1.62
    95% confidence interval [CI], 1.35-1.94). Similarly, diabetes was a risk factor for CHD (HR 2.13
    95% CI, 1.47-3.09) and stroke (HR 1.40
    95% CI, 1.05-1.85). In the age-stratified analysis of the risk of cardiovascular death, the relative effects of diabetes were consistent across age groups (p for heterogeneity = 0.18), whereas the excess absolute risks of diabetes were greater in participants in their 70s and 80s than in younger subjects. Conclusions: The management of diabetes is important to reduce the risk of death from cardiovascular disease, not only in midlife but also in late life, in the Japanese population.

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  135. Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study Reviewed

    Yamagishi K, Iso H, Yatsuya H, Tanabe N, Date C, Kikuchi S, Yamamoto A, Inaba Y, Tamakoshi A; JACC Study Group.

    Am J Clin Nutr   Vol. 92 ( 4 ) page: 759-765   2010.10

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  136. Sex-Specific HDL Cholesterol Changes With Weight Loss and Their Association With Anthropometric Variables: The LIFE Study Reviewed

    Yatsuya H, Jeffery RW, Erickson DJ, Welsh EM, Flood AP, Jaeb MA, Laqua PS, Mitchell NR, Langer SL, Levy RL

    Obesity (Silver Spring)   Vol. Epub   2010.9

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  137. Associations of obesity measures with subtypes of ischemic stroke in the ARIC Study.

    Yatsuya H, Yamagishi K, North KE, Brancati FL, Stevens J, Folsom AR; ARIC Study Investigators.

    J Epidemiol   Vol. 20 ( 5 ) page: 347-354   2010.9

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  138. Risk of incident cardiovascular disease among users of smokeless tobacco in the Atherosclerosis Risk in Communities (ARIC) study. Reviewed

    Yatsuya H, Folsom AR; ARIC Investigators.

    Am J Epidemiol   Vol. 172 ( 5 ) page: 600-605   2010.9

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  139. Body mass index and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanese cohorts using individual data. Reviewed

    Yatsuya H, Toyoshima H, Yamagishi K, Tamakoshi K, Taguri M, Harada A, Ohashi Y, Kita Y, Naito Y, Yamada M, Tanabe N, Iso H, Ueshima H; Japan Arteriosclerosis Longitudinal Study (JALS) group.

    Circ Cardiovasc Qual Outcomes.   Vol. 3 ( 5 ) page: 498-505   2010.9

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  140. Maintenance-tailored therapy vs. standard behavior therapy for 30-month maintenance of weight loss. Reviewed

    Levy RL, Jeffery RW, Langer SL, Graham DJ, Welsh EM, Flood AP, Jaeb MA, Laqua PS, Finch EA, Hotop AM, Yatsuya H.

    Prev Med   Vol. Epub   2010.9

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  141. Incidence of metabolic syndrome according to combinations of lifestyle factors among middle-aged Japanese male workers. Reviewed

    Li Y, Yatsuya H, Iso H, Tamakoshi K, Toyoshima H.

    Prev Med   Vol. 51 ( 2 ) page: 118-122   2010.8

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  142. Retinal microvascular abnormalities and risk of lacunar stroke: Atherosclerosis Risk in Communities Study Reviewed

    Yatsuya H, Folsom AR, Wong TY, Klein R, Klein BE, Sharrett AR; ARIC Study Investigators.

    Stroke   Vol. 41 ( 7 ) page: 1349-1355   2010.7

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  143. Demographic and cardiovascular risk factors modify association of fasting insulin with incident coronary heart disease and ischemic stroke (from the Atherosclerosis Risk In Communities Study). Reviewed

    Rasmussen-Torvik LJ, Yatsuya H, Selvin E, Alonso A, Folsom AR.

    Am J Cardiol   Vol. 105 ( 10 ) page: 1420-1425   2010.5

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  144. Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. Reviewed

    Muramatsu T, Yatsuya H, Toyoshima H, Sasaki S, Li Y, Otsuka R, Wada K, Hotta Y, Mitsuhashi H, Matsushita K, Murohara T, Tamakoshi K.

    Prev Med.   Vol. 50 ( 5-6 ) page: 272-276   2010.5

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  145. Race- and Sex-Specific Associations of Obesity Measures With Ischemic Stroke Incidence in the Atherosclerosis Risk in Communities (ARIC) Study Reviewed

    Yatsuya H, Folsom AR, Yamagishi K, North KE, Brancati FL, Stevens J; for the ARIC Study Investigators

    Stroke   Vol. 41 ( 3 ) page: 417-425   2010.3

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    BACKGROUND AND PURPOSE: Studies have suggested differences in the association between obesity and ischemic stroke in black versus white populations. In this study, we explored ischemic stroke risk in relation to a variety of obesity measures by sex and race. METHODS: Using data from the Atherosclerosis Risk in Communities Study, we obtained information on body mass index, waist circumference, and waist-to-hip ratio from 13 549 black and white participants who were aged 45 to 65 years between 1987 and 1989. All were free of cardiovascular disease and cancer at baseline. Incident strokes over a median follow-up of 16.9 years were ascertained from hospital records. RESULTS: Although crude incidence rates of ischemic stroke varied more than 3-fold by race and sex, the relationship between higher measures of obesity and ischemic stroke risk was positive and linear across all groups. The crude incidence of ischemic stroke was 1.2 per 1000 person-years for white women with the lowest body mass index, ranging up to 8.0 per 1000 person-years for black men with the highest body mass index. Hazard ratios for the highest versus lowest quintile of body mass index, waist circumference, and waist-to-hip ratio ranged from 1.43 to 3.19, indicating increased stroke risk associated with obesity, however it was measured, even after adjustment for potential confounders. Additional adjustment for factors that may mediate the relationship, such as diabetes and hypertension, significantly attenuated the associations, suggesting that these factors may explain much of the stroke risk associated with obesity. CONCLUSIONS: Degree of obesity, defined by body mass index, waist circumference, or waist-to-hip ratio, was a significant risk factor for ischemic stroke regardless of sex or race.

  146. Daytime napping and mortality, with a special reference to cardiovascular disease: the JACC study Reviewed

    Tanabe N, Iso H, Seki N, Suzuki H, Yatsuya H, Toyoshima H, Tamakoshi A; for the JACC Study Group

    Int J Epidemiol   Vol. 39 ( 1 ) page: 233-243   2010.2

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  147. BMI and all-cause mortality among Japanese older adults: findings from the Japan collaborative cohort study. Reviewed

    Tamakoshi A, Yatsuya H, Lin Y, Tamakoshi K, Kondo T, Suzuki S, Yagyu K, Kikuchi S; JACC Study Group

    Obesity (Silver Spring)   Vol. 18 ( 2 ) page: 362-369   2010.2

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  148. Vaginal douching in Cambodian women: its prevalence and association with vaginal candidiasis Reviewed

    Heng LS, Yatsuya H, Morita S, Sakamoto J

    J Epidemiol   Vol. 20 ( 1 ) page: 70-76   2010

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  149. Changes in C-reactive protein during weight loss and the association with changes in anthropometric variables in men and women: LIFE Study. Reviewed

    Yatsuya H, Jeffery RW, Langer SL, Mitchell N, Flood AP, Welsh EM, Jaeb MA, Laqua PS, Crowell M, Levy RL

    Int J Obes (Lond).   Vol. Epub   2010

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  150. Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2. Reviewed

    Ito E, Saito K, Yatsuya H, Nagatani T, Otsuka G

    Neurosurg Rev   Vol. 32 ( 4 ) page: 425-433   2009.10

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  151. Changes in activities of dail living, physical fitness, and depressive symptoms after six-month periodic well-rounded exercise programs for older adults living in nursing homes or special nursing facilities Reviewed

    Ouyang P, Yatsuya H, Toyoshima H, Otsuka R, Wada K, Matsushita K, Ishikawa M, Lee Y, Hotta Y, Mitsuhashi H, Muramatsu T, Kasuga N, Tamakoshi K

    Nagoya J Med Sci   Vol. 71 ( 3-4 ) page: 115-126   2009.9

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  152. Multilevel analyses of effects of variation in body mass index on serum lipid concentrations in middle-aged Japanese men. Reviewed

    Kondo T, Kimata A, Yamamoto K, Ueyama S, Ueyama J, Yatsuya H, Tamakoshi K, Hori Y

    Nagoya J Med Sci   Vol. 71 ( 1-2 ) page: 19-28   2009.2

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  153. Upper airway morphology in patients with obstructive sleep apnea syndrome: Effects of lateral positioning. Reviewed

    Soga T, Nakata S, Yasuma F, Noda A, Sugiura T, Yatsuya H, Koike Y, Ozaki N, Nakashima T.

    Auris Nasus Larynx   Vol. 36 ( 3 ) page: 305-309   2009.1

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  154. An influence of Interferon-gamma gene polymorphisms on treatment response to tuberculosis in Japanese population. Reviewed

    Shibasaki M, Yagi T, Yatsuya H, Okamoto M, Nishikawa M, Baba H, Hashimoto N, Senda K, Kawabe T, Nakashima K, Imaizumi K, Shimokata K, Hasegawa Y

    J Infect   Vol. 58 ( 6 ) page: 467-469   2009.1

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  155. Group education with personal rehabilitation for idiopathic Parkinson's disease. Reviewed

    Guo L, Jiang Y, Yatsuya H, Yoshida Y, Sakamoto J.

    Can J Neurol Sci   Vol. 36 ( 1 ) page: 51-59   2009

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  156. Effect of the interaction between mental stress and eating pattern on body mass index gain in healthy Japanese male workers. Reviewed

    Toyoshima H, Masuoka N, Hashimoto S, Otsuka R, Sasaki S, Tamakoshi K, Yatsuya H.

    J Epidemiol   Vol. 19 ( 2 ) page: 88-93   2009

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  157. Uric Acid and left ventricular hypertrophy in Japanese men. Reviewed

    Mitsuhashi H, Yatsuya H, Matsushita K, Zhang H, Otsuka R, Muramatsu T, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H, Tamakoshi K.

    Circ J   Vol. 73 ( 4 ) page: 667-672   2009

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  158. Effect of physical activity on breast cancer risk: findings of the Japan collaborative cohort study. Reviewed

    Suzuki S, Kojima M, Tokudome S, Mori M, Sakauchi F, Fujino Y, Wakai K, Lin Y, Kikuchi S, Tamakoshi K, Yatsuya H, Tamakoshi A; Japan Collaborative Cohort Study Group.

    Cancer Epidemiol Biomarkers Prev   Vol. 17 ( 12 ) page: 3396-3401   2008

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  159. Development and validity of the Japanese version of body shape silhouette: relationship between self-rating silhouette and measured body mass index. Reviewed

    Nagasaka K, Tamakoshi K, Matsushita K, Toyoshima H, Yatsuya H.

    Nagoya J Med Sci   Vol. 70 ( 3-4 ) page: 89-96   2008

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  160. Self-reported medical history was generally accurate among Japanese workplace population. Reviewed

    Wada K, Yatsuya H, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Tamakoshi K.

    J Clin Epidemiol   Vol. 62 ( 3 ) page: 306-313   2008

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  161. Having more healthy practice was associated with low white blood cell counts in middle-aged Japanese male and female workers. Reviewed

    Otsuka R, Tamakoshi K, Wada K, Matsushita K, Ouyang P, Hotta Y, Takefuji S, Mitsuhashi H, Toyoshima H, Shimokata H, Yatsuya H.

    Ind Health   Vol. 46 ( 4 ) page: 341-347   2008

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  162. TH1/TH2 immune response in lung fibroblasts in interstitial lung disease. Reviewed

    Sumida A, Hasegawa Y, Okamoto M, Hashimoto N, Imaizumi K, Yatsuya H, Yokoi T, Takagi K, Shimokata K, Kawabe T.

    Arch Med Res   Vol. 39 ( 5 ) page: 503-510   2008

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  163. Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: comparison of leptin and adiponectin. Reviewed

    Sugiura K, Tamakoshi K, Yatsuya H, Otsuka R, Wada K, Matsushita K, Kondo T, Hotta Y, Mitsuhashi H, Murohara T, Toyoshima H.

    Int J Cardiol   Vol. 130 ( 2 ) page: 159-164   2008

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  164. Further inflammatory information on metabolic syndrome by adiponectin evaluation. Reviewed

    Int J Cardiol   Vol. 124 ( 3 ) page: 339-344   2008

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  165. Low leptin but high insulin resistance of smokers in Japanese men. Reviewed

    Hotta Y, Yatsuya H, Toyoshima H, Matsushita K, Mitsuhashi H, Takefuji S, Oiso Y, Tamakoshi K.

    Diabetes Res Clin Pract   Vol. 81 ( 3 ) page: 358-364   2008

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    We investigated the association between smoking and leptin, and to discuss their influence on diabetes in a large-scale study of Japanese men. METHODS: A cross-sectional study was carried out in 2002. The subjects were 2836 men aged 35-66. Smoking history was investigated in a self-administered questionnaire. Blood leptin, glucose and insulin were measured. RESULTS: Significant differences in leptin levels and homeostasis model assessment of insulin resistance (HOMA-IR) related to smoking status were observed (P=0.001 and P=0.008, respectively). The multivariate-adjusted geometric means of leptin in current, past and never smokers were 3.88, 4.08 and 4.12 ng/ml, respectively, while the means of HOMA-IR were 1.64, 1.61 and 1.49, respectively. The age-, body mass index-, and other lifestyle-adjusted prevalences of diabetes in current and never smokers were 9.2 and 4.7%, respectively. That of current smokers was significantly higher than in never smokers (P<0.001). The dose-dependent association found between the intensity of smoking and leptin levels in current smokers was statistically significant (P=0.030). CONCLUSIONS: The present finding may explain in part an association among smoking, leptin levels and diabetes. Smoking is one of the important modifiable risk factors for the prevention of diabetes.

  166. Association between low birth weight and elevated white blood cell count in adulthood within a Japanese population. Reviewed

    Wada K, Tamakoshi K, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Yatsuya H.

    Circ J   Vol. 72 ( 5 ) page: 757-763   2008

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  167. Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Reviewed

    Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Mori M, Tamakoshi A; Japan Collaborative Cohort Study Group for Evaluation of Cancer Risk.

    J Epidemiol   Vol. 18 ( 2 ) page: 77-83   2008

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  168. Eating fast leads to insulin resistance: findings in middle-aged Japanese men and women. Reviewed

    Otsuka R, Tamakoshi K, Yatsuya H, Wada K, Matsushita K, OuYang P, Hotta Y, Takefuji S, Mitsuhashi H, Sugiura K, Sasaki S, Kral JG, Toyoshima H.

    Prev Med   Vol. 46 ( 2 ) page: 154-159   2008

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  169. Smoking status and adiponectin in healthy Japanese men and women. Reviewed

    Takefuji S, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Matsushita K, Sugiura K, Hotta Y, Mitsuhashi H, Oiso Y, Toyoshima H.

    Prev Med   Vol. 45 ( 6 ) page: 471-475   2007.12

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  170. High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Yang PO, Otsuka R, Wada K, Mitsuhashi H, Hotta Y, Kondo T, Murohara T, Toyoshima H.

    Circ J   Vol. 71 ( 6 ) page: 820-825   2007

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  171. A new method of blood sampling reduces pain for newborn infants: a prospective, randomized controlled clinical trial. Reviewed

    Sato Y, Fukasawa T, Hayakawa M, Yatsuya H, Hatakeyama M, Ogawa A, Kuno K.

    Early Hum Dev   Vol. 83 ( 6 ) page: 389-394   2007

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  172. The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin-resistant state. Reviewed

    Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Yang PO, Sugiura K, Hotta Y, Mitsuhashi H, Takefuji S, Kondo T, Toyoshima H.

    Clin Endocrinol (Oxf)   Vol. 66 ( 1 ) page: 65-71   2007

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  173. Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study). Reviewed

    Kondo T, Hori Y, Yatsuya H, Tamakoshi K, Toyoshima H, Nishino Y, Seki N, Ito Y, Suzuki K, Ozasa K, Watanabe Y, Ando M, Wakai K, Tamakoshi A.

    Cancer Causes Control   Vol. 18 ( 2 ) page: 229-234   2007

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  174. Psychological attitudes and risk of breast cancer in Japan: a prospective study. Reviewed

    Wakai K, Kojima M, Nishio K, Suzuki S, Niwa Y, Lin Y, Kondo T, Yatsuya H, Tamakoshi K, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; for the JACC Study Group.

    Cancer Causes Control   Vol. 18 ( 3 ) page: 259-267   2007

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  175. Psychological factors and insomnia among male civil servants in Japan. Reviewed

    Murata C, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Toyoshima H.

    Sleep Med   Vol. 8 ( 3 ) page: 209-217   2007

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  176. A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3. Reviewed

    Pham TM, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Matsuda S, Yoshimura T; The JACC Study Group.

    Eur J Cancer   Vol. 43 ( 10 ) page: 1611-1616   2007

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  177. Impact of intensive-care-unit(ICU)-acquired ventilator-associated pneumonia(VAP) on hospital mortality: a matched-paired case-control study. Reviewed

    Uno H, Takezawa J, Yatsuya H, Suka M, Yoshida K.

    Nagoya J Med Sci   Vol. 69 ( 1-2 ) page: 29-36   2007

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  178. White blood cell count and risk of all-cause and cardiovascular mortality in nationwide sample of Japanese--results from the NIPPON DATA90. Reviewed

    Tamakoshi K, Toyoshima H, Yatsuya H, Matsushita K, Okamura T, Hayakawa T, Okayama A, Ueshima H; NIPPON DATA90 Research Group.

    Circ J   Vol. 71 ( 4 ) page: 479-485   2007

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  179. Adiponectin level and left ventricular hypertrophy in Japanese men. Reviewed

    Mitsuhashi H, Yatsuya H, Tamakoshi K, Matsushita K, Otsuka R, Wada K, Sugiura K, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H.

    Hypertension   Vol. 49 ( 6 ) page: 1448-1454   2007

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  180. A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3. Reviewed

    Pham TM, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Matsuda S, Yoshimura T; JACC Study Group.

    Eur J Cancer   Vol. 43 ( 10 ) page: 1611-1616   2007

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  181. Risk factors for first acute myocardial infarction attack assessed by cardiovascular disease registry data in Aichi Prefecture. Reviewed

    Kondo Y, Toyoshima H, Yatsuya H, Hirose K, Morikawa Y, Ikedo N, Masui T, Tamakoshi K.

    Nagoya J Med Sci   Vol. 69 ( 3-4 ) page: 139-147   2007

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  182. A nested case-control study of stomach cancer incidence and serum superoxide dismutase activity in the Japan Collaborative Cohort study in Japan. Reviewed

    Pham TM, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Kubo T, Matsuda S, Yoshimura T; JACC Study Group.

    Cancer Detect Prev   Vol. 31 ( 6 ) page: 431-435   2007

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  183. Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities. Reviewed

    Ichihara M, Murakumo Y, Masuda A, Matsuura T, Asai N, Jijiwa M, Ishida M, Shinmi J, Yatsuya H, Qiao S, Takahashi M, Ohno K.

    Nucleic Acids Res   Vol. 35 ( 18 ) page: e123   2007

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  184. Pathophysiologic mechanisms of obesity and related metabolic disorders: an epidemiologic study using questionnaire and serologic biomarkers. Invited

    Yatsuya H.

    J Epidemiol   Vol. 17 ( 5 ) page: 141-146   2007

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  185. Reduction of inner retinal thickness in patients with autosomal dominant optic atrophy associated with OPA1 mutations. Reviewed

    Ito Y, Nakamura M, Yamakoshi T, Lin J, Yatsuya H, Terasaki H.

    Invest Ophthalmol Vis Sci   Vol. 48 ( 9 ) page: 4079-4086   2007

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  186. Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients. Reviewed

    Nihashi T, Yatsuya H, Hayasaka K, Kato R, Kawatsu S, Arahata Y, Iwai K, Takeda A, Washimi Y, Yoshimura K, Mizuno K, Kato T, Naganawa S, Ito K.

    Radiat Med   Vol. 25 ( 6 ) page: 255-262   2007

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  187. Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study. Reviewed

    Nishio K, Niwa Y, Toyoshima H, Tamakoshi K, Kondo T, Yatsuya H, Yamamoto A, Suzuki S, Tokudome S, Lin Y, Wakai K, Hamajima N, Tamakoshi A.

    Cancer Causes Control   Vol. 18 ( 8 ) page: 801-808   2007

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  188. High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Yang PO, Otsuka R, Wada K, Mitsuhashi H, Hotta Y, Kondo T, Murohara T, Toyoshima H.

      Vol. 71 ( 6 ) page: 820-825   2007

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  189. Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Zhang H, Sugiura K, Kondo T, Murohara T, Toyoshima H.

    Atherosclerosis   Vol. 188   page: 184-189   2006.9

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  190. Perceived psychological stress and serum leptin concentrations in Japanese men. Reviewed

    Otsuka R, Yatsuya H, Tamakoshi K, Matsushita K, Wada K, Toyoshima H.

    Obesity (Silver Spring)   Vol. 14 ( 10 ) page: 1832-1838   2006

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  191. Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Takefuji S, Sugiura K, Kondo T, Murohara T, Toyoshima H.

    Arterioscler Thromb Vasc Biol   Vol. 26 ( 4 ) page: 871-876   2006

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  192. Birth weight and adult hypertension: cross-sectional study in a Japanese workplace population. Reviewed

    Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Yang PO, Sugiura K, Hotta Y, Mitsuhashi H, Kondo T, Toyoshima H.

    Circ J   Vol. 70 ( 3 ) page: 262-267   2006

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  193. Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring. Reviewed

    Wada K, Tamakoshi K, Yatsuya H, Otsuka R, Murata C, Zhang H, Takefuji S, Matsushita K, Sugiura K, Toyoshima H.

    Prev Med   Vol. 42 ( 5 ) page: 358-363   2006

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  194. Determinants of self-rated health: could health status explain the association between self-rated health and mortality? Reviewed

    Murata C, Kondo T, Tamakoshi K, Yatsuya H, Toyoshima H.

    Arch Gerontol Geriatr   Vol. 43 ( 3 ) page: 369-380   2006

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  195. Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren. Reviewed

    Fujii C, Sakakibara H, Kondo T, Yatsuya H, Tamakoshi K, Toyoshima H.

    J Epidemiol   Vol. 16 ( 2 ) page: 64-70   2006

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  196. Low birth weight is associated with reduced adiponectin concentration in adult. Reviewed

    Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Sugiura K, Kondo T, Toyoshima H.

    Ann Epidemiol   Vol. 16 ( 9 ) page: 669-674   2006

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  197. Eating fast leads to obesity: findings based on self-administered questionnaires among middle-aged Japanese men and women. Reviewed

    Otsuka R, Tamakoshi K, Yatsuya H, Murata C, Sekiya A, Wada K, Zhang HM, Matsushita K, Sugiura K, Takefuji S, OuYang P, Nagasawa N, Kondo T, Sasaki S, Toyoshima H.

    Journal of Epidemiology   Vol. 16 ( 3 ) page: 117-124   2006

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  198. Factors associated with life space among community-living rural elders in Japan. Reviewed

    Murata C, Kondo T, Tamakoshi K, Yatsuya H, Toyoshima H.

    Public Health Nurs   Vol. 23 ( 4 ) page: 324-331   2006

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  199. Interleukin-8 gene polymorphism associated with susceptibility to non-cardia gastric carcinoma with microsatellite instability. Reviewed

    Shirai K, Ohmiya N, Taguchi A, Mabuchi N, Yatsuya H, Itoh A, Hirooka Y, Niwa Y, Mori N, Goto H.

    J Gastroenterol Hepatol   Vol. 21 ( 7 ) page: 1129-1135   2006

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  200. Seasonal variations of acute massive submacular haemorrhage associated with age-related macular degeneration. Reviewed

    Iguchi Y, Ito Y, Kikuchi M, Ishikawa K, Oshima H, Yatsuya H, Terasaki H.

    Br J Ophthalmol   Vol. 90 ( 10 ) page: 1256-1258   2006

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  201. Factors related to frequency of engaging in outside activities among elderly persons living an independent life at home. Reviewed

    Ishikawa M, Tamakoshi K, Yatsuya H, Suma K, Wada K, Otsuka R, Matsushita K, Zhang H, Murata C, Kondo T, Toyoshima H.

    Nagoya J Med Sci   Vol. 68 ( 3-4 ) page: 121-130   2006

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  202. HIV prevalence and factors associated with HIV infection among male injection drug users under 30: a cross-sectional study in Long An, Vietnam. Reviewed

    Tran TM, Nguyen HT, Yatsuya H, Hamajima N, Nishimura A, Ito K.

    BMC Public Health   Vol. 10 ( 6 ) page: 248   2006

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  203. A positive association between leptin and blood pressure of normal range in Japanese men. Reviewed

    Wada K, Yatsuya H, Tamakoshi K, Otsukai R, Fujii C, Matsushita K, Sugiura K, Toyoshima H.

    Hypertens Res   Vol. 29 ( 7 ) page: 485-492   2006

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  204. Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Zhang H, Sugiura K, Kondo T, Murohara T, Toyoshima H.

    Atherosclerosis   Vol. 188 ( 1 ) page: 184-189   2006

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  205. Familial aggregation and coaggregation of history of hypertension and stroke. Reviewed

    Kondo T, Toyoshima H, Tsuzuki Y, Hori Y, Yatsuya H, Tamakoshi K, Tamakoshi A, Ohno Y; JACC Study Group.

    J Hum Hypertens   Vol. 19 ( 2 ) page: 119-25   2005

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  206. Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men. Reviewed

    Zhang H, Tamakoshi K, Yatsuya H, Murata C, Wada K, Otsuka R, Nagasawa N, Ishikawa M, Sugiura K, Matsushita K, Hori Y, Kondo T, Toyoshima H.

    Circ J   Vol. 69 ( 1 ) page: 13-8   2005

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  207. Impact of menstrual and reproductive factors on breast cancer risk in Japan: results of the JACC study. Reviewed

    Tamakoshi K, Yatsuya H, Wakai K, Suzuki S, Nishio K, Lin Y, Niwa Y, Kondo T, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; JACC Study Group.

    Cancer Sci   Vol. 96 ( 1 ) page: 57-62   2005

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  208. Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women. Reviewed

    Mabuchi T, Yatsuya H, Tamakoshi K, Otsuka R, Nagasawa N, Zhang H, Murata C, Wada K, Ishikawa M, Hori Y, Kondo T, Hashimoto S, Toyoshima H.

    Diabetes Metab Res Rev   Vol. 21 ( 5 ) page: 441-7   2005

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  209. Cigarette smoking and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort study. Reviewed

    Niwa Y, Wakai K, Suzuki S, Tamakoshi K, Lin Y, Yatsuya H, Kondo T, Nishio K, Yamamoto A, Tokudome S, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

    J Obstet Gynaecol Res   Vol. 31 ( 2 ) page: 144-51   2005

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  210. Prospective study of alcohol consumption and breast cancer risk in Japanese women. Reviewed

    Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A.

    Int J Cancer   Vol. 116 ( 5 ) page: 779-83   2005

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  211. Validity of self-reported height and weight in a Japanese workplace population. Reviewed

    Wada K, Tamakoshi K, Tsunekawa T, Otsuka R, Zhang H, Murata C, Nagasawa N, Matsushita K, Sugiura K, Yatsuya H, Toyoshima H.

    Int J Obes Relat Metab Disord   Vol. 29 ( 9 ) page: 1093-9   2005

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  212. Effects of social relationships on mortality among the elderly in a Japanese rural area: an 88-month follow-up study. Reviewed

    Murata C, Takaaki K, Hori Y, Miyao D, Tamakoshi K, Yatsuya H, Sakakibara H, Toyoshima H.

    J Epidemiol   Vol. 15 ( 3 ) page: 78-84   2005

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  213. Gender difference of sudden death Invited

    Tamakoshi K, Toyoshima H, Yatsuya H.

    Nippon Rinsho   Vol. 63 ( 7 ) page: 1284-8   2005

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  214. Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan. Reviewed

    Tamakoshi K, Toyoshima H, Wakai K, Kojima M, Suzuki K, Watanabe Y, Hayakawa N, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A.

    Oncology   Vol. 68 ( 4-6 ) page: 454-61   2005

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  215. Green tea and stomach cancer--a short review of prospective studies. Reviewed

    Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Yoshimura T; JACC Study Group.

    J Epidemiol   Vol. 15 ( S2 ) page: S109-12   2005

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  216. Cigarette smoking and mortality due to stomach cancer: findings from the JACC Study. Reviewed

    Fujino Y, Mizoue T, Tokui N, Kikuchi S, Hoshiyama Y, Toyoshima H, Yatsuya H, Sakata K, Tamakoshi A, Ide R, Kubo T, Yoshimura T; JACC Study Group.

    J Epidemiol   Vol. 15 ( S2 ) page: S113-S119   2005

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  217. Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study. Reviewed

    Kikuchi S, Yagyu K, Obata Y, Yingsong L, Yatsuya H, Hoshiyama Y, Kondo T, Sakata K, Mizoue T, Tokui N, Fujino Y, Tamakoshi A, Toyoshima H, Ishibashi T, Hayakawa N, Yoshimura T; JACC Study Group.

    J Epidemiol   Vol. 15 ( S2 ) page: S126-S133   2005

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  218. Mortality and incidence rates of stomach cancer in the JACC Study. Reviewed

    J Epidemiol   Vol. 15 ( S2 ) page: S89-S97   2005

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  219. Dietary habits and stomach cancer risk in the JACC Study. Reviewed

    Tokui N, Yoshimura T, Fujino Y, Mizoue T, Hoshiyama Y, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Kubo T, Tamakoshi A; JACC Study Group.

    J Epidemiol   Vol. 15 ( S2 ) page: S98-S108   2005

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  220. Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Reviewed

    Wakai K, Tamakoshi K, Date C, Fukui M, Suzuki S, Lin Y, Niwa Y, Nishio K, Yatsuya H, Kondo T, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A; JACC Study Group.

    Cancer Sci   Vol. 96 ( 9 ) page: 590-599   2005

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  221. Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. Reviewed

    Niwa Y, Yatsuya H, Tamakoshi K, Nishio K, Kondo T, Lin Y, Suzuki S, Wakai K, Tokudome S, Yamamoto A, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

    J Obstet Gynaecol Res   Vol. 31 ( 5 ) page: 452-458   2005

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  222. Serum levels of insulin-like growth factor I, II, and binding protein 3, transforming growth factor beta-1, soluble fas ligand and superoxide dismutase activity in stomach cancer cases and their controls in the JACC Study. Reviewed

    Yatsuya H, Toyoshima H, Tamakoshi K, Tamakoshi A, Kondo T, Hayakawa N, Sakata K, Kikuchi S, Hoshiyama Y, Fujino Y, Mizoue T, Tokui N, Yoshimura T; JACC Study Group.

    Journal of Epidemiology   Vol. 15 ( S2 ) page: S120-S125   2005

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    BACKGROUND: The prognosis of stomach cancer with advanced stage remains poor. New biomarkers of the disease that may contribute to establish the potential screening strategy would be of value for the early detection of individuals at high risk of the disease. METHODS: We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the Japan Collaborative Cohort (JACC) Study, to evaluate serum levels of insulin-like growth factor I, II, and binding protein 3 (IFG-I, IGF-II, and IGFBP-3), transforming growth factorbeta-1 (TGFbeta1), soluble fas (sFas) and superoxide dismutase activity (SOD) in 210 stomach cancer cases diagnosed in the JACC Study in relation to those levels in their 410 controls. RESULTS: Among 6 serum biomarkers tested for case-control differences, only sFas level in female stomach cancer cases was significantly higher than that of controls (2.22 pg/ml vs. 2.04 pg/mL, respectively; P=0.013 by two-way analysis of covariance controlling for matching variable). CONCLUSION: None of the biomarkers consistently predicted future risk of stomach cancer in both men and women in the present analysis. Serum sFas level in women, however, should be studied much more thoroughly whether it provides meaningful refinement of risk stratification, or it elucidate the mechanisms of tumorigenesis in women.

  223. Lack of an association between serum level of transforming growth factor beta -1 and stomach cancer risk in the JACC study.

    Yatsuya H, Tamakoshi A, Tamakoshi K, Hoshiyama Y, Fujino Y, Tokui N, Mizoue T, Kikuchi S, Sakata K, Hayakawa N, Kondo T, Toyoshima H, Yoshimura T.

    Asian Pacific Journal of Cancer Prevention   Vol. 6 ( 2 ) page: 170-176   2005

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    Alterations in the serum concentration of transforming growth factor beta-1 (TGFbeta1) have been observed in gastric cancer patients. No study, however, has ever examined the association between the serum TGFbeta1 level and stomach cancer prospectively. We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the JACC Study to assess whether serum level of total TGFbeta1 is associated with a subsequent risk of stomach cancer. The concentration of serum TGFbeta1 in previously collected blood samples was analyzed by ELISA for 209 individuals in whom a diagnosis of stomach cancer was documented, and for 409 controls matched with them for gender, age and study area. Baseline blood levels of TGFbeta1 were not related to the risk of stomach cancer in either men or women, a finding unchanged even after adjustment for potential confounders. The multivariate-adjusted odds ratio of stomach cancer in men and women was 1.10 (95% CI, 0.82 to 1.48) and 1.09 (95% CI, 0.80 to 1.48), respectively, for each increase of 1 SD in the TGFbeta1 value. In conclusion, serum TGFbeta1 levels were not associated with increased risks of subsequent stomach cancer.

  224. 出生時体重と成人期の生活習慣病との関連-胎児期起源仮説- Invited

    玉腰浩司、八谷寛、大塚礼、和田恵子、張恵明、豊嶋英明.

    現代医学   Vol. 52   page: 321-325   2005

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  225. 突然死と性差 Invited

    玉腰浩司、豊嶋英明、八谷寛.

    日本臨床   Vol. 63   page: 1284-1288   2005

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  226. 肥満の健康影響 Invited

    八谷寛、玉腰浩司、豊嶋英明.

    現代医学   Vol. 52   page: 521-526   2005

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  227. 肥満の科学的解明とエビデンスに基づいた対策・指導 Invited

    八谷寛、松下邦洋、玉腰浩司、大塚礼、和田恵子、豊嶋英明.

    産業医学レビュー   Vol. 18   page: 71-116   2005

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  228. 職域コホート男性における血清レプチン濃度と生活習慣との関連 Reviewed

      Vol. 63   page: 1284-1288   2005

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  229. Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. Reviewed

    Niwa Y, Yatsuya H, Tamakoshi K, Nishio K, Kondo T, Lin Y, Suzuki S, Wakai K, Tokudome S, Yamamoto A, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

    J Obstet Gynaecol Res   Vol. 31 ( 5 ) page: 452-458   2005

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  230. Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Reviewed

    Wakai K, Tamakoshi K, Date C, Fukui M, Suzuki S, Lin Y, Niwa Y, Nishio K, Yatsuya H, Kondo T, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A; JACC Study Group.

    Cancer Sci   Vol. 96 ( 9 ) page: 590-599   2005

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  231. A nested case-control study of stomach cancer in relation to green tea consumption in Japan. Reviewed

    Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T; Japan Collaborative Cohort Study Group.

    Br J Cancer   Vol. 90 ( 1 ) page: 135-8   2004

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  232. A prospective study of body size and colon cancer mortality in Japan: The JACC Study. Reviewed

    Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

    Int J Obes Relat Metab Disord   Vol. 28 ( 4 ) page: 551-8   2004

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  233. A prospective study on the possible association between having children and colon cancer risk: findings from the JACC Study. Reviewed

    Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

    Cancer Sci   Vol. 95 ( 3 ) page: 243-7   2004

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  234. A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: findings from the JACC study. Reviewed

    Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A; JACC Study Group.

    Cancer Sci   Vol. 95 ( 7 ) page: 602-7   2004

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  235. Association of white blood cell count and clustered components of metabolic syndrome in Japanese men. Reviewed

    Nagasawa N, Tamakoshi K, Yatsuya H, Hori Y, Ishikawa M, Murata C, Zhang H, Wada K, Otsuka R, Mabuchi T, Kondo T, Toyoshima H.

    Circ J   Vol. 68 ( 10 ) page: 892-7   2004

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  236. Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases. Reviewed

    Yatsuya H, Tamakoshi K, Hattori H, Otsuka R, Wada K, Zhang H, Mabuchi T, Ishikawa M, Murata C, Yoshida T, Kondo T, Toyoshima H.

    Circulation Journal   Vol. 68 ( 1 ) page: 11-16   2004

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    BACKGROUND: Phospholipid transfer protein (PLTP) can generate pre-beta high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease. METHODS AND RESULTS: Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized beta=0.395, -0.191, -0.064, and -0.064, respectively; R(2)=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95% confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke. CONCLUSIONS: The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.

  237. 人間ドックの有効性と限界 Invited

    玉腰浩司, 八谷寛, 豊嶋英明.

    総合臨床   Vol. 53   page: 2435-2438   2004

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  238. 玉腰浩司,八谷寛,豊嶋英明. Invited

      Vol. 208   page: 229-230   2004

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  239. 肥満を伴った高脂血症患者に対する運動療法の効果に関する研究 行動医学的アプローチを用いた運動習慣の定着による動脈硬化促進要因の改善に関する研究 Invited

    下光輝一, 井上茂, 小田切優子, 高波嘉一, 豊嶋英明, 八谷寛, 玉腰浩司, 近藤高明, 井口ちよ

    医科学応用研究財団研究報告   Vol. 21   page: 215-223   2004

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  240. 日本人男性における血清レプチン濃度と5年間追跡後の体重変化. Invited

    八谷寛, 玉腰浩司, 大塚礼, 間淵智子, 和田恵子, 張恵明, 村田千代栄, 石川美由紀, 近藤高明, 豊嶋英明.

    健康医科学研究助成論文集   Vol. 19   page: 110-117   2004

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  241. 肥満者における心血管疾患発症の過剰リスクを説明する新しい軸-血清レプチン値と白血球数の関連- Invited

    八谷寛, 淵智子, 大塚礼, 和田恵子, 長澤伸江, 張恵明, 村田千代栄, 石川美由紀, 堀容子, 近藤高明, 玉腰浩司, 豊嶋英明.

    健康管理事業団研究助成論文集   Vol. 10   page: 19-25   2004

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  242. Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study. Reviewed

    Yatsuya H, Toyoshima H, Tamakoshi A, Kikuchi S, Tamakoshi K, Kondo T, Mizoue T, Tokui N, Hoshiyama Y, Sakata K, Hayakawa N, Yoshimura T; Japan Collaborative Cohort Study Group.

    British Journal of Cancer   Vol. 91 ( 5 ) page: 929-934   2004

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    We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58-16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.

  243. Association of flatfoot with pain, fatigue and obesity in Japanese over sixties. Reviewed

    Otsuka R, Yatsuya H, Miura Y, Murata C, Tamakoshi K, Oshiro K, Nishio N, Ishikawa M, Zhang HM, Shiozawa M, Kobayashi A, Ito M, Hori Y, Kondo T, Toyoshima H.

    Nippon Koshu Eisei Zasshi   Vol. 50 ( 10 ) page: 988-98   2003.10

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  244. Effect of tactile interference stimulation of the ear in human primary somatosensory cortex: a magnetoencephalographic study. Reviewed

    Nihashi T, Kakigi R, Hoshiyama M, Miki K, Kajita Y, Yoshida J, Yatsuya H.

    Clin Neurophysiol   Vol. 114 ( 10 ) page: 1866-78   2003.10

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  245. Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Ishikawa M, Zhang H, Murata C, Otsuka R, Mabuchi T, Hori Y, Zhu S, Yoshida T, Toyoshima H.

    Int J Obes Relat Metab Disord   Vol. 27 ( 9 ) page: 1059-65   2003.9

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  246. Aggregation of stomach cancer history in parents and offspring in comparison with other sites. Reviewed

    Kondo T, Toyoshima H, Tsuzuki Y, Hori Y, Yatsuya H, Tamakoshi K, Tamakoshi A, Ohno Y, Kikuchi S, Sakata K, Hoshiyama Y, Hayakawa N, Tokui N, Mizoue T, Yoshimura T.

    Int J Epidemiol     page: 579-83   2003.8

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  247. Prospective study of screening for stomach cancer in Japan. Reviewed

    Mizoue T, Yoshimura T, Tokui N, Hoshiyama Y, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Fujino Y, Kaneko S; Japan Collaborative Cohort Study Group.

    Int J Cancer   Vol. 106 ( 1 ) page: 103-7   2003.8

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  248. The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Ishikawa M, Zhang H, Murata C, Otsuka R, Zhu S, Toyoshima H.

    Int J Obes Relat Metab Disord   Vol. 27 ( 4 ) page: 443-9   2003.4

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  249. U-shaped association between white blood cell count and fasting plasma glucose level. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Zhang H, Ishikawa M, Murata C, Otsuka R, Zhu S, Toyoshima H.

    Diabetes Care   Vol. 26 ( 3 ) page: 950   2003.3

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  250. The accuracy of long-term recall of past body weight in Japanese adult men. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Hirano T, Hori Y, Yoshida T, Toyoshima H.

    Int J Obes Relat Metab Disord   Vol. 27 ( 2 ) page: 247-52   2003.2

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  251. Gender and age differences in lifestyle factors related to hypertension in middle-aged civil service employees. Reviewed

    Hori Y, Toyoshima H, Kondo T, Tamakoshi K, Yatsuya H, Zhu S, Kawamura T, Toyama J, Okamoto N.

    J Epidemiol   Vol. 13 ( 1 ) page: 38-47   2003.1

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  252. Reproducibility and validity of a simple checklist-type questionnaire for food intake and dietary behavior. Reviewed

    Yatsuya H, Ohwaki A, Tamakoshi K, Wakai K, Koide K, Otsuka R, Mabuchi T, Murata C, Zhang H, Ishikawa M, Kondo T, Toyoshima H.

    Journal of Epidemiology   Vol. 13 ( 5 ) page: 235-245   2003

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    BACKGROUND: A simple, reliable, and valid food questionnaire is needed in clinical dietary assessments, community health education, and multi-purpose epidemiologic studies to obtain a crude measure of dietary intake. METHODS: To assess the validity and reproducibility of a simple 4-point scale food intake and behavior checklist, it was compared to two 3-day weighed dietary records. The FBC was administered to 47 students of a dietician course and their parents (n = 94) over a 9-month interval to assess the reproducibility. The mean intakes of selected food groups assessed by the two dietary records completed between food intake and behavior checklists were compared to the responses to the food intake and behavior checklist to assess its validity. RESULTS: The kappa statistics for reproducibility ranged from 0.25 for confectionaries to 0.63 for a preference for fatty foods (median, 0.39). There was a reasonable level of correlation between the dietary record and the food intake and behavior checklist in the intake of eggs, milk, and fruits (r = 0.53, 0.56, and 0.50, respectively). There was a weaker but still significant correlation in the intake of vegetables, and alcohol (r = 0.31 and 0.45, respectively). No significant correlation was observed in the intake of meat, fish, confectionaries, and soft drinks. However, those who reported consuming mainly fish rather than meat were found to eat significantly less meat and animal fat. Similarly, those who did not prefer fatty foods consumed significantly less meat, animal fat, and polyunsaturated fatty acids. CONCLUSIONS: This simple food checklist was useful in collecting data on egg, milk, and fruit consumption. Assessing intake frequency of vegetables, meat or fish with the FBC may be useful in screening high- or low-intake individuals.

  253. クリティカルパスの実際: 高血圧クリティカルパス Invited

    堀容子, 齊藤郁夫, 鈴木一夫, 長谷川敏彦, 星野純子, 八谷寛, 玉腰浩司, 近藤高明, 豊嶋英明, 村地俊二.

    成人病と生活習慣病   Vol. 33   page: 687-692   2003

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  254. わが国における心筋梗塞と脳卒中 疫学的検討:高脂血症の疫学と心筋梗塞,脳卒中 Invited

    玉腰浩司, 八谷寛, 近藤高明, 豊嶋英明.

    循環器科   Vol. 54   page: 372-379   2003

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  255. 肥満と動脈硬化:肥満度の指標" Invited

    八谷寛, 玉腰浩司, 近藤高明, 豊嶋英明.

    動脈硬化予防   Vol. 2   page: 17-23   2003

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  256. 後期高齢者における転倒関連要因についての検討 サテライト型デイサービス利用者を対象として Reviewed

    堀容子, 近藤高明, 玉腰浩司, 八谷寛, 滝益栄, 小林督子, 北澤百合子, 代田妙子, 豊嶋英明.

    日本赤十字愛知短期大学紀要   Vol. 14   page: 139-146   2003

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  257. 地域在住高齢者における扁平足と足の自覚症状,及び肥満との関連 Reviewed

    大塚礼, 八谷寛, 三浦弥生, 村田千代栄, 玉腰浩司, 大城宏治, 西尾直樹, 石川美由紀, 張恵明, 塩澤まゆみ, 小林あゆみ, 伊藤美果, 堀容子, 近藤高明, 豊嶋英明.

    日本公衆衛生雑誌   Vol. 50   page: 988-998   2003

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  258. Association between weight fluctuation and fasting insulin concentration in Japanese men. Reviewed

    Yatsuya H, Tamakoshi K, Yoshida T, Hori Y, Zhang H, Ishikawa M, Zhu S, Kondo T, Toyoshima H.

    International Journal of Obesity and Related Metabolic Disorders   Vol. 27 ( 4 ) page: 478-483   2003

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    OBJECTIVE: To investigate whether long-term weight fluctuation is associated with the fasting serum insulin concentration. DESIGN AND SUBJECTS: Weight histories of 1932 male Japanese workers aged 40-59 y were analyzed in relation to their current fasting serum insulin concentration. MEASUREMENTS: Individual weight fluctuation was calculated by root mean square error (RMSE) along the linear regression line of weight measured at five to six different ages. RESULTS: The mean RMSE and fasting insulin concentration were 1.22 kg and 4.5 microU/ml, respectively. The multivariate adjusted insulin level became higher with the increase in weight fluctuation. Subanalysis stratified by current body mass index (BMI) showed that the multivariate adjusted insulin level in individuals in the top quartile of fluctuation was 4.3 microU/ml, against 3.9 microU/ml in those in the bottom quartile (P=0.018, analysis of covariance (ANCOVA)) in the normal weight subgroup with current BMI below 25 kg/m(2). In the overweight subgroup with BMI 25 kg/m(2) or above, the level was 6.9 microU/ml in individuals in the top quartile and 6.2 microU/ml in those in the bottom quartile (P=0.054, ANCOVA). CONCLUSION: The results suggest that weight fluctuation increases the risk of developing hyperinsulinemia. Prospective observations together with measurement of changes in adiposity are needed for confirmation.

  259. A prospective study of stomach cancer death in relation to green tea consumption in Japan. Reviewed

    Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T; Japan Collaborative Cohort Study Group.

    Br J Cancer   Vol. 87 ( 3 ) page: 309-13   2002.7

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  260. Role of the anterolateral thigh flap in head and neck reconstruction: advantages of moderate skin and subcutaneous thickness. Reviewed

    Nakayama B, Hyodo I, Hasegawa Y, Fujimoto Y, Matsuura H, Yatsuya H, Torii S.

    J Reconstr Microsurg   Vol. 18 ( 3 ) page: 141-6   2002.4

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  261. Short- and long-term reliability of information on previous illness and family history as compared with that on smoking and drinking habits in questionnaire surveys. Reviewed

    Zhu S, Toyoshima H, Kondo T, Tamakoshi K, Yatsuya H, Hori Y, Tsubono Y, Nishino Y, Tsuji I, Hisamichi S.

    J Epidemiol   Vol. 12 ( 2 ) page: 120-5   2002.3

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  262. Family history and the risk of stomach cancer death in Japan: differences by age and gender. Reviewed

    Yatsuya H, Toyoshima H, Mizoue T, Kondo T, Tamakoshi K, Hori Y, Tokui N, Hoshiyama Y, Kikuchi S, Sakata K, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T.

    International Journal of Cancer   Vol. 97 ( 5 ) page: 688-694   2002

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    Familial aggregation of stomach cancer has long been observed. The effect on disease risk of family history and its magnitude according to the type of affected relatives, however, is not well known. We conducted a prospective analysis using the JACC study (Japan Collaborative Cohort Study For Evaluation of Cancer Risk, sponsored by Monbusho) data. During the follow-up period, 662 stomach cancer deaths were documented. A positive history of stomach cancer in one or more first-degree relatives was associated with a significantly increased risk of death from the disease in both men (RR 1.60; 95% CI 1.11-2.31) and women (RR 2.47; 95% CI 1.50-4.06). In the subanalysis stratified by age, the association between positive family history and stomach cancer was stronger in the age group from 40-59 (RR 2.62; 95% CI 1.34-5.11 for men and RR 5.88; 95% CI 2.70-12.82 for women) than in the age group from 60-79 (RR 1.31; 95% CI 0.84-2.05 for men and RR 1.44; 95% CI 0.72-2.88 for women). In the age group from 40-59, men with father's history and women with mother's and sister's history of the disease had a significantly increased risk (RR 3.14; 95% CI 1.51-6.55, RR 10.46; 95% CI 4.54-24.12, RR 13.39; 95% CI 3.89-46.12, respectively). When 2 or more family members were affected, the increment in the risk was prominent especially in women (RR 9.45; 95% CI 4.46-20.05). These results suggest the existence of a certain subtype of stomach cancer that is inherited more often by women from one generation to the next in gender-influenced fashion. Any preventive strategy should take into account the degree of individual susceptibility.

  263. Trends in the mortality (1950-1997) and incidence (1975-1993) of malignant ovarian neoplasm among Japanese women: analyses by age, time, and birth cohort. Reviewed

    Tamakoshi K, Kondo T, Yatsuya H, Hori Y, Kikkawa F, Toyoshima H.

    Gynecol Oncol   Vol. 83 ( 1 ) page: 64-71   2001.10

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  264. 若年者の死亡について Invited

    玉腰浩司、八谷寛、堀容子、近藤高明、豊嶋英明.

    現代医学   Vol. 49   page: 169-173   2001

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  265. 産業保健における循環器疾患の一次予防対策 Invited

    豊嶋英明、八谷寛、近藤高明、玉腰浩司.

    産業医学レビュー   Vol. 13   page: 155-182   2001

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  266. A case of eosinophilic peritonitis in which ascites interleukin 5 presented at a high level.Hepatogastroenterology. Reviewed

    Yoshikane H, Yatsuya H, Sakakibara A, Hidano H, Arisawa T, Goto H.

    Hepatogastroenterology   Vol. 47 ( 36 ) page: 1588-9   2000

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  267. 成人における循環器疾患:進展とその予防. その1: 心疾患 Invited

    豊嶋英明、八谷寛.

    循環器専門医   Vol. 8   page: 55-62   2000

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  268. 職域大規模集団における健診成績のデータベース化とバイオマテリアル長期保存における生活習慣病の予防対策 高脂血症者における食習慣の変容に関する横断的解析結果 Invited

    八谷寛, 近藤高明, 堀容子, 玉腰浩司, 朱善寛, 川村孝, 吉田勉, 外山淳治, 岡本登, 島正吾, 豊嶋英明.

    協栄生命健康事業団研究助成論文集   Vol. 15   page: 65-73   1999

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  269. 発展途上国における下痢症の現状とその対策についての考察" Reviewed

    八谷寛, 豊嶋英明, 宮尾克, 肥田野等.

    社会医学研究   Vol. 17   page: 47-51   1999

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  270. 日本の疾病負担と障害調整生存年(DALY) Reviewed

    福田吉治, 長谷川敏彦, 八谷寛, 田端航也.

    厚生の指標   Vol. 46   page: 28-33   1999

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▼display all

Books 10

  1. Obesity Epidemiology

    ( Role: Joint author)

    2010.10 

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  2. アディポネクチンとその受容体-抗生活習慣病ホルモンの全貌-門脇孝編(心肥大とアディポネクチン)

    三橋弘嗣、八谷寛、室原豊明、豊嶋英明、玉腰浩司( Role: Joint author)

    フジメディカル出版  2008.5 

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  3. 動脈硬化・老年病予防健診マニュアル(胸部X線(心胸郭比))

    八谷寛、豊嶋英明. 小澤秀樹編( Role: Joint author)

    メジカルビュー社  2001 

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  4. 循環器病予防ハンドブック(胸写・心電図)

    豊嶋英明、八谷寛、堀容子. 日本循環器管理研究協議会編.( Role: Joint author)

    保健同人社  2003 

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  5. 循環器疾患の予防・管理・治療マニュアル(胸写・心電図)

    豊嶋英明、八谷寛、堀容子.日本循環器管理研究協議会編.( Role: Joint author)

    保健同人社  2003 

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  6. がん予防の最前線(胃がん)

    八谷寛, 星山佳治, 菊地正悟, 藤野善久, 吉村健清. 田島和雄監修( Role: Joint author)

    昭和堂  2005 

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  7. JACC Study −これまでの成果とあゆみ− Reviewed

    松永眞章、王超辰、八谷寛( Role: Joint author ,  脳血管疾患)

    予防医学広報事業団(⻘⽊平⼋郎・國雄記念)  2021.3  ( ISBN:978-4-9911825-0-1

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  8. テキスト健康科学

    八谷寛, 太田充彦(担当:分担執筆, 範囲:第4章 社会と健康)( Role: Joint author)

    南江堂  2017.2 

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  9. Textbook of Health Science

    Hiroshi Yatsuya, Atsuhiko Ota( Role: Contributor)

    2017.2 

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  10. 循環器病健康診査の手技と判定基準:肥満(循環器病予防ハンドブック 第7版)

    八谷寛、藤吉朗( Role: Joint author)

    保健同人社  2014.7 

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MISC 46

  1. 安全衛生担当労働者における加熱式タバコの利用状況

    加藤 善士, 太田 充彦, 八谷 寛

    厚生の指標   Vol. 67 ( 6 ) page: 23 - 28   2020.6

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    目的 職域では受動喫煙対策とともに喫煙労働者への禁煙指導が課題となっている。日本の職域における加熱式タバコの使用実態を報告した論文は少ない。本研究の目的は,職域における加熱式タバコの使用実態を把握し,喫煙対策の実施につながる知見を得ることである。方法 某労働災害防止団体の地方センターにおいて2019年4月〜6月末の3ヵ月間に開催した安全衛生教育受講者(819人)を対象にした自記式質問紙調査を実施した。喫煙率,加熱式タバコ利用状況,年齢,性別,役職,企業規模,喫煙習慣との関連を調べた。回答者741人のうち,男性回答者で分析に必要な項目に欠損がなかった653人を解析した。結果 喫煙率は37.8%(247人)であった。現喫煙者割合は40〜49歳で高く(40.1%),過去喫煙者割合は50歳以上で高く(37.8%),非喫煙者割合は40歳未満で高かった(49.1%)(p<0.001)。役職,企業規模と現喫煙,過去喫煙,非喫煙の割合に有意な関連は認めなかった。現喫煙者247人の内,加熱式タバコのみを利用する者が67人(現喫煙者の27.1%),加熱式タバコと通常のタバコとの併用者が55人(現喫煙者の22.3%)であった。加熱式タバコの利用状況(加熱式のみ,併用,通常のタバコのみ)と年齢,役職,企業規模との間に統計学的に有意な関連は認めなかった。加熱式タバコの利用理由は「においが少ない」(67.2%),「煙が少ない」(47.5%),「火の心配が少ない」(43.4%),「自分の健康被害が少ないと思う」(35.2%),「周囲の健康被害が少ないと思う」(34.4%)であった。結論 男性労働者の喫煙率には年齢による差はあったが,企業規模や役職による差はなかった。男性労働者の加熱式タバコの利用は20%程度で,全喫煙者の約半分であった。本研究では,健康被害よりもにおいや火に関連した危険を理由として加熱式タバコを利用する者が多かった。事業場においては,通常のタバコへの喫煙対策と併せて加熱式タバコへの対策も行うことが望まれる。(著者抄録)

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  2. 中年期の空腹時血糖と高齢期の認知機能との関連:愛知職域コホート研究

    霜田真子, 八谷寛, 加藤綾子, 金子佳世, 中川威, 河野直子, 大塚礼, 太田充彦, 内藤久雄, 李媛英, 市野直浩, 山田宏哉, 江啓発, 平川仁尚, 玉腰浩司, 青山温子, 青山温子

    日本疫学会学術総会講演集(Web)   Vol. 30th   2020

  3. 肥満に関連する疾病の増加と対策

    八谷 寛

    日本医史学雑誌   Vol. 65 ( 2 ) page: 172 - 172   2019.6

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  4. 日常的なライフスタイルを如何に論文化するか? 複合的な健康習慣の指標と循環器病予防

    八谷 寛, 玉腰 浩司

    日本循環器病予防学会誌   Vol. 54 ( 2 ) page: 106 - 106   2019.4

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  5. 日本のがん患者の復職率 システマティックレビュー

    太田 充彦, 藤澤 明子, 河田 健司, 八谷 寛

    日本衛生学雑誌   Vol. 74 ( Suppl. ) page: S128 - S128   2019.2

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  6. 高血圧ラットは肝臓Cyp7a1 promoterメチル化頻度が高く、降圧剤投与で一部低下する

    内藤 久雄, 三宅 邦夫, 橋本 沙幸, 浅野 友美, 北森 一哉, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 74 ( Suppl. ) page: S177 - S177   2019.2

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  7. 高血圧ラットは肝臓Cyp7a1 promoterメチル化頻度が高く、降圧剤投与で一部低下する

    内藤 久雄, 三宅 邦夫, 橋本 沙幸, 浅野 友美, 北森 一哉, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 74 ( Suppl. ) page: S177 - S177   2019.2

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  8. γGTPとALT追加による10年間の2型糖尿病発症リスク予測能の改善 愛知職域コホート International journal

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 豊嶋 英明, 青山 温子

    日本公衆衛生学会総会抄録集   Vol. 77回   page: 204 - 204   2018.10

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  9. 食品摂取の多様性と尿中Na,K排泄量、血圧との関連 NIPPON DATA2010

    大塚 礼, 八谷 寛, 西 信雄, 奥田 奈賀子, 門田 文, 由田 克士, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之

    日本公衆衛生学会総会抄録集   Vol. 77回   page: 322 - 322   2018.10

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  10. 健診と健康(地域健診、特定健診、職場健診は日本人の健康に寄与しているか?) 職域における若年期からの肥満対策と循環器病予防

    八谷 寛, 李 媛英, 平川 仁尚, 太田 充彦, 上村 真由, 江 啓発, 金子 佳世, 豊嶋 英明, 玉腰 浩司, 青山 温子

    日本循環器病予防学会誌   Vol. 53 ( 2 ) page: 166 - 166   2018.5

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  11. 成人男性におけるGGTとALTの組み合わせと2型糖尿病発症の関連 愛知職域コホート研究

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 青山 温子

    日本循環器病予防学会誌   Vol. 53 ( 2 ) page: 182 - 182   2018.5

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  12. 健診と健康(地域健診、特定健診、職場健診は日本人の健康に寄与しているか?) 職域における若年期からの肥満対策と循環器病予防

    八谷 寛, 李 媛英, 平川 仁尚, 太田 充彦, 上村 真由, 江 啓発, 金子 佳世, 豊嶋 英明, 玉腰 浩司, 青山 温子

    日本循環器病予防学会誌   Vol. 53 ( 2 ) page: 166 - 166   2018.5

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  13. 成人男性におけるGGTとALTの組み合わせと2型糖尿病発症の関連 愛知職域コホート研究

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 青山 温子

    日本循環器病予防学会誌   Vol. 53 ( 2 ) page: 182 - 182   2018.5

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  14. IoT(Internet of Things)システムの糖尿病療養指導への応用

    小林 朋子, 後藤 資実, 尾上 剛史, 村本 あき子, 加藤 綾子, 栄口 由香里, 野村 恵里, 武藤 繁貴, 八谷 寛, 津下 一代, 有馬 寛

    糖尿病   Vol. 61 ( Suppl.1 ) page: S - 440   2018.4

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  15. DPCデータを用いた脳卒中・急性心筋梗塞発症把握の可能性の検討

    柿崎 真沙子, 澤田 典絵, 山岸 良匡, 八谷 寛, 斉藤 功, 小久保 喜弘, 磯 博康, 津金 昌一郎, 康永 秀生

    日本公衆衛生雑誌   Vol. 65 ( 4 ) page: 179 - 186   2018.4

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    目的 DPCデータを大規模なコホート研究の発症登録に利用することが可能であるかを検討するため、独自に収集した脳卒中および急性心筋梗塞発症登録数と、DPCデータを活用して得られた疾病登録数との比較を行い、脳卒中と急性心筋梗塞の各診断名において実施された治療・処置や検査から、標的疾患罹患の把握に有用な項目があるか検討した。方法 研究対象病院のDPCデータから、4種類(主傷病名、入院の契機となった病名、医療資源を最も投入した病名、医療資源を二番目に投入した病名)のいずれかに、急性心筋梗塞、脳内出血、脳梗塞が含まれる症例を抽出し、疾患ごとに実施された検査や治療の情報を抽出・集計し当該研究対象病院にてJPHC研究の一部として独自に収集した発症登録により得られた登録数を比較した。結果 DPLデータで抽出された症例数は独自に実施した発症登録数より多かったが、その差はとくに脳梗塞において顕著であった。JPHC登録数/DPC症例数の比は心筋梗塞1.13、脳内出血0.88、脳梗塞0.67であった。結論 急性心筋梗塞および脳内出血の疾病登録にはDPCデータを利用して、対象者数を概ね把握できる可能性が示された。脳梗塞についてはDPC登録病名とDPC治療・検査・診断項目を補助的に活用することで、疾病登録対象者数の同定精度を高め得る可能性がある。しかしながら、DPCデータを大規模なコホート研究の発症登録に利用するためには、地域全体での発症数がDPC導入病院の発症数でカバーできるのか、さらなる検討が必要である。(著者抄録)

    DOI: 10.11236/jph.65.4_179

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J01074&link_issn=&doc_id=20180511440004&doc_link_id=130006731380&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130006731380&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

  16. トリクロロエチレンによる過敏症症候群における曝露濃度と感受性因子の交互作用 International coauthorship

    那須 民江, 王 海蘭, 伊藤 由起, 内藤 久雄, 柳場 由絵, 八谷 寛, 上島 通浩

    日本衛生学雑誌   Vol. 73 ( Suppl. ) page: S276 - S276   2018.3

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  17. 某労働基準監督署管内2事業場(製造業)における「治療と職業生活の両立支援のためのガイドライン」の周知状況について

    加藤 善士, 太田 充彦, 八谷 寛

    産業衛生学雑誌   Vol. 60 ( 2 ) page: 55 - 55   2018.3

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  18. 高血圧及び高脂肪食摂取はラット肝臓Cyp7a1プロモーターのメチル化頻度を増加させる

    内藤 久雄, 三宅 邦夫, 袁 媛, 橋本 沙幸, 北森 一哉, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 73 ( Suppl. ) page: S230 - S230   2018.3

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  19. 警察官採用に関わる色彩識別能力評価基準について

    高柳 泰世, 八谷 寛, 宮尾 克, 太田 充彦

    産業衛生学雑誌   Vol. 60 ( 2 ) page: 55 - 55   2018.3

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  20. 警察官採用に関わる色彩識別能力評価基準について

    高柳 泰世, 八谷 寛, 宮尾 克, 太田 充彦

    産業衛生学雑誌   Vol. 60 ( 2 ) page: 55 - 55   2018.3

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  21. 某労働基準監督署管内2事業場(製造業)における「治療と職業生活の両立支援のためのガイドライン」の周知状況について

    加藤 善士, 太田 充彦, 八谷 寛

    産業衛生学雑誌   Vol. 60 ( 2 ) page: 55 - 55   2018.3

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  22. トリクロロエチレンによる過敏症症候群における曝露濃度と感受性因子の交互作用

    那須 民江, 王 海蘭, 伊藤 由起, 内藤 久雄, 柳場 由絵, 八谷 寛, 上島 通浩

    日本衛生学雑誌   Vol. 73 ( Suppl. ) page: S276 - S276   2018.3

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  23. 高血圧及び高脂肪食摂取はラット肝臓Cyp7a1プロモーターのメチル化頻度を増加させる

    内藤 久雄, 三宅 邦夫, 袁 媛, 橋本 沙幸, 北森 一哉, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 73 ( Suppl. ) page: S230 - S230   2018.3

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  24. 自宅から鉄道駅,バス停,職場までの距離と歩行時間との関連―愛知職域コホート

    八谷寛, 八谷寛, 李媛英, 埴淵知哉, 平川仁尚, 太田充彦, 加藤善士, 藤澤明子, 松永眞章, 大塚礼, 村田千代栄, 江啓発, 玉腰浩司, 豊嶋英明, 青山温子

    日本疫学会学術総会講演集(Web)   Vol. 28th   page: 129 (WEB ONLY)   2018.2

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  25. 日本人一般住民における教育歴・経済状態と炎症マーカーの関連:NIPPON DATA2010

    村上慶子, 大久保孝義, 渡邉至, 二宮利治, 大西浩文, 八谷寛, 高嶋直敬, 宮川尚子, 門田文, 奥田奈賀子, 西信雄, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    日本疫学会学術総会講演集(Web)   Vol. 28th   page: 114 (WEB ONLY)   2018.2

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  26. 料理ベース食事調査Webシステムのコホートでの活用に関するパイロット研究~第1報 実施方法と回答状況~

    藤田みほ, 石原淳子, 八谷寛, 八谷寛, 田中純太, 西本侑加, 丸谷幸子, 平川仁尚, 江啓発, 加藤祐子, 澤田典絵, 井上真奈美, 青山温子, 高地リベカ

    日本疫学会学術総会講演集(Web)   Vol. 28th   page: 103 (WEB ONLY)   2018.2

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  27. 料理データベース食事調査Webシステムのコホートでの活用に関するパイロット研究~第2報 摂取量の推定結果~

    加藤祐子, 石原淳子, 八谷寛, 八谷寛, 田中純太, 藤田みほ, 西本侑加, 丸谷幸子, 青山温子, 平川仁尚, 江啓発, 澤田典絵, 井上真奈美, 高地リベカ

    日本疫学会学術総会講演集(Web)   Vol. 28th   page: 104 (WEB ONLY)   2018.2

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  28. 食品摂取の多様性と心血管危険因子に関する検討:NIPPON DATA2010

    大塚礼, 大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 門田文, 由田克士, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    日本疫学会学術総会講演集(Web)   Vol. 28th   page: 116 (WEB ONLY)   2018.2

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  29. Pilot peer health education for noncommunicable disease prevention in Bangladesh, Ethiopia, and Palau

    Lemlem W Gebremariam, Yoshihisa Hirakawa, Shahrin E Rayna, Fahmida A Khan, Chifa Chiang, Yupeng He, Everlynn J Temengil, Sherilynn Madraisau, Md Khalequzzaman, Sohel R Choudhury, Hiroshi Yatsuya, Atsuko Aoyama

    Journal of global health report   Vol. 2   page: e2018039   2018

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  30. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 食品摂取の多様性と心血管危険因子に関する検討:NIPPON DATA2010

    大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 門田文, 由田克士, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成29年度 総括・分担研究報告書(Web)     page: 91‐94 (WEB ONLY)   2018

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  31. わが国の循環器疾患の危険因子「冠動脈疾患」

    松永 眞章, 八谷 寛

    日本循環器病予防学会誌   Vol. 52 ( 3 ) page: 244 - 254   2017.12

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    国際的には低い冠動脈疾患発症率を誇るわが国ではあるが、肥満や不活発な生活習慣の蔓延による耐機能異常、脂質異常の割合の増加により、男性、特に都市部男性における発症率の増加が示唆されている。わが国における冠動脈疾患の危険因子(高血圧、脂質異常症、糖尿病、喫煙、肥満、メタボリックシンドローム、慢性腎臓病、飲酒)について、定義、冠動脈疾患発症、死亡との関連の特徴などについて個々に概説した。

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  32. 家庭での受動喫煙とその後のCOPDによる死亡との関連 JACC Study

    鵜川 重和, 玉腰 暁子, 八谷 寛, 山岸 良匡, 安藤 昌彦, 磯 博康

    北海道公衆衛生学雑誌   Vol. 31 ( 1特別付録 ) page: 90 - 90   2017.11

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  33. 家庭での受動喫煙とその後のCOPDによる死亡との関連 JACC Study

    鵜川 重和, 玉腰 暁子, 八谷 寛, 山岸 良匡, 安藤 昌彦, 磯 博康

    北海道公衆衛生学雑誌   Vol. 31 ( 1特別付録 ) page: 90 - 90   2017.11

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  34. Internet of Things(IoT)を活用した生活習慣改善支援の取り組み

    野村 恵里, 栄口 由香里, 加藤 綾子, 村本 あき子, 武藤 繁貴, 八谷 寛, 津下 一代

    日本公衆衛生学会総会抄録集   Vol. 76回   page: 454 - 454   2017.10

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  35. パラオにおける食行動(果物・野菜摂取及び外食の頻度)と肥満との関連

    大内 詩野, 崔 仁哲, 本庄 かおり, 江 啓発, 八谷 寛, 青山 温子, 磯 博康

    日本公衆衛生学会総会抄録集   Vol. 76回   page: 411 - 411   2017.10

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  36. パラオ共和国の若年者における飲酒と薬物使用の現状

    佐田 みずき, 崔 仁哲, 江 啓発, 八谷 寛, 本庄 かおり, 三田 貴, 磯 博康, 青山 温子

    日本アルコール・薬物医学会雑誌   Vol. 52 ( 4 ) page: 211 - 211   2017.8

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  37. 某労働基準監督署管内事業場における治療と職業生活の両立支援のための職場環境・労務管理制度

    加藤 善士, 太田 充彦, 八谷 寛

    東海公衆衛生雑誌   Vol. 5 ( 1 ) page: 102 - 110   2017.7

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    目的 「事業場における治療と職業生活の両立支援のためのガイドライン(両立支援ガイドライン)」の認知、両立支援のための職場環境・労務管理体制の整備の実態、それらと事業場規模、事業場内産業保健スタッフ、過去の私傷病退職者・がん罹患者の有無との関連の探索。方法 某労働基準監督署管内の1,002事業場を対象に自記式質問紙調査を実施した。両立支援ガイドラインの認知割合、両立支援のための職場環境として啓発研修、相談・申出窓口、事業場内外の関係者間の情報交換の枠組みの有無、および、私傷病時に利用可能な労務管理制度として時差出勤、所定労働時間の短縮、時間単位の休暇、試し出勤、傷病・病気休暇の有無を調べ、事業場の規模による違いをコクラン・アーミテージ検定にて検定した。それらと事業場内産業保健スタッフ、および過去3年間に私傷病で退職した従業員・がんに罹患した従業員の有無との関連を調べ、Fisher正確確率検定で検定した。結果 266事業場から回答があり、回答率は27%であった。両立支援ガイドライン認知の割合は19%で、その割合は事業場規模が大きいほど高かった。啓発研修は7%、相談・申出窓口は38%、情報交換の枠組みは33%の事業場で行われており、事業場規模が大きいほどこの割合が高かった。従業員数50人未満の小規模事業場においては、事業場内産業保健スタッフのいる事業場で啓発研修(20%)、相談・申出窓口(52%)、情報交換の枠組み(48%)の実施割合が産業保健スタッフのいない事業場よりも高かった。両立支援のための各種労務管理制度の導入割合は1〜3割で、時間単位の休暇および傷病休暇・病気休暇は、事業場規模が大きいほど導入割合が高かった。過去3年間に私傷病で退職した従業員・がんに罹患した従業員の有無と両立支援のための職場環境・労務管理制度の有意な関連はなかった。ガイドラインを認知していた事業場では、従業員数50〜299人の中規模事業場では所定労働時間の短縮がより多く実施されていた。結論 両立支援ガイドライン認知の割合は低く、さらなる周知が望ましい。両立支援のための職場環境・労務管理制度の導入割合は一部先行研究よりも高く、事業場規模、産業保健スタッフの有無による違いを認めた。(著者抄録)

    DOI: 10.24802/tpha.5.1_102

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J06245&link_issn=&doc_id=20170711480055&doc_link_id=%2Ffe4tokai%2F2017%2Fs00501%2F007%2F0102-0110%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffe4tokai%2F2017%2Fs00501%2F007%2F0102-0110%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  38. IoT(Internet of Things)システムを用いた療養指導強化による糖代謝改善についての検討 教育入院患者を対象とした前向き研究

    小林 朋子, 後藤 資実, 尾上 剛史, 村本 あき子, 加藤 綾子, 栄口 由香里, 野村 恵里, 武藤 繁貴, 八谷 寛, 津下 一代, 有馬 寛

    糖尿病   Vol. 60 ( Suppl.1 ) page: S - 376   2017.4

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  39. 宿泊型新保健指導プログラム(第2報) 1年後の効果検証

    松下 まどか, 矢部 大介, 小熊 祐子, 佐野 喜子, 樺山 舞, 八谷 寛, 荒川 雅志, 村本 あき子, 津下 一代

    糖尿病   Vol. 60 ( Suppl.1 ) page: S - 245   2017.4

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  40. 【産業ストレスのバイオロジー:生物学的指標の現在と展望】 職業性心理社会的要因と視床下部-下垂体-副腎皮質系ホルモンの関連

    太田 充彦, 八谷 寛

    産業ストレス研究   Vol. 24 ( 2 ) page: 205 - 211   2017.4

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  41. 解毒酵素の発現抑制が食餌性由来肝線維化進展に重要である

    内藤 久雄, 賈 小芳, 北森 一哉, 袁 媛, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 72 ( Suppl. ) page: S218 - S218   2017.3

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  42. A Point-based Prediction Model for Predicting 10-year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study

    Yuanying Li, Hiroshi Yatsuya, Yoshihisa Hirakawa, Atsuhiko Ota, Masaaki Matsunaga, Hilawe Esayas Haregot, Chifa Chiang, Yan Zhang, Koji Tamakoshi, Hideaki Toyoshima, Atsuko Aoyama

    CIRCULATION   Vol. 135   2017.3

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  43. 社会的要因と食品摂取の多様性に関する検討:NIPPON DATA2010

    大塚礼, 大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 尾島俊之, 中村美詠子, 由田克士, 藤吉朗, 門田文, 大久保孝義, 近藤慶子, 宮川尚子, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    日本疫学会学術総会講演集(Web)   Vol. 27th   page: 141 (WEB ONLY)   2017.1

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  44. 地理的剥奪・ソーシャルキャピタルと主観的健康感の関連―愛知職域コホート

    村田千代栄, 八谷寛, 八谷寛, 埴淵知哉, 李媛英, 大塚礼, 豊嶋英明, 平川仁尚, 太田充彦, 加藤善士, 藤澤明子, 松永眞章, 江啓発, 玉腰浩司, 青山温子

    日本疫学会学術総会講演集(Web)   Vol. 27th   page: 116 (WEB ONLY)   2017.1

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  45. GISにより評価した自宅近隣のwalkabilityと散歩・早歩き習慣との関連―愛知職域コホート

    李媛英, 八谷寛, 八谷寛, 埴淵知哉, 平川仁尚, 太田充彦, 加藤善士, 藤澤明子, 松永眞章, 大塚礼, 村田千代栄, 江啓発, 玉腰浩司, 豊嶋英明, 青山温子

    日本疫学会学術総会講演集(Web)   Vol. 27th   page: 109 (WEB ONLY)   2017.1

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  46. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 社会的要因と食品摂取の多様性に関する検討:NIPPON DATA2010

    大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 尾島俊之, 中村美詠子, 由田克士, 藤吉朗, 門田文, 大久保孝義, 近藤慶子, 宮川尚子, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)     page: 80‐84 (WEB ONLY)   2017

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Presentations 92

  1. 第一次緊急事態宣言下における大学生の日常行動とメンタルヘルスとの関係

    橋本幸之助、江啓発、八谷寛、HE Yupeng、平野有希子、平川仁尚、太田充彦、若泉謙太、島津明人、田淵貴大

    第39回日本国際保健医療学会西日本地方会  2021.3.6 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Poster presentation  

  2. 職域における糖尿病の病態:発症予防・治療管理・予後 Invited

    八谷寛

    第55回糖尿病学の進歩  2021.3.5  日本糖尿病学会

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:札幌  

  3. Automated Web-based Assessment system using Recipe-Data for Japanese (AWARDJP) – a pilot study for the middle and old age population-base cohort studies in Japan International conference

    Ribeka Takachi, Junko Ishihara, Sachiko Maruya, Junta Tanaka, Hiroshi Yatsuya, Atsuko Aoyama, Yoshihisa Hirakawa, Chifa Chiang, Tsuneo Konta, Takamasa Kayama, Manami Inoue, Norie Sawada, Shoichiro Tsugane

    eICDAM (International Conference on Diet and Activity Methods) 2021  2021.2.8 

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    Event date: 2021.2

    Language:English   Presentation type:Poster presentation  

    Venue:Ede   Country:Netherlands  

  4. Comparison of artificial neural network and logistic regression for predicting common metabolic outcomes

    Yupeng HE, Chifa CHIANG, Yoshihisa HIRAKAWA, Hiroshi YATSUYA

    第31回日本疫学会学術総会  2021.1.27 

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    Event date: 2021.1

    Language:English   Presentation type:Oral presentation (general)  

  5. 職域男性就労者における現喫煙者の禁煙指導・意識と過去喫煙者の禁煙理由について(職域におけるアンケート調査から)

    加藤善士、太田充彦、八谷寛

    第66回東海公衆衛生学会  2020.7.11 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  6. 肥満度と心筋梗塞、脳卒中発症の関連---JALS研究シンポジウム 日本の心臓血管疾患の疫学研究:大規模コホート統合研究(JALS)

    八谷 寛

    第58回日本心臓病学会学術集会 

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    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  7. Conventional Risk Factors for Heart Failure Mortality: The JACC Study International conference

    50th Cardiovascular Disease Epidemiology and Prevention Annual Conference (American Heart Association) 

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    Event date: 2010.3

    Language:English   Presentation type:Poster presentation  

  8. Race and Sex-Specific Associations of Obesity Measures with Ischemic Stroke Incidencein the ARIC Study International conference

    50th Cardiovascular Disease Epidemiology and Prevention Annual Conference (American Heart Association) 

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    Event date: 2010.3

    Language:English   Presentation type:Poster presentation  

  9. Independent association of serum adiponectin and alanine amino transferase with the incidence of diabetes mellitus in middle-aged Japanese men: 5-year follow-up International conference

    Li Y, Yatsuya H, Toyoshima H, Iso H, Tamakoshi K.

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    Event date: 2010.1

    Language:English  

    Country:Japan  

  10. 職域集団から学ぶ肥満の成因と健康影響 産業保健課題としての肥満の成因・病態と予防

    豊嶋英明、八谷 寛、近藤良伸、玉腰浩司

    平成21年度日本産業衛生学会東海地方会学会シンポジウム 

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    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  11. Body mass index and mortality among Japanese older adults: Findings from the JACC Study International conference

    Obesity 2009―27th Annual Scientific Meeting of the Obesity Society 

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    Event date: 2009.10

    Language:English   Presentation type:Oral presentation (general)  

  12. 生活習慣とメタボリックシンドローム発症リスクに関する追跡研究

    李媛英、八谷寛、豊嶋英明、玉腰浩司

    第68回日本公衆衛生学会総会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  13. 勤労男性における「食事バランスガイド」を参考にした食生活の実現可能性と課題

    嶋田雅子、武見ゆかり、大久保公美、村上健太郎、大塚礼、八谷寛、佐々木敏

    第56回日本栄養改善学会学術総会 

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    Event date: 2009.9

    Language:Japanese  

    Country:Japan  

  14. 体格と身体活動の乳がんに対するリスク-JACC Studyの知見より.

    鈴木貞夫,小嶋雅代,徳留信寛,森満,坂内文男,藤野善久,若井建志,玉腰浩司,八谷寛,林櫻松,菊地正悟,玉腰暁子.

    第10回日本がん分子疫学研究会 第16回日本がん予防学会 第32回日本がん疫学研究会 

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    Event date: 2009.6

    Language:Japanese  

    Country:Japan  

  15. Body Mass Index and Risk of Stroke in Japanese Men and Women: A Meta-analysis of 16 Cohorts in Japan International conference

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    Event date: 2009.3

    Language:English   Presentation type:Poster presentation  

  16. 高齢者のBMIと総死亡リスク:JACCStudyから

    玉腰暁子, 林櫻松, 柳生聖子, 菊地正悟, 鈴木貞夫, 玉腰浩司, 近藤高明, 八谷寛

    第19回日本疫学会学術総会. 

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    Event date: 2009.1

    Language:Japanese  

    Country:Japan  

  17. Lifestyle and incidence of metabolic syndrome: a follow-up study International conference

    The Obesity Society's 2007 Annual Scientific Meeting 

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    Event date: 2007.10

    Language:English   Presentation type:Oral presentation (general)  

    Background
    Metabolic syndrome (MS) is a high risk state for the development of cardiovascular diseases and diabetes. In this study, adherence to healthy lifestyles were examined for their composite effect on the incidence of MS in Japan.
    Methods
    Men who did not have two or more MS components nor past medical history of cancer, cardiovascular diseases, diabetes, hypertension, and hyperlipidemia were followed for three years to the incidence of MS (n=1,688, mean age: 46.2 years old, mean body m

  18. Eating fast leads to obesity: Findings in Japanese non-diabetic men and women. International conference

    The North American Association of Study of Obesity 2005 Annual Scientific Meeting 

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    Event date: 2005.11

    Language:English   Presentation type:Poster presentation  

  19. Hypoadiponectinemia adds further inflamatory information to ordinary metabolic syndrome components. International conference

    European Society of Cardiology Congress (Stockholm, Sweden) 

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    Event date: 2005.10

    Language:English   Presentation type:Oral presentation (general)  

  20. Association between birth weight and white blood cell count in adulthood. International conference

    The XVII International scientific meeting of the international epidemiological association (Bangkok, Thailand) 

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    Event date: 2005.8

    Language:English   Presentation type:Poster presentation  

  21. Factors associated with insomnia among male civil servants in Japan. International conference

    The XVII International scientific meeting of the international epidemiological association (Bangkok, Thailand) 

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    Event date: 2005.8

    Language:English   Presentation type:Poster presentation  

  22. 心理的要因と乳がんリスクとの関連-大規模コホートによる検討-

    若井建志, 小嶋雅代, 八谷寛, 他10人(4番目).

    第15回日本疫学会( 大津) 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  23. 極めて健康な成人男性におけるadiponectinとC反応性蛋白の関連

    松下邦洋、八谷寛、玉腰浩司、他

    第40回日本循環器病予防学会(横浜) 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. 生活習慣病の家族歴と罹患集積状況との関連

    和田恵子、玉腰浩司、八谷寛、他.

    第40回日本循環器病予防学会(横浜) 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  25. 食べる速さと現在のBMI、20歳からのBMI変化量との関連

    大塚礼、玉腰浩司、八谷寛、他.

    第40回日本循環器病予防学会(横浜) 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  26. Simultaneous deterioration of several cardiovascular disease predictors in apparently healthy Japanese Men with metabolic syndrome.

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    Event date: 2005

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  27. 縦断的検討による「腹いっぱい食べる」習慣の推移と5年間のBMI変化量との関係.

    大塚礼、八谷寛、玉腰浩司、他5人(2番目).

    第15回日本疫学会(大津) 

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    Event date: 2005

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  28. 日本の事務職男性公務員における不眠と職業ストレスとの関連.

    村田千代栄、八谷寛、玉腰浩司、他4人(2番目).

    第15回日本疫学会(大津) 

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    Event date: 2005

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  29. 同一個人の追跡観察からえた経年的血圧測定値の多重レベル解析-階層構造データへの適用の利点-

    近藤高明, 渡邊ゆかり, 八谷寛, 他3人(4番目).

    第15回日本疫学会( 大津) 

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    Event date: 2005

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  30. Life Space and Mortality among the Functionally Independent Elderly. International conference

    132nd Annual Meeting of The American Public Health Association (Washington DC, USA) 

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    Event date: 2004.11

    Language:English   Presentation type:Oral presentation (general)  

  31. Perceived Mental Stress and Serum Leptin Concentration in Japanese Male Workers International conference

    The North American Association of Study of Obesity 2004 Annual Scientific Meeting (Las Vegas, USA) 

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    Event date: 2004.11

    Language:English   Presentation type:Poster presentation  

  32. Characteristics of Community Dwelling Homebound Elderly in Japan : Baseline Report. International conference

    132nd Annual Meeting of The American Public Health Association (Washington DC, USA) 

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    Event date: 2004.11

    Language:English   Presentation type:Oral presentation (general)  

  33. 7年間の追跡研究による地域在住高齢者の日常活動度と生命予後の関連について

    村田千代栄、近藤高明、八谷寛、他5人(6番目).

    愛知県公衆衛生研究会(大府) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  34. Power to detect prior myocardial infarction by ECG findings at health examination. International conference

    The 31st International Congress on Electrocardiology (Kyoto, Japan) 

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    Event date: 2004

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  35. メタボリックシンドロームにおけるアディポネクチンの意義.

    八谷寛

    第1回名古屋循環器疫学研究会(名古屋) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  36. 飲酒と女性乳がん罹患リスクの関連.

    林櫻松, 菊地正悟, 八谷寛, 他9人(5番目).

    第63回日本癌学会( 福岡) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  37. 喫煙と卵巣癌罹患リスクの関連.

    丹羽慶光, 西尾和子, 八谷寛, 他7人(5番目).

    第63回日本癌学会( 福岡) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  38. 生殖歴と乳がん罹患リスクとの関連.

    玉腰浩司, 豊嶋英明, 八谷寛, 他7人(8番目).

    第63回日本癌学会( 福岡) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  39. 脂質摂取と乳がん罹患リスクとの関連 日本における大規模コホート研究による検討.

    若井建志, 玉腰浩司, 八谷寛, 他8人(3番目).

    第63回日本癌学会( 福岡) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  40. 大豆製品摂取と乳がん罹患リスクとの関連.

    西尾和子、玉腰浩司、八谷寛、他7人(3番目).

    第63回日本癌学会(福岡) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  41. アディポネクチンは肥満度、インスリン抵抗性とは独立にMetabolic Syndromeに関連する

    八谷寛、玉腰浩司、大塚礼、近藤高明、豊嶋英明.

    第25回日本肥満学会(大阪) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  42. 各種肥満指標をmetabolic syndrome関連兆候のスクリーニングに用いた場合の有用性

    近藤高明、堀容子、八谷寛、玉腰浩司、豊嶋英明.

    第25回日本肥満学会(大阪) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  43. 職域男性における自覚的ストレスと血清レプチン濃度との関連

    大塚礼、八谷寛、玉腰浩司、他4人(2番目).

    第25回日本肥満学会(大阪) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  44. 人口寄与危険度割合を用いた職域集団での高血圧危険要因の評価 オッズ比との比較

    近藤高明、八谷寛、玉腰浩司、岡村愛.

    第77回産業衛生学会(名古屋) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  45. Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases.

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    Event date: 2004

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  46. 職域コホート研究における既往歴の妥当性(虚血性心疾患及び脳卒中)

    八谷寛、豊嶋英明、張恵明、他7人(1番目).

    第14回日本疫学会(山形) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  47. 長期の体重変動とMetabolic Syndromeとの関連

    張恵明、玉腰浩司、八谷寛、他8人(3番目).

    第14回日本疫学会(山形) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  48. 血清レプチン値と高血圧の関連

    和田恵子、八谷寛、間淵智子、他7人(2番目).

    第14回日本疫学会(山形) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  49. 自覚的ストレスと血清レプチン濃度との関連(男性における関連)

    大塚礼、八谷寛、玉腰浩司、他7人(2番目).

    第14回日本疫学会(山形) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  50. A nested case-control study of stomach cancer in relation to green tea consumption in Japan.

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    Event date: 2004

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  51. 前向き研究による血清Helicobacter pyloli、低pepsinogenと胃がんリスク.

    菊地正悟, 柳生聖子, 八谷寛, 他11人(5番目).

    第14回日本疫学会(山形) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  52. 職域集団における自己申告の身長、体重の妥当性

    和田恵子、玉腰浩司、八谷寛、他6人(8番目).

    第39回日本循環器病予防学会(旭川) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  53. 濃い味の好みと肥満との関連性に関する検討

    堀容子、大塚礼、八谷寛、他4人(4番目).

    第39回日本循環器病予防学会(旭川) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  54. 大塚礼、八谷寛、玉腰浩司、他4人(2番目). 職域コホートにおける血清レプチン濃度と生活習慣との関連

    第39回日本循環器病予防学会(旭川) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  55. 健診時心電図による冠動脈閉塞の既往に対する判定精度について

    張恵明、八谷寛、玉腰浩司、近藤高明、豊嶋英明.

    第19回心電情報ワークショップ(小田原) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  56. 健診時心電図の判読における留意点の抽出.

    張恵明、八谷寛、玉腰浩司、他11人(2番目).

    第49回東海公衆衛生学会(浜松) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  57. 長野県阿南町での下肢からの高齢者健康づくり事業の評価-下肢機能と測定形態の変化からみた介入効果-

    近藤高明、堀容子、八谷寛、他7人(4番目).

    第14回日本老年医学会東海地方会(名古屋) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  58. 「濃い味付けの好み」と心血管リスクファクターとの関連性についての検討

    堀容子、豊嶋英明、近藤高明、玉腰浩司、八谷寛.

    第13回日本疫学会(福岡) 

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    Event date: 2003

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  59. Self rated health after medical care utilization. International conference

    131st Annual Meeting of The American Public Health Association (San Franscisco, USA) 

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    Event date: 2003

    Language:English   Presentation type:Oral presentation (general)  

  60. 若年期からの体重変化、体重変動と血清レプチン濃度との関連

    八谷寛、玉腰浩司、吉田 勉、他3人(1番目).

    第24回日本肥満学会(千葉) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  61. 禁煙による食生活の変化と体重増加との関係

    八谷寛、太田尚寿、玉腰浩司、他8人(1番目).

    第38回日本循環器病予防学会(和歌山) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  62. 多変量解析を用いた高血圧と脳卒中のfamilial aggregationとcoaggregationの評価

    近藤高明、豊嶋英明、八谷寛、他4人(4番目).

    第38回日本循環器病予防学会(和歌山) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  63. 間淵智子、八谷寛、玉腰浩司、他6人(2番目). 愛知県職域コホートのベースラインデータ時におけるレプチンと白血球の関連

    第38回日本循環器病予防学会(和歌山) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  64. 日本人男性における体重変動と空腹時血清インスリン濃度との関連

    八谷寛、玉腰浩司、張 恵明、他8人(1番目).

    第13回日本疫学会(福岡) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  65. 体重変動と軽度C-reactive protein上昇との関連

    玉腰浩司、八谷寛、近藤高明、他8人(2番目).

    第13回日本疫学会(福岡) 

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    Event date: 2003

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  66. 扁平足における足裏の痛み・疲れ、および扁平足と肥満との関連性

    大塚礼、八谷寛、村田千代栄、他12人(2番目).

    第13回日本疫学会(福岡) 

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    Event date: 2003

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  67. 甘粛省天水市奥地の衛生院と小学校の視察に基づいた中国辺境地の衛生と教育事情に関する一活動報告

    石川美由紀、近藤高明、八谷寛、他5人(4番目).

    第48回東海公衆衛生学会(津) 

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    Event date: 2002

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  68. インスリン濃度と危険因子集積の検討

    八谷寛、玉腰浩司、吉田 勉、他2人(1番目).

    第23回日本肥満学会(京都) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  69. 簡易食事調査法の再現性と妥当性

    八谷寛、大脇淳子、小出浩司、他5人(1番目).

    第12回日本疫学会(東京) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  70. 成人男性集団における危険要因の重積と血清レプチン値、インシュリン値との関連

    近藤高明、八谷寛、玉腰浩司、堀容子、豊嶋英明.

    第12回日本疫学会(東京) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  71. 炎症マーカーであるCRPとMetabolic Syndromeとの関連

    玉腰浩司、八谷寛、近藤高明、他6人(2番目).

    第12回日本疫学会(東京) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  72. 高齢者の社会関係は生命予後に影響を与えるか?

    村田千代栄、近藤高明、八谷寛、他5人(5番目).

    第61回日本公衆衛生学会(大宮) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  73. 地域における高齢者の健康に関する研究II. -高齢者の閉じこもりに関する追跡調査を中心に-

    石川美由紀、近藤高明、八谷寛、他7人(4番目).

    第48回東海公衆衛生学会(津) 

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    Event date: 2002

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  74. 高齢者の社会関係が生命予後に与える影響について

    村田千代栄、近藤高明、八谷寛、他5人(5番目).

    第48回東海公衆衛生学会(津) 

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    Event date: 2002

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  75. 高齢者における肥満と扁平足及び外反母趾との関連

    大塚礼、八谷寛、村田千代栄、他8人(2番目).

    第48回東海公衆衛生学会(津) 

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    Event date: 2002

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  76. 中国辺境地の衛生と教育事情I-甘粛省天水市奥地の衛生院と小学校の視察をもとに-

    石川美由紀、張恵明、八谷寛、豊嶋英明.

    第17回日本国際保健医療学会(神戸) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  77. 地域における高齢者の閉じこもりに関する研究

    石川美由紀、近藤高明、八谷寛、他4人(4番目).

    第61回日本公衆衛生学会(大宮) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  78. 職域における循環器疾患予防.

    八谷寛、豊嶋英明、近藤高明、堀容子、玉腰浩司.

    平成13年度日本産業衛生学会東海地方会(名古屋) 

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    Event date: 2001

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  79. Primary carer in household with less level of Informal Support Network is more depressive. International conference

    International Society for Quality of Life Research Pan-Pacific Conference (Tokyo, Japan) 

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    Event date: 2001

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  80. Long-term weight gain predicts clustering of cardiac risk factors. International conference

    The 5th International Conference on Preventive Cardiology (Osaka, Japan) 

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    Event date: 2001

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  81. A cross-sectional study on factors related to hypertension with special reference to gender difference in Japanese workers. International conference

    The 5th International Conference on Preventive Cardiology (Osaka, Japan) 

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    Event date: 2001

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  82. Family history and the risk of stomach cancer death in Japan: Differences by age and sex. International conference

    The 3rd Asian-Pacific Congress of Epidemiology (Kitakyushu, Japan) 

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    Event date: 2001

    Language:English  

  83. A prospecive study of stomach cancer and its relation to green tea consumption in Japan. International conference

    The 3rd Asian-Pacific Congress of Epidemiology (Kitakyushu, Japan) 

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    Event date: 2001

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  84. 20代からの体重変化と脳・心血管疾患リスクファクター集積との関連

    八谷寛、玉腰浩司、堀 容子、他7人(1番目).

    第11回日本疫学会(つくば) 

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    Event date: 2001

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  85. 体重変動とインスリン濃度との関連

    八谷寛、玉腰浩司、近藤高明、他3人(1番目).

    第22回日本肥満学会(前橋) 

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    Event date: 2001

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  86. 多施設検査データ統合疫学研究における外部精度管理調査結果の利用

    八谷寛、玉腰浩司、近藤高明、他7人(1番目).

    第46回東海公衆衛生学会(岐阜) 

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    Event date: 2000

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  87. 職域コホートのベースラインデータにおける諸種生活習慣病と食習慣の関係

    八谷寛、玉腰浩司、堀 容子、他8人(1番目).

    第10回日本疫学会総会(米子) 

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    Event date: 2000

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  88. Possible change in dietary pattern with awareness of elevated serum cholesterol level-an indirect association seen in a cross-sectional study. International conference

    The XV International scientific meeting of the international epidemiological association (Florence, Italy) 

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    Event date: 1999

    Language:English   Presentation type:Poster presentation  

  89. 職域コホートを用いた生活習慣病の発症に関する調査 -食習慣と血清脂 質の関係-

    八谷寛、堀容子、豊嶋英明他.

    第9回日本疫学会総会(名古屋) 

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    Event date: 1999

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  90. 障害調整生存年DALY(Disability-Adjusted Life Year)による日本の総疾病負担の推定

    八谷寛、福田吉治、長谷川敏彦、田端航也他.

    第69回日本衛生学会総会(千葉) 

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    Event date: 1999

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  91. 新興再興感染症の現状と日本の状況(preparedness)

    八谷寛、豊嶋英明、宮尾克他.

    第13回日本国際保健医療学会(大阪) 

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    Event date: 1998

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  92. 発展途上国における下痢症の現状とその対策について

    八谷寛

    第39回社会医学研究会総会(名古屋) 

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    Event date: 1998

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 19

  1. 多目的コホートに基づくが ん予防など健康の維持・増進に役立つエビデンスの構築に関する研究 International coauthorship

    Grant number:2020-J-4  2020.5 - 2021.3

    国立がん研究センター研究開発費 

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    Authorship:Coinvestigator(s)  Grant type:Other

    Grant amount:\250000

  2. 生涯にわたる循環器疾患の個人リスクおよび集団リスクの評価ツールの開発及び臨床応用のための研究

    Grant number:20316311  2020.4

    厚生労働科学研究費補助金  循環器疾患・糖尿病等生活習慣病対策総合研究事業

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    Grant type:Competitive

    Grant amount:\750000 ( Direct Cost: \750000 )

  3. 涯にわたる循環器疾患の個人リスクおよび集団のリスク評価ツールの開発を目的とした大規模コホート統合研究

    Grant number:17933083  2017.4 - 2020.3

    厚生労働科学研究費補助金  循環器疾患・糖尿病等生活習慣病対策総合研究事業

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    Authorship:Coinvestigator(s) 

    Grant amount:\4650000 ( Direct Cost: \4650000 )

  4. 保健関連ポストMDG課題としてのNoncommunicable Disease (NCD)-オセアニア・南アジア・アフリカにおけるNCD対策推進のための学際的研究 International coauthorship

    Grant number:15545398  2015.4 - 2018.3

    日本医療研究開発機構研究費  地球規模保健課題解決推進のための研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  5. 生活習慣病予防のための宿泊を伴う効果的な保健指導プログラムの開発に関する研究

    Grant number:15652746  2015.4 - 2017.3

    循環器疾患・糖尿病等生活習慣病対策実用化研究事業  循環器疾患・糖尿病等生活習慣病対策実用化研究事業(委託事業)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  6. 循環器疾患における集団間の健康格差の実態把握とその対策を目的とした大規模コホート共同研究

    Grant number:14427346  2014.4 - 2017.3

    厚生労働科学研究費補助金  循環器疾患・糖尿病等生活習慣病対策政策研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4000000 ( Direct Cost: \4000000 )

  7. 生活習慣病予防のための宿泊を伴う効果的な保健指導プログラムの開発に関する研究

    Grant number:14533117  2014.4 - 2015.3

    厚生労働科学研究費補助金  循環器疾患・糖尿病等生活習慣病対策実用化研究事業(委託事業)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  8. 脂肪細胞機能調節性マイクロRNAと肝脂肪蓄積との関連

    2014

    学術研究振興資金 

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    Grant amount:\3000000

  9. 東アジア、オセアニアにおける生活習慣病対策推進のための学際的研究 International coauthorship

    Grant number:13802126  2012.4 - 2015.3

    厚生労働科学研究費補助金  地球規模保健課題解決推進のための行政施策に関する研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  10. 潜在性動脈硬化と新規血清指標の疫学研究

    2012

    研究推進特別奨励金 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4000000 ( Direct Cost: \4000000 )

  11. 一般集団におけるMagnetic Resonance Spectroscopyによる異所性脂肪蓄積定量化-生活習慣と脂肪分布異常から見た肥満関連代謝異常の疫学的病態解明-

    2007 - 2008

    千代田健康開発事業団 

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    Grant type:Competitive

  12. メタボリックシンドローム予防における血清アディポネクチン濃度測定の意義

    2006

    名古屋公衆医学研究所 

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    Grant type:Competitive

  13. アディポネクチンと代謝異常症候群との関連

    2004 - 2006

    上原記念生命科学財団研究奨励金 

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    Grant type:Competitive

  14. 性差を考慮した生活習慣病発症メカニズムの疫学的病態解明

    2004 - 2005

    愛知健康増進財団 

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    Grant type:Competitive

  15. 生活習慣病発症予防に関する職域コホート研究-職場におけるストレスと炎症マーカーとの関連-

    2004 - 2005

    公益信託動脈硬化予防研究助成金 

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    Grant type:Competitive

  16. 肥満者における心血管疾患発症の過剰リスクを説明する新しい軸-レプチンと炎症反応の直接的関連-

    2003 - 2005

    財団法人健康管理事業団 

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    Grant type:Competitive

  17. レプチン抵抗性に基づく肥満の疫学的病態解明

    2003 - 2004

    財団法人明治生命厚生事業団 

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    Grant type:Competitive

  18. 生活習慣病発症予防に関する職域コホート研究-血清レプチン値と体重変化との関連-

    2003 - 2004

    公益信託動脈硬化予防研究助成金 

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    Grant type:Competitive

  19. 生活習慣病発症予防に関する職域コホート研究-インスリン濃度と危険因子集積の検討-

    2002 - 2003

    公益信託動脈硬化予防研究助成金 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 28

  1. Worksite-based cohort study on risk factors for non-communicable disease in Japan

    Grant number:22390133  2010.4 - 2014.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

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    Authorship:Principal investigator  Grant type:Competitive

    We carried out a worksite-based cohort study in an attempt to identify risk factors and novel markers of cardiovascular disease in recent Japanese population. Civil servants of a local government located in central Japan (n=6,648) were followed, and 59 incident coronary heart diseases, 47 strokes, 430 diabetes, and 1,599 hypertension were ascertained during the entire observation period (approximately 10 years). Overweight, hypertension, and current smoking were significantly positively associated with higher incidence of cardiovascular disease. Low adiponectin and high CRP blood levels, current smoking, breakfast skipping, and positive family history were associated with higher diabetes incidence. Novel biomarkers were obtained by AlphaLISA. We also performed questionnaire survey and collected additional blood and urine sample for the remaining and new cohort participants (n=6,046).

  2. MRSによる異所性脂肪蓄積定量化-有効な生活習慣病予防に向けて-

    Grant number:20790438  2008.4

    日本学術振興会  科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator  Grant type:Competitive

  3. アディポサイトカインによる生活習慣病予防パラダイムの展開

    Grant number:17790384  2005 - 2007.3

    日本学術振興会  科学研究費補助金  若手研究(B)

    八谷 寛

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    Authorship:Principal investigator  Grant type:Competitive

  4. レプチン抵抗性に基づく肥満及びリスクファクター集積の疫学的病態モデル構築

    Grant number:15689011  2003 - 2004

    科学研究費補助金  若手研究(A),課題番号:

    八谷 寛

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    Authorship:Principal investigator  Grant type:Competitive

    (1)健康男性767人の5年間の体重変化とベースライン時血清レプチン値との関連をベースライン時のBMIと年齢を調整して調べたところ、両者に有意な関連は認められなかった。ヒトにおけるレプチン抵抗性の存在を示した結果であると考えられた。(2)ベースライン血清レプチン値と血圧値との関連をインスリン抵抗性のHOMA指数を考慮して検討したところ(男性2,017名)、インスリン抵抗性のない非肥満者においてのみ血圧値とレプチン値に有意な関連性が認められた。また、この関連性は拡張期血圧において特に強かった。レプチンの交感神経系亢進作用が示唆された。(3)白血球数を従属変数、レプチン値、年齢、BMI、身体活動量、飲酒習慣、喫煙習慣を独立変数とした重回帰分析において(男性1,082人、女性200名)、レプチン値と白血球数の間に有意で独立した関連が認められた(男性:標準化β=0.17、P<0.001、女性:標準化β=0.31、P<0.001)。肥満者でしばしば認められる白血球数の上昇は肥満者における高レプチン血症によって引き起こされているかもしれないことが示唆された。(4)40歳代の健康男性625名を対象とした分析において、個人ごとの体重変化を年齢に対して回帰させた直線周囲の標準偏差(Root-mean-square-error : RMSE)を用いて算出した20歳代からの体重変動と血清レプチン値との間には肥満度や体重変化の傾きと独立した有意な関連が認められ、レプチン値の個人差が長期的な体重変動によって規定されている可能性があることが示唆された。(