Updated on 2024/10/21

写真a

 
YATSUYA Hiroshi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor
Contact information
メールアドレス
External link

Degree 1

  1. PhD ( 2003.1   Nagoya University ) 

Research Interests 11

  1. prevention

  2. 循環器疾患

  3. 肥満

  4. 生活習慣病

  5. 疫学

  6. 公衆衛生

  7. 糖尿病

  8. cardiovascular diseases

  9. cohort studies

  10. non-communicable diseases

  11. obesity

Research Areas 5

  1. Life Science / Hygiene and public health (non-laboratory)

  2. Life Science / Medical management and medical sociology

  3. Life Science / Hygiene and public health (non-laboratory)

  4. Life Science / Hygiene and public health (laboratory)

  5. Life Science / Hygiene and public health (laboratory)

Current Research Project and SDGs 1

  1. 生活習慣病の疫学研究

Research History 10

  1. 名古屋大学大学院医学系研究科   国際保健医療学・公衆衛生学   教授

    2020.10

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    Country:Japan

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  2. 藤田保健衛生大学医学部(藤田医科大学)   公衆衛生学   教授

    2012.7 - 2021.3

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    Country:Japan

  3. Fujita Health University   School of Medicine   Professor

    2012.7 - 2021.3

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  4. 名古屋大学 大学院医学系研究科   国際保健医療学・公衆衛生学分野   准教授

    2011.4 - 2012.6

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    Country:Japan

  5. 名古屋大学 大学院医学系研究科   公衆衛生学分野   准教授

    2010.9 - 2011.3

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    Country:Japan

  6. Visiting Associate Professor, University of Minnesota Division of Epidemiology and Community Health

    2008.9 - 2010.8

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    Country:United States

  7. Associate Professor, Nagoya University Graduate School of Medicine

    2007.4 - 2010.8

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    Country:Japan

  8. Associate Professor, Nagoya University Graduate School of Medicine

    2004.6 - 2007.3

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    Country:Japan

  9. Assistant Professor, Nagoya University Graduate School of Medicine

    2000.5 - 2004.6

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    Country:Japan

  10. Handa Municipal Hospital

    1996.5 - 1997.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medicine   Program in Social Medicine

    1997.4 - 2000.4

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 1996.3

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    Country: Japan

Professional Memberships 21

  1. Japan Epidemiological Association

  2. Japanese Society of Public Health

  3. Japan Society for Occupational Health

  4. Japanese Association for Cerebro-cardiovascular Disease Control

  5. 日本学校保健学会

  6. 東海公衆衛生学会

  7. 日本社会医学会

  8. Japan Society for the Study of Obesity

  9. 日本動脈硬化学会

  10. The Japanese Circulation Society

  11. International Epidemiological Association

  12. American Heart Association

  13. Japan Human data Society of Diabetes and related diseases

    2017.12

  14. 東海公衆衛生学会

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  15. JAPAN SOCIETY FOR THE STUDY OF OBESITY

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  16. 日本産業衛生学会

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  17. 日本循環器病予防学会

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  18. THE JAPANESE ASSOCIATION OF SCHOOL HEALTH

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  19. 日本動脈硬化学会

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  20. JAPANESE SOCIETY OF PUBLIC HEALTH

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  21. 日本疫学会

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Committee Memberships 28

  1. 日本学術会議   連携会員  

    2014.10   

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    Committee type:Government

    第23期生活習慣病対策分科会幹事(2014-2017)
    第24期生活習慣病対策分科会委員長(2017-2020)
    第25期生活習慣病対策分科会委員長(2020-2023)

  2. 日本循環器病予防学会   常任理事  

    2023.4   

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    Committee type:Academic society

  3. 愛知県国民健康保険団体連合会保健事業支援・評価委員会   委員  

    2021.4   

  4. 日本産業衛生学会職場ストレス研究会   代表世話人  

    2021.4   

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    Committee type:Academic society

  5. 日本公衆衛生学会モニタリング・レポート委員会   委員(生活習慣病・公衆栄養グループ)  

    2020.4   

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    Committee type:Academic society

  6. 内閣府食品安全委員会   ビスフェノールAの健康影響に関する調査事業検討会委員  

    2019.8 - 2020.3   

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    Committee type:Government

  7. 岩倉市健幸づくり推進委員会   委員長  

    2019.5   

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    Committee type:Municipal

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  8. 東海公衆衛生学会   理事  

    2018.4   

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    Committee type:Academic society

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  9. 日本学術会議 生活習慣病対策分科会   委員長  

    2018.2 - 2023.9   

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    Committee type:Government

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  10. 愛知県医師会   地域医療政策研究機構委員会・委員  

    2018.1   

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    Committee type:Other

  11. 日本疫学会 広報委員会   委員  

    2018.1   

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    Committee type:Academic society

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  12. Journal of Epidemiology   編集委員  

    2017.1   

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    Committee type:Academic society

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  13. Journal of Epidemiology   Associate Editor  

    2017.1   

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    Committee type:Academic society

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  14. Fujita Medical Journal   編集委員長  

    2015.2   

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    Committee type:Academic society

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  15. Fujita Medical Journal   Editor-in-Chief  

    2015.2   

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    Committee type:Academic society

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  16. 日本学術会議   連携会員  

    2014.10   

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    Committee type:Government

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  17. Science Council of Japan   member  

    2014.10   

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    Committee type:Government

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  18. 東海公衆衛生雑誌   編集委員  

    2014.10 - 2017.7   

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    Committee type:Academic society

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  19. 日本公衆衛生学会   評議員  

    2014.7   

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    Committee type:Academic society

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  20. 日本疫学会   評議員  

    2013.1   

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    Committee type:Academic society

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  21. 日本産業衛生学会   代議員  

    2012.11   

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    Committee type:Academic society

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  22. Journal of Atherosclerosis and Thrombosis   編集委員  

    2012.10   

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    Committee type:Academic society

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  23. Journal of Atherosclerosis and Thrombosis   Editor  

    2012.10   

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    Committee type:Academic society

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  24. 東海公衆衛生学会   評議員  

    2012.4 - 2018.3   

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    Committee type:Academic society

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  25. 日本循環器病予防学会(循環器管理研究協議会)   評議員  

    2010.5   

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    Committee type:Academic society

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  26. 農林水産省   「食事バランスガイド」を活用した「日本型食生活」の効果を科学的に検証 する事業、検討会委員  

    2008.4 - 2009.3   

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    Committee type:Government

  27. 国立研究開発法人 国立長寿医療研究センター   倫理・利益相反委員会 委員  

       

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    Committee type:Other

  28. 日本循環器病予防学会   常任理事  

       

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    Committee type:Academic society

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Awards 4

  1. Young Investigator Award

    2007.1   Japan Epidemiological Association  

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    Country:Japan

  2. Young Investigator Award

    2007.7   Japan Society for Social Medicine  

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    Country:Japan

  3. Journal of Epidemiology ベストレビューアー賞

    2016.1   日本疫学会  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  4. Journal of Epidemiology ベストレビューアー賞

    2012.1   日本疫学会  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

 

Papers 338

  1. Global, regional, and national burden of stroke and its risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 Reviewed International coauthorship International journal

    Valery L Feigin, Melsew Dagne Abate, Yohannes Habtegiorgis Abate, Samar Abd ElHafeez, Foad Abd-Allah, Ahmed Abdelalim, Atef Abdelkader, Michael Abdelmasseh, Sherief Abd-Elsalam, Parsa Abdi, Arash Abdollahi, Meriem Abdoun, Rami Abd-Rabu, Deldar Morad Abdulah, Auwal Abdullahi, Mesfin Abebe, Roberto Ariel Abeldaño Zuñiga, E S Abhilash, Olugbenga Olusola Abiodun, Olumide Abiodun, Rahim Abo Kasem, Richard Gyan Aboagye, Mohamed Abouzid, Lucas Guimarães Abreu, Woldu Aberhe Abrha, Dariush Abtahi, Samir Abu Rumeileh, Ahmed Abualhasan, Hasan Abualruz, Eman Abu-Gharbieh, Hana J Abukhadijah, Niveen ME Abu-Rmeileh, Salahdein Aburuz, Ahmed Abu-Zaid, Juan Manuel Acuna, Denberu Eshetie Adane, Mesafint Molla Adane, Isaac Yeboah Addo, Rufus Adesoji Adedoyin, Oyelola A Adegboye, Victor Adekanmbi, Kishor Adhikari, Qorinah Estiningtyas Sakilah Adnani, Saryia Adra, Leticia Akua Adzigbli, Abdelrahman Yousry Afify, Aanuoluwapo Adeyimika Afolabi, Fatemeh Afrashteh, Muhammad Sohail Afzal, Saira Afzal, Shahin Aghamiri, Williams Agyemang-Duah, Bright Opoku Ahinkorah, Aqeel Ahmad, Muayyad M Ahmad, Sajjad Ahmad, Shahzaib Ahmad, Tauseef Ahmad, Amir Mahmoud Ahmadzade, Ali Ahmed, Ayman Ahmed, Haroon Ahmed, Syed Anees Ahmed, Marjan Ajami, Budi Aji, Essona Matatom Akara, Rufus Olusola Akinyemi, Mohammed Ahmed Akkaif, Ashley E Akrami, Salah Al Awaidy, Hanadi Al Hamad, Syed Mahfuz Al Hasan, Mohammad Al Qadire, Omar Al Ta'ani, Yazan Al-Ajlouni, Samer O Alalalmeh, Tariq A Alalwan, Ziyad Al-Aly, Rasmieh Mustafa Al-amer, Wafa A Aldhaleei, Mohammed S Aldossary, Seyedeh Yasaman Alemohammad, Bassam Al-Fatly, Adel Ali Saeed Al-Gheethi, Fadwa Naji Alhalaiqa, Maryam Alharrasi, Abid Ali, Mohammed Usman Ali, Rafat Ali, Syed Shujait Ali, Waad Ali, Akram Al-Ibraheem, Sheikh Mohammad Alif, Syed Mohamed Aljunid, Wael Almahmeed, Sabah Al-Marwani, Mahmoud A Alomari, Jordi Alonso, Jaber S Alqahtani, Rajaa M Mohammad Al-Raddadi, Ahmad Alrawashdeh, Mohammed A Alsabri, Najim Z Alshahrani, Zaid Altaany, Awais Altaf, Alaa B Al-Tammemi, Diala Altwalbeh, Nelson Alvis-Guzman, Hassan Alwafi, Mohammad Al-Wardat, Yaser Mohammed Al-Worafi, Hany Aly, Safwat Aly, Mohammad Sharif Ibrahim Alyahya, Karem H Alzoubi, Walid Adnan Al-Zyoud, Reza Amani, Prince M Amegbor, Tewodros Getnet Amera, Tarek Tawfik Amin, Alireza Amindarolzarbi, Sohrab Amiri, Hubert Amu, Dickson A Amugsi, Ganiyu Adeniyi Amusa, Robert Ancuceanu, Deanna Anderlini, Dhanalakshmi Angappan, Abhishek Anil, Mohammed Tahir Tahir Ansari, Alireza Ansari-Moghaddam, Rockson Ansong, Saeid Anvari, Saleha Anwar, Sumadi Lukman Anwar, Ekenedilichukwu Emmanuel Anyabolo, Anayochukwu Edward Anyasodor, Geminn Louis Carace Apostol, Francis Appiah, Muhammad Aqeel, Jalal Arabloo, Razman Arabzadeh Bahri, Mosab Arafat, Aleksandr Y Aravkin, Ali Ardekani, Demelash Areda, Brhane Berhe Aregawi, Getnet Mesfin Aregu, Olatunde Aremu, Hidayat Arifin, Johan Ärnlöv, Anton A Artamonov, Judie Arulappan, Umesh Raj Aryal, Zahra Aryan, Akram M Asbeutah, Mulusew A Asemahagn, Mulu Tiruneh Asemu, Mohammad Asghari-Jafarabadi, Mubarek Yesse Ashemo, Tahira Ashraf, Armin Aslani, Haftu Asmerom Asmerom, Thomas Astell-Burt, Seyyed Shamsadin Athari, Prince Atorkey, Maha Moh'd Wahbi Atout, Alok Atreya, Avinash Aujayeb, Marcel Ausloos, Abolfazl Avan, Hamzeh Awad, Adedapo Wasiu Awotidebe, Lemessa Assefa A Ayana, Setognal Birara Aychiluhm, Amdehiwot A Aynalem, Zewdu Bishaw Aynalem, Sina Azadnajafabad, Hiva Azami, Shahkaar Aziz, Ahmed Y Azzam, Abraham Samuel Babu, Giridhara Rathnaiah Babu, Muhammad Badar, Ashish D Badiye, Pegah Bahrami Taghanaki, Saeed Bahramian, Ruhai Bai, Atif Amin Baig, Shankar M Bakkannavar, Abdulaziz T Bako, Ovidiu Constantin Baltatu, Kiran Bam, Maciej Banach, Morteza Banakar, Soham Bandyopadhyay, Palash Chandra Banik, Kannu Bansal, Yanping Bao, Miguel A Barboza, Mainak Bardhan, Noel C Barengo, Suzanne Lyn Barker-Collo, Till Winfried Bärnighausen, Hiba Jawdat Barqawi, Amadou Barrow, Lingkan Barua, Azadeh Bashiri, Hameed Akande Bashiru, Afisu Basiru, Mohammad-Mahdi Bastan, Sanjay Basu, Saurav Basu, Kavita Batra, Ahmet Begde, Babak Behnam, Amir Hossein Behnoush, Melesse B Y Belayneh, Michael Belingheri, Umar Muhammad Bello, Derrick A Bennett, Isabela M Bensenor, Fentaw Tadese Berhe, Amiel Nazer C Bermudez, Habtamu B B Beyene, Kebede A Beyene, Devidas S Bhagat, Akshaya Srikanth Bhagavathula, Neeraj Bhala, Ashish Bhalla, Nikha Bhardwaj, Pankaj Bhardwaj, Sonu Bhaskar, Ajay Nagesh Bhat, Vivek Bhat, Gurjit Kaur Bhatti, Jasvinder Singh Singh Bhatti, Mohiuddin Ahmed Bhuiyan, Subarna Bhusal, Boris Bikbov, Cem Bilgin, Antonio Biondi, Keralem Anteneh Bishaw, Atanu Biswas, Bijit Biswas, Trupti Bodhare, Eyob Ketema Bogale, Archith Boloor, Milad Bonakdar Hashemi, Aime Bonny, Berrak Bora Basara, Hamed Borhany, Samuel Adolf Bosoka, Souad Bouaoud, Abdelhakim Bouyahya, Edward J Boyko, Marija M Bozic, Dejana Braithwaite, Susanne Breitner, Hermann Brenner, Gabrielle Britton, Andre R Brunoni, Dana Bryazka, Raffaele Bugiardini, Lemma N Bulto, Katrin Burkart, Yasser Bustanji, Zahid A Butt, Florentino Luciano Caetano dos Santos, Luis Alberto Cámera, Luciana Aparecida Campos, Ismael R Campos-Nonato, Fan Cao, Angelo Capodici, Rosario Cárdenas, Sinclair Carr, Giulia Carreras, Andre F Carvalho, Felix Carvalho, Joao Mauricio Castaldelli-Maia, Carlos A Castañeda-Orjuela, Giulio Castelpietra, Alberico L Catapano, Maria Sofia Cattaruzza, Luca Cegolon, Francieli Cembranel, Edina Cenko, Ester Cerin, Joshua Chadwick, Chiranjib Chakraborty, Sandip Chakraborty, Jeffrey Shi Kai Chan, Rama Mohan Chandika, Eeshwar K Chandrasekar, Gashaw Sisay Chanie, Vijay Kumar Chattu, Anis Ahmad Chaudhary, Akhilanand Chaurasia, Haowei Chen, Mingling Chen, Simiao Chen, Gerald Chi, Fatemeh Chichagi, Ritesh Chimoriya, Patrick R Ching, Abdulaal Chitheer, So Mi Jemma Cho, Dong-Woo Choi, Bryan Chong, Chean Lin Chong, Hitesh Chopra, Sonali Gajanan Choudhari, Rahul Choudhary, Dinh-Toi Chu, Isaac Sunday Chukwu, Sheng-Chia Chung, Zinhle Cindi, Iolanda Cioffi, Rebecca M Cogen, Alyssa Columbus, Simona Costanzo, Rosa A S Couto, Michael H Criqui, Natalia Cruz-Martins, Silvia Magali Cuadra-Hernández, Alanna Gomes da Silva, Sriharsha Dadana, Omid Dadras, Xiaochen Dai, Koustuv Dalal, Lachlan L Dalli, Giovanni Damiani, Emanuele D'Amico, Lalit Dandona, Rakhi Dandona, Amira Hamed Darwish, Saswati Das, Mohsen Dashti, Mohadese Dashtkoohi, Mohammad Dashtkoohi, Maedeh Dastmardi, Kairat Davletov, Vanessa De la Cruz-Góngora, Sean DeAngelo, Aklilu Tamire Debele, Shayom Debopadhaya, Ivan Delgado-Enciso, Berecha Hundessa Demessa, Andreas K Demetriades, Edgar Denova-Gutiérrez, Emina Dervišević, Hardik Dineshbhai Desai, Aragaw Tesfaw Desale, Fikreab Desta, Vinoth Gnana Chellaiyan Devanbu, Devananda Devegowda, Syed Masudur Rahman Dewan, Amol S Dhane, Meghnath Dhimal, Vishal R Dhulipala, Michael J Diaz, Mengistie Diress, Milad Dodangeh, Phidelia Theresa Doegah, Sushil Dohare, Mohamed Fahmy Doheim, Klara Georgieva Dokova, Deepa Dongarwar, Mario D'Oria, Ojas Prakashbhai Doshi, Rajkumar Prakashbhai Doshi, Abdel Douiri, Robert Kokou Dowou, Ashel Chelsea Dsouza, Haneil Larson Dsouza, Viola Savy Dsouza, Bruce B Duncan, Andre Rodrigues Duraes, Arkadiusz Marian Dziedzic, Michael Ekholuenetale, Ibrahim Farahat El Bayoumy, Maysaa El Sayed Zaki, Iffat Elbarazi, Faris El-Dahiyat, Islam Y Elgendy, Muhammed Elhadi, Waseem El-Huneidi, Mohamed A Elmonem, Adel B Elmoselhi, Chadi Eltaha, Theophilus I Emeto, Christopher Imokhuede Esezobor, Negin Esfandiari, Zahra Esmaeili, Francesco Esposito, Mohammad Etoom, Natalia Fabin, Ibtihal Fadhil, Adeniyi Francis Fagbamigbe, Omotayo Francis Fagbule, Shahriar Faghani, Ayesha Fahim, Ildar Ravisovich Fakhradiyev, Luca Falzone, Mohammad Fareed, Jawad Fares, Carla Sofia e Sá Farinha, MoezAlIslam Ezzat Mahmoud Faris, Pawan Sirwan Faris, Mohsen Farjoud Kouhanjani, Andre Faro, Hossein Farrokhpour, Abidemi Omolara Fasanmi, Nelsensius Klau Fauk, Patrick Fazeli, Timur Fazylov, Alireza Feizkhah, Ginenus Fekadu, Xiaoqi Feng, Seyed-Mohammad Fereshtehnejad, Pietro Ferrara, Nuno Ferreira, Getahun Fetensa, Bikila Regassa Feyisa, Florian Fischer, Luisa S Flor, Kristen Marie Foley, Ana Catarina Fonseca, Roham Foroumadi, Behzad Foroutan, Daniela Fortuna, Matteo Foschi, Richard Charles Franklin, Ni Kadek Yuni Fridayani, Sridevi G, Peter Andras Gaal, Abhay Motiramji Gaidhane, Abduzhappar Gaipov, Yaseen Galali, Silvano Gallus, Aravind P Gandhi, Balasankar Ganesan, Danijela Gasevic, Prem Gautam, Rupesh K Gautam, Miglas Welay Gebregergis, Mesfin Gebrehiwot, Kebre Gebrekirstos Gebrekidan, Lemma Getacher, Genanew K Getahun, Molla Getie, Delaram J Ghadimi, Fataneh Ghadirian, Amir Ghaffari Jolfayi, Mansour Ghafourifard, Mohammad-Reza Ghasemi, Afsaneh Ghasemzadeh, Ramy Mohamed Ghazy, Ehsan Gholami, Zainab Gholami, Sherief Ghozy, Stefano Giannoni Luza, Jaleed Ahmed Gilani, Tiffany K Gill, Richard F Gillum, Ebisa Zerihun Gindaba, Elena V Gnedovskaya, Amit Goel, Mohamad Goldust, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Philimon N Gona, Giuseppe Gorini, Alessandra C Goulart, Barbara Niegia Garcia Goulart, Mahdi Gouravani, Michal Grivna, Giuseppe Grosso, Ashna Grover, Shi-Yang Guan, Giovanni Guarducci, Avirup Guha, Stefano Guicciardi, Snigdha Gulati, Damitha Asanga Gunawardane, Cui Guo, Zhifeng Guo, Anish Kumar Gupta, Bhawna Gupta, Mohak Gupta, Rahul Gupta, Rajat Das Gupta, Rajeev Gupta, Sapna Gupta, Farrokh Habibzadeh, Najah R Hadi, Mohammad Haghani Dogahe, Hamed Haghi-Aminjan, Dariush Haghmorad, Arvin Haj-Mirzaian, Aram Halimi, Nadia M Hamdy, Samer Hamidi, Erin B Hamilton, Asif Hanif, Nasrin Hanifi, Graeme J Hankey, Md Abdul Hannan, Zaim Anan Haq, Arief Hargono, Netanja I Harlianto, Josep Maria Haro, Eka Mishbahatul Marah Has, Ahmed I Hasaballah, Ikramul Hasan, Md Saquib Hasnain, Ikrama Hassan, Mahgol Sadat Hassan Zadeh Tabatabaei, Johannes Haubold, Rasmus J Havmoeller, Simon I Hay, Youssef Hbid, Jeffrey J Hebert, Omar E Hegazi, Mohammad Heidari, Mehdi Hemmati, Demisu Zenbaba Heyi, Kamal Hezam, Yuta Hiraike, Nguyen Quoc Hoan, Ramesh Holla, Nobuyuki Horita, Md Mahbub Hossain, Hassan Hosseinzadeh, Mehdi Hosseinzadeh, Ahmad Hosseinzadeh Adli, Mihaela Hostiuc, Sorin Hostiuc, Ben Hu, Chengxi Hu, Junjie Huang, Ayesha Humayun, Salman Hussain, Le Duc Huy, Hong-Han Huynh, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Nayu Ikeda, Adalia Ikiroma, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Mohammad Tarique Imam, Mustapha Immurana, Leeberk Raja Inbaraj, Muhammad Iqhrammullah, Arnaud Iradukunda, Lalu Muhammad Irham, Md Rabiul Islam, Faisal Ismail, Nahlah Elkudssiah Ismail, Hiroyasu Iso, Gaetano Isola, Ramaiah Itumalla, Masao Iwagami, Chidozie Declan CD Iwu, Vinothini J, Jalil Jaafari, Louis Jacob, Abdollah Jafarzadeh, Haitham Jahrami, Akhil Jain, Nityanand Jain, Ammar Abdulrahman Jairoun, Abhishek Jaiswal, Mihajlo Jakovljevic, Reza Jalilzadeh Yengejeh, Balamurugan Janakiraman, Abubakar Ibrahim Jatau, Sathish Kumar Jayapal, Shubha Jayaram, Sun Ha Jee, Jayakumar Jeganathan, Mihretu Jegnie, Alelign Tasew Jema, Bijay Mukesh Jeswani, Angeline Jeyakumar, Anil K Jha, Ravi Prakash Jha, Zixiang Ji, Heng Jiang, Shuai Jin, Yingzhao Jin, Mohammad Jokar, Jost B Jonas, Tamas Joo, Jobinse Jose, Nitin Joseph, Charity Ehimwenma Joshua, Farahnaz Joukar, Jacek Jerzy Jozwiak, Mikk Jürisson, Ali Kabir, Md Awal Kabir, Zubair Kabir, Vidya Kadashetti, Rizwan Kalani, Sanjay Kalra, Vineet Kumar Kamal, Arun Kamireddy, Haidong Kan, Mona Kanaan, Himal Kandel, Kehinde Kazeem Kanmodi, Rami S Kantar, Neeti Kapoor, Paschalis Karakasis, Ibraheem M Karaye, André Karch, Hanie Karimi, Salah Eddin Karimi, Yeganeh Karimi, Arman Karimi Behnagh, Prabin Karki, Hengameh Kasraei, Joonas H Kauppila, Harkiran Kaur, Neda Kaydi, Gbenga A Kayode, Foad Kazemi, Sina Kazemian, Emmanuelle Kesse-Guyot, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Inn Kynn Khaing, Himanshu Khajuria, Amirmohammad Khalaji, Nauman Khalid, Anees Ahmed Khalil, Asaduzzaman Khan, Fayaz Khan, M Nuruzzaman Khan, Maseer Khan, Mohammad Jobair Khan, Moien AB Khan, Yusra H Khan, Shaghayegh Khanmohammadi, Khaled Khatab, Haitham Khatatbeh, Moawiah Mohammad Khatatbeh, Sorour Khateri, Mahalaqua Nazli Khatib, Maryam Khayamzadeh, Hamid Reza Khayat Kashani, Feriha Fatima Khidri, Manoj Khokhar, Atulya Aman Khosla, Majid Khosravi, Jagdish Khubchandani, Saeid Kian, Kwanghyun Kim, Min Seo Kim, Yun Jin Kim, Ruth W Kimokoti, Adnan Kisa, Sezer Kisa, Ali-Asghar Kolahi, Kamrun Nahar Koly, Farzad Kompani, Shivakumar KM Marulasiddaiah Kondlahalli, Miikka Korja, Vladimir Andreevich Korshunov, Oleksii Korzh, Soewarta Kosen, Karel Kostev, Nikhil Kothari, Ashwin Laxmikant Kotnis, Sindhura Lakshmi Koulmane Laxminarayana, Kewal Krishan, Varun Krishna, Vijay Krishnamoorthy, Bindu Krishnan, Jera Kruja, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Md Abdul Kuddus, Mohammed Kuddus, Nuworza Kugbey, Mukhtar Kulimbet, Vishnutheertha Kulkarni, Akshay Kumar, Ashish Kumar, Dewesh Kumar, G Anil Kumar, Nithin Kumar, Rakesh Kumar, Senthil Kumaran D, Amartya Kundu, Satyajit Kundu, Setor K Kunutsor, Om P Kurmi, Dian Kusuma, L V Simhachalam Kutikuppala, Ambily Kuttikkattu, Ville Kytö, Carlo La Vecchia, Ben Lacey, Chandrakant Lahariya, Dharmesh Kumar Lal, Tea Lallukka, Judit Lám, Iván Landires, Anders O Larsson, Savita Lasrado, Kaveh Latifinaibin, Paolo Lauriola, Pablo M Lavados, Basira Kankia Lawal, Long Khanh Dao Le, Nhi Huu Hanh Le, Thao Thi Thu Le, Trang Diep Thanh Le, Paul H Lee, Seung Won Lee, Wei-Chen Lee, Yo Han Lee, Ming-Chieh Li, Wei Li, Xiaopan Li, Yichong Li, Lee-Ling Lim, Stephen S Lim, John C Lin, Daniel Lindholm, Shai Linn, Gang Liu, Runben Liu, Shuke Liu, Xiaofeng Liu, Xuefeng Liu, Erand Llanaj, Chun-Han Lo, Warren David Lo, Valerie Lohner, José Francisco López-Gil, László Lorenzovici, Stefan Lorkowski, Paulo A Lotufo, Giancarlo Lucchetti, Lisha Luo, Jay B Lusk, Zheng Feei Ma, Monika Machoy, Farzan Madadizadeh, Ralph Maddison, Elham Mahmoudi, Golnaz Mahmoudvand, Omar M Makram, Elaheh Malakan Rad, Kashish Malhotra, Ahmad Azam Malik, Iram Malik, Tauqeer Hussain Mallhi, Deborah Carvalho Malta, Abdullah A Mamun, Yosef Manla, Mohammad Hadi Mansouri, Pejman Mansouri, Vahid Mansouri, Mohammad Ali Mansournia, Lorenzo Giovanni Mantovani, Emmanuel Manu, Hamid Reza Marateb, Abdoljalal Marjani, Daniela Martini, Santi Martini, Miquel Martorell, Sharmeen Maryam, Roy Rillera Marzo, Awoke Masrie, Yasith Mathangasinghe, Pallab K Maulik, Mahsa Mayeli, Mohsen Mazidi, Martin McKee, Steven M McPhail, Enkeleint A Mechili, Asim Mehmood, Kamran Mehrabani-Zeinabad, Tesfahun Mekene Meto, Hadush Negash Meles, Walter Mendoza, Ritesh G Menezes, George A Mensah, Sultan Ayoub Meo, Atte Meretoja, Tuomo J Meretoja, Tomislav Mestrovic, Chamila Dinushi Kukulege Mettananda, Tomasz Miazgowski, Irmina Maria Michalek, Ana Carolina Micheletti Gomide Nogueira de Sá, Giuseppe Minervini, Le Huu Nhat Minh, GK Mini, Mojgan Mirghafourvand, Andreea Mirica, Erkin M Mirrakhimov, Mohammad Mirza-Aghazadeh-Attari, Manish Mishra, Sanjeev Misra, Prasanna Mithra, Ahmed Ismail Mohamed, Jama Mohamed, Nouh Saad Mohamed, Ameen Mosa Mohammad, Esmaeil Mohammadi, Saeed Mohammadi, Soheil Mohammadi, Abdollah Mohammadian-Hafshejani, Ibrahim Mohammadzadeh, Hussen Mohammed, Mustapha Mohammed, Salahuddin Mohammed, Shafiu Mohammed, Ali H Mokdad, Hossein Molavi Vardanjani, Mariam Molokhia, Shaher Momani, Lorenzo Monasta, Mohammad Ali Moni, Fateme Montazeri, AmirAli Moodi Ghalibaf, Mahmood Moosazadeh, Maryam Moradi, Yousef Moradi, Paula Moraga, Lidia Morawska, Rafael Silveira Moreira, Shane Douglas Morrison, Reza Mosaddeghi Heris, Elias Mossialos, Parsa Mousavi, Ahmed Msherghi, Sumaira Mubarik, Lorenzo Muccioli, Admir Mulita, Malaisamy Muniyandi, Kavita Munjal, Efren Murillo-Zamora, Sathish Muthu, Woojae Myung, Amin Nabavi, Ashraf Fawzy Nabhan, Ayoub Nafei, Ahamarshan Jayaraman Nagarajan, Pirouz Naghavi, Ganesh R Naik, Gurudatta Naik, Mukhammad David Naimzada, Sanjeev Nair, Tapas Sadasivan Nair, Soroush Najdaghi, Hastyar Hama Rashid Najmuldeen, Noureddin Nakhostin Ansari, Vinay Nangia, Sreenivas Narasimha Swamy, Shumaila Nargus, Delaram Narimani Davani, Bruno Ramos Nascimento, Gustavo G Nascimento, Ali Nasrollahizadeh, Amir Nasrollahizadeh, Zuhair S Natto, Javaid Nauman, Samidi Nirasha Kumari Navaratna, Biswa Prakash Nayak, Vinod C Nayak, Athare Nazri-Panjaki, Rawlance Ndejjo, Ionut Negoi, Ruxandra Irina Negoi, Seyed Aria Nejadghaderi, Chakib Nejjari, Mohammad Hadi Nematollahi, Samata Nepal, Charles Richard James Newton, Dang H Nguyen, Duc Hoang Nguyen, Hau Thi Hien Nguyen, Hien Quang Nguyen, Nhien Ngoc Y Nguyen, Phat Tuan Nguyen, Van Thanh Nguyen, Robina Khan Niazi, Yeshambel T Nigatu, Nasrin Nikravangolsefid, Dina Nur Anggraini Ningrum, Chukwudi A Nnaji, Lawrence Achilles Nnyanzi, Shuhei Nomura, Syed Toukir Ahmed Noor, Bo Norrving, Nawsherwan Nawsherwan, Jean Jacques Noubiap, Chisom Adaobi Nri-Ezedi, George Ntaios, Mpiko Ntsekhe, Fred Nugen, Mario Cesare Nurchis, Dieta Nurrika, Chimezie Igwegbe Nzoputam, Ogochukwu Janet Nzoputam, Bogdan Oancea, Kehinde O Obamiro, Ismail A Odetokun, Martin James O'Donnell, James Odhiambo Oguta, In-Hwan Oh, Tolulope R Ojo-Akosile, Hassan Okati-Aliabad, Sylvester Reuben Okeke, Akinkunmi Paul Okekunle, Lawrence Okidi, Osaretin Christabel Okonji, Morteza Oladnabi, Andrew T Olagunju, Muideen Tunbosun Olaiya, Oladotun Victor Olalusi, Tosin Abiola Olasehinde, Omotola O Olasupo, Matthew Idowu Olatubi, Arão Belitardo Oliveira, Gláucia Maria Moraes Oliveira, Abdulhakeem Abayomi Olorukooba, Isaac Iyinoluwa Olufadewa, Yinka Doris Doris Oluwafemi, Gideon Olamilekan Oluwatunase, Hany A Omar, Ahmed Omar Bali, Adrienne E O'Neil, Sok King Ong, Obinna E Onwujekwe, Abdulahi Opejin Opejin, Michal Ordak, Raffaele Ornello, Doris V Ortega-Altamirano, Alberto Ortiz, Esteban Ortiz-Prado, Wael M S Osman, Uchechukwu Levi Osuagwu, Stanislav S Otstavnov, Mayowa O Owolabi, Ifeoluwa Temitayo Oyeyemi, Ahmad Ozair, Mahesh Padukudru P A, Kevin Pacheco-Barrios, Alicia Padron-Monedero, Jagadish Rao Padubidri, Tamás Palicz, Raul Felipe Palma-Alvarez, Feng Pan, Songhomitra Panda-Jonas, Deepshikha Pande Katare, Anamika Pandey, Ashok Pandey, Seithikurippu R Pandi-Perumal, Leonidas D Panos, Ioannis Pantazopoulos, Paraskevi Papadopoulou, Shahina Pardhan, Pragyan Paramita Parija, Romil R Parikh, Nicholas Parsons, Roberto Passera, Dimitrios Patoulias, Uttam Paudel, Shrikant Pawar, Amy E Peden, Paolo Pedersini, Prince Peprah, Maria Odete Pereira, Mario F P Peres, Arokiasamy Perianayagam, Norberto Perico, Simone Perna, Richard G Pestell, Ionela-Roxana Petcu, Fanny Emily Petermann-Rocha, Hoang Nhat Pham, Hoang Tran Pham, Michael R Phillips, Thomas Pilgrim, Michael A Piradov, Saeed Pirouzpanah, Evgenii Plotnikov, Dimitri Poddighe, Ramesh Poluru, Djordje S Popovic, Maarten J Postma, Akram Pourshams, Naeimeh Pourtaheri, Jalandhar Pradhan, Pranil Man Singh Pradhan, V Prakash, Manya Prasad, Elton Junio Sady Prates, Dimas Ria Angga Pribadi, Jagadeesh Puvvula, Ibrahim Qattea, Gangzhen Qian, Yanan Qiao, Alberto Raggi, Pankaja Raghav Raghav, Pracheth Raghuveer, Fakher Rahim, Md Jillur Rahim, Mahban Rahimifard, Vafa Rahimi-Movaghar, Md Mosfequr Rahman, Mohammad Hifz Ur Rahman, Mosiur Rahman, Muhammad Aziz Rahman, Amir Masoud Rahmani, Mohammad Rahmanian, Nazanin Rahmanian, Vahid Rahmanian, Rahem Rahmati, Setyaningrum Rahmawaty, Gerard Marshall Raj, Sathish Rajaa, Vinoth Rajendran, Pushp Lata Rajpoot, Prashant Rajput, Pradhum Ram, Mahmoud Mohammed Ramadan, Majed Ramadan, Venkitachalam Ramanarayanan, Shakthi Kumaran Ramasamy, Sheena Ramazanu, Juwel Rana, Kritika Rana, Rishabh Kumar Rana, Chhabi Lal Ranabhat, Nemanja Rancic, Amey Rane, Annemarei Ranta, Mithun Rao, Sowmya J Rao, Sina Rashedi, Mohammad-Mahdi Rashidi, Ashkan Rasouli-Saravani, Devarajan Rathish, Santosh Kumar Rauniyar, Salman Rawaf, Christian Razo, Murali Mohan Rama Krishna Reddy, Elrashdy Moustafa Mohamed Redwan, Inayat Ur Rehman, Giuseppe Remuzzi, Nazila Rezaei, Mohsen Rezaeian, Hossein Rezazadeh, Taeho Gregory Rhee, Mavra A Riaz, Antonio Luiz P Ribeiro, Monica Rodrigues, Thales Philipe R Rodrigues da Silva, Jefferson Antonio Buendia Rodriguez, Leonardo Roever, Debby Syahru Romadlon, Allen Guy Ross, Himanshu Sekhar Rout, Bedanta Roy, Priyanka Roy, Simanta Roy, Guilherme de Andrade Ruela, Michele Russo, Godfrey M Rwegerera, Chandan S N, Aly M A Saad, Korosh Saber, Maha Mohamed Saber-Ayad, Cameron John Sabet, Siamak Sabour, Simona Sacco, Basema Ahmad Saddik, Erfan Sadeghi, Mohammad Reza Saeb, Umar Saeed, Sher Zaman Zaman Safi, Rajesh Sagar, Alireza Saghafi, Dominic Sagoe, Fatemeh Saheb Sharif-Askari, Amirhossein Sahebkar, Pragyan Monalisa Sahoo, Soumya Swaroop Sahoo, Mirza Rizwan Sajid, Afeez Abolarinwa Salami, Luciane B Salaroli, Mohamed A Saleh, Mohammed Z Y Salem, Giovanni A Salum, Sara Samadzadeh, Saad Samargandy, Yoseph Leonardo Samodra, Vijaya Paul Samuel, Abdallah M Samy, Juan Sanabria, Itamar S Santos, Milena M Santric-Milicevic, Made Ary Sarasmita, Aswini Saravanan, Yaser Sarikhani, Gargi Sachin Sarode, Sachin C Sarode, Maheswar Satpathy, Zafer Sattouf, Ganesh Kumar Saya, Md Abu Sayeed, Mehdi Sayyah, Nikolaos Scarmeas, Benedikt Michael Schaarschmidt, Markus P Schlaich, Maria Inês Schmidt, Ione Jayce Ceola Schneider, Art Schuermans, Austin E Schumacher, Aletta Elisabeth Schutte, David C Schwebel, Siddharthan Selvaraj, Parijat Sen, Sabyasachi Senapati, Subramanian Senthilkumaran, Mihretu Tagesse Sergindo, Yashendra Sethi, Allen Seylani, Mahan Shafie, Pritik A Shah, Saeed Shahabi, Ataollah Shahbandi, Samiah Shahid, Hamid R Shahsavari, Moyad Jamal Shahwan, Masood Ali Shaikh, Ali S Shalash, Muhammad Aaqib Shamim, Mehran Shams-Beyranvand, Anas Shamsi, Alfiya Shamsutdinova, Mohd Shanawaz, Mohammed Shannawaz, Medha Sharath, Amin Sharifan, Azam Sharifi, Javad Sharifi-Rad, Anupam Sharma, Manoj Sharma, Sourabh Sharma, Ujjawal Sharma, Vishal Sharma, Rahim Ali Sheikhi, Adithi Shetty, Mahabalesh Shetty, Premalatha K Shetty, Desalegn Shiferaw, Mika Shigematsu, Tariku Shimels, Min-Jeong Shin, Rahman Shiri, Aminu Shittu, Abdul-karim Olayinka Shitu, Ivy Shiue, Seyed Afshin Shorofi, Sunil Shrestha, Kerem Shuval, Yafei Si, Emmanuel Edwar Siddig, Mithun Sikdar, João Pedro Silva, Luís Manuel Lopes Rodrigues Silva, Abhinav Singh, Baljinder Singh, Garima Singh, Harmanjit Singh, Jasvinder A Singh, Kuldeep Singh, Narinder Pal Singh, Paramdeep Singh, Puneetpal Singh, Jussi O T Sipilä, Shravan Sivakumar, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, David A Sleet, Farrukh Sobia, Bogdan Socea, Abdullah Al Mamun Sohag, Ranjan Solanki, Shipra Solanki, Yerukneh Solomon, Yi Song, Soroush Soraneh, Reed J D Sorensen, Houman Sotoudeh, Ireneous N Soyiri, Michael Spartalis, Chandrashekhar T Sreeramareddy, Suresh Kumar Srinivasamurthy, Panagiotis Stachteas, Lauryn K Stafford, Benjamin A Stark, Antonina V Starodubova, Narayan Subedi, Vetriselvan Subramaniyan, Muhammad Suleman, Abida Sultana, Zhong Sun, Johan Sundström, Vinay Suresh, Sri Susanty, Chandan Kumar Swain, Lukasz Szarpak, Sree Sudha T Y, Payam Tabaee Damavandi, Rafael Tabarés-Seisdedos, Seyyed Mohammad Tabatabaei, Shima Tabatabai, Celine Tabche, Mohammad Tabish, Jyothi Tadakamadla, Santosh Kumar Tadakamadla, Amirmasoud Taheri, Jabeen Taiba, Iman M Talaat, Ashis Talukder, Mircea Tampa, Jacques Lukenze Tamuzi, Ker-Kan Tan, Haosu Tang, Manoj Tanwar, Ingan Ukur Tarigan, Elvis Enowbeyang Tarkang, Nathan Y Tat, Seyed Mohammad Tavangar, Arash Tehrani-Banihashemi, Mojtaba Teimoori, Mohamad-Hani Temsah, Reem Mohamad Hani Temsah, Masayuki Teramoto, Wegen Beyene Tesfamariam, Edosa Geta Tesfaye Gta, Ramna Thakur, Pugazhenthan Thangaraju, Rajshree Thapa, Rekha Thapar, Rasiah Thayakaran, Sathish Thirunavukkarasu, Joe Thomas, Nikhil Kenny Kenny Thomas, Amanda G Thrift, Jing Tian, Ales Tichopad, Jansje Henny Vera Ticoalu, Chalachew Tiruneh, Krishna Tiwari, Amir Tiyuri, Marcello Tonelli, Roman Topor-Madry, Marcos Roberto Tovani-Palone, Khaled Trabelsi, Ngoc Ha Tran, Thang Huu Tran, Nguyen Tran Minh Duc, Domenico Trico, Samuel Joseph Tromans, Thien Tan Tri Tai Truyen, Daniel Hsiang-Te Tsai, Aristidis Tsatsakis, Evangelia Eirini Tsermpini, Ermias A A Turuse, Stefanos Tyrovolas, Aniefiok John Udoakang, Arit Udoh, Atta Ullah, Sana Ullah, Muhammad Umair, Muhammad Umar, Brigid Unim, Bhaskaran Unnikrishnan, Daniele Urso, Jibrin Sammani Usman, Marco Vacante, Seyed Mohammad Vahabi, Sanaz Vahdati, Asokan Govindaraj Vaithinathan, Omid Vakili, Rohollah Valizadeh, Jef Van den Eynde, Orsolya Varga, Shoban Babu Varthya, Tommi Juhani Vasankari, Balachandar Vellingiri, Narayanaswamy Venketasubramanian, Madhur Verma, Massimiliano Veroux, Georgios-Ioannis Verras, Dominique Vervoort, Jorge Hugo Villafañe, Simona Villani, Manish Vinayak, Maria Viskadourou, Simona Ruxandra Volovat, Victor Volovici, Hatem A Wafa, Yasir Waheed, Waseem Wahood, Cong Wang, Fang Wang, Shu Wang, Song Wang, Yanzhong Wang, Yuan-Pang Wang, Mary Njeri Wanjau, Muhammad Waqas, Emebet Gashaw Wassie, Gizachew Tadesse Wassie, Zihan Wei, Robert G Weintraub, Haftom Legese Weldetinsaa, Dakshitha Praneeth Wickramasinghe, Nuwan Darshana Wickramasinghe, Tissa Wijeratne, Peter Willeit, Charles D A Wolfe, Yen Jun Wong, Utoomporn Wongsin, Chenkai Wu, Felicia Wu, YaJuan Wu, Zenghong Wu, Hong Xiao, Suowen Xu, Xiaoyue Xu, Kazumasa Yamagishi, Danting Yang, Yuichiro Yano, Amir Yarahmadi, Habib Yaribeygi, Yuichi Yasufuku, Hiroshi Yatsuya, Fereshteh Yazdanpanah, Mohammad Hosein Yazdanpanah, Pengpeng Ye, Renjulal Yesodharan, Saber Yezli, Siyan Yi, Xinglin Yi, Dehui Yin, Dong Keon Yon, Naohiro Yonemoto, Chuanhua Yu, Elaine A Yu, Ke Yun, Hadiza Yusuf, Siddhesh Zadey, Nima Zafari, Burhan Abdullah Zaman, Sojib Bin Zaman, Aurora Zanghì, Iman Zare, Fatemeh Zarimeidani, Armin Zarrintan, Michael Zastrozhin, Dawit Zemedikun, Youjie Zeng, Beijian Zhang, Haijun Zhang, Liqun Zhang, Yunquan Zhang, Zhiqiang Zhang, Hanqing Zhao, Claire Chenwen Zhong, Shang Cheng Zhou, Bin Zhu, Lei Zhu, Abzal Zhumagaliuly, Makan Ziafati, Magdalena Zielińska, Yossef Teshome Zikarg, Ghazal Zoghi, Sa'ed H Zyoud, Samer H Zyoud, Catherine O Johnson, Gregory A Roth, Balakrishnan Sukumaran Nair, Ilari Rautalin, Anjali Bhati, Catherine Bisignano, Theo Vos, Christopher J L Murray

    The Lancet Neurology   Vol. 23 ( 10 ) page: 973 - 1003   2024.10

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    DOI: 10.1016/s1474-4422(24)00369-7

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  2. Association between predicted level of water turnover deficit and all-cause and cause-specific mortalities among Japanese adults: The Japan Collaborative Cohort Study Reviewed International journal

    Daiki Watanabe, Isao Muraki, Hiroshi Yatsuya, Akiko Tamakoshi

    The American Journal of Clinical Nutrition     2024.9

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    DOI: 10.1016/j.ajcnut.2024.09.021

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  3. Nonrestorative Sleep and Type 2 Diabetes Incidence: the Aichi Workers’ Cohort Study Reviewed

    Jingyi Lin, Zean Song, Yuanying Li, Chifa Chiang, Yoshihisa Hirakawa, Yoshihisa Nakano, Young-Jae Hong, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Hiroshi Yatsuya

    Journal of Epidemiology   Vol. 34 ( 9 ) page: 428 - 433   2024.9

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    <p><b>Background:</b> The term “nonrestorative sleep (NRS)” refers to an unrefreshed feeling at wake-up and is a domain of poor sleep quality. Previous research has demonstrated that NRS is linked to a number of diseases and adverse health outcomes, but less is known regarding the link between NRS and diabetes, particularly in Japanese.</p><p><b>Methods:</b> We studied 3,665 middle-aged male participants of the Aichi Workers’ Cohort Study who were followed-up from 2002 through 2019. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) of incident type 2 diabetes mellitus (T2DM) in relation to NRS adjusted for potential confounding variables.</p><p><b>Results:</b> During a median follow-up of 14.6 years, 421 type 2 diabetes cases were identified. Participants with NRS had a higher crude incidence rate of T2DM (11.2/1,000 person-years), compared to participants without NRS (9.3/1,000 person-years). In the fully adjusted model, individuals who reported having NRS had a significantly higher risk of developing T2DM (HR1.36; 95% CI, 1.10–1.67). The association was observed only in participants under 50 years old (HR 1.82; 95% CI, 1.36–2.43), not in the older (50 years or older) participants (<i>P</i> for interaction = 0.025). In contrast, stratified analyses by the presence of shift work, obesity, or sleep duration showed similar associations in all the strata.</p><p><b>Conclusion:</b> NRS was associated with higher risk of T2DM in middle-aged Japanese male workers independent of a variety of lifestyle factors and other sleep problems.</p>

    DOI: 10.2188/jea.JE20230184

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  4. Mortality after partner’s cancer diagnosis or death: A population-based prospective cohort study in Japan Reviewed

    Makiuchi Takeshi, Kakizaki Masako, Sobue Tomotaka, Kitamura Tetsuhisa, Yatsuya Hiroshi, Yamaji Taiki, Iwasaki Motoki, inoue Manami, Tsugane Shoichiro, Sawada Norie

    Journal of Epidemiology   Vol. advpub ( 0 )   2024.8

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    <p><b>Background:</b> The health statuses of closely connected individuals are interdependent. Little is known about mortality risk associated with partner’s cancer diagnosis and cause-specific mortality risk associated with partner’s death.</p><p><b>Methods:</b> Relative risks for all-cause and cause-specific mortality following a partner’s cancer diagnosis or death compared to the period when the partner is cancer-free and alive were investigated in the population-based prospective cohort study that enrolled 140,420 people at the age between 40-69 in 1990-1994.</p><p><b>Results:</b> 55,050 participants (27,665 men and 27,385 women) who were identified as married couples were followed-up for 1,073,746.1 (518,368.5 in men and 555,377.6 in women) person-years, during which 9,816 deaths (7,217 in men and 2,599 in women) were observed. After a partner’s cancer diagnosis, the mortality rate ratio (MRR) of all-cause mortality was not increased among both men and women, while an increase of externally-caused MRR was observed. The suicide MRR significantly increased among men (MRR = 2.90 [95% CI, 1.70–4.93]) and it persisted for more than 5 years. After a partner’s death, the MRRs of all-cause, cardiovascular disease (CVD), respiratory disease (RD), and externally-caused mortality significantly increased only among men. Stratified analysis by smoking status among men showed significantly increased MRRs of CVD and RD mortality among former/current smokers, but not among never-smokers.</p><p><b>Conclusion:</b> Partner’s cancer diagnosis did not increase all-cause mortality risk, but increased externally-caused mortality risk, especially suicide among men. The impact of partner’s death on mortality risk differed by the mortality causes and sex, and smoking affected some of cause-specific mortality risk.</p>

    DOI: 10.2188/jea.JE20240114

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  5. Impact of diabetes on mortality and hospitalization after dementia diagnosis: Health insurance claims data analysis Reviewed

    Masaaki Matsunaga, Shinichi Tanihara, Yupeng He, Hiroshi Yatsuya, Atsuhiko Ota

    Geriatrics &amp; Gerontology International   Vol. 24 ( 8 ) page: 773 - 781   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Aim

    Japan faces a public health challenge of dementia, further complicated by the increasing complications from diabetes within its rapidly aging population. This study assesses the impact of diabetes on mortality and hospitalization among individuals aged ≥75 years with new dementia diagnoses.

    Methods

    We analyzed administrative claims data in Japan from 73 324 individuals aged ≥75 years with dementia, of whom 17% had comorbid diabetes. Dementia and diabetes were identified from the International Classification of Diseases, Tenth Revision codes. We used Kaplan–Meier survival analysis, Cox proportional hazards analysis, and population attributable fractions (PAFs) to evaluate the impact on mortality and hospitalization after dementia diagnosis.

    Results

    One‐year mortality and 1‐year hospitalization probabilities in individuals with dementia and diabetes (10.3% and 31.7%, respectively) were higher than those without diabetes (8.3% and 25.4%, respectively). The adjusted hazard ratios for individuals with diabetes, as compared to those without, were 1.126 (95% confidence interval [CI], 1.040–1.220) for mortality and 1.191 (95% CI, 1.140–1.245) for hospitalization. The PAFs from the comorbidity of dementia and diabetes were 2.2% for mortality and 3.1% for hospitalization. Subgroup analysis showed that the PAFs were highest in men aged 75–79 years and women aged 80–84 years for mortality and in individuals aged 75–79 for hospitalization.

    Conclusion

    During the early postdiagnosis period, comorbid diabetes increases mortality and hospitalization risks in older adults with dementia. The variation in disease burden across age groups underscores the need for age‐specific health care strategies to manage comorbid diabetes in individuals with dementia. Geriatr Gerontol Int 2024; 24: 773–781.

    DOI: 10.1111/ggi.14926

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  6. Efficacy of Immune Checkpoint Inhibitors in Postoperative Recurrence of Wild-type EGFR Non-Small Cell Lung Cancer. Reviewed

    Imamura Y, Kato T, Nomata Y, Okado S, Watanabe H, Kawasumi Y, Nakanishi K, Kadomatsu Y, Ueno H, Nakamura S, Mizuno T, Hase T, Tanaka I, Ishii M, Yatsuya H, Chen-Yoshikawa TF

    Anticancer research   Vol. 44 ( 8 ) page: 3451 - 3461   2024.8

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    Background/Aim: Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of non-small cell lung cancer (NSCLC), but specific outcomes of ICIs treatment among patients with postoperative recurrence of NSCLC remain unclear. The objective of the study was to compare the efficacy of ICIs and chemotherapy with conventional chemotherapy only in patients with postoperative recurrence of epidermal growth factor receptor (EGFR) wild-type NSCLC. Patients and Methods: A retrospective analysis was performed on patients who underwent anatomical lung resection at the Nagoya University Hospital and were treated for postoperative recurrence of wild-type EGFR NSCLC. This study evaluated the prognosis for postoperative recurrence, including ICIs treatment and other clinicopathological factors. Results: Of the 83 patients included in the analysis, 20 patients underwent chemotherapy and 63 patients underwent chemotherapy combined with ICIs. The combination of ICIs and chemotherapy significantly prolonged survival after recurrence (median survival: 33.1 months vs. 22.0 months, p=0.01). In the ICIs group, no significant differences in survival were detected between patients with different programmed death ligand 1 (PD-L1) status (Tumor Proportion Scores: <1%, 1%-49%, ≥50%, p=0.27). Multivariate analysis revealed that postoperative distant recurrence was a significant poor prognostic factor for survival after recurrence (HR=1.85, 95% CI=1.06-3.25, p=0.03), and combining ICIs with chemotherapy significantly improved survival after recurrence (HR=0.43, 95% CI=0.24-0.78, p<0.01). Conclusion: Combination of ICIs with chemotherapy significantly prolonged survival of postoperative recurrence with wild-type EGFR NSCLC regardless of PD-L1 status.

    DOI: 10.21873/anticanres.17165

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  7. Lifetime Risk of Incident Coronary Heart Disease, Stroke, and Cardiovascular Disease: The Japan Public Health Center-Based Prospective Study. Reviewed

    Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Isao Muraki, Hiroyasu Iso, Manami Inoue, Shoichiro Tsugane, Norie Sawada

    Journal of atherosclerosis and thrombosis   Vol. advpub ( 0 )   2024.7

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    AIM: The constellation of cardiovascular disease (CVD) risk factors greatly impacts the lifetime risk (LTR) of incident CVD, but the LTR has not been thoroughly evaluated in the Japanese population. METHODS: We conducted a prospective study involving a total of 25,896 individuals 40-69 years old without a history of CVD in 1995 (Cohort I) and 1993-1994 (Cohort II) in Japan. CVD risk factors (blood pressure, non-high-density lipoprotein [HDL] cholesterol levels, smoking status, and glucose concentrations) were used to stratify them by risk. The sex-specific LTR of incident coronary heart disease, stroke, atherosclerotic CVD, and total CVD were estimated for participants 45 years old in the 4 risk categories with the cumulative incidence rate, adjusting for the competing risk of death. RESULTS: We found apparent differences in the LTR of total CVD according to the risk stratification. Individuals with ≥ 2 of the risk factors of blood pressure ≥ 140/90 mmHg or treated, non-HDL cholesterol level ≥ 170 mg/dL or treated, current smoker, and diabetes had substantially higher adjusted LTRs of CVD than those in other groups, with a LTR of 26.5% (95% confidence interval, 24.0%-29.0%) for men and 15.3% (13.1%-17.5%) for women at 45 years. The LTR of incident stroke was the highest among CVDs, and the presence of hypertension and diabetes mellitus strongly influenced the LTR of total CVD. CONCLUSION: The impact of risk accumulation on LTR of CVD was greater in men, and 1 in 4 men with ≥ 2 major risk factors at 45 years of age developed CVD in their lifetime.

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  8. Association between milk consumption in middle age and frailty in later life: The Aichi Workers' cohort study Reviewed

    Young Jae Hong, Rei Otsuka, Zean Song, Chisato Fukuda, Rina Tajima, Jingyi Lin, Mizuho Hibino, Mei Kobayashi, Yupeng He, Masaaki Matsunaga, Atsuhiko Ota, Yoshihisa Nakano, Yuanying Li, Koji Tamakoshi, Hiroshi Yatsuya

    Geriatrics &amp; Gerontology International   Vol. 24 ( 7 ) page: 700 - 705   2024.7

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    Aim

    Several studies have shown that dairy consumption in old age is effective in preventing frailty. However, there is a lack of evidence regarding the association between milk consumption during middle age and the development of frailty in old age. Therefore, we carried out an investigation to explore the association between milk consumption during middle age and development of frailty examined after over 15 years of follow up in a long‐term cohort study in Japan.

    Methods

    We studied 265 participants aged 60–79 years (212 men and 53 women) in 2018, who participated in both the baseline survey in 2002 and the frailty assessment in 2018. The amount of milk consumption (g/day) at baseline was age‐ and energy‐adjusted, and classified into three categories (no, low and high consumption: 0 g/day, ≤135.86 g/day, &gt;135.86 g/day in men and 0 g/day, ≤126.44 g/day, &gt;126.44 g/day in women). Odds ratios (OR) and 95% confidence intervals (CI) for prefrailty/frailty after adjusting for lifestyles at baseline, stratified by sex, were estimated using logistic regression analysis.

    Results

    The prevalence of prefrailty/frailty in 2018 was 37.7% and 28.3% in men and women, respectively. Milk consumption categories were inversely associated with the prevalence of prefrailty/frailty in men (OR 0.34, 95% CI 0.14–0.84 in low consumption; OR 0.31, 95% CI 0.10–0.95 in high consumption; P &lt; 0.05), but not in women (OR 0.53, 95% CI 0.11–2.65; P = 0.44).

    Conclusions

    In this study, milk intake in middle‐aged men was inversely associated with the prevalence of prefrailty/frailty later in life. Geriatr Gerontol Int 2024; 24: 700–705.

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  9. 定年退職期の就労継続と脳灰白質容積の10年間の変化

    大塚 礼, 西田 裕紀子, 丹下 智香子, 八谷 寛, 久保田 彩, 安藤 富士子, 下方 浩史, 加藤 隆司, 中村 昭範, 荒井 秀典

    日本老年医学会雑誌   Vol. 61 ( Suppl. ) page: 141 - 141   2024.5

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  10. 20歳から老年期にかけての体重変動はフレイル発症関連要因である 愛知職域コホート研究

    洪 英在, 大塚 礼, 宋 澤安, 福田 知里, 小林 芽生, 松永 眞章, 太田 充彦, 李 媛英, 玉腰 浩司, 八谷 寛

    日本老年医学会雑誌   Vol. 61 ( Suppl. ) page: 133 - 133   2024.5

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  11. Relationship between size of pharyngeal and palatine tonsils and apnea–hypopnea index in pediatric obstructive sleep apnea Reviewed

    Kaneko Masamichi, Hirata Masatoshi, Kimura Ayami, Inada Hiroya, Shikano Kazuki, Ito Satoshi, Okano Takayuki, Yatsuya Hiroshi, Nakata Seiichi

    Fujita Medical Journal   Vol. 10 ( 2 ) page: 60 - 63   2024.5

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    <p><b>Objective: </b>To determine whether the combination of the pharyngeal tonsil grade and palatine tonsil grade results in differences in the apnea–hypopnea index (AHI) and to determine whether each parameter separately (pharyngeal tonsil grade and palatine tonsil grade) results in differences in severe obstructive sleep apnea (OSA).</p><p><b>Methods: </b>This cross-sectional study involved 107 children (mean age, 7.2 years; range, 4–12 years) suspected of having OSA because of snoring or sleep-related complaints. The patients underwent polysomnography, and their palatine and pharyngeal tonsils were graded.</p><p><b>Results: </b>In examining whether the palatine tonsils and pharyngeal tonsils could be risk factors for severe OSA, the adjusted odds ratios were 4.42 for palatine tonsil grade 4 versus 1–3 and 10.40 for pharyngeal tonsil grade 4 versus 1–3; both were highly statistically significant. We also found that the AHI when both the pharyngeal and palatine tonsils were grade 4 was higher than the AHI expected for the pharyngeal and palatine tonsils alone.</p><p><b>Conclusions: </b>The combination of grade 4 pharyngeal tonsils and grade 4 palatine tonsils resulted in an AHI much higher than the AHI of other combinations (pharyngeal tonsils grades 1–3 and 4, palatine tonsils grades 1–3 and 4). We believe that grade 4 pharyngeal tonsils and grade 4 palatine tonsils have a great influence on severe OSA and that grade 4 pharyngeal tonsils increase the AHI.</p>

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  12. 日本人中年男性における長期的な収縮期血圧変動とうつ状態発症との関連

    小林 芽生, 李 媛英, 宋 澤安, 洪 英在, 日比野 瑞歩, 田島 里菜, 太田 充彦, 大塚 礼, 玉腰 浩司, 八谷 寛

    日本循環器病予防学会誌   Vol. 59 ( 2 ) page: 127 - 127   2024.4

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  13. Factors influencing interprofessional collaboration in long-term care from a multidisciplinary perspective: a case study approach. Reviewed

    Yoshida Y, Hirakawa Y, Hong YJ, Mamun MR, Shimizu H, Nakano Y, Yatsuya H

    Home health care services quarterly     page: 1 - 20   2024.3

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    Systematic assessments of interprofessional collaboration barriers and enablers in long-term care settings are critical for delivering person-centered healthcare. However, research on factors influencing interprofessional collaboration in long-term care settings is limited. For this study, 65 healthcare professionals across multiple facilities experienced in long-term care in Japan participated in online focus group discussions and individual interviews to discuss cases. The qualitative data were analyzed using qualitative content analysis. Seven themes emerged: coordination, the need for care manager training, hierarchy among healthcare professionals, specialization but not the mind-set of overspecialization, casual conversations, electronic group communication tools, and excessive fear of personal information protection. These findings highlight the need to develop coordinator roles and for interprofessional education on the proper approach to personal information protection laws. Furthermore, daily casual conversations, the use of online platforms, and the prevention of patients being left behind due to overspecialization are required.

    DOI: 10.1080/01621424.2024.2331452

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  14. 新型コロナウイルス流行期の超過死亡と関連要因に関する主張への懸念 Reviewed

    鈴木 貞夫, 尾島 俊之, 永田 知里, 八谷 寛, 若井 建志

    東海公衆衛生雑誌   Vol. 11 ( 2 ) page: 143 - 144   2024.3

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    DOI: 10.24802/tpha.2023-11

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  15. Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers’ cohort study Reviewed International coauthorship

    Abubakr Ahmed Abdullah Al-shoaibi, Yuanying Li, Zean Song, Young Jae Hong, Chifa Chiang, Yoshihisa Nakano, Yoshihisa Hirakawa, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Hiroshi Yatsuya

    Obesity Research &amp; Clinical Practice   Vol. 18 ( 2 ) page: 101 - 108   2024.3

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  16. Prediction model of the risk for lateral local recurrence in locally advanced rectal cancer without enlarged lateral lymph nodes: Lessons from a Japanese multicenter pooled analysis of 812 patients Reviewed

    Ogura, A; Shiomi, A; Yamamoto, S; Komori, K; Hamamoto, H; Manabe, S; Miyakita, H; Okuda, J; Yatsuya, H; Uehara, K

    ANNALS OF GASTROENTEROLOGICAL SURGERY   Vol. 8 ( 2 ) page: 284 - 292   2024.3

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    Aim: Although the oncological impact of lateral lymph node dissection on enlarged lateral lymph nodes has been gradually accepted over the last decade, that on lateral lymph nodes without swelling remains doubtful. This study aimed to develop a prediction model for the future risk of lateral local recurrence and to clarify the value of adding lateral lymph node dissection in locally advanced rectal cancer without enlarged lateral lymph nodes. Methods: This retrospective, multi-institutional study recruited 812 patients with cStage II/III low rectal cancer without enlarged lateral lymph nodes <7 mm. Total lateral local recurrence was a hypothetical value of future risk of lateral local recurrence when lateral lymph node dissection was never performed. Results: Overall, total lateral local recurrences were observed in 67 patients (8.3%). In the multivariate analyses, the strongest risk factor for total local recurrences was no preoperative chemoradiotherapy (odds ratio [OR][95%Cl]: 33.2 [4.56–241.7], P < 0.001), followed by tumor distance ≤40 mm (OR [95%Cl]: 2.71 [1.51–4.86], P < 0.001) and lateral lymph node 5–7 mm (OR[95%Cl]: 2.38 [1.26–4.48], P = 0.007). In patients with lateral lymph nodes of 5–7 mm, the total lateral recurrence rate was 4.8% after preoperative chemoradiotherapy. Lateral lymph node dissection could reduce from a total lateral local recurrence of 21.6% to an actual lateral local recurrence of 8.0% in patients without preoperative treatment. Conclusion: We introduce a novel prediction model of future risk of lateral local recurrences, which has the potential to enable us to indicate lateral lymph node dissection selectively according to the patients' risks.

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  17. Prevalence, severity, and risk factors of cancer-related fatigue among working cancer survivors: a systematic review and meta-analysis Reviewed

    Masaaki Matsunaga, Yupeng He, May Thet Khine, Xuliang Shi, Ryusei Okegawa, Yuanying Li, Hiroshi Yatsuya, Atsuhiko Ota

    Journal of Cancer Survivorship     2024.2

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    DOI: 10.1007/s11764-024-01557-8

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    Other Link: https://link.springer.com/article/10.1007/s11764-024-01557-8/fulltext.html

  18. The effect of age on the relationship between body mass index and risks of incident stroke subtypes: The JPHC study. Reviewed International journal

    Hanson Gabriel Nuamah, Yuanying Li, Hiroshi Yatsuya, Kazumasa Yamagishi, Isao Saito, Yoshihiro Kokubo, Isao Muraki, Hiroyasu Iso, Manami Inoue, Shoichiro Tsugane, Norie Sawada

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   Vol. 33 ( 2 ) page: 107486 - 107486   2024.2

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    OBJECTIVE: The associations between body mass index (BMI) and stroke subtypes, particularly intracerebral hemorrhage, have not been consistent. Such inconsistencies may be due to differences in the age at which BMI was obtained. We examined the possible age modifications in the association between BMI and stroke risk. MATERIALS AND METHODS: We followed 88,754 participants, aged 40-69 years at baseline (1990-1994), of the Japan Public Health Center-based prospective (JPHC) study for stroke incidence. BMI was obtained using self-reported body weight and height, which were categorized using the following cut-off points: 18.5, 21, 23, 25, 27.5, and 30 kg/m2. Time-dependent Cox proportional hazards models that updated BMI and covariates using 5- and 10-year questionnaire responses were used to estimate hazard ratios and 95 % confidence intervals. The analyses were stratified by age group (40-59 and ≥60 years) and the age of the individuals was updated. RESULTS: During the median follow-up period of 19 years, we documented 4,690 strokes, including 2,781 ischemic strokes and 1,358 intracerebral hemorrhages. After adjusting for sex, age, smoking, alcohol consumption, leisure-time physical activity, history of hypertension, dyslipidemia, and diabetes mellitus, we observed a positive linear association between BMI and ischemic stroke (linear trend, p < 0.001) in both age groups (interaction p>0.05). In contrast, a curvilinear association between BMI and intracerebral hemorrhage was observed in both the middle (curvilinear trend, p=0.017) and the older group (curvilinear trend, p=0.098) (interaction p>0.05). CONCLUSION: BMI and stroke associations did not vary significantly with age, although the association may differ according to subtype.

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  19. Anti-Factor Xa Activity in Patients With Chronic Thromboembolic Pulmonary Disease With or Without Pulmonary Hypertension Treated With Factor Xa Inhibitors

    Nakano, Y; Adachi, S; Kondo, H; Hirose, M; Adachi, T; Nishiyama, I; Yasuda, K; Yoshida, M; Yatsuya, H; Murohara, T

    CIRCULATION   Vol. 148   2023.11

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  20. 肥満疫学研究の最前線 高齢期の身体指標の加齢変化と要介護予防

    大塚 礼, 八谷 寛

    肥満研究   Vol. 29 ( 合同学術集会抄録集 ) page: 131 - 131   2023.11

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  21. The electrophysiological index can effectively predict subsequent coronary artery aneurysm in children with Kawasaki disease Reviewed International journal

    Suzuki Daijiro, Suzuki Takanori, Fujino Masayuki, Asai Yumiko, Kojima Arisa, Uchida Hidetoshi, Saito Kazuyoshi, Kusuki Hirofumi, Li Yuanying, Yatsuya Hiroshi, Sadanaga Tsuneaki, Hata Tadayoshi, Yoshikawa Tetsushi

    Fujita Medical Journal   Vol. 9 ( 4 ) page: 275 - 281   2023.11

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    <p><b>Objectives: </b>The Gunma score is used to predict the severity of Kawasaki disease (KD), including coronary artery aneurysm (CAA) as a cardiac complication, in Japan. Additionally, the characteristic ratio of ventricular repolarization (T-peak to T-end interval to QT interval [Tp-e/QT]) on a surface electrocardiogram reflects myocardial inflammation. This study aimed to determine whether the Tp-e/QT can be used to predict CAA in children with KD.</p><p><b>Methods: </b>We analyzed chest surface electrocardiograms of 112 children with KD before receiving intravenous immunoglobulin therapy using available software (QTD; Fukuda Denshi, Tokyo, Japan).</p><p><b>Results: </b>The Tp-e/QT (lead V5) was positively correlated with the Gunma score (r=0.352, p<0.001). The Tp-e/QT was larger in patients with CAA (residual CAA at 1 month after onset) than in those without CAA (0.314±0.026 versus 0.253±0.044, p=0.003). A receiver operating characteristic curve analysis was performed to assess whether the Gunma score and Tp-e/QT could predict subsequent CAA. The area under the curve of the Gunma score was 0.719 with the cutoff set at 5 points. The area under the curve of the Tp-e/QT was 0.892 with a cutoff value of 0.299. The fit of the prediction models to the observed probability was tested by the Hosmer–Lemeshow test with calibration plots using Locally weighted scatterplot smoothing (LOESS) fit. The Gunma score (p=0.95) and Tp-e/QT (p=0.95) showed a good fit.</p><p><b>Conclusions: </b>The Tp-e/QT is a useful biomarker in predicting coronary aneurysm complications in KD.</p>

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  22. Association of psychological factors with advanced-level functional competency: Findings from the Aichi workers’ cohort study, 2002–2019 Reviewed International coauthorship

    KM Saif-Ur-Rahman, Young Jae Hong, Yuanying Li, Masaaki Matsunaga, Zean Song, Masako Shimoda, Abubakr Al-Shoaibi, Yupeng He, Md Razib Mamun, Yukiko Hirano, Chifa Chiang, Yoshihisa Hirakawa, Atsuko Aoyama, Koji Tamakoshi, Atsuhiko Ota, Rei Otsuka, Hiroshi Yatsuya

    Heliyon   Vol. 9 ( 11 ) page: e21931 - e21931   2023.11

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  23. Good death for people living with dementia: a qualitative study Reviewed

    Mamun, MR; Hirakawa, Y; Saif-Ur-Rahman, KM; Hong, YJ; Song, Z; Yoshida, Y; Yatsuya, H

    BMC GERIATRICS   Vol. 23 ( 1 ) page: 665   2023.10

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    Background: Ensuring a good death is one of the primary objectives of palliative care and end-of-life care. There is insufficient evidence regarding what defines a good death for people living with dementia. Obtaining an understanding of what constitutes a good death could help improve dementia care. This study aimed to explore how multiple stakeholders perceive a good death for people living with dementia. Methods: This qualitative study was carried out across six prefectures in Japan. Enrollment of participants took place within dementia outpatient clinics, hospitals, daycare centers, and community centers. A total of thirty-three in-depth interviews with people living with dementia, physicians, and nurses were conducted. Six focus group discussions were performed with family caregivers and care workers. Verbatim transcripts of the interviews were prepared, and inductive content analysis was used to examine the data. Findings: Regarding the perception of a good death, the following themes were derived: (1) painless death; (2) dying in a preferred environment; (3) family’s coping with loss; (4) maintaining regular life; (5) living with respect; and (6) preparation for death. All these themes are interrelated. Participants viewed a good death as a process rather than a single event. Conclusion: This study identifies crucial components of a good death for people living with dementia. The findings could be used to improve dementia care.

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  24. Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis. Reviewed International coauthorship International journal

    Morgan E Grams, Josef Coresh, Kunihiro Matsushita, Shoshana H Ballew, Yingying Sang, Aditya Surapaneni, Natalia Alencar de Pinho, Amanda Anderson, Lawrence J Appel, Johan Ärnlöv, Fereidoun Azizi, Nisha Bansal, Samira Bell, Henk J G Bilo, Nigel J Brunskill, Juan J Carrero, Steve Chadban, John Chalmers, Jing Chen, Elizabeth Ciemins, Massimo Cirillo, Natalie Ebert, Marie Evans, Alejandro Ferreiro, Edouard L Fu, Masafumi Fukagawa, Jamie A Green, Orlando M Gutierrez, William G Herrington, Shih-Jen Hwang, Lesley A Inker, Kunitoshi Iseki, Tazeen Jafar, Simerjot K Jassal, Vivekanand Jha, Aya Kadota, Ronit Katz, Anna Köttgen, Tsuneo Konta, Florian Kronenberg, Brian J Lee, Jennifer Lees, Adeera Levin, Helen C Looker, Rupert Major, Cheli Melzer Cohen, Makiko Mieno, Mariko Miyazaki, Olivier Moranne, Isao Muraki, David Naimark, Dorothea Nitsch, Wonsuk Oh, Michelle Pena, Tanjala S Purnell, Charumathi Sabanayagam, Michihiro Satoh, Simon Sawhney, Elke Schaeffner, Ben Schöttker, Jenny I Shen, Michael G Shlipak, Smeeta Sinha, Benedicte Stengel, Keiichi Sumida, Marcello Tonelli, Jose M Valdivielso, Arjan D van Zuilen, Frank L J Visseren, Angela Yee-Moon Wang, Chi-Pang Wen, David C Wheeler, Hiroshi Yatsuya, Kunihiro Yamagata, Jae Won Yang, Ann Young, Haitao Zhang, Luxia Zhang, Andrew S Levey, Ron T Gansevoort

    JAMA   Vol. 330 ( 13 ) page: 1266 - 1277   2023.10

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    IMPORTANCE: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. OBJECTIVE: To evaluate associations of lower eGFR based on creatinine alone, lower eGFR based on creatinine combined with cystatin C, and more severe albuminuria with adverse kidney outcomes, cardiovascular outcomes, and other health outcomes. DESIGN, SETTING, AND PARTICIPANTS: Individual-participant data meta-analysis of 27 503 140 individuals from 114 global cohorts (eGFR based on creatinine alone) and 720 736 individuals from 20 cohorts (eGFR based on creatinine and cystatin C) and 9 067 753 individuals from 114 cohorts (albuminuria) from 1980 to 2021. EXPOSURES: The Chronic Kidney Disease Epidemiology Collaboration 2021 equations for eGFR based on creatinine alone and eGFR based on creatinine and cystatin C; and albuminuria estimated as urine albumin to creatinine ratio (UACR). MAIN OUTCOMES AND MEASURES: The risk of kidney failure requiring replacement therapy, all-cause mortality, cardiovascular mortality, acute kidney injury, any hospitalization, coronary heart disease, stroke, heart failure, atrial fibrillation, and peripheral artery disease. The analyses were performed within each cohort and summarized with random-effects meta-analyses. RESULTS: Within the population using eGFR based on creatinine alone (mean age, 54 years [SD, 17 years]; 51% were women; mean follow-up time, 4.8 years [SD, 3.3 years]), the mean eGFR was 90 mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR was 11 mg/g (IQR, 8-16 mg/g). Within the population using eGFR based on creatinine and cystatin C (mean age, 59 years [SD, 12 years]; 53% were women; mean follow-up time, 10.8 years [SD, 4.1 years]), the mean eGFR was 88 mL/min/1.73 m2 (SD, 22 mL/min/1.73 m2) and the median UACR was 9 mg/g (IQR, 6-18 mg/g). Lower eGFR (whether based on creatinine alone or based on creatinine and cystatin C) and higher UACR were each significantly associated with higher risk for each of the 10 adverse outcomes, including those in the mildest categories of chronic kidney disease. For example, among people with a UACR less than 10 mg/g, an eGFR of 45 to 59 mL/min/1.73 m2 based on creatinine alone was associated with significantly higher hospitalization rates compared with an eGFR of 90 to 104 mL/min/1.73 m2 (adjusted hazard ratio, 1.3 [95% CI, 1.2-1.3]; 161 vs 79 events per 1000 person-years; excess absolute risk, 22 events per 1000 person-years [95% CI, 19-25 events per 1000 person-years]). CONCLUSIONS AND RELEVANCE: In this retrospective analysis of 114 cohorts, lower eGFR based on creatinine alone, lower eGFR based on creatinine and cystatin C, and more severe UACR were each associated with increased rates of 10 adverse outcomes, including adverse kidney outcomes, cardiovascular diseases, and hospitalizations.

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  25. 孤食は、世帯構成や孤独感とは独立した抑うつ関連因子である 愛知職域コホート研究

    洪 英在, 大塚 礼, 平川 仁尚, 太田 充彦, 玉腰 浩司, 八谷 寛

    日本公衆衛生学会総会抄録集   Vol. 82回   page: 286 - 286   2023.10

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  26. Applicability of a web-based 24-hour dietary recall tool for Japanese populations in large-scale epidemiological studies. Reviewed

    Yoshie Hose, Junko Ishihara, Ayaka Kotemori, Misako Nakadate, Sachiko Maruya, Junta Tanaka, Hiroshi Yatsuya, Atsuko Aoyama, Chifa Chiang, Tsuneo Konta, Takamasa Kayama, Yoshiyuki Ueno, Manami Inoue, Norie Sawada, Shoichiro Tsugane, Ribeka Takachi

    Journal of epidemiology   Vol. 33 ( 8 ) page: 419 - 427   2023.8

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    BACKGROUND: Recent innovations in information and communication technology have made it possible to assess diet using web-based methods; however, their applicability in the general population remains unclear. Hence, we aimed to examine the applicability of a web-based 24-hour dietary recall (24HR) tool to large-scale epidemiological studies by determining the sampling rate and characteristics of randomly selected participants (partially entire population) from a Japanese cohort study. METHODS: In total, 5,013 individuals were recruited from a cohort of 21,537 individuals, and 975 agreed to participate in this study. The participants selected either self-administered web-based dietary 24HR (self-administered 24HR) or interviewer-administered telephone-based 24HR (interviewer-administered 24HR) as the method for the dietary assessment and answered questions regarding the acceptability of the system. RESULTS: The response rate of the 975 participants was 19.4%, and approximately 4.5% of the total study population. About half of them chose the self-administered 24HR (46.9%). The median time required for the self-administered and interviewer-administered 24HR was 25 and 27 minutes, respectively. In the self-administered 24HR, older people, regardless of sex, tended to require a longer time, and approximately 60% of the participants rated the ease of use of the system as "somewhat difficult" or "difficult." CONCLUSIONS: Characteristics of the participants in this study were not systemically different from those of the entire study population. Improvements in approach for the entering cooking details and the dish name selection may be necessary for better acceptability in order to be accepted as a self-administered 24HR.

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  27. Impact of Cardiovascular Disease on the Death Certificate Diagnosis of Heart Failure, Ischemic Heart Disease, and Cerebrovascular Disease - The Japan Public Health Center-Based Prospective Study. Reviewed

    Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 87 ( 9 ) page: 1196 - +   2023.8

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    BACKGROUND: There is considerable interest in the trending discrepancy between ischemic heart disease (IHD) and heart failure (HF) in vital statistics. Clinically, acute myocardial infarction (AMI) and stroke are closely associated with HF, but their contribution to HF as the underlying cause of death (UCD) is unclear.Methods and Results: In 1990 and 1992-1993, we enrolled a total of 140,420 residents of Japanese nationality (aged 40-69 years) from 11 public health center areas. We prospectively examined the occurrence of cardiovascular disease (CVD), including AMI, sudden cardiac death within 1 h (SCD), and stroke, and analyzed the 14,375 participants without a history of CVD at baseline who died during the 20-year follow-up. A time-dependent Cox proportional hazards model was used to estimate hazard ratios and the population attributable fraction (PAF) of AMI, AMI+SCD, stroke, and CVD for deaths due to HF, IHD, and cerebrovascular disease as the UCD, adjusted for individuals' lifestyles and comorbid conditions. The PAF of AMI for HF deaths was 2.4% (95% confidence interval [CI] 1.7-2.9%), which increased to 12.0% (95% CI 11.6-12.2%) for AMI+SCD. The PAF of CVD-attributed HF deaths was estimated to be 17.6% (95% CI 15.9-18.9%). CONCLUSIONS: HF as the UCD was partly explained by CVD. The data imply that most HF deaths reported in vital statistics may be associated with underlying causes other than CVD.

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  28. Associations between changes in social contact pattern and the mental health status of Chinese adults: cross-sectional findings Reviewed International coauthorship

    Zhang, JY; Zhou, S; Wang, Q; Hou, FF; Han, X; Shen, GD; Chiang, CF; Yatsuya, H; Zhang, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 3 ) page: 476 - 489   2023.8

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    The study aims to examine the associations between social contact pattern changes and mental health status, including depression, anxiety, and loneliness, among Chinese adults in the context of coronavirus disease 2019 (COVID-19). Data on social contact patterns before and after the outbreak of COVID-19 were obtained from 3511 participants. Mental health (ie, depression, anxiety, and loneliness) was assessed by the 9-item Patient Health Questionnaire, Dark Future Scale, and the 9-scale Three-Item Loneliness Scale, respectively. Poisson regression analyses revealed that the participants who had increased in-person communication were more likely to have mental disorders [depression: prevalence ratio (PR)=1.13, 95% confidence interval (CI): 1.02, 1.26; anxiety: PR=1.15, 95% CI: 1.01, 1.30]. The current study concluded that the in-person communication increase before and after the outbreak of COVID-19 was associated with mental disorders among Chinese adults.

    DOI: 10.18999/nagjms.85.3.476

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  29. Risk and population attributable fraction of stroke subtypes in Japan. Reviewed

    Hiroshi Yatsuya, Kazumasa Yamagishi, Yuanying Li, Isao Saito, Yoshihiro Kokubo, Isao Muraki, Manami Inoue, Shoichiro Tsugane, Hiroyasu Iso, Norie Sawada

    Journal of epidemiology   Vol. 34 ( 5 ) page: 211 - 217   2023.7

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    BACKGROUND: Associations of major risk factors for stroke with total and each type of stroke as well as subtypes of ischemic stroke and their population attributable fractions had not been examined comprehensively. METHODS: Participants of the Japan Public Health Center-based prospective (JPHC) Study Cohort II without histories of cardiovascular disease and cancer (n=14,797) were followed from 1993 through 2012. Associations of current smoking, hypertension, diabetes, overweight (body mass index ≥ 25 kg/m2), non-high-density lipoprotein cholesterol (non-HDLC) categories, low HDLC (< 40 mg/dL), urine protein, and history of arrhythmia were examined in a mutually-adjusted Cox regression model that included age and sex. Population attributable fraction (PAF) was estimated using the hazard ratios and the prevalence of risk factors among cases. RESULTS: Subjects with hypertension were 1.63 to 1.84 times more likely to develop any type of stroke. Diabetes, low HDLC, current smoking, overweight, urine protein, and arrhythmia were associated with risk of overall and ischemic stroke. Hypertension and urine protein were associated with risk of intracerebral hemorrhage while current smoking, hypertension, and low non-HDLC were associated with subarachnoid hemorrhage. Hypertension alone accounted for more than a quarter of stroke incidence, followed by current smoking and diabetes. High non-HDLC, current smoking, low HDLC, and overweight contributed mostly to large-artery occlusive stroke. Arrhythmia explained 13.2% of embolic stroke. Combined PAFs of all the modifiable risk factors for total, ischemic and large-artery occlusive strokes were 36.7 and 44.5% and 61.5%, respectively. CONCLUSION: Although there are differences according to the subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.

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  30. Work and Family Conflicts, Depression, and "Ikigai": A Mediation Analysis in a Cross-Cultural Study Between Japanese and Egyptian Civil Workers. Reviewed International coauthorship

    Ehab S Eshak, Sachiko Baba, Hiroshi Yatsuya, Hiroyasu Iso, Yoshihisa Hirakawa, Eman M Mahfouz, Chiang Chifa, Ryoto Sakaniwa, Ayman S El-Khateeb

    Journal of epidemiology   Vol. 33 ( 7 ) page: 360 - 366   2023.7

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    BACKGROUND: Work-family conflicts (total-WFCs) could associate with mental health, and having ikigai (a purpose of life) may mediate this association. METHODS: In a cross-cultural study of 4792 Japanese Aichi Workers' Cohort study participants and 3109 Egyptian civil workers, the Midlife Development in the United States (MIDUS) questionnaire measured total-WFCs and Center for Epidemiological Studies Depression (CES-D) 11-item scale measured depression. Logistic regression models estimated odds ratios (ORs) of having depression and a high-ikigai across levels of total-WFCs (low, moderate, and high), and the PROCESS macro of Hayes tested the mediation effect. RESULTS: The prevalence of high total-WFCs, depression, and having a high-ikigai were 17.9%, 39.4%, and 70.1% in Japanese women, 10.5%, 26.8%, and 70.1% in Japanese men, 23.7%, 58.2%, and 24.7% in Egyptian women, and 19.1%, 38.9%, and 36.9% in Egyptian men. Compared with participants with low total-WFCs, the multivariable ORs (95% CIs) of depression in Japanese women and men with high total-WFCs were 4.11 (2.99-5.65) and 5.42 (4.18-7.02), and those in Egyptian women and men were 4.43 (3.30-5.95) and 4.79 (3.53-6.48). The respective ORs of having a high-ikigai were 0.46 (0.33-0.64) and 0.40 (0.31-0.52) in Japanese women and men and were 0.34 (0.24-0.48) and 0.28 (0.20-0.39) in Egyptian women and men. No interaction between total-WFCs and country was observed for the associations with depression or ikigai. Ikigai has mediated (up to 18%) the associations between the total-WFCs and depression, especially in Egyptian civil workers. CONCLUSIONS: Total-WFCs were associated with depression, and having low-ikigai mediated these associations in Japanese and Egyptian civil workers.

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  31. Impact of combined resection of the internal iliac artery on loss of volume of the gluteus muscles after pelvic exenteration Reviewed

    Murata, Y; Uehara, K; Ogura, A; Ishigaki, S; Aiba, T; Mizuno, T; Kokuryo, T; Yokoyama, Y; Yatsuya, H; Ebata, T

    SURGERY TODAY   Vol. 53 ( 7 ) page: 791 - 799   2023.7

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    Purpose: To clarify the influence of additional internal iliac artery (IIA) resection on the loss of the gluteus muscle volume after pelvic exenteration (PE). Methods: The subjects of this retrospective analysis were 78 patients who underwent PE with or without IIA resection (n = 44 and n = 34, respectively) between 2006 and 2018. The areas of gluteal muscles (GMs) and psoas muscles (PSMs) were calculated using CT images before and 6 months after PE, and the difference was compared. Results: The volumes of the GMs and PSMs were significantly reduced after PE (P < 0.001 and P = 0.005, respectively). In the IIA resection group, the GMs were significantly reduced after surgery, but the PSMs were not. The maximum GM (Gmax) was the most atrophied among the GMs. Multivariable analysis revealed that complete IIA resection was an independent promotor of the loss of volume of the Gmax (P = 0.044). In 18 patients with unilateral IIA resection, the downsizing rate of the Gmax was significantly greater on the resected side than on the non-resected side (P = 0.008). Conclusions: The GMs and PSMs were significantly smaller after PE. Complete IIA resection reduced the Gmax area remarkably. Preservation of the superior gluteus artery is likely to help maintain Gmax size, suggesting a potential preventative measure against secondary sarcopenia.

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  32. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 Reviewed International coauthorship

    Kanyin Liane Ong, Lauryn K Stafford, Susan A McLaughlin, Edward J Boyko, Stein Emil Vollset, Amanda E Smith, Bronte E Dalton, Joe Duprey, Jessica A Cruz, Hailey Hagins, Paulina A Lindstedt, Amirali Aali, Yohannes Habtegiorgis Abate, Melsew Dagne Abate, Mohammadreza Abbasian, Zeinab Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Samar Abd ElHafeez, Rami Abd-Rabu, Deldar Morad Abdulah, Abu Yousuf Md Abdullah, Vida Abedi, Hassan Abidi, Richard Gyan Aboagye, Hassan Abolhassani, Eman Abu-Gharbieh, Ahmed Abu-Zaid, Tigist Demssew Adane, Denberu Eshetie Adane, Isaac Yeboah Addo, Oyelola A Adegboye, Victor Adekanmbi, Abiola Victor Adepoju, Qorinah Estiningtyas Sakilah Adnani, Rotimi Felix Afolabi, Gina Agarwal, Zahra Babaei Aghdam, Marcela Agudelo-Botero, Constanza Elizabeth Aguilera Arriagada, Williams Agyemang-Duah, Bright Opoku Ahinkorah, Danish Ahmad, Rizwan Ahmad, Sajjad Ahmad, Aqeel Ahmad, Ali Ahmadi, Keivan Ahmadi, Ayman Ahmed, Ali Ahmed, Luai A Ahmed, Syed Anees Ahmed, Marjan Ajami, Rufus Olusola Akinyemi, Hanadi Al Hamad, Syed Mahfuz Al Hasan, Tareq Mohammed Ali AL-Ahdal, Tariq A Alalwan, Ziyad Al-Aly, Mohammad T AlBataineh, Jacqueline Elizabeth Alcalde-Rabanal, Sharifullah Alemi, Hassam Ali, Tahereh Alinia, Syed Mohamed Aljunid, Sami Almustanyir, Rajaa M Al-Raddadi, Nelson Alvis-Guzman, Firehiwot Amare, Edward Kwabena Ameyaw, Sohrab Amiri, Ganiyu Adeniyi Amusa, Catalina Liliana Andrei, Ranjit Mohan Anjana, Adnan Ansar, Golnoosh Ansari, Alireza Ansari-Moghaddam, Anayochukwu Edward Anyasodor, Jalal Arabloo, Aleksandr Y Aravkin, Demelash Areda, Hidayat Arifin, Mesay Arkew, Benedetta Armocida, Johan Ärnlöv, Anton A Artamonov, Judie Arulappan, Raphael Taiwo Aruleba, Ashokan Arumugam, Zahra Aryan, Mulu Tiruneh Asemu, Mohammad Asghari-Jafarabadi, Elaheh Askari, Daniel Asmelash, Thomas Astell-Burt, Mohammad Athar, Seyyed Shamsadin Athari, Maha Moh'd Wahbi Atout, Leticia Avila-Burgos, Ahmed Awaisu, Sina Azadnajafabad, Darshan B B, Hassan Babamohamadi, Muhammad Badar, Alaa Badawi, Ashish D Badiye, Nayereh Baghcheghi, Nasser Bagheri, Sara Bagherieh, Sulaiman Bah, Saeed Bahadory, Ruhai Bai, Atif Amin Baig, Ovidiu Constantin Baltatu, Hamid Reza Baradaran, Martina Barchitta, Mainak Bardhan, Noel C Barengo, Till Winfried Bärnighausen, Mark Thomaz Ugliara Barone, Francesco Barone-Adesi, Amadou Barrow, Hamideh Bashiri, Afisu Basiru, Sanjay Basu, Saurav Basu, Abdul-Monim Mohammad Batiha, Kavita Batra, Mulat Tirfie Bayih, Nebiyou Simegnew Bayileyegn, Amir Hossein Behnoush, Alehegn Bekele Bekele, Melaku Ashagrie Belete, Uzma Iqbal Belgaumi, Luis Belo, Derrick A Bennett, Isabela M Bensenor, Kidanemaryam Berhe, Alemshet Yirga Berhie, Sonu Bhaskar, Ajay Nagesh Bhat, Jasvinder Singh Bhatti, Boris Bikbov, Faiq Bilal, Bagas Suryo Bintoro, Saeid Bitaraf, Veera R Bitra, Vesna Bjegovic-Mikanovic, Virginia Bodolica, Archith Boloor, Michael Brauer, Javier Brazo-Sayavera, Hermann Brenner, Zahid A Butt, Daniela Calina, Luciana Aparecida Campos, Ismael R Campos-Nonato, Yin Cao, Chao Cao, Josip Car, Márcia Carvalho, Carlos A Castañeda-Orjuela, Ferrán Catalá-López, Ester Cerin, Joshua Chadwick, Eeshwar K Chandrasekar, Gashaw Sisay Chanie, Jaykaran Charan, Vijay Kumar Chattu, Kirti Chauhan, Huzaifa Ahmad Cheema, Endeshaw Chekol Abebe, Simiao Chen, Nicolas Cherbuin, Fatemeh Chichagi, Saravana Babu Chidambaram, William C S Cho, Sonali Gajanan Choudhari, Rajiv Chowdhury, Enayet Karim Chowdhury, Dinh-Toi Chu, Isaac Sunday Chukwu, Sheng-Chia Chung, Kaleb Coberly, Alyssa Columbus, Daniela Contreras, Ewerton Cousin, Michael H Criqui, Natália Cruz-Martins, Sarah Cuschieri, Bashir Dabo, Omid Dadras, Xiaochen Dai, Albertino Antonio Moura Damasceno, Rakhi Dandona, Lalit Dandona, Saswati Das, Ana Maria Dascalu, Nihar Ranjan Dash, Mohsen Dashti, Claudio Alberto Dávila-Cervantes, Vanessa De la Cruz-Góngora, Gebiso Roba Debele, Kourosh Delpasand, Fitsum Wolde Demisse, Getu Debalkie Demissie, Xinlei Deng, Edgar Denova-Gutiérrez, Salil V Deo, Emina Dervišević, Hardik Dineshbhai Desai, Aragaw Tesfaw Desale, Anteneh Mengist Dessie, Fikreab Desta, Syed Masudur Rahman Dewan, Sourav Dey, Kuldeep Dhama, Meghnath Dhimal, Nancy Diao, Daniel Diaz, Monica Dinu, Mengistie Diress, Shirin Djalalinia, Linh Phuong Doan, Deepa Dongarwar, Francisco Winter dos Santos Figueiredo, Bruce B Duncan, Siddhartha Dutta, Arkadiusz Marian Dziedzic, Hisham Atan Edinur, Michael Ekholuenetale, Temitope Cyrus Ekundayo, Islam Y Elgendy, Muhammed Elhadi, Waseem El-Huneidi, Omar Abdelsadek Abdou Elmeligy, Mohamed A Elmonem, Destaw Endeshaw, Hawi Leul Esayas, Habitu Birhan Eshetu, Farshid Etaee, Ibtihal Fadhil, Adeniyi Francis Fagbamigbe, Ayesha Fahim, Shahab Falahi, MoezAlIslam Ezzat Mahmoud Faris, Hossein Farrokhpour, Farshad Farzadfar, Ali Fatehizadeh, Ghazal Fazli, Xiaoqi Feng, Tomas Y Ferede, Florian Fischer, David Flood, Ali Forouhari, Roham Foroumadi, Masoumeh Foroutan Koudehi, Abhay Motiramji Gaidhane, Santosh Gaihre, Abduzhappar Gaipov, Yaseen Galali, Balasankar Ganesan, MA Garcia-Gordillo, Rupesh K Gautam, Mesfin Gebrehiwot, Kahsu Gebrekirstos Gebrekidan, Teferi Gebru Gebremeskel, Lemma Getacher, Fataneh Ghadirian, Seyyed-Hadi Ghamari, Mohammad Ghasemi Nour, Fariba Ghassemi, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Sameer Vali Gopalani, Habtamu Alganeh Guadie, Shi-Yang Guan, Temesgen Worku Gudayu, Rafael Alves Guimarães, Rashid Abdi Guled, Rajeev Gupta, Kartik Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Bishal Gyawali, Rasool Haddadi, Najah R Hadi, Teklehaimanot Gereziher Haile, Ramtin Hajibeygi, Arvin Haj-Mirzaian, Rabih Halwani, Samer Hamidi, Graeme J Hankey, Md Abdul Hannan, Shafiul Haque, Hamid Harandi, Netanja I Harlianto, S M Mahmudul Hasan, Syed Shahzad Hasan, Hamidreza Hasani, Soheil Hassanipour, Mohammed Bheser Hassen, Johannes Haubold, Khezar Hayat, Golnaz Heidari, Mohammad Heidari, Kamran Hessami, Yuta Hiraike, Ramesh Holla, Sahadat Hossain, Md Shakhaoat Hossain, Mohammad-Salar Hosseini, Mehdi Hosseinzadeh, Hassan Hosseinzadeh, Junjie Huang, Md Nazmul Huda, Salman Hussain, Hong-Han Huynh, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Nayu Ikeda, Irena M Ilic, Milena D Ilic, Leeberk Raja Inbaraj, Afrin Iqbal, Sheikh Mohammed Shariful Islam, Rakibul M Islam, Nahlah Elkudssiah Ismail, Hiroyasu Iso, Gaetano Isola, Ramaiah Itumalla, Masao Iwagami, Chidozie C D Iwu, Ihoghosa Osamuyi Iyamu, Assefa N Iyasu, Louis Jacob, Abdollah Jafarzadeh, Haitham Jahrami, Rajesh Jain, Chinwe Jaja, Zahra Jamalpoor, Elham Jamshidi, Balamurugan Janakiraman, Krishnamurthy Jayanna, Sathish Kumar Jayapal, Shubha Jayaram, Ranil Jayawardena, Rime Jebai, Wonjeong Jeong, Yinzi Jin, Mohammad Jokar, Jost B Jonas, Nitin Joseph, Abel Joseph, Charity Ehimwenma Joshua, Farahnaz Joukar, Jacek Jerzy Jozwiak, Billingsley Kaambwa, Ali Kabir, Robel Hussen Kabthymer, Vidya Kadashetti, Farima Kahe, Rohollah Kalhor, Himal Kandel, Shama D Karanth, Ibraheem M Karaye, Samad Karkhah, Patrick DMC Katoto, Navjot Kaur, Sina Kazemian, Sewnet Adem Kebede, Yousef Saleh Khader, Himanshu Khajuria, Amirmohammad Khalaji, Moien AB Khan, Maseer Khan, Ajmal Khan, Saval Khanal, Moawiah Mohammad Khatatbeh, Amir M Khater, Sorour Khateri, Fatemeh khorashadizadeh, Jagdish Khubchandani, Biruk Getahun Kibret, Min Seo Kim, Ruth W Kimokoti, Adnan Kisa, Mika Kivimäki, Ali-Asghar Kolahi, Somayeh Komaki, Farzad Kompani, Hamid Reza Koohestani, Oleksii Korzh, Karel Kostev, Nikhil Kothari, Ai Koyanagi, Kewal Krishan, Yuvaraj Krishnamoorthy, Barthelemy Kuate Defo, Mohammed Kuddus, Md Abdul Kuddus, Rakesh Kumar, Harish Kumar, Satyajit Kundu, Maria Dyah Kurniasari, Ambily Kuttikkattu, Carlo La Vecchia, Tea Lallukka, Bagher Larijani, Anders O Larsson, Kamaluddin Latief, Basira Kankia Lawal, Thao Thi Thu Le, Trang Thi Bich Le, Shaun Wen Huey Lee, Munjae Lee, Wei-Chen Lee, Paul H Lee, Sang-woong Lee, Seung Won Lee, Samson Mideksa Legesse, Jacopo Lenzi, Yongze Li, Ming-Chieh Li, Stephen S Lim, Lee-Ling Lim, Xuefeng Liu, Chaojie Liu, Chun-Han Lo, Graciliana Lopes, Stefan Lorkowski, Rafael Lozano, Giancarlo Lucchetti, Azzam A Maghazachi, Phetole Walter Mahasha, Soleiman Mahjoub, Mansour Adam Mahmoud, Razzagh Mahmoudi, Marzieh Mahmoudimanesh, Anh Tuan Mai, Azeem Majeed, Pantea Majma Sanaye, Konstantinos Christos Makris, Kashish Malhotra, Ahmad Azam Malik, Iram Malik, Tauqeer Hussain Mallhi, Deborah Carvalho Malta, Abdullah A Mamun, Borhan Mansouri, Hamid Reza Marateb, Parham Mardi, Santi Martini, Miquel Martorell, Roy Rillera Marzo, Reza Masoudi, Sahar Masoudi, Elezebeth Mathews, Andrea Maugeri, Giampiero Mazzaglia, Teferi Mekonnen, Mahboobeh Meshkat, Tomislav Mestrovic, Junmei Miao Jonasson, Tomasz Miazgowski, Irmina Maria Michalek, Le Huu Nhat Minh, GK Mini, J Jaime Miranda, Reza Mirfakhraie, Erkin M Mirrakhimov, Mohammad Mirza-Aghazadeh-Attari, Awoke Misganaw, Kebede Haile Misgina, Manish Mishra, Babak Moazen, Nouh Saad Mohamed, Esmaeil Mohammadi, Mohsen Mohammadi, Abdollah Mohammadian-Hafshejani, Marita Mohammadshahi, Alireza Mohseni, Hoda Mojiri-forushani, Ali H Mokdad, Sara Momtazmanesh, Lorenzo Monasta, Md Moniruzzaman, Ute Mons, Fateme Montazeri, AmirAli Moodi Ghalibaf, Yousef Moradi, Maryam Moradi, Mostafa Moradi Sarabi, Negar Morovatdar, Shane Douglas Morrison, Jakub Morze, Elias Mossialos, Ebrahim Mostafavi, Ulrich Otto Mueller, Francesk Mulita, Admir Mulita, Efrén Murillo-Zamora, Kamarul Imran Musa, Julius C Mwita, Shankar Prasad Nagaraju, Mohsen Naghavi, Firzan Nainu, Tapas Sadasivan Nair, Hastyar Hama Rashid Najmuldeen, Vinay Nangia, Shumaila Nargus, Abdallah Y Naser, Hasan Nassereldine, Zuhair S Natto, Javaid Nauman, Biswa Prakash Nayak, Rawlance Ndejjo, Hadush Negash, Ruxandra Irina Negoi, Hau Thi Hien Nguyen, Dang H Nguyen, Phat Tuan Nguyen, Van Thanh Nguyen, Hien Quang Nguyen, Robina Khan Niazi, Yeshambel T Nigatu, Dina Nur Anggraini Ningrum, Muhammad A Nizam, Lawrence Achilles Nnyanzi, Mamoona Noreen, Jean Jacques Noubiap, Ogochukwu Janet Nzoputam, Chimezie Igwegbe Nzoputam, Bogdan Oancea, Nkechi Martina Odogwu, Oluwakemi Ololade Odukoya, Vivek Anand Ojha, Hassan Okati-Aliabad, Akinkunmi Paul Okekunle, Osaretin Christabel Okonji, Patrick Godwin Okwute, Isaac Iyinoluwa Olufadewa, Obinna E Onwujekwe, Michal Ordak, Alberto Ortiz, Uchechukwu Levi Osuagwu, Abderrahim Oulhaj, Mayowa O Owolabi, Alicia Padron-Monedero, Jagadish Rao Padubidri, Raffaele Palladino, Demosthenes Panagiotakos, Songhomitra Panda-Jonas, Ashok Pandey, Anamika Pandey, Seithikurippu R Pandi-Perumal, Anca Mihaela Pantea Stoian, Shahina Pardhan, Tarang Parekh, Utsav Parekh, Maja Pasovic, Jay Patel, Jenil R Patel, Uttam Paudel, Veincent Christian Filipino Pepito, Marcos Pereira, Norberto Perico, Simone Perna, Ionela-Roxana Petcu, Fanny Emily Petermann-Rocha, Vivek Podder, Maarten J Postma, Ghazaleh Pourali, Naeimeh Pourtaheri, Elton Junio Sady Prates, Mirza Muhammad Fahd Qadir, Ibrahim Qattea, Pourya Raee, Ibrar Rafique, Mehran Rahimi, Mahban Rahimifard, Vafa Rahimi-Movaghar, Md Obaidur Rahman, Muhammad Aziz Rahman, Mohammad Hifz Ur Rahman, Mosiur Rahman, Md Mosfequr Rahman, Mohamed Rahmani, Shayan Rahmani, Vahid Rahmanian, Setyaningrum Rahmawaty, Niloufar Rahnavard, Bibek Rajbhandari, Pradhum Ram, Sheena Ramazanu, Juwel Rana, Nemanja Rancic, Muhammad Modassar Ali Nawaz Ranjha, Chythra R Rao, Deepthi Rapaka, Drona Prakash Rasali, Sina Rashedi, Vahid Rashedi, Ahmed Mustafa Rashid, Mohammad-Mahdi Rashidi, Zubair Ahmed Ratan, Salman Rawaf, Lal Rawal, Elrashdy Moustafa Mohamed Redwan, Giuseppe Remuzzi, Kannan RR Rengasamy, Andre M N Renzaho, Luis Felipe Reyes, Nima Rezaei, Nazila Rezaei, Mohsen Rezaeian, Hossein Rezazadeh, Seyed Mohammad Riahi, Yohanes Andy Rias, Muhammad Riaz, Daniela Ribeiro, Mónica Rodrigues, Jefferson Antonio Buendia Rodriguez, Leonardo Roever, Peter Rohloff, Gholamreza Roshandel, Abazar Roustazadeh, Godfrey M Rwegerera, Aly M A Saad, Maha Mohamed Saber-Ayad, Siamak Sabour, Leila Sabzmakan, Basema Saddik, Erfan Sadeghi, Umar Saeed, Sahar Saeedi Moghaddam, Sare Safi, Sher Zaman Safi, Amene Saghazadeh, Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Amirhossein Sahebkar, Soumya Swaroop Sahoo, Harihar Sahoo, KM Saif-Ur-Rahman, Mirza Rizwan Sajid, Sarvenaz Salahi, Saina Salahi, Mohamed A Saleh, Mohammad Amin Salehi, Joshua A Salomon, Juan Sanabria, Rama Krishna Sanjeev, Francesco Sanmarchi, Milena M Santric-Milicevic, Made Ary Sarasmita, Saman Sargazi, Brijesh Sathian, Thirunavukkarasu Sathish, Monika Sawhney, Markus P Schlaich, Maria Inês Schmidt, Art Schuermans, Abdul-Aziz Seidu, Nachimuthu Senthil Kumar, Sadaf G Sepanlou, Yashendra Sethi, Allen Seylani, Maryam Shabany, Tahereh Shafaghat, Melika Shafeghat, Mahan Shafie, Nilay S Shah, Samiah Shahid, Masood Ali Shaikh, Mohd Shanawaz, Mohammed Shannawaz, Sadaf Sharfaei, Bereket Beyene Shashamo, Rahman Shiri, Aminu Shittu, K M Shivakumar, Siddharudha Shivalli, Parnian Shobeiri, Fereshteh Shokri, Kerem Shuval, Migbar Mekonnen Sibhat, Luís Manuel Lopes Rodrigues Silva, Colin R Simpson, Jasvinder A Singh, Paramdeep Singh, Surjit Singh, Md Shahjahan Siraj, Anna Aleksandrovna Skryabina, Abdullah Al Mamun Sohag, Hamidreza Soleimani, Solikhah Solikhah, Mohammad Sadegh Soltani-Zangbar, Ranjani Somayaji, Reed J D Sorensen, Antonina V Starodubova, Sujata Sujata, Muhammad Suleman, Jing Sun, Johan Sundström, Rafael Tabarés-Seisdedos, Seyyed Mohammad Tabatabaei, Seyed-Amir Tabatabaeizadeh, Mohammad Tabish, Majid Taheri, Ensiyeh Taheri, Elahe Taki, Jacques JL Lukenze Tamuzi, Ker-Kan Tan, Nathan Y Tat, Birhan Tsegaw Taye, Worku Animaw Temesgen, Mohamad-Hani Temsah, Riki Tesler, Pugazhenthan Thangaraju, Kavumpurathu Raman Thankappan, Rajshree Thapa, Samar Tharwat, Nihal Thomas, Jansje Henny Vera Ticoalu, Amir Tiyuri, Marcello Tonelli, Marcos Roberto Tovani-Palone, Domenico Trico, Indang Trihandini, Jaya Prasad Tripathy, Samuel Joseph Tromans, Guesh Mebrahtom Tsegay, Abdul Rohim Tualeka, Derara Girma Tufa, Stefanos Tyrovolas, Sana Ullah, Era Upadhyay, Seyed Mohammad Vahabi, Asokan Govindaraj Vaithinathan, Rohollah Valizadeh, Kim Robin van Daalen, Priya Vart, Shoban Babu Varthya, Tommi Juhani Vasankari, Siavash Vaziri, Madhur verma Verma, Georgios-Ioannis Verras, Danh Cao Vo, Birhanu Wagaye, Yasir Waheed, Ziyue Wang, Yanqing Wang, Cong Wang, Fang Wang, Gizachew Tadesse Wassie, Melissa Y Wei Wei, Abrha Hailay Weldemariam, Ronny Westerman, Nuwan Darshana Wickramasinghe, YiFan Wu, Ratna DWI Wulandari, Juan Xia, Hong Xiao, Suowen Xu, Xiaoyue Xu, Dereje Y Yada, Lin Yang, Hiroshi Yatsuya, Metin Yesiltepe, Siyan Yi, Hunachew Kibret Yohannis, Naohiro Yonemoto, Yuyi You, Sojib Bin Zaman, Nelson Zamora, Iman Zare, Kourosh Zarea, Armin Zarrintan, Mikhail Sergeevich Zastrozhin, Naod Gebrekrstos Zeru, Zhi-Jiang Zhang, Chenwen Zhong, Jingjing Zhou, Magdalena Zielińska, Yossef Teshome Zikarg, Sanjay Zodpey, Mohammad Zoladl, Zhiyong Zou, Alimuddin Zumla, Yves Miel H Zuniga, Dianna J Magliano, Christopher J L Murray, Simon I Hay, Theo Vos

    The Lancet   Vol. 402 ( 10397 ) page: 203 - 234   2023.6

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  33. Predictive Value of Long-Term Systolic Blood Pressure Variability for the Development of Type 2 Diabetes Mellitus Reviewed

    Yatsuya, H; Song, ZA; Hong, YJ; Mamun, R; Yoshida, Y; Akter, T; Nuamah, G; Tajima, R; Lin, JY; Al-Shoaibi, A; Chiang, C; Nakano, Y; Li, YY; Matsunaga, M; Ota, A; Tamakoshi, K

    CIRCULATION   Vol. 147   2023.2

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  34. Relationship between fasting blood glucose levels in middle age and cognitive function in later life: The Aichi Workers’ Cohort Study Reviewed

    Masako Shimoda, Kayo Kaneko, Takeshi Nakagawa, Naoko Kawano, Rei Otsuka, Atsuhiko Ota, Hisao Naito, Masaaki Matsunaga, Naohiro Ichino, Hiroya Yamada, Chifa Chiang, Yoshihisa Hirakawa, Koji Tamakoshi, Atsuko Aoyama, Hiroshi Yatsuya

    Journal of Epidemiology   Vol. 33 ( 2 ) page: 76 - 81   2023.2

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    <p><b>Background:</b> There is limited evidence regarding the relationship between Diabetes mellitus (DM) in middle age and mild cognitive impairment after a follow-up. Therefore, we investigated the relationship between fasting blood glucose (FBG) levels in middle age and cognitive function assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA-J) in later life, following over 15 years of follow-up in the Aichi Workers’ Cohort Study in Japan.</p><p><b>Methods:</b> Participants were 253 former local government employees aged 60–79 years in 2018 who participated in a baseline survey conducted in 2002. Using baseline FBG levels and self-reported history, participants were classified into the normal, impaired fasting glucose (IFG) and, and DM groups. Total MoCA-J score ranges from 0 to 30, and cognitive impairment was defined as MoCA-J score ≤25 in this study. A general linear model was used to estimate the mean MoCA-J scores in the FBG groups, adjusted for age, sex, educational year, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, total cholesterol, and estimated glomerular filtration rate.</p><p><b>Results:</b> The mean MoCA-J score in the total population was 25.0, and the prevalence of MoCA-J score ≤25 was 49.0%. Multivariable-adjusted total MoCA-J scores were 25.2, 24.8, and 23.4 in the normal, IFG, and DM groups, respectively. The odds ratio of MoCA-J score ≤25 in the DM group was 3.29.</p><p><b>Conclusion:</b> FBG level in middle age was negatively associated with total MoCA-J scores assessed later in life, independent of confounding variables.</p>

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  35. Corrigendum to "Secondhand smoke and the risk of incident cardiovascular disease among never-smoking women" [Preventive Medicine 162 (2022) 107145]. Reviewed International journal

    Yuka Kobayashi, Kazumasa Yamagishi, Isao Muraki, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada

    Preventive medicine   Vol. 167   page: 107396 - 107396   2023.2

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  36. The Association between Adult Height and Stroke Incidence in Japanese Men and Women: A Population- Based Case- Control Study Reviewed

    Yoshinobu Kondo, Hiroshi Yatsuya, Atsuhiko Ota, Shoji Matsumoto, Akihiro Ueda, Hirohisa Watanabe, Hideaki Toyoshima

    Journal of Epidemiology   Vol. 33 ( 1 ) page: 23 - 30   2023.1

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    BACKGROUND: No studies have examined the associations between adult height and ischemic stroke subtypes. METHODS: We conducted a population-based case-control study that included 2,451 thrombotic and 687 embolic stroke cases, as well as 1,623 intracerebral and 768 subarachnoid hemorrhage cases without history of stroke aged 40-79 years, and the same number of sex- and age-matched controls. Cases and controls were grouped according to the quintile cut-off values of height in controls, and the third quintile, which was approximately the average height group, was used as the reference group. Height was also examined as a continuous variable as divided by one standard deviation of height in controls. The analyses were carried out separately for participants aged 40-59 years and 60-79 years. RESULTS: In both younger and older men, continuous height was linearly inversely associated with total and thrombotic strokes, and the shortest quintile compared to the reference was associated with increased risks of these strokes. Although height was linearly inversely associated with embolic stroke and intracerebral hemorrhage in younger men, the shortest quintile did not show increased risks of these strokes. Height did not seem to be associated with total stroke and any stroke subtypes in younger women. In contrast, the tallest quintile was significantly associated with increased risks of total stroke and intracerebral hemorrhage, and height tended to be positively associated with these strokes in older women. CONCLUSIONS: We reported the associations between adult height and ischemic stroke subtypes for the first time, which differed according to sex and age-group.

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  37. Including Measures of Chronic Kidney Disease to Improve Cardiovascular Risk Prediction by SCORE2 and SCORE2-OP. Reviewed International coauthorship International journal

    Kunihiro Matsushita, Stephen Kaptoge, Steven Hj Hageman, Yingying Sang, Shoshana H Ballew, Morgan E Grams, Aditya Surapaneni, Luanluan Sun, Johan Arnlov, Milica Bozic, Hermann Brenner, Nigel J Brunskill, Alex R Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai Uwe Eckardt, Ron T Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih Jen Hwang, Tazeen H Jafar, Simerjot K Jassal, Takamasa Kayama, Csaba P Kovesdy, Gijs W Landman, Andrew S Levey, Donald M Lloyd-Jones, Rupert W Major, Katsuyuki Miura, Paul Muntner, Girish N Nadkarni, Christoph Nowak, Takayoshi Ohkubo, Michelle J Pena, Kevan R Polkinghorne, Toshimi Sairenchi, Elke Schaeffner, Markus P Schneider, Varda Shalev, Michael G Shlipak, Marit D Solbu, Nikita Stempniewicz, James Tollitt, José M Valdivielso, Joep van der Leeuw, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Jannick An Dorresteijn, Emanuele Di Angelantonio, Frank Lj Visseren, Lisa Pennells, Josef Coresh

    European journal of preventive cardiology   Vol. 30 ( 1 ) page: 8 - 16   2023.1

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    AIMS: The 2021 ESC guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age and does not include estimated glomerular filtration rate (eGFR) and albuminuria in its algorithms, SCORE2 and SCORE2-OP, to predict CVD risk. We developed and validated an "Add-on" to incorporate CKD measures into these algorithms, using a validated approach. METHODS: In 3,054,840 participants from 34 datasets, we developed three Add-ons (eGFR only, eGFR + urinary albumin-to-creatinine ratio [ACR] [the primary Add-on], and eGFR + dipstick proteinuria) for SCORE2 and SCORE2-OP. We validated c-statistics and net reclassification improvement (NRI), accounting for competing risk of non-CVD death, in 5,997,719 participants from 34 different datasets. RESULTS: In the target population of SCORE2 and SCORE2-OP without diabetes, the CKD Add-on (eGFR only) and CKD Add-on (eGFR + ACR) improved c-statistic by 0.006 (95%CI 0.004-0.008) and 0.016 (0.010-0.023), respectively, for SCORE2 and 0.012 (0.009-0.015) and 0.024 (0.014-0.035), respectively, for SCORE2-OP. Similar results were seen when we included individuals with diabetes and tested the CKD Add-on (eGFR + dipstick). In 57,485 European participants with CKD, SCORE2 or SCORE2-OP with a CKD Add-on showed a significant NRI (e.g., 0.100 [0.062-0.138] for SCORE2) compared to the qualitative approach in the ESC guideline. CONCLUSION: Our Add-ons with CKD measures improved CVD risk prediction beyond SCORE2 and SCORE2-OP. This approach will help clinicians and patients with CKD refine risk prediction and further personalize preventive therapies for CVD.

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  38. MEASURES OF LONG-TERM SYSTOLIC BLOOD PRESSURE VARIABILITY AND THEIR ASSOCIATIONS WITH THE RISK OF INCIDENT TYPE 2 DIABETES MELLITUS

    Song, ZA; He, YP; Chiang, CF; Alshoaibi, AAA; Rahman, KMSU; Mamun, MR; Aoyama, A; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Li, YY; Yatsuya, H

    JOURNAL OF HYPERTENSION   Vol. 41   page: E134 - E134   2023.1

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  39. Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting. Reviewed International coauthorship

    Abubakr Ahmed Abdullah Al-Shoaibi, Yuanying Li, Zean Song, Chifa Chiang, Yoshihisa Hirakawa, K M Saif-Ur-Rahman, Masako Shimoda, Yoshihisa Nakano, Masaaki Matsunaga, Atsuko Aoyama, Koji Tamakoshi, Atsuhiko Ota, Hiroshi Yatsuya

    Journal of atherosclerosis and thrombosis   Vol. 30 ( 5 ) page: 455 - 466   2023

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    AIMS: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers' Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. METHODS: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. RESULTS: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160- mg/dL compared to LDL-C 100-119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91-10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44-2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). CONCLUSION: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

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  40. Sociodemographic and behavioral factors related to obesity among adults in the Republic of Palau based on the WHO STEPwise approach to NCD risk factor surveillance 2011-2013: A cross-sectional study. Reviewed International coauthorship

    Miyuki Hasegawa, Kaori Honjo, Chifa Chiang, Takashi Mita, Berry Moon Watson, Edolem Ikerdeu, Sherilynn Madraisau, Hiroshi Yatsuya, Atsuko Aoyama, Hiroyasu Iso

    Environmental health and preventive medicine   Vol. 28 ( 0 ) page: 39 - 39   2023

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    BACKGROUND: Pacific islanders face drastic increase of obesity-related noncommunicable disease (NCD) due to lifestyle shifts of unhealthy diets and physical inactivity. To date, however, obesity related factors have not been well elucidated in Republic of Palau. This study aimed to investigate sociodemographic and behavioral factors related to obesity using the national level data in Palau. METHODS: This is a cross-sectional, population-based study analyzing random sampling data of 2133 adults aged 25-64 years (of 20 thousand national population) from the WHO STEPwise approach to NCD risk factor surveillance (STEPS) implemented between 2011 and 2013. Sociodemographic and behavioral factors were obtained by the STEPS standardized questionnaire for NCD risk factors plus the question on betel nut chewing because of its common behavior in Micronesian countries. Logistic regression analysis was performed to estimate multivariable odds ratio (OR) of general obesity (body mass index ≥30.0 kg/m2) and central obesity (waist circumference ≥90 cm in men and ≥80 cm in women). RESULTS: Means of body mass index, prevalence of general obesity and central obesity were higher in women (29.9 kg/m2, 45.5% and 85.4%) than in men (29.3 kg/m2, 40.4% and 67.6%). After adjusted by other potential factors, native Palauan (OR 4.4, 95% CI, 2.7-7.0 for men and 3.6, 2.3-5.6 for women), betel nut chewing (1.5, 1.1-2.1 for men and 1.6, 1.2-2.3 for women), men who work at government office (1.6, 1.2-2.1), women with higher household income (1.4, 1.0-1.8) were positively associated with general obesity, while frequent vegetable intake were inversely associated with it among women (0.71, 0.54-0.93). Similar associations were observed between the aforementioned factors and central obesity. CONCLUSIONS: Native Palauan, people with betel nut chewing behavior, government employment and higher income appeared to be associated with obesity, while frequent vegetable consumption were inversely associated with obesity. Further interventions for prevention and control of obesity are necessary through the enhancing public relation activities to understand harmful health effects on betel nuts chewing and recommending domestic production of vegetables.

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  41. Renal Dysfunction after Rectal Cancer Surgery: A Long-term Observational Study Reviewed

    Sando Masanori, Uehara Kay, Li Yuanying, Ogura Atsushi, Murata Yuki, Mizuno Takashi, Yatsuya Hiroshi, Ebata Tomoki

    Journal of the Anus, Rectum and Colon   Vol. 7 ( 3 ) page: 176 - 185   2023

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    <p><b>Objectives: </b>Despite the high incidence of urinary dysfunction (UD) after rectal surgery, it remains questionable whether UD causes future chronic kidney disease (CKD). This study aimed to clarify the long-term trends in renal function and risk factors for future CKD after rectal resection.</p><p><b>Methods: </b>For comparison, patients who underwent rectal resection (n = 129) and colectomy (n = 127) between 2006 and 2017 were identified. The estimated glomerular filtration rate (eGFR) ratio was calculated as the ratio to the baseline. "eGFR ratio < 0.75 at 3-year" was adopted as a surrogate indicator of future CKD.</p><p><b>Results: </b>eGFR ratio significantly decreased in the rectal cohort compared with the colon cohort at 1.5 years (0.9 vs. 0.95, <i>p</i> = 0.008) and at 3 years (0.85 vs. 0.94, <i>p</i> < 0.001). Although the preoperative prevalence of CKD was lower in the rectal than the colon cohort (13.9% vs. 23.6%, <i>p</i> = 0.055), it was similar at 3 years (29.5% vs. 30.7%). In multivariate analysis, females, and cT4 were independent risk factors for future CKD, but UD itself was not.</p><p><b>Conclusions: </b>Postoperative eGFR significantly decreased after rectal cancer surgery compared to colectomy. The prevalence of CKD more than doubled at 3 years after rectal resection. The female sex and cT4 tumor, instead of the UD, were independent risk factors for future CKD.</p>

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  42. Increasing Role of Overweight/Obesity as the Determinant of Hypertension and the Consequent Cardiovascular Diseases in Japan

    Yatsuya Hiroshi

    Journal of Atherosclerosis and Thrombosis   Vol. 30 ( 4 ) page: 323 - 325   2023

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  43. Psychological Distress During the Coronavirus Disease 2019 Pandemic and Associated Factors Among Undergraduate Students in Japan Reviewed

    Sato, Y; Yatsuya, H; Saijo, Y; Yoshioka, E; Tabuchi, T

    DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS   Vol. 17 ( 12 ) page: e294   2022.12

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    Objective: This cross-sectional study aimed to examine factors potentially associated with psychological distress among undergraduate students during the coronavirus disease 2019 pandemic in Japan. Methods: We analyzed data of 958 undergraduates (median age 20 y; 56.8% women) from a Web-based, self-administered questionnaire survey conducted from August to September 2020. Prevalence ratios (PRs) for psychological distress defined as 5 points or over of the Kessler Psychological Distress Scale (K6) were calculated by Poisson regression models. Results: The proportion of psychological distress was 40.0%. In the mutually-adjusted model, the following were significantly associated with psychological distress: decreases in household income to 50-99% of the prepandemic amount compared with no change (PR = 1.48), newly experiencing unpaid wages compared with no experience (PR = 1.44), insufficient money to buy necessities compared with no shortage (PR = 1.45), receiving a student loan or scholarship compared with none (PR = 1.27), and communication 1 to 3 times a month compared with at least once a week (PR = 1.22). In contrast, school closure during the pandemic compared with no closure was inversely associated with psychological distress (PR = 0.78). Conclusions: Among undergraduate students in Japan, economic difficulties significantly predicted psychological distress.

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  44. Possible contribution of COVID-19 vaccination to the subsequent mental well-being in Japan. Reviewed International journal

    Chifa Chiang, Shuhei Morita, Yoshihisa Hirakawa, Farzana Tanzin Priya, Yuka Matsumoto, Atsuhiko Ota, Hiroshi Yatsuya, Takahiro Tabuchi

    Scientific reports   Vol. 12 ( 1 ) page: 21195 - 21195   2022.12

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    The coronavirus disease 2019 (COVID-19) pandemic has had a severe impact on mental well-being. Vaccination may have played a pivotal role in enduring this mental health crisis. The present study aimed to longitudinally investigate the association between COVID-19 vaccination and mental health status among Japanese population in 2021. Longitudinal data of 17,089 individuals aged 15-79 years who participated in a nationwide online study were analyzed. Baseline and follow-up mental health statuses were assessed using the Kessler Psychological Distress Scale (K6). General linear and multivariable logistic regression models adjusted for baseline levels of mental distress were used to examine the association between vaccine receipt and follow-up levels of mental health. Mean K6 scores were lower in the vaccinated than in the non-vaccinated participants. Those who had received one or two doses of COVID-19 vaccines were associated with improved mental health at follow-up in subjects with psychological distress at baseline (odds ratio [OR] 1.31 and 1.35, respectively) and were inversely associated with deteriorated mental health status at follow-up in subjects without psychological distress at baseline (OR 0.66 and 0.70, respectively) compared with no vaccination groups, respectively. The present study would indicate that one or two doses of COVID-19 vaccinations contributed to mental well-being in Japan. This finding might provide evidence for promoting vaccination against COVID-19 and emerging infectious diseases in the future.

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  45. Super-additive associations between parity and education level on mortality from cardiovascular disease and other causes: the Japan Collaborative Cohort Study Reviewed International journal

    Yasukawa S., Eguchi E., Tamakoshi A., Iso H., Tamakoshi A., Mori M., Kaneko Y., Tsuji I., Nakamura Y., Yamagishi K., Mikami H., Kurosawa M., Hoshiyama Y., Tanabe N., Tamakoshi K., Wakai K., Ando M., Suzuki K., Hashimoto S., Yatsuya H., Kikuchi S., Wada Y., Okabayashi S., Ozasa K., Mikami K., Sakata K., Kurozawa Y., Fujino Y.

    BMC Women's Health   Vol. 22 ( 1 )   2022.12

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    Background: While women’s parity status and education level have independent associations with cardiovascular and other diseases, no studies have evaluated the additive interaction of these two factors. Therefore, we examined the additive interaction between parity and education level on mortality from stroke, coronary heart disease, total cardiovascular disease, cancer, non-cardiovascular disease, and non-cancer causes, and all causes in Japanese women. Methods: This study followed 41,242 women aged 40–79 years without a history of cardiovascular disease or cancer from 1988 to 1990 until 2009. Baseline parity and education level were classified into four categories, with highly educated parous women as the reference group. Cox proportional hazards regression analyses were performed to calculate the risk of mortality. We also assessed the additive interactions between parity and education level on mortality from cardiovascular disease and other causes using the relative excess risk due to interaction obtained using Cox models. Results: During the median follow-up period of 19.1 years, we identified 6299 deaths. In a multivariable model adjusted for cardiovascular disease and other disease risk factors, nulliparous women with low education levels had increased multivariable-adjusted hazard ratios of 1.67 (95% confidence interval [CI] 1.13, 2.47) for stroke, 1.98 (95% CI 1.15, 3.39) for coronary heart disease, 1.71 (95% CI 1.34,2.18) for total cardiovascular disease, 1.69 (95% CI 1.33, 2.14) for non-cardiovascular and non-cancer, and 1.51 (95% CI 1.30, 1.75) for all-cause mortality when compared with highly educated parous women. Moreover, we observed significant additive interactions between parity and education level on total cardiovascular disease mortality (P = 0.04), non-cardiovascular disease and non-cancer mortality (P = 0.01), and all-cause mortality (P = 0.005). Conclusions: Nulliparity and low education levels are super-additively associated with total cardiovascular disease, non-cardiovascular and non-cancer, and all-cause mortality risks, suggesting that nulliparous women with low education levels need specific support for preventing mortality related to cardiovascular and other diseases.

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  46. The association of public trust with the utilization of digital contact tracing for COVID-19 in Japan. Reviewed International journal

    Yupeng He, Hiroshi Yatsuya, Atsuhiko Ota, Takahiro Tabuchi

    Public health in practice (Oxford, England)   Vol. 4   page: 100279 - 100279   2022.12

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    Objectives: To examin whether public trust was associated with the utilization of COVID-19 Contact Confirming Application (COCOA) in those who self-reported a history of COVID-19. Study design: Cross-sectional study. Methods: Data were obtained from the Japan Society and New Tobacco Internet Survey, a nationwide online survey conducted from February to March 2021, which also assessed items related to COVID-19 and public trust. We included 453 participants with a history of COVID-19. Participants' reports of their general trust in the national government and the related policies, attitudes toward COVID-19 vaccination, and the adherence to the preventive measures against SARS-CoV-2 spread were compared between COCOA users and non-users controlling for age, sex, and socioeconomic statuses by analysis of covariance. Mediation analysis was conducted to examine whether public trust mediates the associations of certain participants' characteristics with COCOA utilization. Results: Seventy-six percent (344/453) reported the COCOA utilization. Compared to non-users, the users were younger, more likely to be men and had a tendency to have higher education. They were more willing to get COVID-19 vaccination, adherent to public health measures against the spread of the SARS-Cov-2, and more likely to express trust in government in general and policies related to COVID-19 independent of age, sex, and the socioeconomic status. Trust in government did not mediate the associations of age and education with COCOA utilization. Conclusions: The utilization of digital contact tracing technology for the health of public during pandemic was related to the degree of trust in the government in Japan.

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  47. Gender Difference in Fear and Anxiety about and Perceived Susceptibility to COVID-19 in the Third Wave of Pandemic among the Japanese General Population: A Nationwide Web-Based Cross-Sectional Survey. Reviewed International journal

    Rio Sasaki, Atsuhiko Ota, Hiroshi Yatsuya, Takahiro Tabuchi

    International journal of environmental research and public health   Vol. 19 ( 23 )   2022.12

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    Existing research suggested gender differences in fear and anxiety about and perceived susceptibility to COVID-19 and previous infectious disease pandemics. We analyzed whether women felt fear and anxiety about and perceived susceptibility to COVID-19 more frequently than men in Japan. We conducted a cross-sectional analysis using internet survey data collected during the third wave of the pandemic in Japan. The subjects were enrolled from the Japanese general population: 11,957 men and 11,559 women. Fear and anxiety specifically related to COVID-19 were evaluated with the Japanese version of the Fear of COVID-19 Scale (FoCS). The question "How likely do you think you will be infected with COVID-19?" was used to assess the perceived susceptibility to COVID-19. Women had higher mean (standard deviation) FoCS scores [18.6 (5.6) vs. 17.5 (5.9), d = 0.190] and reported the median or higher FoCS score (57.4% vs. 51.4%, φ = 0.060) and perceived susceptibility (13.6% vs. 11.5%, φ = 0.032) more frequently than men. The odds ratios (95% confidence intervals) adjusted for age, having a spouse, comorbidities, watching commercial TV stations' news programs, employment status, and household income were 1.24 (1.17-1.32) and 1.27 (1.16-1.38), respectively. We observed that women were more anxious and fearful about and perceived the susceptibility to infectious diseases more frequently than men even one year after the pandemic occurred in Japan, although the effect size was small.

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  48. Association between long-term alcohol consumption and insomnia symptoms in civil servants: Aichi Workers' Cohort Study. Reviewed

    Motoi Terabe, Tsuyoshi Kitajima, Atsuhiko Ota, Hiroshi Yatsuya, Nakao Iwata

    Fujita medical journal   Vol. 8 ( 4 ) page: 103 - 107   2022.11

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    OBJECTIVES: The influence of habitual alcohol consumption on insomnia symptoms in healthy workers remains unclear. In this study, we evaluated the association between habitual alcohol consumption among civil servants and insomnia symptoms such as difficulty falling asleep, difficulty staying asleep, and tiredness after sleep, using longitudinal data. METHODS: We enrolled civil servants in a prospective cohort study who completed questionnaires at baseline. Of those, 2861 participants were revaluated in a 5-year follow-up survey. Insomnia symptoms during the past month were assessed using self-reporting. Alcohol drinking habits were assessed by querying the frequency of drinking alcohol as well as the amount of alcohol usually consumed per one occasion. RESULTS: Drinking alcohol every day was less likely to have difficulty falling asleep (odds ratio, 0.42 95% confidence interval, 0.20-0.89), and drinking alcohol 3 or more days a week was associated with difficulty staying asleep (odds ratio, 1.48; 95% confidence interval, 1.16-1.90). CONCLUSIONS: Drinking alcohol every day may produce subjective improvement in sleep onset. However, drinking alcohol 3 or more days a week may increase arousal during sleep, which contributes to reduced sleep quality. These results suggest the possibility that long-term daily habitual drinking may reinforce a sense of improvement in subjective sleep onset but may possibly induce sleep disturbance.

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  49. Long-term variability and change trend of systolic blood pressure and risk of type 2 diabetes mellitus in middle-aged Japanese individuals: findings of the Aichi Workers’ Cohort Study Reviewed International coauthorship International journal

    Zean Song, Yupeng He, Chifa Chiang, Abubakr A. A. Al-shoaibi, K. M. Saif-Ur-Rahman, Md Razib Mamun, Atsuko Aoyama, Yoshihisa Hirakawa, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Yuanying Li, Hiroshi Yatsuya

    Hypertension Research   Vol. 45 ( 11 ) page: 1772 - 1780   2022.11

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  50. Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case-control study. Reviewed International journal

    Tamie Nakajima, Hailan Wang, Yuan Yuan, Yuki Ito, Hisao Naito, Yoshiyuki Kawamoto, Kozue Takeda, Kiyoshi Sakai, Na Zhao, Hongling Li, Xinxiang Qiu, Lihua Xia, Jiabin Chen, Qifeng Wu, Laiyu Li, Hanlin Huang, Yukie Yanagiba, Hiroshi Yatsuya, Michihiro Kamijima

    Archives of toxicology   Vol. 96 ( 10 ) page: 2785 - 2797   2022.10

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    Occupational exposure to trichloroethylene (TCE) causes a systemic skin disorder with hepatitis known as TCE hypersensitivity syndrome (TCE-HS). Human Leukocyte Antigen (HLA)-B*13:01 is its susceptibility factor; however, the immunological pathogenesis of TCE-HS remains unknown. We herein examined the hypothesis that autoantibodies to CYP2E1 are primarily involved in TCE-HS. A case-control study of 80 TCE-HS patients, 186 TCE-tolerant controls (TCE-TC), and 71 TCE-nonexposed controls (TCE-nonEC) was conducted to measure their serum anti-CYP2E1 antibody (IgG) levels. The effects of TCE exposure indices, such as 8-h time-weighted-average (TWA) airborne concentrations, urinary metabolite concentrations, and TCE usage duration; sex; smoking and drinking habits; and alanine aminotransferase (ALT) levels on the antibody levels were also analyzed in the two control groups. There were significant differences in anti-CYP2E1 antibody levels among the three groups: TCE-TC > TCE-HS patients > TCE-nonEC. Antibody levels were not different between HLA-B*13:01 carriers and noncarriers in TCE-HS patients and TCE-TC. The serum CYP2E1 measurement suggested increased immunocomplex levels only in patients with TCE-HS. Multiple regression analysis for the two control groups showed that the antibody levels were significantly higher by the TCE exposure. Women had higher antibody levels than men; however, smoking, drinking, and ALT levels did not affect the anti-CYP2E1 antibody levels. Anti-CYP2E1 antibodies were elevated at concentrations lower than the TWA concentration of 2.5 ppm for TCE exposure. Since HLA-B*13:01 polymorphism was not involved in the autoantibody levels, the possible mechanism underlying the pathogenesis of TCE-HS is that TCE exposure induces anti-CYP2E1 autoantibody production, and HLA-B*13:01 is involved in the development of TCE-HS.

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  51. Association between irregular daily routine and risk of incident stroke and coronary heart disease in a large Japanese population. Reviewed International journal

    Takahiro Yoshizaki, Junko Ishihara, Ayaka Kotemori, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Kazumasa Yamagishi, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

    Scientific reports   Vol. 12 ( 1 ) page: 15750 - 15750   2022.9

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    Circadian misalignments have been linked to adverse cardiometabolic outcomes. However, the association between irregular daily routine and the risk of cardiovascular disease (CVD) remains unknown. We examined this association in a prospective study in Japan. The study included 78,115 Japanese participants aged 45-74 years. The self-reported daily routine was evaluated using the question, 'Is your daily routine or activity schedule regular?' The response (yes/no) was obtained as a binary variable. Cox proportional hazard regression analysis was used to estimate the hazard ratios and 95% confidence intervals for the association between an irregular daily routine and CVD incidence risk. Among the participants, 23.7% reported an irregular daily routine. During the mean follow-up period of 13.3 years, we observed 4641 CVD events. An irregular daily routine was significantly associated with increased risks of CVD and total stroke in women, but not in men. This positive association between an irregular daily routine and the risk of CVD was weak in the high vegetable and fruit consuming population. An irregular daily routine is positively associated with the risk of incident CVD, especially in women. These associations may be weak in populations that consume a diet rich in vegetables and fruits.

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  52. Diabetes management in people living with dementia in Japan: a qualitative exploration Reviewed International journal

    KM, SUR; HIRANO, Y; HIRAKAWA, Y; YATSUYA, H

    PSYCHOGERIATRICS   Vol. 22 ( 5 ) page: 728 - 735   2022.9

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    Background: Dementia and diabetes are highly prevalent among the older society in Japan. People living with dementia (PLWD) often face hurdles in managing diabetes. This study explored the perspectives of healthcare providers in Japan regarding diabetes management in PLWD. Methods: We conducted a qualitative study using in-depth interviews as a data collection method. A total of 15 physicians and nurses were interviewed. A qualitative content analysis of the codes was performed to generate the themes. Results: The major themes focused on the management of medications/therapeutic regimen, difficulties of continuing health care, emotional aspects of PLWD for adherence to lifestyle modification, and varying direction and degree of family support for diabetes care. Conclusion: PLWD in Japan face challenges in medication management, food restriction, and lifestyle modification. Policies to engage home visit care workers in medication management, consideration of the emotional aspect of PLWD, and utilisation of social support might help in the proper management of diabetes in PLWD.

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  53. Secondhand smoke and the risk of incident cardiovascular disease among never-smoking women. Reviewed International journal

    Yuka Kobayashi, Kazumasa Yamagishi, Isao Muraki, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada

    Preventive medicine   Vol. 162   page: 107145 - 107145   2022.9

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    The prospective association between secondhand smoke (SHS) and the risk of incident cardiovascular disease (CVD) remains unclear. This study was the first to examine the association between SHS and risks of ischemic heart disease (IHD), stroke, and total CVD in a large cohort in Asia. The study followed 24,232 never-smoking women aged 40-59 from around Japan (Akita, Iwate, Nagano, Niigata, Ibaraki, Kochi, Nagasaki, and Okinawa prefectures). Their husbands were classified into never, former, and current smokers. After adjustment for age, body mass index, alcohol consumption, histories of hypertension and diabetes mellitus, medication use for hyperlipidemia, menopausal status, and public health center areas, the hazard ratios (HRs) of CVD according to husbands' smoking status were estimated by Cox proportional hazards models. During the 440,360 person-years follow-up, 846 women had total CVDs (103 IHDs, 744 strokes). The proportional hazard assumption was not assured during the total follow-up from 1990 to 2012, but so was then the follow-up of < and ≥ 10 person-years were examined separately. The multivariable HRs (95% confidence intervals) associated with husbands' current versus non-current smoking was 2.02 (1.19-3.45) for IHD, 1.18 (0.98-1.42) for stroke, and 1.25 (1.05-1.49) for total CVD in the follow-up of ≥10 person-years. The SHS from husbands may raise the risk of IHD among middle-aged never-smoking women.

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  54. 母体特性と妊娠中期血清n3系多価不飽和脂肪酸濃度の関連

    金子 佳世, 伊藤 由起, 加藤 沙耶香, 榎原 毅, 八谷 寛, 上島 通浩

    日本公衆衛生学会総会抄録集   Vol. 81回   page: 207 - 207   2022.9

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  55. A comparative study of the work-family conflicts prevalence, their sociodemographic, family, and work attributes, and their relation to the self-reported health status in Japanese and Egyptian civil workers Reviewed International coauthorship International journal

    Omnyh Kamal Abd El Latief, Ehab Salah Eshak, Eman Mohamed Mahfouz, Hiroyasu Iso, Hiroshi Yatsuya, Eman Mohamed Sameh, Eman Ramadan Ghazawy, Sachiko Baba, Shimaa Anwer Emam, Ayman Soliman El-khateeb, Ebtesam Esmail Hassan

    BMC Public Health   Vol. 22 ( 1 ) page: 1490   2022.8

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    Abstract

    Background

    Cross-cultural studies studying work-family conflicts (W_F_Cs) are scarce. We compared the prevalence of W_F_Cs, factors correlated with them, and their association with self-rated health between Japan and Egypt.

    Methods

    Among 4862 Japanese and 3111 Egyptian civil workers recruited by a convenience sample in 2018/2019 and reported self-rated health status, we assessed the W_F_Cs by the Midlife Development in the US (MIDUS) and attributed them to sociodemographic, family, and work variables. We also evaluated the W_F_Cs’ gender- and country-specific associations with self-rated health by logistic regression analyses.

    Results

    W_F_Cs were more prevalent in Egyptian than in Japanese women (23.7% vs. 18.2%) and men (19.1% vs. 10.5%), while poor self-rated health was more prevalent in Japanese than Egyptians (19.3% and 17.3% vs. 16.9% and 5.5%). Longer working hours, shift work, and overtime work were positively associated with stronger work-to-family conflict (WFC). Whereas being single was inversely associated with stronger family-to-work conflict (FWC). Living with children, fathers, or alone in Japan while education in Egypt was associated with these conflicts. The OR (95% CI) for poor self-reported health among those with the strong, in reference to weak total W_F_Cs, was 4.28 (2.91–6.30) and 6.01 (4.50–8.01) in Japanese women and men and was 2.46 (1.75–3.47) and 3.11 (1.67–5.80) in Egyptian women and men.

    Conclusions

    Japanese and Egyptian civil workers have different prevalence and correlated factors of W_F_Cs and self-rated health. W_F_Cs were associated in a dose–response pattern with poor-self-rated health of civil workers in both countries.

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  56. Impact of the COVID-19 pandemic on national and prefectural health and nutrition examination surveys: A report by the Monitoring Report Committee of the Japanese Society of Public Health Reviewed

    KUBO Akiko, KUNO Kazue, MARUYAMA Koutatsu, TSUKINOKI Rumi, NODA Hiroyuki, EGAWA Ken'ichi, SHIBUYA Izumi, SEI Masako, CHIHARA Mieko, NISHINA Kazue, YATSUYA Hiroshi

    Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH)   Vol. 69 ( 8 ) page: 586 - 594   2022.8

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  57. Dietary Patterns Derived from Reduced Rank Regression Are Associated with the 5-Year Occurrence of Metabolic Syndrome: Aichi Workers’ Cohort Study Reviewed International journal

    Yuanying Li, Hiroshi Yatsuya, Chaochen Wang, Mayu Uemura, Masaaki Matsunaga, Yupeng He, Maythet Khine, Atsuhiko Ota

    Nutrients   Vol. 14 ( 15 ) page: 3019 - 3019   2022.8

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    The aim of the present study was to derive dietary patterns to explain variation in a set of nutrient intakes or in the measurements of waist circumference (WC) and fasting blood glucose (FBG) using reduced rank regression (RRR) and to prospectively investigate these patterns in relation to the risk of developing metabolic syndrome (MetS) and its components during the follow-up. The study participants were comprised of 2944 government employees aged 30–59 years without MetS. RRR was applied with 38 food groups as predictors and with two sets of response variables. The first set included intake of putatively beneficial nutrients, and the first factor retained was named the Healthy Dietary Pattern (HDP). The second one included baseline WC and FBG, and the first factor was named the Unhealthy Dietary Pattern (UHDP). Multivariable Cox proportional hazard model was used to estimate hazard ratio and 95% confidence intervals with adjustments for age, sex, total energy consumption and other potential confounders. During the 5-year median follow-up, we ascertained 374 cases of MetS. The HDP score was inversely associated with the incidence of MetS (p-trend = 0.009) and hypertension (p-trend = 0.002) and marginally significantly associated with elevated triglyceride and decreased high-density lipoprotein cholesterol (p-trend = 0.08). The UHDP score was linearly positively associated with the incidence of MetS and all its components (all p-trend &lt; 0.05). Both the HDP and UHDP predicted the development of MetS and its components.

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  58. Combined Exoscopic and Endoscopic Two-Step Keyhole Approach for Intracranial Meningiomas Reviewed International journal

    Tadashi Watanabe, Kenichiro Iwami, Yugo Kishida, Tetsuya Nagatani, Hiroshi Yatsuya, Shigeru Miyachi

    Current Oncology   Vol. 29 ( 8 ) page: 5370 - 5382   2022.8

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    The advantages of neuroendoscopic surgery are the wide viewing angle and the freedom of an axis of view with minimal surgical trauma. With the advent of the exoscope, which has similar advantages to endoscopy, such as a small body and ergonomically superior heads-up surgery, it has become possible to add a field of view that is similar to that of microsurgery to endoscopic surgery. By taking advantage of the features of these scopes, we report the usefulness of the minimally invasive combined exoscopic and endoscopic two-step keyhole approach (EEKA) for various types of meningiomas. We reviewed data from 34 consecutive cases of EEKA for various types of intracranial meningiomas compared with that of conventional microsurgery. All of the tumors were resected as planned without severe complications. Significantly better outcome data were obtained in terms of the blood loss and the surgical time in the EEKA group, in addition to the craniotomy size. The well-illuminated fine vision in the deep corners by the endoscope enabled radical resection of the tumors with minimum burden on the patients. This technique has the potential for minimally invasive surgery in intracranial meningioma patients, including the older population.

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  59. Influence of the COVID-19 pandemic on regular clinic visits and medication prescriptions among people with diabetes: Retrospective cohort analysis of health care claims. Reviewed International journal

    Toshiki Maeda, Takumi Nishi, Masataka Harada, Kozo Tanno, Naoyuki Nishiya, Kei Asayama, Nagako Okuda, Daisuke Sugiyama, Hiroshi Yatsuya, Akira Okayama, Hisatomi Arima

    Medicine   Vol. 101 ( 29 ) page: e29458   2022.7

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    The aim of this study was to investigate the effect of the COVID-19 pandemic on regular clinic visits among people with diabetes and to elucidate the factors related to visit patterns among these patients during the pandemic. This was a longitudinal study using anonymized insurance claims data from the Joint Health Insurance Society in Tokyo from October 2017 to September 2020. First, we identified patients with diabetes who were fully enrolled in the health plan from fiscal year 2017 until September 2020 and who were regularly receiving glucose-lowering medications (every 1-3 months) from October 2017 to September 2018. We divided follow-up into the pre-pandemic period (October 2018 to March 2020) and the pandemic period (April 2020 to September 2020). A multilevel logistic regression model was used to determine the risks of delayed clinic visits/medication prescriptions (i.e., >3 months after a previous visit/prescription) during the pandemic period. We identified 1118 study participants. The number of delayed clinic visits/medication prescriptions during the pre-pandemic and pandemic periods was 188/3354 (5.6%) and 125/1118 (11.2%), respectively. There was a significant increase in delayed clinic visits during the pandemic (adjusted odds ratio 3.68 (95% confidence interval 2.24 to 6.04, P < .001), even after controlling for confounding factors. We also found a significant interaction between sex and delayed visits; women had significantly fewer clinic visits during the COVID-19 pandemic than men. We clarified the relationship of the COVID-19 pandemic with delays in regular clinic visits and medication prescriptions among people with diabetes. The response to the COVID-19 pandemic differed between men and women.

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  60. High Maternal Total Cholesterol Is Associated With No-Catch-up Growth in Full-Term SGA Infants: The Japan Environment and Children's Study. Reviewed International journal

    Kayo Kaneko, Yuki Ito, Takeshi Ebara, Sayaka Kato, Taro Matsuki, Hazuki Tamada, Hirotaka Sato, Shinji Saitoh, Mayumi Sugiura-Ogasawara, Hiroshi Yatsuya, Michihiro Kamijima

    Frontiers in endocrinology   Vol. 13   page: 939366 - 939366   2022.7

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    Objectives: Infants born small for gestational age (SGA) with no catch-up growth (No-CU) are at high risk of intellectual and developmental disabilities. However, factors leading to No-CU among SGA infants are unclear. This study aimed to examine the association between maternal total cholesterol (TC) in mid-pregnancy and No-CU at 3 years among full-term SGA infants. Study Design: The Japan Environment and Children's Study (JECS) is a nationwide prospective birth cohort study. We extracted a total of 2,222 mothers and full-term SGA infants (length and/or weight <-2 standard deviation [SD]) without congenital abnormalities from the original JECS cohort comprising a total of 104,062 fetal records. According to the distribution of maternal TC in the entire cohort, participants were classified into nine groups per each fifth percentile with the 20th-79th percentiles (204-260 mg/dl) as the reference group. No-CU was defined by a Z-score of height at 3 years <-2 SD according to the growth standard charts for Japanese children. Multivariable-adjusted logistic regression models were carried out using multiple imputations. Additionally, a multiple-adjusted restricted cubic spline model was performed in the complete dataset. Results: A total of 362 (16.3%) children were No-CU at 3 years. After adjusting for the Z-score of birth weight, age of mother, smoking status, weight gain during pregnancy, breastfeeding and meal frequency at 2 years, and parents' heights, the odds ratio (95% confidence intervals) of No-CU was 2.95 (1.28-6.80) for children whose maternal TC levels were in the highest category (≥294 mg/dl), compared to the reference group. A multiple-adjusted restricted cubic spline model showed a non-linear trend of the significant association between high maternal TC and No-CU (p for linear trend = 0.05, p for quadratic trend <0.05). Conclusion: High maternal TC at mid-pregnancy was associated with No-CU among SGA infants. Such infants should be carefully followed up to introduce appropriate growth hormonal treatment. The findings may support previous animal experimental studies which indicated that maternal high-fat diet exposure induces impairment of growth and skeletal muscle development in the offspring. Future studies are required to elucidate the detailed mechanism.

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  61. Endoscopic sphincterotomy and endoscopic biliary stenting do not affect the sensitivity of transpapillary forceps biopsy for the diagnosis of bile duct adenocarcinoma Reviewed International journal

    Aoki, T; Ohno, E; Ishikawa, T; Mizutani, Y; Iida, T; Yamao, K; Yamamura, T; Furukawa, K; Nakamura, M; Honda, T; Ishigami, M; Yatsuya, H; Kawashima, H

    BMC GASTROENTEROLOGY   Vol. 22 ( 1 ) page: 329   2022.7

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    Background: The pathological evaluation of tissues with cholangitis is considered difficult, which can often occur after endoscopic sphincterotomy (EST) and endoscopic biliary stenting (EBS). This study aimed to evaluate the influence of a history of EST and EBS on the sensitivity of transpapillary forceps bile duct biopsy (TB) for bile duct adenocarcinoma. Methods: This retrospective study included consecutive cases of bile duct adenocarcinoma in which TB was performed before July 2020 until the number exceeded that required to support statistical and noninferiority analyses of the sensitivity of TB between patients with and without each variable. The incidence of postprocedural adverse events related to each factor was also investigated. Results: Overall, 280 samples were required in each group, and 437 subjects (792 samples) were included. The sensitivity of TB was 63.6% for the subjects and 59.6% for the biopsy samples. For the biopsy samples, the sensitivity did not differ significantly between samples from patients with and without a history of EST (59.1% vs. 58.9%, P = 0.952) and EBS (62.1% vs. 55.4%, P = 0.065). The sensitivity was significantly higher for samples from patients with jaundice (67.9% vs. 57.0%, P = 0.008). There were significantly fewer procedure-related adverse events in patients with a history of EST (10.8% vs. 19.0%, P = 0.017) and EBS (12.0% vs. 21.7%, P = 0.005). Conclusions: A history of EST or EBS did not influence sensitivity of TB but significantly decreased the incidence of adverse events. To safely and reliably perform TB to diagnose bile duct adenocarcinoma, planning, including for EST and EBS, is necessary.

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  62. Early impact of the spread of the novel coronavirus infection on medical, long-term care and welfare sites in Japan: A qualitative study Reviewed

    Tokai Journal of Public Health   Vol. 10 ( 1 ) page: 85 - 94   2022.7

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    <p>Objectives</p><p>This study aimed to describe the structure of problems that occurred in the field of medical, long-term care and welfare under the unprecedented situation of the early stage of the spread of novel coronavirus.</p><p>Methods</p><p>We conducted the online interview from April to May in 2020, targeting 27 workers on medical, long-term care, and welfare sites. The semi-structured interview using an interview guide was conducted in a free-answer format. A verbatim record was created from the recorded interview content, and the text data was analyzed by qualitative content analysis.</p><p>Results</p><p>We extracted 126 types of the meaning unit and the following four themes. (1) anxiety and dissatisfaction with information deficiency and insufficient information sharing, (2) stress of medical workers due to the double burden of overwork and discrimination from society, (3) the measures against loneliness and poverty, and (4) difficulty in infection prevention measures.</p><p>Conclusion</p><p>Under the unprecedented situation in the early stage of novel coronavirus infection, shortages of highly reliable information as well as of medical materials were particularly serious. Preventive measures against stress for medical staff and the livelihood support for loneliness and poverty were found to be important.</p>

    DOI: 10.24802/tpha.2022-02

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  63. 健診で血圧高値を指摘された高血圧症患者の疾患と治療に対する認識と態度 Reviewed

    洪 英在, 平川 仁尚, 犬飼 麻里子, 水野 晴子, 江 啓発, 八谷 寛

    東海公衆衛生雑誌   Vol. 10 ( 1 ) page: 180 - 186   2022.7

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    <p><b>目的</b> 適切に血圧がコントロールされている人を増やすためには, コントロール不良の高血圧症患者に焦点を当て, その要因を明らかにする必要がある。高血圧症は無症候性であることが多いため, 患者本人の疾患や治療に関する認識への働きかけを行うことが重要であるが, そうした研究は少ない。本研究は, 健診でII度以上の血圧高値を指摘された高血圧患者 (すなわち, 良好なコントロール状態にあるとは判断されない高血圧症患者) の疾患と治療に対する認識や態度を探索することを目的とした。</p><p><b>方法</b> 対象者は, 愛知県岩倉市が2019年度, 2020年度, 2021年度に実施した特定健診受診者の中から, 一度でも収縮期血圧160mmHg以上または拡張期血圧100mmHg以上であった300名に対して研究参加を呼び掛け, 同意が得られた13名とした。データ収集は1回約30分間の1対1の半構造化面接により行われた。データ分析は, 質的内容分析により行われた。</p><p><b>結果</b> 対象者の性別は女性5名, 平均年齢は69.2歳 (60-74歳) であった。2名がBMI 25kg/m<sup>2</sup>以上の肥満であったがBMI 35kg/m<sup>2</sup>以上の高度肥満は存在しなかった。13名ともに高血圧症での医療機関通院歴を有し, 8名がかかりつけ医から降圧剤を処方されていた。質的分析の結果, 高血圧に対するイメージ, 治療に関する認識, ピアから受ける影響, 患者からみたかかりつけ医の診療姿勢, 実際に行動変容することの難しさ, の5テーマが抽出された。対象者の中には, 高血圧症に対して重大性を認識していないか, 生活習慣改善に向けて行動を起こすメリットを感じていないようであった。また, 降圧剤について, 必要性を感じず, 副作用を危惧していた。こうした認識は, ピア, つまり同じ疾患を持つ家族・同僚や, かかりつけ医の診療姿勢から影響を受けていた。</p><p><b>結論</b> コントロールが良好でない可能性がある高血圧症患者の疾患と治療に対する認識と態度として, 行動変容の準備性の低さ, 治療内容に関する否定的な認識, ピアからの影響の大きさ, かかりつけ医の診療姿勢への転嫁的態度が存在する可能性があると考えられた。</p>

    DOI: 10.24802/tpha.2022-13

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  64. 特定健診およびレセプトデータを用いた愛知県岩倉市における心血管疾患発症リスクおよび人口寄与危険割合に関するコホート研究 Reviewed

    江 啓発, 藤社 紗梨, 水野 晴子, 平川 仁尚, 八谷 寛

    東海公衆衛生雑誌   Vol. 10 ( 1 ) page: 166 - 179   2022.7

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    <p><b>目的</b> 特定健診とレセプトの分析に基づき保健事業の効果や効率を高めていくこと (データヘルス計画) が保険者には求められているが、課題設定や被保険者への情報提供に資する実態把握には特定健診受診率や有所見者割合、高額医療費者数等の横断的な検討が中心である。そこで本研究は、愛知県岩倉市国民健康保険 (国保) 加入者の特定健診とその後の経年的なレセプト情報を突合したコホート研究データを用い、心血管疾患発症リスクおよび人口寄与危険割合の推定を試みた。</p><p><b>方法</b> 岩倉市国保加入者のうち、2013年から2018年までの5年間に特定健診を1回以上受診した者を対象とし、最初の受診年をベースラインとした。ベースライン以前に心血管疾患の既往歴のある者および問診データに欠損値の多い者を除外した6,496名 (男性2,722名、女性3,774名) を解析対象とした。レセプト情報を用いて追跡期間中の心血管疾患の発症を把握し、特定健診結果から把握した危険因子と全心血管疾患、心筋梗塞、脳卒中の関連を性・年齢および危険因子を相互に調整したCox比例ハザードモデルで検討した。また、多変量調整ハザード比(HR)と発症者における危険因子の割合から人口寄与危険割合を推定した。</p><p><b>結果</b> 解析対象者のベースライン時平均年齢は62.5歳であった。追跡期間中の全心血管疾患、心筋梗塞、脳卒中の発症者数はそれぞれ149名、58名、91名であった。女性に比し男性 (HR : 2.0、95%信頼区間 (CI) : 1.4-2.8)、非現喫煙者に比し現喫煙者 (HR : 1.7、95% CI : 1.1-2.5) は心血管疾患発症リスクが約2倍高かった。非高血圧に比しI度およびII度以上高血圧の心血管疾患発症のハザード比はそれぞれ1.7 (95% CI : 1.1-2.4)、2.3 (95% CI : 1.5-3.5) であった。また、糖尿病 (HR : 2.3、95% CI : 1.4-3.9)、メタボリックシンドローム該当者 (HR : 1.6、95% CI : 1.1-2.3) ともに約2倍の心血管疾患発症リスクと関連した。心血管疾患の人口寄与危険割合は高血圧 (I度以上) で27.2%と最も高く、次いで喫煙11.3% メタボリックシンドローム10.5%、糖尿病10.2%であった。</p><p><b>結論</b> 高血圧、喫煙、糖尿病、メタボリックシンドロームは性、年齢、その他の危険因子に独立して心血管疾患発症リスク上昇と有意に関連した。心血管疾患の人口寄与危険割合は高血圧で最も高かった。</p>

    DOI: 10.24802/tpha.2022-12

    CiNii Research

  65. Association between C-reactive protein and risk of overall and 18 site-specific cancers in a Japanese case-cohort Reviewed

    Suzuki S., Katagiri R., Yamaji T., Sawada N., Imatoh T., Ihira H., Inoue M., Tsugane S., Iwasaki M., Miyamoto Y., Abe S.K., Tanaka S., Moriya T., Minamizono T., Shirai Y., Kuniyoshi H., Yoshimi T., Sonoda H., Tagami T., Ando T., Kimura T., Kokubo Y., Yamagishi K., Mizoue T., Nakamura K., Takachi R., Ishihara J., Iso H., Kitamura T., Saito I., Yasuda N., Mimura M., Sakata K., Noda M., Goto A., Yatsuya H.

    British Journal of Cancer   Vol. 126 ( 10 ) page: 1481 - 1489   2022.6

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    Background: Evidence of the association between chronic low-grade inflammation, as reflected by C-reactive protein (CRP) measurements, and cancer risk is equivocal. Specifically, few studies have examined this in uncommon cancers and Asian populations. Methods: We utilised a case-cohort design consisting of multi-types of cancer (N = 3608), and a random subcohort (N = 4432) in a Japanese large population-based study, with a median follow-up time of 15.6 years, and measured baseline plasma CRP using high sensitivity assay. The hazard ratios (HRs) were estimated using weighted Cox proportional hazards methods. Results: The multivariable-adjusted HR (95% confidence interval) for the top quartile of CRP was 1.28 (1.11‒1.48) (Ptrend < 0.001) for overall cancer compared to the bottom quartile of CRP. Among site-specific cancers, higher CRP levels were associated with an increased risk of colorectal, lung, breast, biliary tract, and kidney cancer, and leukaemia. These positive associations remained among participants after >3 years’ follow-up. Furthermore, subgroup analyses for overall cancer robustly showed a positive association with CRP levels, regardless of sex and obesity. Conclusion: Our consistent findings suggested that chronic low-grade inflammation measured by CRP is associated with the risk of cancer.

    DOI: 10.1038/s41416-022-01715-8

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  66. Stoma creation is associated with a low incidence of midline incisional hernia after colorectal surgery: the "fighting over the fascia" theory concerning the incision and stoma hole. Reviewed

    Noriaki Ohara, Kay Uehara, Atsushi Ogura, Masanori Sando, Toshisada Aiba, Yuki Murata, Takashi Mizuno, Kokuryo Toshio, Yukihiro Yokoyama, Satoko Ishigaki, Yuanying Li, Hiroshi Yatsuya, Tomoki Ebata

    Surgery today   Vol. 52 ( 6 ) page: 953 - 963   2022.6

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    PURPOSE: Parastomal hernia (PH) develops more frequently than incisional hernia (IH) after colorectal surgery with stoma. This study evaluated our hypothesis that inward traction of the fascia when closing a midline incision widens the stoma hole and increases the incidence of PH. METHODS: A total of 795 patients who underwent colorectal resection between 2006 and 2016 were retrospectively analyzed. The risk classification was constructed from IH risk factors extracted from the non-stoma group. Then, the classification was extrapolated to the stoma group for predicting midline IH and PH. RESULTS: The incidence of IH was 5.3% in the stoma group and 12.5% in the non-stoma group (p = 0.005). PH developed in 19.6% of 97 patients with permanent stoma. The risk classification was able to predict PH without a significant difference but was well balanced in patients with permanent stoma; however, it failed to predict IH in the stoma group. CONCLUSION: The risk classification constructed from the non-stoma group was useful for predicting not midline IH but PH, suggesting that the stoma site was the most vulnerable for herniation. The "fighting over the fascia" theory between the midline incision and stoma hole may explain the causal relationship between the midline IH and PH.

    DOI: 10.1007/s00595-021-02434-y

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  67. Prioritization and sequential exclusion of articles in systematic reviews Reviewed International coauthorship International journal

    Saif-Ur-Rahman, KM; Hasan, M; Hossain, S; Anwar, I; Hirakawa, Y; Yatsuya, H

    CAMPBELL SYSTEMATIC REVIEWS   Vol. 18 ( 2 ) page: e1229   2022.6

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    It is difficult to match the causes of exclusion among two independent review authors after screening the title and abstract or full texts in systematic reviews. We have proposed the prioritization and sequential exclusion approach to reduce the subjectivity in reporting reasons for exclusion. This approach might reduce the burden of mismatched numbers while describing the cause of exclusion.

    DOI: 10.1002/cl2.1229

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  68. Implementation strategies for the patient safety reporting system using Consolidated Framework for Implementation Research: a retrospective mixed-method analysis Reviewed

    Koike, D; Ito, M; Horiguchi, A; Yatsuya, H; Ota, A

    BMC HEALTH SERVICES RESEARCH   Vol. 22 ( 1 ) page: 409   2022.3

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    Background: Healthcare-related adverse events occur because of complex healthcare systems. The patient safety reporting system is a core component of patient safety initiatives in hospitals. However, hospital management often encounters a cultural barrier with its implementation and struggles to overcome the same. Implementation science would be useful for analysing implementation strategies. This study determines the effects of the implemented strategy on an increase in the number of patient safety reports and the determinants of successful implementation, using the implementation framework. Methods: Mixed method analysis was performed in Fujita Health University Hospital (FHUH), a large volume hospital in Japan. We identified strategies to implement the patient safety reporting system by scrutinising internal documents using the Consolidated Framework for Implementation Research (CFIR). The electronic reporting systems developed in 2004 in the FHUH and the number of reports were analysed using the staff data and hospital volumes. Results: Reports (n = 110,058) issued between April 2004 and March 2020 were analysed. The number of reports increased from 2004 to 2008 and from 2013 to 2019, reaching 14,037 reports per year. Between 2009 and 2012, the FHUH experienced a stagnation period where the number of reports were not increasing. From the qualitative materials, we identified 74 strategies which contributed to the implementation of the patient safety reporting system. Among these, the domain of ‘intervention characteristics’ in the CFIR contained 12 strategies, ‘outer settings’ contained 20, ‘inner settings’ contained 21, ‘characteristics of individuals’ contained 8, and ‘process’ contained 13. There were two concentrated periods of the implemented strategies, the number was 17 in 2007 and 10 in 2016. These concentrated periods preceded a remarkable increase in the number of patient safety reports. Conclusions: A safety culture had been fostered in FHUH in the study period. A relationship between number of strategies and development of a reporting culture was observed. The intensity of adequate strategies was needed for implementation of patient safety reporting system. Therefore, the implementation framework is useful for analysing patient safety initiatives for safety culture.

    DOI: 10.1186/s12913-022-07822-9

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  69. Low Density Lipoprotein Cholesterol Associations With The Risk Of Coronary Heart Disease And Stroke Among Middle-aged Japanese Workers: Analysis Using Inverse Probability Weighting

    Al-shoaibi, AA; Li, YY; Chiang, C; Hirakawa, Y; Song, Z; Saif-Ur-Rahman, KM; Masako, S; Masaaki, M; Aoyama, A; Tamakoshi, K; Ota, A; Yatsuya, H

    CIRCULATION   Vol. 145   2022.3

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    DOI: 10.1161/circ.145.suppl_1.EP32

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  70. Smoking cessation, weight gain and risk of cardiovascular disease. Reviewed International journal

    Xiaowen Wang, Jia-Yi Dong, Renzhe Cui, Isao Muraki, Kokoro Shirai, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

    Heart (British Cardiac Society)   Vol. 108 ( 5 ) page: 375 - 381   2022.3

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    OBJECTIVE: To examine whether the relationship between smoking cessation and risk of cardiovascular disease (CVD) was modified by weight gain. METHODS: A total of 69 910 participants (29 650 men and 46 260 women) aged 45-74 years were grouped into six groups by smoking status in the first and 5-year surveys: sustained smokers, recent quitters according to postcessation weight gain (no weight gain, 0.1-5.0 kg, >5.0 kg), long-term quitters and never smokers. Quitting smoking within and longer than 5 years were defined as recent and long-term quitters, respectively. We used Cox proportional hazard models to estimate the HR for incident CVD, coronary heart disease (CHD) and stroke. RESULTS: We identified 4023 CVDs (889 CHDs and 3217 strokes) during a median of 14.8 years of follow-up. Compared with sustained smokers, the multivariable HR (95% CI) for CVD was 0.66 (0.52 to 0.83) for recent quitters without weight gain, 0.71 (0.55 to 0.90) for recent quitters with weight gain of 0.1-5.0 kg, 0.70 (0.44 to 1.10) for recent quitters with weight gain of >5.0 kg, 0.56 (0.49 to 0.64) for long-term quitters, and 0.60 (0.55 to 0.66) for never smokers. The analysis restricted to men showed a similar association. Prespecified analysis by age suggested that recent quitters overall had a lower HR for CVD among those aged <60 years vs ≥60 years. Similar patterns of association were observed in CHD and stroke. CONCLUSIONS: Postcessation weight gain did not attenuate the protective association between smoking cessation and risk of CVD.

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  71. 職業性ストレスと退職後の認知機能低下に関する縦断的研究 愛知職域コホート研究

    中島 啓裕, 江 啓発, 平川 仁尚, He Yupeng, 霜田 真子, 玉腰 浩司, 八谷 寛

    産業ストレス研究   Vol. 29 ( 1 ) page: 169 - 169   2022.3

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  72. Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019 Reviewed International coauthorship

    Cousin, E; Duncan, BB; Stein, C; Ong, KL; Vos, T; Abbafati, C; Abbasi-Kangevari, M; Abdelmasseh, M; Abdoli, A; Abd-Rabu, R; Abolhassani, H; Abu-Gharbieh, E; Accrombessi, MMK; Adnani, QES; Afzal, MS; Agarwal, G; Agrawaal, KK; Agudelo-Botero, M; Ahinkorah, BO; Ahmad, S; Ahmad, T; Ahmadi, K; Ahmadi, S; Ahmadi, A; Ahmed, A; Salih, YA; Akande-Sholabi, W; Akram, T; Al Hamad, H; Al-Aly, Z; Alcalde-Rabanal, JE; Alipour, V; Aljunid, SM; Al-Raddadi, RM; Alvis-Guzman, N; Amini, S; Ancuceanu, R; Andrei, T; Andrei, CL; Anjana, RM; Ansar, A; Antonazzo, IC; Antony, B; Anyasodor, AE; Arabloo, J; Arizmendi, D; Armocida, B; Artamonov, AA; Arulappan, J; Aryan, Z; Asgari, S; Ashraf, T; Astell-Burt, T; Atorkey, P; Atout, MMW; Ayanore, MA; Badiye, AD; Baig, AA; Bairwa, M; Baker, JL; Baltatu, OC; Banik, PC; Barnett, A; Barone, MTU; Barone-Adesi, F; Barrow, A; Bedi, N; Belete, R; Belgaumi, UI; Bell, AW; Bennett, DA; Bensenor, IM; Beran, D; Bhagavathula, AS; Bhaskar, S; Bhattacharyya, K; Bhojaraja, VS; Bijani, A; Bikbov, B; Birara, S; Bodolica, V; Bonny, A; Brenner, H; Briko, NI; Butt, ZA; dos Santos, FLC; Camera, LA; Campos-Nonato, IR; Cao, Y; Cao, C; Cerin, E; Chakraborty, PA; Chandan, JS; Chattu, VK; Chen, SM; Choi, JYJ; Choudhari, SG; Chowdhury, EK; Chu, DT; Corso, B; Dadras, O; Dai, XC; Damasceno, AAM; Dandona, L; Dandona, R; Dávila-Cervantes, CA; De Neve, JW; Denova-Gutiérrez, E; Dhamnetiya, D; Diaz, D; Ebtehaj, S; Edinur, HA; Eftekharzadeh, S; El Sayed, I; Elgendy, IY; Elhadi, M; Elmonem, MA; Faisaluddin, M; Farooque, U; Feng, XQ; Fernandes, E; Fischer, F; Flood, D; Freitas, M; Gaal, PA; Gad, MM; Gaewkhiew, P; Getacher, L; Ghafourifard, M; Gheshlagh, RG; Ghashghaee, A; Ghith, N; Ghozali, G; Gill, PS; Ginawi, IA; Glushkova, EV; Golechha, M; Gopalani, SV; Guimaraes, RA; Das Gupta, R; Gupta, R; Gupta, VK; Gupta, VB; Gupta, S; Habtewold, TD; Hafezi-Nejad, N; Halwani, R; Hanif, A; Hankey, GJ; Haque, S; Hasaballah, AI; Hasan, SS; Hashi, A; Hassanipour, S; Hay, SI; Hayat, K; Heidari, M; Hossain, MBH; Hossain, S; Hosseini, M; Hoveidamanesh, S; Huang, JJ; Humayun, A; Hussain, R; Hwang, BF; Ibitoye, SE; Ikuta, KS; Inbaraj, LR; Iqbal, U; Islam, MS; Islam, SMS; Islam, RM; Ismail, NE; Isola, G; Itumalla, R; Iwagami, M; Iyamu, IO; Jahani, MA; Jakovljevic, M; Jayawardena, R; Jha, RP; John, O; Jonas, JB; Joo, T; Kabir, A; Kalhor, R; Kamath, A; Kanchan, T; Kandel, H; Kapoor, N; Kayode, GA; Kebede, SA; Keshavarz, P; Keykhaei, M; Khader, YS; Khajuria, H; Khan, MAB; Khan, MN; Khan, M; Khater, AM; Khoja, TAM; Khubchandani, J; Kim, MS; Kim, YJ; Kimokoti, RW; Kisa, S; Kisa, A; Kivimäki, M; Korshunov, VA; Korzh, O; Koyanagi, A; Krishan, K; Defo, BK; Kumar, GA; Kumar, N; Kusuma, D; La Vecchia, C; Lacey, B; Larsson, AO; Lasrado, S; Lee, WC; Lee, CB; Lee, PH; Lee, SWH; Li, MC; Lim, SS; Lim, LL; Lucchetti, G; Majeed, A; Malik, AA; Mansouri, B; Mantovani, LG; Martini, S; Mathur, P; McAlinden, C; Mehedi, N; Mekonnen, T; Menezes, RG; Mersha, AG; Jonasson, JM; Miazgowski, T; Michalek, IM; Mirica, A; Mirrakhimov, EM; Mirza, AZ; Mithra, P; Mohammadian-Hafshejani, A; Mohammadpourhodki, R; Mohammed, A; Mokdad, AH; Molokhia, M; Monasta, L; Moni, MA; Moradpour, F; Moradzadeh, R; Mostafavi, E; Mueller, UO; Murray, CJL; Mustafa, A; Nagel, G; Nangia, V; Naqvi, AA; Nayak, BP; Nazari, J; Ndejjo, R; Negoi, RI; Kandel, N; Nguyen, CT; Nguyen, HLT; Noubiap, JJ; Nowak, C; Oancea, B; Odukoya, OO; Oguntade, AS; Ojo, TT; Olagunju, AT; Onwujekwe, OE; Ortiz, A; Owolabi, MO; Palladino, R; Panda-Jonas, S; Pandi-Perumal, SR; Pardhan, S; Parekh, T; Parvizi, M; Pepito, VCF; Perianayagam, A; Petcu, IR; Pilania, M; Podder, V; Polibin, RV; Postma, MJ; Prashant, A; Rabiee, N; Rabiee, M; Rahimi-Movaghar, V; Rahman, MA; Rahman, MM; Rahman, M; Rahmawaty, S; Rajai, N; Ram, P; Rana, J; Ranabhat, K; Ranasinghe, P; Rao, CR; Rao, S; Rawaf, S; Rawaf, DL; Rawal, L; Renzaho, AMN; Rezaei, N; Rezapour, A; Riahi, SM; Ribeiro, D; Rodriguez, JAB; Roever, L; Rohloff, P; Rwegerera, GM; Ryan, PM; Saber-Ayad, MM; Sabour, S; Saddik, B; Moghaddam, SS; Sahebkar, A; Sahoo, H; Saif-Ur-Rahman, K; Salimzadeh, H; Samaei, M; Sanabria, J; Santric-Milicevic, MM; Sathian, B; Sathish, T; Schlaich, MP; Seidu, AA; Sekerija, M; Kumar, NS; Seylani, A; Shaikh, MA; Shamshad, H; Shawon, MSR; Sheikhbahaei, S; Shetty, JK; Shiri, R; Shivakumar, KM; Shuval, K; Singh, JA; Singh, A; Skryabin, VY; Skryabina, AA; Sofi-Mahmudi, A; Soheili, A; Sun, J; Szerencsés, V; Szócska, M; Tabarés-Seisdedos, R; Tadbiri, H; Tadesse, EG; Tariqujjaman, M; Thankappan, KR; Thapar, R; Thomas, N; Timalsina, B; Tobe-Gai, R; Tonelli, M; Tovani-Palone, MR; Tran, BX; Tripathy, JP; Car, LT; Tusa, BS; Uddin, R; Upadhyay, E; Tahbaz, SV; Valdez, PR; Vasankari, TJ; Verma, M; Villalobos-Daniel, VE; Vladimirov, SK; Vo, B; Vu, GT; Vukovic, R; Waheed, Y; Wamai, RG; Werdecker, A; Wickramasinghe, ND; Winkler, AS; Wubishet, BL; Xu, XY; Xu, SW; Jabbari, SHY; Yatsuya, H; Yaya, S; Yazie, TSY; Yi, SY; Yonemoto, N; Yunusa, I; Zadey, S; Bin Zaman, S; Zamanian, M; Zamora, N; Zastrozhin, MS; Zastrozhina, A; Zhang, ZJ; Zhong, CW; Zmaili, M; Zumla, A; Naghavi, M; Schmidt, MI

    LANCET DIABETES & ENDOCRINOLOGY   Vol. 10 ( 3 ) page: 177 - 192   2022.3

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    Background: Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990–2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings: In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r2=0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (−28·4 to −2·9) for all diabetes, and by 21·0% (–33·0 to −5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (−13·6% [–28·4 to 3·4]) and for type 1 diabetes (−13·6% [–29·3 to 8·9]). Interpretation: Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations. Funding: Bill & Melinda Gates Foundation.

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  73. Everyday wishes of older people living with dementia in care planning: a qualitative study Reviewed

    Md Razib Mamun, Yoshihisa Hirakawa, KM Saif-Ur-Rahman, Tomoka Sakaguchi, Chifa Chiang, Hiroshi Yatsuya

    BMC Health Services Research   Vol. 22 ( 1 ) page: 184   2022.2

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    Abstract

    Background

    The dementia care policy in Japan emphasizes the views of people living with dementia in care planning. An exploration of the everyday wishes of older people living with dementia can help clarify their priorities and assist in improving dementia care. This study aimed to explore the everyday wishes of older people living with dementia in Japan.

    Methods

    This qualitative study was conducted in Aichi prefecture in Japan. Older people with mild to moderate dementia were considered for inclusion. Participants were recruited from a dementia outpatient clinic. In-depth interviews were conducted with 36 participants in the same dementia outpatient clinic from January to October 2019. Audio-recorded interviews were transcribed verbatim. Inductive content analysis was carried out to analyze the data.

    Findings

    Participants expressed their everyday wishes within five themes (desire of being connected, freedom to decide, involvement in activities, status quo, and self-reliance). Older people living with dementia loved the connection with their family and wanted to have an enjoyable life by engaging in several activities without others’ interference. They desired to maintain the status quo and not be a burden to others.

    Conclusions

    This study provides evidence on the everyday wishes of people living with dementia. Identified wishes are mostly on emotional aspects of their daily lives. The findings of our study might help provide care for the people living with dementia considering their wishes. Further exploration, including people with severe dementia, is needed.

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  74. Age and sex differences in factors associated with hypertension among an urban poor population in Bangladesh Reviewed

    Al-Shoaibi, AAA; Chiang, CF; Khalequzzaman, M; Choudhury, SR; Hirakawa, Y; Islam, SS; Aoyama, A; Yatsuya, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page: 69 - 79   2022.2

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    This study explores the differences in factors associated with hypertension between younger and older subjects in an urban slum community in Bangladesh. We analyzed the data of 1,008 men and 1,001 women obtained from a cross-sectional survey conducted between October 2015 and April 2016. Multivariable logistic regression models were stratified by age (18 to 44 and 45 to 64 years) in men and women separately. The multivariable model included age (continuous) and the following categorical variables simultaneously: education duration, marital status, tobacco smoking, smokeless tobacco use, total physical activity, body mass index (BMI), waist circumference, and the blood levels of glycated hemoglobin (HbA1c), triglycerides, high and low-density lipoprotein (HDL and LDL) cholesterol. Hypertension was defined as the presence of either blood pressure ≥140/90 mmHg or the use of antihypertensive medication. The prevalence of hypertension was 13.0% (younger men), 14.6% (younger women), 35.6% (older men), and 38.7% (older women). In younger men, higher waist circumference and increased LDL cholesterol levels were significantly associated with hypertension. In older men, physical activity was the only significant factor that was inversely associated with hypertension. In younger women, higher BMI, increased HbA1c, triglycerides, and LDL cholesterol levels were associated with hypertension. In older women, a higher HbA1c was the only factor significantly associated with hypertension. These findings suggest that public health interventions to prevent hypertension may require different approaches according to sex and age groups within the poor urban population in Bangladesh.

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  75. Comparison of laminoplasty and posterior fusion surgery for cervical ossification of posterior longitudinal ligament Reviewed

    Nakashima, H; Imagama, S; Yoshii, T; Egawa, S; Sakai, K; Kusano, K; Nakagawa, Y; Hirai, T; Wada, K; Katsumi, K; Fujii, K; Kimura, A; Furuya, T; Kanchiku, T; Nagamoto, Y; Oshima, Y; Nagoshi, N; Ando, K; Takahata, M; Mori, K; Nakajima, H; Murata, K; Matsunaga, S; Kaito, T; Yamada, K; Kobayashi, S; Kato, S; Ohba, T; Inami, S; Fujibayashi, S; Katoh, H; Kanno, H; Li, YY; Yatsuya, H; Koda, M; Kawaguchi, Y; Takeshita, K; Matsumoto, M; Yamazaki, M; Okawa, A

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 748   2022.1

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    This prospective multicenter study, established by the Japanese Ministry of Health, Labour and Welfare and involving 27 institutions, aimed to compare postoperative outcomes between laminoplasty (LM) and posterior fusion (PF) for cervical ossification of the posterior longitudinal ligament (OPLL), in order to address the controversy surrounding the role of instrumented fusion in cases of posterior surgical decompression for OPLL. 478 patients were considered for participation in the study; from among them, 189 (137 and 52 patients with LM and PF, respectively) were included and evaluated using the Japanese Orthopaedic Association (JOA) scores, the JOA Cervical Myelopathy Evaluation Questionnaire (JOACMEQ), and radiographical measurements. Basic demographic and radiographical data were reviewed, and the propensity to choose a surgical procedure was calculated. Preoperatively, there were no significant differences among the participants in terms of patient backgrounds, radiographical measurements (K-line or cervical alignment on X-ray, OPLL occupation ratio on computed tomography, increased signal intensity change on magnetic resonance imaging), or clinical status (JOA score and JOACMEQ) after adjustments. The overall risk of perioperative complications was found to be lower with LM (odds ratio [OR] 0.40, p = 0.006), and the rate of C5 palsy occurrence was significantly lower with LM (OR 0.11, p = 0.0002) than with PF. The range of motion (20.91° ± 1.05° and 9.38° ± 1.24°, p < 0.0001) in patients who had PF was significantly smaller than in those who had LM. However, multivariable logistic regression analysis showed no significant difference among the participants in JOA score, JOA recovery rate, or JOACMEQ improvement at two years. In contrast, OPLL progression was greater in the LM group than in the PF group (OR 2.73, p = 0.0002). Both LM and PF for cervical myelopathy due to OPLL had resulted in comparable postoperative outcomes at 2 years after surgery.

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  76. Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study Reviewed International journal

    Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi

    Journal of Atherosclerosis and Thrombosis   Vol. 29 ( 10 ) page: 1547 - 1562   2022

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    <p> <b>Aim:</b> We aimed to examine the association of obesity-related cancer and cardiovascular disease (CVD) with body mass index (BMI) and the estimated population attributable fraction in lean Asians.</p><p><b>Methods:</b> We studied 102,535 participants aged 40–79 years without histories of cancer or CVD at baseline between 1988 and 2009. The cause-specific hazard ratios (csHRs) of BMI categories (<18.5, 18.5–20.9, 21.0–22.9 [reference], 23.0–24.9, 25.0–27.4, and ≥ 27.5 kg/m<sup>2</sup>) were estimated for each endpoint. The events considered were mortalities from obesity-related cancer (esophageal, colorectal, liver, pancreatic, kidney, female breast, and endometrial cancer) and those from CVD (coronary heart disease and stroke). Population attributable fractions (PAFs) were calculated for these endpoints.</p><p><b>Results:</b> During a 19.2-year median follow-up, 2906 died from obesity-related cancer and 4532 died from CVD. The multivariable-adjusted csHRs (95% confidence interval) of higher BMI categories (25–27.4 and ≥ 27.5 kg/m<sup>2</sup>) for obesity-related cancer mortality were 0.93 (0.78, 1.10) and 1.18 (0.92, 1.50) in men and 1.25 (1.04, 1.50) and 1.48 (1.19, 1.84) in women, respectively. The corresponding csHRs for CVD mortality were 1.27 (1.10, 1.46) and 1.59 (1.30, 1.95) in men and 1.10 (0.95, 1.28) and 1.44 (1.21, 1.72) in women, respectively. The PAF of a BMI ≥ 25 kg/m<sup>2</sup> for obesity-related cancer was −0.2% in men and 6.7% in women and that for CVD was 5.0% in men and 4.5% in women.</p><p><b>Conclusion:</b> A BMI ≥ 25 kg/m<sup>2</sup> is associated with an increased risk of obesity-related cancer in women and CVD in both sexes.</p>

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  77. Change in the Number of Patient Safety Reports Through a 16-Year Patient Safety Initiative: A Retrospective Study Focusing on the Incident Severity and Type in a Japanese Hospital. Reviewed International journal

    Daisuke Koike, Masahiro Ito, Akihiko Horiguchi, Hiroshi Yatsuya, Atsuhiko Ota

    Risk management and healthcare policy   Vol. 15   page: 2071 - 2081   2022

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    PURPOSE: To describe the long-term quantitative change in the number of submissions of patient safety reports after the introduction of a patient safety reporting system, focusing on incident severity and type. PATIENTS AND METHODS: This study was performed at a tertiary care hospital in Japan. Patient safety reports from 2006 to 2020 were retrospectively reviewed. Incident severity was classified from level 0 (near miss) to level 5 (fatality). The incident types included those related to medication, patient care, drains and catheters, procedures and interventions, examinations, medical devices, and blood transfusions. The study period was divided into 1. 2004-2007; 2. 2008-2014; and 3. 2015-2020 based on the implementation of hospital patient safety strategies. The number of reports per hospital worker was compared among the study periods and the incident levels and types. RESULTS: We analyzed 96,332 reports extracted from the patient safety reporting system of the hospital. The total number of reports per hospital worker has increased over time. The numbers of levels 0 and 1 incidents increased throughout the study period. In addition, levels 3a and 3b incidents increased between periods 2 and 3. All incident types, except for procedure and intervention-related incidents, increased between periods 1 and 2 and between periods 1 and 3. The number of procedure and intervention-related incidents increased between periods 2 and 3, although it did not between periods 1 and 2. CONCLUSION: We found increases in the number of patient safety reports according to the incident severity and type. This suggests two contextual changes occurring during the cultural maturity process, which reflected the development of organizational patient safety culture in our institution. The first was the establishment of a reporting attitude in the institution. The second was to overcome barriers to patient safety.

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  78. Prediction of Lifetime Risk of Cardiovascular Disease Deaths Stratified by Sex in the Japanese Population Reviewed International journal

    Yukiko Imai, Sachiko Mizuno Tanaka, Michihiro Satoh, Takumi Hirata, Yoshitaka Murakami, Katsuyuki Miura, Takashi Waki, Aya Hirata, Toshimi Sairenchi, Fujiko Irie, Mizuki Sata, Toshiharu Ninomiya, Takayoshi Ohkubo, Shizukiyo Ishikawa, Yoshihiro Miyamoto, Hirofumi Ohnishi, Shigeyuki Saitoh, Akiko Tamakoshi, Michiko Yamada, Masahiko Kiyama, Hiroyasu Iso, Kiyomi Sakata, Hideaki Nakagawa, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Akihiko Kitamura, Yutaka Kiyohara, Akiko Harada, Masaru Sakurai, Takeo Nakayama, Ichiro Tsuji, Yoshihiro Kokubo, Hiroshi Yatsuya, Tomonori Okamura

    Journal of the American Heart Association   Vol. 10 ( 23 )   2021.12

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    <sec xml:lang="en">
    <title>Background</title>
    <p xml:lang="en">Lifetime risk is an informative estimate for driving lifestyle and behavioral changes especially for young adults. The impact of composite risk factors for cardiovascular disease on lifetime risk stratified by sex has not been investigated in the Japanese population, which has a much lower mortality of coronary heart disease compared with the Western population. We aimed to estimate lifetime risk of death from cardiovascular disease attributable to traditional risk factors.


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    <p xml:lang="en">We analyzed pooled individual data from the Evidence for Cardiovascular Prevention from Observational Cohorts in a Japanese cohort study. A modified Kaplan–Meier approach was used to estimate the remaining lifetime risk of cardiovascular death. In total, 41 002 Japanese men and women with 537 126 person‐years of follow‐up were included. The lifetime risk at the index‐age of 45 years for those with optimal risk factors (total cholesterol &lt;4.65 mmol/L, systolic blood pressure &lt;120 mm Hg, diastolic blood pressure &lt;80 mm Hg, absence of diabetes, and absence of smoking habit) was lower compared with the highest risk profile of ≥2 risk factors (6.8% [95% CI, 0%–11.9%] versus 19.4% [16.7%–21.4%] for men and 6.9% [1.2%–11.5%] versus 15.4% [12.6%–18.1%] for women).


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    <title>Conclusions</title>
    <p xml:lang="en">The magnitude and the number of risk factors were progressively associated with increased lifetime risk even in individuals in early adulthood who tend to have low short‐term risk. The degree of established cardiovascular risk factors can be converted into lifetime risk. Our findings may be useful for risk communication in the early detection of future cardiovascular disease risk.


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  79. Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study. Reviewed International journal

    Atsuhiko Ota, Yuanying Li, Hiroshi Yatsuya, Kozo Tanno, Kiyomi Sakata, Kazumasa Yamagishi, Hiroyasu Iso, Nobufumi Yasuda, Isao Saito, Tadahiro Kato, Kazuhiko Arima, Yoko Sou, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Manami Inoue, Motoki Iwasaki, Norie Sawada, Shoichiro Tsugane

    Journal of cancer survivorship : research and practice   Vol. 15 ( 6 ) page: 912 - 921   2021.12

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    PURPOSE: This study compared working cancer survivors' self-rated health status (SRHS), physical functional capacity, depressive symptoms, and happiness to those of cancer-free workers. METHODS: A nationwide general population-based cross-sectional study on a sample of Japanese was conducted. Prevalence of deteriorated SRHS, restricted physical functional capacity, depressive symptoms, and perceived happiness were compared between working cancer survivors and cancer-free workers with multivariable logistic regression analysis adjusted for age and sociodemographic and health-related backgrounds. RESULTS: Of the 28,311 male and 26,068 female workers, 977 (3.5%) and 1267 (4.9%) were cancer survivors, respectively. Working cancer survivors reported deteriorated SRHS more frequently than cancer-free workers: 21.3% vs. 13.8%, multivariable-adjusted odds ratio (95% confidence interval), 1.64 (1.39-1.95) for men, 23.8% vs. 17.5%, 1.34 (1.16-1.54) for women. Restricted physical functional capacity was reported more frequently in working cancer survivors than cancer-free workers: 6.8% vs. 2.6%, 1.76 (1.34-2.32) for men, 4.9% vs. 2.0%, 2.06 (1.56-2.71) for women. No significant difference was found for depressive symptoms: 21.6% vs. 22.9% in men, 30.0% vs. 28.5% in women. Working cancer survivors felt happiness more frequently than cancer-free survivors in men (77.3% vs. 71.7%, 1.21 (1.01-1.45)) but not in women (76.1% vs. 74.9%). CONCLUSIONS: Working cancer survivors had worse SRHS and more restricted physical functional capacity than cancer-free workers. In men, working cancer survivors felt happiness more frequently than cancer-free workers. IMPLICATIONS FOR CANCER SURVIVORS: Continuous support to improve cancer survivors' SRHS and physical functional capacity would be necessary even while they are working.

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  80. The association of work-related stress according to the demand-control model with aggravation of pre-existing disease during the first state of COVID-19 emergency in Japan. Reviewed

    Yupeng He, Hiroshi Yatsuya, Chifa Chiang, Atsuhiko Ota, Ryo Okubo, Tomohiro Ishimaru, Takahiro Tabuchi

    Journal of epidemiology   Vol. 31 ( 12 ) page: 635 - 640   2021.12

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    BACKGROUND: The job environment has changed a lot during the period of coronavirus disease 2019 (COVID-19) pandemic. This study aimed to investigate the association between work-related stress and aggravation of pre-existing disease in workers during the first state of COVID-19 emergency in Japan. METHODS: Data were obtained from a large internet survey conducted between August 25 and September 30, 2020 in Japan. Participants who reported that they had a job as well as current history of disease(s) (i.e., pre-existing conditions) were included (n=3090). Aggravation of pre-existing disease during the state of emergency was self-reported. Work-related stress from April 2020 (since the state of COVID-19 emergency) was assessed according to job demand-control model. Multivariable logistic regression models were used to analyze the association. RESULTS: Aggravation of pre-existing diseases was reported by 334 participants (11%). The numbers of participants with high demand and low control were 112 (18%) and 100 (14%), respectively. Compared to medium demand, high demand was significantly associated with aggravation of pre-existing diseases (odds ratio: 1.77, 95% confidence interval: 1.30-2.42). Low control compared to medium control was significantly associated with aggravation of pre-existing diseases (odds ratio: 1.39, 95% confidence interval: 1.02-1.92). CONCLUSION: Work-related stress during the first state of COVID-19 emergency was associated with aggravation of pre-existing disease during that period.

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  81. Seasonal variation in submacular hemorrhages in retinal macroaneurysms and its disappearance in age-related macular degeneration Reviewed

    Hiroki Kaneko, Noriko Takashi, Masaaki Matsunaga, Yasuki Ito, Jun Takeuchi, Hiroko Terasaki, Hiroshi Yatsuya, Koji M. Nishiguchi

    Graefe's Archive for Clinical and Experimental Ophthalmology   Vol. 259 ( 12 ) page: 3589 - 3596   2021.12

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    Purpose: To investigate whether previously reported seasonal variation and winter-dominant prevalence of acute massive submacular hemorrhages (SMHs) caused by age-related macular degeneration (AMD) disappeared, and those caused by retinal microaneurysms (RMAs) emerged. Method: The medical charts of 95 patients (95 eyes) with SMH caused by AMD and 76 patients (76 eyes) with SMH caused by RMAs in 2012–2019 were retrospectively reviewed. For each subject, the month of onset, the mean ambient temperature of that month were recorded. Results: The monthly numbers of cases of SMHs caused by AMD from January to December were 6, 8, 4, 9, 7, 10, 9, 11, 7, 11, 3, and 10. No significant seasonal variation in the monthly incidence was identified (Roger’s R = 1.89, p = 0.39). The monthly numbers of SMHs caused by RMAs from January to December were 3, 11, 11, 8, 7, 8, 5, 5, 2, 4, 7, and 5. There was significant seasonal variation in the monthly incidence (Roger’s R = 7.67, p = 0.02). There was no significant correlation between the monthly incidence of SMHs caused by RMAs and mean ambient temperature. Conclusion: Our previous study conducted for cases obtained in 1998–2005 showed seasonal cyclic trend in the number of SMHs caused by AMD, with the peak in winter. However, that significant seasonal variation disappeared in 2012–2019 in the present study. Common usage of OCT devices and anti-VEGF drugs might be the reason for the lack of seasonal variation in the cases of SMH caused by AMD. [Figure not available: see fulltext.]

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  82. Peanut Consumption and Risk of Stroke and Ischemic Heart Disease in Japanese Men and Women: The JPHC Study. Reviewed International journal

    Satoyo Ikehara, Hiroyasu Iso, Yoshihiro Kokubo, Kazumasa Yamagishi, Isao Saito, Hiroshi Yatsuya, Takashi Kimura, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane

    Stroke   Vol. 52 ( 11 ) page: 3543 - 3550   2021.11

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    BACKGROUND AND PURPOSE: Several prospective cohort studies and a randomized clinical trial have shown the beneficial effects of peanut consumption on cardiovascular disease and its risk factors. We examined the association between peanut consumption and risk of cardiovascular disease in Japanese men and women. METHODS: We analyzed data of 74 793 participants aged 45 to 74 years who completed a lifestyle questionnaire including the validated food frequency questionnaire in the Japan Public Health Center-based Prospective Study. They were followed up from 1995 to 2009 for cohort I and from 1998 to 1999 to 2012 for cohort II. Peanut consumption was calculated from the food frequency questionnaire, and the end points were incidence of stroke, ischemic heart disease, and cardiovascular disease (stroke and ischemic heart disease). RESULTS: During a median follow-up of 14.8 years, 3,599 strokes and 849 ischemic heart diseases were reported. Higher peanut consumption was associated with reduced risks of total stroke, ischemic stroke, and cardiovascular disease among men and women. The multivariable hazard ratios (95% CIs) for the highest versus lowest quartiles of peanut consumption after adjustment for age, sex, public health center, smoking, alcohol consumption, perceived stress level, physical activity, vegetable, fruit, fish, soy, sodium and total energy intakes, body mass index, history of hypertension, history of diabetes, and cholesterol-lowering drug were 0.84 (0.77-0.93, P for trend=0.002) for total stroke, 0.80 (0.71-0.90, P for trend=0.002) for ischemic stroke, 0.93 (0.79-1.08, P for trend=0.27) for hemorrhagic stroke, 0.97 (0.80-1.17, P for trend=0.81) for ischemic heart disease and 0.87 (0.80-0.94, P for trend=0.004) for cardiovascular disease, and these associations were similarly observed in both sexes. CONCLUSIONS: Higher peanut consumption was associated with reduced risk of stroke, especially ischemic stroke, but not ischemic heart disease in Japanese men and women.

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  83. Having hobbies and the risk of cardiovascular disease incidence: A Japan public health center-based study. Reviewed International journal

    Xiaowen Wang, Jia-Yi Dong, Kokoro Shirai, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada

    Atherosclerosis   Vol. 335   page: 1 - 7   2021.10

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    BACKGROUND AND AIMS: The role of hobbies as a protective factor against cardiovascular diseases (CVD) has gained increasing attention; however, no large-scale studies were performed to confirm this. We aimed to examine the association between having hobbies and the risk of total CVD, coronary heart disease (CHD), and stroke in a large Japanese cohort. METHODS: A total of 56,381 adults aged 45-74 years were divided into the non-hobby, having a hobby, and having many hobbies groups. We performed Cox proportional hazard models to estimate the hazard ratio (HRs) for incident CVD, CHD, and stroke after adjusting for potential confounding factors. RESULTS: We identified 3685 incident CVDs (940 CHDs and 2839 strokes) during a median follow-up of 16.3 years. After multivariable adjustment, compared to the non-hobby group, participants having a hobby and many hobbies had a 10% (HR = 0.90 [0.83, 0.97]) and 20% (HR = 0.80 [0.69, 0.93]) lower risk of CVD incidence, respectively. The risk of CHD was lower in those with many hobbies, but the association between having many hobbies and CHD risk was not statistically significant. We also found a similar inverse association for stroke. Compared to the non-hobby group, participants having a hobby and many hobbies had a 13% (HR = 0.87 [0.80, 0.96]) and 20% (HR = 0.80 [0.68, 0.94]) lower risk of stroke. CONCLUSIONS: Having hobbies was associated with a lower risk of CVD. Engagement in hobbies may emerge as an important target for healthy lifestyle promotion for the primary prevention of CVD.

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  84. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019 Reviewed International coauthorship

    Feigin, VL; Stark, BA; Johnson, CO; Roth, GA; Bisignano, C; Abady, GG; Abbasifard, M; Abbasi-Kangevari, M; Abd-Allah, F; Abedi, V; Abualhasan, A; Abu-Rmeileh, NM; Abushouk, AI; Adebayo, OM; Agarwal, G; Agasthi, P; Ahinkorah, BO; Ahmad, S; Ahmadi, S; Salih, YA; Aji, B; Akbarpour, S; Akinyemi, RO; Al Hamad, H; Alahdab, F; Alif, SM; Alipour, V; Aljunid, SM; Almustanyir, S; Al-Raddadi, RM; Salman, RAS; Alvis-Guzman, N; Ancuceanu, R; Anderlini, D; Anderson, JA; Ansar, A; Antonazzo, IC; Arabloo, J; Ärnlöv, J; Artanti, KD; Aryan, Z; Asgari, S; Ashraf, T; Athar, M; Atreya, A; Ausloos, M; Baig, AA; Baltatu, OC; Banach, M; Barboza, MA; Barker-Collo, SL; Bärnighausen, TW; Barone, MTU; Basu, S; Bazmandegan, G; Beghi, E; Beheshti, M; Béjot, Y; Bell, AW; Bennett, DA; Bensenor, IM; Bezabhe, WM; Bezabih, YM; Bhagavathula, AS; Bhardwaj, P; Bhattacharyya, K; Bijani, A; Bikbov, B; Birhanu, MM; Boloor, A; Bonny, A; Brauer, M; Brenner, H; Bryazka, D; Butt, ZA; dos Santos, FLC; Campos-Nonato, IR; Cantu-Brito, C; Carrero, JJ; Castañeda-Orjuela, CA; Catapano, AL; Chakraborty, PA; Charan, J; Choudhari, SG; Chowdhury, EK; Chu, DT; Chung, SC; Colozza, D; Costa, VM; Costanzo, S; Criqui, MH; Dadras, O; Dagnew, B; Dai, X; Dalal, K; Damasceno, AAM; D'Amico, E; Dandona, L; Dandona, R; Gela, JD; Davletov, K; De La Cruz-Góngora, V; Desai, R; Dhamnetiya, D; Dharmaratne, SD; Dhimal, ML; Dhimal, M; Diaz, D; Dichgans, M; Dokova, K; Doshi, R; Douiri, A; Duncan, BB; Eftekharzadeh, S; Ekholuenetale, M; El Nahas, N; Elgendy, IY; Elhadi, M; El-Jaafary, SI; Endres, M; Endries, AY; Erku, DA; Faraon, EJA; Farooque, U; Farzadfar, F; Feroze, AH; Filip, I; Fischer, F; Flood, D; Gad, MM; Gaidhane, S; Gheshlagh, RG; Ghashghaee, A; Ghith, N; Ghozali, G; Ghozy, S; Gialluisi, A; Giampaoli, S; Gilani, SA; Gill, PS; Gnedovskaya, EV; Golechha, M; Goulart, AC; Guo, YM; Gupta, R; Gupta, VB; Gupta, VK; Gyanwali, P; Hafezi-Nejad, N; Hamidi, S; Hanif, A; Hankey, GJ; Hargono, A; Hashi, A; Hassan, TS; Hassen, HY; Havmoeller, RJ; Hay, SI; Hayat, K; Hegazy, MI; Herteliu, C; Holla, R; Hostiuc, S; Househ, M; Huang, J; Humayun, A; Hwang, BF; Iacoviello, L; Iavicoli, I; Ibitoye, SE; Ilesanmi, OS; Ilic, IM; Ilic, MD; Iqbal, U; Irvani, SSN; Islam, SMS; Ismail, NE; Iso, H; Isola, G; Iwagami, M; Jacob, L; Jain, V; Jang, SI; Jayapal, SK; Jayaram, S; Jayawardena, R; Jeemon, P; Jha, RP; Johnson, WD; Jonas, JB; Joseph, N; Jozwiak, JJ; Jürisson, M; Kalani, R; Kalhor, R; Kalkonde, Y; Kamath, A; Kamiab, Z; Kanchan, T; Kandel, H; Karch, A; Katoto, PDMC; Kayode, GA; Keshavarz, P; Khader, YS; Khan, EA; Khan, IA; Khan, M; Khan, MAB; Khatib, MN; Khubchandani, J; Kim, GR; Kim, MS; Kim, YJ; Kisa, A; Kisa, S; Kivimäki, M; Kolte, D; Koolivand, A; Laxminarayana, SLK; Koyanagi, A; Krishan, K; Krishnamoorthy, V; Krishnamurthi, RV; Kumar, GA; Kusuma, D; La Vecchia, C; Lacey, B; Lak, HM; Lallukka, T; Lasrado, S; Lavados, PM; Leonardi, M; Li, BY; Li, SS; Lin, HL; Lin, RT; Liu, XF; Lo, WD; Lorkowski, S; Lucchetti, G; Saute, RL; Razek, HMA; Magnani, FG; Mahajan, PB; Majeed, A; Makki, A; Malekzadeh, R; Malik, AA; Manafi, N; Mansournia, MA; Mantovani, LG; Martini, S; Mazzaglia, G; Mehndiratta, MM; Menezes, RG; Meretoja, A; Mersha, AG; Jonasson, JM; Miazgowski, B; Miazgowski, T; Michalek, IM; Mirrakhimov, EM; Mohammad, Y; Mohammadian-Hafshejani, A; Mohammed, S; Mokdad, AH; Mokhayeri, Y; Molokhia, M; Moni, MA; Al Montasir, A; Moradzadeh, R; Morawska, L; Morze, J; Muruet, W; Musa, KI; Nagarajan, AJ; Naghavi, M; Swamy, SN; Nascimento, BR; Negoi, RI; Kandel, SN; Nguyen, TH; Norrving, B; Noubiap, JJ; Nwatah, VE; Oancea, B; Odukoya, OO; Olagunju, AT; Orru, H; Owolabi, MO; Padubidri, JR; Pana, A; Parekh, T; Park, EC; Kan, FP; Pathak, M; Peres, MFP; Perianayagam, A; Pham, TM; Piradov, MA; Podder, V; Polinder, S; Postma, MJ; Pourshams, A; Radfar, A; Rafiei, A; Raggi, A; Rahim, F; Rahimi-Movaghar, V; Rahman, M; Rahman, MA; Rahmani, AM; Rajai, N; Ranasinghe, P; Rao, CR; Rao, SJ; Rathi, P; Rawaf, DL; Rawaf, S; Reitsma, MB; Renjith, V; Renzaho, AMN; Rezapour, A; Rodriguez, JAB; Roever, L; Romoli, M; Rynkiewicz, A; Sacco, S; Sadeghi, M; Moghaddam, SS; Sahebkar, A; Saif-Ur-Rahman, K; Salah, R; Samaei, M; Samy, AM; Santos, IS; Santric-Milicevic, MM; Sarrafzadegan, N; Sathian, B; Sattin, D; Schiavolin, S; Schlaich, MP; Schmidt, MI; Schutte, AE; Sepanlou, SG; Seylani, A; Sha, F; Shahabi, S; Shaikh, MA; Shannawaz, M; Shawon, MSR; Sheikh, A; Sheikhbahaei, S; Shibuya, K; Siabani, S; Silva, DAS; Singh, JA; Singh, JK; Skryabin, VY; Skryabina, AA; Sobaih, BH; Stortecky, S; Stranges, S; Tadesse, EG; Tarigan, IU; Temsah, MH; Teuschl, Y; Thrift, AG; Tonelli, M; Tovani-Palone, MR; Tran, BX; Tripathi, M; Tsegaye, GW; Ullah, A; Unim, B; Unnikrishnan, B; Vakilian, A; Tahbaz, SV; Vasankari, TJ; Venketasubramanian, N; Vervoort, D; Vo, B; Volovici, V; Vosoughi, K; Vu, GT; Vu, LG; Wafa, HA; Waheed, Y; Wang, YZ; Wijeratne, T; Winkler, AS; Wolfe, CDA; Woodward, M; Wu, JH; Hanson, SW; Xu, XY; Yadav, L; Yadollahpour, A; Jabbari, SHY; Yamagishi, K; Yatsuya, H; Yonemoto, N; Yu, CH; Yunusa, I; Zaman, MS; Bin Zaman, S; Zamanian, M; Zand, R; Zandifar, A; Zastrozhin, MS; Zastrozhina, A; Zhang, Y; Zhang, ZJ; Zhong, C; Zuniga, YMH; Murray, CJL

    LANCET NEUROLOGY   Vol. 20 ( 10 ) page: 795 - 820   2021.10

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    Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.

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  85. アポリポ蛋白A2のアイソフォームと心筋梗塞発症との関連に関するコホート内症例対照研究 多目的コホート(JPHC)研究

    木原 朋未, 山岸 良匡, 本田 一文, 池田 愛, 八谷 寛, 斉藤 功, 小久保 喜弘, 山地 太樹, 島津 太一, 澤田 典絵, 岩崎 基, 磯 博康, 津金 昌一郎

    日本動脈硬化学会総会プログラム・抄録集   Vol. 53回   page: 232 - 232   2021.10

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  86. Association of anthropometric indices of obesity with hypertension among public employees in northern Ethiopia: Findings from a cross-sectional survey Reviewed International coauthorship

    K. M. Saif-Ur-Rahman, Chifa Chiang, Lemlem Weldegerima Gebremariam, Esayas Haregot Hilawe, Yoshihisa Hirakawa, Atsuko Aoyama, Hiroshi Yatsuya

    BMJ Open   Vol. 11 ( 9 ) page: e050969   2021.9

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    Objectives: The burden of hypertension is increasing in low-income countries, including Ethiopia. Obesity is widely known to be associated with hypertension, but different anthropometric indices of obesity might differ in association with hypertension, which is largely unknown in northern Ethiopia. Design: Data from our previous cross-sectional epidemiological survey were statistically analysed. Setting: Public employees in the regional capital city in northern Ethiopia. Participants: The data of 1380 participants (823 men and 557 non-pregnant women) aged 25 and 64 years were analysed. Outcome measures: The presence of hypertension was the outcome measure and multivariable-adjusted logistic regression analyses were used to investigate the association of body mass index (BMI), waist circumference, and waist-hip ratio in men and women separately. The area under the curve (AUC) for three anthropometric indices for discriminating hypertension was also obtained. Separate analyses were conducted for waist circumference and waist-hip ratio analyses further adjusted for BMI. Results: BMI was linearly associated with hypertension in men (OR for 1 SD increase in BMI 1.45, p=0.001) and women (OR for 1 SD increase in BMI 1.41, p=0.01). The association of waist circumference was independent of BMI both in men (OR for 1 SD increase in waist circumference: 1.74, p=0.002) and women (OR for 1 SD increase in waist circumference: 1.57, p=0.029). The association of waist-hip ratio with hypertension adjusted for BMI was significant in men (OR for 1 SD increase in the waist-hip ratio: 1.46, p&lt
    0.001), but was weak and non-significant in women. The AUC for BMI was 0.64 in men and 0.67 in women, while AUC for waist circumference was 0.69 both in men and women. Conclusions: Waist circumference was associated with hypertension independent of BMI among public employees in northern Ethiopia.

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  87. Associations of insomnia with noise annoyance and neighborhood environments: A nationwide cross-sectional study in Japan. Reviewed International journal

    Tomoya Hanibuchi, Tomoki Nakaya, Tsuyoshi Kitajima, Hiroshi Yatsuya

    Preventive medicine reports   Vol. 23   page: 101416 - 101416   2021.9

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    Despite the increasing knowledge on the association between neighborhood and health, few studies have investigated sleep disorders in Japan, particularly the impact of neighborhood noise on sleep. Thus, this study aimed to investigate the associations between insomnia symptoms and annoyance because of traffic and neighborhood noise in Japan, which has different neighborhood conditions compared with those of the western societies. Neighborhood built and socioeconomic environments roles were also examined. We used nationwide cross-sectional data collected through a 2015 online survey of Japanese adults aged 20-64 years (n = 4,243). Adjusted prevalence ratios for insomnia according to the exposures were estimated using the multilevel Poisson regression models. The results showed that having insomnia was significantly associated with experiencing neighborhood and traffic-noise annoyance. Neighborhood noise had a stronger and independent association with insomnia. However, the neighborhood environmental variables, including population density, deprivation index, and access to commercial areas, were not associated with insomnia. In conclusion, noise annoyance, particularly that sourced from neighbors, is an important factor in relation to sleep health. Health and urban-planning policymakers should consider neighborhood noise, in addition to traffic noise, as health-related issues in residential neighborhoods.

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  88. Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study

    Murai, U; Yamagishi, K; Sata, M; Kokubo, Y; Saito, I; Yatsuya, H; Ishihara, J; Inoue, M; Sawada, N; Iso, H; Tsugane, S

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY   Vol. 50   2021.9

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  89. The association of work-related stress with aggravation of pre-existing disease during COVID-19 emergency in Japan

    He, YP; Yatsuya, H; Chiang, C; Ota, A; Okubo, R; Ishimaru, T; Tabuchi, T

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY   Vol. 50   2021.9

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    DOI: 10.1093/ije/dyab168.273

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  90. 小学2年非肥満児における男女別の推定食塩摂取量、尿中Na/K比と収縮期血圧の関連

    金子 佳世, 伊藤 由起, 加藤 沙耶香, 玉田 葉月, 松木 太郎, 榎原 毅, 井上 貴子, 杉浦 真弓, 齋藤 伸治, 八谷 寛, 藤田 直也, 上島 通浩

    東海公衆衛生雑誌   Vol. 9 ( 1 ) page: 49 - 49   2021.7

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  91. Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019 Reviewed International coauthorship International journal

    Reitsma, MB; Reitsma, MB; Kendrick, PJ; Ababneh, E; Abbafati, C; Abbasi-Kangevari, M; Abdoli, A; Abedi, A; Abhilash, ES; Abila, DB; Aboyans, V; Abu-Rmeileh, NME; Adebayo, OM; Advani, SM; Aghaali, M; Ahinkorah, BO; Ahmad, S; Ahmadi, K; Ahmed, H; Aji, B; Akunna, CJ; Al-Aly, Z; Alanzi, TM; Alhabib, KF; Ali, L; Alif, SM; Alipour, V; Aljunid, SM; Alla, F; Allebeck, P; Alvis-Guzman, N; Amin, TT; Amini, S; Amu, H; Amul, GGH; Ancuceanu, R; Anderson, JA; Ansari-Moghaddam, A; Antonio, CAT; Antony, B; Anvari, D; Arabloo, J; Arian, ND; Arora, M; Asaad, M; Ausloos, M; Awan, AT; Ayano, G; Aynalem, GL; Azari, S; Darshan, BB; Badiye, AD; Baig, AA; Bakhshaei, MH; Banach, M; Banik, PC; Barker-Collo, SL; Bärnighausen, TW; Barqawi, HJ; Basu, S; Bayati, M; Bazargan-Hejazi, S; Behzadifar, M; Bekuma, TT; Bennett, DA; Bensenor, IM; Berfield, KSS; Bhagavathula, AS; Bhardwaj, N; Bhardwaj, P; Bhattacharyya, K; Bibi, S; Bijani, A; Bintoro, BS; Biondi, A; Birara, S; Braithwaite, D; Brenner, H; Brunoni, AR; Burkart, K; Butt, ZA; dos Santos, FLC; Cámera, LA; Car, J; Cárdenas, R; Carreras, G; Carrero, JJ; Castaldelli-Maia, JM; Cattaruzza, MSS; Chang, JC; Chen, SM; Chu, DT; Chung, SC; Cirillo, M; Costa, VM; Couto, RAS; Dadras, O; Dai, XC; Damasceno, AAM; Damiani, G; Dandona, L; Dandona, R; Daneshpajouhnejad, P; Gela, JD; Davletov, K; Molla, MD; Dessie, GA; Desta, AA; Dharmaratne, SD; Dianatinasab, M; Diaz, D; Do, HT; Douiri, A; Duncan, BB; Duraes, AR; Eagan, AW; Kalan, ME; Edvardsson, K; Elbarazi, I; El Tantawi, M; Esmaeilnejad, S; Fadhil, I; Faraon, EJA; Farinha, CSES; Farwati, M; Farzadfar, F; Fazlzadeh, M; Feigin, VL; Feldman, R; Prendes, CF; Ferrara, P; Filip, I; Filippidis, F; Fischer, F; Flor, LS; Foigt, NA; Folayan, MO; Foroutan, M; Gad, MM; Gaidhane, AM; Gallus, S; Geberemariyam, BS; Ghafourifard, M; Ghajar, A; Ghashghaee, A; Giampaoli, S; Gill, PS; Glozah, FN; Gnedovskaya, EV; Golechha, M; Gopalani, SV; Gorini, G; Goudarzi, H; Goulart, AC; Greaves, F; Guha, A; Guo, YM; Gupta, B; Das Gupta, R; Gupta, R; Gupta, T; Gupta, V; Hafezi-Nejad, N; Haider, MR; Hamadeh, RR; Hankey, GJ; Hargono, A; Hartono, RK; Hassankhani, H; Hay, SI; Heidari, G; Herteliu, C; Hezam, K; Hird, TR; Hole, MK; Holla, R; Hosseinzadeh, M; Hostiuc, S; Househ, M; Hsiao, T; Huang, JJ; Iannucci, VC; Ibitoye, SE; Idrisov, B; Ilesanmi, OS; Ilic, IM; Ilic, MD; Inbaraj, LR; Irvani, SSN; Islam, JY; Islam, RM; Islam, SMS; Islami, F; Iso, H; Itumalla, R; Iwagami, M; Jaafari, J; Jain, V; Jakovljevic, M; Jang, SI; Janjani, H; Jayaram, S; Jeemon, P; Jha, RP; Jonas, JB; Joo, T; Jürisson, M; Kabir, A; Kabir, Z; Kalankesh, LR; Kanchan, T; Kandel, H; Kapoor, N; Karimi, SE; Katikireddi, SV; Kebede, HK; Kelkay, B; Kennedy, RD; Khoja, AT; Khubchandani, J; Kim, GR; Kim, YE; Kimokoti, RW; Kivimäki, M; Kosen, S; Laxminarayana, SLK; Koyanagi, A; Krishan, K; Kugbey, N; Kumar, GA; Kumar, N; Kurmi, OP; Kusuma, D; Lacey, B; Lam, JO; Landires, I; Lasrado, S; Lauriola, P; Lee, DW; Lee, YH; Leung, JN; Li, SS; Lin, HL; Linn, S; Liu, W; Lopez, AD; Lopukhov, PD; Lorkowski, S; Lugo, A; Majeed, A; Maleki, A; Malekzadeh, R; Malta, DC; Mamun, AA; Manjunatha, N; Mansouri, B; Mansournia, MA; Martinez-Raga, J; Martini, S; Mathur, MR; Medina-Solís, CE; Mehata, S; Mendoza, W; Menezes, RG; Meretoja, A; Meretoja, TJ; Miazgowski, B; Michalek, IM; Miller, TR; Mirrakhimov, EM; Mirzaei, H; Mirzaei-Alavijeh, M; Misra, S; Moghadaszadeh, M; Mohammad, Y; Mohammadian-Hafshejani, A; Mohammed, S; Mokdad, AH; Monasta, L; Moni, MA; Moradi, G; Moradi-Lakeh, M; Moradzadeh, R; Morrison, SD; Mossie, TB; Mubarik, S; Mullany, EC; Murray, CJL; Naghavi, M; Naghshtabrizi, B; Nair, S; Nalini, M; Nangia, V; Naqvi, AA; Swamy, SN; Naveed, M; Nayak, S; Nayak, VC; Nazari, J; Nduaguba, SO; Kandel, SN; Nguyen, CT; Nguyen, HLT; Nguyen, SH; Nguyen, TH; Nixon, MR; Nnaji, CA; Norrving, B; Noubiap, JJ; Nowak, C; Ogbo, FA; Oguntade, AS; Oh, IH; Olagunju, AT; Oren, E; Otstavnov, N; Otstavnov, SS; Owolabi, MO; Pakhale, MPAS; Pakshir, K; Palladino, R; Pana, A; Panda-Jonas, S; Pandey, A; Parekh, U; Park, EC; Park, EK; Kan, FP; Patton, GC; Pawar, S; Pestell, RG; Pinheiro, M; Piradov, MA; Pirouzpanah, S; Pokhrel, KN; Polibin, RV; Prashant, A; Pribadi, DRA; Radfar, A; Rahimi-Movaghar, V; Rahman, A; Rahman, MHU; Rahman, MA; Rahmani, AM; Rajai, N; Ram, P; Ranabhat, CL; Rathi, P; Rawal, L; Renzaho, AMN; Reynales-Shigematsu, LM; Rezapour, A; Riahi, SM; Riaz, MA; Roever, L; Ronfani, L; Roshandel, G; Roy, A; Roy, B; Sacco, S; Saddik, B; Sahebkar, A; Salehi, S; Salimzadeh, H; Samaei, M; Samy, AM; Santos, IS; Santric-Milicevic, MM; Sarrafzadegan, N; Sathian, B; Sawhney, M; Saylan, M; Schaub, MP; Schmidt, MI; Schneider, IJC; Schutte, AE; Schwendicke, F; Seidu, AA; Kumar, NS; Sepanlou, SG; Seylani, A; Shafaat, O; Shah, SM; Shaikh, MA; Shalash, AS; Shannawaz, M; Sharafi, K; Sheikh, A; Sheikhbahaei, S; Shigematsu, M; Shiri, R; Shishani, K; Shivakumar, KM; Shivalli, S; Shrestha, R; Siabani, S; Sidemo, NB; Sigfusdottir, ID; Sigurvinsdottir, R; Silva, DAS; Silva, JP; Singh, A; Singh, JA; Singh, V; Sinha, DN; Sitas, F; Skryabin, VY; Skryabina, AA; Soboka, M; Soriano, JB; Soroush, A; Soshnikov, S; Soyiri, IN; Spurlock, EE; Sreeramareddy, CT; Stein, DJ; Steiropoulos, P; Stortecky, S; Straif, K; Abdulkader, RS; Sulo, G; Sundström, J; Tabuchi, T; Tadakamadla, SK; Taddele, BW; Tadesse, EG; Tamiru, AT; Tareke, M; Tareque, MI; Tarigan, IU; Temsah, MH; Thankappan, KR; Thapar, R; Tichopad, A; Tolani, MA; Topouzis, F; Tovani-Palone, MR; Tran, BX; Tripathy, JP; Tsegaye, GW; Tsilimparis, N; Tymeson, HD; Ullah, A; Ullah, S; Unim, B; Updike, RL; Vacante, M; Valdez, PR; Vardavas, C; Pérez, PV; Vasankari, TJ; Venketasubramanian, N; Verma, M; Vetrova, MV; Vo, B; Vu, GT; Waheed, Y; Wang, YZ; Welding, K; Werdecker, A; Whisnant, JL; Wickramasinghe, ND; Yamagishi, K; Yandrapalli, S; Yatsuya, H; Yazdi-Feyzabadi, V; Yeshaw, Y; Yimmer, MZ; Yonemoto, N; Yu, CH; Yunusa, I; Yusefzadeh, H; Moghadam, TZ; Zaman, MS; Zamanian, M; Zandian, H; Zar, HJ; Zastrozhin, MS; Zastrozhina, A; Zavala-Arciniega, L; Zhang, JR; Zhang, ZJ; Zhong, CW; Zuniga, YMH; Gakidou, E

    LANCET   Vol. 397 ( 10292 ) page: 2337 - 2360   2021.6

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    Background: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings: Globally in 2019, 1·14 billion (95% uncertainty interval 1·13–1·16) individuals were current smokers, who consumed 7·41 trillion (7·11–7·74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. Globally in 2019, smoking tobacco use accounted for 7·69 million (7·16–8·20) deaths and 200 million (185–214) disability-adjusted life-years, and was the leading risk factor for death among males (20·2% [19·3–21·1] of male deaths). 6·68 million [86·9%] of 7·69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation: In the absence of intervention, the annual toll of 7·69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a clear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Funding: Bloomberg Philanthropies and the Bill & Melinda Gates Foundation.

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  92. What constitutes healthiness of Washoku or Japanese diet? Invited International journal

    Hiroshi Yatsuya, Shoichiro Tsugane

    European Journal of Clinical Nutrition   Vol. 75 ( 6 ) page: 863 - 864   2021.6

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  93. Predictive risk factors for pneumothorax after transbronchial biopsy using endobronchial ultrasonography with a guide sheath. Reviewed International journal

    Yusuke Gotoh, Teppei Yamaguchi, Hiroshi Yatsuya, Aki Ikeda, Takuya Okamura, Yosuke Sakakibara, Takuma Ina, Yuri Maeda, Mariko Hirochi, Hisashi Kako, Yasuhiro Goto, Sumito Isogai, Naoki Yamamoto, Masashi Kondo, Kazuyoshi Imaizumi

    BMC pulmonary medicine   Vol. 21 ( 1 ) page: 181 - 181   2021.5

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    BACKGROUND: Pneumothorax is one complication of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS-TBB). We sought to clarify the risk factors for pneumothorax after EBUS-GS-TBB under fluoroscopic guidance. METHODS: We retrospectively reviewed data from 916 patients who underwent EBUS-GS-TBB at Fujita Health University Hospital. We evaluated the following risk factors for pneumothorax after EBUS-GS-TBB: patient characteristics (sex, age, and pulmonary comorbidities); lesion data (location, size, existence of ground-glass opacities [GGOs], pleural involvement, computed tomography [CT] bronchus sign, visibility on fluoroscopy, and EBUS findings); final diagnosis; years of bronchoscopist experience; and guide sheath size. Univariate and multivariate logistic regression analyses were performed. RESULTS: Among the 916 patients, 30 (3.28%) presented with pneumothorax. With a univariate analysis, factors that independently predisposed to pneumothorax included lesions containing GGOs, lesions in sagittal lung segments on fluoroscopy, lesions that were not visible on fluoroscopy, and infectious lesions. A univariate analysis also showed that lesions in the right upper lobe or left upper division, as well as malignant lesions, were less likely to lead to pneumothorax. Age, underlying pulmonary disease, CT bronchus sign, EBUS findings, bronchoscopist experience, and guide sheath size did not influence the incidence of pneumothorax. A multivariate analysis revealed that only lesions containing GGOs (odds ratio [OR] 6.47; 95% confidence interval [CI] 2.13-19.6, P = 0.001) and lesions in lung segments with a sagittal orientation on fluoroscopy (OR 2.47; 95% CI 1.09-5.58, P = 0.029) were significant risk factors for EBUS-GS-TBB-related pneumothorax. CONCLUSIONS: EBUS-GS-TBB of lesions containing GGOs or lesions located in sagittal lung segments on fluoroscopy correlate with a higher pneumothorax risk.

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  94. Prevalence of and factors associated with dilated choroidal vessels beneath the retinal pigment epithelium among the Japanese Reviewed

    Ito, Y; Ito, M; Iwase, T; Kataoka, K; Yamada, K; Yasuda, S; Ito, H; Takeuchi, J; Nakano, Y; Fujita, A; Horiguchi, E; Taki, Y; Yatsuya, H; Terasaki, H

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 11278   2021.5

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    Pachyvessels are pathologically dilated large choroidal vessels and are associated with the pathogenesis of several pachychoroid-related disorders, including central serous chorioretinopathy. We aimed to investigate the prevalence of and risk factors for pachyvessels in the Japanese population. We included 316 participants (aged ≥ 40 years) with normal right eyes. The presence of pachyvessels (vertical diameter > 300 µm, distance to the retinal pigment epithelium < 50 µm) was determined using 6 × 6 mm macular swept-source optical coherence tomography images, and associated risk factors were investigated. Subfoveal choroidal thickness was measured, and its associated risk factors investigated. The overall prevalence of pachychoroids was 9.5%. Regression analysis showed that a younger age, shorter axial length, male sex, and smoking were significantly associated with the presence of pachyvessels (p = 0.047; odds ratio [OR] 0.96 per year, p = 0.021; OR 0.61 per 1 mm, p = 0.012; OR 3.08 vs. female, and p = 0.011; OR 3.15 vs. non-smoker, respectively) and greater choroidal thickness (p < 0.001, p < 0.001, p < 0.003, and p < 0.017, respectively). The results were consistent with other research findings which showed that pachychoroid-related disorders such as central serous chorioretinopathy were associated with younger age, male sex, shorter axial length, and smoking. Smoking may be associated with choroidal circulatory disturbance in the Japanese population.

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  95. Inherited chromosomally integrated human herpesvirus 6 is a risk factor for spontaneous abortion. Reviewed International journal

    Hiroki Miura, Yoshiki Kawamura, Tamae Ohye, Fumihiko Hattori, Kei Kozawa, Masaru Ihira, Hiroshi Yatsuya, Haruki Nishizawa, Hiroki Kurahashi, Tetsushi Yoshikawa

    The Journal of infectious diseases   Vol. 223 ( 10 ) page: 1717 - 1723   2021.5

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    BACKGROUND: Human herpesvirus 6 (HHV-6) can be genetically transmitted from parent to child as inherited chromosomally integrated HHV-6 (iciHHV-6). HHV-6 reactivation occurs in pregnant women with iciHHV-6. We showed no gender differences in the frequency of index cases with iciHHV-6 but inheritance from the father was more common. We evaluated the association between iciHHV-6 status and spontaneous abortion. METHODS: iciHHV-6 was confirmed by high viral DNA copy numbers in whole blood and somatic cells. The origin of integrated viral genome, paternal or maternal, was examined using the same method. The pregnancy history of 23 mothers in families with iciHHV-6 and 285 mothers in families without iciHHV-6 was abstracted. RESULTS: Of 23 iciHHV-6 index cases, eight mothers and 15 fathers had iciHHV-6. Spontaneous abortion rates in mothers with and mothers without/fathers with iciHHV-6 and mothers in families without iciHHV-6 were 27.6%, 10.3%, and 14.8%, respectively (p = 0.012). Mother with iciHHV-6 (OR 6.41, 95%CI 1.10-37.4) and maternal age at the most recent pregnancy ≥40 years (OR 3.91, 95%CI 1.30-11.8) are associated with two or more spontaneous abortions. CONCLUSION: Mothers with iciHHV-6 is a risk factor for spontaneous abortion.

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  96. Perceptions and behaviors related to noncommunicable diseases in Palau: a qualitative study Reviewed

    Hiroko Shimizu, Yoshihisa Hirakawa, Chifa Chiang, Bernie Ngiralmau, Julita Tellei, Faustina K. Rehuher-Marugg, Takashi Mita, Hiroshi Yatsuya, Atsuko Aoyama

    Nagoya Journal of Medical Science   Vol. 83 ( 2 ) page: 287 - 298   2021.5

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    The increasing burden of noncommunicable diseases (NCDs) is a major public health concern in Palau. This study aims to identify social and psychological factors related to NCDs among Palauan people using a qualitative approach. We conducted eight key informant interviews and eight focus group discussions, which were audio-recorded, transcribed and translated into English. Ideas of the respondents were extracted and labeled, and the labels were analyzed using an inductive multistage approach referred to as qualitative content analysis. Three themes emerged: (1) home education, (2) traditional local community, and (3) modernization and westernization of lifestyle. Respondents believed that the influence of the family on lifestyle was significant, but that disciplining children at home had become difficult. They considered that the traditional lifestyle was mostly healthy, and were reluctant to abandon certain unhealthy customs, such as serving abundant food to guests as a sign of fraternity. They also thought that they overate because of their stressful modernized lifestyle. This is the first qualitative study to analyze perception and behavior of the Palauan people in relation to NCDs. We found that the increase in NCDs was related to two concurrent trends: preserving certain traditional customs unfavorable to good health, and abandoning time-consuming healthy traditional lifestyle to adopt a modernized one. We also found that Palauan people were not confident in their ability to prevent NCDs. Therefore, health promotion activities should be designed to empower people to make positive changes.

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  97. Weight change during middle age and risk of stroke and coronary heart disease: The Japan Public Health Center-based Prospective Study. Reviewed International journal

    Koichi Kisanuki, Isao Muraki, Kazumasa Yamagishi, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

    Atherosclerosis   Vol. 322   page: 67 - 73   2021.4

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    BACKGROUND AND AIMS: The impact of weight changes in middle age on the incidence of cardiovascular disease has not been well elucidated. We investigated whether a 5-year weight change was associated with risk of stroke and coronary heart disease (CHD) in middle-aged individuals. METHODS: We analyzed data of 74,928 participants aged 40-69 years who provided responses to the baseline and 5-year follow-up questionnaires in the Japan Public Health Center-based Prospective Study. Weight change was calculated by subtracting self-reported weight at baseline from that at 5-year follow-up. Stroke and CHD events were confirmed by reviewing hospital records. RESULTS: During 997,406 person-years of follow-up, we documented 3,975 stroke and 914 CHD events. The multivariable HRs of stroke for losing ≥5 kg compared to stable weight (change ≤2 kg) was 1.17 (95% CI, 1.01-1.37) in men versus 1.33 (1.13-1.57) for losing ≥5 kg and 1.61 (1.36-1.92) for gaining ≥5 kg in women (U-shaped association). These associations did not change after the exclusion of early events. The multivariable HR of CHD for gaining ≥5 kg was 1.22 (0.95-1.58) in men. After exclusion of early events within another 5 years, that positive association became stronger [multivariable HR 1.34 (1.00-1.82)]. CONCLUSIONS: Weight gain during middle age was associated with an increased risk of stroke in women and an increased risk of CHD in men. Weight loss was associated with an increased risk of stroke in both men and women.

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  98. Avoid clinical inertia: importance of asking and advising patients with diabetes who smoke about quitting. Reviewed

    Hiroshi Yatsuya

    Journal of diabetes investigation   Vol. 12 ( 3 ) page: 317 - 319   2021.3

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    The goal of diabetes care is to prevent complications and maximize quality of life of the patients. Evidence-based glycemic control is the centerpiece for achieving that goal. At the same time, more emphasis should also be put on managing other risk factors. A recent study published in Lancet Diabetes and Endocrinology confirmed that we should ask all the patients with diabetes whether they smoke, and if so, we should advise them to stop smoking immediately1 .

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  99. Factors Associated With Prediabetes and Diabetes Among Public Employees in Northern Ethiopia. Reviewed International coauthorship International journal

    Yupeng He, Chifa Chiang, Lemlem Weldegerima Gebremariam, Yoshihisa Hirakawa, Hiroshi Yatsuya, Atsuko Aoyama

    Asia-Pacific journal of public health   Vol. 33 ( 2-3 ) page: 242 - 250   2021.3

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    The increasing burden of diabetes mellitus is one of the major public health challenges in African countries, including Ethiopia. This is the first study aimed to identify factors associated with prediabetes and diabetes defined by both fasting blood glucose and glycated hemoglobin in Ethiopians. We analyzed data of a cross-sectional survey (1372 adults aged 25-64 years) conducted between October 2015 and February 2016; multinomial logistic regression models were applied. Abdominal obesity, total cholesterol, and non-high-density lipoprotein cholesterol were independently associated with prediabetes and diabetes in both sexes. Increased triglycerides and religious fasting practices were independently associated with prediabetes and diabetes only in men; hypertension was associated with prediabetes and diabetes only in women, while high-density lipoprotein cholesterol was not associated with prediabetes and diabetes in either sex. Sex differences in the association of triglycerides, hypertension, and dietary habit suggest that different approaches of lifestyle modification may be required for men and women.

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  100. Determinants of alcohol consumption and marijuana use among young adults in the Republic of Palau Reviewed International coauthorship

    Mizuki Sata, Renzhe Cui, Chifa Chiang, Singeru Travis Singeo, Berry Moon Watson, Hiroshi Yatsuya, Kaori Honjo, Takashi Mita, Everlynn Joy Temengil, Sherilynn Madraisau, Kazumasa Yamagishi, Atsuko Aoyama, Hiroyasu Iso

    Environmental Health and Preventive Medicine   Vol. 26 ( 1 ) page: 12   2021.1

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    <title>Abstract</title><sec>
    <title>Background</title>
    This study aimed to describe the status of alcohol consumption and drug use among young adults as well as their determinants.


    </sec><sec>
    <title>Methods</title>
    We conducted a cross-sectional study of 356 young adults (aged 18 to 24 years) living in Palau in 2013. The prevalence of self-reported alcohol and marijuana usage were compared within and between sexes, age groups, ethnicities, and education levels.


    </sec><sec>
    <title>Results</title>
    The proportion of current drinking was higher in people aged 21–24 than in those aged 18–20 (73.2% vs. 60.9%, <italic>p</italic> = 0.09 in men and 48.3% vs. 30.0%, <italic>p</italic> = 0.02 in women), while that of marijuana use did not differ between the age groups. The proportions of current drinking and marijuana use were higher in Palauan than in other ethnicities (current drinking: 70.6% vs. 40.6%, <italic>p</italic> = 0.005 in men and 38.8% vs. 16.6%, <italic>p</italic> = 0.04 in women; lifetime marijuana use: 80.0% vs. 52.9%, <italic>p</italic> = 0.02 in men and 56.1% vs. 30.6%, <italic>p</italic> = 0.09 in women). The proportion of frequent (3 times or more) marijuana users was higher for the lower educated than for the higher educated (62.5% vs. 32.1%, <italic>p</italic> &lt; 0.001 in men and 33.9% vs. 24.4%, <italic>p</italic> = 0.12 in women).


    </sec><sec>
    <title>Conclusions</title>
    Sex, age, ethnicity, and education were significant determinants of alcohol and marijuana use.


    </sec>

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  101. Health of university students under job and financial insecurity during COVID-19 pandemic Invited

    Hiroshi Yatsuya, Tatsuya Ishitake

    Journal of occupational health   Vol. 63 ( 1 ) page: e12223   2021.1

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  102. Work‐related factors among people with diabetes and the risk of cardiovascular diseases: A systematic review Reviewed International journal

    KM Saif‐Ur‐Rahman, Razib Mamun, Yuanying Li, Masaaki Matsunaga, Atsuhiko Ota, Hiroshi Yatsuya

    Journal of Occupational Health   Vol. 63 ( 1 ) page: e12278   2021.1

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    <p><b>Background</b>: Diabetes is a major risk factor for cardiovascular diseases (CVD). This systematic review aims to explore the work-related factors among people with diabetes in developing CVD.</p><p><b>Methods</b>: Four electronic databases were searched on 1 February 2021 using a comprehensive search strategy without any time restriction. Two independent researchers screened the articles and extracted data. The risk of bias was assessed independently using the risk of bias assessment tool for non-randomized studies (RoBANS). A narrative synthesis was conducted considering the heterogeneity of the included articles.</p><p><b>Results</b>: A total of five articles incorporating 4 409 810 participants from three geographic regions were included that highlights the research gap. As per the included studies, Occupational drivers with diabetes were at a higher risk of CVD in comparison to the nondrivers, workers with diabetes having a long working hour were at a higher risk of CVD mortality, workers with a lower occupational status were at a higher risk of 10-years stroke risk, and occupational physical activity and occupational commuting lowered the risk of CVD deaths.</p><p><b>Conclusions</b>: This systematic review summarized the available evidence on work-related factors influencing the risk of CVD in people with diabetes. The findings should be interpreted cautiously pondering the limited evidence and imprecision. We identified only five articles related to the topic, and there were no studies from Japan. The scarcity of studies on work-related factors on the prognosis of diabetic patients implies the need for more research in this field. We recommend further exploration of the topic designing primary studies.</p>

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  103. 一般的な代謝結果を予測するための人工ニューラルネットワークおよびロジスティック回帰の比較(Comparison of artificial neural network and logistic regression for predicting common metabolic outcomes)

    He Yupeng, Chiang Chifa, Hirakawa Yoshihisa, Yatsuya Hiroshi

    Journal of Epidemiology   Vol. 31 ( Suppl.1 ) page: 138 - 138   2021.1

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  104. Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study. Reviewed

    Tomomi Kihara, Kazumasa Yamagishi, Kazufumi Honda, Ai Ikeda, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Taiki Yamaji, Taichi Shimazu, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

    Journal of atherosclerosis and thrombosis   Vol. 28 ( 5 ) page: 483 - 490   2021

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    AIM: The fact that low concentrations of high-density lipoprotein cholesterol are associated with the risk of cardiovascular disease is well known, but high-density lipoprotein metabolism has not been fully understood. Apolipoprotein A2 (ApoA2) is the second-most dominant apolipoprotein of high-density lipoprotein. We tested the hypothesis that ApoA2 isoforms are inversely associated with myocardial infarction. METHODS: We measured the plasma levels of three ApoA2 isoforms (ApoA2-ATQ/ATQ, ApoA2-ATQ/AT, ApoA2-AT/AT) in nested case-control study samples of 1:2 from the Japan Public Health-Center-based Study (JPHC Study): 106 myocardial infarction incidence cases and 212 controls. RESULTS: ApoA2-AT/AT was inversely associated with risk of myocardial infarction, in a matched model (OR, 2.78; 95% CI, 1.26-6.09 for lowest compared with the highest quartile), but its association was attenuated after adjustment for smoking only (OR=2.13; 95% CI, 0.91-4.97) or drinking only (OR=2.07; 0.91-4.74), and the multivariable OR was 1.20 (95% CI, 0.41-3.57). Neither ApoA2-ATQ/ATQ nor ApoA2-ATQ/AT was associated with the risk of myocardial infarction. CONCLUSIONS: Our nested case-control study did not show a significant association of ApoA2 isoforms with a risk of myocardial infarction.

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  105. Estimation of 10-Year Risk of Death from Coronary Heart Disease, Stroke, and Cardiovascular Disease in a Pooled Analysis of Japanese Cohorts: EPOCH-JAPAN. Reviewed

    Yuanying Li, Hiroshi Yatsuya, Sachiko Tanaka, Hiroyasu Iso, Akira Okayama, Ichiro Tsuji, Kiyomi Sakata, Yoshihiro Miyamoto, Hirotsugu Ueshima, Katsuyuki Miura, Yoshitaka Murakami, Tomonori Okamura

    Journal of atherosclerosis and thrombosis   Vol. 28 ( 8 ) page: 816 - 825   2021

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    AIMS: We aimed to develop and validate risk prediction models to estimate the absolute 10-year risk of death from coronary heart disease (CHD), stroke, and cardiovascular disease (CVD). METHODS: We evaluated a total of 44,869 individuals aged 40-79 years from eight Japanese prospective cohorts to derive coefficients of risk equations using cohort-stratified Cox proportional hazard regression models. Discrimination (C-index) of the equation was examined in each cohort and summarised using random-effect meta-analyses. Calibration of the equation was assessed using Hosmer-Lemeshow chi-squared statistic. RESULTS: Within a median follow-up of 12.7 years, we observed 765 deaths due to CVD (276 CHDs and 489 strokes). After backward selection, age, sex, current smoking, systolic blood pressure (SBP), proteinuria, prevalent diabetes mellitus, the ratio of total cholesterol to high-density lipoprotein cholesterol (TC/HDLC), interaction terms of age by SBP, and age by current smoking were retained as predictors for CHD. Sex was excluded in the stroke equation. We did not consider TC/HDLC as a risk factor for the stroke and CVD equations. The pooled C-indices for CHD, stroke, and CVD were 0.83, 0.80, and 0.81, respectively, and the corresponding p-values of the Hosmer-Lemeshow tests were 0.18, 0.003, and 0.25, respectively. CONCLUSIONS: Risk equations in the present study can adequately estimate the absolute 10-year risk of death from CHD, stroke, and CVD. Future work will evaluate the system as an education and risk communication tool for primary prevention of CHD and stroke.

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  106. Pelvic exenteration associated with future renal dysfunction. Reviewed

    Masanori Sando, Kay Uehara, Yuanying Li, Toshisada Aiba, Atsushi Ogura, Tomoki Ebata, Yasuhiro Kodera, Hiroshi Yatsuya, Masato Nagino

    Surgery today   Vol. 50 ( 12 ) page: 1601 - 1609   2020.12

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    PURPOSE: This study aimed to clarify the long-term change in the renal function after pelvic exenteration (PE) and to evaluate the risk factors for any future dysfunction. METHODS: This study comprised 40 patients. A greater than 25% decline in the estimated glomerular filtration rate (eGFR) at 3 years was defined as early renal function disorder (ERFD), possibly predicting future chronic kidney disease (CKD). RESULTS: In the entire cohort, the median eGFR decreased by 23% at 3 years, and CKD developed in 50%. The patients were divided into the ERFD (n = 16) and non-ERFD (n = 24) groups. In the ERFD group, the eGFR significantly decreased by 28% during the first 1.5 years and continued to decline after that, resulting in 81.3% of patients reaching CKD, whereas it was 4% and 37.5%, respectively, in the non-ERFD group. In a growth model analysis, late urinary tract complications (UTC) and small bowel obstruction were shown to be risk factors for ERFD. CONCLUSION: Although PE was associated with a high incidence of future CKD, ERFD could predict it. Close observation of the eGFR decline over 1.5 years might be beneficial to identify ERFD patients. High-risk patients with late UTC and small bowel obstruction should, therefore, be observed carefully.

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  107. Increased risk of occupational trichloroethylene hypersensitivity syndrome at exposure levels higher than 15 mg/L of urinary trichloroacetic acid, regardless of whether the patients had the HLA-B*13:01 allele. Reviewed International coauthorship International journal

    Hailan Wang, Tamie Nakajima, Yuki Ito, Hisao Naito, Na Zhao, Hongling Li, Xinxiang Qiu, Lihua Xia, Jiabin Chen, Qifeng Wu, Laiyu Li, Hanlin Huang, Yukie Yanagiba, Hongyung Qu, Hiroshi Yatsuya, Michihiro Kamijima

    Environmental research   Vol. 191   page: 109972 - 109972   2020.12

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    Occupational trichloroethylene (TCE) exposure can cause hypersensitivity syndrome (TCE-HS). The human leukocyte antigen (HLA)-B*13:01 is reportedly an important allele involved in TCE-HS onset. However, the threshold exposure level causing TCE-HS in relation to HLA-B*13:01 remains unknown. We conducted a case-control study comprising 37 TCE-HS patients and 97 age- and sex-matched TCE-tolerant controls from the Han Chinese population. Urine and blood of patients were collected on the first day of hospitalization, and those of controls were collected at the end of their shifts. Urinary trichloroacetic acid (TCA) was measured as an exposure marker, and end-of-shift levels in the patients were estimated using the biological half-life of 83.7 h. HLA-B genotype was identified using DNA from blood. Crude odds ratios (ORs) for TCE-HS in the groups with urinary TCA concentration >15 mg/L to ≤50 mg/L and of >50 mg/L were 21.9 [95% confidence interval (CI) 4.2-114.1] and 27.6 (6.1-125.8), respectively, when the group with urinary TCA ≤15 mg/L was used as a reference. The frequency of HLA-B*13:01, the most common allele in the patients, was 62.2% (23/37), which was significantly higher than 17.5% (17/97) in the TCE-tolerant controls, with a crude OR of 8.4 (3.1-22.6). The mutually-adjusted ORs for urinary TCA >15 to ≤50 mg/L, >50 mg/L, and for HLA-B*13:01 were 33.4 (4.1-270.8), 34.0 (5.3-217.1), and 11.0 (2.4-50.7), respectively. In conclusion, reduction of TCE exposure to ≤15 mg/L is required for TCE-HS prevention because urinary TCA concentration >15 mg/L showed increased risk of TCE-HS, regardless of whether the patients had the HLA-B*13:01 allele.

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  108. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 Reviewed International coauthorship

    Gregory A. Roth, George A. Mensah, Catherine O. Johnson, Giovanni Addolorato, Enrico Ammirati, Larry M. Baddour, Noël C. Barengo, Andrea Z. Beaton, Emelia J. Benjamin, Catherine P. Benziger, Aimé Bonny, Michael Brauer, Marianne Brodmann, Thomas J. Cahill, Jonathan Carapetis, Alberico L. Catapano, Sumeet S. Chugh, Leslie T. Cooper, Josef Coresh, Michael Criqui, Nicole DeCleene, Kim A. Eagle, Sophia Emmons-Bell, Valery L. Feigin, Joaquim Fernández-Solà, Gerry Fowkes, Emmanuela Gakidou, Scott M. Grundy, Feng J. He, George Howard, Frank Hu, Lesley Inker, Ganesan Karthikeyan, Nicholas Kassebaum, Walter Koroshetz, Carl Lavie, Donald Lloyd-Jones, Hong S. Lu, Antonio Mirijello, Awoke Misganaw Temesgen, Ali Mokdad, Andrew E. Moran, Paul Muntner, Jagat Narula, Bruce Neal, Mpiko Ntsekhe, Glaucia Moraes de Oliveira, Catherine Otto, Mayowa Owolabi, Michael Pratt, Sanjay Rajagopalan, Marissa Reitsma, Antonio Luiz P. Ribeiro, Nancy Rigotti, Anthony Rodgers, Craig Sable, Saate Shakil, Karen Sliwa-Hahnle, Benjamin Stark, Johan Sundström, Patrick Timpel, Imad M. Tleyjeh, Marco Valgimigli, Theo Vos, Paul K. Whelton, Magdi Yacoub, Liesl Zuhlke, Christopher Murray, Valentin Fuster, Gregory A. Roth, George A. Mensah, Catherine O. Johnson, Giovanni Addolorato, Enrico Ammirati, Larry M. Baddour, Noel C. Barengo, Andrea Beaton, Emelia J. Benjamin, Catherine P. Benziger, Aime Bonny, Michael Brauer, Marianne Brodmann, Thomas J. Cahill, Jonathan R. Carapetis, Alberico L. Catapano, Sumeet Chugh, Leslie T. Cooper, Josef Coresh, Michael H. Criqui, Nicole K. DeCleene, Kim A. Eagle, Sophia Emmons-Bell, Valery L. Feigin, Joaquim Fernández-Sola, F. Gerry R. Fowkes, Emmanuela Gakidou, Scott M. Grundy, Feng J. He, George Howard, Frank Hu, Lesley Inker, Ganesan Karthikeyan, Nicholas J. Kassebaum, Walter J. Koroshetz, Carl Lavie, Donald Lloyd-Jones, Hong S. Lu, Antonio Mirijello, Awoke T. Misganaw, Ali H. Mokdad, Andrew E. Moran, Paul Muntner, Jagat Narula, Bruce Neal, Mpiko Ntsekhe, Gláucia M.M. Oliveira, Catherine M. Otto, Mayowa O. Owolabi, Michael Pratt, Sanjay Rajagopalan, Marissa B. Reitsma, Antonio Luiz P. Ribeiro, Nancy A. Rigotti, Anthony Rodgers, Craig A. Sable, Saate S. Shakil, Karen Sliwa, Benjamin A. Stark, Johan Sundström, Patrick Timpel, Imad I. Tleyjeh, Marco Valgimigli, Theo Vos, Paul K. Whelton, Magdi Yacoub, Liesl J. Zuhlke, Mohsen Abbasi-Kangevari, Alireza Abdi, Aidin Abedi, Victor Aboyans, Woldu A. Abrha, Eman Abu-Gharbieh, Abdelrahman I. Abushouk, Dilaram Acharya, Tim Adair, Oladimeji M. Adebayo, Zanfina Ademi, Shailesh M. Advani, Khashayar Afshari, Ashkan Afshin, Gina Agarwal, Pradyumna Agasthi, Sohail Ahmad, Sepideh Ahmadi, Muktar B. Ahmed, Budi Aji, Yonas Akalu, Wuraola Akande-Sholabi, Addis Aklilu, Chisom J. Akunna, Fares Alahdab, Ayman Al-Eyadhy, Khalid F. Alhabib, Sheikh M. Alif, Vahid Alipour, Syed M. Aljunid, François Alla, Amir Almasi-Hashiani, Sami Almustanyir, Rajaa M. Al-Raddadi, Adeladza K. Amegah, Saeed Amini, Arya Aminorroaya, Hubert Amu, Dickson A. Amugsi, Robert Ancuceanu, Deanna Anderlini, Tudorel Andrei, Catalina Liliana Andrei, Alireza Ansari-Moghaddam, Zelalem A. Anteneh, Ippazio Cosimo Antonazzo, Benny Antony, Razique Anwer, Lambert T. Appiah, Jalal Arabloo, Johan Ärnlöv, Kurnia D. Artanti, Zerihun Ataro, Marcel Ausloos, Leticia Avila-Burgos, Asma T. Awan, Mamaru A. Awoke, Henok T. Ayele, Muluken A. Ayza, Samad Azari, Darshan B. B, Nafiseh Baheiraei, Atif A. Baig, Ahad Bakhtiari, Maciej Banach, Palash C. Banik, Emerson A. Baptista, Miguel A. Barboza, Lingkan Barua, Sanjay Basu, Neeraj Bedi, Yannick Béjot, Derrick A. Bennett, Isabela M. Bensenor, Adam E. Berman, Yihienew M. Bezabih, Akshaya S. Bhagavathula, Sonu Bhaskar, Krittika Bhattacharyya, Ali Bijani, Boris Bikbov, Mulugeta M. Birhanu, Archith Boloor, Luisa C. Brant, Hermann Brenner, Nikolay I. Briko, Zahid A. Butt, Florentino Luciano Caetano dos Santos, Leah E. Cahill, Lucero Cahuana-Hurtado, Luis A. Cámera, Ismael R. Campos-Nonato, Carlos Cantu-Brito, Josip Car, Juan J. Carrero, Felix Carvalho, Carlos A. Castañeda-Orjuela, Ferrán Catalá-López, Ester Cerin, Jaykaran Charan, Vijay Kumar Chattu, Simiao Chen, Ken L. Chin, Jee-Young J. Choi, Dinh-Toi Chu, Sheng-Chia Chung, Massimo Cirillo, Sean Coffey, Sara Conti, Vera M. Costa, David K. Cundiff, Omid Dadras, Baye Dagnew, Xiaochen Dai, Albertino A.M. Damasceno, Lalit Dandona, Rakhi Dandona, Kairat Davletov, Vanessa De la Cruz-Góngora, Fernando P. De la Hoz, Jan-Walter De Neve, Edgar Denova-Gutiérrez, Meseret Derbew Molla, Behailu T. Derseh, Rupak Desai, Günther Deuschl, Samath D. Dharmaratne, Meghnath Dhimal, Raja Ram Dhungana, Mostafa Dianatinasab, Daniel Diaz, Shirin Djalalinia, Klara Dokova, Abdel Douiri, Bruce B. Duncan, Andre R. Duraes, Arielle W. Eagan, Sanam Ebtehaj, Aziz Eftekhari, Sahar Eftekharzadeh, Michael Ekholuenetale, Nevine El Nahas, Islam Y. Elgendy, Muhammed Elhadi, Shaimaa I. El-Jaafary, Sadaf Esteghamati, Atkilt E. Etisso, Oghenowede Eyawo, Ibtihal Fadhil, Emerito Jose A. Faraon, Pawan S. Faris, Medhat Farwati, Farshad Farzadfar, Eduarda Fernandes, Carlota Fernandez Prendes, Pietro Ferrara, Irina Filip, Florian Fischer, David Flood, Takeshi Fukumoto, Mohamed M. Gad, Shilpa Gaidhane, Morsaleh Ganji, Jalaj Garg, Abadi K. Gebre, Birhan G. Gebregiorgis, Kidane Z. Gebregzabiher, Gebreamlak G. Gebremeskel, Lemma Getacher, Abera Getachew Obsa, Alireza Ghajar, Ahmad Ghashghaee, Nermin Ghith, Simona Giampaoli, Syed Amir Gilani, Paramjit S. Gill, Richard F. Gillum, Ekaterina V. Glushkova, Elena V. Gnedovskaya, Mahaveer Golechha, Kebebe B. Gonfa, Amir Hossein Goudarzian, Alessandra C. Goulart, Jenny S. Guadamuz, Avirup Guha, Yuming Guo, Rajeev Gupta, Vladimir Hachinski, Nima Hafezi-Nejad, Teklehaimanot G. Haile, Randah R. Hamadeh, Samer Hamidi, Graeme J. Hankey, Arief Hargono, Risky K. Hartono, Maryam Hashemian, Abdiwahab Hashi, Shoaib Hassan, Hamid Y. Hassen, Rasmus J. Havmoeller, Simon I. Hay, Khezar Hayat, Golnaz Heidari, Claudiu Herteliu, Ramesh Holla, Mostafa Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Mowafa Househ, Junjie Huang, Ayesha Humayun, Ivo Iavicoli, Charles U. Ibeneme, Segun E. Ibitoye, Olayinka S. Ilesanmi, Irena M. Ilic, Milena D. Ilic, Usman Iqbal, Seyed Sina N. Irvani, Sheikh Mohammed Shariful Islam, Rakibul M. Islam, Hiroyasu Iso, Masao Iwagami, Vardhmaan Jain, Tahereh Javaheri, Sathish Kumar Jayapal, Shubha Jayaram, Ranil Jayawardena, Panniyammakal Jeemon, Ravi P. Jha, Jost B. Jonas, Jitendra Jonnagaddala, Farahnaz Joukar, Jacek J. Jozwiak, Mikk Jürisson, Ali Kabir, Tanvir Kahlon, Rizwan Kalani, Rohollah Kalhor, Ashwin Kamath, Ibrahim Kamel, Himal Kandel, Amit Kandel, André Karch, Ayele Semachew Kasa, Patrick D.M.C. Katoto, Gbenga A. Kayode, Yousef S. Khader, Mohammad Khammarnia, Muhammad S. Khan, Md Nuruzzaman Khan, Maseer Khan, Ejaz A. Khan, Khaled Khatab, Gulam M.A. Kibria, Yun Jin Kim, Gyu Ri Kim, Ruth W. Kimokoti, Sezer Kisa, Adnan Kisa, Mika Kivimäki, Dhaval Kolte, Ali Koolivand, Vladimir A. Korshunov, Sindhura Lakshmi Koulmane Laxminarayana, Ai Koyanagi, Kewal Krishan, Vijay Krishnamoorthy, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Vaman Kulkarni, G. Anil Kumar, Nithin Kumar, Om P. Kurmi, Dian Kusuma, Gene F. Kwan, Carlo La Vecchia, Ben Lacey, Tea Lallukka, Qing Lan, Savita Lasrado, Zohra S. Lassi, Paolo Lauriola, Wayne R. Lawrence, Avula Laxmaiah, Kate E. LeGrand, Ming-Chieh Li, Bingyu Li, Shanshan Li, Stephen S. Lim, Lee-Ling Lim, Hualiang Lin, Ziqiang Lin, Ro-Ting Lin, Xuefeng Liu, Alan D. Lopez, Stefan Lorkowski, Paulo A. Lotufo, Alessandra Lugo, Nirmal K. M, Fabiana Madotto, Morteza Mahmoudi, Azeem Majeed, Reza Malekzadeh, Ahmad A. Malik, Abdullah A. Mamun, Navid Manafi, Mohammad Ali Mansournia, Lorenzo G. Mantovani, Santi Martini, Manu R. Mathur, Giampiero Mazzaglia, Suresh Mehata, Man Mohan Mehndiratta, Toni Meier, Ritesh G. Menezes, Atte Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Tomasz Miazgowski, Irmina Maria Michalek, Ted R. Miller, Erkin M. Mirrakhimov, Hamed Mirzaei, Babak Moazen, Masoud Moghadaszadeh, Yousef Mohammad, Dara K. Mohammad, Shafiu Mohammed, Mohammed A. Mohammed, Yaser Mokhayeri, Mariam Molokhia, Ahmed A. Montasir, Ghobad Moradi, Rahmatollah Moradzadeh, Paula Moraga, Lidia Morawska, Ilais Moreno Velásquez, Jakub Morze, Sumaira Mubarik, Walter Muruet, Kamarul Imran Musa, Ahamarshan J. Nagarajan, Mahdi Nalini, Vinay Nangia, Atta Abbas Naqvi, Sreenivas Narasimha Swamy, Bruno R. Nascimento, Vinod C. Nayak, Javad Nazari, Milad Nazarzadeh, Ruxandra I. Negoi, Sandhya Neupane Kandel, Huong L.T. Nguyen, Molly R. Nixon, Bo Norrving, Jean Jacques Noubiap, Brice E. Nouthe, Christoph Nowak, Oluwakemi O. Odukoya, Felix A. Ogbo, Andrew T. Olagunju, Hans Orru, Alberto Ortiz, Samuel M. Ostroff, Jagadish Rao Padubidri, Raffaele Palladino, Adrian Pana, Songhomitra Panda-Jonas, Utsav Parekh, Eun-Cheol Park, Mojtaba Parvizi, Fatemeh Pashazadeh Kan, Urvish K. Patel, Mona Pathak, Rajan Paudel, Veincent Christian F. Pepito, Arokiasamy Perianayagam, Norberto Perico, Hai Q. Pham, Thomas Pilgrim, Michael A. Piradov, Farhad Pishgar, Vivek Podder, Roman V. Polibin, Akram Pourshams, Dimas R.A. Pribadi, Navid Rabiee, Mohammad Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Amir Masoud Rahmani, Ivo Rakovac, Pradhum Ram, Sudha Ramalingam, Juwel Rana, Priyanga Ranasinghe, Sowmya J. Rao, Priya Rathi, Lal Rawal, Wasiq F. Rawasia, Reza Rawassizadeh, Giuseppe Remuzzi, Andre M.N. Renzaho, Aziz Rezapour, Seyed Mohammad Riahi, Ross L. Roberts-Thomson, Leonardo Roever, Peter Rohloff, Michele Romoli, Gholamreza Roshandel, Godfrey M. Rwegerera, Seyedmohammad Saadatagah, Maha M. Saber-Ayad, Siamak Sabour, Simona Sacco, Masoumeh Sadeghi, Sahar Saeedi Moghaddam, Saeed Safari, Amirhossein Sahebkar, Sana Salehi, Hamideh Salimzadeh, Mehrnoosh Samaei, Abdallah M. Samy, Itamar S. Santos, Milena M. Santric-Milicevic, Nizal Sarrafzadegan, Arash Sarveazad, Thirunavukkarasu Sathish, Monika Sawhney, Mete Saylan, Maria I. Schmidt, Aletta E. Schutte, Subramanian Senthilkumaran, Sadaf G. Sepanlou, Feng Sha, Saeed Shahabi, Izza Shahid, Masood A. Shaikh, Mahdi Shamali, Morteza Shamsizadeh, Md Shajedur Rahman Shawon, Aziz Sheikh, Mika Shigematsu, Min-Jeong Shin, Jae Il Shin, Rahman Shiri, Ivy Shiue, Kerem Shuval, Soraya Siabani, Tariq J. Siddiqi, Diego A.S. Silva, Jasvinder A. Singh, Ambrish Singh Mtech, Valentin Y. Skryabin, Anna A. Skryabina, Amin Soheili, Emma E. Spurlock, Leo Stockfelt, Stefan Stortecky, Saverio Stranges, Rizwan Suliankatchi Abdulkader, Hooman Tadbiri, Eyayou G. Tadesse, Degena B. Tadesse, Masih Tajdini, Md Tariqujjaman, Berhane F. Teklehaimanot, Mohamad-Hani Temsah, Ayenew K. Tesema, Bhaskar Thakur, Kavumpurathu R. Thankappan, Rekha Thapar, Amanda G. Thrift, Binod Timalsina, Marcello Tonelli, Mathilde Touvier, Marcos R. Tovani-Palone, Avnish Tripathi, Jaya P. Tripathy, Thomas C. Truelsen, Guesh M. Tsegay, Gebiyaw W. Tsegaye, Nikolaos Tsilimparis, Biruk S. Tusa, Stefanos Tyrovolas, Krishna Kishore Umapathi, Brigid Unim, Bhaskaran Unnikrishnan, Muhammad S. Usman, Muthiah Vaduganathan, Pascual R. Valdez, Tommi J. Vasankari, Diana Z. Velazquez, Narayanaswamy Venketasubramanian, Giang T. Vu, Isidora S. Vujcic, Yasir Waheed, Yanzhong Wang, Fang Wang, Jingkai Wei, Robert G. Weintraub, Abrha H. Weldemariam, Ronny Westerman, Andrea S. Winkler, Charles S. Wiysonge, Charles D.A. Wolfe, Befikadu Legesse Wubishet, Gelin Xu, Ali Yadollahpour, Kazumasa Yamagishi, Lijing L. Yan, Srikanth Yandrapalli, Yuichiro Yano, Hiroshi Yatsuya, Tomas Y. Yeheyis, Yigizie Yeshaw, Christopher S. Yilgwan, Naohiro Yonemoto, Chuanhua Yu, Hasan Yusefzadeh, Geevar Zachariah, Sojib Bin Zaman, Muhammed S. Zaman, Maryam Zamanian, Ramin Zand, Alireza Zandifar, Afshin Zarghi, Mikhail S. Zastrozhin, Anasthasia Zastrozhina, Zhi-Jiang Zhang, Yunquan Zhang, Wangjian Zhang, Chenwen Zhong, Zhiyong Zou, Yves Miel H. Zuniga, Christopher J.L. Murray, Valentin Fuster

    Journal of the American College of Cardiology   Vol. 76 ( 25 ) page: 2982 - 3021   2020.12

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  109. Inherited chromosomally integrated human herpesvirus 6 and autoimmune connective tissue diseases. Reviewed International journal

    Yoshiki Kawamura, Takako Hashimoto, Hiroki Miura, Kei Kozawa, Akiko Yoshikawa, Naomi Ikeda, Hiroshi Yatsuya, Hidekata Yasuoka, Tetsushi Yoshikawa

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology   Vol. 132   page: 104656 - 104656   2020.11

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    BACKGROUND: Entire genome of human herpesvirus 6 (HHV-6) that integrates into human chromosomes is called chromosomally integrated HHV-6 (ciHHV-6). Several viral infections have been suggested to be involved in autoimmune connective tissue diseases (CTDs). Reactivated HHV-6 from the integrated viral genome can induce immune responses against the virus. Thus, it is plausible that ciHHV-6 is associated with autoimmune CTDs. OBJECTIVES: We sought to determine whether the prevalence of ciHHV-6 was significantly higher in patients with autoimmune CTDs than in a healthy population. STUDY DESIGN: A total of 846 peripheral blood samples collected from autoimmune CTD patients were analyzed. Since there was a large number of samples, they were pooled into 24 samples per group. Copy numbers of HHV-6 DNA were measured by real-time PCR. The threshold level for distinguishing between ciHHV-6 and active viral infection and the reliability of pooled DNA analysis were examined as initial validation experiments. RESULTS: The threshold level was 1.6 × 10^6 copy/mL in whole blood. The reliability of pooled DNA analysis to identify one ciHHV-6 sample among 23 HHV-6 DNA-negative samples was high. No HHV-6 DNA was detected in any of the pooled DNA samples collected from the patients. The probability of the present study including the 846 autoimmune CTD patient's samples was statistically not different with a healthy Japanese population which was 0.2 % or 0.6 %. CONCLUSIONS: There was no significant difference in the prevalence of ciHHV-6 between a healthy population and patients with autoimmune CTDs.

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  110. Positive Association of Physical Activity with Both Objective and Perceived Measures of the Neighborhood Environment among Older Adults: The Aichi Workers' Cohort Study. Reviewed International journal

    Yuanying Li, Hiroshi Yatsuya, Tomoya Hanibuchi, Atsuhiko Ota, Hisao Naito, Rei Otsuka, Chiyoe Murata, Yoshihisa Hirakawa, Chifa Chiang, Mayu Uemura, Koji Tamakoshi, Atsuko Aoyama

    International journal of environmental research and public health   Vol. 17 ( 21 ) page: 1 - 14   2020.11

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    We examined the association between objective and perceived neighborhood characteristics and self-reported leisure-time physical activity (PA) in older Japanese residents living in areas ranging from metropolitan to rural in 2016. Objective measures used were walkability and the numbers of parks/green spaces and sports facilities within 500 or 1000 m of subjects' homes, calculated using geographic information systems. Subjective measures were the subjects' perceptions of their neighborhoods, assessed using a structured questionnaire. All variables were divided into three groups, and the lowest tertile was used as the reference. We assessed the location and frequency of strolling or brisk walking, moderate-intensity PA, and vigorous-intensity PA (sports) using a self-reported questionnaire and defined as performing a certain type of PA 3-4 times/week as a habit. Living in a neighborhood in the highest tertile for walkability and number of parks/green spaces as well as perception of having good access to recreational facilities, observing others exercising and the presence of walkable sidewalks was associated with walking and sports habits (multivariable odds ratios (ORs): 1.33-2.46, all p < 0.05). Interestingly, objective measures of PA-friendly environmental features were inversely associated with moderate-intensity PA habits, potentially because moderate-intensity PA consisted predominantly of gardening. In conclusion, living in an environment supportive of PA, whether objectively or subjectively measured, is related to leisure-time PA habits among older Japanese adults.

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  111. Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets. Reviewed International coauthorship International journal

    Kunihiro Matsushita, Simerjot K Jassal, Yingying Sang, Shoshana H Ballew, Morgan E Grams, Aditya Surapaneni, Johan Arnlov, Nisha Bansal, Milica Bozic, Hermann Brenner, Nigel J Brunskill, Alex R Chang, Rajkumar Chinnadurai, Massimo Cirillo, Adolfo Correa, Natalie Ebert, Kai-Uwe Eckardt, Ron T Gansevoort, Orlando Gutierrez, Farzad Hadaegh, Jiang He, Shih-Jen Hwang, Tazeen H Jafar, Takamasa Kayama, Csaba P Kovesdy, Gijs W Landman, Andrew S Levey, Donald M Lloyd-Jones, Rupert W Major, Katsuyuki Miura, Paul Muntner, Girish N Nadkarni, David Mj Naimark, Christoph Nowak, Takayoshi Ohkubo, Michelle J Pena, Kevan R Polkinghorne, Charumathi Sabanayagam, Toshimi Sairenchi, Markus P Schneider, Varda Shalev, Michael Shlipak, Marit D Solbu, Nikita Stempniewicz, James Tollitt, José M Valdivielso, Joep van der Leeuw, Angela Yee-Moon Wang, Chi-Pang Wen, Mark Woodward, Kazumasa Yamagishi, Hiroshi Yatsuya, Luxia Zhang, Elke Schaeffner, Josef Coresh

    EClinicalMedicine   Vol. 27   page: 100552 - 100552   2020.10

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    Background: Chronic kidney disease (CKD) measures (estimated glomerular filtration rate [eGFR] and albuminuria) are frequently assessed in clinical practice and improve the prediction of incident cardiovascular disease (CVD), yet most major clinical guidelines do not have a standardized approach for incorporating these measures into CVD risk prediction. "CKD Patch" is a validated method to calibrate and improve the predicted risk from established equations according to CKD measures. Methods: Utilizing data from 4,143,535 adults from 35 datasets, we developed several "CKD Patches" incorporating eGFR and albuminuria, to enhance prediction of risk of atherosclerotic CVD (ASCVD) by the Pooled Cohort Equation (PCE) and CVD mortality by Systematic COronary Risk Evaluation (SCORE). The risk enhancement by CKD Patch was determined by the deviation between individual CKD measures and the values expected from their traditional CVD risk factors and the hazard ratios for eGFR and albuminuria. We then validated this approach among 4,932,824 adults from 37 independent datasets, comparing the original PCE and SCORE equations (recalibrated in each dataset) to those with addition of CKD Patch. Findings: We confirmed the prediction improvement with the CKD Patch for CVD mortality beyond SCORE and ASCVD beyond PCE in validation datasets (Δc-statistic 0.027 [95% CI 0.018-0.036] and 0.010 [0.007-0.013] and categorical net reclassification improvement 0.080 [0.032-0.127] and 0.056 [0.044-0.067], respectively). The median (IQI) of the ratio of predicted risk for CVD mortality with CKD Patch vs. the original prediction with SCORE was 2.64 (1.89-3.40) in very high-risk CKD (e.g., eGFR 30-44 ml/min/1.73m2 with albuminuria ≥30 mg/g), 1.86 (1.48-2.44) in high-risk CKD (e.g., eGFR 45-59 ml/min/1.73m2 with albuminuria 30-299 mg/g), and 1.37 (1.14-1.69) in moderate risk CKD (e.g., eGFR 60-89 ml/min/1.73m2 with albuminuria 30-299 mg/g), indicating considerable risk underestimation in CKD with SCORE. The corresponding estimates for ASCVD with PCE were 1.55 (1.37-1.81), 1.24 (1.10-1.54), and 1.21 (0.98-1.46). Interpretation: The "CKD Patch" can be used to quantitatively enhance ASCVD and CVD mortality risk prediction equations recommended in major US and European guidelines according to CKD measures, when available. Funding: US National Kidney Foundation and the NIDDK.

    DOI: 10.1016/j.eclinm.2020.100552

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  112. Correction: The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes. Reviewed International journal

    Madoka Matsushita, Akiko Muramoto, Eri Nomura, Yukari Eguchi, Ayako Kato, Yoshiko Sano, Mai Kabayama, Masashi Arakawa, Yuko Oguma, Daisuke Yabe, Masaaki Matsunaga, Hiroshi Yatsuya, Hiroshi Arima, Kazuyo Tsushita

    Nutrition & diabetes   Vol. 10 ( 1 ) page: 34 - 34   2020.9

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    Following publication, the authors asked to add the following institution to the affiliations of author Madoka Matsushita: Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine Both the PDF and HTML versions of the Article have been updated accordingly.

    DOI: 10.1038/s41387-020-00137-w

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  113. Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for the incidence of type 2 diabetes mellitus among middle-aged Japanese individuals: Aichi Worker's Cohort Study. Reviewed

    Kayo Kaneko, Hiroshi Yatsuya, Yuanying Li, Mayu Uemura, Chifa Chiang, Yoshihisa Hirakawa, Atsuhiko Ota, Koji Tamakoshi, Atsuko Aoyama

    Journal of diabetes investigation   Vol. 11 ( 5 ) page: 1163 - 1169   2020.9

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    AIMS/INTRODUCTION: The Japanese government started a nationwide screening program for metabolic syndrome (MetS) to prevent cardiovascular diseases and diabetes in 2008. Although impaired fasting glucose (IFG) is a strong predictor for type 2 diabetes mellitus, the program does not follow up IFG in non-MetS individuals. This study aimed to examine the risk and the population attributable fraction (PAF) of MetS and IFG for incidence of type 2 diabetes mellitus. MATERIALS AND METHODS: Japanese workers (3,417 men and 714 women) aged 40-64 years without a history of diabetes were prospectively followed. MetS was defined as either abdominal obesity plus two or more metabolic risk factors, or being overweight in the case of normal waist circumference plus three or more metabolic risk factors. IFG was defined as fasting blood glucose 100-125 mg/dL. RESULTS: During a mean 6.3 years, 240 type 2 diabetes mellitus cases were identified. Compared with those without MetS and IFG, the multivariable-adjusted hazard ratios (95% confidence interval) of non-MetS individuals with IFG, MetS individuals without IFG and MetS individuals with IFG for type 2 diabetes mellitus were 4.9 (3.4-7.1), 2.4 (1.6-3.5) and 8.3 (5.9-11.5), respectively. The corresponding PAFs for type 2 diabetes mellitus incidence were 15.6, 9.1 and 29.7%, respectively. CONCLUSIONS: IFG represented a higher risk and PAF than MetS for type 2 diabetes mellitus incidence in middle-aged Japanese individuals. The coexistence of MetS and IFG showed the highest risk and PAF for type 2 diabetes mellitus incidence. The current Japanese MetS screening program should be reconsidered to follow up non-MetS individuals with IFG.

    DOI: 10.1111/jdi.13230

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  114. Milk Intake and Stroke Mortality in the Japan Collaborative Cohort Study-A Bayesian Survival Analysis. Reviewed International coauthorship International journal

    Chaochen Wang, Hiroshi Yatsuya, Yingsong Lin, Tae Sasakabe, Sayo Kawai, Shogo Kikuchi, Hiroyasu Iso, Akiko Tamakoshi

    Nutrients   Vol. 12 ( 9 )   2020.9

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    The aim of this study was to further examine the relationship between milk intake and stroke mortality among the Japanese population. We used data from the Japan Collaborative Cohort (JACC) Study (total number of participants = 110,585, age range: 40-79) to estimate the posterior acceleration factors (AF) as well as the hazard ratios (HR) comparing individuals with different milk intake frequencies against those who never consumed milk at the study baseline. These estimations were computed through a series of Bayesian survival models that employed a Markov Chain Monte Carlo simulation process. In total, 100,000 posterior samples were generated separately through four independent chains after model convergency was confirmed. Posterior probabilites that daily milk consumers had lower hazard or delayed mortality from strokes compared to non-consumers was 99.0% and 78.0% for men and women, respectively. Accordingly, the estimated posterior means of AF and HR for daily milk consumers were 0.88 (95% Credible Interval, CrI: 0.81, 0.96) and 0.80 (95% CrI: 0.69, 0.93) for men and 0.97 (95% CrI: 0.88, 1.10) and 0.95 (95% CrI: 0.80, 1.17) for women. In conclusion, data from the JACC study provided strong evidence that daily milk intake among Japanese men was associated with delayed and lower risk of mortality from stroke especially cerebral infarction.

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  115. Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17 Reviewed International coauthorship International journal

    Deshpande Aniruddha, Miller-Petrie Molly K., Lindstedt Paulina A., Baumann Mathew M., Johnson Kimberly B., Blacker Brigette F., Abbastabar Hedayat, Abd-Allah Foad, Abdelalim Ahmed, Abdollahpour Ibrahim, Abegaz Kedir Hussein, Abejie Ayenew Negesse, Abreu Lucas Guimaraes, Abrigo Michael R. M., Abualhasan Ahmed, Accrombessi Manfred Mario Kokou, Adamu Abdu A., Adebayo Oladimeji M., Adedeji Isaac Akinkunmi, Adedoyin Rufus Adesoji, Adekanmbi Victor, Adetokunboh Olatunji O., Adhikari Tara Ballav, Afarideh Mohsen, Agudelo-Botero Marcela, Ahmadi Mehdi, Ahmadi Keivan, Ahmed Muktar Beshir, Ahmed Anwar E., Akalu Temesgen Yihunie, Akanda Ali S., Alahdab Fares, Al-Aly Ziyad, Alam Samiah, Alam Noore, Alamene Genet Melak, Alanzi Turki M., Albright James, Albujeer Ammar, Alcalde-Rabanal Jacqueline Elizabeth, Alebel Animut, Alemu Zewdie Aderaw, Ali Muhammad, Alijanzadeh Mehran, Alipour Vahid, Aljunid Syed Mohamed, Almasi Ali, Almasi-Hashiani Amir, Al-Mekhlafi Hesham M., Altirkawi Khalid A., Alvis-Guzman Nelson, Alvis-Zakzuk Nelson J., Amini Saeed, Amit Arianna Maever L., Amul Gianna Gayle Herrera, Andrei Catalina Liliana, Anjomshoa Mina, Ansariadi Ansariadi, Antonio Carl Abelardo T., Antony Benny, Antriyandarti Ernoiz, Arabloo Jalal, Aref Hany Mohamed Amin, Aremu Olatunde, Armoon Bahram, Arora Amit, Aryal Krishna K., Arzani Afsaneh, Asadi-Aliabadi Mehran, Asmelash Daniel, Atalay Hagos Tasew, Athari Seyyede Masoume, Athari Seyyed Shamsadin, Atre Sachin R., Ausloos Marcel, Awasthi Shally, Awoke Nefsu, Quintanilla Beatriz Paulina Ayala, Ayano Getinet, Ayanore Martin Amogre, Aynalem Yared Asmare, Azari Samad, Azman Andrew S., Babaee Ebrahim, Badawi Alaa, Bagherzadeh Mojtaba, Bakkannavar Shankar M., Balakrishnan Senthilkumar, Banach Maciej, Banoub Joseph Adel Mattar, Barac Aleksandra, Barboza Miguel A., Barnighausen Till Winfried, Basu Sanjay, Vo Dinh Bay, Bayati Mohsen, Bedi Neeraj, Beheshti Mahya, Behzadifar Meysam, Behzadifar Masoud, Ramirez Diana Fernanda Bejarano, Bell Michelle L., Bennett Derrick A., Benzian Habib, Berbada Dessalegn Ajema, Bernstein Robert S., Bhat Anusha Ganapati, Bhattacharyya Krittika, Bhaumik Soumyadeep, Bhutta Zulfiqar A., Bijani Ali, Bikbov Boris, Bin Sayeed Muhammad Shahdaat, Biswas Raaj Kishore, Bohlouli Somayeh, Boufous Soufiane, Brady Oliver J., Briko Andrey Nikolaevich, Briko Nikolay Ivanovich, Britton Gabrielle B., Brown Alexandria, Nagaraja Sharath Burugina, Butt Zahid A., Camera Luis Alberto, Campos-Nonato Ismael R., Rincon Julio Cesar Campuzano, Cano Jorge, Car Josip, Cardenas Rosario, Carvalho Felix, Castaneda-Orjuela Carlos A., Castro Franz, Cerin Ester, Chalise Binaya, Chattu Vijay Kumar, Chin Ken Lee, Christopher Devasahayam J., Chu Dinh-Toi, Cormier Natalie Maria, Costa Vera Marisa, Cromwell Elizabeth A., Dadi Abel Fekadu Fekadu, Dahiru Tukur, Dahlawi Saad M. A., Dandona Rakhi, Dandona Lalit, Dang Anh Kim, Daoud Farah, Darwesh Aso Mohammad, Darwish Amira Hamed, Daryani Ahmad, Das Jai K., Das Gupta Rajat, Dash Aditya Prasad, Davila-Cervantes Claudio Alberto, Weaver Nicole Davis, De la Hoz Fernando Pio, De Neve Jan-Walter, Demissie Dereje Bayissa, Demoz Gebre Teklemariam, Denova-Gutierrez Edgar, Deribe Kebede, Desalew Assefa, Dharmaratne Samath Dhamminda, Dhillon Preeti, Dhimal Meghnath, Dhungana Govinda Prasad, Diaz Daniel, Dipeolu Isaac Oluwafemi, Hoa Thi, Dolecek Christiane, Doyle Kerrie E., Dubljanin Eleonora, Duraes Andre Rodrigues, Edinur Hisham Atan, Effiong Andem, Eftekhari Aziz, El Nahas Nevine, Zaki Maysaa El Sayed, El Tantawi Maha, Elhabashy Hala Rashad, El-Jaafary Shaimaa I, El-Khatib Ziad, Elkout Hajer, Elsharkawy Aisha, Enany Shymaa, Endalew Daniel Adane, Eshrati Babak, Eskandarieh Sharareh, Etemadi Arash, Ezekannagha Oluchi, Faraon Emerito Jose A., Fareed Mohammad, Faro Andre, Farzadfar Farshad, Fasil Alebachew Fasil, Fazlzadeh Mehdi, Feigin Valery L., Fekadu Wubalem, Fentahun Netsanet, Fereshtehnejad Seyed-Mohammad, Fernandes Eduarda, Filip Irina, Fischer Florian, Flohr Carsten, Foigt Nataliya A., Folayan Morenike Oluwatoyin, Foroutan Masoud, Franklin Richard Charles, Frostad Joseph Jon, Fukumoto Takeshi, Gad Mohamed M., Garcia Gregory M., Gatotoh Augustine Mwangi, Gayesa Reta Tsegaye, Gebremedhin Ketema Bizuwork, Geramo Yilma Chisha Dea, Gesesew Hailay Abrha, Gezae Kebede Embaye, Ghashghaee Ahmad, Sherbaf Farzaneh Ghazi, Gill Tiffany K., Gill Paramjit Singh, Ginindza Themba G., Girmay Alem, Gizaw Zemichael, Goodridge Amador, Gopalani Sameer Vali, Goulart Barbara Niegia Garcia, Goulart Alessandra C., Grada Ayman, Green Manfred S., Gubari Mohammed Ibrahim Mohialdeen, Gugnani Harish Chander, Guido Davide, Guimaraes Rafael Alves, Guo Yuming, Gupta Rajeev, Gupta Rahul, Ha Giang Hai, Haagsma Juanita A., Hafezi-Nejad Nima, Haile Dessalegn H., Haile Michael Tamene, Hall Brian J., Hamidi Samer, Handiso Demelash Woldeyohannes, Haririan Hamidreza, Hariyani Ninuk, Hasaballah Ahmed I, Hasan Mehedi, Hasanzadeh Amir, Hassen Hamid Yimam, Hayelom Desta Haftu, Hegazy Mohamed I, Heibati Behzad, Heidari Behnam, Hendrie Delia, Henok Andualem, Herteliu Claudiu, Heydarpour Fatemeh, de Hidru Hagos Degefa, Hird Thomas R., Chi Linh Hoang, Hollerich Gillian I, Hoogar Praveen, Hossain Naznin, Hosseinzadeh Mehdi, Househ Mowafa, Hu Guoqing, Humayun Ayesha, Hussain Syed Ather, Hussen Mamusha Aman A., Ibitoye Segun Emmanuel, Ilesanmi Olayinka Stephen, Ilic Milena D., Imani-Nasab Mohammad Hasan, Iqbal Usman, Irvani Seyed Sina Naghibi, Islam Sheikh Mohammed Shariful, Ivers Rebecca Q., Iwu Chinwe Juliana, Jahanmehr Nader, Jakovljevic Mihajlo, Jalali Amir, Jayatilleke Achala Upendra, Jenabi Ensiyeh, Jha Ravi Prakash, Jha Vivekanand, Ji John S., Jonas Jost B., Jozwiak Jacek Jerzy, Kabir Ali, Kabir Zubair, Kanchan Tanuj, Karch Andre, Karki Surendra, Kasaeian Amir, Kasahun Gebremicheal Gebreslassie, Kasaye Habtamu Kebebe, Kassa Gebrehiwot G., Kassa Getachew Mullu, Kayode Gbenga A., Kebede Mihiretu M., Keiyoro Peter Njenga, Ketema Daniel Bekele, Khader Yousef Saleh, Khafaie Morteza Abdullatif, Khalid Nauman, Khalilov Rovshan, Khan Ejaz Ahmad, Khan Junaid, Khan Nuruzzaman, Khatab Khaled, Khater Mona M., Khater Amir M., Khayamzadeh Maryam, Khazaei Mohammad, Khosravi Mohammad Hossein, Khubchandani Jagdish, Kiadaliri Ali, Kim Yun Jin, Kimokoti Ruth W., Kisa Sezer, Kisa Adnan, Kochhar Sonali, Kolola Tufa, Komaki Hamidreza, Kosen Soewarta, Koul Parvaiz A., Koyanagi Ai, Krishan Kewal, Defo Barthelemy Kuate, Kugbey Nuworza, Kumar Pushpendra, Kumar G. Anil, Kumar Manasi, Kusuma Dian, La Vecchia Carlo, Lacey Ben, Lal Aparna, Lal Dharmesh Kumar, Lam Hilton, Lami Faris Hasan, Lansingh Van Charles, Lasrado Savita, Lebedev Georgy, Lee Paul H., LeGrand Kate E., Leili Mostafa, Lenjebo Tsegaye Lolaso, Leshargie Cheru Tesema, Levine Aubrey J., Lewycka Sonia, Li Shanshan, Linn Shai, Liu Shiwei, Lopez Jaifred Christian F., Lopukhov Platon D., Abd El Razek Muhammed Magdy, Prasad D. R. Mahadeshwara, Mahasha Phetole Walter, Mahotra Narayan B., Majeed Azeem, Malekzadeh Reza, Malta Deborah Carvalho, Mamun Abdullah A., Manafi Navid, Mansournia Mohammad Ali, Mapoma Chabila Christopher, Martinez Gabriel, Martini Santi, Martins-Melo Francisco Rogerlandio, Mathur Manu Raj, Mayala Benjamin K., Mazidi Mohsen, McAlinden Colm, Meharie Birhanu Geta, Mehndiratta Man Mohan, Nasab Entezar Mehrabi, Mehta Kala M., Mekonnen Teferi, Mekonnen Tefera Chane, Meles Gebrekiros Gebremichael, Meles Hagazi Gebre, Memiah Peter T. N., Memish Ziad A., Mendoza Walter, Menezes Ritesh G., Mereta Seid Tiku, Meretoja Tuomo J., Mestrovic Tomislav, Metekiya Workua Mekonnen, Miazgowski Bartosz, Miller Ted R., Mini G. K., Mirrakhimov Erkin M., Moazen Babak, Mohajer Bahram, Mohammad Yousef, Mohammad Dara K., Mezerji Naser Mohammad Gholi, Mohammadibakhsh Roghayeh, Mohammed Shafiu, Mohammed Jemal Abdu, Mohammed Hassen, Mohebi Farnam, Mokdad Ali H., Moodley Yoshan, Moradi Masoud, Moradi Ghobad, Moradi-Joo Mohammad, Moraga Paula, Morales Linda, Mosapour Abbas, Mosser Jonathan F., Mouodi Simin, Mousavi Seyyed Meysam, Mozaffor Miliva, Munro Sandra B., Muriithi Moses K., Murray Christopher J. L., Musa Kamarul Imran, Mustafa Ghulam, Muthupandian Saravanan, Naderi Mehdi, Nagarajan Ahamarshan Jayaraman, Naghavi Mohsen, Naik Gurudatta, Nangia Vinay, Nascimento Bruno Ramos, Nazari Javad, Ndwandwe Duduzile Edith, Negoi Ionut, Netsere Henok Biresaw, Ngunjiri Josephine W., Cuong Tat Nguyen, Huong Lan Thi Nguyen, Nguyen QuynhAnh P., Nigatu Solomon Gedlu, Ningrum Dina Nur Anggraini, Nnaji Chukwudi A., Nojomi Marzieh, Norheim Ole F., Noubiap Jean Jacques, Oancea Bogdan, Ogbo Felix Akpojene, Oh In-Hwan, Olagunju Andrew T., Olusanya Jacob Olusegun, Olusanya Bolajoko Olubukunola, Onwujekwe Obinna E., Ortega-Altamirano Doris V, Osarenotor Osayomwanbo, Osei Frank B., Owolabi Mayowa O., Mahesh P. A., Padubidri Jagadish Rao, Pakhale Smita, Pana Adrian, Park Eun-Kee, Patel Sangram Kishor, Pathak Ashish, Patle Ajay, Paulos Kebreab, Pepito Veincent Christian Filipino, Perico Norberto, Pervaiz Aslam, Pescarini Julia Moreira, Pesudovs Konrad, Pham Hai Quang, Pigott David M., Pilgrim Thomas, Pirsaheb Meghdad, Poljak Mario, Pollock Ian, Postma Maarten J., Pourmalek Farshad, Pourshams Akram, Prada Sergio I, Preotescu Liliana, Quintana Hedley, Rabiee Navid, Rabiee Mohammad, Radfar Amir, Rafiei Alireza, Rahim Fakher, Rahimi Siavash, Rahimi-Movaghar Vafa, Rahman Muhammad Aziz, Rahman Mohammad Hifz Ur, Rajati Fatemeh, Ranabhat Chhabi Lal, Rao Puja C., Rasella Davide, Rath Goura Kishor, Rawaf Salman, Rawal Lal, Rawasia Wasiq Faraz, Remuzzi Giuseppe, Renjith Vishnu, Renzaho Andre M. N., Resnikoff Serge, Riahi Seyed Mohammad, Ribeiro Ana Isabel, Rickard Jennifer, Roever Leonardo, Ronfani Luca, Rubagotti Enrico, Rubino Salvatore, Saad Anas M., Sabour Siamak, Sadeghi Ehsan, Moghaddam Sahar Saeedi, Safari Yahya, Sagar Rajesh, Sahraian Mohammad Ali, Sajadi S. Mohammad, Salahshoor Mohammad Reza, Salam Nasir, Saleem Ahsan, Salem Hosni, Salem Marwa Rashad, Salimi Yahya, Salimzadeh Hamideh, Samy Abdallah M., Sanabria Juan, Santos Itamar S., Santric-Milicevic Milena M., Sao Jose Bruno Piassi, Saraswathy Sivan Yegnanarayana Iyer, Sarrafzadegan Nizal, Sartorius Benn, Sathian Brijesh, Sathish Thirunavukkarasu, Satpathy Maheswar, Sawhney Monika, Sayyah Mehdi, Sbarra Alyssa N., Schaeffer Lauren E., Schwebel David C., Senbeta Anbissa Muleta, Senthilkumaran Subramanian, Sepanlou Sadaf G., Servan-Mori Edson, Shafieesabet Azadeh, Shaheen Amira A., Shahid Izza, Shaikh Masood Ali, Shalash Ali S., Shams-Beyranvand Mehran, Shamsi MohammadBagher, Shamsizadeh Morteza, Shannawaz Mohammed, Sharafi Kiomars, Sharma Rajesh, Sheikh Aziz, Shetty B. Suresh Kumar, Shiferaw Wondimeneh Shibabaw, Shigematsu Mika, Shin Jae Il, Shiri Rahman, Shirkoohi Reza, Shivakumar K. M., Si Si, Siabani Soraya, Siddiqi Tariq Jamal, Silva Diego Augusto Santos, Singh Virendra, Singh Narinder Pal, Singh Balbir Bagicha Singh, Singh Jasvinder A., Singh Ambrish, Sinha Dhirendra Narain, Sisay Malede Mequanent, Skiadaresi Eirini, Smith David L., Filho Adauto Martins Soares, Sobhiyeh Mohammad Reza, Sokhan Anton, Soriano Joan B., Sorrie Muluken Bekele, Soyiri Ireneous N., Spurlock Emma Elizabeth, Sreeramareddy Chandrashekhar T., Sudaryanto Agus, Sufiyan Mu'awiyyah Babale, Suleria Hafiz Ansar Rasul, Sykes Bryan L., Tabares-Seisdedos Rafael, Tabuchi Takahiro, Tadesse Degena Bahrey, Tarigan Ingan Ukur, Taye Bineyam, Tefera Yonatal Mesfin, Tehrani-Banihashemi Arash, Tekelemedhin Shishay Wahdey, Tekle Merhawi Gebremedhin, Temsah Mohamad-Hani, Tesfay Berhe Etsay, Tesfay Fisaha Haile, Tessema Zemenu Tadesse, Thankappan Kavumpurathu Raman, ThekkePurakkal Akhil Soman, Thomas Nihal, Thompson Robert L., Thomson Alan J., Topor-Madry Roman, Tovani-Palone Marcos Roberto, Traini Eugenio, Bach Xuan Tran, Khanh Bao Tran, Ullah Irfan, Unnikrishnan Bhaskaran, Usman Muhammad Shariq, Uthman Olalekan A., Uzochukwu Benjamin S. Chudi, Valdez Pascual R., Varughese Santosh, Veisani Yousef, Violante Francesco S., Vollmer Sebastian, Whawariat Feleke Gebremeskel, Waheed Yasir, Wallin Mitchell Taylor, Wang Yuan-Pang, Wang Yafeng, Wangdi Kinley, Weiss Daniel J., Weldesamuel Girmay Teklay, Werkneh Adhena Ayaliew, Westerman Ronny, Wiangkham Taweewat, Wiens Kirsten E., Wijeratne Tissa, Wiysonge Charles Shey, Wolde Haileab Fekadu, Wondafrash Dawit Zewdu, Wonde Tewodros Eshete, Worku Getasew Taddesse, Yadollahpour Ali, Jabbari Seyed Hossein Yahyazadeh, Yamada Tomohide, Yaseri Mehdi, Yatsuya Hiroshi, Yeshaneh Alex, Yilma Mekdes Tigistu, Yip Paul, Yisma Engida, Yonemoto Naohiro, Younis Mustafa Z., Yousof Hebat-Allah Salah A., Yu Chuanhua, Yusefzadeh Hasan, Zadey Siddhesh, Moghadam Telma Zahirian, Zaidi Zoubida, Bin Zaman Sojib, Zamani Mohammad, Zandian Hamed, Zar Heather J., Zerfu Taddese Alemu, Zhang Yunquan, Ziapour Arash, Zodpey Sanjay, Zuniga Yves Miel H., Hay Simon I, Reiner Robert C. Jr.

    LANCET GLOBAL HEALTH   Vol. 8 ( 9 ) page: E1162 - E1185   2020.9

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  116. Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17 Reviewed International coauthorship

    Aniruddha Deshpande, Molly K. Miller-Petrie, Paulina A. Lindstedt, Mathew M. Baumann, Kimberly B. Johnson, Brigette F. Blacker, Hedayat Abbastabar, Foad Abd-Allah, Ahmed Abdelalim, Ibrahim Abdollahpour, Kedir Hussein Abegaz, Ayenew Negesse Abejie, Lucas Guimaraes Abreu, Michael R. M. Abrigo, Ahmed Abualhasan, Manfred Mario Kokou Accrombessi, Abdu A. Adamu, Oladimeji M. Adebayo, Isaac Akinkunmi Adedeji, Rufus Adesoji Adedoyin, Victor Adekanmbi, Olatunji O. Adetokunboh, Tara Ballav Adhikari, Mohsen Afarideh, Marcela Agudelo-Botero, Mehdi Ahmadi, Keivan Ahmadi, Muktar Beshir Ahmed, Anwar E. Ahmed, Temesgen Yihunie Akalu, Ali S. Akanda, Fares Alahdab, Ziyad Al-Aly, Samiah Alam, Noore Alam, Genet Melak Alamene, Turki M. Alanzi, James Albright, Ammar Albujeer, Jacqueline Elizabeth Alcalde-Rabanal, Animut Alebel, Zewdie Aderaw Alemu, Muhammad Ali, Mehran Alijanzadeh, Vahid Alipour, Syed Mohamed Aljunid, Ali Almasi, Amir Almasi-Hashiani, Hesham M. Al-Mekhlafi, Khalid A. Altirkawi, Nelson Alvis-Guzman, Nelson J. Alvis-Zakzuk, Saeed Amini, Arianna Maever L. Amit, Gianna Gayle Herrera Amul, Catalina Liliana Andrei, Mina Anjomshoa, Ansariadi Ansariadi, Carl Abelardo T. Antonio, Benny Antony, Ernoiz Antriyandarti, Jalal Arabloo, Hany Mohamed Amin Aref, Olatunde Aremu, Bahram Armoon, Amit Arora, Krishna K. Aryal, Afsaneh Arzani, Mehran Asadi-Aliabadi, Daniel Asmelash, Hagos Tasew Atalay, Seyyede Masoume Athari, Seyyed Shamsadin Athari, Sachin R. Atre, Marcel Ausloos, Shally Awasthi, Nefsu Awoke, Beatriz Paulina Ayala Quintanilla, Getinet Ayano, Martin Amogre Ayanore, Yared Asmare Aynalem, Samad Azari, Andrew S. Azman, Ebrahim Babaee, Alaa Badawi, Mojtaba Bagherzadeh, Shankar M. Bakkannavar, Senthilkumar Balakrishnan, Maciej Banach, Joseph Adel Mattar Banoub, Aleksandra Barac, Miguel A. Barboza, Till Winfried Barnighausen, Sanjay Basu, Vo Dinh Bay, Mohsen Bayati, Neeraj Bedi, Mahya Beheshti, Meysam Behzadifar, Masoud Behzadifar, Diana Fernanda Bejarano Ramirez, Michelle L. Bell, Derrick A. Bennett, Habib Benzian, Dessalegn Ajema Berbada, Robert S. Bernstein, Anusha Ganapati Bhat, Krittika Bhattacharyya, Soumyadeep Bhaumik, Zulfiqar A. Bhutta, Ali Bijani, Boris Bikbov, Muhammad Shahdaat Bin Sayeed, Raaj Kishore Biswas, Somayeh Bohlouli, Soufiane Boufous, Oliver J. Brady, Andrey Nikolaevich Briko, Nikolay Ivanovich Briko, Gabrielle B. Britton, Alexandria Brown, Sharath Burugina Nagaraja, Zahid A. Butt, Luis Alberto Camera, Ismael R. Campos-Nonato, Julio Cesar Campuzano Rincon, Jorge Cano, Josip Car, Rosario Cardenas, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Ester Cerin, Binaya Chalise, Vijay Kumar Chattu, Ken Lee Chin, Devasahayam J. Christopher, Dinh-Toi Chu, Natalie Maria Cormier, Vera Marisa Costa, Elizabeth A. Cromwell, Abel Fekadu Fekadu Dadi, Tukur Dahiru, Saad M. A. Dahlawi, Rakhi Dandona, Lalit Dandona, Anh Kim Dang, Farah Daoud, Aso Mohammad Darwesh, Amira Hamed Darwish, Ahmad Daryani, Jai K. Das, Rajat Das Gupta, Aditya Prasad Dash, Claudio Alberto Davila-Cervantes, Nicole Davis Weaver, Fernando Pio De la Hoz, Jan-Walter De Neve, Dereje Bayissa Demissie, Gebre Teklemariam Demoz, Edgar Denova-Gutierrez, Kebede Deribe, Assefa Desalew, Samath Dhamminda Dharmaratne, Preeti Dhillon, Meghnath Dhimal, Govinda Prasad Dhungana, Daniel Diaz, Isaac Oluwafemi Dipeolu, Hoa Thi, Christiane Dolecek, Kerrie E. Doyle, Eleonora Dubljanin, Andre Rodrigues Duraes, Hisham Atan Edinur, Andem Effiong, Aziz Eftekhari, Nevine El Nahas, Maysaa El Sayed Zaki, Maha El Tantawi, Hala Rashad Elhabashy, Shaimaa El-Jaafary, Ziad El-Khatib, Hajer Elkout, Aisha Elsharkawy, Shymaa Enany, Daniel Adane Endalew, Babak Eshrati, Sharareh Eskandarieh, Arash Etemadi, Oluchi Ezekannagha, Emerito Jose A. Faraon, Mohammad Fareed, Andre Faro, Farshad Farzadfar, Alebachew Fasil Fasil, Mehdi Fazlzadeh, Valery L. Feigin, Wubalem Fekadu, Netsanet Fentahun, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Irina Filip, Florian Fischer, Carsten Flohr, Nataliya A. Foigt, Morenike Oluwatoyin Folayan, Masoud Foroutan, Richard Charles Franklin, Joseph Jon Frostad, Takeshi Fukumoto, Mohamed M. Gad, Gregory M. Garcia, Augustine Mwangi Gatotoh, Reta Tsegaye Gayesa, Ketema Bizuwork Gebremedhin, Yilma Chisha Dea Geramo, Hailay Abrha Gesesew, Kebede Embaye Gezae, Ahmad Ghashghaee, Farzaneh Ghazi Sherbaf, Tiffany K. Gill, Paramjit Singh Gill, Themba G. Ginindza, Alem Girmay, Zemichael Gizaw, Amador Goodridge, Sameer Vali Gopalani, Barbara Niegia Garcia Goulart, Alessandra C. Goulart, Ayman Grada, Manfred S. Green, Mohammed Ibrahim Mohialdeen Gubari, Harish Chander Gugnani, Davide Guido, Rafael Alves Guimaraes, Yuming Guo, Rajeev Gupta, Rahul Gupta, Giang Hai Ha, Juanita A. Haagsma, Nima Hafezi-Nejad, Dessalegn H. Haile, Michael Tamene Haile, Brian J. Hall, Samer Hamidi, Demelash Woldeyohannes Handiso, Hamidreza Haririan, Ninuk Hariyani, Ahmed Hasaballah, Mehedi Hasan, Amir Hasanzadeh, Hamid Yimam Hassen, Desta Haftu Hayelom, Mohamed Hegazy, Behzad Heibati, Behnam Heidari, Delia Hendrie, Andualem Henok, Claudiu Herteliu, Fatemeh Heydarpour, Hagos Degefa de Hidru, Thomas R. Hird, Chi Linh Hoang, Gillian Hollerich, Praveen Hoogar, Naznin Hossain, Mehdi Hosseinzadeh, Mowafa Househ, Guoqing Hu, Ayesha Humayun, Syed Ather Hussain, Mamusha Aman A. Hussen, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Milena D. Ilic, Mohammad Hasan Imani-Nasab, Usman Iqbal, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Rebecca Q. Ivers, Chinwe Juliana Iwu, Nader Jahanmehr, Mihajlo Jakovljevic, Amir Jalali, Achala Upendra Jayatilleke, Ensiyeh Jenabi, Ravi Prakash Jha, Vivekanand Jha, John S. Ji, Jost B. Jonas, Jacek Jerzy Jozwiak, Ali Kabir, Zubair Kabir, Tanuj Kanchan, Andre Karch, Surendra Karki, Amir Kasaeian, Gebremicheal Gebreslassie Kasahun, Habtamu Kebebe Kasaye, Gebrehiwot G. Kassa, Getachew Mullu Kassa, Gbenga A. Kayode, Mihiretu M. Kebede, Peter Njenga Keiyoro, Daniel Bekele Ketema, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Nauman Khalid, Rovshan Khalilov, Ejaz Ahmad Khan, Junaid Khan, Nuruzzaman Khan, Khaled Khatab, Mona M. Khater, Amir M. Khater, Maryam Khayamzadeh, Mohammad Khazaei, Mohammad Hossein Khosravi, Jagdish Khubchandani, Ali Kiadaliri, Yun Jin Kim, Ruth W. Kimokoti, Sezer Kisa, Adnan Kisa, Sonali Kochhar, Tufa Kolola, Hamidreza Komaki, Soewarta Kosen, Parvaiz A. Koul, Ai Koyanagi, Kewal Krishan, Barthelemy Kuate Defo, Nuworza Kugbey, Pushpendra Kumar, G. Anil Kumar, Manasi Kumar, Dian Kusuma, Carlo La Vecchia, Ben Lacey, Aparna Lal, Dharmesh Kumar Lal, Hilton Lam, Faris Hasan Lami, Van Charles Lansingh, Savita Lasrado, Georgy Lebedev, Paul H. Lee, Kate E. LeGrand, Mostafa Leili, Tsegaye Lolaso Lenjebo, Cheru Tesema Leshargie, Aubrey J. Levine, Sonia Lewycka, Shanshan Li, Shai Linn, Shiwei Liu, Jaifred Christian F. Lopez, Platon D. Lopukhov, Muhammed Magdy Abd El Razek, D. R. Mahadeshwara Prasad, Phetole Walter Mahasha, Narayan B. Mahotra, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Abdullah A. Mamun, Navid Manafi, Mohammad Ali Mansournia, Chabila Christopher Mapoma, Gabriel Martinez, Santi Martini, Francisco Rogerlandio Martins-Melo, Manu Raj Mathur, Benjamin K. Mayala, Mohsen Mazidi, Colm McAlinden, Birhanu Geta Meharie, Man Mohan Mehndiratta, Entezar Mehrabi Nasab, Kala M. Mehta, Teferi Mekonnen, Tefera Chane Mekonnen, Gebrekiros Gebremichael Meles, Hagazi Gebre Meles, Peter T. N. Memiah, Ziad A. Memish, Walter Mendoza, Ritesh G. Menezes, Seid Tiku Mereta, Tuomo J. Meretoja, Tomislav Mestrovic, Workua Mekonnen Metekiya, Bartosz Miazgowski, Ted R. Miller, G. K. Mini, Erkin M. Mirrakhimov, Babak Moazen, Bahram Mohajer, Yousef Mohammad, Dara K. Mohammad, Naser Mohammad Gholi Mezerji, Roghayeh Mohammadibakhsh, Shafiu Mohammed, Jemal Abdu Mohammed, Hassen Mohammed, Farnam Mohebi, Ali H. Mokdad, Yoshan Moodley, Masoud Moradi, Ghobad Moradi, Mohammad Moradi-Joo, Paula Moraga, Linda Morales, Abbas Mosapour, Jonathan F. Mosser, Simin Mouodi, Seyyed Meysam Mousavi, Miliva Mozaffor, Sandra B. Munro, Moses K. Muriithi, Christopher J. L. Murray, Kamarul Imran Musa, Ghulam Mustafa, Saravanan Muthupandian, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Mohsen Naghavi, Gurudatta Naik, Vinay Nangia, Bruno Ramos Nascimento, Javad Nazari, Duduzile Edith Ndwandwe, Ionut Negoi, Henok Biresaw Netsere, Josephine W. Ngunjiri, Cuong Tat Nguyen, Huong Lan Thi Nguyen, QuynhAnh P. Nguyen, Solomon Gedlu Nigatu, Dina Nur Anggraini Ningrum, Chukwudi A. Nnaji, Marzieh Nojomi, Ole F. Norheim, Jean Jacques Noubiap, Bogdan Oancea, Felix Akpojene Ogbo, In-Hwan Oh, Andrew T. Olagunju, Jacob Olusegun Olusanya, Bolajoko Olubukunola Olusanya, Obinna E. Onwujekwe, Doris Ortega-Altamirano, Osayomwanbo Osarenotor, Frank B. Osei, Mayowa O. Owolabi, P. A. Mahesh, Jagadish Rao Padubidri, Smita Pakhale, Adrian Pana, Eun-Kee Park, Sangram Kishor Patel, Ashish Pathak, Ajay Patle, Kebreab Paulos, Veincent Christian Filipino Pepito, Norberto Perico, Aslam Pervaiz, Julia Moreira Pescarini, Konrad Pesudovs, Hai Quang Pham, David M. Pigott, Thomas Pilgrim, Meghdad Pirsaheb, Mario Poljak, Ian Pollock, Maarten J. Postma, Farshad Pourmalek, Akram Pourshams, Sergio Prada, Liliana Preotescu, Hedley Quintana, Navid Rabiee, Mohammad Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Siavash Rahimi, Vafa Rahimi-Movaghar, Muhammad Aziz Rahman, Mohammad Hifz Ur Rahman, Fatemeh Rajati, Chhabi Lal Ranabhat, Puja C. Rao, Davide Rasella, Goura Kishor Rath, Salman Rawaf, Lal Rawal, Wasiq Faraz Rawasia, Giuseppe Remuzzi, Vishnu Renjith, Andre M. N. Renzaho, Serge Resnikoff, Seyed Mohammad Riahi, Ana Isabel Ribeiro, Jennifer Rickard, Leonardo Roever, Luca Ronfani, Enrico Rubagotti, Salvatore Rubino, Anas M. Saad, Siamak Sabour, Ehsan Sadeghi, Sahar Saeedi Moghaddam, Yahya Safari, Rajesh Sagar, Mohammad Ali Sahraian, S. Mohammad Sajadi, Mohammad Reza Salahshoor, Nasir Salam, Ahsan Saleem, Hosni Salem, Marwa Rashad Salem, Yahya Salimi, Hamideh Salimzadeh, Abdallah M. Samy, Juan Sanabria, Itamar S. Santos, Milena M. Santric-Milicevic, Bruno Piassi Sao Jose, Sivan Yegnanarayana Iyer Saraswathy, Nizal Sarrafzadegan, Benn Sartorius, Brijesh Sathian, Thirunavukkarasu Sathish, Maheswar Satpathy, Monika Sawhney, Mehdi Sayyah, Alyssa N. Sbarra, Lauren E. Schaeffer, David C. Schwebel, Anbissa Muleta Senbeta, Subramanian Senthilkumaran, Sadaf G. Sepanlou, Edson Servan-Mori, Azadeh Shafieesabet, Amira A. Shaheen, Izza Shahid, Masood Ali Shaikh, Ali S. Shalash, Mehran Shams-Beyranvand, MohammadBagher Shamsi, Morteza Shamsizadeh, Mohammed Shannawaz, Kiomars Sharafi, Rajesh Sharma, Aziz Sheikh, B. Suresh Kumar Shetty, Wondimeneh Shibabaw Shiferaw, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Reza Shirkoohi, K. M. Shivakumar, Si Si, Soraya Siabani, Tariq Jamal Siddiqi, Diego Augusto Santos Silva, Virendra Singh, Narinder Pal Singh, Balbir Bagicha Singh Singh, Jasvinder A. Singh, Ambrish Singh, Dhirendra Narain Sinha, Malede Mequanent Sisay, Eirini Skiadaresi, David L. Smith, Adauto Martins Soares Filho, Mohammad Reza Sobhiyeh, Anton Sokhan, Joan B. Soriano, Muluken Bekele Sorrie, Ireneous N. Soyiri, Emma Elizabeth Spurlock, Chandrashekhar T. Sreeramareddy, Agus Sudaryanto, Mu'awiyyah Babale Sufiyan, Hafiz Ansar Rasul Suleria, Bryan L. Sykes, Rafael Tabares-Seisdedos, Takahiro Tabuchi, Degena Bahrey Tadesse, Ingan Ukur Tarigan, Bineyam Taye, Yonatal Mesfin Tefera, Arash Tehrani-Banihashemi, Shishay Wahdey Tekelemedhin, Merhawi Gebremedhin Tekle, Mohamad-Hani Temsah, Berhe Etsay Tesfay, Fisaha Haile Tesfay, Zemenu Tadesse Tessema, Kavumpurathu Raman Thankappan, Akhil Soman ThekkePurakkal, Nihal Thomas, Robert L. Thompson, Alan J. Thomson, Roman Topor-Madry, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Khanh Bao Tran, Irfan Ullah, Bhaskaran Unnikrishnan, Muhammad Shariq Usman, Olalekan A. Uthman, Benjamin S. Chudi Uzochukwu, Pascual R. Valdez, Santosh Varughese, Yousef Veisani, Francesco S. Violante, Sebastian Vollmer, Feleke Gebremeskel Whawariat, Yasir Waheed, Mitchell Taylor Wallin, Yuan-Pang Wang, Yafeng Wang, Kinley Wangdi, Daniel J. Weiss, Girmay Teklay Weldesamuel, Adhena Ayaliew Werkneh, Ronny Westerman, Taweewat Wiangkham, Kirsten E. Wiens, Tissa Wijeratne, Charles Shey Wiysonge, Haileab Fekadu Wolde, Dawit Zewdu Wondafrash, Tewodros Eshete Wonde, Getasew Taddesse Worku, Ali Yadollahpour, Seyed Hossein Yahyazadeh Jabbari, Tomohide Yamada, Mehdi Yaseri, Hiroshi Yatsuya, Alex Yeshaneh, Mekdes Tigistu Yilma, Paul Yip, Engida Yisma, Naohiro Yonemoto, Mustafa Z. Younis, Hebat-Allah Salah A. Yousof, Chuanhua Yu, Hasan Yusefzadeh, Siddhesh Zadey, Telma Zahirian Moghadam, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Hamed Zandian, Heather J. Zar, Taddese Alemu Zerfu, Yunquan Zhang, Arash Ziapour, Sanjay Zodpey, Yves Miel H. Zuniga, Simon Hay, Robert C. Reiner

    LANCET GLOBAL HEALTH   Vol. 8 ( 9 ) page: E1162 - E1185   2020.9

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    Background Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities.Methods We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs.Findings Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40.0% (95% uncertainty interval [UI] 39.4-40.7) to 50.3% (50.0-50.5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46.3% (95% UI 46.1-46.5) in 2017, compared with 28.7% (28.5-29.0) in 2000. Although some units improved access to the safest drinking water or sanitation facilities since 2000, a large absolute number of people continued to not have access in several units with high access to such facilities (>80%) in 2017. More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88.6% (95% UI 87.2-89.7) access overall. Many units were able to transition from the least safe facilities in 2000 to safe facilities by 2017; for units in which populations primarily practised open defecation in 2000, 686 (95% UI 664-711) of the 1830 (1797-1863) units transitioned to the use of improved sanitation. Geographical disparities in access to improved water across units decreased in 76.1% (95% UI 71.6-80.7) of countries from 2000 to 2017, and in 53.9% (50.6-59.6) of countries for access to improved sanitation, but remained evident subnationally in most countries in 2017.Interpretation Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.

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  117. Risk Factors of Infectious Complications After Endobronchial Ultrasound-Guided Transbronchial Biopsy. Reviewed International journal

    Tomohide Souma, Tomoyuki Minezawa, Hiroshi Yatsuya, Takuya Okamura, Kumiko Yamatsuta, Sayako Morikawa, Tomoya Horiguchi, Shingo Maeda, Yasuhiro Goto, Masamichi Hayashi, Sumito Isogai, Naoki Yamamoto, Masashi Kondo, Kazuyoshi Imaizumi

    Chest   Vol. 158 ( 2 ) page: 797 - 807   2020.8

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    BACKGROUND: Infectious complications after endobronchial ultrasound-guided transbronchial biopsy with a guide sheath (EBUS-GS-TBB) are serious in that they may delay or change scheduled subsequent therapy. The aim of this study was to identify risk factors for infection after EBUS-GS-TBB. RESEARCH QUESTION: What are the risk factors for infection after EBUS-GS-TBB? STUDY DESIGN AND METHODS: We retrospectively reviewed the medical records of 1,045 consecutive patients who had undergone EBUS-GS-TBB for peripheral lung lesions between January 2013 and December 2017 at Fujita Health University Hospital. We evaluated the following risk factors for infectious complications after EBUS-GS-TBB: relevant patient characteristics (age and comorbidities), lesion size, CT scan features of target lesion (intratumoral low-density areas [LDAs] and cavitation), stenosis of responsible bronchus observed by bronchoscopy, and laboratory data before EBUS-GS-TBB (WBC count and C-reactive protein concentration). RESULTS: Forty-seven of the study patients developed infectious complications (24 with pneumonia, 14 with intratumoral infection, three with lung abscess, three with pleuritis, and three with empyema), among whom the complication caused a delay in cancer treatment in 13 patients, cancellation of cancer treatment in seven patients, and death in three patients. Multivariate analysis showed that cavitation (P = .007), intratumoral LDAs (P < .001), and stenosis of responsible bronchus observed by bronchoscopy (P < .001) were significantly associated with infectious complications after EBUS-GS-TBB. Prophylactic antibiotics had been administered to 13 patients in the infection group. Propensity matched analysis could not show significant benefit of prophylactic antibiotics in preventing post-EBUS-GS-TBB infections. INTERPRETATION: Cavitation, LDAs for CT scan features of target lesions, and stenosis of responsible bronchus observed by bronchoscopy are risk factors of post-EBUS-GS-TBB infection. In the cohort, prophylactic antibiotics failed to prevent infectious complications.

    DOI: 10.1016/j.chest.2020.02.025

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  118. Glycated haemoglobin (HbA1c) as a reliable option for detecting diabetes among the urban poor population in Bangladesh. Reviewed International coauthorship International journal

    Chiang C, Aoyama A, Khalequzzaman M, Choudhury SR, Paul D, Rayna SE, Khan FA, Hirakawa Y, Iso H, Yatsuya H

    European journal of public health   Vol. 30 ( 4 ) page: 839 - 841   2020.8

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    Our previous epidemiological survey targeting urban slum dwellers in Bangladesh showed that the prevalence of diabetes defined by glycated haemoglobin (HbA1c) was higher than the national estimation, and higher in women than men. Subsequently, we conducted the oral glucose tolerance test (OGTT) and found that HbA1c values were consistent with the OGTT findings for detecting diabetes. Our findings indicated that HbA1c ≥6.5% was a rational cut-off, but the optimal HbA1c cut-off for this population might be lower than the internationally recommended threshold. Measuring HbA1c would be a reliable and feasible option for detecting diabetes among underprivileged population in developing countries.

    DOI: 10.1093/eurpub/cky275

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  119. Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000-17 Reviewed International coauthorship International journal

    Wiens Kirsten E., Lindstedt Paulina A., Blacker Brigette F., Johnson Kimberly B., Baumann Mathew M., Schaeffer Lauren E., Abbastabar Hedayat, Abd-Allah Foad, Abdelalim Ahmed, Abdollahpour Ibrahim, Abegaz Kedir Hussein, Abejie Ayenew Negesse, Abreu Lucas Guimaraes, Abrigo Michael R. M., Abualhasan Ahmed, Accrombessi Manfred Mario Kokou, Acharya Dilaram, Adabi Maryam, Adamu Abdu A., Adebayo Oladimeji M., Adedoyin Rufus Adesoji, Adekanmbi Victor, Adetokunboh Olatunji O., Adhena Beyene Meressa, Afarideh Mohsen, Ahmad Sohail, Ahmadi Keivan, Ahmed Anwar E., Ahmed Muktar Beshir, Ahmed Rushdia, Akalu Temesgen Yihunie, Alahdab Fares, Al-Aly Ziyad, Alam Noore, Alam Samiah, Alamene Genet Melak, Alanzi Turki M., Alcalde-Rabanal Jacqueline Elizabeth, Ali Beriwan Abdulqadir, Alijanzadeh Mehran, Alipour Vahid, Aljunid Syed Mohamed, Almasi Ali, Almasi-Hashiani Amir, Al-Mekhlafi Hesham M., Altirkawi Khalid A., Alvis-Guzman Nelson, Alvis-Zakzuk Nelson J., Amini Saeed, Amit Arianna Maever L., Andrei Catalina Liliana, Anjomshoa Mina, Anoushiravani Amir, Ansari Fereshteh, Antonio Carl Abelardo T., Antony Benny, Antriyandarti Ernoiz, Arabloo Jalal, Aref Hany Mohamed Amin, Aremu Olatunde, Armoon Bahram, Arora Amit, Aryal Krishna K., Arzani Afsaneh, Asadi-Aliabadi Mehran, Atalay Hagos Tasew, Athari Seyyed Shamsadin, Athari Seyyede Masoume, Atre Sachin R., Ausloos Marcel, Awoke Nefsu, Quintanilla Beatriz Paulina Ayala, Ayano Getinet, Ayanore Martin Amogre, Aynalem Yared Asmare, Azari Samad, Azzopardi Peter S., Babaee Ebrahim, Babalola Tesleem Kayode, Badawi Alaa, Bairwa Mohan, Bakkannavar Shankar M., Balakrishnan Senthilkumar, Bali Ayele Geleto, Banach Maciej, Banoub Joseph Adel Mattar, Barac Aleksandra, Barnighausen Till Winfried, Basaleem Huda, Basu Sanjay, Bay Vo Dinh, Bayati Mohsen, Baye Estifanos, Bedi Neeraj, Beheshti Mahya, Behzadifar Masoud, Behzadifar Meysam, Bekele Bayu Begashaw, Belayneh Yaschilal Muche, Bell Michelle L., Bennett Derrick A., Berbada Dessalegn Ajema, Bernstein Robert S., Bhat Anusha Ganapati, Bhattacharyya Krittika, Bhattarai Suraj, Bhaumik Soumyadeep, Bhutta Zulfiqar A., Bijani Ali, Bikbov Boris, Birihane Binyam Minuye, Biswas Raaj Kishore, Bohlouli Somayeh, Bojia Hunduma Amensisa, Boufous Soufiane, Brady Oliver J., Bragazzi Nicola Luigi, Briko Andrey Nikolaevich, Briko Nikolay Ivanovich, Britton Gabrielle B., Nagaraja Sharath Burugina, Busse Reinhard, Butt Zahid A., Camera Luis Alberto, Campos-Nonato Ismael R., Cano Jorge, Car Josip, Cardenas Rosario, Carvalho Felix, Castaneda-Orjuela Carlos A., Castro Franz, Chanie Wagaye Fentahun, Chatterjee Pranab, Chattu Vijay Kumar, Chichiabellu Tesfaye Yitna, Chin Ken Lee, Christopher Devasahayam J., Chu Dinh-Toi, Cormier Natalie Maria, Costa Vera Marisa, Culquichicon Carlos, Daba Matiwos Soboka, Damiani Giovanni, Dandona Lalit, Dandona Rakhi, Dang Anh Kim, Darwesh Aso Mohammad, Darwish Amira Hamed, Daryani Ahmad, Das Jai K., Das Gupta Rajat, Dash Aditya Prasad, Davey Gail, Davila-Cervantes Claudio Alberto, Davis Adrian C., Davitoiu Dragos Virgil, De la Hoz Fernando Pio, Demis Asmamaw Bizuneh, Demissie Dereje Bayissa, Demissie Getu Debalkie, Demoz Gebre Teklemariam, Demoz Gebre Teklemariam, Denova-Gutierrez Edgar, Deribe Kebede, Desalew Assefa, Deshpande Aniruddha, Dharmaratne Samath Dhamminda, Dhillon Preeti, Dhimal Meghnath, Dhungana Govinda Prasad, Diaz Daniel, Dipeolu Isaac Oluwafemi, Djalalinia Shirin, Doyle Kerrie E., Dubljanin Eleonora, Duko Bereket, Duraes Andre Rodrigues, Kalan Mohammad Ebrahimi, Edinur Hisham Atan, Effiong Andem, Eftekhari Aziz, El Nahas Nevine, El Sayed Iman, Zaki Maysaa El Sayed, El Tantawi Maha, Elema Teshome Bekele, Elhabashy Hala Rashad, El-Jaafary Shaimaa I., Elkout Hajer, Elsharkawy Aisha, Elyazar Iqbal R. F., Endalamaw Aklilu, Endalew Daniel Adane, Eskandarieh Sharareh, Esteghamati Alireza, Esteghamati Sadaf, Etemadi Arash, Ezekannagha Oluchi, Fareed Mohammad, Faridnia Roghiyeh, Farzadfar Farshad, Fazlzadeh Mehdi, Feigin Valery L., Fereshtehnejad Seyed-Mohammad, Fernandes Eduarda, Filip Irina, Fischer Florian, Foigt Nataliya A., Folayan Morenike Oluwatoyin, Foroutan Masoud, Franklin Richard Charles, Fukumoto Takeshi, Gad Mohamed M., Gayesa Reta Tsegaye, Gebre Teshome, Gebremedhin Ketema Bizuwork, Gebremeskel Gebreamlak Gebremedhn, Gesesew Hailay Abrha, Gezae Kebede Embaye, Ghadiri Keyghobad, Ghashghaee Ahmad, Ghimire Pramesh Raj, Gill Paramjit Singh, Gill Tiffany K., Ginindza Themba G., Gomes Nelson G. M., Gopalani Sameer Vali, Goulart Alessandra C., Goulart Barbara Niegia Garcia, Grada Ayman, Gubari Mohammed Ibrahim Mohialdeen, Gugnani Harish Chander, Guido Davide, Guimaraes Rafael Alves, Guo Yuming, Gupta Rajeev, Hafezi-Nejad Nima, Haile Dessalegn H., Hailu Gessessew Bugssa, Haj-Mirzaian Arvin, Haj-Mirzaian Arya, Hamadeh Randah R., Hamidi Samer, Handiso Demelash Woldeyohannes, Haririan Hamidreza, Hariyani Ninuk, Hasaballah Ahmed I., Hasan Md Mehedi, Hasanpoor Edris, Hasanzadeh Amir, Hassankhani Hadi, Hassen Hamid Yimam, Hegazy Mohamed I., Heibati Behzad, Heidari Behnam, Hendrie Delia, Henry Nathaniel J., Herteliu Claudiu, Heydarpour Fatemeh, de Hidru Hagos Degefa, Hird Thomas R., Hoang Chi Linh, Rad Enayatollah Homaie, Hoogar Praveen, Hoseini Mohammad, Hossain Naznin, Hosseini Mostafa, Hosseinzadeh Mehdi, Househ Mowafa, Hsairi Mohamed, Hu Guoqing, Hussen Mohammedaman Mama, Ibitoye Segun Emmanuel, Igumbor Ehimario U., Ilesanmi Olayinka Stephen, Ilic Milena D., Imani-Nasab Mohammad Hasan, Iqbal Usman, Irvani Seyed Sina Naghibi, Islam Sheikh Mohammed Shariful, Iwu Chinwe Juliana, Izadi Neda, Jaca Anelisa, Jahanmehr Nader, Jakovljevic Mihajlo, Jalali Amir, Jayatilleke Achala Upendra, Jha Ravi Prakash, Jha Vivekanand, Ji John S., Jonas Jost B., Jozwiak Jacek Jerzy, Kabir Ali, Kabir Zubair, Kahsay Amaha, Kalani Hamed, Kanchan Tanuj, Matin Behzad Karami, Karch Andre, Karim Mohd Anisul, Karki Hamidreza Karimi-Sari Surendra, Kasaeian Amir, Kasahun Gebremicheal Gebreslassie, Kasahun Yawukal Chane, Kasaye Habtamu Kebebe, Kassa Gebrehiwot G., Kassa Getachew Mullu, Kayode Gbenga A., Karyani Ali Kazemi, Kebede Mihiretu M., Keiyoro Peter Njenga, Kelbore Abraham Getachew, Kengne Andre Pascal, Ketema Daniel Bekele, Khader Yousef Saleh, Khafaie Morteza Abdullatif, Khalid Nauman, Khalilov Rovshan, Khan Ejaz Ahmad, Khan Junaid, Khan Md Nuruzzaman, Khan Muhammad Shahzeb, Khatab Khaled, Khater Amir M., Khater Mona M., Khayamzadeh Maryam, Khazaei Mohammad, Khazaei Salman, Khosravi Mohammad Hossein, Khubchandani Jagdish, Kiadaliri Ali, Kim Yun Jin, Kimokoti Ruth W., Kisa Adnan, Kisa Sezer, Kissoon Niranjan, Shivakumar K. M., Kochhar Sonali, Kolola Tufa, Komaki Hamidreza, Kosen Soewarta, Koul Parvaiz A., Koyanagi Ai, Kraemer Moritz U. G., Krishan Kewal, Kugbey Nuworza, Kumar G. Anil, Kumar Manasi, Kumar Pushpendra, Kusuma Vivek Kumar Dian, La Vecchia Carlo, Lacey Ben, Lad Sheetal D., Lal Dharmesh Kumar, Lam Felix, Lami Faris Hasan, Lamichhane Prabhat, Lansingh Van Charles, Lasrado Savita, Laxmaiah Avula, Lee Paul H., LeGrand Kate E., Leili Mostafa, Lenjebo Tsegaye Lolaso, Leshargie Cheru Tesema, Levine Aubrey J., Li Shanshan, Linn Shai, Liu Shiwei, Liu Simin, Lodha Rakesh, Longbottom Joshua, Lopez Jaifred Christian F., Abd El Razek Hassan Magdy, Abd El Razek Muhammed Magdy, Prasad D. R. Mahadeshwara, Mahasha Phetole Walter, Mahotra Narayan B., Majeed Azeem, Malekzadeh Reza, Malta Deborah Carvalho, Mamun Abdullah A., Manafi Navid, Manda Ana Laura, Manohar Narendar Dawani Dawanu, Mansournia Mohammad Ali, Mapoma Chabila Christopher, Maravilla Joemer C., Martinez Gabriel, Martini Santi, Martins-Melo Francisco Rogerlandio, Masaka Anthony, Massenburg Benjamin Ballard, Mathur Manu Raj, Mayala Benjamin K., Mazidi Mohsen, McAlinden Colm, Meharie Birhanu Geta, Mehndiratta Man Mohan, Mehta Kala M., Mekonnen Tefera Chane, Meles Gebrekiros Gebremichael, Memiah Peter T. N., Memish Ziad A., Mendoza Walter, Menezes Ritesh G., Mereta Seid Tiku, Meretoja Tuomo J., Mestrovic Tomislav, Miazgowski Bartosz, Mihretie Kebadnew Mulatu, Miller Ted R., Mini G. K., Mirrakhimov Erkin M., Moazen Babak, Mohajer Bahram, Mohamadi-Bolbanabad Amjad, Mohammad Dara K., Mohammad Karzan Abdulmuhsin, Mohammad Yousef, Mezerji Naser Mohammad Gholi, Mohammadibakhsh Roghayeh, Mohammadifard Noushin, Mohammed Jemal Abdu, Mohammed Shafiu, Mohebi Farnam, Mokdad Ali H., Molokhia Mariam, Monasta Lorenzo, Moodley Yoshan, Moore Catrin E., Moradi Ghobad, Moradi Masoud, Moradi-Joo Mohammad, Moradi-Lakeh Maziar, Moraga Paula, Morales Linda, Velasquez Ilais Moreno, Mosapour Abbas, Mouodi Simin, Mousavi Seyyed Meysam, Mozaffor Miliva, Muchie Kindie Fentahun, Mulaw Getahun Fentaw, Munro Sandra B., Muriithi Moses K., Murray Christoper J. L., Murthy G. V. S., Musa Kamarul Imran, Mustafa Ghulam, Muthupandian Saravanan, Nabhan Ashraf F., Naderi Mehdi, Nagarajan Ahamarshan Jayaraman, Naidoo Kovin S., Naik Gurudatta, Najafi Farid, Nangia Vinay, Nansseu Jobert Richie, Nascimento Bruno Ramos, Nazari Javad, Ndwandwe Duduzile Edith, Negoi Ionut, Netsere Henok Biresaw, Ngunjiri Josephine W., Nguyen Cuong Tat, Nguyen Huong Lan Thi, Nguyen Trang Huyen, Nigatu Dabere, Nigatu Solomon Gedlu, Ningrum Dina Nur Anggraini, Nnaji Chukwudi A., Nojomi Marzieh, Nong Vuong Minh, Norheim Ole F., Noubiap Jean Jacques, Motlagh Soraya Nouraei, Oancea Bogdan, Ogah Okechukwu Samuel, Ogbo Felix Akpojene, Oh In-Hwan, Olagunju Andrew T., Olagunju Tinuke O., Olusanya Bolajoko Olubukunola, Olusanya Jacob Olusegun, Onwujekwe Obinna E., Oren Eyal, Ortega-Altamirano Doris V., Osarenotor Osayomwanbo, Osei Frank B., Owolabi Mayowa O., Mahesh P. A., Padubidri Jagadish Rao, Pakhale Smita, Patel Sangram Kishor, Paternina-Caicedo Angel J., Pathak Ashish, Patton George C., Paudel Deepak, Paulos Kebreab, Pepito Veincent Christian Filipino, Pereira Alexandre, Perico Norberto, Pervaiz Aslam, Pescarini Julia Moreira, Piroozi Bakhtiar, Pirsaheb Meghdad, Postma Maarten J., Pourjafar Hadi, Pourmalek Farshad, Pourshams Akram, Poustchi Hossein, Prada Sergio I., Prasad Narayan, Preotescu Liliana, Quintana Hedley, Rabiee Navid, Radfar Amir, Rafiei Alireza, Rahim Fakher, Rahimi-Movaghar Afarin, Rahimi-Movaghar Vafa, Rahman Mohammad Hifz Ur, Rahman Muhammad Aziz, Rahman Shafiur, Rajati Fatemeh, Rana Saleem Muhammad, Ranabhat Chhabi Lal, Rasella Davide, Rawaf David Laith, Rawaf Salman, Rawal Lal, Rawasia Wasiq Faraz, Renjith Vishnu, Renzaho Andre M. N., Resnikoff Serge, Reta Melese Abate, Rezaei Negar, Rezai Mohammad Sadegh, Riahi Seyed Mohammad, Ribeiro Ana Isabel, Rickard Jennifer, Rios-Blancas Maria, Roever Leonardo, Ronfani Luca, Roro Elias Merdassa, Ross Jennifer M., Rubagotti Enrico, Rubino Salvatore, Saad Anas M., Sabde Yogesh Damodar, Sabour Siamak, Sadeghi Ehsan, Safari Yahya, Safari-Faramani Roya, Sagar Rajesh, Sahebkar Amirhossein, Sahraian Mohammad Ali, Sajadi S. Mohammad, Salahshoor Mohammad Reza, Salam Nasir, Salamati Payman, Salem Hosni, Salem Marwa Rashad, Salimi Yahya, Salimzadeh Hamideh, Samy Abdallah M., Sanabria Juan, Santric-Milicevic Milena M., Jose Bruno Piassi Sao, Saraswathy Sivan Yegnanarayana Iyer, Sarkar Kaushik, Sarker Abdur Razzaque, Sarrafzadegan Nizal, Sartorius Benn, Sathian Brijesh, Sathish Thirunavukkarasu, Sawhney Monika, Saxena Sonia, Schwebel David C., Senbeta Anbissa Muleta, Senthilkumaran Subramanian, Sepanlou Sadaf G., Servan-Mori Edson, Shabaninejad Hosein, Shafieesabet Azadeh, Shaikh Masood Ali, Shalash Ali S., Shallo Seifadin Ahmed, Shams-Beyranvand Mehran, Shamsi MohammadBagher, Shamsizadeh Morteza, Shannawaz Mohammed, Sharafi Kiomars, Sharifi Hamid, Shehata Hatem Samir, Sheikh Aziz, Shetty B. Suresh Kumar, Shibuya Kenji, Shiferaw Wondimeneh Shibabaw, Shifti Desalegn Markos, Shigematsu Mika, Il Shin Jae, Shiri Rahman, Shirkoohi Reza, Siabani Soraya, Siddiqi Tariq Jamal, Silva Diego Augusto Santos, Singh Ambrish, Singh Jasvinder A., Singh Narinder Pal, Singh Virendra, Sisay Malede Mequanent, Skiadaresi Eirini, Sobhiyeh Mohammad Reza, Sokhan Anton, Soltani Shahin, Somayaji Ranjani, Soofi Moslem, Sorrie Muluken Bekele, Soyiri Ireneous N., Sreeramareddy Chandrashekhar T., Sudaryanto Agus, Sufiyan Mu'awiyyah Babale, Suleria Hafiz Ansar Rasul, Sultana Marufa, Sunguya Bruno Fokas, Sykes Bryan L., Tabares-Seisdedos Rafael, Tabuchi Takahiro, Tadesse Degena Bahrey, Tarigan Ingan Ukur, Tasew Aberash Abay, Tefera Yonatal Mesfin, Tekle Merhawi Gebremedhin, Temsah Mohamad-Hani, Tesfay Berhe Etsay, Tesfay Fisaha Haile, Tessema Belay, Tessema Zemenu Tadesse, Thankappan Kavumpurathu Raman, Thomas Nihal, Toma Alemayehu, Topor-Madry Roman, Tovani-Palone Marcos Roberto, Traini Eugenio, Tran Bach Xuan, Tran Khanh Bao, Ullah Irfan, Unnikrishnan Bhaskaran, Usman Muhammad Shariq, Uzochukwu Benjamin S. Chudi, Valdez Pascual R., Varughese Santosh, Violante Francesco S., Vollmer Sebastian, Hawariat Feleke Gebremeskel W., Waheed Yasir, Wallin Mitchell Taylor, Wang Yafeng, Wang Yuan-Pang, Weaver Marcia, Weji Bedilu Girma, Weldesamuel Girmay Teklay, Welgan Catherine A., Werdecker Andrea, Westerman Ronny, Wiangkham Taweewat, Wiysonge Charles Shey, Wolde Haileab Fekadu, Wondafrash Dawit Zewdu, Wonde Tewodros Eshete, Worku Getasew Taddesse, Wu Ai-Min, Xu Gelin, Yadollahpour Ali, Jabbari Seyed Hossein Yahyazadeh, Yamada Tomohide, Yatsuya Hiroshi, Yeshaneh Alex, Yilgwan Christopher Sabo, Yilma Mekdes Tigistu, Yip Paul, Yisma Engida, Yonemoto Naohiro, Yoon Seok-Jun, Younis Mustafa Z., Yousefifard Mahmoud, Yousof Hebat-Allah Salah A., Yu Chuanhua, Yusefzadeh Hasan, Zadey Siddhesh, Zaidi Zoubida, Bin Zaman Sojib, Zamani Mohammad, Zandian Hamed, Zepro Nejimu Biza, Zerfu Taddese Alemu, Zhang Yunquan, Zhao Xiu-Ju George, Ziapour Arash, Zodpey Sanjay, Zuniga Yves Miel H., Hay Simon I., Reiner Robert C. Jr.

    LANCET GLOBAL HEALTH   Vol. 8 ( 8 ) page: 1038 - 1060   2020.8

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  120. 安全衛生担当労働者における加熱式タバコの利用状況 Reviewed

    厚生の指標   Vol. 67 ( 6 ) page: 23 - 28   2020.6

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    目的 職域では受動喫煙対策とともに喫煙労働者への禁煙指導が課題となっている。日本の職域における加熱式タバコの使用実態を報告した論文は少ない。本研究の目的は,職域における加熱式タバコの使用実態を把握し,喫煙対策の実施につながる知見を得ることである。方法 某労働災害防止団体の地方センターにおいて2019年4月〜6月末の3ヵ月間に開催した安全衛生教育受講者(819人)を対象にした自記式質問紙調査を実施した。喫煙率,加熱式タバコ利用状況,年齢,性別,役職,企業規模,喫煙習慣との関連を調べた。回答者741人のうち,男性回答者で分析に必要な項目に欠損がなかった653人を解析した。結果 喫煙率は37.8%(247人)であった。現喫煙者割合は40〜49歳で高く(40.1%),過去喫煙者割合は50歳以上で高く(37.8%),非喫煙者割合は40歳未満で高かった(49.1%)(p<0.001)。役職,企業規模と現喫煙,過去喫煙,非喫煙の割合に有意な関連は認めなかった。現喫煙者247人の内,加熱式タバコのみを利用する者が67人(現喫煙者の27.1%),加熱式タバコと通常のタバコとの併用者が55人(現喫煙者の22.3%)であった。加熱式タバコの利用状況(加熱式のみ,併用,通常のタバコのみ)と年齢,役職,企業規模との間に統計学的に有意な関連は認めなかった。加熱式タバコの利用理由は「においが少ない」(67.2%),「煙が少ない」(47.5%),「火の心配が少ない」(43.4%),「自分の健康被害が少ないと思う」(35.2%),「周囲の健康被害が少ないと思う」(34.4%)であった。結論 男性労働者の喫煙率には年齢による差はあったが,企業規模や役職による差はなかった。男性労働者の加熱式タバコの利用は20%程度で,全喫煙者の約半分であった。本研究では,健康被害よりもにおいや火に関連した危険を理由として加熱式タバコを利用する者が多かった。事業場においては,通常のタバコへの喫煙対策と併せて加熱式タバコへの対策も行うことが望まれる

  121. Habitual tub bathing and risks of incident coronary heart disease and stroke. Reviewed International journal

    Tomohiko Ukai, Hiroyasu Iso, Kazumasa Yamagishi, Isao Saito, Yoshihiro Kokubo, Hiroshi Yatsuya, Isao Muraki, Ehab S Eshak, Norie Sawada, Shoichiro Tsugane

    Heart (British Cardiac Society)   Vol. 106 ( 10 ) page: 732 - 737   2020.5

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    OBJECTIVE: Tub bathing is considered to have a preventive effect against cardiovascular disease (CVD) by improving haemodynamic function. However, no prospective studies have investigated the long-term effects of tub bathing with regard to CVD risk. METHODS: A total of 30 076 participants aged 40-59 years with no history of CVD or cancer were followed up from 1990 to 2009. Participants were classified by bathing frequency: zero to two times/week, three to four times/week and almost every day. The HRs of incident CVD were estimated using Cox proportional hazards models after adjusting for traditional CVD risk factors and selected dietary factors. RESULTS: During 538 373 person-years of follow-up, we documented a total of 2097 incident cases of CVD, comprising 328 coronary heart diseases (CHDs) (275 myocardial infarctions and 53 sudden cardiac deaths) and 1769 strokes (991 cerebral infarctions, 510 intracerebral haemorrhages, 255 subarachnoid haemorrhages and 13 unclassified strokes). The multivariable HRs (95% CIs) for almost daily or every day versus zero to two times/week were 0.72 (0.62 to 0.84, trend p<0.001) for total CVD; 0.65 (0.45 to 0.94, trend p=0.065) for CHD; 0.74 (0.62 to 0.87, trend p=0.005) for total stroke; 0.77 (0.62 to 0.97, trend p=0.467) for cerebral infarction; and 0.54 (0.40 to 0.73, trend p<0.001) for intracerebral haemorrhage. No associations were observed between tub bathing frequency and risk of sudden cardiac death or subarachnoid haemorrhage. CONCLUSION: The frequency of tub bathing was inversely associated with the risk of CVD among middle-aged Japanese.

    DOI: 10.1136/heartjnl-2019-315752

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  122. ウルソデオキシコール酸添加による高脂肪食誘導性肝炎・線維化の軽減作用

    内藤 久雄, 北森 一哉, 橋本 沙幸, 浅野 友美, 八谷 寛, 那須 民江

    産業衛生学雑誌   Vol. 62 ( 臨増 ) page: 610 - 610   2020.5

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  123. 降圧薬ヒドララジンは高脂肪食摂取した高血圧ラットの肝線維化を抑制する

    内藤 久雄, 袁 媛, 北森 一哉, 橋本 沙幸, 浅野 友美, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 75 ( Suppl. ) page: S161 - S161   2020.3

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  124. 労働者の生活習慣指導のありかた 特定健康診査による保健指導レベルと2型糖尿病発症の関連およびその人口寄与危険割合 愛知職域コホート研究

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 内藤 久雄, 太田 充彦, 玉腰 浩司, 青山 温子

    産業衛生学雑誌   Vol. 62 ( 2 ) page: 94 - 94   2020.3

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  125. トリクロロエチレン曝露によるCYP2E1抗体の上昇とその影響因子

    那須 民江, 王 海蘭, 袁 媛, 内藤 久雄, 伊藤 由起, 柳場 由絵, 八谷 寛, 上島 通浩

    産業衛生学雑誌   Vol. 62 ( 2 ) page: 105 - 105   2020.3

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  126. Human herpesvirus-6B infection in pediatric allogenic hematopoietic stem cell transplant patients: Risk factors and encephalitis. Reviewed International journal

    Hiroki Miura, Yoshiki Kawamura, Fumihiko Hattori, Makito Tanaka, Kazuko Kudo, Masaru Ihira, Hiroshi Yatsuya, Yoshiyuki Takahashi, Seiji Kojima, Hirotoshi Sakaguchi, Nao Yoshida, Asahito Hama, Tetsushi Yoshikawa

    Transplant infectious disease : an official journal of the Transplantation Society   Vol. 22 ( 1 ) page: e13203   2020.2

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    BACKGROUND: Human herpesvirus-6B (HHV-6B) infection after allogenic hematopoietic stem cell transplantation (allo-HSCT) is known to be associated with post-transplant limbic encephalitis in adults. Meanwhile, the association between HHV-6B infection and central nervous system complications remains unclear in pediatric allo-HSCT patients. METHODS: In this study, HHV-6B infection was monitored for more than 50 days after HSCT using virus isolation and real-time PCR. Clinical information such as patient background and encephalitis status was collected retrospectively from medical records. Risk factors for HHV-6B infection were determined by the Cox proportional hazards model, and the clinical features of HHV-6B encephalitis in pediatric allo-HSCT patients were elucidated. RESULTS: Human herpesvirus-6B infection was observed in 74 (33.8%) of 219 patients at 3-47 days (median 18, interquartile range 13-20). Risk factors identified in multivariable analysis were hematological malignancy (hazards ratio [HR], 5.0; 95% confidence interval [CI], 2.3/12.5; P < .0001), solid tumor (HR, 4.8; CI, 1.5/16.3; P = .0104), unrelated donor (HR, 2.1; CI, 1.0/4.6; P = .0378), and sex-mismatched donor (HR 1.8; CI, 1.1/3.0; P = .0257). HHV-6B encephalitis occurred in only one of the 219 patients (0.46%); this patient demonstrated the typical clinical course of posterior reversible encephalopathy syndrome. CONCLUSION: Hematological malignancy, solid tumor, unrelated donor, and sex-mismatched donor were significant risk factors for HHV-6B infection after pediatric allo-HSCT. In pediatric allo-HSCT patients, the incidence of HHV-6B encephalitis was low and the clinical features differed from those in adult patients.

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  127. Association of Vegetable, Fruit, and Okinawan Vegetable Consumption With Incident Stroke and Coronary Heart Disease. Reviewed

    Takahiro Yoshizaki, Junko Ishihara, Ayaka Kotemori, Junpei Yamamoto, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Kazumasa Yamagishi, Norie Sawada, Motoki Iwasaki, Hiroyasu Iso, Shoichiro Tsugane

    Journal of epidemiology   Vol. 30 ( 1 ) page: 37 - 45   2020.1

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    BACKGROUND: Few studies have investigated the effects of Okinawan vegetable consumption on the risk of incident stroke and coronary heart disease. This study aimed to examine associations of vegetable, fruit, and Okinawan vegetable consumption with risk of incident stroke and coronary heart disease in the Japanese population of Okinawa. METHODS: The study design was a prospective cohort study. During 1995-1998, a validated food frequency questionnaire was administered in two study areas to 16,498 participants aged 45-74 years. In 217,467 person-years of follow-up until the end of 2012, a total of 839 stroke cases and 197 coronary heart disease cases were identified. RESULTS: No statistically significant association between total Okinawan vegetable consumption and risk of stroke and coronary heart disease was obtained: the multivariable adjusted hazard ratios for the highest versus lowest tertile of consumption were 1.09 (95% confidence interval, 0.93-1.29; P for trend = 0.289) in model 2. Total vegetable and fruit and specific Okinawan vegetable consumption were also not statistically significantly associated with risk of cardiovascular outcomes. CONCLUSIONS: This study demonstrated that consumption of total vegetable and fruit, total Okinawan vegetables, and specific Okinawan vegetables in Japanese residents of Okinawa was not associated with risk of incident stroke and coronary heart disease.

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  128. Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease: The Japan Public Health Center-Based Prospective (JPHC) Study. Reviewed

    Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

    Journal of atherosclerosis and thrombosis   Vol. 27 ( 4 ) page: 363 - 374   2020

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    AIM: A positive association between non-high-density lipoprotein cholesterol (non-HDL-C) and coronary heart disease (CHD) has been established; however, associations between non-HDL-C and stroke subtypes have not been determined. METHODS: We conducted a prospective study of 30,554 individuals aged 40-69 yrs with no history of cardiovascular disease (CVD) in Japan. Sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of stroke subtypes and CHD were estimated according to quintiles of non-HDL-C, using Cox proportional hazard models adjusted for other established risk factors. RESULTS: We identified 1,705 stroke and 296 CHD events over a median 15 yrs of follow-up. The fractional polynomials analysis revealed a U-shaped association between non-HDL-C and stroke risk in men. When analyzed for stroke subtypes, the data revealed an inverse relationship between non-HDL-C and intracerebral hemorrhage (ICH), primarily with lobar ICH, and a positive association between non-HDL-C and large-artery occlusive infarction in men [adjusted HR 0.55 (95% CI, 0.35-0.87) and 2.05 (95% CI, 1.07-3.93) for the highest and lowest quintile of non-HDL-C, respectively]. The lowest risk of ICH in women was observed in the fourth quintile, and the lowest risk of embolic infarction was observed in the third quintile. In contrast, non-HDL-C was positively associated with CHD in both sexes. CONCLUSIONS: In Japanese men, lower non-HDL-C levels were associated with a decreased risk of large-artery occlusive infarction and an increased risk of ICH, particularly lobar ICH.

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  129. Depressive Tendency and the Risk of Death from Pneumonia: The JACC Study. Reviewed

    Naohito Tanabe, Nao Seki, Chika Horikawa, Hiroshi Yatsuya, Kazumasa Yamagishi, Hiroyasu Iso, Shigekazu Ukawa, Akiko Tamakoshi

    Internal medicine (Tokyo, Japan)   Vol. 59 ( 24 ) page: 3123 - 3130   2020

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    Objective The burden of death from pneumonia is expected to increase with the aging of the population, as has been observed in Japan. Depressive tendency, a common psychosocial sign, may be a risk factor for pneumonia due to its possible association with some immune dysfunction. This study aimed to clarify the association between depressive tendency and the risk of death from pneumonia. Methods A population-based cohort that consisted of 75,174 Japanese men and women was followed for a median of 19.1 years. Four psychological and behavioral symptoms (depressive symptoms) were used to evaluate depressive tendency. Results A total of 1,329 deaths from pneumonia were observed. Depressive symptoms were positively and dose-dependently associated with the risk of death from pneumonia (P<0.001 for trend), and subjects with ≥2 depressive symptoms showed a significantly elevated risk compared to those without any symptoms (multivariable hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.39-1.99). This association was not significantly affected by sex or age at baseline. The elevated risk was still significant even when subjects were limited to those without any medical histories. The excess risk was observed not only for death occurring within the first 10 years of follow-up (multivariable HR, 2.05; 95% CI, 1.51-2.78) but also for that occurring in the longer follow-up period (multivariable HR, 1.48; 95% CI, 1.18-1.85). Conclusion Depressive tendency may be a risk factor for death from pneumonia. Further studies using a more reliable tool for the evaluation of depressive state are necessary to confirm this relationship.

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  130. Cross-sectional association between working and depression prevalence in cancer survivors: a literature review Reviewed International journal

    Atsuhiko Ota, Kenji Kawada, Akizumi Tsutsumi, Hiroshi Yatsuya

    Environmental and Occupational Health Practice   Vol. 2 ( 1 ) page: n/a - n/a   2020

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  131. Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies. Reviewed

    Atsushi Hozawa, Takumi Hirata, Hiroshi Yatsuya, Yoshitaka Murakami, Shinichi Kuriyama, Ichiro Tsuji, Daisuke Sugiyama, Atsushi Satoh, Sachiko Tanaka-Mizuno, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura

    Journal of epidemiology   Vol. 29 ( 12 ) page: 457 - 463   2019.12

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    BACKGROUND: We sought to investigate the optimal values of BMI for the lowest risk of all-cause death and whether the optimal BMI differs according to smoking status in large-scale pooled analysis of 13 Japanese cohorts. METHODS: Data from 179,987 participants of 13 well-qualified cohort studies conducted throughout Japan were used for our analysis. A cohort-stratified Cox proportional hazard model was used. P values for interactions were calculated based on the cross product of BMI and age, sex, or smoking status. RESULTS: In the entire study population, all-cause mortality risk was lowest when the BMI was 22.0-24.9 kg/m2. This was also the case for selected healthy participants (never smoked, baseline total cholesterol level ≥4.1 mmol/L; the first 5 years of follow-up data were excluded). No effect modification of age, sex, or smoking status was observed. Regardless of their BMI, never smokers always had a lower all-cause mortality risk than did current smokers even with an ideal BMI in terms of mortality risk. CONCLUSION: A BMI of 22-24.9 kg/m2 correlated with the lowest risk of mortality, regardless of whether all participants or selected healthy participants were analyzed. The fact that smoking was more strongly associated with mortality than obesity emphasizes the urgency for effective anti-smoking programs.

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  132. Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study. Reviewed International journal

    Utako Murai, Kazumasa Yamagishi, Mizuki Sata, Yoshihiro Kokubo, Isao Saito, Hiroshi Yatsuya, Junko Ishihara, Manami Inoue, Norie Sawada, Hiroyasu Iso, Shoichiro Tsugane

    The American journal of clinical nutrition   Vol. 110 ( 6 ) page: 1449 - 1455   2019.12

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    BACKGROUND: The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established. OBJECTIVES: We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population. METHODS: We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40-69 y). Seaweed intake was determined by FFQ at baseline (1990-1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95% CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors. RESULTS: During 1,493,232 person-years of follow-up, 4777 strokes (2863 ischemic stroke, 1361 intraparenchymal hemorrhages, and 531 subarachnoid hemorrhages) and 1204 ischemic heart disease cases were identified. Among men, significant multivariable HRs (95% CIs) for almost daily consumption compared with almost no consumption of seaweed were seen in ischemic heart disease [0.76 (0.58, 0.99); P-trend = 0.04] and total cardiovascular diseases [0.88 (0.78, 1.00); P-trend = 0.08]. Among women, such inverse associations were 0.56 (0.36, 0.85; P-trend = 0.006) for ischemic heart disease and 0.89 (0.76, 1.05; P-trend = 0.10) for total cardiovascular diseases. No significant associations were observed between seaweed intake and risk of total stroke or stroke types among either men or women. CONCLUSIONS: Seaweed intake was inversely associated with risk of ischemic heart disease.

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  133. Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies. Reviewed

    Shigehisa Kajikawa, Naoyuki Imai, Shotaro Okachi, Hiroshi Yatsuya, Tomohide Souma, Toshikazu Watanabe, Yasuhiro Goto, Tomoyuki Minezawa, Naozumi Hashimoto, Kazuyoshi Imaizumi, Yoshinori Hasegawa

    Nagoya journal of medical science   Vol. 81 ( 4 ) page: 613 - 620   2019.11

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    Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUS-GS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3%, CTBB: 66.0%). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1% (17/137), compared with only 4.1% (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7% (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.

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  134. Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes. Reviewed International coauthorship International journal

    Crystal Man Ying Lee, Stephen Colagiuri, Mark Woodward, Edward W Gregg, Robert Adams, Fereidoun Azizi, Rafael Gabriel, Tiffany K Gill, Clicerio Gonzalez, Allison Hodge, David R Jacobs Jr Jr, Joshua J Joseph, Davood Khalili, Dianna J Magliano, Kirsten Mehlig, Roger Milne, Gita Mishra, Morgana Mongraw-Chaffin, Julie A Pasco, Masaru Sakurai, Pamela J Schreiner, Elizabeth Selvin, Jonathan E Shaw, Gary Wittert, Hiroshi Yatsuya, Rachel R Huxley

    BMJ open diabetes research & care   Vol. 7 ( 1 ) page: e000794   2019.10

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    Objective: There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful. Research design and methods: We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease Collaboration. Cox regression models were used to obtain study-specific HRs for incident diabetes associated with each prediabetes definition. Harrell's C-statistics were used to estimate how well each prediabetes definition discriminated 5-year risk of diabetes. Spline and receiver operating characteristic curve (ROC) analyses were used to identify alternative cut-points. Results: Sixteen studies, with 76 513 participants and 8208 incident diabetes cases, were available. Compared with normoglycemia, current prediabetes definitions were associated with four to eight times higher diabetes risk (HRs (95% CIs): 3.78 (3.11 to 4.60) to 8.36 (4.88 to 14.33)) and all definitions discriminated 5-year diabetes risk with good accuracy (C-statistics 0.79-0.81). Cut-points identified through spline analysis were fasting plasma glucose (FPG) 5.1 mmol/L and glycated hemoglobin (HbA1c) 5.0% (31 mmol/mol) and cut-points identified through ROC analysis were FPG 5.6 mmol/L, 2-hour postload glucose 7.0 mmol/L and HbA1c 5.6% (38 mmol/mol). Conclusions: In terms of identifying individuals at greatest risk of developing diabetes within 5 years, using prediabetes definitions that have lower values produced non-significant gain. Therefore, deciding which definition to use will ultimately depend on the goal for identifying individuals at risk of diabetes.

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  135. Television Viewing Time and Breast Cancer Incidence or Japanese Premenopausal and Postmenopausal Women: The JACC Study Reviewed

    Cao Jinhong, Eshak Ehab Salah, Liu Keyang, Muraki Isar, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo, Kurozawa Yoichi

    CANCER RESEARCH AND TREATMENT   Vol. 51 ( 4 ) page: 1509 - 1517   2019.10

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  136. The association between weight fluctuation and all-cause mortality: A systematic review and meta-analysis. Reviewed International coauthorship International journal

    Yan Zhang, Fangfang Hou, Jiexue Li, Haiying Yu, Lu Li, Shilian Hu, Guodong Shen, Hiroshi Yatsuya

    Medicine   Vol. 98 ( 42 ) page: e17513   2019.10

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    BACKGROUND: Many observational studies have reported an association between weight fluctuation and all-cause mortality. However, the conclusions obtained from these studies have been unclear. OBJECTIVE: The current meta-analysis aimed to clarify the association between weight fluctuation and all-cause mortality. DATA SOURCE: We electronically searched PubMed, Embase, and Web of Science for articles reporting an association between weight fluctuation and all-cause mortality that were published before April 30, 2018. STUDY APPRAISAL AND SYNTHESIS METHODS: The methodological quality of each study was appraised using the modified Newcastle Ottawa Quality Assessment Scale. The hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were extracted from the included studies and pooled using random-effect models. Meta-regression approaches were also performed to explore sources of between-study heterogeneity. RESULTS: A total of 15 studies were eligible for the current meta-analysis. The pooled overall HR for all-cause mortality in the group with the greatest weight fluctuations compared with the most stable weight category was 1.45 (95% CI: 1.29-1.63). Considerable between-study heterogeneity was observed, some of which was partially explained by the different follow-up durations used by the included studies. Moreover, publication bias that inflated the risk of all-cause mortality was detected using Egger's test (P = .001). CONCLUSION: Weight fluctuation might be associated with an increased risk of all-cause mortality.

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  137. メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能 Reviewed

    金子 佳世, 八谷 寛, 李 媛英, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 青山 温子

    日本公衆衛生学会総会抄録集   Vol. 78回   page: 220 - 220   2019.10

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  138. メタボリックシンドローム、空腹時血糖、腹囲身長比による6年後の2型糖尿病発症予測能

    金子 佳世, 八谷 寛, 李 媛英, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 青山 温子

    日本公衆衛生学会総会抄録集   Vol. 78回   page: 220 - 220   2019.10

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  139. Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study. Reviewed International journal

    Li Y, Yatsuya H, Iso H, Yamagishi K, Saito I, Kokubo Y, Sawada N, Tsugane S

    Journal of epidemiology   Vol. 29 ( 9 ) page: 325 - 333   2019.9

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  140. Differences between expected and actual length of sick leave attributable to occupational accidents. Reviewed

    KATOH Yoshiji, OTA Atsuhiko, YATSUYA Hiroshi

    Journal of Occupational Safety and Health   Vol. 12 ( 3 ) page: 173 - 179   2019.9

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    <p>For prevention of occupational accidents, the Labor Standards Inspection Offices evaluated the severity of the accidents based on the expected length of sick leave which was reported to the offices. Workers who met the accidents often take longer periods of sick leave than expected. We examined the excess of the length and their associations with the workers' characteristics. The subjects were 1,672 workers (1,204 men and 468 women) who met occupational accidents. 71.2% of the men and 63.9% of the women took longer periods of sick leave than expected. Men had longer expected (median: 30 days for men, 28 days for women) and actual length of sick leave (median: 50 days for men, 39 days for women) than women. The median rates of the actual sick leave periods to the expected ones were 1.38 for the men and 1.20 for the women. In men, working for the transportation/port industry, a company size of 100-299 employees, and an age of less than 30, were significantly associated with taking longer periods of sick leave than expected. The severity of occupational accidents may be underestimated if it is estimated by the expected sick leave length.</p>

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  141. エチオピア北部の公務員における糖尿病および前糖尿病の危険因子(Risk factors of diabetes and prediabetes among public employees in northern Ethiopia) International coauthorship

    He Yupeng, Chiang Chifa, Gebremariam Lemlem W., Yatsuya Hiroshi, Hirakawa Yoshihisa, Aoyama Atsuko

    国際保健医療   Vol. 34 ( 3 ) page: 140 - 141   2019.9

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  142. High-fat and high-cholesterol diet decreases phosphorylated inositol-requiring kinase-1 and inhibits autophagy process in rat liver. Reviewed International journal

    Naito H, Yoshikawa-Bando Y, Yuan Y, Hashimoto S, Kitamori K, Yatsuya H, Nakajima T

    Scientific reports   Vol. 9 ( 1 ) page: 12514 - 12514   2019.8

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    Precise molecular pathways involved in the progression of non-alcoholic steatohepatitis (NASH) remain to be elucidated. As Mallory-Denk bodies were occasionally observed in the enlarged hepatocytes in NASH model rat (SHRSP5/Dmcr) fed high-fat and high-cholesterol (HFC) diet, we aimed to clarify the roles of autophagy and endoplasmic reticulum (ER) stress in NASH progression. Male SHRSP5/Dmcr were randomly divided into 4 groups. Two groups were fed a control diet; the other two groups were fed a HFC diet for 2 and 8 weeks, respectively. The HFC diet increased the autophagy-related proteins levels and microtubule-associated protein 1 light chain 3-II/I ratio after 2 and 8 weeks, respectively. However, regarding ER stress-related proteins, the HFC diet decreased the levels of phosphorylated (p-) inositol-requiring kinase-1 (p-IRE-1) and p-protein kinase RNA-like ER kinase after 2 weeks. Additionally, the HFC diet increased anti-ubiquitin-positive cells and the level of the autophagy substrate p62, suggesting that the HFC diet induced dysfunction in ubiquitin-dependent protein degradation pathways. In conclusion, the HFC diet arrested the autophagy process in the liver; this was particularly associated with decreases in p-IRE-1 expression.

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  143. Automated Feedback Messages With Shichifukujin Characters Using IoT System-Improved Glycemic Control in People With Diabetes: A Prospective, Multicenter Randomized Controlled Trial. Reviewed International journal

    Tomoko Kobayashi, Kazuyo Tsushita, Eri Nomura, Akiko Muramoto, Ayako Kato, Yukari Eguchi, Takeshi Onoue, Motomitsu Goto, Shigeki Muto, Hiroshi Yatsuya, Hiroshi Arima

    Journal of diabetes science and technology   Vol. 13 ( 4 ) page: 796 - 798   2019.7

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  144. Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study. Reviewed

    Shigekazu Ukawa, Wenjing Zhao, Hiroshi Yatsuya, Kazumasa Yamagishi, Naohito Tanabe, Hiroyasu Iso, Akiko Tamakoshi

    Journal of epidemiology   Vol. 29 ( 6 ) page: 233 - 237   2019.6

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    BACKGROUND: The association between daily walking and pneumonia mortality, stratified by the presence of disease conditions, such as myocardial infarction (MI) or stroke, was investigated. METHODS: The study participants were 22,280 Japanese individuals (9,067 men and 13,213 women) aged 65-79 years. Inverse propensity weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for pneumonia mortality. RESULTS: After a median of 11.9 years of follow-up, 1,203 participants died of pneumonia. Participants who did not have a history of MI or stroke and who walked for 1 hour/day or more were less likely to die from pneumonia (HR 0.90; 95% CI, 0.82-0.98) than those walked for 0.5 hours/day. A similar inverse association of pneumonia and walking (0.5 hours/day) was observed among participants with a history of MI (HR 0.66; 95% CI, 0.48-0.90). Among the participants with a history of stroke, those who walked for 0.6-0.9 hours/day were less likely to die because of pneumonia (HR 0.65; 95% CI, 0.43-0.98). CONCLUSIONS: Regular walking for ≥1 hour/day may reduce the risk of pneumonia mortality in elderly individuals with or without cardiovascular disease history.

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  145. Socioeconomic and lifestyle factors associated with depressive tendencies in general Japanese men and women: NIPPON DATA2010. Reviewed International journal

    Harumitsu Suzuki, Aya Kadota, Nagako Okuda, Takehito Hayakawa, Nobuo Nishi, Yasuyuki Nakamura, Hisatomi Arima, Naoko Miyagawa, Atsushi Satoh, Naomi Miyamatsu, Masahiko Yanagita, Hiroshi Yatsuya, Zentaro Yamagata, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

    Environmental health and preventive medicine   Vol. 24 ( 1 ) page: 37 - 37   2019.5

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    BACKGROUND: The gender-specific characteristics of individuals at an increased risk of developing depression currently remain unclear despite a higher prevalence of depression in women than in men. This study clarified socioeconomic and lifestyle factors associated with an increased risk of subclinical depression in general Japanese men and women. METHODS: Study participants were residents not receiving psychiatric treatments in 300 sites throughout Japan in 2010 (1152 men, 1529 women). Multivariable-adjusted odds ratios (OR) and 95% confidence intervals (95%CIs) for socioeconomic factors and lifestyle factors were calculated using a logistic regression analysis. RESULTS: Risk of depressive tendencies was significantly higher in men who were single and living alone (OR, 3.27; 95% CI, 1.56-6.88) than those married. The risk was significantly lower in women who were not working and aged ≥ 60 years (OR, 0.39; 95% CI, 0.22-0.68) and higher in men who were not working and aged < 60 years (OR, 3.57; 95%CI, 1.31-9.72) compared with those who were working. Current smoking was also associated with a significantly increased risk of depressive tendencies in women (OR, 2.96; 95% CI, 1.68-5.22) but not in men. CONCLUSIONS: Socioeconomic and lifestyle factors were associated with an increased risk of depressive tendencies in general Japanese. Related factors were different by sex.

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  146. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 Reviewed International coauthorship International journal

    Catherine Owens Johnson, Minh Nguyen, Gregory A. Roth, Emma Nichols, Tahiya Alam, Degu Abate, Foad Abd-Allah, Ahmed Abdelalim, Haftom Niguse Abraha, Niveen Me Abu-Rmeileh, Oladimeji M. Adebayo, Abiodun Moshood Adeoye, Gina Agarwal, Sutapa Agrawal, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Fares Alahdab, Raghib Ali, Nelson Alvis-Guzman, Nahla Hamed Anber, Mina Anjomshoa, Jalal Arabloo, Antonio Arauz, Johan Arnlov, Amit Arora, Ashish Awasthi, Maciej Banach, Miguel A. Barboza, Suzanne Lyn Barker-Collo, Till Winfried Barnighausen, Sanjay Basu, Abate Bekele Belachew, Yaschilal Muche Belayneh, Derrick A. Bennett, Isabela M. Bensenor, Krittika Bhattacharyya, Belete Biadgo, Ali Bijani, Boris Bikbov, Muhammad Shahdaat Bin Sayeed, Zahid A. Butt, Lucero Cahuana-Hurtado, Juan J. Carrero, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Ferran Catala-Lopez, Yazan Chaiah, Peggy Pei-Chia Chiang, Jee-Young J. Choi, Hanne Christensen, Dinh-Toi Chu, Monica Cortinovis, Albertino Antonio Moura Damasceno, Lalit Dandona, Rakhi Dandona, Ahmad Daryani, Kairat Davletov, Barbora De Courten, Vanessa De la Cruz-Gongora, Meaza Girma Degefa, Samath Dhamminda Dharmaratne, Daniel Diaz, Manisha Dubey, Eyasu Ejeta Duken, Dumessa Edessa, Matthias Endres, Emerito Jose A. Faraon, Farshad Farzadfar, Eduarda Fernandes, Florian Fischer, Luisa Sorio Flor, Morsaleh Ganji, Abadi Kahsu Gebre, Teklu Gebrehiwo Gebremichael, Birhanu Geta, Kebede Embaye Gezae, Paramjit Singh Gill, Elena V. Gnedovskaya, Hector Gomez-Dantes, Alessandra C. Goulart, Giuseppe Grosso, Yuming Guo, Rajeev Gupta, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Samer Hamidi, Graeme J. Hankey, Hamid Yimam Hassen, Simon I. Hay, Mohamed I. Hegazy, Behnam Heidari, Nabeel A. Herial, Mohammad Ali Hosseini, Sorin Hostiuc, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Nader Jahanmehr, Mehdi Javanbakht, Ravi Prakash Jha, Jost B. Jonas, Jacek Jerzy Jozwiak, Mikk Jurisson, Amaha Kahsay, Rizwan Kalani, Yogeshwar Kalkonde, Teshome Abegaz Kamil, Tanuj Kanchan, Andre Karch, Narges Karimi, Hamidreza Karimi-Sari, Amir Kasaeian, Tesfaye Dessale Kassa, Hossein Kazemeini, Adane Teshome Kefale, Yousef Saleh Khader, Ibrahim A. Khalil, Ejaz Ahmad Khan, Young-Ho Khang, Jagdish Khubchandani, Daniel Kim, Yun Jin Kim, Adnan Kisa, Mika Kivimaki, Ai Koyanagi, Rita K. Krishnamurthi, G. Anil Kumar, Alessandra Lafranconi, Sarah Lewington, Shanshan Li, Warren David Lo, Alan D. Lopez, Stefan Lorkowski, Paulo A. Lotufo, Mark T. Mackay, Marek Majdan, Reza Majdzadeh, Azeem Majeed, Reza Malekzadeh, Navid Manafi, Mohammad Ali Mansournia, Man Mohan Mehndiratta, Varshil Mehta, Getnet Mengistu, Atte Meretoja, Tuomo J. Meretoja, Bartosz Miazgowski, Tomasz Miazgowski, Ted R. Miller, Erkin M. Mirrakhimov, Bahram Mohajer, Yousef Mohammad, Milad Mohammadoo-Khorasani, Shafiu Mohammed, Farnam Mohebi, Ali H. Mokdad, Yaser Mokhayeri, Ghobad Moradi, Lidia Morawska, Ilais Moreno Velasquez, Seyyed Meysam Mousavi, Oumer Sada S. Muhammed, Walter Muruet, Mehdi Naderi, Mohsen Naghavi, Gurudatta Naik, Bruno Ramos Nascimento, Ruxandra Irina Negoi, Cuong Tat Nguyen, Long Hoang Nguyen, Yirga Legesse Nirayo, Bo Norrving, Jean Jacques Noubiap, Richard Ofori-Asenso, Felix Akpojene Ogbo, Andrew T. Olagunju, Tinuke O. Olagunju, Mayowa Ojo Owolabi, Jeyaraj Durai Pandian, Shanti Patel, Norberto Perico, Michael A. Piradov, Suzanne Polinder, Maarten J. Postma, Hossein Poustchi, V. Prakash, Mostafa Qorbani, Alireza Rafiei, Fakher Rahim, Kazem Rahimi, Vafa Rahimi-Movaghar, Mahfuzar Rahman, Muhammad Aziz Rahman, Cesar Reis, Giuseppe Remuzzi, Andre M. N. Renzaho, Stefano Ricci, Nicholas L. S. Roberts, Stephen R. Robinson, Leonardo Roever, Gholamreza Roshandel, Parisa Sabbagh, Hosein Safari, Saeed Safari, Saeid Safiri, Amirhossein Sahebkar, Saleh Salehi Zahabi, Abdallah M. Samy, Paola Santalucia, Itamar S. Santos, Joao Vasco Santos, Milena M. Santric Milicevic, Benn Sartorius, Arundhati R. Sawant, Aletta Elisabeth Schutte, Sadaf G. Sepanlou, Azadeh Shafieesabet, Masood Ali Shaikh, Mehran Shams-Beyranvand, Aziz Sheikh, Kevin N. Sheth, Kenji Shibuya, Mika Shigematsu, Min-Jeong Shin, Ivy Shiue, Soraya Siabani, Badr Hasan Sobaih, Luciano A. Sposato, Ipsita Sutradhar, P. A. Sylaja, Cassandra E. I. Szoeke, Braden James Te Ao, Mohamad-Hani Temsah, Omar Temsah, Amanda G. Thrift, Marcello Tonelli, Roman Topor-Madry, Bach Xuan Tran, Khanh Bao Tran, Thomas Clement Truelsen, Afewerki Gebremeskel Tsadik, Irfan Ullah, Olalekan A. Uthman, Muthiah Vaduganathan, Pascual R. Valdez, Tommi Juhani Vasankari, Rajagopalan Vasanthan, Narayanaswamy Venketasubramanian, Kia Vosoughi, Giang Thu Vu, Yasir Waheed, Elisabete Weiderpass, Kidu Gidey Weldegwergs, Ronny Westerman, Charles D. A. Wolfe, Dawit Zewdu Wondafrash, Gelin Xu, Ali Yadollahpour, Tomohide Yamada, Hiroshi Yatsuya, Ebrahim M. Yimer, Naohiro Yonemoto, Mahmoud Yousefifard, Chuanhua Yu, Zoubida Zaidi, Mohammad Zamani, Afshin Zarghi, Yunquan Zhang, Sanjay Zodpey, Valery L. Feigin, Theo Vos, Christopher J. L. Murray

    LANCET NEUROLOGY   Vol. 18 ( 5 ) page: 439 - 458   2019.5

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    Background Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016.Methods We report estimates and corresponding uncertainty intervals (UIs), from 1990 to 2016, for incidence, prevalence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). DALYs were generated by summing YLLs and YLDs. Cause-specific mortality was estimated using an ensemble modelling process with vital registration and verbal autopsy data as inputs. Non-fatal estimates were generated using Bayesian meta-regression incorporating data from registries, scientific literature, administrative records, and surveys. The Socio-demographic Index (SDI), a summary indicator generated using educational attainment, lagged distributed income, and total fertility rate, was used to group countries into quintiles.Findings In 2016, there were 5.5 million (95% UI 5.3 to 5.7) deaths and 116.4 million (111.4 to 121.4) DALYs due to stroke. The global age-standardised mortality rate decreased by 36.2% (-39.3 to -33.6) from 1990 to 2016, with decreases in all SDI quintiles. Over the same period, the global age-standardised DALY rate declined by 34.2% (-37.2 to -31.5), also with decreases in all SDI quintiles. There were 13.7 million (12.7 to 14.7) new stroke cases in 2016. Global age-standardised incidence declined by 8.1% (-10.7 to -5.5) from 1990 to 2016 and decreased in all SDI quintiles except the middle SDI group. There were 80.1 million (74.1 to 86.3) prevalent cases of stroke globally in 2016; 41.1 million (38.0 to 44.3) in women and 39.0 million (36.1 to 42.1) in men.Interpretation Although age-standardised mortality rates have decreased sharply from 1990 to 2016, the decrease in age-standardised incidence has been less steep, indicating that the burden of stroke is likely to remain high. Planned updates to future GBD iterations include generating separate estimates for subarachnoid haemorrhage and intracerebral haemorrhage, generating estimates of transient ischaemic attack, and including atrial fibrillation as a risk factor. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.

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  147. Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up. Reviewed

    Kayo Kaneko, Hiroshi Yatsuya, Yuanying Li, Mayu Uemura, Chifa Chiang, Yoshihisa Hirakawa, Atsuhiko Ota, Koji Tamakoshi, Atsuko Aoyama

    Journal of diabetes investigation   Vol. 10 ( 3 ) page: 837 - 845   2019.5

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    AIMS/INTRODUCTION: To prospectively investigate whether simultaneous elevation of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT) is associated with the increase of type 2 diabetes mellitus incidence independent of alcohol drinking, body mass index and triglycerides. METHODS: A total of 2,775 Japanese male workers who had no history of type 2 diabetes mellitus were followed. High GGT and ALT were defined as the top tertiles (GGT cutpoint: 49 IU/L, ALT cutpoint: 28 IU/L). Three groups were created using these dichotomized GGT and ALT cutpoints: both low, either high or both high. Multivariable Cox proportional hazards models were carried out adjusted for potential confounding factors. RESULTS: A total of 276 type 2 diabetes mellitus cases were identified during 12 years (27,040 person-years) of follow up. Participants with simultaneously elevated GGT and ALT had a significantly higher incidence of type 2 diabetes mellitus, even after adjustment for fasting insulin and fasting blood glucose compared with the group without GGT or ALT elevation. Similar associations were observed in non- or light-to-moderate alcohol drinkers, as well as in participants with normal weight. However, the association was weaker in participants with triglycerides <150 mg/dL. We then evaluated whether the addition of GGT and ALT would improve the prediction of type 2 diabetes mellitus incidence, and found that their inclusion significantly increased the C-statistic, net reclassification improvement and integrated discrimination improvement. CONCLUSIONS: Simultaneous elevation of GGT and ALT was significantly associated with type 2 diabetes mellitus incidence, independent of potential confounding factors, including alcohol drinking and obesity, although the association might require concomitant elevation of triglycerides. Inclusion of GGT and ALT improved type 2 diabetes mellitus risk prediction.

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  148. Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men - The Japan Public Health Center-Based Prospective Study Cohort II. Reviewed

    Rie Hayashi, Hiroyasu Iso, Kazumasa Yamagishi, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Ehab S Eshak, Norie Sawada, Shoichiro Tsugane

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 83 ( 5 ) page: 1072 - 1079   2019.5

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    BACKGROUND: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40-59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 person-years), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95% confidence interval [CI] 1.01-2.63) for acute myocardial infarction and 0.83 (95% CI 0.60-1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95% CI 1.03-4.35) and men aged 50-59 years (HR 2.60, 95% CI 1.42-4.77). CONCLUSIONS: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction.

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  149. 特定保健指導レベルと2型糖尿病発症の関連・その臨床疫学的指標 愛知職域コホート

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 内藤 久雄, 太田 充彦, 玉腰 浩司, 青山 温子

    産業衛生学雑誌   Vol. 61 ( 臨増 ) page: 321 - 321   2019.5

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  150. トリクロロエチレンによるCYP2E1抗体上昇とhypersensitivity syndromeとの関係

    那須 民江, 王 海蘭, 袁 媛, 内藤 久雄, 伊藤 由起, 八谷 寛, 上島 通浩

    産業衛生学雑誌   Vol. 61 ( 臨増 ) page: 332 - 332   2019.5

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  151. Recent Status and Methodological Quality of Return-to-Work Rates of Cancer Patients Reported in Japan: A Systematic Review. Reviewed International journal

    Ota A, Fujisawa A, Kawada K, Yatsuya H

    International journal of environmental research and public health   Vol. 16 ( 8 )   2019.4

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    Cancer patients' return-to-work rates in Japan and their methodological quality have been little reported. We conducted a systematic review to explore the recent return-to-work rates and to assess the methodological quality of the existing literature. We selected 13 papers (2 in English and 11 in Japanese) published between 2005 and 2017. The return-to-work rates ranged from 53.8% to 95.2%. Of the selected papers, 12 papers employed a cross-sectional design, possessing high risk of selection bias due to participant selection. A total of 8 papers did not fully report the subjects' sex, age, employment status at cancer diagnosis, cancer site, stage, and treatment, suggesting high risk of selection bias due to confounding variables. High or unclear risk of attrition bias due to incomplete outcome data was detected in 12 papers in which data on return to work were not collected from all participants. High risk of reporting bias due to selective outcome reporting was pointed out in 6 studies in which the subjects' employment status at return to work or the duration between cancer diagnosis and assessment of return to work was unclear. Future studies must reduce the risk of selection, attrition, and reporting biases for specifying accurate return-to-work rates.

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  152. Validation of the Japanese Version of the Yale Food Addiction Scale 2.0 (J-YFAS 2.0). Reviewed International coauthorship

    Khine MT, Ota A, Gearhardt AN, Fujisawa A, Morita M, Minagawa A, Li Y, Naito H, Yatsuya H

    Nutrients   Vol. 11 ( 3 ) page: 687 - 687   2019.3

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    The Yale Food Addiction Scale 2.0 (YFAS 2.0) is used for assessing food addiction (FA). Our study aimed at validating its Japanese version (J-YFAS 2.0). The subjects included 731 undergraduate students. Confirmatory factor analysis indicated the root-mean-square error of approximation, comparative fit index, Tucker–Lewis index, and standardized root-mean-square residual were 0.065, 0.904, 0.880, and 0.048, respectively, for a one-factor structure model. Kuder–Richardson α was 0.78. Prevalence of the J-YFAS 2.0-diagnosed mild, moderate, and severe FA was 1.1%, 1.2%, and 1.0%, respectively. High uncontrolled eating and emotional eating scores of the 18-item Three-Factor Eating Questionnaire (TFEQ R-18) (p &lt; 0.001), a high Kessler Psychological Distress Scale score (p &lt; 0.001), frequent desire to overeat (p = 0.007), and frequent snacking (p = 0.003) were associated with the J-YFAS 2.0-diagnosed FA presence. The scores demonstrated significant correlations with the J-YFAS 2.0-diagnosed FA symptom count (p &lt; 0.01). The highest attained body mass index was associated with the J-YFAS 2.0-diagnosed FA symptom count (p = 0.026). The TFEQ R-18 cognitive restraint score was associated with the J-YFAS 2.0-diagnosed FA presence (p &lt; 0.05) and symptom count (p &lt; 0.001), but not with the J-YFAS 2.0-diagnosed FA severity. Like the YFAS 2.0 in other languages, the J-YFAS 2.0 has a one-factor structure and adequate convergent validity and reliability.

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  153. Prevalence and Correlates of Dyslipidemia Among Men and Women in Palau: Findings of the Palau STEPS Survey 2011-2013. Reviewed International coauthorship

    Cui M, Chiang C, Cui R, Honjo K, Yatsuya H, Watson BM, Ikerdeu E, Mita T, Madraisau S, Aoyama A, Iso H

    Journal of epidemiology   Vol. 29 ( 3 ) page: 97 - 103   2019.3

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    BACKGROUND: Epidemiological evidence of dyslipidemia in Pacific Island countries is limited despite the knowledge that non-communicable diseases have a high burden in the region. We aimed to examine the prevalence and correlates of dyslipidemia among residents of Palau. METHODS: The Palau STEPwise approach to Surveillance (STEPS), which was conducted from 2011 through 2013, comprised three parts: behavioral risk factors; physical measurements; and biochemical tests, covering areas such as blood lipids. We used STEPS-generated data to perform a cross-sectional study of 2,184 randomly selected Palau residents, comprising Palauans and non-Palauans aged 25-64 years. RESULTS: The age-adjusted mean BMI was 29.3 kg/m2 in men and 29.9 kg/m2 in women; age-adjusted mean triglycerides value was 182 mg/dL in men and 166 mg/dL in women; and age-adjusted mean cholesterol was 178 mg/dL in men and 183 mg/dL in women. The prevalence of overweight/obesity (BMI ≥25 kg/m2) was 75% in men and 76% in women, and those of hypertriglyceridemia (triglycerides ≥150 mg/dL) and hypercholesterolemia (total cholesterol ≥200 mg/dL) were 48% in men and 41% in women and 18% in men and 23% in women, respectively. Mean values of total cholesterol were 177 mg/dL in Palauan men and 182 mg/dL in non-Palauan men. Mean values of triglycerides were 171 mg/dL in Palauan women and 150 mg/dL in non-Palauan women. Women living in rural areas showed a higher mean value of total cholesterol than those in urban areas. CONCLUSION: We found a high mean BMI and high prevalence of overweight/obesity and hypertriglyceridemia, but low mean total cholesterol and a low prevalence of hypercholesterolemia in Palau. Lipid profiles varied by age, ethnicity, and living area.

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  154. Multicenter feasibility study of bowel preparation with castor oil for colon capsule endoscopy. Reviewed International journal

    Ohmiya N, Hotta N, Mitsufuji S, Nakamura M, Omori T, Maeda K, Okuda K, Yatsuya H, Tajiri H

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   Vol. 31 ( 2 ) page: 164 - 172   2019.3

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    BACKGROUND AND AIM: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster. METHODS: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged. RESULTS: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (P < 0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; P = 0.0048), male gender (adjusted OR, 3.20; P = 0.0051), and use of castor oil (adjusted OR, 6.29; P = 0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (P = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (P = 0.0713). Per-examinee sensitivity for polyps ≥6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively. CONCLUSION: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.

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  155. Sleep duration and risk of breast cancer: The JACC Study Reviewed

    Cao Jinhong, Eshak Ehab S., Liu Keyang, Muraki Isao, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo

    BREAST CANCER RESEARCH AND TREATMENT   Vol. 174 ( 1 ) page: 219 - 225   2019.2

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  156. Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium Reviewed International coauthorship International journal

    Inker L.A, Grams M.E, Levey A.S, Coresh J, Cirillo M, Collins J.F, Gansevoort R.T, Gutierrez O.M, Hamano T, Heine G.H, Ishikawa S, Jee S.H, Kronenberg F, Landray M.J, Miura K, Nadkarni G.N, Peralta C.A, Rothenbacher D, Schaeffner E, Sedaghat S, Shlipak M.G, Zhang L, van Zuilen A.D, Hallan S.I, Kovesdy C.P, Woodward M, Levin A, Astor B, Appel L, Greene T, Chen T, Chalmers J, Arima H, Perkovic V, Yatsuya H, Tamakoshi K, Li Y, Hirakawa Y, Matsushita K, Sang Y, Polkinghorne K, Chadban S, Atkins R, Djurdjev O, Liu L, Zhao M, Wang F, Wang J, Ebert N, Martus P, Tang M, Emrich I, Seiler S, Zawada A, Nally J, Navaneethan S, Schold J, Sarnak M, Katz R, Hiramoto J, Iso H, Yamagishi K, Umesawa M, Muraki I, Fukagawa M, Maruyama S, Hasegawa T, Fujii N, Wheeler D, Emberson J, Townend J, Brenner H, Sch{\"o}ttker B, Saum K.-U, Fox C, Hwang S.-J, K{\"o}ttgen A, Schneider M.P, Eckardt K.-U, Green J, Kirchner H.L, Chang A.R, Ho K, Ito S, Miyazaki M, Nakayama M, Yamada G, Irie F, Sairenchi T, Yano Y, Kotani K, Nakamura T, Kimm H, Mok Y, Chodick G, Shalev V, Wetzels J.F.M, Blankestijn P.J, van den Brand J, Kollerits B, Ritz E, Nitsch D, Roderick P, Fletcher A, Bottinger E, Ellis S.B, Nadukuru R, Ueshima H, Okayama A, Tanaka S, Okamura T, Kadota A, Kenealy T, Elley C.R, Drury P.L, Ohkubo T, Asayama K, Metoki H, Kikuya M, Nelson R.G, Knowler W.C, Bakker S.J, Hak E, Heerspink H.J.L, Brunskill N, Major R, Shepherd D, Medcalf J, Jassal S.K, Bergstrom J, Ix J.H, Barrett-Connor E, Kalantar-Zadeh K, Sumida K, Muntner P, Warnock D, McClellan W, de Zeeuw D, Brenner B, Ikram M.A, Hoorn E.J, Dehghan A, Carrero J.J, Gasparini A, Wettermark B, Elinder C.-G, Wong T.Y, Sabanayagam C, Cheng C.-Y, Visseren F.L.J, Evans M, Segelmark M, Stendahl M, Sch{\"o}n S, Tangri N, Sud M, Naimark D, Wen C.-P, Tsao C.-K, Tsai M.-K, Chen C.-H, Konta T, Hirayama A, Ichikawa K, Lannfelt L, Larsson A, A}rnl{\"o}v J, Bilo H.J.G, Landman G.W.D, van Hateren K.J.J, Kleefstra N, Coresh (Chair J, Hallan S, Ballew S.H, Chen J, Kwak L, Surapaneni A

    American Journal of Kidney Diseases   Vol. 73 ( 2 ) page: 206 - 217   2019.2

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    © 2018 National Kidney Foundation, Inc. Rationale & Objective: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework. Study Design: Cross-sectional individual participant-level analyses in a global consortium. Setting & Study Populations: 17 CKD and 38 general population and high-risk cohorts. Selection Criteria for Studies: Cohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension. Data Extraction: Data were obtained and analyzed between July 2015 and January 2018. Analytical Approach: We modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses. Results: The CKD cohorts (n = 254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n = 1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59 mL/min/1.73 m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30 mg/g). Limitations: Variations in study era, health care delivery system, typical diet, and laboratory assays. Conclusions: Lower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.

    DOI: 10.1053/j.ajkd.2018.08.013

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    Other Link: http://orcid.org/0000-0002-3283-8196

  157. Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium Reviewed International coauthorship

    Chang, AR; Grams, ME; Ballew, SH; Bilo, H; Correa, A; Evans, M; Gutierrez, OM; Hosseinpanah, F; Iseki, K; Kenealy, T; Klein, B; Kronenberg, F; Lee, BJ; Li, YY; Miura, K; Navaneethan, SD; Roderick, PJ; Valdivielso, JM; Visseren, FLJ; Zhang, LX; Gansevoort, RT; Hallan, SI; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Astor, B; Appel, L; Greene; Chen, T; Chalmers, J; Woodward, M; Arima, H; Perkovic, V; Yatsuya, H; Tamakoshi, K; Li, Y; Hirakawa, Y; Coresh, J; Matsushita, K; Grams, M; Sang, Y; Polkinghorne, K; Chadban, S; Atkins, R; Levin, A; Djurdjev, O; Dam, B; Klein, R; Klein, B; Lee, K; Zhang, LX; Liu, LS; Zhao, MH; Wang, F; Wang, JW; Levin, A; Djurdjev, O; Tang, M; Heine, G; Emrich, I; Zawada, A; Bauer, L; Nally, J; Navaneethan, S; Schold, J; Zhang, LX; Zhao, MH; Wang, F; Wang, JW; Shlipak, M; Sarnak, M; Katz, R; Hiramoto, J; Iso, H; Yamagishi, K; Umesawa, M; Muraki, I; Fukagawa, M; Maruyama, S; Hamano, T; Hasegawa, T; Fujii, N; Jafar, T; Hatcher, J; Poulter, N; Chaturvedi, N; Wheeler, D; Emberson, J; Townend, J; Landray, M; Hermann; Brenner; Schöttker, B; Saum, KU; Rothenbacher, D; Fox, C; Hwang, SJ; Köttgen, A; Kronenberg, F; Schneider, MP; Eckardt, KU; Green, J; Kirchner, HL; Chang, AR; Ito, S; Miyazaki, M; Nakayama, M; Yamada, G; Cirillo, M; Hallan, S; Romundstad, S; Ovrehus, M; Langlo, KA; Irie, F; Sairenchi, T; Correa, A; Rebholz, CM; Young, B; Boulware, LE; Ishikawa, S; Yano, Y; Kotani, K; Nakamura, T; Jee, SH; Kimm, H; Mok, Y; Lee, BJ; Chodick, G; Shalev, V; Wetzels, JFM; Blankestijn, PJ; van Zuilen, AD; Bots, M; Sarnak, M; Inker, L; Shlipak, M; Sarnak, M; Katz, R; Peralta, C; Kronenberg, F; Kollerits, B; Ritz, E; Nitsch, D; Roderick, P; Fletcher, A; Bottinger, E; Nadkarni, GN; Ellis, SB; Nadukuru, R; Valdivielso, JM; Fernandez, E; Betriu, A; Bermudez-Lopez, M; Stengel, B; Metzger, M; Flamant, M; Houillier, P; Haymann, JP; Froissart, M; Sang, YY; Ueshima, H; Okayama, A; Miura, K; Tanaka, S; Ueshima, H; Okamura, T; Miura, K; Tanaka, S; Kenealy, T; Elley, CR; Collins, JF; Drury, PL; Ohkubo, T; Asayama, K; Metoki, H; Kikuya, M; Nakayama, M; Iseki, K; Iseki, C; Nelson, RG; Knowler, WC; Gansevoort, RT; Bakker, SJL; Heerspink, HJL; Brunskill, N; Major, R; Shepherd, D; Medcalf, J; Bernardo, R; Jassal, SK; Bergstrom, J; Joachim, H; Barrett-Connor, E; Kovesdy, C; Kalantar-Zadeh, K; Sumida, K; Muntner, P; Warnock, D; Judd, S; Panwar, B; Heerspink, HJL; de Zeeuw, D; Brenner, B; Sedaghat, S; Ikram, MA; Hoorn, EJ; Dehghan, A; Wong, TY; Sabanayagam, C; Cheng, CY; Binte, RB; Sokor, MA; Visseren, FLJ; Evans, M; Segelmark, M; Stendahl, M; Schön, S; Tangri, N; Sud, M; Naimark, D; Wen, CP; Tsao, K; Tsai, MK; Chen, CH; Konta, T; Hirayama, A; Ichikawa, K; Hosseinpanah, F; Hadaegh, F; Mirbolouk, M; Azizi, F; Solbu, MD; Jenssen, TG; Eriksen, BO; Eggen, AE; Lannfelt, L; Larsson, A; Ärnlöv, J; Bilo, HJG; Landman, GWD; Van Hateren, KJJ; Kleefstra, N; Coresh, J; Gansevoort, RT; Grams, ME; Hallan, S; Kovesdy, CP; Levey, AS; Matsushita, K; Shalev, V; Woodward, M; Ballew, SH; Chen, JS; Coresh, J; Grams, ME; Kwak, L; Matsushita, K; Sang, YY; Surapaneni, A; Woodward, M

    BMJ-BRITISH MEDICAL JOURNAL   Vol. 364   2019.1

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  158. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 Reviewed International coauthorship International journal

    Valery L. Feigin, Emma Nichols, Tahiya Alam, Marlena S. Bannick, Ettore Beghi, Natacha Blake, William J. Culpepper, E. Ray Dorsey, Alexis Elbaz, Richard G. Ellenbogen, James L. Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L. James, Catherine Owens Johnson, Nicholas J. Kassebaum, Giancarlo Logroscino, Benoit Marin, W. Cliff Mountjoy-Venning, Minh Nguyen, Richard Ofori-Asenso, Anoop P. Patel, Marco Piccininni, Gregory A. Roth, Timothy J. Steiner, Lars Jacob Stovner, Cassandra E. I. Szoeke, Alice Theadom, Stein Emil Vollset, Mitchell Taylor Wallin, Claire Wright, Joseph Raymond Zunt, Nooshin Abbasi, Foad Abd-Allah, Ahmed Abdelalim, Ibrahim Abdollahpour, Victor Aboyans, Haftom Niguse Abraha, Dilaram Acharya, Abdu A. Adamu, Oladimeji M. Adebayo, Abiodun Moshood Adeoye, Jose C. Adsuar, Mohsen Afarideh, Sutapa Agrawal, Alireza Ahmadi, Muktar Beshir Ahmed, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, Rufus Olusola Akinyemi, Nadia Akseer, Ayman Al-Eyadhy, Rustam Al-Shahi Salman, Fares Alahdab, Kefyalew Addis Alene, Syed Mohamed Aljunid, Khalid Altirkawi, Nelson Alvis-Guzman, Nahla Hamed Anber, Carl Abelardo T. Antonio, Jalal Arabloo, Olatunde Aremu, Johan Arnlov, Hamid Asayesh, Rana Jawad Asghar, Hagos Tasew Atalay, Ashish Awasthi, Beatriz Paulina Ayala Quintanilla, Tambe B. Ayuk, Alaa Badawi, Maciej Banach, Joseph Adel Mattar Banoub, Miguel A. Barboza, Suzanne Lyn Barker-Collo, Till Winfried Barnighausen, Bernhard T. Baune, Neeraj Bedi, Masoud Behzadifar, Meysam Behzadifar, Yannick Bejot, Bayu Begashaw Bekele, Abate Bekele Belachew, Derrick A. Bennett, Isabela M. Bensenor, Adugnaw Berhane, Mircea Beuran, Krittika Bhattacharyya, Zulfiqar A. Bhutta, Belete Biadgo, Ali Bijani, Nigus Bililign, Muhammad Shahdaat Bin Sayeed, Christopher Kynrint Blazes, Carol Brayne, Zahid A. Butt, Ismael R. Campos-Nonato, Carlos Cantu-Brito, Mate Car, Rosario Cardenas, Juan J. Carrero, Felix Carvalho, Carlos A. Castaneda-Orjuela, Franz Castro, Ferran Catala-Lopez, Ester Cerin, Yazan Chaiah, Jung-Chen Chang, Irini Chatziralli, Peggy Pei-Chia Chiang, Hanne Christensen, Devasahayam J. Christopher, Cyrus Cooper, Paolo Angelo Cortesi, Vera M. Costa, Michael H. Criqui, Christopher Stephen Crowe, Albertino Antonio Moura Damasceno, Ahmad Daryani, Vanessa De la Cruz-Gongora, Fernando Pio De la Hoz, Diego De Leo, Meaza Girma Degefa, Gebre Teklemariam Demoz, Kebede Deribe, Samath Dhamminda Dharmaratne, Daniel Diaz, Mesfin Tadese Dinberu, Shirin Djalalinia, David Teye Doku, Manisha Dubey, Eleonora Dubljanin, Eyasu Ejeta Duken, David Edvardsson, Ziad El-Khatib, Matthias Endres, Aman Yesuf Endries, Sharareh Eskandarieh, Alireza Esteghamati, Sadaf Esteghamati, Farzaneh Farhadi, Andre Faro, Farshad Farzadfar, Mohammad Hosein Farzaei, Batool Fatima, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Garumma Tolu Feyissa, Irina Filip, Florian Fischer, Takeshi Fukumoto, Morsaleh Ganji, Fortune Gbetoho Gankpe, Miguel A. Garcia-Gordillo, Abadi Kahsu Gebre, Teklu Gebrehiwo Gebremichael, Belayneh K. Gelaw, Johanna M. Geleijnse, Demeke Geremew, Kebede Embaye Gezae, Maryam Ghasemi-Kasman, Mahari Y. Gidey, Paramjit Singh Gill, Tiffany K. Gill, Elena V. Gnedovskaya, Alessandra C. Goulart, Ayman Grada, Giuseppe Grosso, Yuming Guo, Rahul Gupta, Rajeev Gupta, Juanita A. Haagsma, Tekleberhan B. Hagos, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Randah R. Hamadeh, Samer Hamidi, Graeme J. Hankey, Yuantao Hao, Josep Maria Haro, Hadi Hassankhani, Hamid Yimam Hassen, Rasmus Havmoeller, Simon I. Hay, Mohamed I. Hegazy, Behnam Heidari, Andualem Henok, Fatemeh Heydarpour, Chi Linh Hoang, Michael K. Hole, Enayatollah Homaie Rad, Seyed Mostafa Hosseini, Guoqing Hu, Ehimario U. Igumbor, Olayinka Stephen Ilesanmi, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Mihajlo Jakovljevic, Mehdi Javanbakht, Ravi Prakash Jha, Yash B. Jobanputra, Jost B. Jonas, Jacek Jerzy Jozwiak, Mikk Jurisson, Amaha Kahsay, Rizwan Kalani, Yogeshwar Kalkonde, Teshome Abegaz Kamil, Tanuj Kanchan, Manoochehr Karami, Andre Karch, Narges Karimi, Amir Kasaeian, Tesfaye Dessale Kassa, Zemenu Yohannes Kassa, Anil Kaul, Adane Teshome Kefale, Peter Njenga Keiyoro, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Ibrahim A. Khalil, Ejaz Ahmad Khan, Young-Ho Khang, Habibolah Khazaie, Aliasghar A. Kiadaliri, Daniel N. Kiirithio, Anthony S. Kim, Daniel Kim, Young-Eun Kim, Yun Jin Kim, Adnan Kisa, Yoshihiro Kokubo, Ai Koyanagi, Rita V. Krishnamurthi, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Manasi Kumar, Ben Lacey, Alessandra Lafranconi, Van C. Lansingh, Arman Latifi, Cheru Tesema Leshargie, Shanshan Li, Yu Liao, Shai Linn, Warren David Lo, Jaifred Christian F. Lopez, Stefan Lorkowski, Paulo A. Lotufo, Robyn M. Lucas, Raimundas Lunevicius, Mark T. Mackay, Narayan Bahadur Mahotra, Marek Majdan, Reza Majdzadeh, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Navid Manafi, Mohammad Ali Mansournia, Lorenzo Giovanni Mantovani, Winfried Marz, Tivani Phosa Mashamba-Thompson, Benjamin Ballard Massenburg, Kedar K. V. Mate, Colm McAlinden, John J. McGrath, Varshil Mehta, Toni Meier, Hagazi Gebre Meles, Addisu Melese, Peter T. N. Memiah, Ziad A. Memish, Walter Mendoza, Desalegn Tadese Mengistu, Getnet Mengistu, Atte Meretoja, Tuomo J. Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Tomasz Miazgowski, Ted R. Miller, G. K. Mini, Erkin M. Mirrakhimov, Babak Moazen, Bahram Mohajer, Naser Mohammad Gholi Mezerji, Moslem Mohammadi, Maryam Mohammadi-Khanaposhtani, Roghayeh Mohammadibakhsh, Mousa Mohammadnia-Afrouzi, Shafiu Mohammed, Farnam Mohebi, Ali H. Mokdad, Lorenzo Monasta, Stefania Mondello, Yoshan Moodley, Mahmood Moosazadeh, Ghobad Moradi, Maziar Moradi-Lakeh, Mehdi Moradinazar, Paula Moraga, Ilais Moreno Velasquez, Shane Douglas Morrison, Seyyed Meysam Mousavi, Oumer Sada Muhammed, Walter Muruet, Kamarul Imran Musa, Ghulam Mustafa, Mehdi Naderi, Gabriele Nagel, Aliya Naheed, Gurudatta Naik, Farid Najafi, Vinay Nangia, Ionut Negoi, Ruxandra Irina Negoi, Charles Richard James Newton, Josephine W. Ngunjiri, Cuong Tat Nguyen, Long Hoang Nguyen, Dina Nur Anggraini Ningrum, Yirga Legesse Nirayo, Molly R. Nixon, Bo Norrving, Jean Jacques Noubiap, Malihe Nourollahpour Shiadeh, Peter S. Nyasulu, Felix Akpojene Ogbo, In-Hwan Oh, Andrew T. Olagunju, Tinuke O. Olagunju, Pedro R. Olivares, Obinna E. Onwujekwe, Eyal Oren, Mayowa Ojo Owolabi, P. A. Mahesh, Amir H. Pakpour, Wen-Harn Pan, Songhomitra Panda-Jonas, Jeyaraj Durai Pandian, Sangram Kishor Patel, David M. Pereira, Max Petzold, Julian David Pillay, Michael A. Piradov, Guilherme V. Polanczyk, Suzanne Polinder, Maarten J. Postma, Richie Poulton, Hossein Poustchi, Swayam Prakash, V. Prakash, Mostafa Qorbani, Amir Radfar, Anwar Rafay, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Fatemeh Rajati, Usha Ram, Anna Ranta, David Laith Rawaf, Salman Rawaf, Nickolas Reinig, Cesar Reis, Andre M. N. Renzaho, Serge Resnikoff, Shahab Rezaeian, Mohammad Sadegh Rezai, Carlos Miguel Rios Gonzalez, Nicholas L. S. Roberts, Leonardo Roever, Luca Ronfani, Elias Merdassa Roro, Gholamreza Roshandel, Ali Rostami, Parisa Sabbagh, Ralph L. Sacco, Perminder S. Sachdev, Basema Saddik, Hosein Safari, Roya Safari-Faramani, Sare Safi, Saeid Safiri, Rajesh Sagar, Ramesh Sahathevan, Amirhossein Sahebkar, Mohammad Ali Sahraian, Payman Salamati, Saleh Salehi Zahabi, Yahya Salimi, Abdallah M. Samy, Juan Sanabria, Itamar S. Santos, Milena M. Santric Milicevic, Nizal Sarrafzadegan, Benn Sartorius, Shahabeddin Sarvi, Brijesh Sathian, Maheswar Satpathy, Arundhati R. Sawant, Monika Sawhney, Ione J. C. Schneider, Ben Schottker, David C. Schwebel, Soraya Seedat, Sadaf G. Sepanlou, Hosein Shabaninejad, Azadeh Shafieesabet, Masood Ali Shaikh, Raad A. Shakir, Mehran Shams-Beyranvand, Morteza Shamsizadeh, Mehdi Sharif, Mahdi Sharif-Alhoseini, Jun She, Aziz Sheikh, Kevin N. Sheth, Mika Shigematsu, Rahman Shiri, Reza Shirkoohi, Ivy Shiue, Soraya Siabani, Tariq J. Siddiqi, Inga Dora Sigfusdottir, Rannveig Sigurvinsdottir, Donald H. Silberberg, Joao Pedro Silva, Dayane Gabriele Alves Silveira, Jasvinder A. Singh, Dhirendra Narain Sinha, Eirini Skiadaresi, Mari Smith, Badr Hasan Sobaih, Soheila Sobhani, Moslem Soofi, Ireneous N. Soyiri, Luciano A. Sposato, Dan J. Stein, Murray B. Stein, Mark A. Stokes, Mu'awiyyah Babale Sufiyan, Bryan L. Sykes, Pn Sylaja, Rafael Tabares-Seisdedos, Braden James Te Ao, Arash Tehrani-Banihashemi, Mohamad-Hani Temsah, Omar Temsah, Jarnail Singh Thakur, Amanda G. Thrift, Roman Topor-Madry, Miguel Tortajada-Girbes, Marcos Roberto Tovani-Palone, Bach Xuan Tran, Khanh Bao Tran, Thomas Clement Truelsen, Afewerki Gebremeskel Tsadik, Lorainne Tudor Car, Kingsley Nnanna Ukwaja, Irfan Ullah, Muhammad Shariq Usman, Olalekan A. Uthman, Pascual R. Valdez, Tommi Juhani Vasankari, Rajagopalan Vasanthan, Yousef Veisani, Narayanaswamy Venketasubramanian, Francesco S. Violante, Vasily Vlassov, Kia Vosoughi, Giang Thu Vu, Isidora S. Vujcic, Fasil Shiferaw Wagnew, Yasir Waheed, Yuan-Pang Wang, Elisabete Weiderpass, Jordan Weiss, Harvey A. Whiteford, Tissa Wijeratne, Andrea Sylvia Winkler, Charles Shey Wiysonge, Charles D. A. Wolfe, Gelin Xu, Ali Yadollahpour, Tomohide Yamada, Yuichiro Yano, Mehdi Yaseri, Hiroshi Yatsuya, Ebrahim M. Yimer, Paul Yip, Engida Yisma, Naohiro Yonemoto, Mahmoud Yousefifard, Chuanhua Yu, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Hamed Zandian, Zohreh Zare, Yunquan Zhang, Sanjay Zodpey, Mohsen Naghavi, Christopher J. L. Murray, Theo Vos

    LANCET NEUROLOGY   Vol. 18 ( 1 ) page: 56 - 87   2019.1

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    Background Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247-308]) and second leading cause of deaths (9.0 million [8.8-9.4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34-44] and DALYs by 15% [9-21]) whereas their age-standardised rates decreased (deaths by 28% [26-30] and DALYs by 27% [24-31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42.2% [38.6-46.1]), migraine (16.3% [11.7-20.8]), Alzheimer's and other dementias (10.4% [9.0-124]), and meningitis (7.9% [6.6-10.4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1.12 [1.05-1.20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0.7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88.8% (86.5-90.9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22.3% [11.8-35.1] of DALYs are risk attributable) and idiopathic epilepsy (14.1% [10.8-17.5] of DALYs are risk attributable).Interpretation Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies. Copyright (C) The Author(s). Published by Elsevier Ltd.

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  159. Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan) Reviewed International journal

    Satoh Michihiro, Ohkubo Takayoshi, Asayama Kei, Murakami Yoshitaka, Sugiyama Daisuke, Yamada Michiko, Saitoh Shigeyuki, Sakata Kiyomi, Irie Fujiko, Sairenchi Toshimi, Ishikawa Shizukiyo, Kiyama Masahiko, Ohnishi Hirofumi, Miura Katsuyuki, Imai Yutaka, Ueshima Hirotsugu, Okamura Tomonori, Iso Hiroyasu, Kitamura Akihiko, Ninomiya Toshiharu, Kiyohara Yutaka, Nakagawa Hideaki, Nakayama Takeo, Okayama Akira, Sairenchi Toshimi, Tamakoshi Akiko, Tsuji Ichiro, Miyamoto Yoshihiro, Ishikawa Shizukiyo, Yatsuya Hiroshi, Okamura Tomonori

    HYPERTENSION   Vol. 73 ( 1 ) page: 52 - 59   2019.1

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    Lifetime risk (LTR) provides an absolute risk assessment during the remainder of one’s life. Few studies have focused on the LTRs of stroke and coronary heart disease (CHD), categorized by fine blood pressure in Asian populations. We aimed to assess it using a large database of a meta-analysis with the individual participant data. The present metaanalysis included 107 737 Japanese (42.4% men; mean age, 55.1 years) from 13 cohorts. During the mean follow-up of 15.2±5.3 years (1 559 136 person-years), 1922 died from stroke and 913 from CHD. We estimated risks after adjusting for competing risk of death other than the outcome of interest. The 10-year risk of stroke and CHD deaths at index age of 35 years was ≤1.9% and ≤0.3%, respectively. The LTRs of stroke death at the index age of 35 years (men/women) were 6.1%/4.8% for optimal, 5.7%/6.3% for normal, and 6.6%/6.0% for high-normal blood pressure groups, and 9.1%/7.9% for grade 1, 14.5%/10.3% for grade 2, and 14.6%/14.3% for grade 3 hypertension groups. The LTRs of CHD death similarly elevated with an increase in blood pressure but were lower (≤7.2%) than those of stroke death. In conclusion, blood pressure was clearly associated with an elevated LTR of stroke or CHD death, although the LTR of CHD death was one-half of that of stroke death in an Asian population. These results would help young people with hypertension to adopt a healthy lifestyle or start antihypertensive therapy early.

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  160. Smoking results in accumulation of ectopic fat in the liver. Reviewed International journal

    Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H

    Diabetes, metabolic syndrome and obesity : targets and therapy   Vol. 12   page: 1075 - 1079   2019

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    Objective: An association between smoking and nonalcoholic fatty liver disease has been reported. However, objective quantification of intrahepatic fat via magnetic resonance spectroscopy (MRS) in relation to smoking has rarely been performed in previous studies. Moreover, the possible pathways via which smoking could induce ectopic fat accumulation have not yet been addressed. The current study aimed to examine the association between smoking status and intrahepatic fat quantity and explore the possible mediating effects of triglycerides (TG) and adiponectin. Subjects and methods: Magnetic resonance imager (MRI) spectra were analyzed to quantify intrahepatic fat in 45 men who were on average 62.3 years of age. Smoking status and alcohol intake were self-reported. Accelerometers were used to record daily total physical activity. Fasting blood TG and adiponectin levels were measured enzymatically. Differences in mean intrahepatic fat values according to smoking status were assessed using analysis of covariance. Results: A stepwise increase in mean intrahepatic fat was observed between never, former, and current smokers, respectively, independent of age, physical activity, alcohol intake, and body mass index (BMI) (P=0.005). Adjustment for TG and adiponectin significantly attenuated this association (P=0.074). Conclusion: Current smoking was significantly associated with increased intrahepatic fat, which may be a result of adipocyte dysfunction, manifested as high circulating TG concentrations and low adiponectin levels.

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  161. Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study Reviewed

    Nishida Yoko, Kubota Yasuhiko, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Iso Hiroyasu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Ando Masahiko, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Fujino Yoshihisa, Shibata Akira

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   Vol. 26 ( 9 ) page: 775 - 782   2019

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    DOI: 10.5551/jat.46383

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  162. Smoking results in accumulation of ectopic fat in the liver. Reviewed

    Smoking results in accumulation of, ectopic fat in, the, liver, Kato A, Li Y, Ota A, Naito H, Yamada H, Nihashi T, Hotta Y, Chiang C, Hirakawa Y, Aoyama A, Tamakoshi K, Yatsuya H

    Diabetes Metab Syndr Obes   Vol. 9 ( 12 ) page: 1075 - 1080   2019

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  163. MULTICENTER FEASIBILITY STUDY OF BOWEL PREPARATION WITH CASTOR OIL FOR COLON CAPSULE ENDOSCOPY Reviewed International journal

    OHMIYA Naoki, HOTTA Naoki, MITSUFUJI Shoji, NAKAMURA Masanao, OMORI Takafumi, MAEDA Kohei, OKUDA Kotaro, YATSUYA Hiroshi, TAJIRI Hisao

    GASTROENTEROLOGICAL ENDOSCOPY   Vol. 61 ( 12 ) page: 2646 - 2655   2019

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    <p>Background and Aim: Extensive use of laxatives and incomplete excretion rates are problematic for colon capsule endoscopy (CCE). The aim of the present study was to determine the effectiveness of castor oil as a booster.</p><p>Methods: At four Japanese hospitals, 319 examinees undergoing CCE were enrolled retrospectively. Before and after the introduction of castor oil, other preparation reagents were unchanged.</p><p>Results: Of 319 examinees who underwent CCE, 152 and 167 examinees took regimens with castor oil (between November 2013 and June 2016) and without castor oil (between October 2015 and September 2017), respectively. Capsule excretion rates within its battery life in the groups with and without castor oil were 97% and 81%, respectively (<i>P</i><0.0001). Multivariate analysis showed that ages younger than 65 years (adjusted odds ratio [OR], 3.00; <i>P</i>=0.0048), male gender (adjusted OR, 3.20; <i>P</i>=0.0051), and use of castor oil (adjusted OR, 6.29; <i>P</i>=0.0003) were predictors of capsule excretion within its battery life. Small bowel transit time was shorter and total volume of lavage and fluid intake was lower with castor oil than without (<i>P</i> = 0.0154 and 0.0013, respectively). Overall adequate cleansing level ratios with and without castor oil were 74% and 83%, respectively (<i>P</i> = 0.0713). Per-examinee sensitivity for polyps ≥6 mm with and without castor oil was 83% and 85%, respectively, with specificities of 80% and 78%, respectively.</p><p>Conclusion: Bowel preparation with castor oil was effective for improving capsule excretion rate and reducing liquid loading.</p>

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  164. Perceptions and behavior related to noncommunicable diseases among slum dwellers in a rapidly urbanizing city, Dhaka, Bangladesh: a qualitative study Reviewed International coauthorship

    Al-Shoaibi Abubakr Ahmed Abdullah, Matsuyama Akiko, Khalequzzaman Md, Haseen Fariha, Choudhury Sohel Reza, Hoque Bilqis Amin, Chiang Chifa, Hirakawa Yoshihisa, Yatsuya Hiroshi, Aoyama Atsuko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 4 ) page: 559 - 569   2018.11

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    The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an urban slum community in Dhaka. Qualitative methods were employed to explore a general understanding of behavior related to NCDs among residents of the slum community. We conducted key informant interviews of six men and seven women of various backgrounds and five focus group discussions to focus salient topics emerged from the interviews. The transcriptions of the audio-recordings were thematically analyzed, using the constant comparison method. Four major themes emerged: (1) financial hardship influencing health; (2) urbanized lifestyle affecting diet; (3) tobacco and sweetened tea as cornerstones of social life; and (4) health-seeking behavior utilizing local resources. One notable finding was that even with general economic improvement, respondents perceived poverty to be one of the major causes of NCDs. A promising finding for potentially curbing NCDs was the current trend for women to walk for exercise contrary to the commonly held notion that urban dwellers generally lead sedentary lifestyles. This study described how urban slum dwellers in Dhaka, experiencing a transition from a traditional to urbanized lifestyle, perceived their daily practices in relation to NCDs and nutrition. Our research revealed both adverse and encouraging elements of perceptions and behavior related to NCDs, which may contribute to the optimal design of NCD prevention and health promotion programs.

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  165. Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation. Reviewed International journal

    Yasui T, Suzuki T, Yoshikawa T, Yatsuya H, Kawamura Y, Miura H, Hara F, Watanabe S, Uga N, Naoe A

    Pediatric transplantation   Vol. 22 ( 7 ) page: e13239   2018.11

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    Differentiation between active and latent viral infection is critical for analysis of HHV-6-associated disease. HHV-6 infection has been associated with several clinical manifestations; however, the precise role of HHV-6 in pediatric LDLT remains unclear. This retrospective cohort study included 33 pediatric patients who received LDLT. All of the recipients were monitored for HHV-6 infection using viral isolation and real-time PCR. HHV-6 infection was observed in 14 of 33 (42.4%) recipients, and HHV-6B infection occurred within 2 weeks after LDLT in 10 of 14 (71.4%) recipients. HHV-6 was isolated from 10 of 33 (30.3%) recipients. Multivariate analysis showed that independent predictors of HHV-6B infection were age (OR 0.975; 95% CI 0.943-0.999; P = .041), PELD (OR 1.091; P = .038), and biliary atresia (OR 16.48; P = .035). The occurrence of unexplained fever was significantly higher in recipients with HHV-6B infection (11/14) compared with uninfected recipients (6/19) (P = .013). Additionally, ALT levels at 8 and 9 weeks after transplantation were significantly higher in the recipients with HHV-6B infection. Younger age, high MELD/PELD score, and biliary atresia as an underlying disease were identified as risk factors for viral infection.

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  166. Perception and practice of 'healthy' diet in relation to noncommunicable diseases among the urban and rural people in northern Ethiopia: a community-based qualitative study Reviewed International coauthorship

    Gebremariam Lemlem Weldegerima, Aoyama Atsuko, Kahsay Alemayehu Bayray, Hirakawa Yoshihisa, Chiang Chifa, Yatsuya Hiroshi, Matsuyama Akiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 4 ) page: 451 - 464   2018.11

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    Dietary habits are related to the risks of noncommunicable diseases (NCDs), such as cardiovascular disease and diabetes, of which burdens are increasing in low-income countries including Ethiopia. Although several epidemiological studies of NCD risk factors were conducted in Ethiopia, qualitative studies on people's dietary habit in relation to NCDs have not been conducted yet. This study aims to describe people's perception and practice of 'healthy' diet, and barriers to practice 'healthy' diet, paying attention to the dynamics between the perception and practice. We conducted 16 key informant interviews and eight focus group discussions in an urban and a rural areas in northern Ethiopia between November 2014 and January 2016. Audio-records in local language were transcribed word-for-word, and translated into English. English text data were analyzed qualitatively, through constant comparative analysis following the principles of the grounded theory. Three themes have emerged: (1) dietary habit perceived as 'good' or 'bad' for health; (2) reasons for continuing current 'unhealthy' dietary habit; and (3) current dietary habit perceived as 'traditional.' People's practice was mostly consistent with their perception, while they sometimes practiced contrary to the perception because of personal preference and physical or financial obstacles. People were often indifferent of health implications of their habitual dietary practice, such as drinking a lot of sweet coffee. We showed dynamics between perception and practice of 'healthy' diet among people in northern Ethiopia. It is needed to increase awareness of NCDs both among the urban and rural people and to improve the social environment for removing the obstacles.

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  167. HYPERTENSION DETECTION, TREATMENT AND CONTROL RATES IN URBAN SLUM POPULATION IN BANGLADESH Reviewed International coauthorship

    Choudhury Sohel, Al-Shoaibi Abubakr Ahmed Abdullah, Khalequzzaman Mohammad, Al Mamun Mohammad Abdullah, Chiang Chifa, Yatsuya Hiroshi, Aoyama Atsuko

    JOURNAL OF HYPERTENSION   Vol. 36   page: E337 - E338   2018.10

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  168. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study. Reviewed International journal

    Kokubo Y, Saito I, Iso H, Yamagishi K, Yatsuya H, Ishihara J, Maruyama K, Inoue M, Sawada N, Tsugane S, JPHC Study Group

    Clinical nutrition (Edinburgh, Scotland)   Vol. 37 ( 5 ) page: 1602 - 1608   2018.10

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    BACKGROUND & AIMS: The associations between dietary magnesium intake and stroke and coronary heart disease (CHD) incidences are inconsistent and not established in Asian. We aimed to determine the association between dietary magnesium intake and the risk of stroke and CHD in a Japanese population. SUBJECTS/METHODS: We studied 85,293 Japanese subjects by questionnaire at baseline (age 45-74 years, without cardiovascular disease or cancer in 1995 and 1998 for Cohorts I and II, respectively). The participants were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138-item food-frequency questionnaire. RESULTS: After 1,305,738 person-years of follow-up, 4110 strokes and 1283 cases of CHD were documented. The multivariable-adjusted hazard ratios (HRs, 95% confidence intervals, 95%CIs) of CHD for the fourth and fifth quintiles of dietary magnesium intake were 0.70 (0.50-0.99) and 0.66 (0.44-0.97) in men (P for trend = 0.036), respectively, and third quintile of dietary magnesium intake was 0.61 (0.39-0.96) in women (P for trend = 0.241), compared with the lowest quintile in men and women. We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. CONCLUSIONS: Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men.

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  169. γGTPとALT追加による10年間の2型糖尿病発症リスク予測能の改善 愛知職域コホート Reviewed

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 豊嶋 英明, 青山 温子

    日本公衆衛生学会総会抄録集   Vol. 77回   page: 204 - 204   2018.10

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  170. 食品摂取の多様性と尿中Na,K排泄量、血圧との関連 NIPPON DATA2010

    大塚 礼, 八谷 寛, 西 信雄, 奥田 奈賀子, 門田 文, 由田 克士, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之

    日本公衆衛生学会総会抄録集   Vol. 77回   page: 322 - 322   2018.10

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  171. The association between objective measures of residence and worksite neighborhood environment, and self-reported leisure-time physical activities: The Aichi Workers' Cohort Study. Reviewed International journal

    Yuanying Li, Hiroshi Yatsuya, Tomoya Hanibuchi, Yoshihisa Hirakawa, Atsuhiko Ota, Mayu Uemura, Chifa Chiang, Rei Otsuka, Chiyoe Murata, Koji Tamakoshi, Hideaki Toyoshima, Atsuko Aoyama

    Preventive medicine reports   Vol. 11   page: 282 - 289   2018.9

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    The possible effects of a neighborhood's built environment on physical activity have not been studied in Asian countries as much as in Western countries. The present study cross-sectionally examined the relationship between geographic information system (GIS) measured residence and worksite neighborhood walkability, and the number of parks/green spaces and sports facilities within a 1 km radius of home and workplace, with self-reported leisure-time habitual (3-4 times per week or more) walking and moderate-to-vigorous intensity habitual exercise among local government workers aged 18 to 64 years living in an urban-suburban area of Aichi, Japan in 2013. A single-level binomial regression model was used to estimate the multivariable odds ratios (ORs) and 95% confidence intervals (95% CIs). Of the 1959 male and 884 female participants, 288 (15%) and 141 (16%) reported habitual walking, respectively, and 18% and 17% reported habitual exercise, respectively. Compared with women who resided in neighborhood with a walkability index of 4-30, those living in an area with that of 35-40 were significantly more likely to engage in leisure-time habitual exercise (multivariable OR: 1.70, 95% CI: 1.08-2.68). Marginally significant positive associations were found between leisure-time habitual exercise and the residential neighborhood's number of parks/green spaces among women, as well as the number of sports facilities among men. In conclusion, a residential neighborhood environment characterized by higher walkability may contribute to the initiation or maintenance of moderate-to-vigorous intensity leisure-time exercise among working women living in an urban-suburban area of Japan.

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  172. Pooled analysis of the associations between body mass index, total cholesterol, and liver cancer-related mortality in Japan Reviewed

    Ukawa S, Tamakoshi A, Murakami Y, Kiyohara Y, Yamada M, Nagai M, Satoh A, Miura K, Ueshima H, Okamura T, Imai Y, Ohkubo T, Irie F, Iso H, Kitamura A, Ninomiya T, Nakagawa H, Nakayama T, Okayama A, Sairenchi T, Saitoh S, Sakata K, Tsuji I, Kiyama M, Miyamoto Y, Ishikawa S, Yatsuya H

    Asian Pacific Journal of Cancer Prevention   Vol. 19 ( 8 ) page: 2089 - 2095   2018.8

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    © 2018 Asian Pacific Organization for Cancer Prevention. Objective: We employed a large-scale pooled analysis to investigate the association of liver cancer-related mortality with being overweight/obese and total cholesterol (TC) levels, since limited and inconsistent data on these associations exist in Japan. Methods: A total of 59,332 participants (23,853 men and 35,479 women) from 12 cohorts without a history of cancer who were followed for a median of 14.3 years were analyzed. A sex-specific stratified Cox proportional hazards model adjusted for age and other potential confounders was used to calculate hazard ratios (HRs) and 95% confidence intervals (CI) for liver cancer-related mortality. Results: A total of 447 participants (266 men and 181 women) died of liver cancer within the follow-up period. Individuals classified as having a high BMI (≥25.0 kg/m2) and low TC levels (&lt; 160 mg/dL) had a significantly increased risk for liver cancer-related mortality (HR 7.05, 95% CI 4.41-11.26 in men; HR 8.07, 95% CI 4.76-13.67 in women) when compared with those in the intermediate BMI (18.5-24.9 kg/m2) and TC (160-219 mg/dL) categories. These associations remained after limiting the

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  173. Late-phase human herpesvirus 6B reactivation in hematopoietic stem cell transplant recipients. Reviewed International journal

    Hiroki Miura, Yoshiki Kawamura, Fumihiko Hattori, Makito Tanaka, Kazuko Kudo, Masaru Ihira, Hiroshi Yatsuya, Yoshiyuki Takahashi, Seiji Kojima, Tetsushi Yoshikawa

    Transplant infectious disease : an official journal of the Transplantation Society   Vol. 20 ( 4 ) page: e12916   2018.8

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    BACKGROUND: We sought to determine whether late-phase human herpesvirus 6B (HHV-6B) infection in hematopoietic stem cell transplant (HSCT) recipients was associated with serious outcomes and mortality. METHODS: The occurrence and course of HHV-6B infection was monitored for at least 60 days after transplant using virus isolation and real-time polymerase chain reaction. Risk factors for late-phase HHV-6B infection were examined, and the propensity score was calculated with significant risk factors. The inverse probability-weighted multivariable logistic regression analysis was performed to estimate odds ratios (ORs) and the 95% confidence intervals (95% CI) for mortality. RESULTS: Late-phase HHV-6B infection was observed in 12/89 (13.5%) of the HSCT recipients. Older age (OR: 10.3, 95% CI: 2.1/72.9, P = .0027), hematologic malignancy (OR: 10.3, 95% CI: 1.8/97.1, P = .0063), unrelated donor transplantation (OR: 5.3, 95% CI: 1.1/36.0, P = .0345), and sex-mismatched donor transplantation (OR: 6.3, 95% CI: 1.4/39.5, P = .0149) were identified as risk factors for late-phase HHV-6B infection. Fifteen subjects died (17%). Inverse probability-weighted multivariable logistic model analysis revealed that late-phase HHV-6B infection was an independent risk factor for mortality (OR: 4.2, 95% CI: 1.7/11.0, P = .0012). Among 5 of the fatal cases of late-phase HHV-6B infection, viral infection might be associated with severe clinical manifestations. CONCLUSION: Late-phase HHV-6B infection in HSCT recipients was associated with worse outcomes. The full spectrum of clinical features of the infection has not been fully elucidated, and therefore, recipients with high-risk factors for late-phase HHV-6B infection should be carefully monitored.

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  174. Cardiovascular disease mortality in relation to physical activity during adolescence and adulthood in Japan: Does school-based sport club participation matter? Reviewed International coauthorship International journal

    Krisztina Gero, Hiroyasu Iso, Akihiko Kitamura, Kazumasa Yamagishi, Hiroshi Yatsuya, Akiko Tamakoshi

    Preventive Medicine   Vol. 113   page: 102 - 108   2018.8

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    We examined potential associations of sport club participation during adolescence and sports-related physical activity during adulthood with mortality from cardiovascular diseases (CVD) in a Japanese population. Between 1988 and 1990, 29,526 men and 41,043 women aged 40–79 years responded to a questionnaire including questions about the frequency of sports participation at baseline and sport club participation during junior/senior high school. Subjects were followed-up until the end of 2009, and 4230 cardiovascular deaths (870 CHD, 1859 stroke) were identified. Cox proportional-hazard regression models were used to estimate hazard ratios (HR). During the first-two thirds of the follow-up – where the proportional hazards assumption was met – the multivariate-adjusted HR (95% confidence interval) for total CVD mortality was 0.77 (0.61–0.98) among men and 0.82 (0.61–1.10) among women who were physically active at baseline (≥5 h/week versus 1–2 h/week). The corresponding HRs for coronary heart disease (CHD) mortality were 0.65 (0.39–1.07) and 0.40 (0.17–0.91), respectively. The combined associations of sports participation during adulthood and adolescence were also examined. Among men who participated in sports for ≥5 h/week at baseline, the multivariate-adjusted HR for those who also engaged in sport club activities during adolescence was 0.89 (0.61–1.30) for total CVD mortality and 0.24 (0.08–0.71) for CHD mortality when compared to non-participants. Among women, no statistically significant differences were found between sport club participants and non-participants. In conclusion, participating in sport clubs during adolescence might lead to a more pronounced risk-reduction for CHD mortality among men who also participate in sport activities during adulthood.

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  175. Effect of laughter yoga on salivary cortisol and dehydroepiandrosterone among healthy university students: A randomized controlled trial Reviewed International journal

    Akiko Fujisawa, Atsuhiko Ota, Masaaki Matsunaga, Yuanying Li, Masako Kakizaki, Hisao Naito, Hiroshi Yatsuya

    Complementary Therapies in Clinical Practice   Vol. 32   page: 6 - 11   2018.8

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    Objective: To examine whether laughter yoga (LY), i.e., simulated laughter, alters cortisol and dehydroepiandrosterone (DHEA) levels and cortisol/DHEA (C/D) ratios. Methods: In a randomized controlled trial, 120 healthy university students were allocated to experiencing LY, watching a comedy movie (spontaneous laughter), or reading a book. Salivary cortisol and DHEA levels were measured immediately before, immediately after, and 30 min after the intervention. Results: Cortisol levels and C/D ratios significantly decreased by time in the LY and comedy movie groups. Significant group*time interactions were found between these two groups for cortisol levels and C/D ratios. DHEA levels did not change by time in the LY group. Conclusions: LY decreased cortisol levels and C/D ratios but did not affect DHEA levels. Simulated and spontaneous laughter differently affected the dynamics of cortisol levels and C/D ratios. Effect of spontaneous laughter on the cortisol dynamics lasted longer than that of simulated laughter. (UMIN000019409).

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  176. Non-communicable disease risk factor profile among public employees in a regional city in northern Ethiopia Reviewed International coauthorship International journal

    Lemlem Weldegerima Gebremariam, Chifa Chiang, Hiroshi Yatsuya, Esayas Haregot Hilawe, Alemayehu Bayray Kahsay, Hagos Godefay, Loko Abraham, Yoshihisa Hirakawa, Hiroyasu Iso, Atsuko Aoyama

    Scientific Reports   Vol. 8 ( 1 ) page: 9298   2018.6

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    The burden of non-communicable diseases (NCDs) is increasing in Ethiopia. This study aims to describe the prevalence of NCD risk factors of public employees in a regional city in northern Ethiopia. We conducted a cross-sectional epidemiological study targeting men and women aged 25-64 years employed by public offices in Mekelle. The prevalence was age-standardized to the Ethiopian 2007 population. Among the 1380 subjects (823 men and 557 women), 68.7% had less than 1 serving of fruits and vegetables per day, 41.0% were physically inactive, and 57.3% observed religious fast. The age-standardised prevalence of abdominal obesity was 29.3% in men and 58.5% in women, but that of metabolic syndrome was comparable between men (39.2%) and women (39.0%). The prevalence of diabetes was underestimated if only fasting blood glucose (FBG) was used for the diagnosis compared to combination of FBG and glycated haemoglobin (HbA1c) (6.7% in men and 3.8% in women vs. 12.1% in men and 5.6% in women). More than a quarter (26.1%) of men and 8.7% of women had estimated 10-year risk of cardiovascular disease of 10% or more. This study revealed the high prevalence of NCD metabolic risk factors among the urban public employees in the highland of Ethiopia.

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  177. Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH–JAPAN study Reviewed

    Aya Hirata, Daisuke Sugiyama, Makoto Watanabe, Akiko Tamakoshi, Hiroyasu Iso, Kazuhiko Kotani, Masahiko Kiyama, Michiko Yamada, Shizukiyo Ishikawa, Yoshitaka Murakami, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Toshiharu Ninomiya, Yutaka Kiyohara, Katsuyuki Miura, Yoshitaka Murakami, Hideaki Nakagawa, Takeo Nakayama, Akira Okayama, Toshimi Sairenchi, Shigeyuki Saitoh, Kiyomi Sakata, Akiko Tamakoshi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya, Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH–JAPAN) Research Group

    Journal of Clinical Lipidology   Vol. 12 ( 3 ) page: 674 - 684.e5   2018.5

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    Background: The effect of very high or extremely high levels of high-density lipoprotein cholesterol (HDL-C) on cardiovascular disease (CVD) is not well described. Although a few recent studies have reported the adverse effects of extremely high levels of HDL-C on CVD events, these did not show a statistically significant association between extremely high levels of HDL-C and cause-specific CVD mortality. In addition, Asian populations have not been studied. Objective: We examine the impact of extremely high levels of HDL-C on cause-specific CVD mortality using pooled data of Japanese cohort studies. Methods: We performed a large-scale pooled analysis of 9 Japanese cohorts including 43,407 participants aged 40–89 years, dividing the participants into 5 groups by HDL-C levels, including extremely high levels of HDL-C ≥2.33 mmol/L (≥90 mg/dL). We estimated the adjusted hazard ratio of each HDL-C category for all-cause death and cause-specific deaths compared with HDL-C 1.04–1.55 mmol/L (40–59 mg/dL) using a cohort-stratified Cox proportional hazards model. Results: During a 12.1-year follow-up, 4995 all-cause deaths and 1280 deaths due to overall CVD were identified. Extremely high levels of HDL-C were significantly associated with increased risk of atherosclerotic CVD mortality (hazard ratio = 2.37, 95% confidence interval: 1.37–4.09 for total) and increased risk for coronary heart disease and ischemic stroke. In addition, the risk for extremely high HDL-C was more evident among current drinkers. Conclusion: We showed extremely high levels of HDL-C had an adverse effect on atherosclerotic CVD mortality in a pooled analysis of Japanese cohorts.

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  178. 降圧剤の投与は高血圧ラット肝臓Cyp7a1プロモーターのメチル化頻度を低下させる

    内藤 久雄, 三宅 邦夫, 袁 援, 橋本 沙幸, 浅野 友美, 北森 一哉, 八谷 寛, 那須 民江

    産業衛生学雑誌   Vol. 60 ( 臨増 ) page: 303 - 303   2018.5

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  179. Association between average daily television viewing time and the incidence of ovarian cancer: findings from the Japan Collaborative Cohort Study. Reviewed International journal

    Shigekazu Ukawa, Akiko Tamakoshi, Mitsuru Mori, Satoyo Ikehara, Toru Shirakawa, Hiroshi Yatsuya, Hiroyasu Iso

    Cancer causes & control : CCC   Vol. 29 ( 2 ) page: 213 - 219   2018.2

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    PURPOSE: Seventy-five percent of epidemiological studies have reported that sedentary behavior is associated with ovarian cancer incidence. Although Japan has one of the most sedentary populations, with median sitting times of 7 h/day, this association has not been investigated. This study aimed to elucidate the association between average daily television (TV) viewing time, which is a major sedentary behavior, and the incidence of ovarian cancer in a large-scale nationwide cohort study in Japan. METHODS: A total of 34,758 female participants aged 40-79 years without a history of cancer at baseline were included in the study. The inverse probability weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the incidence of ovarian cancer. RESULTS: During a median follow-up of 19.4 years, 59 participants developed ovarian cancer (ICD-10: C56), 2,706 participants developed other types of cancer, and 4,318 participants died. Participants who watched TV for ≥ 5 h/day were more likely to develop ovarian cancer than those who watched TV for < 2 h/day (HR 2.15; 95% CI 1.54-2.99). CONCLUSION: Our findings suggest that reducing the amount of time spent sedentarily may be beneficial for preventing ovarian cancer.

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  180. Relationships among Socioeconomic Factors and Self-rated Health in Japanese Adults: NIPPON DATA2010. Reviewed

    Ota A, Yatsuya H, Nishi N, Okuda N, Ohkubo T, Hayakawa T, Kadota A, Okayama A, Miura K

    Journal of epidemiology   Vol. 28 ( Supplement_III ) page: S66 - S72   2018

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    BACKGROUND: The distributions of socioeconomic status (SES) factors have been changing in Japan. We examined the relationships among SES and self-rated health (SRH) in Japanese adults. METHODS: We analyzed 1,178 men and 1,555 women. We showed the distribution of SRH by sex and age and examined cross-sectional relationships among educational attainment, marital/living statuses, working status, household income and expenditure, and fine SRH (defined as excellent, very good, or good). We adjusted for age, subjective symptoms, visiting doctors, monthly equivalent household expenditure (EHE), and living in their own house. RESULTS: The age-standardized prevalence of fine SRH was 79% and 73% among men and women, respectively. Among men, graduating from high school (adjusted odds ratio [aOR] 1.53; 95% confidence interval [CI], 1.07-2.19, relative to graduating from elementary or junior high school) and university or junior college (aOR 1.74; 95% CI, 1.15-2.62) was associated with fine SRH. Among women, graduating from university or junior college was associated with fine SRH (aOR 1.65; 95% CI, 1.12-2.46). Neither marital/living status nor working status was associated with SRH after adjustments for age in either sex. Among women, high EHE and income were associated with fine SRH (the highest expenditure group: aOR 1.80; 95% CI, 1.22-2.65; the highest income group: aOR 2.15; 95% CI, 1.34-3.46, relative to the corresponding lowest group). These simple relationships were not observed for men. CONCLUSIONS: High educational attainment was associated with fine SRH. Relationships among household income, EHE, and fine SRH differed by sex.

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  181. [Study on the probability of incident stroke and acute myocardial infarction using DPC data]. Reviewed

    Masako Kakizaki, Norie Sawada, Kazumasa Yamagishi, Hiroshi Yatsuya, Isao Saito, Yoshihiro Kokubo, Hiroyasu Iso, Shoichiro Tsugane, Hideo Yasunaga

    [Nihon koshu eisei zasshi] Japanese journal of public health   Vol. 65 ( 4 ) page: 179 - 186   2018

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  182. A Point System for Predicting 10-Year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study. Reviewed

    Yatsuya H, Li Y, Hirakawa Y, Ota A, Matsunaga M, Haregot HE, Chiang C, Zhang Y, Tamakoshi K, Toyoshima H, Aoyama A

    Journal of epidemiology   Vol. 28 ( 8 ) page: 347 - 352   2018

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    BACKGROUND: Relatively little evidence exists for type 2 diabetes mellitus (T2DM) prediction models from long-term follow-up studies in East Asians. This study aims to develop a point-based prediction model for 10-year risk of developing T2DM in middle-aged Japanese men. METHODS: We followed 3,540 male participants of Aichi Workers' Cohort Study, who were aged 35-64 years and were free of diabetes in 2002, until March 31, 2015. Baseline age, body mass index (BMI), smoking status, alcohol consumption, regular exercise, medication for dyslipidemia, diabetes family history, and blood levels of triglycerides (TG), high density lipoprotein cholesterol (HDLC) and fasting blood glucose (FBG) were examined using Cox proportional hazard model. Variables significantly associated with T2DM in univariable models were simultaneously entered in a multivariable model for determination of the final model using backward variable selection. Performance of an existing T2DM model when applied to the current dataset was compared to that obtained in the present study's model. RESULTS: During the median follow-up of 12.2 years, 342 incident T2DM cases were documented. The prediction system using points assigned to age, BMI, smoking status, diabetes family history, and TG and FBG showed reasonable discrimination (c-index: 0.77) and goodness-of-fit (Hosmer-Lemeshow test, P = 0.22). The present model outperformed the previous one in the present subjects. CONCLUSION: The point system, once validated in the other populations, could be applied to middle-aged Japanese male workers to identify those at high risk of developing T2DM. In addition, further investigation is also required to examine whether the use of this system will reduce incidence.

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  183. 肥満と動脈硬化

    八谷 寛, 李 媛英, 金子 佳世, 太田 充彦

    食と医療   Vol. 4   page: 72 - 79   2018

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  184. Prevalence of non-communicable disease risk factors among poor shantytown residents in Dhaka, Bangladesh: a community-based cross-sectional survey. Reviewed International coauthorship International journal

    Khalequzzaman M, Chiang C, Choudhury SR, Yatsuya H, Al-Mamun MA, Al-Shoaibi AAA, Hirakawa Y, Hoque BA, Islam SS, Matsuyama A, Iso H, Aoyama A

    BMJ open   Vol. 7 ( 11 ) page: e014710   2017.11

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    OBJECTIVES: This study aims to describe the prevalence of non-communicable disease (NCD) risk factors among the urban poor in Bangladesh. DESIGN: We conducted a community-based cross-sectional epidemiological study. SETTING: The study was conducted in a shantytown in the city of Dhaka. There were 8604 households with 34 170 residents in the community. Those households were categorised into two wealth strata based on the housing structure. PARTICIPANTS: The study targeted residents aged 18-64 years. A total of 2986 eligible households with one eligible individual were selected by simple random sampling stratified by household wealth status. A total of 2551 residents completed the questionnaire survey, and 2009 participated in the subsequent physical and biochemical measurements. OUTCOME MEASURES: A modified WHO survey instrument was used for assessing behavioural risk factors and physical and biochemical measurements, including glycated haemoglobin (HbA1c). The prevalence of NCD risk factors, such as tobacco use, fruit and vegetable intake, overweight/obesity, hypertension, diabetes (HbA1c ≥6.5%) and dyslipidaemia, was described according to household wealth status and gender differences. RESULTS: The prevalence of current tobacco use was 60.4% in men and 23.5% in women. Most of them (90.8%) consumed more than 1 serving of fruits and vegetables per day; however, only 2.1% consumed more than 5 servings. Overweight/obesity was more common in women (39.2%) than in men (18.9%), while underweight was more common in men (21.0%) than in women (7.1%). The prevalence of hypertension was 18.6% in men and 20.7% in women. The prevalence of diabetes was 15.6% in men and 22.5% in women, which was much higher than the estimated national prevalence (7%). The prevalence of raised total cholesterol (≥190 mg/dL) was 25.7% in men and 34.0% in women. CONCLUSION: The study identified that tobacco use, both overweight and underweight, diabetes, hypertension and dyslipidaemia were prevalent among the urban poor in Bangladesh.

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  185. Alcohol consumption and mortality from aortic disease among Japanese men: The Japan Collaborative Cohort study Reviewed International journal

    Toru Shirakawa, Kazumasa Yamagishi, Hiroshi Yatsuya, Naohito Tanabe, Akiko Tamakoshi, Hiroyasu Iso

    ATHEROSCLEROSIS   Vol. 266   page: 64 - 68   2017.11

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    Background and aims: Only a few population-based prospective studies have examined the association between alcohol consumption and abdominal aortic aneurysm, and the results are inconsistent. Moreover, no evidence exists for aortic dissection. We examined the effect of alcohol consumption on risk of mortality from aortic diseases.
    Methods: A total of 34,720 men from the Japan Collaborative Cohort study, aged 40-79 years, without history of cardiovascular disease and cancer at baseline 1988 and 1990 were followed up until the end of 2009 for their mortality and its underlying cause. Hazard ratios of mortality from aortic diseases were estimated according to alcohol consumption categories of never-drinkers, ex-drinkers, regular drinkers of &lt;= 30 g, and &gt; 30 g ethanol per day.
    Results: During the median 17.9-year follow-up period, 45 men died of aortic dissection and 41 men died of abdominal aortic aneurysm. Light to moderate drinkers of &lt;= 30 g ethanol per day had lower risk of mortality from total aortic disease and aortic dissection compared to never-drinkers. The respective multivariable hazard ratios (95% confidence intervals) were 0.46 (0.28-0.76) for total aortic disease and 0.16 (0.05-0.50) for aortic dissection. Heavy drinkers of &gt; 30 g ethanol per day did not have reduced risk of mortality from total aortic disease, albeit had risk variation between aortic dissection and abdominal aortic aneurysm.
    Conclusions: Light to moderate alcohol consumption was associated with reduced mortality from aortic disease among Japanese men. (C) 2017 Published by Elsevier Ireland Ltd.

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  186. Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study Reviewed International journal

    Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane

    ATHEROSCLEROSIS   Vol. 265   page: 147 - 154   2017.10

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    Background and aims: Although low high-density lipoprotein (HDL) cholesterol concentration is an established risk factor for coronary heart disease (CHD), information regarding subtypes of stroke is very limited, especially in Asian populations.
    Methods: A prospective study was conducted among 30,736 individuals aged 40-69 years, who lived in nine communities in Japan and did not have a history of cardiovascular disease (CVD). CHD and stroke, including its subtypes, were assessed, and sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were estimated according to quintiles of HDL cholesterol using Cox proportional models adjusted for other CVD risk factors.
    Results: We identified 296 CHD and 1712 stroke events over a median 15 yr of follow-up. HDL cholesterol concentration showed an inverse association with CHD in men and women. A low HDL cholesterol concentration slightly raised the risk for total strokes in men, but not in women. When analyzed by subtypes, we observed an inverse relationship between HDL cholesterol concentration and the incidence of lacunar infarction, with an adjusted HR for the lowest quintile of HDL cholesterol concentration compared with the highest quintile of 1.63 (95% CI, 1.00-2.66) in men and 1.97 (95% CI, 1.19-3.26) in women. HDL cholesterol concentration was positively associated with the risk of intracerebral hemorrhage (ICH) in a linear manner in women (p for trend = 0.028), but not in men.
    Conclusions: The associations of HDL cholesterol concentration with lacunar infarction and ICH may be related to different functional properties of HDL rather than to its protective function against lipid-rich atherosclerosis. (C) 2017 Elsevier B.V. All rights reserved.

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  187. Functional capacity, self-rated health status, and psychosocial characteristics of employed cancer survivors in Japan Reviewed International journal

    Katoh Y, Ota A, Yatsuya H, Li Y, Naito H, Fujisawa A, Matsunaga M, Hirakawa Y, Chiang C, Toyoshima H, Tamakoshi K, Aoyama A

    Fujita Medical Journal   Vol. 3 ( 3 ) page: 55 - 61   2017.8

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    <p><b>Objectives:</b> This study investigated restrictions in functional capacity, self-rated health status (SRHS), and psychosocial characteristics of employed cancer survivors in Japan and examined differences in these characteristics between cancer survivors and employees without cancer history.</p><p><b>Methods:</b> A cross-sectional survey was carried out. Subjects were local government employees in Japan in 2013 (n=5,474). Using a self-administered questionnaire, we evaluated restrictions in functional capacity, SRHS, and the following psychosocial characteristics: social support, perceived stress, social capital, positive reasons for living (ikigai), and happiness. We examined whether cancer history was associated with restrictions in functional capacity, SRHS, and psychosocial characteristics.</p><p><b>Results:</b> A total of 112 employees were cancer survivors. Of these, males of all ages and comparatively younger females had restrictions in functional capacity more frequently than the corresponding subjects without cancer history (males of all ages: 14.5% vs. 2.9%, p<0.001; females <50 years: 15.2% vs. 1.1%, p<0.001). Among males of all ages, cancer survivors reported bad SRHS more frequently than employees without cancer history (8.1% vs. 1.5%, p=0.003). No significant differences were found in psychosocial characteristics by cancer history.</p><p><b>Conclusions:</b> Male and comparatively young female employed cancer survivors frequently experienced restrictions in functional capacity. Male employed cancer survivors self-rated their health status as bad more frequently than male employees without cancer history.</p>

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  188. A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan Reviewed

    Takumi Hirata, Daisuke Sugiyama, Shin-ya Nagasawa, Yoshitaka Murakami, Shigeyuki Saitoh, Akira Okayama, Hiroyasu Iso, Fujiko Irie, Toshimi Sairenchi, Yoshihiro Miyamoto, Michiko Yamada, Shizukiyo Ishikawa, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, for the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Yutaka Kiyohara, Katsuyuki Miura, Yoshitaka Murakami, Hideaki Nakagawa, Takeo Nakayama, Akira Okayama, Toshimi Sairenchi, Shigeyuki Saitoh, Kiyomi Sakata, Akiko Tamakoshi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya, Tomonori Okamura

    European Journal of Epidemiology   Vol. 32 ( 7 ) page: 547 - 557   2017.7

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    Low levels of serum high-density lipoprotein cholesterol (HDL-C) have been shown to be associated with increased risk of coronary heart disease (CHD). However, because this is usually observed in the context of other lipid abnormalities, it is not known whether isolated low serum HDL-C levels are an independent risk factor for CHD. We performed a large pooled analysis in Japan using data from nine cohorts with 41,206 participants aged 40–89 years who were free of cardiovascular disease at baseline. We divided participants into three groups: isolated low HDL-C, non-isolated low HDL-C, and normal HDL-C. Cohort-stratified Cox proportional hazards models were used to estimate multivariate-adjusted hazard ratios (HRs) for death due to CHD, ischemic stroke, and intracranial cerebral hemorrhage
    during a 12.9-year follow-up, we observed 355, 286, and 138 deaths, respectively, in these groups. Non-isolated low HDL-C was significantly associated with increased risk of CHD compared with normal HDL-C (HR 1.37, 95 % confidence interval (CI) 1.04–1.80)
    however, isolated low HDL-C was not. Although isolated low HDL-C was significantly associated with decreased risk of CHD (HR 0.51, 95 % CI 0.29–0.89) in women, it was significantly associated with increased risk of intracranial cerebral hemorrhage in all participants (HR 1.62, 95 % CI 1.04–2.53) and in men (HR 2.00, 95 % CI 1.04–3.83). In conclusion, isolated low HDL-C levels are not associated with increased risk of CHD in Japan. CHD risk may, therefore, be more strongly affected by serum total cholesterol levels in this population.

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  189. Synergistic and Non-synergistic Associations for Cigarette Smoking and Non-tobacco Risk Factors for Cardiovascular Disease Incidence in the Atherosclerosis Risk In Communities (ARIC) Study Reviewed International coauthorship International journal

    Jay H. Lubin, David Couper, Pamela L. Lutsey, Hiroshi Yatsuya

    NICOTINE & TOBACCO RESEARCH   Vol. 19 ( 7 ) page: 826 - 835   2017.7

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    Cigarette smoking, various metabolic and lipid-related factors and hypertension are well-recognized cardiovascular disease (CVD) risk factors. Since smoking affects many of these factors, use of a single imprecise smoking metric, for example, ever or never smoked, may allow residual confounding and explain inconsistencies in current assessments of interactions.
    Using a comprehensive model in pack-years and cigarettes/day for the complex smoking-related relative risk (RR) of CVD to reduce residual confounding, we evaluated interactions with non-tobacco risk factors, including additive (non-synergistic) and multiplicative (synergistic) forms. Data were from the prospective Atherosclerosis Risk in Communities (ARIC) Study from four areas of the United States recruited in 1987-1989 with follow-up through 2008. Analyses included 14 127 participants, 207 693 person-years and 2857 CVD events.
    Analyses revealed distinct interactions with smoking: including statistical consistency with additive (body mass index [BMI], waist to hip ratio [WHR], diabetes mellitus [DM], glucose, insulin, high density lipoproteins [HDL] and HDL(2)); and multiplicative (hypertension, total cholesterol [TC], low density lipoproteins [LDLs], apolipoprotein B [apoB], TC to HDL ratio and HDL(3)) associations, as well as indeterminate (apolipoprotein A-I [apoA-I] and triglycerides) associations.
    The forms of the interactions were revealing but require confirmation. Improved understanding of joint associations may help clarify the public health burden of smoking for CVD, links between etiologic factors and biological mechanisms, and the consequences of joint exposures, whereby synergistic associations highlight joint effects and non-synergistic associations suggest distinct contributions.
    Joint associations for cigarette smoking and non-tobacco risk factors were distinct, revealing synergistic/multiplicative (hypertension, TC, LDL, apoB, TC/HDL, HDL(3)), non-synergistic/additive (BMI, WHR, DM, glucose, insulin, HDL, HDL(2)) and indeterminate (apoA-I and TRIG) associations. If confirmed, these results may help better define the public health burden of smoking on CVD risk and identify links between etiologic factors and biologic mechanisms, where synergistic associations highlight joint impacts and non-synergistic associations suggest distinct contributions from each factor.

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  190. Similarities and differences between coronary heart disease and stroke in the associations with cardiovascular risk factors: The Japan Collaborative Cohort Study Reviewed International journal

    Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Kentaro Yamashita, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Chaochen Wang, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi

    ATHEROSCLEROSIS   Vol. 261   page: 124 - 130   2017.6

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    Background and aims: Coronary heart disease (CHD) and stroke have common risk factors, but some of these differ in the magnitude or direction of associations between CHD and stroke. We assessed whether the impact of each risk factor differed between CHD and stroke mortality in Asians.
    Methods: In total, 104 910 subjects aged 40-79 years without histories of cancer, CHD and stroke at baseline were followed between 1988 and 2009. Competing- risks analysis was used to test for differences in the associations of each risk factor with two endpoints (CHD and stroke). Population attributable fractions (PAFs) were also calculated for these endpoints to estimate the population impact of each risk factor.
    Results: During a median 19.1-year follow-up, 1554 died from CHD and 3163 from stroke. The association of hypertension with CHD was similar to that with stroke in terms of the magnitude and direction (multivariable-adjusted hazard ratio for CHD: 1.63 vs. stroke: 1.73 in men and 1.70 vs. 1.66 in women). Conversely, the magnitude of these associations differed for smoking (CHD: 1.95 vs. stroke: 1.23 in men and 2.45 vs. 1.35 in women) and diabetes (1.49 vs. 1.09 in men and 2.08 vs. 1.39 in women). The highest PAF for CHD was caused by smoking in men and by hypertension in women; that for stroke was caused by hypertension in both sexes.
    Conclusions: Hypertension associations and PAFs were consistent between CHD and stroke, but not for other risk factors. These findings may be useful to optimize public health intervention strategies. (C) 2017 Elsevier B.V. All rights reserved.

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  191. Descriptive Epidemiology of Hypertension and Its Association With Obesity: Based on the WHO STEPwise Approach to Surveillance in Palau Reviewed International coauthorship International journal

    Chaochen Wang, Chifa Chiang, Hiroshi Yatsuya, Esayas Haregot Hilawe, Edolem Ikerdeu, Kaori Honjo, Takashi Mita, Renzhe Cui, Yoshihisa Hirakawa, Sherilynn Madraisau, Hiroyasu Iso, Atsuko Aoyama

    ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH   Vol. 29 ( 4 ) page: 278 - 287   2017.5

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    The rise of noncommunicable diseases is a serious health burden for Palau. This study described the prevalence of hypertension, and assessed its association with obesity. Surveys following the WHO STEPwise approach to surveillance were conducted in 2529 adults. Multivariate prevalence ratios (PR) of hypertension for body mass index (BMI) categories were calculated by logistic regression models using conditional standardization procedure. Age- and sex-specified analyses were performed. Overall prevalence of obesity and hypertension were 40.4% and 46.8%, respectively. Prevalence of hypertension was positively associated with BMI. However, overweight men had as high prevalence of hypertension as the obese (multivariable-adjusted PR was 1.84 for overweight and 1.91 for obese compared with nonoverweight). The association between hypertension and BMI was similar across age groups. The prevalence of hypertension in women increased gradually with the increase of BMI whereas that in men reached a plateau already in the overweight.

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  192. Disparity in metabolic risk factors of non-communicable diseases between Palauans and Filipinos living in Palau Reviewed International coauthorship International journal

    Ayaka Osako, Chifa Chiang, Kana Ito, Hiroshi Yatsuya, Esayas Haregot Hilawe, Edolem Ikerdeu, Kaori Honjo, Takashi Mita, Renzhe Cui, Yoshihisa Hirakawa, Sherilynn Madraisau, Gregorio Ngirmang, Hiroyasu Iso, Atsuko Aoyama

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page: 157 - 165   2017.5

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    Non-communicable diseases have been recognized as a serious threat to public health in Palau. To tackle the problem, different strategies might be necessary for populations with different ethnic backgrounds. This study aims to find the differences in the prevalence of metabolic risk factors of non-communicable diseases between Palauans and Filipinos living in Palau, and examine possible determinants of the differences. We selected data of 2,032 participants, including native Palauans and Filipinos, from the Palau STEPS Survey 2011-2013 for this study. Logistic regression models were used to inspect the association of each metabolic risk factor with ethnicity by calculating odds ratios adjusted for potential confounding factors. Palauans had higher age-standardized prevalence of overweight or obesity (84% vs. 45%), hypertension (50% vs. 38%) and diabetes (19% vs. 13%) than Filipinos. However, after adjusting for BMI and various lifestyle related factors, there are no statistical significant differences in the prevalence of hypertension and diabetes between these two ethnic groups. Palauan men were less likely to have elevated total cholesterol, especially after adjusting for BMI (odds ratio=0.55, 95% confidence interval: 0.33-0.91), while Palauan women were more likely to have elevated triglycerides than their Filipino counterparts (odds ratio=1.45, 95% confidence interval: 1.02-2.06). Our findings suggested that Palauans' higher BMI distribution might be able to explain their higher prevalence of hypertension and partially explain their higher diabetes prevalence. Palauans were not consistently more likely to have all metabolic risk factors, namely dyslipidemia were less likely to be observed in Palauan men.

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  193. Passive smoking and chronic obstructive pulmonary disease mortality: findings from the Japan collaborative cohort study Reviewed International journal

    Shigekazu Ukawa, Akiko Tamakoshi, Hiroshi Yatsuya, Kazumasa Yamagishi, Masahiko Ando, Hiroyasu Iso

    INTERNATIONAL JOURNAL OF PUBLIC HEALTH   Vol. 62 ( 4 ) page: 489 - 494   2017.5

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    To elucidate the association between passive smoking at home and chronic obstructive pulmonary disease (COPD) mortality via a large-scale nationwide cohort study in Japan.
    Never smokers (n = 34,604) aged 40-79 years at baseline (1988-1990; 4884 men, 29,720 women) were included in the analysis. Passive smoking at home was measured based on self-reported frequency of weekly exposure to passive smoking at home. An inverse probability of treatment-weighted competing risk model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for COPD mortality.
    During a median follow-up of 16.4 years, 33 participants (10 men, 23 women) died of COPD. The HR for participants exposed to passive smoking at home ae&lt;currency&gt;4 days per week or those who had almost daily exposure to passive smoking at home had a significantly increased risk of COPD mortality (HR 2.40, 95% CI 1.39-4.15, HR 2.88, 95% CI 1.68-4.93, respectively).
    The present findings suggest that avoiding passive smoking at home may be beneficial for preventing death due to COPD among never smokers.

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  194. Increased airway hyperresponsiveness to adenosine in patients with aspirin intolerant asthma Reviewed International journal

    Sumito Isogai, Yoshikazu Niwa, Hiroshi Yatsuya, Masamichi Hayashi, Naoki Yamamoto, Takuya Okamura, Tomoyuki Minezawa, Yasuhiro Goto, Teppei Yamaguchi, Tomoko Takeyama, Yosuke Sakakibara, Sayako Morikawa, Tomoya Horiguchi, Yusuke Gotoh, Yuki Mieno, Sakurako Uozu, Toru Nakanishi, Mitsushi Okazawa, Hiroki Sakakibara, Kazuyoshi Imaizumi

    ALLERGOLOGY INTERNATIONAL   Vol. 66 ( 2 ) page: 360 - 362   2017.4

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  195. Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers' Cohort Study Reviewed International journal

    Y. Zhang, H. Yatsuya, Y. Li, C. Chiang, Y. Hirakawa, N. Kawazoe, K. Tamakoshi, H. Toyoshima, A. Aoyama

    NUTRITION & DIABETES   Vol. 7 ( 3 ) page: e252   2017.3

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    OBJECTIVE: This study aims to investigate the association of long-term weight-change slopes, weight fluctuation and the risk of type 2 diabetes mellitus (T2DM) in middle-aged Japanese men and women.
    METHODS: A total of 4234 participants of Aichi Workers' Cohort Study who were aged 35-66 years and free of diabetes in 2002 were followed through 2014. Past body weights at the ages of 20, 25, 30, 40 years, and 5 years before baseline as well as measured body weight at baseline were regressed on the ages. Slope and root-mean-square-error of the regression line were obtained and used to represent the weight changes and the weight fluctuation, respectively. The associations of the weight-change slopes and the weight fluctuation with incident T2DM were estimated by Cox proportional hazards models.
    RESULTS: During the median follow-up of 12.2 years, 400 incident cases of T2DM were documented. After adjustment for baseline overweight and other lifestyle covariates, the weight-change slopes were significantly associated with higher incidence of T2DM (hazard ratio (HR): 1.80, 95% confident interval (CI): 1.17-2.77 for men; and HR: 2.78, 95% CI: 1.07-7.23 for women), while the weight fluctuation was not (HR: 1.08, 95% CI: 1.00-1.18 for men and HR: 1.02, 95% CI: 0.84-1.25 for women).
    CONCLUSIONS: Regardless of the presence of overweight, the long-term weight-change slopes were significantly associated with the increased risk of T2DM; however, the weight fluctuation was not associated with the risk of T2DM in middle-aged Japanese men and women.

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  196. Daily Walking Time and Pneumonia Mortality Among Elderly With/Without Medical History of Myocardial Infarction or Stroke Reviewed

    Ukawa Shigekazu, Zhao Wenjing, Yatsuya Hiroshi, Yamagishi Kazumasa, Iso Hiroyasu, Tamakoshi Akiko

    CIRCULATION   Vol. 135   2017.3

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  197. A Point-based Prediction Model for Predicting 10-year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study Reviewed

    Yuanying Li, Hiroshi Yatsuya, Yoshihisa Hirakawa, Atsuhiko Ota, Masaaki Matsunaga, Hilawe Esayas Haregot, Chifa Chiang, Yan Zhang, Koji Tamakoshi, Hideaki Toyoshima, Atsuko Aoyama

    CIRCULATION   Vol. 135   2017.3

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  198. Daily Walking Time and Pneumonia Mortality Among Elderly With/Without Medical History of Myocardial Infarction or Stroke Reviewed

    Shigekazu Ukawa, Wenjing Zhao, Hiroshi Yatsuya, Kazumasa Yamagishi, Hiroyasu Iso, Akiko Tamakoshi

    CIRCULATION   Vol. 135   2017.3

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  199. No modifying effect of education level on the association between lifestyle behaviors and cardiovascular mortality: the Japan Collaborative Cohort Study Reviewed International journal

    Eri Eguchi, Hiroyasu Iso, Kaori Honjo, Hiroshi Yatsuya, Akiko Tamakoshi

    SCIENTIFIC REPORTS   Vol. 7   page: 39820   2017.1

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    We examined the effect of education level on the association between healthy lifestyle behaviors and cardiovascular mortality in the Japanese population. A total of 42,647 community-based men and women aged 40-79 years were enrolled at baseline (1988-1990), followed through 2009. The components of the healthy lifestyle score included the intake of fruits, fish, and milk; body mass index; exercise; avoidance of smoking; moderate alcohol intake; and moderate sleep duration. During the 19.3 years of follow-up, 8,314 all-cause and 2,377 total cardiovascular mortality cases were noted. Inverse associations were observed between healthy lifestyle scores and total cardiovascular disease (CVD) for both the lower and higher education level groups. Multivariable hazard ratios (95% confidence interval) for CVD mortality from the highest to the lowest healthy lifestyle scores, and the population attributable fraction (95% CIs) without healthy lifestyle scores of 7-8 were 0.51 (0.33-0.52) and 42% (24-58%), and 0.38 (0.27-0.47) and 55% (36-69%) for the higher and lower education levels, respectively. Our findings suggest that the association between higher CVD mortality and lower education level can be explained by the individuals' lower adherence to a healthy lifestyle; hence, lifestyle modification would be beneficial for the prevention of cardiovascular mortality, irrespective of the education level.

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  200. Risk Factor of Cardiovascular Disease Among Older Individuals Reviewed International journal

    Hiroshi Yatsuya, Masaaki Matsunaga, Yuanying Li, Atsuhiko Ota

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   Vol. 24 ( 3 ) page: 258 - 261   2017

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  201. Population profile and residential environment of an urban poor community in Dhaka, Bangladesh Reviewed International coauthorship International journal

    Md Khalequzzaman, Chifa Chiang, Bilqis Amin Hoque, Sohel Reza Choudhury, Saika Nizam, Hiroshi Yatsuya, Akiko Matsuyama, Yoshihisa Hirakawa, Syed Shariful Islam, Hiroyasu Iso, Atsuko Aoyama

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   Vol. 22 ( 1 ) page: 1   2017

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    Objectives: A population survey was conducted in an urban shantytown in Bangladesh, as a baseline study of future epidemiological studies. This paper aims to describe the findings of the study, including the population profile and residential environment of the urban poor.
    Methods: We conducted a complete count household survey in an urban poor community in Dhaka. Using a brief structured questionnaire in Bengali language, trained interviewers visited each household and asked questions such as: duration of residence; ownership of house, toilet and kitchen; water supply; number of family members; age, sex, education, occupation, tobacco use, and history of diseases of each family member.
    Results: We found that there were 8604 households and 34,170 people in the community. Average number of household members was 4.0. Most people had access to safe water, but only 16% lived in the house with a toilet. Based on the proxy indicators of household wealth levels, we identified that about 39% were relatively well-off, while the rest were very poor. Tobacco use was prevalent in men regardless of age and in women aged over 35 years. Prevalence of self-reported hypertension and diabetes was slightly higher in women than in men, although over 70% of the respondents didn't know if they had such diseases. Incidences of diarrhea in the last one month were relatively low.
    Conclusions: The study showed population profile and sanitation environment in an urban poor community by a complete count survey. We expect the study to serve as a baseline for future epidemiological studies.

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  202. Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN) Reviewed

    Yoichiro Hirakawa, the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN), Toshiharu Ninomiya, Yutaka Kiyohara, Yoshitaka Murakami, Shigeyuki Saitoh, Hideaki Nakagawa, Akira Okayama, Akiko Tamakoshi, Kiyomi Sakata, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, Yutaka Imai, Takayoshi Ohkubo, Fujiko Irie, Hiroyasu Iso, Akihiko Kitamura, Takeo Nakayama, Toshimi Sairenchi, Ichiro Tsuji, Michiko Yamada, Masahiko Kiyama, Yoshihiro Miyamoto, Shizukiyo Ishikawa, Hiroshi Yatsuya

    Journal of Epidemiology   Vol. 27 ( 3 ) page: 123 - 129   2017

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    Background: Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in the elderly, remains unclear in non-Western populations. Methods: A pooled analysis was conducted using 8 cohort studies (mean follow-up period, 10.3 years) in Japan, combining the data from 38,854 individual participants without history of cardiovascular disease. In all, 1867 of the participants had diabetes, defined based on the 1998 World Health Organization criteria. The association between diabetes and the risk of death from cardiovascular disease, coronary heart disease (CHD), and stroke was estimated using a stratified Cox model, accounting for variability of baseline hazard functions among cohorts. Results: During the follow-up, 1376 subjects died of cardiovascular disease (including 268 of coronary heart disease and 621 of stroke). Diabetes was associated with an increased risk of cardiovascular death after multivariable adjustment (hazard ratio [HR] 1.62
    95% confidence interval [CI], 1.35-1.94). Similarly, diabetes was a risk factor for CHD (HR 2.13
    95% CI, 1.47-3.09) and stroke (HR 1.40
    95% CI, 1.05-1.85). In the age-stratified analysis of the risk of cardiovascular death, the relative effects of diabetes were consistent across age groups (p for heterogeneity = 0.18), whereas the excess absolute risks of diabetes were greater in participants in their 70s and 80s than in younger subjects. Conclusions: The management of diabetes is important to reduce the risk of death from cardiovascular disease, not only in midlife but also in late life, in the Japanese population.

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  203. Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study Reviewed

    Yamagishi K, Iso H, Yatsuya H, Tanabe N, Date C, Kikuchi S, Yamamoto A, Inaba Y, Tamakoshi A; JACC Study Group.

    Am J Clin Nutr   Vol. 92 ( 4 ) page: 759-765   2010.10

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  204. Sex-Specific HDL Cholesterol Changes With Weight Loss and Their Association With Anthropometric Variables: The LIFE Study Reviewed International coauthorship

    Yatsuya H, Jeffery RW, Erickson DJ, Welsh EM, Flood AP, Jaeb MA, Laqua PS, Mitchell NR, Langer SL, Levy RL

    Obesity (Silver Spring)   Vol. Epub   2010.9

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  205. Associations of obesity measures with subtypes of ischemic stroke in the ARIC Study. Reviewed International coauthorship

    Yatsuya H, Yamagishi K, North KE, Brancati FL, Stevens J, Folsom AR; ARIC Study Investigators.

    J Epidemiol   Vol. 20 ( 5 ) page: 347-354   2010.9

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  206. Risk of incident cardiovascular disease among users of smokeless tobacco in the Atherosclerosis Risk in Communities (ARIC) study. Reviewed International coauthorship

    Yatsuya H, Folsom AR; ARIC Investigators.

    Am J Epidemiol   Vol. 172 ( 5 ) page: 600-605   2010.9

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  207. Body mass index and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanese cohorts using individual data. Reviewed

    Yatsuya H, Toyoshima H, Yamagishi K, Tamakoshi K, Taguri M, Harada A, Ohashi Y, Kita Y, Naito Y, Yamada M, Tanabe N, Iso H, Ueshima H; Japan Arteriosclerosis Longitudinal Study (JALS) group.

    Circ Cardiovasc Qual Outcomes.   Vol. 3 ( 5 ) page: 498-505   2010.9

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  208. Maintenance-tailored therapy vs. standard behavior therapy for 30-month maintenance of weight loss. Reviewed International coauthorship

    Levy RL, Jeffery RW, Langer SL, Graham DJ, Welsh EM, Flood AP, Jaeb MA, Laqua PS, Finch EA, Hotop AM, Yatsuya H.

    Prev Med   Vol. Epub   2010.9

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  209. Incidence of metabolic syndrome according to combinations of lifestyle factors among middle-aged Japanese male workers. Reviewed

    Li Y, Yatsuya H, Iso H, Tamakoshi K, Toyoshima H.

    Prev Med   Vol. 51 ( 2 ) page: 118-122   2010.8

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  210. Retinal microvascular abnormalities and risk of lacunar stroke: Atherosclerosis Risk in Communities Study Reviewed International coauthorship

    Yatsuya H, Folsom AR, Wong TY, Klein R, Klein BE, Sharrett AR; ARIC Study Investigators.

    Stroke   Vol. 41 ( 7 ) page: 1349-1355   2010.7

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  211. Demographic and cardiovascular risk factors modify association of fasting insulin with incident coronary heart disease and ischemic stroke (from the Atherosclerosis Risk In Communities Study). Reviewed International coauthorship

    Rasmussen-Torvik LJ, Yatsuya H, Selvin E, Alonso A, Folsom AR.

    Am J Cardiol   Vol. 105 ( 10 ) page: 1420-1425   2010.5

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  212. Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. Reviewed

    Muramatsu T, Yatsuya H, Toyoshima H, Sasaki S, Li Y, Otsuka R, Wada K, Hotta Y, Mitsuhashi H, Matsushita K, Murohara T, Tamakoshi K.

    Prev Med.   Vol. 50 ( 5-6 ) page: 272-276   2010.5

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  213. Race- and Sex-Specific Associations of Obesity Measures With Ischemic Stroke Incidence in the Atherosclerosis Risk in Communities (ARIC) Study Reviewed International coauthorship

    Yatsuya H, Folsom AR, Yamagishi K, North KE, Brancati FL, Stevens J; for the ARIC Study Investigators

    Stroke   Vol. 41 ( 3 ) page: 417-425   2010.3

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    BACKGROUND AND PURPOSE: Studies have suggested differences in the association between obesity and ischemic stroke in black versus white populations. In this study, we explored ischemic stroke risk in relation to a variety of obesity measures by sex and race. METHODS: Using data from the Atherosclerosis Risk in Communities Study, we obtained information on body mass index, waist circumference, and waist-to-hip ratio from 13 549 black and white participants who were aged 45 to 65 years between 1987 and 1989. All were free of cardiovascular disease and cancer at baseline. Incident strokes over a median follow-up of 16.9 years were ascertained from hospital records. RESULTS: Although crude incidence rates of ischemic stroke varied more than 3-fold by race and sex, the relationship between higher measures of obesity and ischemic stroke risk was positive and linear across all groups. The crude incidence of ischemic stroke was 1.2 per 1000 person-years for white women with the lowest body mass index, ranging up to 8.0 per 1000 person-years for black men with the highest body mass index. Hazard ratios for the highest versus lowest quintile of body mass index, waist circumference, and waist-to-hip ratio ranged from 1.43 to 3.19, indicating increased stroke risk associated with obesity, however it was measured, even after adjustment for potential confounders. Additional adjustment for factors that may mediate the relationship, such as diabetes and hypertension, significantly attenuated the associations, suggesting that these factors may explain much of the stroke risk associated with obesity. CONCLUSIONS: Degree of obesity, defined by body mass index, waist circumference, or waist-to-hip ratio, was a significant risk factor for ischemic stroke regardless of sex or race.

  214. Daytime napping and mortality, with a special reference to cardiovascular disease: the JACC study Reviewed

    Tanabe N, Iso H, Seki N, Suzuki H, Yatsuya H, Toyoshima H, Tamakoshi A; for the JACC Study Group

    Int J Epidemiol   Vol. 39 ( 1 ) page: 233-243   2010.2

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  215. BMI and all-cause mortality among Japanese older adults: findings from the Japan collaborative cohort study. Reviewed

    Tamakoshi A, Yatsuya H, Lin Y, Tamakoshi K, Kondo T, Suzuki S, Yagyu K, Kikuchi S; JACC Study Group

    Obesity (Silver Spring)   Vol. 18 ( 2 ) page: 362-369   2010.2

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  216. Vaginal douching in Cambodian women: its prevalence and association with vaginal candidiasis Reviewed International coauthorship

    Heng LS, Yatsuya H, Morita S, Sakamoto J

    J Epidemiol   Vol. 20 ( 1 ) page: 70-76   2010

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  217. Changes in C-reactive protein during weight loss and the association with changes in anthropometric variables in men and women: LIFE Study. Reviewed International coauthorship

    Yatsuya H, Jeffery RW, Langer SL, Mitchell N, Flood AP, Welsh EM, Jaeb MA, Laqua PS, Crowell M, Levy RL

    Int J Obes (Lond).   Vol. Epub   2010

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  218. Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2. Reviewed

    Ito E, Saito K, Yatsuya H, Nagatani T, Otsuka G

    Neurosurg Rev   Vol. 32 ( 4 ) page: 425-433   2009.10

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  219. Changes in activities of dail living, physical fitness, and depressive symptoms after six-month periodic well-rounded exercise programs for older adults living in nursing homes or special nursing facilities Reviewed

    Ouyang P, Yatsuya H, Toyoshima H, Otsuka R, Wada K, Matsushita K, Ishikawa M, Lee Y, Hotta Y, Mitsuhashi H, Muramatsu T, Kasuga N, Tamakoshi K

    Nagoya J Med Sci   Vol. 71 ( 3-4 ) page: 115-126   2009.9

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  220. Multilevel analyses of effects of variation in body mass index on serum lipid concentrations in middle-aged Japanese men. Reviewed

    Kondo T, Kimata A, Yamamoto K, Ueyama S, Ueyama J, Yatsuya H, Tamakoshi K, Hori Y

    Nagoya J Med Sci   Vol. 71 ( 1-2 ) page: 19-28   2009.2

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  221. Upper airway morphology in patients with obstructive sleep apnea syndrome: Effects of lateral positioning. Reviewed

    Soga T, Nakata S, Yasuma F, Noda A, Sugiura T, Yatsuya H, Koike Y, Ozaki N, Nakashima T.

    Auris Nasus Larynx   Vol. 36 ( 3 ) page: 305-309   2009.1

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  222. An influence of Interferon-gamma gene polymorphisms on treatment response to tuberculosis in Japanese population. Reviewed

    Shibasaki M, Yagi T, Yatsuya H, Okamoto M, Nishikawa M, Baba H, Hashimoto N, Senda K, Kawabe T, Nakashima K, Imaizumi K, Shimokata K, Hasegawa Y

    J Infect   Vol. 58 ( 6 ) page: 467-469   2009.1

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  223. Uric Acid and left ventricular hypertrophy in Japanese men. Reviewed

    Mitsuhashi H, Yatsuya H, Matsushita K, Zhang H, Otsuka R, Muramatsu T, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H, Tamakoshi K.

    Circ J   Vol. 73 ( 4 ) page: 667-672   2009

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  224. Group education with personal rehabilitation for idiopathic Parkinson's disease. Reviewed International coauthorship

    Guo L, Jiang Y, Yatsuya H, Yoshida Y, Sakamoto J.

    Can J Neurol Sci   Vol. 36 ( 1 ) page: 51-59   2009

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  225. Effect of the interaction between mental stress and eating pattern on body mass index gain in healthy Japanese male workers. Reviewed

    Toyoshima H, Masuoka N, Hashimoto S, Otsuka R, Sasaki S, Tamakoshi K, Yatsuya H.

    J Epidemiol   Vol. 19 ( 2 ) page: 88-93   2009

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  226. Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: comparison of leptin and adiponectin. Reviewed

    Sugiura K, Tamakoshi K, Yatsuya H, Otsuka R, Wada K, Matsushita K, Kondo T, Hotta Y, Mitsuhashi H, Murohara T, Toyoshima H.

    Int J Cardiol   Vol. 130 ( 2 ) page: 159-164   2008

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  227. Effect of physical activity on breast cancer risk: findings of the Japan collaborative cohort study. Reviewed

    Suzuki S, Kojima M, Tokudome S, Mori M, Sakauchi F, Fujino Y, Wakai K, Lin Y, Kikuchi S, Tamakoshi K, Yatsuya H, Tamakoshi A; Japan Collaborative Cohort Study Group.

    Cancer Epidemiol Biomarkers Prev   Vol. 17 ( 12 ) page: 3396-3401   2008

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  228. Development and validity of the Japanese version of body shape silhouette: relationship between self-rating silhouette and measured body mass index. Reviewed

    Nagasaka K, Tamakoshi K, Matsushita K, Toyoshima H, Yatsuya H.

    Nagoya J Med Sci   Vol. 70 ( 3-4 ) page: 89-96   2008

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  229. Self-reported medical history was generally accurate among Japanese workplace population. Reviewed

    Wada K, Yatsuya H, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Tamakoshi K.

    J Clin Epidemiol   Vol. 62 ( 3 ) page: 306-313   2008

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  230. Having more healthy practice was associated with low white blood cell counts in middle-aged Japanese male and female workers. Reviewed

    Otsuka R, Tamakoshi K, Wada K, Matsushita K, Ouyang P, Hotta Y, Takefuji S, Mitsuhashi H, Toyoshima H, Shimokata H, Yatsuya H.

    Ind Health   Vol. 46 ( 4 ) page: 341-347   2008

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  231. TH1/TH2 immune response in lung fibroblasts in interstitial lung disease. Reviewed

    Sumida A, Hasegawa Y, Okamoto M, Hashimoto N, Imaizumi K, Yatsuya H, Yokoi T, Takagi K, Shimokata K, Kawabe T.

    Arch Med Res   Vol. 39 ( 5 ) page: 503-510   2008

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  232. Further inflammatory information on metabolic syndrome by adiponectin evaluation. Reviewed

    Int J Cardiol   Vol. 124 ( 3 ) page: 339-344   2008

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  233. Low leptin but high insulin resistance of smokers in Japanese men. Reviewed

    Hotta Y, Yatsuya H, Toyoshima H, Matsushita K, Mitsuhashi H, Takefuji S, Oiso Y, Tamakoshi K.

    Diabetes Res Clin Pract   Vol. 81 ( 3 ) page: 358-364   2008

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    We investigated the association between smoking and leptin, and to discuss their influence on diabetes in a large-scale study of Japanese men. METHODS: A cross-sectional study was carried out in 2002. The subjects were 2836 men aged 35-66. Smoking history was investigated in a self-administered questionnaire. Blood leptin, glucose and insulin were measured. RESULTS: Significant differences in leptin levels and homeostasis model assessment of insulin resistance (HOMA-IR) related to smoking status were observed (P=0.001 and P=0.008, respectively). The multivariate-adjusted geometric means of leptin in current, past and never smokers were 3.88, 4.08 and 4.12 ng/ml, respectively, while the means of HOMA-IR were 1.64, 1.61 and 1.49, respectively. The age-, body mass index-, and other lifestyle-adjusted prevalences of diabetes in current and never smokers were 9.2 and 4.7%, respectively. That of current smokers was significantly higher than in never smokers (P<0.001). The dose-dependent association found between the intensity of smoking and leptin levels in current smokers was statistically significant (P=0.030). CONCLUSIONS: The present finding may explain in part an association among smoking, leptin levels and diabetes. Smoking is one of the important modifiable risk factors for the prevention of diabetes.

  234. Association between low birth weight and elevated white blood cell count in adulthood within a Japanese population. Reviewed

    Wada K, Tamakoshi K, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Yatsuya H.

    Circ J   Vol. 72 ( 5 ) page: 757-763   2008

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  235. Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Reviewed

    Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Mori M, Tamakoshi A; Japan Collaborative Cohort Study Group for Evaluation of Cancer Risk.

    J Epidemiol   Vol. 18 ( 2 ) page: 77-83   2008

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  236. Eating fast leads to insulin resistance: findings in middle-aged Japanese men and women. Reviewed

    Otsuka R, Tamakoshi K, Yatsuya H, Wada K, Matsushita K, OuYang P, Hotta Y, Takefuji S, Mitsuhashi H, Sugiura K, Sasaki S, Kral JG, Toyoshima H.

    Prev Med   Vol. 46 ( 2 ) page: 154-159   2008

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  237. Smoking status and adiponectin in healthy Japanese men and women. Reviewed

    Takefuji S, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Matsushita K, Sugiura K, Hotta Y, Mitsuhashi H, Oiso Y, Toyoshima H.

    Prev Med   Vol. 45 ( 6 ) page: 471-475   2007.12

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  238. High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Yang PO, Otsuka R, Wada K, Mitsuhashi H, Hotta Y, Kondo T, Murohara T, Toyoshima H.

    Circ J   Vol. 71 ( 6 ) page: 820-825   2007

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  239. Risk factors for first acute myocardial infarction attack assessed by cardiovascular disease registry data in Aichi Prefecture. Reviewed

    Kondo Y, Toyoshima H, Yatsuya H, Hirose K, Morikawa Y, Ikedo N, Masui T, Tamakoshi K.

    Nagoya J Med Sci   Vol. 69 ( 3-4 ) page: 139-147   2007

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  240. A nested case-control study of stomach cancer incidence and serum superoxide dismutase activity in the Japan Collaborative Cohort study in Japan. Reviewed

    Pham TM, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Kubo T, Matsuda S, Yoshimura T; JACC Study Group.

    Cancer Detect Prev   Vol. 31 ( 6 ) page: 431-435   2007

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  241. Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities. Reviewed

    Ichihara M, Murakumo Y, Masuda A, Matsuura T, Asai N, Jijiwa M, Ishida M, Shinmi J, Yatsuya H, Qiao S, Takahashi M, Ohno K.

    Nucleic Acids Res   Vol. 35 ( 18 ) page: e123   2007

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  242. Pathophysiologic mechanisms of obesity and related metabolic disorders: an epidemiologic study using questionnaire and serologic biomarkers. Invited

    Yatsuya H.

    J Epidemiol   Vol. 17 ( 5 ) page: 141-146   2007

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  243. Reduction of inner retinal thickness in patients with autosomal dominant optic atrophy associated with OPA1 mutations. Reviewed

    Ito Y, Nakamura M, Yamakoshi T, Lin J, Yatsuya H, Terasaki H.

    Invest Ophthalmol Vis Sci   Vol. 48 ( 9 ) page: 4079-4086   2007

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  244. Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients. Reviewed

    Nihashi T, Yatsuya H, Hayasaka K, Kato R, Kawatsu S, Arahata Y, Iwai K, Takeda A, Washimi Y, Yoshimura K, Mizuno K, Kato T, Naganawa S, Ito K.

    Radiat Med   Vol. 25 ( 6 ) page: 255-262   2007

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  245. Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study. Reviewed

    Nishio K, Niwa Y, Toyoshima H, Tamakoshi K, Kondo T, Yatsuya H, Yamamoto A, Suzuki S, Tokudome S, Lin Y, Wakai K, Hamajima N, Tamakoshi A.

    Cancer Causes Control   Vol. 18 ( 8 ) page: 801-808   2007

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  246. High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Yang PO, Otsuka R, Wada K, Mitsuhashi H, Hotta Y, Kondo T, Murohara T, Toyoshima H.

      Vol. 71 ( 6 ) page: 820-825   2007

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  247. A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3. Reviewed

    Pham TM, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Matsuda S, Yoshimura T; JACC Study Group.

    Eur J Cancer   Vol. 43 ( 10 ) page: 1611-1616   2007

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  248. A new method of blood sampling reduces pain for newborn infants: a prospective, randomized controlled clinical trial. Reviewed

    Sato Y, Fukasawa T, Hayakawa M, Yatsuya H, Hatakeyama M, Ogawa A, Kuno K.

    Early Hum Dev   Vol. 83 ( 6 ) page: 389-394   2007

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  249. The transition to menopause reinforces adiponectin production and its contribution to improvement of insulin-resistant state. Reviewed

    Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Yang PO, Sugiura K, Hotta Y, Mitsuhashi H, Takefuji S, Kondo T, Toyoshima H.

    Clin Endocrinol (Oxf)   Vol. 66 ( 1 ) page: 65-71   2007

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  250. Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study). Reviewed

    Kondo T, Hori Y, Yatsuya H, Tamakoshi K, Toyoshima H, Nishino Y, Seki N, Ito Y, Suzuki K, Ozasa K, Watanabe Y, Ando M, Wakai K, Tamakoshi A.

    Cancer Causes Control   Vol. 18 ( 2 ) page: 229-234   2007

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  251. Psychological attitudes and risk of breast cancer in Japan: a prospective study. Reviewed

    Wakai K, Kojima M, Nishio K, Suzuki S, Niwa Y, Lin Y, Kondo T, Yatsuya H, Tamakoshi K, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; for the JACC Study Group.

    Cancer Causes Control   Vol. 18 ( 3 ) page: 259-267   2007

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  252. Psychological factors and insomnia among male civil servants in Japan. Reviewed

    Murata C, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Toyoshima H.

    Sleep Med   Vol. 8 ( 3 ) page: 209-217   2007

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  253. A nested case-control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3. Reviewed

    Pham TM, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Matsuda S, Yoshimura T; The JACC Study Group.

    Eur J Cancer   Vol. 43 ( 10 ) page: 1611-1616   2007

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  254. Impact of intensive-care-unit(ICU)-acquired ventilator-associated pneumonia(VAP) on hospital mortality: a matched-paired case-control study. Reviewed

    Uno H, Takezawa J, Yatsuya H, Suka M, Yoshida K.

    Nagoya J Med Sci   Vol. 69 ( 1-2 ) page: 29-36   2007

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  255. White blood cell count and risk of all-cause and cardiovascular mortality in nationwide sample of Japanese--results from the NIPPON DATA90. Reviewed

    Tamakoshi K, Toyoshima H, Yatsuya H, Matsushita K, Okamura T, Hayakawa T, Okayama A, Ueshima H; NIPPON DATA90 Research Group.

    Circ J   Vol. 71 ( 4 ) page: 479-485   2007

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  256. Adiponectin level and left ventricular hypertrophy in Japanese men. Reviewed

    Mitsuhashi H, Yatsuya H, Tamakoshi K, Matsushita K, Otsuka R, Wada K, Sugiura K, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H.

    Hypertension   Vol. 49 ( 6 ) page: 1448-1454   2007

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  257. Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Zhang H, Sugiura K, Kondo T, Murohara T, Toyoshima H.

    Atherosclerosis   Vol. 188   page: 184-189   2006.9

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  258. Perceived psychological stress and serum leptin concentrations in Japanese men. Reviewed

    Otsuka R, Yatsuya H, Tamakoshi K, Matsushita K, Wada K, Toyoshima H.

    Obesity (Silver Spring)   Vol. 14 ( 10 ) page: 1832-1838   2006

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  259. Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Zhang H, Sugiura K, Kondo T, Murohara T, Toyoshima H.

    Atherosclerosis   Vol. 188 ( 1 ) page: 184-189   2006

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  260. Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Takefuji S, Sugiura K, Kondo T, Murohara T, Toyoshima H.

    Arterioscler Thromb Vasc Biol   Vol. 26 ( 4 ) page: 871-876   2006

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  261. Birth weight and adult hypertension: cross-sectional study in a Japanese workplace population. Reviewed

    Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Yang PO, Sugiura K, Hotta Y, Mitsuhashi H, Kondo T, Toyoshima H.

    Circ J   Vol. 70 ( 3 ) page: 262-267   2006

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  262. Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring. Reviewed

    Wada K, Tamakoshi K, Yatsuya H, Otsuka R, Murata C, Zhang H, Takefuji S, Matsushita K, Sugiura K, Toyoshima H.

    Prev Med   Vol. 42 ( 5 ) page: 358-363   2006

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  263. Determinants of self-rated health: could health status explain the association between self-rated health and mortality? Reviewed

    Murata C, Kondo T, Tamakoshi K, Yatsuya H, Toyoshima H.

    Arch Gerontol Geriatr   Vol. 43 ( 3 ) page: 369-380   2006

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  264. Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren. Reviewed

    Fujii C, Sakakibara H, Kondo T, Yatsuya H, Tamakoshi K, Toyoshima H.

    J Epidemiol   Vol. 16 ( 2 ) page: 64-70   2006

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  265. Low birth weight is associated with reduced adiponectin concentration in adult. Reviewed

    Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Sugiura K, Kondo T, Toyoshima H.

    Ann Epidemiol   Vol. 16 ( 9 ) page: 669-674   2006

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  266. Eating fast leads to obesity: findings based on self-administered questionnaires among middle-aged Japanese men and women. Reviewed

    Otsuka R, Tamakoshi K, Yatsuya H, Murata C, Sekiya A, Wada K, Zhang HM, Matsushita K, Sugiura K, Takefuji S, OuYang P, Nagasawa N, Kondo T, Sasaki S, Toyoshima H.

    Journal of Epidemiology   Vol. 16 ( 3 ) page: 117-124   2006

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  267. Factors associated with life space among community-living rural elders in Japan. Reviewed

    Murata C, Kondo T, Tamakoshi K, Yatsuya H, Toyoshima H.

    Public Health Nurs   Vol. 23 ( 4 ) page: 324-331   2006

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  268. Interleukin-8 gene polymorphism associated with susceptibility to non-cardia gastric carcinoma with microsatellite instability. Reviewed

    Shirai K, Ohmiya N, Taguchi A, Mabuchi N, Yatsuya H, Itoh A, Hirooka Y, Niwa Y, Mori N, Goto H.

    J Gastroenterol Hepatol   Vol. 21 ( 7 ) page: 1129-1135   2006

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  269. Seasonal variations of acute massive submacular haemorrhage associated with age-related macular degeneration. Reviewed

    Iguchi Y, Ito Y, Kikuchi M, Ishikawa K, Oshima H, Yatsuya H, Terasaki H.

    Br J Ophthalmol   Vol. 90 ( 10 ) page: 1256-1258   2006

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  270. Factors related to frequency of engaging in outside activities among elderly persons living an independent life at home. Reviewed

    Ishikawa M, Tamakoshi K, Yatsuya H, Suma K, Wada K, Otsuka R, Matsushita K, Zhang H, Murata C, Kondo T, Toyoshima H.

    Nagoya J Med Sci   Vol. 68 ( 3-4 ) page: 121-130   2006

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  271. HIV prevalence and factors associated with HIV infection among male injection drug users under 30: a cross-sectional study in Long An, Vietnam. Reviewed International coauthorship

    Tran TM, Nguyen HT, Yatsuya H, Hamajima N, Nishimura A, Ito K.

    BMC Public Health   Vol. 10 ( 6 ) page: 248   2006

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  272. A positive association between leptin and blood pressure of normal range in Japanese men. Reviewed

    Wada K, Yatsuya H, Tamakoshi K, Otsukai R, Fujii C, Matsushita K, Sugiura K, Toyoshima H.

    Hypertens Res   Vol. 29 ( 7 ) page: 485-492   2006

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  273. Serum levels of insulin-like growth factor I, II, and binding protein 3, transforming growth factor beta-1, soluble fas ligand and superoxide dismutase activity in stomach cancer cases and their controls in the JACC Study. Reviewed

    Yatsuya H, Toyoshima H, Tamakoshi K, Tamakoshi A, Kondo T, Hayakawa N, Sakata K, Kikuchi S, Hoshiyama Y, Fujino Y, Mizoue T, Tokui N, Yoshimura T; JACC Study Group.

    Journal of Epidemiology   Vol. 15 ( S2 ) page: S120-S125   2005

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    BACKGROUND: The prognosis of stomach cancer with advanced stage remains poor. New biomarkers of the disease that may contribute to establish the potential screening strategy would be of value for the early detection of individuals at high risk of the disease. METHODS: We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the Japan Collaborative Cohort (JACC) Study, to evaluate serum levels of insulin-like growth factor I, II, and binding protein 3 (IFG-I, IGF-II, and IGFBP-3), transforming growth factorbeta-1 (TGFbeta1), soluble fas (sFas) and superoxide dismutase activity (SOD) in 210 stomach cancer cases diagnosed in the JACC Study in relation to those levels in their 410 controls. RESULTS: Among 6 serum biomarkers tested for case-control differences, only sFas level in female stomach cancer cases was significantly higher than that of controls (2.22 pg/ml vs. 2.04 pg/mL, respectively; P=0.013 by two-way analysis of covariance controlling for matching variable). CONCLUSION: None of the biomarkers consistently predicted future risk of stomach cancer in both men and women in the present analysis. Serum sFas level in women, however, should be studied much more thoroughly whether it provides meaningful refinement of risk stratification, or it elucidate the mechanisms of tumorigenesis in women.

  274. Validity of self-reported height and weight in a Japanese workplace population. Reviewed

    Wada K, Tamakoshi K, Tsunekawa T, Otsuka R, Zhang H, Murata C, Nagasawa N, Matsushita K, Sugiura K, Yatsuya H, Toyoshima H.

    Int J Obes Relat Metab Disord   Vol. 29 ( 9 ) page: 1093-9   2005

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  275. Effects of social relationships on mortality among the elderly in a Japanese rural area: an 88-month follow-up study. Reviewed

    Murata C, Takaaki K, Hori Y, Miyao D, Tamakoshi K, Yatsuya H, Sakakibara H, Toyoshima H.

    J Epidemiol   Vol. 15 ( 3 ) page: 78-84   2005

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  276. Gender difference of sudden death Invited

    Tamakoshi K, Toyoshima H, Yatsuya H.

    Nippon Rinsho   Vol. 63 ( 7 ) page: 1284-8   2005

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    Language:Japanese  

  277. Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan. Reviewed

    Tamakoshi K, Toyoshima H, Wakai K, Kojima M, Suzuki K, Watanabe Y, Hayakawa N, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A.

    Oncology   Vol. 68 ( 4-6 ) page: 454-61   2005

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  278. Green tea and stomach cancer--a short review of prospective studies. Reviewed

    Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Yoshimura T; JACC Study Group.

    J Epidemiol   Vol. 15 ( S2 ) page: S109-12   2005

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  279. Cigarette smoking and mortality due to stomach cancer: findings from the JACC Study. Reviewed

    Fujino Y, Mizoue T, Tokui N, Kikuchi S, Hoshiyama Y, Toyoshima H, Yatsuya H, Sakata K, Tamakoshi A, Ide R, Kubo T, Yoshimura T; JACC Study Group.

    J Epidemiol   Vol. 15 ( S2 ) page: S113-S119   2005

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  280. Serum pepsinogen values and Helicobacter pylori status among control subjects of a nested case-control study in the JACC study. Reviewed

    Kikuchi S, Yagyu K, Obata Y, Yingsong L, Yatsuya H, Hoshiyama Y, Kondo T, Sakata K, Mizoue T, Tokui N, Fujino Y, Tamakoshi A, Toyoshima H, Ishibashi T, Hayakawa N, Yoshimura T; JACC Study Group.

    J Epidemiol   Vol. 15 ( S2 ) page: S126-S133   2005

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  281. Mortality and incidence rates of stomach cancer in the JACC Study. Reviewed

    J Epidemiol   Vol. 15 ( S2 ) page: S89-S97   2005

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  282. Dietary habits and stomach cancer risk in the JACC Study. Reviewed

    Tokui N, Yoshimura T, Fujino Y, Mizoue T, Hoshiyama Y, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Kubo T, Tamakoshi A; JACC Study Group.

    J Epidemiol   Vol. 15 ( S2 ) page: S98-S108   2005

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  283. Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Reviewed

    Wakai K, Tamakoshi K, Date C, Fukui M, Suzuki S, Lin Y, Niwa Y, Nishio K, Yatsuya H, Kondo T, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A; JACC Study Group.

    Cancer Sci   Vol. 96 ( 9 ) page: 590-599   2005

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  284. Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. Reviewed

    Niwa Y, Yatsuya H, Tamakoshi K, Nishio K, Kondo T, Lin Y, Suzuki S, Wakai K, Tokudome S, Yamamoto A, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

    J Obstet Gynaecol Res   Vol. 31 ( 5 ) page: 452-458   2005

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  285. Prospective study of alcohol consumption and breast cancer risk in Japanese women. Reviewed

    Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A.

    Int J Cancer   Vol. 116 ( 5 ) page: 779-83   2005

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  286. 出生時体重と成人期の生活習慣病との関連-胎児期起源仮説- Invited

    玉腰浩司、八谷寛、大塚礼、和田恵子、張恵明、豊嶋英明.

    現代医学   Vol. 52   page: 321-325   2005

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  287. 突然死と性差 Invited

    玉腰浩司、豊嶋英明、八谷寛.

    日本臨床   Vol. 63   page: 1284-1288   2005

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  288. 肥満の健康影響 Invited

    八谷寛、玉腰浩司、豊嶋英明.

    現代医学   Vol. 52   page: 521-526   2005

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  289. 肥満の科学的解明とエビデンスに基づいた対策・指導 Invited

    八谷寛、松下邦洋、玉腰浩司、大塚礼、和田恵子、豊嶋英明.

    産業医学レビュー   Vol. 18   page: 71-116   2005

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  290. 職域コホート男性における血清レプチン濃度と生活習慣との関連 Reviewed

      Vol. 63   page: 1284-1288   2005

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  291. Lack of an association between serum level of transforming growth factor beta -1 and stomach cancer risk in the JACC study. Reviewed

    Yatsuya H, Tamakoshi A, Tamakoshi K, Hoshiyama Y, Fujino Y, Tokui N, Mizoue T, Kikuchi S, Sakata K, Hayakawa N, Kondo T, Toyoshima H, Yoshimura T.

    Asian Pacific Journal of Cancer Prevention   Vol. 6 ( 2 ) page: 170-176   2005

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    Alterations in the serum concentration of transforming growth factor beta-1 (TGFbeta1) have been observed in gastric cancer patients. No study, however, has ever examined the association between the serum TGFbeta1 level and stomach cancer prospectively. We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the JACC Study to assess whether serum level of total TGFbeta1 is associated with a subsequent risk of stomach cancer. The concentration of serum TGFbeta1 in previously collected blood samples was analyzed by ELISA for 209 individuals in whom a diagnosis of stomach cancer was documented, and for 409 controls matched with them for gender, age and study area. Baseline blood levels of TGFbeta1 were not related to the risk of stomach cancer in either men or women, a finding unchanged even after adjustment for potential confounders. The multivariate-adjusted odds ratio of stomach cancer in men and women was 1.10 (95% CI, 0.82 to 1.48) and 1.09 (95% CI, 0.80 to 1.48), respectively, for each increase of 1 SD in the TGFbeta1 value. In conclusion, serum TGFbeta1 levels were not associated with increased risks of subsequent stomach cancer.

  292. Familial aggregation and coaggregation of history of hypertension and stroke. Reviewed

    Kondo T, Toyoshima H, Tsuzuki Y, Hori Y, Yatsuya H, Tamakoshi K, Tamakoshi A, Ohno Y; JACC Study Group.

    J Hum Hypertens   Vol. 19 ( 2 ) page: 119-25   2005

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  293. Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men. Reviewed

    Zhang H, Tamakoshi K, Yatsuya H, Murata C, Wada K, Otsuka R, Nagasawa N, Ishikawa M, Sugiura K, Matsushita K, Hori Y, Kondo T, Toyoshima H.

    Circ J   Vol. 69 ( 1 ) page: 13-8   2005

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  294. Impact of menstrual and reproductive factors on breast cancer risk in Japan: results of the JACC study. Reviewed

    Tamakoshi K, Yatsuya H, Wakai K, Suzuki S, Nishio K, Lin Y, Niwa Y, Kondo T, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; JACC Study Group.

    Cancer Sci   Vol. 96 ( 1 ) page: 57-62   2005

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  295. Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women. Reviewed

    Mabuchi T, Yatsuya H, Tamakoshi K, Otsuka R, Nagasawa N, Zhang H, Murata C, Wada K, Ishikawa M, Hori Y, Kondo T, Hashimoto S, Toyoshima H.

    Diabetes Metab Res Rev   Vol. 21 ( 5 ) page: 441-7   2005

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  296. Cigarette smoking and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort study. Reviewed

    Niwa Y, Wakai K, Suzuki S, Tamakoshi K, Lin Y, Yatsuya H, Kondo T, Nishio K, Yamamoto A, Tokudome S, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

    J Obstet Gynaecol Res   Vol. 31 ( 2 ) page: 144-51   2005

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  297. Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. Reviewed

    Niwa Y, Yatsuya H, Tamakoshi K, Nishio K, Kondo T, Lin Y, Suzuki S, Wakai K, Tokudome S, Yamamoto A, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

    J Obstet Gynaecol Res   Vol. 31 ( 5 ) page: 452-458   2005

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    Language:English   Publishing type:Research paper (scientific journal)  

  298. Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Reviewed

    Wakai K, Tamakoshi K, Date C, Fukui M, Suzuki S, Lin Y, Niwa Y, Nishio K, Yatsuya H, Kondo T, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A; JACC Study Group.

    Cancer Sci   Vol. 96 ( 9 ) page: 590-599   2005

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  299. Association of white blood cell count and clustered components of metabolic syndrome in Japanese men. Reviewed

    Nagasawa N, Tamakoshi K, Yatsuya H, Hori Y, Ishikawa M, Murata C, Zhang H, Wada K, Otsuka R, Mabuchi T, Kondo T, Toyoshima H.

    Circ J   Vol. 68 ( 10 ) page: 892-7   2004

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  300. 人間ドックの有効性と限界 Invited

    玉腰浩司, 八谷寛, 豊嶋英明.

    総合臨床   Vol. 53   page: 2435-2438   2004

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  301. 玉腰浩司,八谷寛,豊嶋英明. Invited

      Vol. 208   page: 229-230   2004

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  302. 肥満を伴った高脂血症患者に対する運動療法の効果に関する研究 行動医学的アプローチを用いた運動習慣の定着による動脈硬化促進要因の改善に関する研究 Invited

    下光輝一, 井上茂, 小田切優子, 高波嘉一, 豊嶋英明, 八谷寛, 玉腰浩司, 近藤高明, 井口ちよ

    医科学応用研究財団研究報告   Vol. 21   page: 215-223   2004

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  303. 日本人男性における血清レプチン濃度と5年間追跡後の体重変化. Invited

    八谷寛, 玉腰浩司, 大塚礼, 間淵智子, 和田恵子, 張恵明, 村田千代栄, 石川美由紀, 近藤高明, 豊嶋英明.

    健康医科学研究助成論文集   Vol. 19   page: 110-117   2004

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  304. 肥満者における心血管疾患発症の過剰リスクを説明する新しい軸-血清レプチン値と白血球数の関連- Invited

    八谷寛, 淵智子, 大塚礼, 和田恵子, 長澤伸江, 張恵明, 村田千代栄, 石川美由紀, 堀容子, 近藤高明, 玉腰浩司, 豊嶋英明.

    健康管理事業団研究助成論文集   Vol. 10   page: 19-25   2004

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  305. Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study. Reviewed

    Yatsuya H, Toyoshima H, Tamakoshi A, Kikuchi S, Tamakoshi K, Kondo T, Mizoue T, Tokui N, Hoshiyama Y, Sakata K, Hayakawa N, Yoshimura T; Japan Collaborative Cohort Study Group.

    British Journal of Cancer   Vol. 91 ( 5 ) page: 929-934   2004

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    We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58-16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.

  306. Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases. Reviewed

    Yatsuya H, Tamakoshi K, Hattori H, Otsuka R, Wada K, Zhang H, Mabuchi T, Ishikawa M, Murata C, Yoshida T, Kondo T, Toyoshima H.

    Circulation Journal   Vol. 68 ( 1 ) page: 11-16   2004

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    BACKGROUND: Phospholipid transfer protein (PLTP) can generate pre-beta high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease. METHODS AND RESULTS: Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized beta=0.395, -0.191, -0.064, and -0.064, respectively; R(2)=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95% confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke. CONCLUSIONS: The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.

  307. A nested case-control study of stomach cancer in relation to green tea consumption in Japan. Reviewed

    Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T; Japan Collaborative Cohort Study Group.

    Br J Cancer   Vol. 90 ( 1 ) page: 135-8   2004

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  308. A prospective study of body size and colon cancer mortality in Japan: The JACC Study. Reviewed

    Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

    Int J Obes Relat Metab Disord   Vol. 28 ( 4 ) page: 551-8   2004

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  309. A prospective study on the possible association between having children and colon cancer risk: findings from the JACC Study. Reviewed

    Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

    Cancer Sci   Vol. 95 ( 3 ) page: 243-7   2004

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  310. A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: findings from the JACC study. Reviewed

    Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A; JACC Study Group.

    Cancer Sci   Vol. 95 ( 7 ) page: 602-7   2004

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  311. Association of flatfoot with pain, fatigue and obesity in Japanese over sixties. Reviewed

    Otsuka R, Yatsuya H, Miura Y, Murata C, Tamakoshi K, Oshiro K, Nishio N, Ishikawa M, Zhang HM, Shiozawa M, Kobayashi A, Ito M, Hori Y, Kondo T, Toyoshima H.

    Nippon Koshu Eisei Zasshi   Vol. 50 ( 10 ) page: 988-98   2003.10

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  312. Effect of tactile interference stimulation of the ear in human primary somatosensory cortex: a magnetoencephalographic study. Reviewed

    Nihashi T, Kakigi R, Hoshiyama M, Miki K, Kajita Y, Yoshida J, Yatsuya H.

    Clin Neurophysiol   Vol. 114 ( 10 ) page: 1866-78   2003.10

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  313. Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Ishikawa M, Zhang H, Murata C, Otsuka R, Mabuchi T, Hori Y, Zhu S, Yoshida T, Toyoshima H.

    Int J Obes Relat Metab Disord   Vol. 27 ( 9 ) page: 1059-65   2003.9

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  314. Aggregation of stomach cancer history in parents and offspring in comparison with other sites. Reviewed

    Kondo T, Toyoshima H, Tsuzuki Y, Hori Y, Yatsuya H, Tamakoshi K, Tamakoshi A, Ohno Y, Kikuchi S, Sakata K, Hoshiyama Y, Hayakawa N, Tokui N, Mizoue T, Yoshimura T.

    Int J Epidemiol     page: 579-83   2003.8

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  315. Prospective study of screening for stomach cancer in Japan. Reviewed

    Mizoue T, Yoshimura T, Tokui N, Hoshiyama Y, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Fujino Y, Kaneko S; Japan Collaborative Cohort Study Group.

    Int J Cancer   Vol. 106 ( 1 ) page: 103-7   2003.8

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  316. The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Ishikawa M, Zhang H, Murata C, Otsuka R, Zhu S, Toyoshima H.

    Int J Obes Relat Metab Disord   Vol. 27 ( 4 ) page: 443-9   2003.4

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  317. U-shaped association between white blood cell count and fasting plasma glucose level. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Zhang H, Ishikawa M, Murata C, Otsuka R, Zhu S, Toyoshima H.

    Diabetes Care   Vol. 26 ( 3 ) page: 950   2003.3

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  318. The accuracy of long-term recall of past body weight in Japanese adult men. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Hirano T, Hori Y, Yoshida T, Toyoshima H.

    Int J Obes Relat Metab Disord   Vol. 27 ( 2 ) page: 247-52   2003.2

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  319. Gender and age differences in lifestyle factors related to hypertension in middle-aged civil service employees. Reviewed

    Hori Y, Toyoshima H, Kondo T, Tamakoshi K, Yatsuya H, Zhu S, Kawamura T, Toyama J, Okamoto N.

    J Epidemiol   Vol. 13 ( 1 ) page: 38-47   2003.1

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  320. Reproducibility and validity of a simple checklist-type questionnaire for food intake and dietary behavior. Reviewed

    Yatsuya H, Ohwaki A, Tamakoshi K, Wakai K, Koide K, Otsuka R, Mabuchi T, Murata C, Zhang H, Ishikawa M, Kondo T, Toyoshima H.

    Journal of Epidemiology   Vol. 13 ( 5 ) page: 235-245   2003

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    BACKGROUND: A simple, reliable, and valid food questionnaire is needed in clinical dietary assessments, community health education, and multi-purpose epidemiologic studies to obtain a crude measure of dietary intake. METHODS: To assess the validity and reproducibility of a simple 4-point scale food intake and behavior checklist, it was compared to two 3-day weighed dietary records. The FBC was administered to 47 students of a dietician course and their parents (n = 94) over a 9-month interval to assess the reproducibility. The mean intakes of selected food groups assessed by the two dietary records completed between food intake and behavior checklists were compared to the responses to the food intake and behavior checklist to assess its validity. RESULTS: The kappa statistics for reproducibility ranged from 0.25 for confectionaries to 0.63 for a preference for fatty foods (median, 0.39). There was a reasonable level of correlation between the dietary record and the food intake and behavior checklist in the intake of eggs, milk, and fruits (r = 0.53, 0.56, and 0.50, respectively). There was a weaker but still significant correlation in the intake of vegetables, and alcohol (r = 0.31 and 0.45, respectively). No significant correlation was observed in the intake of meat, fish, confectionaries, and soft drinks. However, those who reported consuming mainly fish rather than meat were found to eat significantly less meat and animal fat. Similarly, those who did not prefer fatty foods consumed significantly less meat, animal fat, and polyunsaturated fatty acids. CONCLUSIONS: This simple food checklist was useful in collecting data on egg, milk, and fruit consumption. Assessing intake frequency of vegetables, meat or fish with the FBC may be useful in screening high- or low-intake individuals.

  321. クリティカルパスの実際: 高血圧クリティカルパス Invited

    堀容子, 齊藤郁夫, 鈴木一夫, 長谷川敏彦, 星野純子, 八谷寛, 玉腰浩司, 近藤高明, 豊嶋英明, 村地俊二.

    成人病と生活習慣病   Vol. 33   page: 687-692   2003

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  322. わが国における心筋梗塞と脳卒中 疫学的検討:高脂血症の疫学と心筋梗塞,脳卒中 Invited

    玉腰浩司, 八谷寛, 近藤高明, 豊嶋英明.

    循環器科   Vol. 54   page: 372-379   2003

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  323. 肥満と動脈硬化:肥満度の指標" Invited

    八谷寛, 玉腰浩司, 近藤高明, 豊嶋英明.

    動脈硬化予防   Vol. 2   page: 17-23   2003

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  324. 後期高齢者における転倒関連要因についての検討 サテライト型デイサービス利用者を対象として Reviewed

    堀容子, 近藤高明, 玉腰浩司, 八谷寛, 滝益栄, 小林督子, 北澤百合子, 代田妙子, 豊嶋英明.

    日本赤十字愛知短期大学紀要   Vol. 14   page: 139-146   2003

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  325. 地域在住高齢者における扁平足と足の自覚症状,及び肥満との関連 Reviewed

    大塚礼, 八谷寛, 三浦弥生, 村田千代栄, 玉腰浩司, 大城宏治, 西尾直樹, 石川美由紀, 張恵明, 塩澤まゆみ, 小林あゆみ, 伊藤美果, 堀容子, 近藤高明, 豊嶋英明.

    日本公衆衛生雑誌   Vol. 50   page: 988-998   2003

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  326. Association between weight fluctuation and fasting insulin concentration in Japanese men. Reviewed

    Yatsuya H, Tamakoshi K, Yoshida T, Hori Y, Zhang H, Ishikawa M, Zhu S, Kondo T, Toyoshima H.

    International Journal of Obesity and Related Metabolic Disorders   Vol. 27 ( 4 ) page: 478-483   2003

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    OBJECTIVE: To investigate whether long-term weight fluctuation is associated with the fasting serum insulin concentration. DESIGN AND SUBJECTS: Weight histories of 1932 male Japanese workers aged 40-59 y were analyzed in relation to their current fasting serum insulin concentration. MEASUREMENTS: Individual weight fluctuation was calculated by root mean square error (RMSE) along the linear regression line of weight measured at five to six different ages. RESULTS: The mean RMSE and fasting insulin concentration were 1.22 kg and 4.5 microU/ml, respectively. The multivariate adjusted insulin level became higher with the increase in weight fluctuation. Subanalysis stratified by current body mass index (BMI) showed that the multivariate adjusted insulin level in individuals in the top quartile of fluctuation was 4.3 microU/ml, against 3.9 microU/ml in those in the bottom quartile (P=0.018, analysis of covariance (ANCOVA)) in the normal weight subgroup with current BMI below 25 kg/m(2). In the overweight subgroup with BMI 25 kg/m(2) or above, the level was 6.9 microU/ml in individuals in the top quartile and 6.2 microU/ml in those in the bottom quartile (P=0.054, ANCOVA). CONCLUSION: The results suggest that weight fluctuation increases the risk of developing hyperinsulinemia. Prospective observations together with measurement of changes in adiposity are needed for confirmation.

  327. A prospective study of stomach cancer death in relation to green tea consumption in Japan. Reviewed

    Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T; Japan Collaborative Cohort Study Group.

    Br J Cancer   Vol. 87 ( 3 ) page: 309-13   2002.7

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  328. Role of the anterolateral thigh flap in head and neck reconstruction: advantages of moderate skin and subcutaneous thickness. Reviewed

    Nakayama B, Hyodo I, Hasegawa Y, Fujimoto Y, Matsuura H, Yatsuya H, Torii S.

    J Reconstr Microsurg   Vol. 18 ( 3 ) page: 141-6   2002.4

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  329. Short- and long-term reliability of information on previous illness and family history as compared with that on smoking and drinking habits in questionnaire surveys. Reviewed

    Zhu S, Toyoshima H, Kondo T, Tamakoshi K, Yatsuya H, Hori Y, Tsubono Y, Nishino Y, Tsuji I, Hisamichi S.

    J Epidemiol   Vol. 12 ( 2 ) page: 120-5   2002.3

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  330. Family history and the risk of stomach cancer death in Japan: differences by age and gender. Reviewed

    Yatsuya H, Toyoshima H, Mizoue T, Kondo T, Tamakoshi K, Hori Y, Tokui N, Hoshiyama Y, Kikuchi S, Sakata K, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T.

    International Journal of Cancer   Vol. 97 ( 5 ) page: 688-694   2002

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    Familial aggregation of stomach cancer has long been observed. The effect on disease risk of family history and its magnitude according to the type of affected relatives, however, is not well known. We conducted a prospective analysis using the JACC study (Japan Collaborative Cohort Study For Evaluation of Cancer Risk, sponsored by Monbusho) data. During the follow-up period, 662 stomach cancer deaths were documented. A positive history of stomach cancer in one or more first-degree relatives was associated with a significantly increased risk of death from the disease in both men (RR 1.60; 95% CI 1.11-2.31) and women (RR 2.47; 95% CI 1.50-4.06). In the subanalysis stratified by age, the association between positive family history and stomach cancer was stronger in the age group from 40-59 (RR 2.62; 95% CI 1.34-5.11 for men and RR 5.88; 95% CI 2.70-12.82 for women) than in the age group from 60-79 (RR 1.31; 95% CI 0.84-2.05 for men and RR 1.44; 95% CI 0.72-2.88 for women). In the age group from 40-59, men with father's history and women with mother's and sister's history of the disease had a significantly increased risk (RR 3.14; 95% CI 1.51-6.55, RR 10.46; 95% CI 4.54-24.12, RR 13.39; 95% CI 3.89-46.12, respectively). When 2 or more family members were affected, the increment in the risk was prominent especially in women (RR 9.45; 95% CI 4.46-20.05). These results suggest the existence of a certain subtype of stomach cancer that is inherited more often by women from one generation to the next in gender-influenced fashion. Any preventive strategy should take into account the degree of individual susceptibility.

  331. Trends in the mortality (1950-1997) and incidence (1975-1993) of malignant ovarian neoplasm among Japanese women: analyses by age, time, and birth cohort. Reviewed

    Tamakoshi K, Kondo T, Yatsuya H, Hori Y, Kikkawa F, Toyoshima H.

    Gynecol Oncol   Vol. 83 ( 1 ) page: 64-71   2001.10

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  332. 若年者の死亡について Invited

    玉腰浩司、八谷寛、堀容子、近藤高明、豊嶋英明.

    現代医学   Vol. 49   page: 169-173   2001

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  333. 産業保健における循環器疾患の一次予防対策 Invited

    豊嶋英明、八谷寛、近藤高明、玉腰浩司.

    産業医学レビュー   Vol. 13   page: 155-182   2001

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  334. A case of eosinophilic peritonitis in which ascites interleukin 5 presented at a high level.Hepatogastroenterology. Reviewed

    Yoshikane H, Yatsuya H, Sakakibara A, Hidano H, Arisawa T, Goto H.

    Hepatogastroenterology   Vol. 47 ( 36 ) page: 1588-9   2000

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  335. 成人における循環器疾患:進展とその予防. その1: 心疾患 Invited

    豊嶋英明、八谷寛.

    循環器専門医   Vol. 8   page: 55-62   2000

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  336. 職域大規模集団における健診成績のデータベース化とバイオマテリアル長期保存における生活習慣病の予防対策 高脂血症者における食習慣の変容に関する横断的解析結果 Invited

    八谷寛, 近藤高明, 堀容子, 玉腰浩司, 朱善寛, 川村孝, 吉田勉, 外山淳治, 岡本登, 島正吾, 豊嶋英明.

    協栄生命健康事業団研究助成論文集   Vol. 15   page: 65-73   1999

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  337. 日本の疾病負担と障害調整生存年(DALY) Reviewed

    福田吉治, 長谷川敏彦, 八谷寛, 田端航也.

    厚生の指標   Vol. 46   page: 28-33   1999

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  338. 発展途上国における下痢症の現状とその対策についての考察" Reviewed

    八谷寛, 豊嶋英明, 宮尾克, 肥田野等.

    社会医学研究   Vol. 17   page: 47-51   1999

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Books 12

  1. Obesity Epidemiology

    ( Role: Joint author)

    2010.10 

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  2. アディポネクチンとその受容体-抗生活習慣病ホルモンの全貌-門脇孝編(心肥大とアディポネクチン)

    三橋弘嗣、八谷寛、室原豊明、豊嶋英明、玉腰浩司( Role: Joint author)

    フジメディカル出版  2008.5 

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    Language:Japanese

  3. 動脈硬化・老年病予防健診マニュアル(胸部X線(心胸郭比))

    八谷寛、豊嶋英明. 小澤秀樹編( Role: Joint author)

    メジカルビュー社  2001 

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    Language:Japanese

  4. 循環器病予防ハンドブック(胸写・心電図)

    豊嶋英明、八谷寛、堀容子. 日本循環器管理研究協議会編.( Role: Joint author)

    保健同人社  2003 

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  5. 循環器疾患の予防・管理・治療マニュアル(胸写・心電図)

    豊嶋英明、八谷寛、堀容子.日本循環器管理研究協議会編.( Role: Joint author)

    保健同人社  2003 

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    Language:Japanese

  6. がん予防の最前線(胃がん)

    八谷寛, 星山佳治, 菊地正悟, 藤野善久, 吉村健清. 田島和雄監修( Role: Joint author)

    昭和堂  2005 

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    Language:Japanese

  7. テキスト健康科学改訂第3版

    編集 柴田英治/松原達昭/八谷寛( Role: Joint author)

    南江堂  2024.9  ( ISBN:978-4-524-23448-6

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    Language:Japanese Book type:Textbook, survey, introduction

  8. テキスト健康科学 = Textbook of health science

    柴田 英治, 松原 達昭, 八谷 寛, 佐藤 祐造( Role: Joint editor)

    南江堂  2024  ( ISBN:9784524234486

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    Language:Japanese Book type:Textbook, survey, introduction

    CiNii Books

  9. JACC Study −これまでの成果とあゆみ− Reviewed

    松永眞章、王超辰、八谷寛( Role: Joint author ,  脳血管疾患)

    予防医学広報事業団(⻘⽊平⼋郎・國雄記念)  2021.3  ( ISBN:978-4-9911825-0-1

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  10. テキスト健康科学

    八谷寛, 太田充彦(担当:分担執筆, 範囲:第4章 社会と健康)( Role: Joint author)

    南江堂  2017.2 

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    Language:Japanese Book type:Textbook, survey, introduction

  11. Textbook of Health Science

    Hiroshi Yatsuya, Atsuhiko Ota( Role: Contributor)

    2017.2 

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  12. 循環器病健康診査の手技と判定基準:肥満(循環器病予防ハンドブック 第7版)

    八谷寛、藤吉朗( Role: Joint author)

    保健同人社  2014.7 

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MISC 61

  1. 20歳代の体重増加はフレイル発症関連要因である-愛知職域コホート研究-

    洪英在, 大塚礼, 吉田裕子, SONG Zean, TAHMINA Akter, HAMRAH Hassan, GABRIEL Nuamar, 福田知里, 田島里菜, LIN Jingyi, SHI Zhiling, BARUCK Endale, 日比野瑞歩, 小林芽生, 松永眞章, 太田充彦, 中野嘉久, LI Yuanying, 玉腰浩司, 八谷寛

    日本疫学会学術総会講演集(Web)   Vol. 34th   2024

  2. 正期産SGA児における母体妊娠中期総コレステロール高値と非キャッチアップとの関連

    金子 佳世, 伊藤 由起, 榎原 毅, 加藤 沙耶香, 松木 太郎, 玉田 葉月, 佐藤 博貴, 齋藤 伸治, 杉浦 真弓, 八谷 寛, 上島 通浩

    Journal of Epidemiology   Vol. 33 ( Suppl.1 ) page: 124 - 124   2023.2

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    Language:Japanese   Publisher:(一社)日本疫学会  

    researchmap

  3. 20歳から中年期までの体重変化は,中年期から老年期までの体重変化から独立したフレイル発症関連要因である

    洪英在, 吉田裕子, MAMUN Razib, SONG Zean, HE Yupeng, 李媛英, 松永眞章, 中野嘉久, 江啓発, 平川仁尚, 大塚礼, 太田充彦, 玉腰浩司, 八谷寛

    日本疫学会学術総会講演集(Web)   Vol. 33rd   2023

  4. Increasing Role of Overweight/Obesity as the Determinant of Hypertension and the Consequent Cardiovascular Diseases in Japan Invited International journal

    Yatsuya Hiroshi

    Journal of Atherosclerosis and Thrombosis   Vol. advpub ( 0 )   2022.7

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    DOI: 10.5551/jat.ED212

    PubMed

  5. 特定健診およびレセプトデータを用いた愛知県岩倉市における心血管疾患発症リスクおよび人口寄与危険割合に関するコホート研究

    HE Yupeng, HE Yupeng, 江啓発, 藤社紗梨, 水野晴子, 平川仁尚, 八谷寛

    東海公衆衛生雑誌   Vol. 10 ( 1 )   2022

  6. Health of university students under job and financial insecurity during COVID-19 pandemic Invited International journal

    Yatsuya Hiroshi, Ishitake Tatsuya

    Journal of Occupational Health   Vol. 63 ( 1 ) page: e12223   2021.1

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    DOI: 10.1002/1348-9585.12223

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  7. エチオピア北部の公務員における高血圧前症と高血圧症の決定因子(Determinants of prehypertension and hypertension among public employees in northern Ethiopia)

    Saif-Ur-Rahman KM, Chiang Chifa, He Yupeng, Gebremariam Lemlem Weldegerima, Yatsuya Hiroshi, Aoyama Atsuko

    国際保健医療   Vol. 35 ( 3 ) page: 183 - 183   2020.9

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  8. Risk Factors of Infectious Complications After Endobronchial Ultrasound-Guided Transbronchial Biopsy. Reviewed International journal

    Tomohide Souma, Tomoyuki Minezawa, Hiroshi Yatsuya, Takuya Okamura, Kumiko Yamatsuta, Sayako Morikawa, Tomoya Horiguchi, Shingo Maeda, Yasuhiro Goto, Masamichi Hayashi, Sumito Isogai, Naoki Yamamoto, Masashi Kondo, Kazuyoshi Imaizumi

    Chest   Vol. 158 ( 2 ) page: 797 - 807   2020.8

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    BACKGROUND: Infectious complications after endobronchial ultrasound-guided transbronchial biopsy with a guide sheath (EBUS-GS-TBB) are serious in that they may delay or change scheduled subsequent therapy. The aim of this study was to identify risk factors for infection after EBUS-GS-TBB. RESEARCH QUESTION: What are the risk factors for infection after EBUS-GS-TBB? STUDY DESIGN AND METHODS: We retrospectively reviewed the medical records of 1,045 consecutive patients who had undergone EBUS-GS-TBB for peripheral lung lesions between January 2013 and December 2017 at Fujita Health University Hospital. We evaluated the following risk factors for infectious complications after EBUS-GS-TBB: relevant patient characteristics (age and comorbidities), lesion size, CT scan features of target lesion (intratumoral low-density areas [LDAs] and cavitation), stenosis of responsible bronchus observed by bronchoscopy, and laboratory data before EBUS-GS-TBB (WBC count and C-reactive protein concentration). RESULTS: Forty-seven of the study patients developed infectious complications (24 with pneumonia, 14 with intratumoral infection, three with lung abscess, three with pleuritis, and three with empyema), among whom the complication caused a delay in cancer treatment in 13 patients, cancellation of cancer treatment in seven patients, and death in three patients. Multivariate analysis showed that cavitation (P = .007), intratumoral LDAs (P < .001), and stenosis of responsible bronchus observed by bronchoscopy (P < .001) were significantly associated with infectious complications after EBUS-GS-TBB. Prophylactic antibiotics had been administered to 13 patients in the infection group. Propensity matched analysis could not show significant benefit of prophylactic antibiotics in preventing post-EBUS-GS-TBB infections. INTERPRETATION: Cavitation, LDAs for CT scan features of target lesions, and stenosis of responsible bronchus observed by bronchoscopy are risk factors of post-EBUS-GS-TBB infection. In the cohort, prophylactic antibiotics failed to prevent infectious complications.

    DOI: 10.1016/j.chest.2020.02.025

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  9. 安全衛生担当労働者における加熱式タバコの利用状況

    加藤 善士, 太田 充彦, 八谷 寛

    厚生の指標   Vol. 67 ( 6 ) page: 23 - 28   2020.6

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    目的 職域では受動喫煙対策とともに喫煙労働者への禁煙指導が課題となっている。日本の職域における加熱式タバコの使用実態を報告した論文は少ない。本研究の目的は,職域における加熱式タバコの使用実態を把握し,喫煙対策の実施につながる知見を得ることである。方法 某労働災害防止団体の地方センターにおいて2019年4月〜6月末の3ヵ月間に開催した安全衛生教育受講者(819人)を対象にした自記式質問紙調査を実施した。喫煙率,加熱式タバコ利用状況,年齢,性別,役職,企業規模,喫煙習慣との関連を調べた。回答者741人のうち,男性回答者で分析に必要な項目に欠損がなかった653人を解析した。結果 喫煙率は37.8%(247人)であった。現喫煙者割合は40〜49歳で高く(40.1%),過去喫煙者割合は50歳以上で高く(37.8%),非喫煙者割合は40歳未満で高かった(49.1%)(p<0.001)。役職,企業規模と現喫煙,過去喫煙,非喫煙の割合に有意な関連は認めなかった。現喫煙者247人の内,加熱式タバコのみを利用する者が67人(現喫煙者の27.1%),加熱式タバコと通常のタバコとの併用者が55人(現喫煙者の22.3%)であった。加熱式タバコの利用状況(加熱式のみ,併用,通常のタバコのみ)と年齢,役職,企業規模との間に統計学的に有意な関連は認めなかった。加熱式タバコの利用理由は「においが少ない」(67.2%),「煙が少ない」(47.5%),「火の心配が少ない」(43.4%),「自分の健康被害が少ないと思う」(35.2%),「周囲の健康被害が少ないと思う」(34.4%)であった。結論 男性労働者の喫煙率には年齢による差はあったが,企業規模や役職による差はなかった。男性労働者の加熱式タバコの利用は20%程度で,全喫煙者の約半分であった。本研究では,健康被害よりもにおいや火に関連した危険を理由として加熱式タバコを利用する者が多かった。事業場においては,通常のタバコへの喫煙対策と併せて加熱式タバコへの対策も行うことが望まれる。(著者抄録)

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  10. 中年期の空腹時血糖と高齢期の認知機能との関連:愛知職域コホート研究

    霜田真子, 八谷寛, 加藤綾子, 金子佳世, 中川威, 河野直子, 大塚礼, 太田充彦, 内藤久雄, 李媛英, 市野直浩, 山田宏哉, 江啓発, 平川仁尚, 玉腰浩司, 青山温子, 青山温子

    日本疫学会学術総会講演集(Web)   Vol. 30th   2020

  11. 生涯にわたる循環器疾患の個人リスクおよび集団のリスク評価ツールの開発を目的とした大規模コホート統合研究 統合研究リスクエンジン2(個人の10年リスク)個人の10年以内の循環器疾患の予測リスクの開発

    八谷寛, 李媛英, 田中佐智子, 村上義孝, 三浦克之, 辻一郎, 宮本恵宏, 坂田清美, 磯博康, 岡山明, 岡村智教

    生涯にわたる循環器疾患の個人リスクおよび集団のリスク評価ツールの開発を目的とした大規模コホート統合研究 令和元年度 総括・分担研究報告書(Web)     2020

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  12. 降圧薬ヒドララジンは高脂肪食摂取した高血圧ラットの肝線維化を抑制する

    内藤久雄, 袁媛, 北森一哉, 橋本沙幸, 浅野友美, 八谷寛, 那須民江

    日本衛生学雑誌(Web)   Vol. 75 ( Supplement )   2020

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  13. 肥満に関連する疾病の増加と対策

    八谷 寛

    日本医史学雑誌   Vol. 65 ( 2 ) page: 172 - 172   2019.6

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  14. 日常的なライフスタイルを如何に論文化するか? 複合的な健康習慣の指標と循環器病予防

    八谷 寛, 玉腰 浩司

    日本循環器病予防学会誌   Vol. 54 ( 2 ) page: 106 - 106   2019.4

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  15. 日本のがん患者の復職率 システマティックレビュー

    太田 充彦, 藤澤 明子, 河田 健司, 八谷 寛

    日本衛生学雑誌   Vol. 74 ( Suppl. ) page: S128 - S128   2019.2

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  16. 高血圧ラットは肝臓Cyp7a1 promoterメチル化頻度が高く、降圧剤投与で一部低下する

    内藤 久雄, 三宅 邦夫, 橋本 沙幸, 浅野 友美, 北森 一哉, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 74 ( Suppl. ) page: S177 - S177   2019.2

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  17. 高血圧ラットは肝臓Cyp7a1 promoterメチル化頻度が高く、降圧剤投与で一部低下する

    内藤 久雄, 三宅 邦夫, 橋本 沙幸, 浅野 友美, 北森 一哉, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 74 ( Suppl. ) page: S177 - S177   2019.2

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  18. 新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 食品摂取の多様性と尿中Na,K排泄量,血圧との関連:NIPPON DATA2010

    大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 門田文, 由田克士, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    新旧(1980-2020年)のライフスタイルからみた国民代表集団大規模コホート研究:NIPPON DATA80/90/2010/2020 平成30年度 総括・分担研究報告書(Web)     2019

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  19. 高血圧ラットは肝臓Cyp7a1promoterメチル化頻度が高く,降圧剤投与で一部低下する

    内藤久雄, 三宅邦夫, 橋本沙幸, 浅野友美, 北森一哉, 八谷寛, 那須民江

    日本衛生学雑誌(Web)   Vol. 74 ( Supplement )   2019

  20. γGTPとALT追加による10年間の2型糖尿病発症リスク予測能の改善 愛知職域コホート International journal

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 豊嶋 英明, 青山 温子

    日本公衆衛生学会総会抄録集   Vol. 77回   page: 204 - 204   2018.10

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  21. 食品摂取の多様性と尿中Na,K排泄量、血圧との関連 NIPPON DATA2010

    大塚 礼, 八谷 寛, 西 信雄, 奥田 奈賀子, 門田 文, 由田 克士, 大久保 孝義, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之

    日本公衆衛生学会総会抄録集   Vol. 77回   page: 322 - 322   2018.10

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  22. 健診と健康(地域健診、特定健診、職場健診は日本人の健康に寄与しているか?) 職域における若年期からの肥満対策と循環器病予防

    八谷 寛, 李 媛英, 平川 仁尚, 太田 充彦, 上村 真由, 江 啓発, 金子 佳世, 豊嶋 英明, 玉腰 浩司, 青山 温子

    日本循環器病予防学会誌   Vol. 53 ( 2 ) page: 166 - 166   2018.5

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  23. 成人男性におけるGGTとALTの組み合わせと2型糖尿病発症の関連 愛知職域コホート研究

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 青山 温子

    日本循環器病予防学会誌   Vol. 53 ( 2 ) page: 182 - 182   2018.5

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  24. 健診と健康(地域健診、特定健診、職場健診は日本人の健康に寄与しているか?) 職域における若年期からの肥満対策と循環器病予防

    八谷 寛, 李 媛英, 平川 仁尚, 太田 充彦, 上村 真由, 江 啓発, 金子 佳世, 豊嶋 英明, 玉腰 浩司, 青山 温子

    日本循環器病予防学会誌   Vol. 53 ( 2 ) page: 166 - 166   2018.5

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  25. 成人男性におけるGGTとALTの組み合わせと2型糖尿病発症の関連 愛知職域コホート研究

    金子 佳世, 八谷 寛, 李 媛英, 上村 真由, 江 啓発, 平川 仁尚, 太田 充彦, 玉腰 浩司, 青山 温子

    日本循環器病予防学会誌   Vol. 53 ( 2 ) page: 182 - 182   2018.5

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  26. IoT(Internet of Things)システムの糖尿病療養指導への応用

    小林 朋子, 後藤 資実, 尾上 剛史, 村本 あき子, 加藤 綾子, 栄口 由香里, 野村 恵里, 武藤 繁貴, 八谷 寛, 津下 一代, 有馬 寛

    糖尿病   Vol. 61 ( Suppl.1 ) page: S - 440   2018.4

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  27. DPCデータを用いた脳卒中・急性心筋梗塞発症把握の可能性の検討

    柿崎 真沙子, 澤田 典絵, 山岸 良匡, 八谷 寛, 斉藤 功, 小久保 喜弘, 磯 博康, 津金 昌一郎, 康永 秀生

    日本公衆衛生雑誌   Vol. 65 ( 4 ) page: 179 - 186   2018.4

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    目的 DPCデータを大規模なコホート研究の発症登録に利用することが可能であるかを検討するため、独自に収集した脳卒中および急性心筋梗塞発症登録数と、DPCデータを活用して得られた疾病登録数との比較を行い、脳卒中と急性心筋梗塞の各診断名において実施された治療・処置や検査から、標的疾患罹患の把握に有用な項目があるか検討した。方法 研究対象病院のDPCデータから、4種類(主傷病名、入院の契機となった病名、医療資源を最も投入した病名、医療資源を二番目に投入した病名)のいずれかに、急性心筋梗塞、脳内出血、脳梗塞が含まれる症例を抽出し、疾患ごとに実施された検査や治療の情報を抽出・集計し当該研究対象病院にてJPHC研究の一部として独自に収集した発症登録により得られた登録数を比較した。結果 DPLデータで抽出された症例数は独自に実施した発症登録数より多かったが、その差はとくに脳梗塞において顕著であった。JPHC登録数/DPC症例数の比は心筋梗塞1.13、脳内出血0.88、脳梗塞0.67であった。結論 急性心筋梗塞および脳内出血の疾病登録にはDPCデータを利用して、対象者数を概ね把握できる可能性が示された。脳梗塞についてはDPC登録病名とDPC治療・検査・診断項目を補助的に活用することで、疾病登録対象者数の同定精度を高め得る可能性がある。しかしながら、DPCデータを大規模なコホート研究の発症登録に利用するためには、地域全体での発症数がDPC導入病院の発症数でカバーできるのか、さらなる検討が必要である。(著者抄録)

    DOI: 10.11236/jph.65.4_179

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J01074&link_issn=&doc_id=20180511440004&doc_link_id=130006731380&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130006731380&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

  28. トリクロロエチレンによる過敏症症候群における曝露濃度と感受性因子の交互作用 International coauthorship

    那須 民江, 王 海蘭, 伊藤 由起, 内藤 久雄, 柳場 由絵, 八谷 寛, 上島 通浩

    日本衛生学雑誌   Vol. 73 ( Suppl. ) page: S276 - S276   2018.3

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  29. 某労働基準監督署管内2事業場(製造業)における「治療と職業生活の両立支援のためのガイドライン」の周知状況について

    加藤 善士, 太田 充彦, 八谷 寛

    産業衛生学雑誌   Vol. 60 ( 2 ) page: 55 - 55   2018.3

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  30. 高血圧及び高脂肪食摂取はラット肝臓Cyp7a1プロモーターのメチル化頻度を増加させる

    内藤 久雄, 三宅 邦夫, 袁 媛, 橋本 沙幸, 北森 一哉, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 73 ( Suppl. ) page: S230 - S230   2018.3

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  31. 警察官採用に関わる色彩識別能力評価基準について

    高柳 泰世, 八谷 寛, 宮尾 克, 太田 充彦

    産業衛生学雑誌   Vol. 60 ( 2 ) page: 55 - 55   2018.3

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  32. 警察官採用に関わる色彩識別能力評価基準について

    高柳 泰世, 八谷 寛, 宮尾 克, 太田 充彦

    産業衛生学雑誌   Vol. 60 ( 2 ) page: 55 - 55   2018.3

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  33. トリクロロエチレンによる過敏症症候群における曝露濃度と感受性因子の交互作用

    那須 民江, 王 海蘭, 伊藤 由起, 内藤 久雄, 柳場 由絵, 八谷 寛, 上島 通浩

    日本衛生学雑誌   Vol. 73 ( Suppl. ) page: S276 - S276   2018.3

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  34. 某労働基準監督署管内2事業場(製造業)における「治療と職業生活の両立支援のためのガイドライン」の周知状況について

    加藤 善士, 太田 充彦, 八谷 寛

    産業衛生学雑誌   Vol. 60 ( 2 ) page: 55 - 55   2018.3

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  35. 高血圧及び高脂肪食摂取はラット肝臓Cyp7a1プロモーターのメチル化頻度を増加させる

    内藤 久雄, 三宅 邦夫, 袁 媛, 橋本 沙幸, 北森 一哉, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 73 ( Suppl. ) page: S230 - S230   2018.3

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  36. 自宅から鉄道駅,バス停,職場までの距離と歩行時間との関連―愛知職域コホート

    八谷寛, 八谷寛, 李媛英, 埴淵知哉, 平川仁尚, 太田充彦, 加藤善士, 藤澤明子, 松永眞章, 大塚礼, 村田千代栄, 江啓発, 玉腰浩司, 豊嶋英明, 青山温子

    日本疫学会学術総会講演集(Web)   Vol. 28th   page: 129 (WEB ONLY)   2018.2

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  37. 食品摂取の多様性と心血管危険因子に関する検討:NIPPON DATA2010

    大塚礼, 大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 門田文, 由田克士, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    日本疫学会学術総会講演集(Web)   Vol. 28th   page: 116 (WEB ONLY)   2018.2

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  38. 料理データベース食事調査Webシステムのコホートでの活用に関するパイロット研究~第2報 摂取量の推定結果~

    加藤祐子, 石原淳子, 八谷寛, 八谷寛, 田中純太, 藤田みほ, 西本侑加, 丸谷幸子, 青山温子, 平川仁尚, 江啓発, 澤田典絵, 井上真奈美, 高地リベカ

    日本疫学会学術総会講演集(Web)   Vol. 28th   page: 104 (WEB ONLY)   2018.2

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  39. 日本人一般住民における教育歴・経済状態と炎症マーカーの関連:NIPPON DATA2010

    村上慶子, 大久保孝義, 渡邉至, 二宮利治, 大西浩文, 八谷寛, 高嶋直敬, 宮川尚子, 門田文, 奥田奈賀子, 西信雄, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    日本疫学会学術総会講演集(Web)   Vol. 28th   page: 114 (WEB ONLY)   2018.2

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  40. 料理ベース食事調査Webシステムのコホートでの活用に関するパイロット研究~第1報 実施方法と回答状況~

    藤田みほ, 石原淳子, 八谷寛, 八谷寛, 田中純太, 西本侑加, 丸谷幸子, 平川仁尚, 江啓発, 加藤祐子, 澤田典絵, 井上真奈美, 青山温子, 高地リベカ

    日本疫学会学術総会講演集(Web)   Vol. 28th   page: 103 (WEB ONLY)   2018.2

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  41. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 食品摂取の多様性と心血管危険因子に関する検討:NIPPON DATA2010

    大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 門田文, 由田克士, 大久保孝義, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成29年度 総括・分担研究報告書(Web)     page: 91‐94 (WEB ONLY)   2018

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  42. Pilot peer health education for noncommunicable disease prevention in Bangladesh, Ethiopia, and Palau

    Lemlem W Gebremariam, Yoshihisa Hirakawa, Shahrin E Rayna, Fahmida A Khan, Chifa Chiang, Yupeng He, Everlynn J Temengil, Sherilynn Madraisau, Md Khalequzzaman, Sohel R Choudhury, Hiroshi Yatsuya, Atsuko Aoyama

    Journal of global health report   Vol. 2   page: e2018039   2018

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  43. 高血圧因子及び高脂肪食摂取がラット肝臓Cyp7a1プロモーター領域のDNAメチル化頻度を増加させる

    内藤久雄, 三宅邦夫, 袁媛, 橋本沙幸, 北森一哉, 八谷寛, 那須民江

    高血圧関連疾患モデル学会学術総会抄録集   Vol. 54th   2018

  44. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 日本人一般住民における教育歴・経済状態と炎症マーカーの関連:NIPPON DATA2010

    村上慶子, 大久保孝義, 渡邉至, 二宮利治, 大西浩文, 八谷寛, 高嶋直敬, 宮川尚子, 門田文, 奥田奈賀子, 西信雄, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成29年度 総括・分担研究報告書(Web)     2018

  45. わが国の循環器疾患の危険因子「冠動脈疾患」

    松永 眞章, 八谷 寛

    日本循環器病予防学会誌   Vol. 52 ( 3 ) page: 244 - 254   2017.12

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    国際的には低い冠動脈疾患発症率を誇るわが国ではあるが、肥満や不活発な生活習慣の蔓延による耐機能異常、脂質異常の割合の増加により、男性、特に都市部男性における発症率の増加が示唆されている。わが国における冠動脈疾患の危険因子(高血圧、脂質異常症、糖尿病、喫煙、肥満、メタボリックシンドローム、慢性腎臓病、飲酒)について、定義、冠動脈疾患発症、死亡との関連の特徴などについて個々に概説した。

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  46. 家庭での受動喫煙とその後のCOPDによる死亡との関連 JACC Study

    鵜川 重和, 玉腰 暁子, 八谷 寛, 山岸 良匡, 安藤 昌彦, 磯 博康

    北海道公衆衛生学雑誌   Vol. 31 ( 1特別付録 ) page: 90 - 90   2017.11

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  47. 家庭での受動喫煙とその後のCOPDによる死亡との関連 JACC Study

    鵜川 重和, 玉腰 暁子, 八谷 寛, 山岸 良匡, 安藤 昌彦, 磯 博康

    北海道公衆衛生学雑誌   Vol. 31 ( 1特別付録 ) page: 90 - 90   2017.11

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  48. Internet of Things(IoT)を活用した生活習慣改善支援の取り組み

    野村 恵里, 栄口 由香里, 加藤 綾子, 村本 あき子, 武藤 繁貴, 八谷 寛, 津下 一代

    日本公衆衛生学会総会抄録集   Vol. 76回   page: 454 - 454   2017.10

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  49. パラオにおける食行動(果物・野菜摂取及び外食の頻度)と肥満との関連

    大内 詩野, 崔 仁哲, 本庄 かおり, 江 啓発, 八谷 寛, 青山 温子, 磯 博康

    日本公衆衛生学会総会抄録集   Vol. 76回   page: 411 - 411   2017.10

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  50. パラオ共和国の若年者における飲酒と薬物使用の現状

    佐田 みずき, 崔 仁哲, 江 啓発, 八谷 寛, 本庄 かおり, 三田 貴, 磯 博康, 青山 温子

    日本アルコール・薬物医学会雑誌   Vol. 52 ( 4 ) page: 211 - 211   2017.8

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  51. 某労働基準監督署管内事業場における治療と職業生活の両立支援のための職場環境・労務管理制度

    加藤 善士, 太田 充彦, 八谷 寛

    東海公衆衛生雑誌   Vol. 5 ( 1 ) page: 102 - 110   2017.7

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    目的 「事業場における治療と職業生活の両立支援のためのガイドライン(両立支援ガイドライン)」の認知、両立支援のための職場環境・労務管理体制の整備の実態、それらと事業場規模、事業場内産業保健スタッフ、過去の私傷病退職者・がん罹患者の有無との関連の探索。方法 某労働基準監督署管内の1,002事業場を対象に自記式質問紙調査を実施した。両立支援ガイドラインの認知割合、両立支援のための職場環境として啓発研修、相談・申出窓口、事業場内外の関係者間の情報交換の枠組みの有無、および、私傷病時に利用可能な労務管理制度として時差出勤、所定労働時間の短縮、時間単位の休暇、試し出勤、傷病・病気休暇の有無を調べ、事業場の規模による違いをコクラン・アーミテージ検定にて検定した。それらと事業場内産業保健スタッフ、および過去3年間に私傷病で退職した従業員・がんに罹患した従業員の有無との関連を調べ、Fisher正確確率検定で検定した。結果 266事業場から回答があり、回答率は27%であった。両立支援ガイドライン認知の割合は19%で、その割合は事業場規模が大きいほど高かった。啓発研修は7%、相談・申出窓口は38%、情報交換の枠組みは33%の事業場で行われており、事業場規模が大きいほどこの割合が高かった。従業員数50人未満の小規模事業場においては、事業場内産業保健スタッフのいる事業場で啓発研修(20%)、相談・申出窓口(52%)、情報交換の枠組み(48%)の実施割合が産業保健スタッフのいない事業場よりも高かった。両立支援のための各種労務管理制度の導入割合は1〜3割で、時間単位の休暇および傷病休暇・病気休暇は、事業場規模が大きいほど導入割合が高かった。過去3年間に私傷病で退職した従業員・がんに罹患した従業員の有無と両立支援のための職場環境・労務管理制度の有意な関連はなかった。ガイドラインを認知していた事業場では、従業員数50〜299人の中規模事業場では所定労働時間の短縮がより多く実施されていた。結論 両立支援ガイドライン認知の割合は低く、さらなる周知が望ましい。両立支援のための職場環境・労務管理制度の導入割合は一部先行研究よりも高く、事業場規模、産業保健スタッフの有無による違いを認めた。(著者抄録)

    DOI: 10.24802/tpha.5.1_102

    CiNii Books

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J06245&link_issn=&doc_id=20170711480055&doc_link_id=%2Ffe4tokai%2F2017%2Fs00501%2F007%2F0102-0110%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffe4tokai%2F2017%2Fs00501%2F007%2F0102-0110%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  52. IoT(Internet of Things)システムを用いた療養指導強化による糖代謝改善についての検討 教育入院患者を対象とした前向き研究

    小林 朋子, 後藤 資実, 尾上 剛史, 村本 あき子, 加藤 綾子, 栄口 由香里, 野村 恵里, 武藤 繁貴, 八谷 寛, 津下 一代, 有馬 寛

    糖尿病   Vol. 60 ( Suppl.1 ) page: S - 376   2017.4

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  53. 宿泊型新保健指導プログラム(第2報) 1年後の効果検証

    松下 まどか, 矢部 大介, 小熊 祐子, 佐野 喜子, 樺山 舞, 八谷 寛, 荒川 雅志, 村本 あき子, 津下 一代

    糖尿病   Vol. 60 ( Suppl.1 ) page: S - 245   2017.4

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  54. 【産業ストレスのバイオロジー:生物学的指標の現在と展望】 職業性心理社会的要因と視床下部-下垂体-副腎皮質系ホルモンの関連

    太田 充彦, 八谷 寛

    産業ストレス研究   Vol. 24 ( 2 ) page: 205 - 211   2017.4

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  55. 解毒酵素の発現抑制が食餌性由来肝線維化進展に重要である

    内藤 久雄, 賈 小芳, 北森 一哉, 袁 媛, 八谷 寛, 那須 民江

    日本衛生学雑誌   Vol. 72 ( Suppl. ) page: S218 - S218   2017.3

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  56. A Point-based Prediction Model for Predicting 10-year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study

    Yuanying Li, Hiroshi Yatsuya, Yoshihisa Hirakawa, Atsuhiko Ota, Masaaki Matsunaga, Hilawe Esayas Haregot, Chifa Chiang, Yan Zhang, Koji Tamakoshi, Hideaki Toyoshima, Atsuko Aoyama

    CIRCULATION   Vol. 135   2017.3

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  57. 社会的要因と食品摂取の多様性に関する検討:NIPPON DATA2010

    大塚礼, 大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 尾島俊之, 中村美詠子, 由田克士, 藤吉朗, 門田文, 大久保孝義, 近藤慶子, 宮川尚子, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    日本疫学会学術総会講演集(Web)   Vol. 27th   page: 141 (WEB ONLY)   2017.1

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  58. GISにより評価した自宅近隣のwalkabilityと散歩・早歩き習慣との関連―愛知職域コホート

    李媛英, 八谷寛, 八谷寛, 埴淵知哉, 平川仁尚, 太田充彦, 加藤善士, 藤澤明子, 松永眞章, 大塚礼, 村田千代栄, 江啓発, 玉腰浩司, 豊嶋英明, 青山温子

    日本疫学会学術総会講演集(Web)   Vol. 27th   page: 109 (WEB ONLY)   2017.1

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  59. 地理的剥奪・ソーシャルキャピタルと主観的健康感の関連―愛知職域コホート

    村田千代栄, 八谷寛, 八谷寛, 埴淵知哉, 李媛英, 大塚礼, 豊嶋英明, 平川仁尚, 太田充彦, 加藤善士, 藤澤明子, 松永眞章, 江啓発, 玉腰浩司, 青山温子

    日本疫学会学術総会講演集(Web)   Vol. 27th   page: 116 (WEB ONLY)   2017.1

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  60. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 社会的要因と食品摂取の多様性に関する検討:NIPPON DATA2010

    大塚礼, 八谷寛, 西信雄, 奥田奈賀子, 尾島俊之, 中村美詠子, 由田克士, 藤吉朗, 門田文, 大久保孝義, 近藤慶子, 宮川尚子, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)     page: 80‐84 (WEB ONLY)   2017

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  61. 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 健康な日本人代表一般集団における非特異的心電図異常と血清ナトリウム利尿ペプチド(BNP)・高感度CRPの関連-NIPPON DATA2010-

    清原裕, 渡邉至, 大西浩文, 八谷寛, 野村恭子, 杉山大典, 高嶋直敬, 神田秀幸, 宮本恵宏, 中村保幸, 二宮利治

    社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010 平成28年度 総括・分担研究報告書(Web)     2017

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Presentations 95

  1. 第一次緊急事態宣言下における大学生の日常行動とメンタルヘルスとの関係

    橋本幸之助、江啓発、八谷寛、HE Yupeng、平野有希子、平川仁尚、太田充彦、若泉謙太、島津明人、田淵貴大

    第39回日本国際保健医療学会西日本地方会  2021.3.6 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Poster presentation  

  2. 職域における糖尿病の病態:発症予防・治療管理・予後 Invited

    八谷寛

    第55回糖尿病学の進歩  2021.3.5  日本糖尿病学会

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:札幌  

  3. Automated Web-based Assessment system using Recipe-Data for Japanese (AWARDJP) – a pilot study for the middle and old age population-base cohort studies in Japan International conference

    Ribeka Takachi, Junko Ishihara, Sachiko Maruya, Junta Tanaka, Hiroshi Yatsuya, Atsuko Aoyama, Yoshihisa Hirakawa, Chifa Chiang, Tsuneo Konta, Takamasa Kayama, Manami Inoue, Norie Sawada, Shoichiro Tsugane

    eICDAM (International Conference on Diet and Activity Methods) 2021  2021.2.8 

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    Event date: 2021.2

    Language:English   Presentation type:Poster presentation  

    Venue:Ede   Country:Netherlands  

  4. Comparison of artificial neural network and logistic regression for predicting common metabolic outcomes

    Yupeng HE, Chifa CHIANG, Yoshihisa HIRAKAWA, Hiroshi YATSUYA

    第31回日本疫学会学術総会  2021.1.27 

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    Event date: 2021.1

    Language:English   Presentation type:Oral presentation (general)  

  5. 職域男性就労者における現喫煙者の禁煙指導・意識と過去喫煙者の禁煙理由について(職域におけるアンケート調査から)

    加藤善士、太田充彦、八谷寛

    第66回東海公衆衛生学会  2020.7.11 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

  6. A Point-based Prediction Model for Predicting 10-year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study International conference

    Yuanying Li, Hiroshi Yatsuya, Yoshihisa Hirakawa, Atsuhiko Ota, Masaaki Matsunaga, Hilawe Esayas Haregot, Chifa Chiang, Yan Zhang, Koji Tamakoshi, Hideaki Toyoshima, Atsuko Aoyama

    CIRCULATION  2017.3.7  LIPPINCOTT WILLIAMS & WILKINS

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

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  7. 肥満度と心筋梗塞、脳卒中発症の関連---JALS研究シンポジウム 日本の心臓血管疾患の疫学研究:大規模コホート統合研究(JALS)

    八谷 寛

    第58回日本心臓病学会学術集会 

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    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  8. Conventional Risk Factors for Heart Failure Mortality: The JACC Study International conference

    50th Cardiovascular Disease Epidemiology and Prevention Annual Conference (American Heart Association) 

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    Event date: 2010.3

    Language:English   Presentation type:Poster presentation  

  9. Race and Sex-Specific Associations of Obesity Measures with Ischemic Stroke Incidencein the ARIC Study International conference

    50th Cardiovascular Disease Epidemiology and Prevention Annual Conference (American Heart Association) 

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    Event date: 2010.3

    Language:English   Presentation type:Poster presentation  

  10. Independent association of serum adiponectin and alanine amino transferase with the incidence of diabetes mellitus in middle-aged Japanese men: 5-year follow-up International conference

    Li Y, Yatsuya H, Toyoshima H, Iso H, Tamakoshi K.

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    Event date: 2010.1

    Language:English  

    Country:Japan  

  11. 職域集団から学ぶ肥満の成因と健康影響 産業保健課題としての肥満の成因・病態と予防

    豊嶋英明、八谷 寛、近藤良伸、玉腰浩司

    平成21年度日本産業衛生学会東海地方会学会シンポジウム 

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    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  12. Body mass index and mortality among Japanese older adults: Findings from the JACC Study International conference

    Obesity 2009―27th Annual Scientific Meeting of the Obesity Society 

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    Event date: 2009.10

    Language:English   Presentation type:Oral presentation (general)  

  13. 生活習慣とメタボリックシンドローム発症リスクに関する追跡研究

    李媛英、八谷寛、豊嶋英明、玉腰浩司

    第68回日本公衆衛生学会総会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  14. 勤労男性における「食事バランスガイド」を参考にした食生活の実現可能性と課題

    嶋田雅子、武見ゆかり、大久保公美、村上健太郎、大塚礼、八谷寛、佐々木敏

    第56回日本栄養改善学会学術総会 

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    Event date: 2009.9

    Language:Japanese  

    Country:Japan  

  15. 体格と身体活動の乳がんに対するリスク-JACC Studyの知見より.

    鈴木貞夫,小嶋雅代,徳留信寛,森満,坂内文男,藤野善久,若井建志,玉腰浩司,八谷寛,林櫻松,菊地正悟,玉腰暁子.

    第10回日本がん分子疫学研究会 第16回日本がん予防学会 第32回日本がん疫学研究会 

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    Event date: 2009.6

    Language:Japanese  

    Country:Japan  

  16. Body Mass Index and Risk of Stroke in Japanese Men and Women: A Meta-analysis of 16 Cohorts in Japan International conference

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    Event date: 2009.3

    Language:English   Presentation type:Poster presentation  

  17. 高齢者のBMIと総死亡リスク:JACCStudyから

    玉腰暁子, 林櫻松, 柳生聖子, 菊地正悟, 鈴木貞夫, 玉腰浩司, 近藤高明, 八谷寛

    第19回日本疫学会学術総会. 

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    Event date: 2009.1

    Language:Japanese  

    Country:Japan  

  18. Lifestyle and incidence of metabolic syndrome: a follow-up study International conference

    The Obesity Society's 2007 Annual Scientific Meeting 

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    Event date: 2007.10

    Language:English   Presentation type:Oral presentation (general)  

    Background
    Metabolic syndrome (MS) is a high risk state for the development of cardiovascular diseases and diabetes. In this study, adherence to healthy lifestyles were examined for their composite effect on the incidence of MS in Japan.
    Methods
    Men who did not have two or more MS components nor past medical history of cancer, cardiovascular diseases, diabetes, hypertension, and hyperlipidemia were followed for three years to the incidence of MS (n=1,688, mean age: 46.2 years old, mean body m

  19. Eating fast leads to obesity: Findings in Japanese non-diabetic men and women. International conference

    The North American Association of Study of Obesity 2005 Annual Scientific Meeting 

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    Event date: 2005.11

    Language:English   Presentation type:Poster presentation  

  20. Hypoadiponectinemia adds further inflamatory information to ordinary metabolic syndrome components. International conference

    European Society of Cardiology Congress (Stockholm, Sweden) 

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    Event date: 2005.10

    Language:English   Presentation type:Oral presentation (general)  

  21. Association between birth weight and white blood cell count in adulthood. International conference

    The XVII International scientific meeting of the international epidemiological association (Bangkok, Thailand) 

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    Event date: 2005.8

    Language:English   Presentation type:Poster presentation  

  22. Factors associated with insomnia among male civil servants in Japan. International conference

    The XVII International scientific meeting of the international epidemiological association (Bangkok, Thailand) 

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    Event date: 2005.8

    Language:English   Presentation type:Poster presentation  

  23. 心理的要因と乳がんリスクとの関連-大規模コホートによる検討-

    若井建志, 小嶋雅代, 八谷寛, 他10人(4番目).

    第15回日本疫学会( 大津) 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. 極めて健康な成人男性におけるadiponectinとC反応性蛋白の関連

    松下邦洋、八谷寛、玉腰浩司、他

    第40回日本循環器病予防学会(横浜) 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  25. 生活習慣病の家族歴と罹患集積状況との関連

    和田恵子、玉腰浩司、八谷寛、他.

    第40回日本循環器病予防学会(横浜) 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  26. 食べる速さと現在のBMI、20歳からのBMI変化量との関連

    大塚礼、玉腰浩司、八谷寛、他.

    第40回日本循環器病予防学会(横浜) 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  27. Simultaneous deterioration of several cardiovascular disease predictors in apparently healthy Japanese Men with metabolic syndrome.

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    Event date: 2005

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  28. 縦断的検討による「腹いっぱい食べる」習慣の推移と5年間のBMI変化量との関係.

    大塚礼、八谷寛、玉腰浩司、他5人(2番目).

    第15回日本疫学会(大津) 

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    Event date: 2005

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  29. 日本の事務職男性公務員における不眠と職業ストレスとの関連.

    村田千代栄、八谷寛、玉腰浩司、他4人(2番目).

    第15回日本疫学会(大津) 

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    Event date: 2005

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  30. 同一個人の追跡観察からえた経年的血圧測定値の多重レベル解析-階層構造データへの適用の利点-

    近藤高明, 渡邊ゆかり, 八谷寛, 他3人(4番目).

    第15回日本疫学会( 大津) 

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    Event date: 2005

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  31. Life Space and Mortality among the Functionally Independent Elderly. International conference

    132nd Annual Meeting of The American Public Health Association (Washington DC, USA) 

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    Event date: 2004.11

    Language:English   Presentation type:Oral presentation (general)  

  32. Perceived Mental Stress and Serum Leptin Concentration in Japanese Male Workers International conference

    The North American Association of Study of Obesity 2004 Annual Scientific Meeting (Las Vegas, USA) 

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    Event date: 2004.11

    Language:English   Presentation type:Poster presentation  

  33. Characteristics of Community Dwelling Homebound Elderly in Japan : Baseline Report. International conference

    132nd Annual Meeting of The American Public Health Association (Washington DC, USA) 

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    Event date: 2004.11

    Language:English   Presentation type:Oral presentation (general)  

  34. 7年間の追跡研究による地域在住高齢者の日常活動度と生命予後の関連について

    村田千代栄、近藤高明、八谷寛、他5人(6番目).

    愛知県公衆衛生研究会(大府) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  35. 脂質摂取と乳がん罹患リスクとの関連 日本における大規模コホート研究による検討.

    若井建志, 玉腰浩司, 八谷寛, 他8人(3番目).

    第63回日本癌学会( 福岡) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  36. 大豆製品摂取と乳がん罹患リスクとの関連.

    西尾和子、玉腰浩司、八谷寛、他7人(3番目).

    第63回日本癌学会(福岡) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  37. アディポネクチンは肥満度、インスリン抵抗性とは独立にMetabolic Syndromeに関連する

    八谷寛、玉腰浩司、大塚礼、近藤高明、豊嶋英明.

    第25回日本肥満学会(大阪) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  38. 各種肥満指標をmetabolic syndrome関連兆候のスクリーニングに用いた場合の有用性

    近藤高明、堀容子、八谷寛、玉腰浩司、豊嶋英明.

    第25回日本肥満学会(大阪) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  39. 職域男性における自覚的ストレスと血清レプチン濃度との関連

    大塚礼、八谷寛、玉腰浩司、他4人(2番目).

    第25回日本肥満学会(大阪) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  40. 人口寄与危険度割合を用いた職域集団での高血圧危険要因の評価 オッズ比との比較

    近藤高明、八谷寛、玉腰浩司、岡村愛.

    第77回産業衛生学会(名古屋) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  41. Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases.

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    Event date: 2004

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  42. 職域コホート研究における既往歴の妥当性(虚血性心疾患及び脳卒中)

    八谷寛、豊嶋英明、張恵明、他7人(1番目).

    第14回日本疫学会(山形) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  43. 長期の体重変動とMetabolic Syndromeとの関連

    張恵明、玉腰浩司、八谷寛、他8人(3番目).

    第14回日本疫学会(山形) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  44. 血清レプチン値と高血圧の関連

    和田恵子、八谷寛、間淵智子、他7人(2番目).

    第14回日本疫学会(山形) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  45. 自覚的ストレスと血清レプチン濃度との関連(男性における関連)

    大塚礼、八谷寛、玉腰浩司、他7人(2番目).

    第14回日本疫学会(山形) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  46. A nested case-control study of stomach cancer in relation to green tea consumption in Japan.

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    Event date: 2004

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  47. 前向き研究による血清Helicobacter pyloli、低pepsinogenと胃がんリスク.

    菊地正悟, 柳生聖子, 八谷寛, 他11人(5番目).

    第14回日本疫学会(山形) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  48. 職域集団における自己申告の身長、体重の妥当性

    和田恵子、玉腰浩司、八谷寛、他6人(8番目).

    第39回日本循環器病予防学会(旭川) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  49. 濃い味の好みと肥満との関連性に関する検討

    堀容子、大塚礼、八谷寛、他4人(4番目).

    第39回日本循環器病予防学会(旭川) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  50. 大塚礼、八谷寛、玉腰浩司、他4人(2番目). 職域コホートにおける血清レプチン濃度と生活習慣との関連

    第39回日本循環器病予防学会(旭川) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  51. 生殖歴と乳がん罹患リスクとの関連.

    玉腰浩司, 豊嶋英明, 八谷寛, 他7人(8番目).

    第63回日本癌学会( 福岡) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  52. Power to detect prior myocardial infarction by ECG findings at health examination. International conference

    The 31st International Congress on Electrocardiology (Kyoto, Japan) 

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    Event date: 2004

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  53. メタボリックシンドロームにおけるアディポネクチンの意義.

    八谷寛

    第1回名古屋循環器疫学研究会(名古屋) 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  54. 飲酒と女性乳がん罹患リスクの関連.

    林櫻松, 菊地正悟, 八谷寛, 他9人(5番目).

    第63回日本癌学会( 福岡) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  55. 喫煙と卵巣癌罹患リスクの関連.

    丹羽慶光, 西尾和子, 八谷寛, 他7人(5番目).

    第63回日本癌学会( 福岡) 

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    Event date: 2004

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  56. 健診時心電図による冠動脈閉塞の既往に対する判定精度について

    張恵明、八谷寛、玉腰浩司、近藤高明、豊嶋英明.

    第19回心電情報ワークショップ(小田原) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  57. 若年期からの体重変化、体重変動と血清レプチン濃度との関連

    八谷寛、玉腰浩司、吉田 勉、他3人(1番目).

    第24回日本肥満学会(千葉) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  58. 禁煙による食生活の変化と体重増加との関係

    八谷寛、太田尚寿、玉腰浩司、他8人(1番目).

    第38回日本循環器病予防学会(和歌山) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  59. 多変量解析を用いた高血圧と脳卒中のfamilial aggregationとcoaggregationの評価

    近藤高明、豊嶋英明、八谷寛、他4人(4番目).

    第38回日本循環器病予防学会(和歌山) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  60. 間淵智子、八谷寛、玉腰浩司、他6人(2番目). 愛知県職域コホートのベースラインデータ時におけるレプチンと白血球の関連

    第38回日本循環器病予防学会(和歌山) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  61. 日本人男性における体重変動と空腹時血清インスリン濃度との関連

    八谷寛、玉腰浩司、張 恵明、他8人(1番目).

    第13回日本疫学会(福岡) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  62. 体重変動と軽度C-reactive protein上昇との関連

    玉腰浩司、八谷寛、近藤高明、他8人(2番目).

    第13回日本疫学会(福岡) 

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    Event date: 2003

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  63. 扁平足における足裏の痛み・疲れ、および扁平足と肥満との関連性

    大塚礼、八谷寛、村田千代栄、他12人(2番目).

    第13回日本疫学会(福岡) 

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    Event date: 2003

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  64. 「濃い味付けの好み」と心血管リスクファクターとの関連性についての検討

    堀容子、豊嶋英明、近藤高明、玉腰浩司、八谷寛.

    第13回日本疫学会(福岡) 

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    Event date: 2003

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  65. 健診時心電図の判読における留意点の抽出.

    張恵明、八谷寛、玉腰浩司、他11人(2番目).

    第49回東海公衆衛生学会(浜松) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  66. 長野県阿南町での下肢からの高齢者健康づくり事業の評価-下肢機能と測定形態の変化からみた介入効果-

    近藤高明、堀容子、八谷寛、他7人(4番目).

    第14回日本老年医学会東海地方会(名古屋) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  67. Self rated health after medical care utilization. International conference

    131st Annual Meeting of The American Public Health Association (San Franscisco, USA) 

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    Event date: 2003

    Language:English   Presentation type:Oral presentation (general)  

  68. 甘粛省天水市奥地の衛生院と小学校の視察に基づいた中国辺境地の衛生と教育事情に関する一活動報告

    石川美由紀、近藤高明、八谷寛、他5人(4番目).

    第48回東海公衆衛生学会(津) 

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    Event date: 2002

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  69. インスリン濃度と危険因子集積の検討

    八谷寛、玉腰浩司、吉田 勉、他2人(1番目).

    第23回日本肥満学会(京都) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  70. 簡易食事調査法の再現性と妥当性

    八谷寛、大脇淳子、小出浩司、他5人(1番目).

    第12回日本疫学会(東京) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  71. 成人男性集団における危険要因の重積と血清レプチン値、インシュリン値との関連

    近藤高明、八谷寛、玉腰浩司、堀容子、豊嶋英明.

    第12回日本疫学会(東京) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  72. 炎症マーカーであるCRPとMetabolic Syndromeとの関連

    玉腰浩司、八谷寛、近藤高明、他6人(2番目).

    第12回日本疫学会(東京) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  73. 高齢者の社会関係は生命予後に影響を与えるか?

    村田千代栄、近藤高明、八谷寛、他5人(5番目).

    第61回日本公衆衛生学会(大宮) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  74. 地域における高齢者の健康に関する研究II. -高齢者の閉じこもりに関する追跡調査を中心に-

    石川美由紀、近藤高明、八谷寛、他7人(4番目).

    第48回東海公衆衛生学会(津) 

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    Event date: 2002

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  75. 高齢者の社会関係が生命予後に与える影響について

    村田千代栄、近藤高明、八谷寛、他5人(5番目).

    第48回東海公衆衛生学会(津) 

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    Event date: 2002

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  76. 高齢者における肥満と扁平足及び外反母趾との関連

    大塚礼、八谷寛、村田千代栄、他8人(2番目).

    第48回東海公衆衛生学会(津) 

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    Event date: 2002

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  77. 中国辺境地の衛生と教育事情I-甘粛省天水市奥地の衛生院と小学校の視察をもとに-

    石川美由紀、張恵明、八谷寛、豊嶋英明.

    第17回日本国際保健医療学会(神戸) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  78. 地域における高齢者の閉じこもりに関する研究

    石川美由紀、近藤高明、八谷寛、他4人(4番目).

    第61回日本公衆衛生学会(大宮) 

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    Event date: 2002

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  79. 職域における循環器疾患予防.

    八谷寛、豊嶋英明、近藤高明、堀容子、玉腰浩司.

    平成13年度日本産業衛生学会東海地方会(名古屋) 

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    Event date: 2001

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  80. 体重変動とインスリン濃度との関連

    八谷寛、玉腰浩司、近藤高明、他3人(1番目).

    第22回日本肥満学会(前橋) 

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    Event date: 2001

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  81. 20代からの体重変化と脳・心血管疾患リスクファクター集積との関連

    八谷寛、玉腰浩司、堀 容子、他7人(1番目).

    第11回日本疫学会(つくば) 

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    Event date: 2001

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  82. Primary carer in household with less level of Informal Support Network is more depressive. International conference

    International Society for Quality of Life Research Pan-Pacific Conference (Tokyo, Japan) 

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    Event date: 2001

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  83. Long-term weight gain predicts clustering of cardiac risk factors. International conference

    The 5th International Conference on Preventive Cardiology (Osaka, Japan) 

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    Event date: 2001

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  84. A cross-sectional study on factors related to hypertension with special reference to gender difference in Japanese workers. International conference

    The 5th International Conference on Preventive Cardiology (Osaka, Japan) 

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    Event date: 2001

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  85. Family history and the risk of stomach cancer death in Japan: Differences by age and sex. International conference

    The 3rd Asian-Pacific Congress of Epidemiology (Kitakyushu, Japan) 

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    Event date: 2001

    Language:English  

  86. A prospecive study of stomach cancer and its relation to green tea consumption in Japan. International conference

    The 3rd Asian-Pacific Congress of Epidemiology (Kitakyushu, Japan) 

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    Event date: 2001

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  87. 多施設検査データ統合疫学研究における外部精度管理調査結果の利用

    八谷寛、玉腰浩司、近藤高明、他7人(1番目).

    第46回東海公衆衛生学会(岐阜) 

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    Event date: 2000

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  88. 職域コホートのベースラインデータにおける諸種生活習慣病と食習慣の関係

    八谷寛、玉腰浩司、堀 容子、他8人(1番目).

    第10回日本疫学会総会(米子) 

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    Event date: 2000

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  89. Possible change in dietary pattern with awareness of elevated serum cholesterol level-an indirect association seen in a cross-sectional study. International conference

    The XV International scientific meeting of the international epidemiological association (Florence, Italy) 

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    Event date: 1999

    Language:English   Presentation type:Poster presentation  

  90. 障害調整生存年DALY(Disability-Adjusted Life Year)による日本の総疾病負担の推定

    八谷寛、福田吉治、長谷川敏彦、田端航也他.

    第69回日本衛生学会総会(千葉) 

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    Event date: 1999

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  91. 職域コホートを用いた生活習慣病の発症に関する調査 -食習慣と血清脂 質の関係-

    八谷寛、堀容子、豊嶋英明他.

    第9回日本疫学会総会(名古屋) 

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    Event date: 1999

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  92. 新興再興感染症の現状と日本の状況(preparedness)

    八谷寛、豊嶋英明、宮尾克他.

    第13回日本国際保健医療学会(大阪) 

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    Event date: 1998

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  93. 発展途上国における下痢症の現状とその対策について

    八谷寛

    第39回社会医学研究会総会(名古屋) 

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    Event date: 1998

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  94. The association of work-related stress with aggravation of pre-existing disease during COVID-19 emergency in Japan International conference

    He Yupeng, Yatsuya Hiroshi, Chiang Chifa, Ota Atsuhiko, Okubo Ryo, Ishimaru Tomohiro, Tabuchi Takahiro

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY  2021.9 

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    Language:English   Presentation type:Oral presentation (general)  

    DOI: 10.1093/ije/dyab168.273

  95. MEASURES OF LONG-TERM SYSTOLIC BLOOD PRESSURE VARIABILITY AND THEIR ASSOCIATIONS WITH THE RISK OF INCIDENT TYPE 2 DIABETES MELLITUS International coauthorship International conference

    Song Zean, He Yupeng, Chiang Chifa, Alshoaibi Abubakr A. A., Rahman K. M. Saif Ur, Mamun Md Razib, Aoyama Atsuko, Hirakawa Yoshihisa, Matsunaga Masaaki, Ota Atsuhiko, Tamakoshi Koji, Li Yuanying, Yatsuya Hiroshi

    JOURNAL OF HYPERTENSION  2023.1 

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    Language:English   Presentation type:Oral presentation (general)  

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Research Project for Joint Research, Competitive Funding, etc. 21

  1. 循環器疾患及び糖尿病、 COPD 等の生活習慣病の個人リスク及び集団リスクの評価ツールの開発と応用のための研究

    Grant number:23FA1006  2023.4

    循環器疾患・糖尿病等生活習慣病対策総合研究事業  厚生労働科学研究費補助金

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    Authorship:Coinvestigator(s) 

  2. 心身機能のエイジングに着目した高齢期の就労支援に関する研究

    Grant number:23JA1006  2023.4

    労働安全衛生総合研究事業  厚生労働科学研究費補助金

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    Authorship:Coinvestigator(s) 

  3. 多目的コホートに基づくが ん予防など健康の維持・増進に役立つエビデンスの構築に関する研究 International coauthorship

    Grant number:2020-J-4  2020.5 - 2021.3

    国立がん研究センター研究開発費 

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    Authorship:Coinvestigator(s)  Grant type:Other

    Grant amount:\250000

  4. 生涯にわたる循環器疾患の個人リスクおよび集団リスクの評価ツールの開発及び臨床応用のための研究

    Grant number:20316311  2020.4 - 2023.3

    厚生労働科学研究費補助金  循環器疾患・糖尿病等生活習慣病対策総合研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\750000 ( Direct Cost: \750000 )

  5. 涯にわたる循環器疾患の個人リスクおよび集団のリスク評価ツールの開発を目的とした大規模コホート統合研究

    Grant number:17933083  2017.4 - 2020.3

    厚生労働科学研究費補助金  循環器疾患・糖尿病等生活習慣病対策総合研究事業

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    Authorship:Coinvestigator(s) 

    Grant amount:\4650000 ( Direct Cost: \4650000 )

  6. 保健関連ポストMDG課題としてのNoncommunicable Disease (NCD)-オセアニア・南アジア・アフリカにおけるNCD対策推進のための学際的研究 International coauthorship

    Grant number:15545398  2015.4 - 2018.3

    日本医療研究開発機構研究費  地球規模保健課題解決推進のための研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  7. 生活習慣病予防のための宿泊を伴う効果的な保健指導プログラムの開発に関する研究

    Grant number:15652746  2015.4 - 2017.3

    循環器疾患・糖尿病等生活習慣病対策実用化研究事業  循環器疾患・糖尿病等生活習慣病対策実用化研究事業(委託事業)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  8. 循環器疾患における集団間の健康格差の実態把握とその対策を目的とした大規模コホート共同研究

    Grant number:14427346  2014.4 - 2017.3

    厚生労働科学研究費補助金  循環器疾患・糖尿病等生活習慣病対策政策研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4000000 ( Direct Cost: \4000000 )

  9. 生活習慣病予防のための宿泊を伴う効果的な保健指導プログラムの開発に関する研究

    Grant number:14533117  2014.4 - 2015.3

    厚生労働科学研究費補助金  循環器疾患・糖尿病等生活習慣病対策実用化研究事業(委託事業)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  10. 脂肪細胞機能調節性マイクロRNAと肝脂肪蓄積との関連

    2014

    学術研究振興資金 

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    Grant amount:\3000000

  11. 東アジア、オセアニアにおける生活習慣病対策推進のための学際的研究 International coauthorship

    Grant number:13802126  2012.4 - 2015.3

    厚生労働科学研究費補助金  地球規模保健課題解決推進のための行政施策に関する研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  12. 潜在性動脈硬化と新規血清指標の疫学研究

    2012

    研究推進特別奨励金 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4000000 ( Direct Cost: \4000000 )

  13. 一般集団におけるMagnetic Resonance Spectroscopyによる異所性脂肪蓄積定量化-生活習慣と脂肪分布異常から見た肥満関連代謝異常の疫学的病態解明-

    2007 - 2008

    千代田健康開発事業団 

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    Grant type:Competitive

  14. メタボリックシンドローム予防における血清アディポネクチン濃度測定の意義

    2006

    名古屋公衆医学研究所 

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    Grant type:Competitive

  15. アディポネクチンと代謝異常症候群との関連

    2004 - 2006

    上原記念生命科学財団研究奨励金 

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    Grant type:Competitive

  16. 性差を考慮した生活習慣病発症メカニズムの疫学的病態解明

    2004 - 2005

    愛知健康増進財団 

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    Grant type:Competitive

  17. 生活習慣病発症予防に関する職域コホート研究-職場におけるストレスと炎症マーカーとの関連-

    2004 - 2005

    公益信託動脈硬化予防研究助成金 

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    Grant type:Competitive

  18. 肥満者における心血管疾患発症の過剰リスクを説明する新しい軸-レプチンと炎症反応の直接的関連-

    2003 - 2005

    財団法人健康管理事業団 

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    Grant type:Competitive

  19. レプチン抵抗性に基づく肥満の疫学的病態解明

    2003 - 2004

    財団法人明治生命厚生事業団 

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    Grant type:Competitive

  20. 生活習慣病発症予防に関する職域コホート研究-血清レプチン値と体重変化との関連-

    2003 - 2004

    公益信託動脈硬化予防研究助成金 

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    Grant type:Competitive

  21. 生活習慣病発症予防に関する職域コホート研究-インスリン濃度と危険因子集積の検討-

    2002 - 2003

    公益信託動脈硬化予防研究助成金 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 31

  1. 人工甘味料と生活習慣病の関連:疫学研究からのエビデンスと作用機序の包括的解明

    Grant number:24K02692  2024.4 - 2028.3

    科学研究費助成事業  基盤研究(B)

    山田 宏哉, 鈴木 康司, 八谷 寛, 宗綱 栄二, 山崎 未来, 坪井 良樹, 安藤 嘉崇

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    Authorship:Coinvestigator(s) 

    人工甘味料の使用が世界中で急増している。しかしながら、人工甘味料の安全性や長期的な健康への影響については、不明な点が多く、人類が解決するべき喫緊の課題のひとつである。本研究は、「人工甘味料が生活習慣病に与える影響とその作用機序の解明」を目的とする。一般住民を対象とした疫学研究により生活習慣病との関連を評価し、動物・細胞培養実験により作用メカニズムの解明を目指す。本研究は疫学と基礎研究を統合し、人工甘味料の潜在的リスクを包括的に解析する。

  2. The relationship between chronotype and obesity and depression: Mendelian randomization analysis

    Grant number:24K13438  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  3. Worsening of chronic condition during COVID-19 pandemic and association of occupational factors with the incidence of cardiovascular diseases in workers with chronic condition

    Grant number:22H03349  2022.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

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  4. Worsening of chronic condition during COVID-19 pandemic and association of occupational factors with the incidence of cardiovascular diseases in workers with chronic condition

    Grant number:23K24607  2022.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

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  5. Psychosocial work characteristics and musculoskeletal disorders in childcare workers: A prospective cohort study

    Grant number:19K10631  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ota Atsuhiko

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    Low back pain (LBP) is a common work-related musculoskeletal disorder in childcare workers. The purpose of this study was to identify work-related psychosocial characteristics affecting LBP among them. A prospective cohort study with a 1-year observation period was conducted with 444 childcare workers. Among those who suffered from LBP at the baseline of the study, those who reported low social support from their supervisors and coworkers at work at the baseline were statistically 2.43 times more likely to suffer from LBP one year later than those who did not. Human relationships at work were shown to be a cause of persistent LBP in childcare workers.

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  6. Effects of work-family conflict on mental and cardiometabolic profiles and sleep disorders among Japanese and Egyptian civil workers International coauthorship

    Grant number:19K10621  2019.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Frag Ehab Salah Eshak

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    In the PY 2023, We published five research articles.1- A comparative study of the work-family conflicts prevalence, their sociodemographic, family, and work attributes, and their relation to the self-reported health status in Japanese and Egyptian civil workers : DOI:10.1186/s12889-022-13924-0. 2-The mediating role of work-family conflicts in the association between work ability and depression among Egyptian civil workers: DOI:doi: 10.1007/s10935-022-00690-3. 3-Work and Family Conflicts, Depression, and "Ikigai": A Mediation Analysis in a Cross-Cultural Study Between Japanese and Egyptian Civil Workers. doi: 10.2188/jea.JE20210338. 4-Minimal Contribution of the Social Determinants of Health to the Prevalence of Hypertension among Egyptian Public Servants. Curr Hypertens Rev. 2023. DOI: 10.2174/1573402119666230302090924 5-The prevalence and determining factors of sleep disorders vary by gender of the Egyptian public officials. DOI:10.1186/s42269-022-00927-5

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  7. 救急外来で急性心筋梗塞の安全な除外を支持するトロポニンとリスクスコアの実証研究

    Grant number:18K08902  2018.4 - 2024.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    岩田 充永, 八谷 寛, 寺澤 晃彦

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    86件の救急外来を受診した非ST上昇型心筋梗塞(NSTEMI)疑い患者に対し、高感度心筋トロポニン(hs-cTn)連続測定法によるNSTEMI診断あるいは30日予後予測を報告した研究でscoping reviewを実施した。大多数は欧州、北米、豪州等の特定グループからの報告で、アッセイはAbbott (43件, 50%)とRoche(53件, 62%)が多く、検査アルゴリズムは外来受診時とその数時間後の測定値から、NSTEMIリスクを層別化する方法がとられていた。83件(97%)は前向き研究だが、53件(62%)では検体紛失や最終診断不明から最高90%の患者が解析から除外されていた。特定グループの重複報告が多く、重複のない研究は42件(49%)、競合アッセイ間の直接比較研究はわずか19件(22%)であった。中年正常腎機能患者の結果が多く、腎障害患者のサブグループデータはわずか4件の報告であった。47件(55%)で欧州心臓学会推奨3群層別化アルゴリズムが採用されていた。アウトカムは84件(98%)で最新の心筋梗塞国際定義に準拠していたが、30日イベントは研究毎に異質で標準化はされなかった。本研究結果より、現存するhs-cTn連続測定法によるNSTEMI診断のエビデンスは中年腎機能正常患者からの結果が中心だが、実臨床では高齢者や腎機能障害患者は重要な対象患者層であり、結果の適用性に疑問が残る。また主要アッセイ2種以外の結果は依然限定的であり、アッセイ間の直接比較もデータは限られた。大多数が欧米の特定研究グループの結果と地域偏向があり、アジアからの報告は限られた。患者の研究からの除外頻度は決して無視できないものであり、報告されている結果自体がリアルワールドを正しく反映していない可能性が懸念された。本結果は英文国際誌に発表した(Ohtake H., BMJ Open 2022)。
    前年度までに報告の如く、本研究結果がhs-cTn連続測定法によるNSTEMI診断の現状の科学的証拠が不十分であることを批判的に評価した報告であるため、一連の投稿雑誌では不採用となり、査読後再投稿が可能と裁定を受けたBMJ Open誌にても極めて批判的な評価と論拠を支持する膨大な追加解析の指示が出され、これに対応する詳細な検索の追加とアップデート、必要項目のデータ抽出と再解析、改訂作業に時間を要した。この大きな改定終了後検査精度および予測精度自体のネットワークメタアナリシスを進めており、研究全体の進捗が遅れている状況である。
    一次研究のデータセットが確定し、引き続きネットワークメタアナリシスを進める。アッセイ(Abbott; Roche; Siemens; Beckmann; POC各アッセイ)、採血プロトコル(0h/1h-, 0h/2h- , および0h/3h-アルゴリズム)、検査アルゴリズムによるリスク層別群(高リスク群(Rule-in)、中リスク群、低リスク群(Rule-out))、から比較対象のコンポーネントを決定し、Owenらが報告したアーム別階層ベイズ2変量ランダム効果ネットワークメタアナリシス(Owen R et al. J ClinEpidemiol 2018)を実施して各個別方法の診断精度の違いを全体性の面から対応予定である。一次研究については潜在クラスモデル分析(不完全参照基準の側面から対応)、逆確率補正(欠落データの対応)、最新データから追跡法による追加補正を加え、ナイーブな横断的解析から生じる過大評価を定量化し、ネットワークメタアナリシスから得られた結果との違いも考察し、報告する予定である。

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  8. A life course worksite-based cohort study of frailty and participation from adulthood until after retirement

    Grant number:18H03057  2018.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    YATSUYA Hiroshi

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\17810000 ( Direct Cost: \13700000 、 Indirect Cost:\4110000 )

    The associations between lifestyle or health status during young adulthood to middle age and frailty or participation in the older age are not fully understood. The participants of the Aichi Workers’ Cohort Study who were retired and aged 60 to 79 and in 2018 were examined using Montreal Cognitive Assessment-Japanese (MoCA-J) and assessed for the presence of frailty using 2020 CHS criteria. Diabetes in middle age was independently associated with low total MoCA-J scores assessed later in life. The prevalence of frailty or pre-frailty was 35.8% in the studied participants.

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  9. 退職公務員におけるフレイルと社会参加に関する在職時からのライフコース疫学研究

    2018.4 - 2021.3

    文部科学省  科学研究費補助金(基盤研究(B)) 

    八谷寛

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    Authorship:Principal investigator  Grant type:Competitive

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  10. Development of measures for occupational and clinical doctors to cooperate, share information, and support cancer survivors' return to work

    Grant number:16K09111  2016.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Atsuhiko Ota

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    Authorship:Coinvestigator(s) 

    (1) We conducted a systematic review and found the return-to-work ratios of about 60-80% among Japanese cancer survivors. (2) We conducted a cross-sectional study and found a low level of functional capacity and self-rated health status among Japanese cancer survivors who returned to work. (3) We conducted a systematic review and found that return to work was not an absolute solution for preventing depression among cancer survivors. (4) We conducted a cross-sectional study and found that information was not well distributed in worksites in Japan regarding the cancer survivors’ working while taking treatment for cancer and the appropriate working conditions and labor management. (5) Based on these research results, we propose the ways of cooperating, sharing information, and supporting cancer survivors’ return to work by occupational and clinical doctors.

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  11. The association between objective and subjective measures of residence neighborhood environment and leisure-time physical activities

    Grant number:16K19278  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Yuanying LI, Hanibuchi Tomoya, Yatsuya Hiroshi, Ota Atsuhiko, Kitajima Tsuyoshi

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    The current cross-sectional research examined the relationship of geographic information system measured residential neighborhood walkability, and the numbers of parks or green space and sports facilities in current as well as retired local government workers in Aichi prefecture with self-reported leisure-time physical activity habits. Perception of residential environment was also obtained from retirees. The study subjects were restricted to those residing in urban-suburban area around Nagoya.
    We found that higher residential neighborhood walkability was associated with having moderate to vigorous exercise habits defined as 3-4 times or more per week during leisure-time in working women. Higher residence neighborhood walkability, greater numbers of parks or green space, and positive perceptions about one’s neighborhood environment were associated with habitual walking defined as 3-4 times or more per week in male and female retirees.

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  12. The stress reaction that a nursing science bedside teaching gives to the health of the nursing student, a lifestyle and endocrine system

    Grant number:15K11530  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Morita Mamiko

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    Authorship:Coinvestigator(s) 

    Practice stressors were seen as "I do not understand the contents" "busy" "physical and mental exhaustion" "leaders, teachers, members and do not go well". There was no significant correlation between the stress score and the sleeping time in relation to the stress response, but there was a significant decrease in sleeping time and a significant increase in those who complained of early morning awakening. Practice stress is thought to affect sleep quality. Also, in the psychological stress load test, although it rose somewhat from the immediately after 15 minutes, it was recovered to the previous value in 60 minutes, so the need to intervene immediately after receiving the stimulation was considered. Therefore, it was suggested that it was necessary to confirm not only before and after practical training but also detailed reaction during practical training.

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  13. Applicability of Web-based dietary assessment system for a large-scale epidemiological study.

    Grant number:15H02906  2015.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Takachi Ribeka

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    Food frequency questionnaire (FFQ) has been used for the dietary assessment in many epidemiological studies. There is a growing need for detailed-assessment tool which simultaneously reduce the total burden of studies on the basis of technology innovation. Online system offer advantages over printed questionnaires, such as the automatic and direct data storage of answers. We examined the utilization of Web-based tool by comparison of the validity of dietary intake by Web-FFQ with those by print-FFQ. Online system is a reasonably valid measure like the printed FFQ. Further, we developed an automated-, web-based assessment system using recipe-data for Japanese (AWARDJP) based on Automated Multiple-Pass Method (AMPM, by USDA). Improvement of some processes such as selecting dishes were required in a pilot study. The detailed-dietary survey using AWARDJP was started for sub-sample of large scale cohort study, and approximately 1,600 day sample among 1,000 participants were collected.

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  14. Spatial and genetic epidemiological study on the pathogenesis of obesity and diabetes

    Grant number:26293153  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Yatsuya Hiroshi, HANIBUCHI Tomoya, TOYOSHIMA Hideaki, CHIANG Chifa, YAMASHITA Kentaro, WANG Chaochen, ZHANG Yan, KANEKO Kayo, AL-SHOAIBI Abubakr Ahmed Abdullah, GEBREMARIAM Lemlem Weldegerima, HE Yupeng, SUZUKI Koji, SAYEED Shurovi, KATOH Yoshiji, FUJISAWA Akiko, MATSUNAGA Masaaki, KHINE May Thet

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\16770000 ( Direct Cost: \12900000 、 Indirect Cost:\3870000 )

    The associations of a neighborhood’s built environment on health via its effects on physical activity, diet, or other unknown mediators have been suggested, but little studied in Japan. A composite measure of geographic characteristics, walkability index, was obtained in the present study using geographic information system (GIS), which consists of population density, road density, access to parks, and access to retail areas (Hanibuchi, et al., 2015). As the results, the degree of residence neighborhood walkability was associated with self-reported leisure-time physical activities among workers living in an urban-suburban area. Also, distance between one's home and the workplace was positively associated with self-reported duration of walking.

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  15. Approach from physiological functions in mechanisms of stress, quality and quantity of sleep and sense of well-being.

    Grant number:26350876  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Iida Tadayuki

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    The percentage of people with work- and life-related anxiety, worry, and stress is increasing every year, and it is said to exceed 60%. The relationship between psychological stress and oxidative stress has become a focus of interest, and the mechanism by which psychological stress increases reactive oxygen species (ROS) is slowly being elucidated. This study focused on [Association between the Profile of Mood States and Autonomic Nervous System Activity during Sleep] and [Effects of psychological stress on the urine 8-hydroxy-deoxyguanosine levels in young female students, taking into account the menstrual cycle]. Mood changes showed an association with sympathetic and parasympathetic nervous system activities during sleep, suggesting the possibility of these activities influencing moods.This study also showed that U8-OHdG levels increased with the psychological stress of a national license examination.

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  16. アフリカ低所得国の地方都市・農村部における生活習慣病の実態と危険因子の学際的解析

    Grant number:26293147  2014.4 - 2017.3

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    青山 温子, 平川 仁尚, 江 啓発, 八谷 寛, ESAYAS Hilawe

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    エチオピア北部ティグレイ県、メケレ市の公務員(地方都市部)およびキルテアウラエロ郡住民(農村部)から、男女、職種、年齢で分けた、計8グループのフォーカスグループディスカッションを行なった。同意を得た後、ティグレイ語で、健康に関する意識・行動、食習慣をはじめとする生活習慣、伝統的慣習、家庭での意思決定などについて話しあってもらい、録音を書き起し、逐語的に英訳した。平成26年度に実施した、キーインフォーマントインタビューで得られたデータと合わせて、英語のテキストデータを質的分析した。
    当初は、都市部と農村部において、各1000名を対象とした疫学調査を行なう計画であったが、旱魃により農村が困窮しており、農村での調査協力を得ることが困難となったため、都市部公務員のみを対象とすることに変更した。メケレ市内の省庁を訪問して調査目的等を説明し、同意の得られた者を対象として、WHO-STEPSに準じた方法で疫学調査を行なった。一部改訂した標準質問票による面接調査の後、省庁の会議室や講堂にポータブル機器を設置して、標準化された方法で、身長、体重、腹囲、腰囲、血圧測定した。末梢血を採血して、空腹時血糖、コレステロール、HDLコレステロール、中性脂肪、HbA1cを測定した。最終的に、1527名が調査に参加した。得られたデータを匿名化して入力し、データベース化した。

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  17. Research on non-communicable diseases and social risk factors among migrant laborers and the poor in South Asia and Oceania

    Grant number:25257505  2013.10 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Aoyama Atsuko, Sherilynn Madraisau, Edolem Ikerdeu, Bernie Ngiralmau, Berry Moon Watson, Singeru Travis Singeo, Jr, Gregorio Ngirmang, Faustina Rehuher Marugg, Julita Tellei, Patrick Tellei, Md. Khalequzzaman, Sohel Reza Choudhury, Bilqis Amin Hoque, Fariha Haseen, Syed Shariful Islam, Mohammad Abdullah Al-Mamun, Shahrin Emdad Rayna, Fahmida Afroz Khan, UEMURA Mayu, WANG Chaochen, OSAKO Ayaka, Abubakr Ahmed Abdullah Al-Shoaibi, ZHANG Yan, Lemlem Weldegerima Gebremariam, HE Yupeng, CUI Renzhe, SATA Mizuki, CUI Meishan, OUCHI Shino

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    We conducted epidemiological surveys and qualitative studies regarding noncommunicable disease (NCD) risk factors, targeting migrant foreign workers in Palau and residents of an urban poor community in Bangladesh. We found that the prevalence of overweight was lower in the Filipinos in Palau than the Paluans. In Bangladesh, both underweight and overweight were prevalent among the urban poor men but overweight was highly prevalent among the women. The prevalence of diabetes based on HbA1c values was much higher than the WHO estimated prevalence based on the values of fasting blood glucose. The qualitative study showed that the poor community people perceived poverty was the main cause of NCD and their daily diets might be unhealthy. They were willing to improve their health and women groups walked early in the morning for their health.
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  18. Epidemiologic study on the origin of lifestyle-related disease: the combined effect of intrauterine environment and lifestyle after birth.

    2011.4 - 2015.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(C)

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    We conducted the epidemiologic study to elucidate the combined effect of intrauterine environment and lifestyle after birth on the development of lifestyle-related disease. Birth weight was used as an index of intrauterine environment. In this study, the combined effect of birth weight and smoking behavior on the development of type 2 diabetes was examined. The subjects born with less than 2500g had a significant high risk of type 2 diabetes independent of smoking behavior after birth. The subjects with smoking history had a higher risk of type 2 diabetes than those with no smoking history in each birth weight group. Interestingly the subjects who were born with 3500g and over and had smoking history presented a similar high risk of type 2 diabetes to those born with less than 2500g.

  19. Worksite-based cohort study on risk factors for non-communicable disease in Japan

    Grant number:22390133  2010.4 - 2014.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

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    Authorship:Principal investigator  Grant type:Competitive

    We carried out a worksite-based cohort study in an attempt to identify risk factors and novel markers of cardiovascular disease in recent Japanese population. Civil servants of a local government located in central Japan (n=6,648) were followed, and 59 incident coronary heart diseases, 47 strokes, 430 diabetes, and 1,599 hypertension were ascertained during the entire observation period (approximately 10 years). Overweight, hypertension, and current smoking were significantly positively associated with higher incidence of cardiovascular disease. Low adiponectin and high CRP blood levels, current smoking, breakfast skipping, and positive family history were associated with higher diabetes incidence. Novel biomarkers were obtained by AlphaLISA. We also performed questionnaire survey and collected additional blood and urine sample for the remaining and new cohort participants (n=6,046).

  20. MRSによる異所性脂肪蓄積定量化-有効な生活習慣病予防に向けて-

    Grant number:20790438  2008.4

    日本学術振興会  科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator  Grant type:Competitive

  21. The prevention of lifestyle-related disease based on the fetal origins of adult disease (FOAD) hypothesis-creation of evidence for the practical use-

    2008 - 2010

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(C)

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    The association of birth weight and eating speed with obesity in adulthood was examined among 1978 men and 537 women. In both men and women, the eating speed of those with low birth weight was fast. In men with low birth weight, eating fast tended to lead to obesity. In women, the positive association between eating speed and obesity was not modified by birth weight.

  22. Elucidation of the pathophysiology of lifestyle-related disease and new approach for its prevention verification and development of fetal origin hypothesis

    2006 - 2007

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(C)

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    We studied a workplace population of 3,053 Japanese (2,285 men and 768 women) aged 35 to 66 years in Aichi Prefecture, Japan, who responded to a self-reported questionnaire including medical history, medication use, lifestyle characteristics, and birth weight. They underwent a physical examination including height, weight, and blood pressure, and provided the data on all the components of the metabolic syndrome (MS) . Multi-adjusted odds rations of MS are 1.45, 1.05, 1.04, and 1.00 (reference) in birth weight categories of <2,500, 2,500-<3,000, 3,000-<3,500, 3,500-g, respectively. Overall, the subjects with birth weight of <2500g were likely to have a high prevalence of MS, but there was no significant association between birth weight and MS. To assess the effect modification of obesity (BMI >=25kg/m2) on the association between birth weight and MS, the present subjects were classified as either below or above BMI 25kg/m2. The inverse linear trends in the ORs for the presence of MS according to birth-weight category were statistically significant only among subjects with BMI >=25kg/m2. Among subjects with BMI <25kg/m2, the subjects with birth weight of <2500g were also likely to have a high prevalence of MS though statistically not significant We compared ORs for having at least two out of 4 MS components other than obesity among the eight categories of birth-weight/current BMI combinations. When the subjects with high birth weight(>=3,500g)and non-obese(BMI of <25kg/m2), the multi-adjusted OR of subjects with low birth weight (< 2,500g) and non-obese was 2.30. The obese subjects had a significantly higher prevalence of MS and the highest multi-adjusted OR (5.06, 95% confidence interval : 2.38-10.8)was observed among the subjects with low birth weight(<2,500g) and obese (BMI of >=25kg/m2) .

  23. アディポサイトカインによる生活習慣病予防パラダイムの展開

    Grant number:17790384  2005 - 2007.3

    日本学術振興会  科学研究費補助金  若手研究(B)

    八谷 寛

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    Authorship:Principal investigator  Grant type:Competitive

  24. 食事負荷に対する反応から見た、アディポネクチンの生理的意義

    2005 - 2006

    科学研究費補助金 

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    健康成人男性10人を対象に、平成17年度に実施した高炭水化物食・高蛋白質食負荷試験のデータを解析した。アディポネクチン、高分子量アディポネクチン、レプチン、インスリン、血糖、高比重リポ蛋白コレステロール、低比重リポ蛋白コレステロール、中性脂肪、レムナントリポ蛋白コレステロール、血管内皮前駆細胞(EPC)について、食事前、食後1、3、5時間後の変化ならびに、その変化の2食事間における差違に着目して解析した。まず、本研究の主題である(高分子量)アディポネクチンの食事負荷に対する変化を検討した。結果的に、アディポネクチンは、両食事負荷前後で変化せず、われわれの仮説は否定された。この摂食に影響されないアディポネクチンの特性は、検診などにおける生活習慣病のスクリーニングに用いる際に、逆に利点になると考えられる。われわれは、本萌芽研究とは別に、36時間の短期飢餓でも血中アディポネクチン濃度が変化しないことを確認しており、一つの論文にまとめて投稿すべく準備中である。脂質関連項目は両食事ともに著明な変化を認めなかったが、血糖値、インスリンは高炭水化物食で顕著に上昇した。レプチンは両食事ともに摂食後1、3時間後に一旦低下したあと、5時間後に負荷前値に戻った。最も興味深かったのは、食事摂取後にEPCが有意に低下したことである。われわれの予想に反して、高蛋白質食摂取後にその傾向が顕著であった。最近注目されている食後高血糖、食後高脂血症に加えて、本研究で認められた食後EPC数低下もまた、動脈硬化初期変化に関与する食後体内環境変化の一つとして重要と考えられる。この結果を、2007年3月16日、神戸で開催された日本循環器学会学術集会で発表した(PJ-310)。

  25. Workers' cohort study for the prevention of lifestyle-related diseases

    2005 - 2006

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

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    Based on the data of questionnaire survey of the workers' lifestyles in 1997 and 2002, effects of perceived mental stress on cardiovascular risk factors were analyzed1. Among four choices of answers, i.e., "very much", "much", "ordinary", and "little" to the question "Do you have much stress in your life?," the proportional rates of 6 items of job strain, overwork, sleep and exercise habits, and presence of confidants were compared and statistically significant, reasonable relationships were obtained in men (n=5,159) and women (n=1,468).2. In 1,062 male workers, serum leptin concentration was shown to increase significantly along with the increase of perceived stress after age, BMI, and lifestyles were statistically adjusted.3. The effects of perceived stress and physique of five years duration on blood pressure were examined in 1,673 male workers. In the 2 way ANOVA, main effect of physique and interaction between stress were significant. In the group which kept obese, both systolic and diastolic blood pressure became higher along with the increase of stress, while they became lower in the group which kept normal or lean weight.4. In 2,144 male workers, compared with the group which perceived lesser stress and did not eat to satiety, the increment of BMI during five years was not significant in the groups in which either one of much stress or satiety eating was present, but was significant in the group both factors were present after age, BMI in 1997, and exercise, smoking, and drinking habits were adjusted. The proportion of satiety eater became significantly greater as the perceived stress became greater.5. In January of 2007, developments of lifestyle-related diseases were surveyed by self-administered questionnaire in 11,256 workers and 671 people who retired. Analyses to investigate factors developing diseases will be done.6. Relationship between leptin concentration and blood pressure and the role of adiponectin in the development of metabolic syndrome were examined.

  26. Epidemiological elucidation of the pathogenesis of lifestyle-related disease and preventive measures in consideration of sex difference

    2004 - 2005

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(C)

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    We found that lifestyle was significantly associated with health condition in Japanese men whose lifestyles were different from those of the occidentals. However, the association was not observed among Japanese women. The difference could be explained by the fact that women had more good lifestyles and more healthy condition than men. Multivariate analysis showed that taking care of eating habits were significantly and positively associated with health condition among men. In recent years, many people take interest in their own meal. Therefore, the intervention in eating habits may be effective in the improvement of health condition. However, the lifestyles which can be changed easily are differed among the individuals. Our results suggested that taking any health practice leads to good health condition. On the other hand, the relationship between healthy custom and health condition was not found among women. The age of 50 years-old was strongly related to female health condition. We should take measures against the lifestyle-related disease among postmenopausal women. As for this issue, we paid attention to adiponectin which is an adipocyte-derived plasma protein of 244 amino acids that has been discovered recently. Circulating adiponectin concentration is inversely correlated with body weight and the amount of fat mass, despite being solely derived from adipose tissue in humans. This inverse correlation has been suggested to be related to the origin of insulin resistance in obese subjects. Therefore, we evaluated the influence of menopausal status on the serum adiponectin concentration and investigate whether the contribution of adiponectin to insulin resistance is modified by menopausal status. The transition to menopause increases serum adiponectin concentrations. Moreover, adiponectin may play an important role in the development of an incipient insulin-resistant state after, rather than before, menopause.

  27. レプチン抵抗性に基づく肥満及びリスクファクター集積の疫学的病態モデル構築

    Grant number:15689011  2003 - 2004

    科学研究費補助金  若手研究(A),課題番号:

    八谷 寛

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    Authorship:Principal investigator  Grant type:Competitive

    (1)健康男性767人の5年間の体重変化とベースライン時血清レプチン値との関連をベースライン時のBMIと年齢を調整して調べたところ、両者に有意な関連は認められなかった。ヒトにおけるレプチン抵抗性の存在を示した結果であると考えられた。(2)ベースライン血清レプチン値と血圧値との関連をインスリン抵抗性のHOMA指数を考慮して検討したところ(男性2,017名)、インスリン抵抗性のない非肥満者においてのみ血圧値とレプチン値に有意な関連性が認められた。また、この関連性は拡張期血圧において特に強かった。レプチンの交感神経系亢進作用が示唆された。(3)白血球数を従属変数、レプチン値、年齢、BMI、身体活動量、飲酒習慣、喫煙習慣を独立変数とした重回帰分析において(男性1,082人、女性200名)、レプチン値と白血球数の間に有意で独立した関連が認められた(男性:標準化β=0.17、P<0.001、女性:標準化β=0.31、P<0.001)。肥満者でしばしば認められる白血球数の上昇は肥満者における高レプチン血症によって引き起こされているかもしれないことが示唆された。(4)40歳代の健康男性625名を対象とした分析において、個人ごとの体重変化を年齢に対して回帰させた直線周囲の標準偏差(Root-mean-square-error : RMSE)を用いて算出した20歳代からの体重変動と血清レプチン値との間には肥満度や体重変化の傾きと独立した有意な関連が認められ、レプチン値の個人差が長期的な体重変動によって規定されている可能性があることが示唆された。(5)自覚的ストレスがかなり多い、やや多い、ふつう、少ないの4群における血清レプチン値(ng/ml)はそれぞれ3.54、3.32、3.26、2.85と有意に異なり、この関連は肥満度や他の生活習慣と独立していた(男性1,129名)。自覚的なストレスが血清レプチン値を上昇させる作用があることが示唆された。

  28. Worksite cohort study for evaluation of lifestyle-related diseases risk : effect of lifestyle modification on the insulin level and the manifestation of metabolic syndrome

    2001 - 2004

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(B)

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    We started a worksite-based cohort study of 11,000 people in 1997 by constructing database consisting of annual health check-up data and affairs of coronary heart disease(CHD) and stroke under the approval of ethical committee. In 1997 and 2002,questionnaire survey on lifestyle and storage of frozen serum samples for later determination of insulin, leptin, CRP, etc was done.The following results were obtained, 1)Self-reported incident cases of CHD and stroke during the first 5 years accounted 52 and 36,respectively, including 15 myocardial infarctions, 14 angina pectoris, etc according to questionnaire survey. Consistency of the report with the answers from their family doctors was 100% for myocardial infarction, cerebral infarction and subarachnoid hemorrhage as long as cases examined under informed consent were concerned. Consistency for hypertension, diabetes, hyperlipidemia, and hyperuricemia all exceeded 95%. 2)The weight variability during 20 to 40 years since the age of 20 was a significant predictor of subsequent appearance of elevated serum insulin and CRP levels and metabolic syndrome(MS) independent of weight change slope or resultant BMI in 2,000 people, suggesting the importance of maintaining constant weight since the youth to prevent atherosclerosis. 3)Although the development of MS was associated with the increase in white blood cell(WBC) counts and CRP, insulin levels was not associated with the WBC counts in 3,500 people. Insulin, hence, was supposed to cause low grade inflammation or atherosclerosis through development of MS. Leptin was associated with the increase of WBC counts independently of obesity. 4)The association of blood pressure with likeness of salty taste was intensified in females aged 50 years or older, suggesting the effects of menopause on the salt sensitivity. 5)Serum phospholipids transfer protein showed strong correlations with serum lipids and BMI and an inverse correlation with the development of CHD but no correlation with that of stroke during 37 months' follow up of 2,600 people. 6)The reproducibility and validity of simple check-list type questionnaire of food intake and dietary behavior used in this study was confirmed. From the comparison of self-reported and measured weights at age 20,reliability of self-reported weights was confirmed.

  29. ミトコンドリア及び核遺伝子多型と生活習慣の生活習慣病発症に対する関連性の交互作用

    2001 - 2002

    科学研究費補助金 

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    「コホート研究による発がん要因の評価に関する研究(文部科学省)」において、同意を得て保存されたDNA試料1457人分について、「ヒトゲノム・遺伝子解析研究に関する倫理指針」を遵守し、β3アドレナリン受容体遺伝子、ミトコンドリア遺伝子(5178)、CYP1A1遺伝子、GSTM1遺伝子の各多型を判定し、その頻度、生活習慣との関連、追跡期間中の死亡リスクについて検討した。1990年のベースライン時から1999年までの追跡期間中の死亡者は1457人中119人、転出のため追跡不能者は22名であった。(1)多型の頻度・β3アドレナリン受容体遺伝子変異ホモ型のArg/Argは3.5%、ヘテロ型のTrp/Argは30.5%に認められた。・ミトコンドリア遺伝子で長寿に関連するとされる5178番目の塩基がAであるタイプは32.0%に認められた。・CYP1A1の3'側の変異型遺伝子(Msp I多型)の頻度はホモ型6.0%,ヘテロ型36.4%であった。・GSTM1の完全欠損型の頻度は52.1%であった。(2)多型と生活習慣・健診成績との関連・喫煙及び飲酒習慣と各多型には統計学的に有意な関連性は認められなかった。(3)多型と追跡期間中の死亡との関連・性別、年齢を調整したロジスティック回帰分析において、いずれの多型も追跡期間中の死亡とは有意な関連性は有さず、喫煙、飲酒を補正しても同様の結果が得られた。・CYP1A1*2A (Msp I多型)とGSTM1の完全欠損の有無によって4群に分類したところ、CYP1A1*2A-GSTM1欠損はCYP1A1*2A-GSTM1非欠損に比し、追跡期間中の死亡リスクが有意に低かった(前者の累積死亡率6.7%、後者の累積死亡率9.3% ; OR:0.48、95%CI:0.25-0.93)。

  30. レプチン、インスリン抵抗性に基づくマルチプルリスクファクター症候群の病態解明

    Grant number:13770192  2001 - 2002

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator  Grant type:Competitive

    本研究は、インスリン抵抗性及び高レプチン血症のどちらがより強くリスクファクター(RF)集積症候群と関連しているかを明らかにすることを目的とした。血清インスリン値及びレプチン値は、我々が1997年より追跡している職域コホート構成員のうち、高血圧、糖尿病、高脂血症の薬物治療者を除く空腹時採血を受けた男性(n=3748)からサンプリングした571名について、同年より保存されている健診時余剰血清を用いて測定した。Body-mass Index (BMI)と血清インスリン濃度(対数変換、以下インスリンと略す)、血清レプチン濃度(対数変換、以下レプチンと略す)との相関係数はそれぞれ0.56、0.69であった。またインスリンとレプチンの相関係数は0.59であった。収縮期血圧、血糖値、HDLコレステロール、トリグリセライドとインスリンとの相関係数は、それぞれ0.34、0.23、-0.28、0.31(いずれもP<0.01)であり、BMIを調整した偏相関係数はそれぞれ0.20、0.22、-0.17、0.22(いずれもP<0.01)であった。一方、これらとレプチンとの相関係数はそれぞれ0.31、0.14、-0.12、0.23(いずれもP<0.01)であり、BMIを調整した偏相関係数はそれぞれ0.11、0.11、0.09、0.08(前二者はP<0.01、HDLコレステロールはP<0.05、トリグリセライドはP=0.07)であった。RF集積数別のインスリン、レプチンの平均値(BMIを補正した調整幾何平均値)を一般線形モデルから求め、集積数による平均値の差を一元配置共分散分析により検定した。インスリン推定平均値は集積数が0、1、2、3個以上の順に4.32、4.90、5.74、6.67(F=20.6、P<0.001)であり、レプチン推定平均値は同様に3.06、3.00、3.34、3.27(F=3.3、P<0.05)であった。なお、BMI補正前のリスクファクター集積数のF値はインスリンでF=46.2、レプチンでF=19.8であった。インスリン、レプチンの両者ともRF集積症候群とBMIとは独立して関連していたが、その程度はインスリンにおいて強かった。このことは、レプチンの上昇がRF集積の結果である可能性も示唆するものであると考えられた。今後は、RF集積症候群において上昇したレプチン値がどのような生体影響を及ぼしているかの研究が必要であると考えられる。

  31. 大規模コホートによる胃がんの発生・死亡関連要因の探索

    2000 - 2001

    科学研究費補助金  特定領域研究

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    地域住民を対象とした大規模コホート調査(JACC Study)の調査票情報および保存血清および1997年末までの予後追跡調査データを用いて、胃がんのリスク要因を解析した。死亡を結果指標としたコホート解析では、胃がんリスクを高める要因として、短い教育歴、胃がん家族歴あり(男:RR,1.6;女:RR,2.5)、男の喫煙(RR,1.3;喫煙開始10-19歳:RR,1.9)、女性では生殖歴・出産歴がないこと、胃がん検診未受診(男:RR,2.0)があげられた。家族歴では、特に女で母親が胃がんの塙合に高いリスクを示した。また胃がんには家族集積性があることも示唆された。一方で、これまで胃がん関連要因として報告されてきた緑黄色野菜・高塩分含有食品・緑茶の摂取との関連は明らかでなかった。追跡期間別に分けた分析方法を用いると、干物類は、胃がんがあると摂取が減少する可能性が示唆された。また、コホート内症例対照研究の手法により、調査開始時に採取された血清を用いて、IGF、SOD、sFAS、TGF-b1の4項目を測定、胃がん罹患および死亡との関連を検討した。TGF-b1は、女性において、4分位で最も低い群にくらべ、値が高い群ほど胃がん罹患・死亡のリスクが上昇する量-反応関係を認めた。その他の3項目は、罹患と死亡で一致した傾向は認めなかった。同様の手法により、胃がんとの関連が強いとされる血清項目を測定した結果、Helicobactor pylori陽性のオッズ比は1.2、pepsinogen低値(胃粘膜萎縮あり)のオッズ比は1.9であった。H. pyloriのリスクが比較的低かったことの理由として、本解析集団が高齢であることが考えられる。現在、H. pyloriのCag-A抗体について測定を進めている。

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Teaching Experience (On-campus) 9

  1. 保健医療の仕組みと公衆衛生

    2020

  2. 基礎医学セミナー

    2020

  3. Community Health and International Health

    2020

  4. Environment and Health

    2023

  5. Applied Social and Behavioral Science

    2023

  6. Behavioral Science and Medical Anthropology

    2020

  7. 公衆衛生学

    2012

  8. 公衆衛生学

    2011

  9. Community Health

    2010

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Teaching Experience (Off-campus) 4

  1. 応用疫学

    2022.4 Aichi Prefectural University)

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    Level:Postgraduate 

  2. 公衆衛生学

    2012.7 - 2021.3 Fujita Health University)

  3. 保健予防医科学総論

    2012.4 - 2020.3 Chubu University)

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    Level:Undergraduate (specialized) 

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  4. 公衆衛生学

    藤田医科大学)

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Social Contribution 23

  1. 『実践する!高血圧予防』(医師に教わる高血圧予防

    Role(s):Lecturer

    愛知県岩倉市  健幸チャレンジ教室  2020.1

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    Audience: General

    Type:Lecture

  2. 予防を超える治療はないという健康教室

    Role(s):Lecturer

    豊田市  2019.6

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    Type:Visiting lecture

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  3. 就労世代における生活習慣病の実態と対策

    Role(s):Lecturer

    2019.4

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    Type:Certification seminar

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  4. 健康長寿の秘訣!健診結果はこう見る!

    Role(s):Lecturer

    愛知県岩倉市  岩倉市健幸チャレンジ教室「体の中から健康になるための教室」  2018.9

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    Audience: General

    Type:Lecture

  5. 健康長寿の秘訣!健診結果はこう見る!

    Role(s):Lecturer

    岩倉市  2018.9

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    Type:Lecture

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  6. 医学部模擬講義

    Role(s):Lecturer

    名古屋高校  2018.7

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    Type:Visiting lecture

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  7. 今日からできる簡単!生活習慣病予防

    Role(s):Lecturer

    愛知県豊田市  豊田市美里地域会議によるまちの保健室&健康づくり講演会  2018.2

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    Audience: General

    Type:Lecture

  8. 今日からできる簡単!生活習慣病予防

    Role(s):Lecturer

    豊田市美里地区  2018.2

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    Type:Lecture

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  9. 「わかっちゃいるけど、なかなかね…」というあなたのための、生活習慣病の予防

    Role(s):Lecturer

    豊明市  2018.1

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    Type:Lecture

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  10. 生活習慣病予防について

    Role(s):Lecturer

    愛知県豊明市  食生活改善推進員の養成講座  2017.11

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    Audience: General

    Type:Certification seminar

  11. 生活習慣病予防について

    Role(s):Lecturer

    豊明市食生活改善推進委員養成講座  2017.11

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    Type:Certification seminar

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  12. 健康長寿の秘訣! 健診結果はこう見る!

    Role(s):Lecturer

    愛知県岩倉市  健康寿命を延ばそう!健幸チャレンジ教室  2017.10

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    Audience: General

    Type:Lecture

  13. 健康長寿の秘訣!健診結果はこう見る!

    Role(s):Lecturer

    岩倉市健幸チャレンジ教室  2017.10

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    Type:Lecture

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  14. 健康長寿の秘訣!健診結果はこう見る!

    Role(s):Lecturer

    愛知県岩倉市  健康チャレンジ教室  2016.11

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    Audience: General

    Type:Lecture

  15. 健康長寿の秘訣!健診結果はこう見る!

    Role(s):Lecturer

    岩倉市健幸チャレンジ教室  2016.11

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    Type:Lecture

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  16. 健康寿命から考える

    Role(s):Lecturer

    愛知県北名古屋市  健康講座・健康セミナー  2016.6

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    Audience: General

    Type:Lecture

  17. 健康寿命から考える~明日も本当に元気でいられるの?~

    Role(s):Lecturer

    北名古屋市  2016.6

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    Type:Lecture

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  18. 健康長寿の秘訣!

    Role(s):Lecturer

    愛知県岩倉市  健康チャレンジ教室  2015.11

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    Audience: General

    Type:Lecture

  19. 伸ばそう健康寿命・続けよう健康習慣

    Role(s):Lecturer

    岩倉市メタボリック予防講演会  2014.11

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    Audience: General

    Type:Lecture

  20. 社員をがんでやめさせない!受けよう、受けさせよう「がん検診」

    Role(s):Lecturer

    愛知県半田保健所  地域職域連携講演会  2013.9

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    Audience: Company, Governmental agency

    Type:Lecture

  21. 職場における健康管理のポイント

    Role(s):Lecturer

    愛知県春日井保健所  地域職域連携講演会  2013.9

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    Audience: Company, Governmental agency

    Type:Lecture

  22. 健康日本21次期計画策定・推進に向けて~健康寿命延伸に向けた生活習慣病予防の視点から~

    Role(s):Lecturer

    愛知県春日井保健所  健康日本21あいち計画地域推進会議・講話  2013.2

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    Audience: Governmental agency

  23. 平成23年度産業医スキルアップ専門研修・職域におけるEBM・愛知職域コホート研究における成果

    2011.6

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Media Coverage 5

  1. 幼少期から予防と教育を 生活習慣病で学術会議提言 Internet

    47News 地方紙と共同通信のよんななニュース  2021.1

  2. 幼小児期から予防と教育を 生活習慣病で学術会議提言 Newspaper, magazine

    中部経済新聞  2020.11

  3. 脳梗塞を防ぐには!? TV or radio program

    テレビ愛知  データで解析!サンデージャーナル  2017.8

  4. あさイチ TV or radio program

    NHK総合  心疾患や脳卒中の発症確率がわかるという最新のインターネット診断の仕組みと根拠などを紹介  2016.6

  5. ニュース7 TV or radio program

    NHK総合  脳卒中リスクを知り予防に活用を  2013.3

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    Author:Other 

Academic Activities 13

  1. 提言:生活習慣病予防のための良好な成育環境・生活習慣の確保に係る基盤づくりと教育の重要性 International contribution

    Role(s):Supervision (editorial)

    日本学術会議第24期生活習慣病対策分科会  2020.8

  2. 幼小児期から思春期・若年成人期における生活習慣の見直しと健康増進 International contribution

    Role(s):Planning, management, etc., Panel moderator, session chair, etc.

    第76回日本公衆衛生学会総会・日本学術会議共催市民公開シンポジウム  2017.11

  3. 思春期から青年期の生活習慣の見直しと循環器病予防 International contribution

    Role(s):Planning, management, etc., Panel moderator, session chair, etc.

    日本循環器病予防学会(日本学術会議後援)  2016.6

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    Type:Competition, symposium, etc. 

  4. European Journal of Clinical Nutrition, Editor International contribution

    Role(s):Peer review

    2020.11

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    Type:Peer review 

  5. 提言:子ども・妊婦への受動喫煙対策をさらに充実させるべきである

    日本学術会議第24期脱タバコ社会実現分科会  2020.9

  6. Journal of Occupational Health, Associate Editor International contribution

    Role(s):Peer review

    2020.4

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    Type:Peer review 

  7. 日本産業衛生学会東海地方会学会(学会長) International contribution

    Role(s):Planning, management, etc.

    2019.12

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    Type:Competition, symposium, etc. 

  8. 第51回藤田学園医学会代表世話人

    Role(s):Planning, management, etc.

    藤田学園医学会  2019.10

  9. 働く世代の生活習慣病予防 ─健診・保健指導の今後の展開と若年期からの対策の重要性─

    日本学術会議第23期生活習慣病対策分科会  2017.9

  10. Journal of Epidemiology, Associate Editor

    Role(s):Peer review

    2017.1

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    Type:Peer review 

  11. 格差社会における健康問題の解決

    Role(s):Panel moderator, session chair, etc.

    第55回日本社会医学会  2014.7

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    Type:Competition, symposium, etc. 

  12. 社会的困窮者への公衆衛生からのアプローチ -現状と課題-

    Role(s):Planning, management, etc., Panel moderator, session chair, etc.

    第72回日本公衆衛生学会総会  2013.10

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    Type:Competition, symposium, etc. 

  13. Journal of Atherosclerosis and Thrombosis, Associate Editor

    Role(s):Peer review

    2012.10

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    Type:Peer review 

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