名古屋大学医学部小児科、医員

1997.10 - 1998.3

日本血液学会

日本癌学会

Single-Cell Transcriptomic Analysis of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis Reviewed

Suzuki, T; Sato, Y; Okuno, Y; Torii, Y; Fukuda, Y; Haruta, K; Yamaguchi, M; Kawamura, Y; Hama, A; Narita, A; Muramatsu, H; Yoshikawa, T; Takahashi, Y; Kimura, H; Ito, Y; Kawada, JI

JOURNAL OF CLINICAL IMMUNOLOGY   Vol. 44 ( 4 ) page： 103   2024.4

Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation Reviewed

Sagou, K; Sato, Y; Okuno, Y; Watanabe, T; Inagaki, T; Motooka, Y; Toyokuni, S; Murata, T; Kiyoi, H; Kimura, H

PLOS PATHOGENS   Vol. 20 ( 2 ) page： e1011954   2024.2

Updated guidelines for chronic active Epstein-Barr virus disease Reviewed

Kawada, JI; Ito, Y; Ohshima, K; Yamada, M; Kataoka, S; Muramatsu, H; Sawada, A; Wada, T; Imadome, KI; Arai, A; Iwatsuki, K; Ohga, S; Kimura, H

INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 118 ( 5 ) page： 568 - 576   2023.11

Growth Transformation of B Cells by Epstein-Barr Virus Requires <i>IMPDH2</i> Induction and Nucleolar Hypertrophy Reviewed International coauthorship

Sugimoto, A; Watanabe, T; Matsuoka, K; Okuno, Y; Yanagi, Y; Narita, Y; Mabuchi, S; Nobusue, H; Sugihara, E; Hirayama, M; Ide, T; Onouchi, T; Sato, Y; Kanda, T; Saya, H; Iwatani, Y; Kimura, H; Murata, T

MICROBIOLOGY SPECTRUM   Vol. 11 ( 4 ) page： e0044023   2023.8

Diagnostic and disease severity determination criteria for hydroa vacciniforme lymphoproliferative disorders and severe mosquito bite allergy Reviewed

Hirai, Y; Asada, H; Hamada, T; Kawada, J; Kimura, H; Arai, A; Ohshima, K; Ohga, S; Iwatsuki, K

JOURNAL OF DERMATOLOGY   Vol. 50 ( 7 ) page： E198 - E205   2023.7

Epstein-Barr Virus BBLF1 Mediates Secretory Vesicle Transport to Facilitate Mature Virion Release Reviewed

Uddin, MK; Watanabe, T; Arata, M; Sato, Y; Kimura, H; Murata, T

JOURNAL OF VIROLOGY   Vol. 97 ( 6 ) page： e0043723   2023.6

特集 新しい時代の小児感染症 各論:原因微生物別 ウイルス ヘルペスウイルス科 Invited

川田 潤一, 木村 宏

小児内科   Vol. 55 ( 4 ) page： 623 - 628   2023.4

Salvage Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplant With Posttransplant Cyclophosphamide for Graft Failure in a Patient With Chronic Active Epstein-Barr Virus Infection Reviewed

Nakaya, Y; Koh, H; Harada, N; Okamura, H; Misugi, T; Suekane, T; Tachibana, D; Kimura, H; Hino, M; Nakamae, H

EXPERIMENTAL AND CLINICAL TRANSPLANTATION   Vol. 21 ( 2 ) page： 184 - 188   2023.3

症例 CD8＋αβT細胞優位型種痘様水疱症リンパ増殖異常症の1例

大林 三裕佳, 中村 賢人, 古橋 卓也, 岩月 啓氏, 三宅 智子, 平井 陽至, 谷田 けい, 金兼 弘和, 西田 徹也, 木村 宏, 森田 明理

皮膚科の臨床   Vol. 65 ( 2 ) page： 273 - 278   2023.2

N6-methyladenosine Modification of Hepatitis B Virus RNA in the Coding Region of <i>HBx</i>

Murata, T; Iwahori, S; Okuno, Y; Nishitsuji, H; Yanagi, Y; Watashi, K; Wakita, T; Kimura, H; Shimotohno, K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 24 ( 3 )   2023.2

The 100<SUP>th</SUP> anniversary of the Nagoya Journal of Medical Science: a message from the Dean

Kimura, H

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 1 ) page： 5 - 6   2023.2

The Epstein-Barr Virus Enhancer Interaction Landscapes in Virus-Associated Cancer Cell Lines Reviewed International coauthorship

Ding Weiyue, Wang Chong, Narita Yohei, Wang Hongbo, Leong Merrin Man Long, Huang Alvin, Liao Yifei, Liu Xuefeng, Okuno Yusuke, Kimura Hiroshi, Gewurz Benjamin, Teng Mingxian, Jin Shuilin, Sato Yoshitaka, Zhao Bo

JOURNAL OF VIROLOGY   Vol. 96 ( 18 ) page： e0073922   2022.9

EBV-associated NK and T-cell lymphoid neoplasms. International coauthorship

Kimura H, de Leval L, Cai Q, Kim WS

Current opinion in oncology   Vol. 34 ( 5 ) page： 422 - 431   2022.9

Comprehensive Analyses of Intraviral Epstein-Barr Virus Protein-Protein Interactions Hint Central Role of BLRF2 in the Tegument Network International coauthorship

Hara Yuya, Watanabe Takahiro, Yoshida Masahiro, Al Masud H. M. Abdullah, Kato Hiromichi, Kondo Tomohiro, Suzuki Reiji, Kurose Shutaro, Uddin Md Kamal, Arata Masataka, Miyagi Shouhei, Yanagi Yusuke, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

JOURNAL OF VIROLOGY   Vol. 96 ( 14 ) page： e0051822   2022.7

Genome-wide CRISPR screen for HSV-1 host factors reveals PAPSS1 contributes to heparan sulfate synthesis

Suzuki Takeshi, Sato Yoshitaka, Okuno Yusuke, Goshima Fumi, Mikami Tadahisa, Umeda Miki, Murata Takayuki, Watanabe Takahiro, Watashi Koichi, Wakita Takaji, Kitagawa Hiroshi, Kimura Hiroshi

COMMUNICATIONS BIOLOGY   Vol. 5 ( 1 ) page： 694   2022.7

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms International coauthorship

Alaggio Rita, Amador Catalina, Anagnostopoulos Ioannis, Attygalle Ayoma D., Araujo Iguaracyra Barreto de Oliveira, Berti Emilio, Bhagat Govind, Borges Anita Maria, Boyer Daniel, Calaminici Mariarita, Chadburn Amy, Chan John K. C., Cheuk Wah, Chng Wee-Joo, Choi John K., Chuang Shih-Sung, Coupland Sarah E., Czader Magdalena, Dave Sandeep S., de Jong Daphne, Du Ming-Qing, Elenitoba-Johnson Kojo S., Ferry Judith, Geyer Julia, Gratzinger Dita, Guitart Joan, Gujral Sumeet, Harris Marian, Harrison Christine J., Hartmann Sylvia, Hochhaus Andreas, Jansen Patty M., Karube Kennosuke, Kempf Werner, Khoury Joseph, Kimura Hiroshi, Klapper Wolfram, Kovach Alexandra E., Kumar Shaji, Lazar Alexander J., Lazzi Stefano, Leoncini Lorenzo, Leung Nelson, Leventaki Vasiliki, Li Xiao-Qiu, Lim Megan S., Liu Wei-Ping, Louissaint Abner Jr., Marcogliese Andrea, Medeiros L. Jeffrey, Michal Michael, Miranda Roberto N., Mitteldorf Christina, Montes-Moreno Santiago, Morice William, Nardi Valentina, Naresh Kikkeri N., Natkunam Yasodha, Ng Siok-Bian, Oschlies Ilske, Ott German, Parrens Marie, Pulitzer Melissa, Rajkumar S. Vincent, Rawstron Andrew C., Rech Karen, Rosenwald Andreas, Said Jonathan, Sarkozy Clementine, Sayed Shahin, Saygin Caner, Schuh Anna, Sewell William, Siebert Reiner, Sohani Aliyah R., Tooze Reuben, Traverse-Glehen Alexandra, Vega Francisco, Vergier Beatrice, Wechalekar Ashutosh D., Wood Brent, Xerri Luc, Xiao Wenbin

LEUKEMIA   Vol. 36 ( 7 ) page： 1720 - 1748   2022.7

EBV genome variations enhance clinicopathological features of nasopharyngeal carcinoma in a non-endemic region

Kondo Satoru, Okuno Yusuke, Murata Takayuki, Dochi Hirotomo, Wakisaka Naohiro, Mizokami Harue, Moriyama-Kita Makiko, Kobayashi Eiji, Kano Makoto, Komori Takeshi, Hirai Nobuyuki, Ueno Takayoshi, Nakanishi Yosuke, Endo Kazuhira, Sugimoto Hisashi, Kimura Hiroshi, Yoshizaki Tomokazu

CANCER SCIENCE   Vol. 113 ( 7 ) page： 2446 - 2456   2022.7

Elderly-onset systemic Epstein-Barr virus-positive T-cell lymphoma of childhood

Nishikubo Masashi, Hiramoto Nobuhiro, Yamashita Daisuke, Imoto Hiroharu, Sato Yoshitaka, Okuno Yusuke, Haga Hironori, Nannya Yasuhito, Ogawa Seishi, Kimura Hiroshi, Ishikawa Takayuki

PATHOLOGY INTERNATIONAL   Vol. 72 ( 7 ) page： 376 - 378   2022.7

Epstein-Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infection International coauthorship

Sato, Y; Yaguchi, M; Okuno, Y; Ishimaru, H; Sagou, K; Ozaki, S; Suzuki, T; Inagaki, T; Umeda, M; Watanabe, T; Fujimuro, M; Murata, T; Kimura, H

CELL COMMUNICATION AND SIGNALING   Vol. 20 ( 1 ) page： 95   2022.6

EBV Exploits RNA m(6)A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle

Yanagi Yusuke, Watanabe Takahiro, Hara Yuya, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

FRONTIERS IN MICROBIOLOGY   Vol. 13   page： 870816   2022.6

PD-L1 upregulation by lytic induction of Epstein-Barr Virus.

Yanagi Y, Hara Y, Mabuchi S, Watanabe T, Sato Y, Kimura H, Murata T

Virology   Vol. 568   page： 31 - 40   2022.3

In Silico Analysis and Synthesis of Nafamostat Derivatives and Evaluation of Their Anti-SARS-CoV-2 Activity

Fujimoto Kazuhiro J., Hobbs Daniel C. F., Umeda Miki, Nagata Akihiro, Yamaguchi Rie, Sato Yoshitaka, Sato Ayato, Ohmatsu Kohsuke, Ooi Takashi, Yanai Takeshi, Kimura Hiroshi, Murata Takayuki

VIRUSES-BASEL   Vol. 14 ( 2 )   2022.2

Molecular Basis of Epstein-Barr Virus Latency Establishment and Lytic Reactivation International coauthorship

Murata Takayuki, Sugimoto Atsuko, Inagaki Tomoki, Yanagi Yusuke, Watanabe Takahiro, Sato Yoshitaka, Kimura Hiroshi

VIRUSES-BASEL   Vol. 13 ( 12 )   2021.12

A STING inhibitor suppresses EBV-induced B cell transformation and lymphomagenesis International coauthorship

Miyagi Shouhei, Watanabe Takahiro, Hara Yuya, Arata Masataka, Uddin Md. Kamal, Mantoku Keisuke, Sago Ken, Yanagi Yusuke, Suzuki Takeshi, Masud H. M. Abdullah Al, Kawada Jun-ichi, Nakamura Shigeo, Miyake Yasuyuki, Sato Yoshitaka, Murata Takayuki, Kimura Hiroshi

CANCER SCIENCE   Vol. 112 ( 12 ) page： 5088 - 5099   2021.12

Deletion of Viral microRNAs in the Oncogenesis of Epstein-Barr Virus-Associated Lymphoma

Kimura Hiroshi, Okuno Yusuke, Sato Yoshitaka, Watanabe Takahiro, Murata Takayuki

FRONTIERS IN MICROBIOLOGY   Vol. 12   page： 667968   2021.7

RNAseq analysis identifies involvement of EBNA2 in PD-L1 induction during Epstein-Barr virus infection of primary B cells Reviewed International coauthorship

Yusuke Yanagi, Yusuke Okuno, Yohei Narita, H M Abdullah Al Masud , Takahiro Watanabe , Yoshitaka Sato, Teru Kanda, Hiroshi Kimura, Takayuki Murata

Virology   Vol. 557   page： 44 - 54   2021.5

Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma. Reviewed

Takano G, Esaki S, Goshima F, Enomoto A, Hatano Y, Ozaki H, Watanabe T, Sato Y, Kawakita D, Murakami S, Murata T, Nishiyama Y, Iwasaki S, Kimura H.

Molecular Therapy – Oncolytics   Vol. 20   page： 220 - 227   2021.3

Role of Epstein-Barr Virus C Promoter Deletion in Diffuse Large B Cell Lymphoma Reviewed International coauthorship

Mabuchi Seiyo, Hijioka Fumiya, Watanabe Takahiro, Yanagi Yusuke, Okuno Yusuke, Al Masud H. M. Abdullah, Sato Yoshitaka, Murata Takayuki, Kimura Hiroshi

CANCERS   Vol. 13 ( 3 )   2021.2

Direct Evidence of Abortive Lytic Infection-Mediated Establishment of Epstein-Barr Virus Latency During B-Cell Infection Reviewed International coauthorship

Inagaki Tomoki, Sato Yoshitaka, Ito Jumpei, Takaki Mitsuaki, Okuno Yusuke, Yaguchi Masahiro, Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Kei, Iwami Shingo, Murata Takayuki, Kimura Hiroshi

FRONTIERS IN MICROBIOLOGY   Vol. 11   2021.1

Chronic active EB virus infection

Kimura Hiroshi

Journal of Hematopoietic Cell Transplantation   Vol. 10 ( 2 ) page： 87 - 93   2021

Oncolytic activity of HF10 in head and neck squamous cell carcinomas. Reviewed

Esaki S, Goshima F, Ozaki H, Takano G, Hatano Y, Kawakita D, Ijichi K, Watanabe T, Sato Y, Murata T, Iwata H, Shibamoto Y, Murakami S, Nishiyama Y, Kimura H

Cancer gene therapy   Vol. 27 ( 7-8 ) page： 585 - 598   2020.8

Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days Reviewed

Sato Yoshitaka, Iguchi Mitsutaka, Kato Yoshiaki, Morioka Hiroshi, Hirabayashi Aki, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yamada Kiyofumi, Kimura Hiroshi, Yagi Tetsuya

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page： 407-414   2020.8

Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification Reviewed

Yonese Ichiro, Sakashita Chizuko, Imadome Ken-Ichi, Kobayashi Tohru, Yamamoto Masahide, Sawada Akihisa, Ito Yoshinori, Fukuhara Noriko, Hirose Asao, Takeda Yusuke, Makita Masanori, Endo Tomoyuki, Kimura Shun-Ichi, Ishimura Masataka, Miura Osamu, Ohga Shouichi, Kimura Hiroshi, Fujiwara Shigeyoshi, Arai Ayako

BLOOD ADVANCES   Vol. 4 ( 13 ) page： 2918-2926   2020.7

A systemic form chronic active Epstein-Barr virus infection diagnosed from erythema nodosum-like skin lesions. Reviewed

Shibata A, Ishiguro Y, Makita S, Yamaga Y, Kimura H, Akiyama M

European journal of dermatology : EJD   Vol. 30 ( 3 ) page： 314-316   2020.6

Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting Reviewed International coauthorship

Cohena Jeffrey I., Iwatsuki Keiji, Ko Young-Hyeh, Kimura Hiroshi, Manoli Irini, Ohshima Koichi, Pittaluga Stefania, Quintanilla-Martinez Leticia, Jaffe Elaine S.

LEUKEMIA & LYMPHOMA   Vol. 61 ( 4 ) page： 808-819   2020.3

Oncogenesis of CAEBV revealed: Intragenic deletions in the viral genome and leaky expression of lytic genes Reviewed

Murata Takayuki, Okuno Yusuke, Sato Yoshitaka, Watanabe Takahiro, Kimura Hiroshi

REVIEWS IN MEDICAL VIROLOGY   Vol. 30 ( 2 ) page： e2095   2020.3

Antitumor activity of CDK inhibitor alsterpaullone in Epstein-Barr virus-associated lymphoproliferative disorders. Reviewed International coauthorship

Watanabe T, Sato Y, Masud HMAA, Takayama M, Matsuda H, Hara Y, Yanagi Y, Yoshida M, Goshima F, Murata T, Kimura H

Cancer science     2020.1

Epstein-Barr Virus BBRF2 Is Required for Maximum Infectivity

Al Masud H. M. Abdullah, Yanagi Yusuke, Watanabe Takahiro, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

MICROORGANISMS   Vol. 7 ( 12 )   2019.12

NK-cell post-transplant lymphoproliferative disease with chronic active Epstein-Barr virus infection-like clinical findings.

Iemura T, Kondo T, Hishizawa M, Yamashita K, Kimura H, Takaori-Kondo A

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     2019.8

Editorial: Epstein-Barr Virus-Associated T/NK-Cell Lymphoproliferative Diseases

Fujiwara Shigeyoshi, Kimura Hiroshi

FRONTIERS IN PEDIATRICS   Vol. 7 ( JULY ) page： 285   2019.7

Viral DNA loads in various blood components of patients with Epstein-Barr virus-positive T/NK cell lymphoproliferative diseases.

Kawada JI, Kamiya Y, Sawada A, Iwatsuki K, Izutsu K, Torii Y, Kimura H, Ito Y

The Journal of infectious diseases     2019.6

The BOLF1 gene is necessary for effective Epstein-Barr viral infectivity

Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

VIROLOGY   Vol. 531   page： 114-125   2019.5

S-Like-Phase Cyclin-Dependent Kinases Stabilize the Epstein-Barr Virus BDLF4 Protein To Temporally Control Late Gene Transcription

Sato Yoshitaka, Watanabe Takahiro, Suzuki Chihiro, Abe Yuichi, Al Masud H. M. Abdullah, Inagaki Tomoki, Yoshida Masahiro, Suzuki Takeshi, Goshima Fumi, Adachi Jun, Tomonaga Takeshi, Murata Takayuki, Kimura Hiroshi

JOURNAL OF VIROLOGY   Vol. 93 ( 8 )   2019.4

Initial Characterization of the Epstein-Barr Virus BSRF1 Gene Product

Yanagi Yusuke, Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

VIRUSES-BASEL   Vol. 11 ( 3 )   2019.3

Defective Epstein-Barr virus (EBV) in chronic active EBV infection and EBV-related hematological malignancy International coauthorship

Okuno Y, Murata Y, Sato Y, Muramatsu H, YIto Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta1 A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.

Nat Microbiol   Vol. 4 ( 3 ) page： 544 - 544   2019.3

EBV Viral Loads in Diagnosis, Monitoring, and Response Assessment

Kimura Hiroshi, Kwong Yok-Lam

FRONTIERS IN ONCOLOGY   Vol. 9 ( FEB ) page： 62   2019.2

Overview of EBV-Associated T/NK-Cell Lymphoproliferative Diseases

Kimura Hiroshi, Fujiwara Shigeyoshi

FRONTIERS IN PEDIATRICS   Vol. 6   2019.1

Clinical features of adult-onset chronic active Epstein-Barr virus infection

KAWAMOTO Keisuke, MIYOSHI Hiroaki, SETO Masao, KIMURA Hiroshi, OHSHIMA Koichi

Rinsho Ketsueki   Vol. 60 ( 8 ) page： 944 - 952   2019

EBV and Lymphomagenesis

KIMURA Hiroshi, OKUNO Yusuke

Uirusu   Vol. 69 ( 1 ) page： 13 - 22   2019

JAK inhibitors for refractory lymphoma.

Kimura H

Oncotarget   Vol. 9 ( 68 ) page： 32883 - 32884   2018.8

Antitumor effects of duvelisib on Epstein-Barr virus-associated lymphoma cells Reviewed

Kawada Jun-ichi, Ando Shotaro, Torii Yuka, Watanabe Takahiro, Sato Yoshitaka, Ito Yoshinori, Kimura Hiroshi

CANCER MEDICINE   Vol. 7 ( 4 ) page： 1275-1284   2018.4

Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells

Ichikawa Takaya, Okuno Yusuke, Sato Yoshitaka, Goshima Fumi, Yoshiyama Hironori, Kanda Teru, Kimura Hiroshi, Murata Takayuki

MSPHERE   Vol. 3 ( 6 )   2018

BGLF2 Increases Infectivity of Epstein-Barr Virus by Activating AP-1 upon De Novo Infection Reviewed

Konishi Natsuno, Narita Yohei, Hijioka Fumiya, Al Masud H. M. Abdullah, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

MSPHERE   Vol. 3 ( 2 )   2018

EBV in T-/NK-Cell Tumorigenesis.

Kimura H

Advances in experimental medicine and biology   Vol. 1045   page： 459-475   2018

Human Herpesviruses Preface

Kimura Hiroshi

HUMAN HERPESVIRUSES   Vol. 1045   page： V - V   2018

Chronic Active Epstein-Barr Virus Disease

Kimura Hiroshi, Cohen Jeffrey I.

FRONTIERS IN IMMUNOLOGY   Vol. 8   page： 1867   2017.12

A distinct subtype of Epstein Barr virus positive T/NK-cell lymphoproliferative disorder: Adult patients with chronic active Epstein Barr virus infection-like features. Reviewed

Kawamoto K, Miyoshi H, Suzuki T, Kozai Y, Kato K, Miyahara M, Yujiri T, Oishi N, Choi I, Fujimaki K, Muta T, Kume M, Moriguchi S, Tamura S, Kato T, Tagawa H, Makiyama J, Kanisawa Y, Sasaki Y, Kurita D, Yamada K, Shimono J, Sone H, Takizawa J, Seto M, Kimura H, Ohshima K

Haematologica     2017.12

Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production

Al Masud H. M. Abdullah, Watanabe Takahiro, Yoshida Masahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

JOURNAL OF VIROLOGY   Vol. 91 ( 23 )   2017.12

Characterization of a Suppressive Cis-acting Element in the Epstein-Barr Virus LMP1 Promoter Reviewed

Yoshida Masahiro, Murata Takayuki, Ashio Keiji, Narita Yohei, Watanabe Takahiro, Al Masud H. M. Abdullah, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi

FRONTIERS IN MICROBIOLOGY   Vol. 8   page： 2302   2017.11

Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia. Reviewed

Washio K, Oka T, Abdalkader L, Muraoka M, Shimada A, Oda M, Sato H, Takata K, Kagami Y, Shimizu N, Kato S, Kimura H, Nishizaki K, Yoshino T, Tsukahara H

Leukemia & lymphoma   Vol. 58 ( 11 ) page： 2683-2694   2017.11

The Epstein-Barr Virus BRRF1 Gene is Dispensable for Viral Replication in HEK293 cells and Transformation. Reviewed

Yoshida M, Watanabe T, Narita Y, Sato Y, Goshima F, Kimura H, Murata T.

Sci Rep 7   Vol. 7   page： 6044   2017.7

Elimination of LMP1-expressing cells from a monolayer of gastric cancer AGS cells

Sato Yoshitaka, Ochiai Shingo, Murata Takayuki, Kanda Teru, Goshima Fumi, Kimura Hiroshi

ONCOTARGET   Vol. 8 ( 24 ) page： 39345-39355   2017.6

The C-Terminus of Epstein-Barr Virus BRRF2 Is Required for its Proper Localization and Efficient Virus Production. Reviewed

Watanabe T, Sakaida K, Yoshida M, Masud HMAA, Sato Y, Goshima F, Kimura H, Murata T

Frontiers in microbiology   Vol. 8   page： 125   2017

The efficacy of combination therapy with oncolytic herpes simplex virus HF10 and dacarbazine in a mouse melanoma model. Reviewed

Tanaka R, Goshima F, Esaki S, Sato Y, Murata T, Nishiyama Y, Watanabe D, Kimura H.

Am J Cancer Res   Vol. 7   page： 1693-170   2017

Epstein-Barr virus infection-induced inflammasome activation in human monocytes. Reviewed

Torii Y, Kawada JI, Murata T, Yoshiyama H, Kimura H, Ito Y.

PLoS One   Vol. 12 ( 4 ) page： e0175053   2017

The efficacy of combination therapy with oncolytic herpes simplex virus HF10 and dacarbazine in a mouse melanoma model.

Tanaka R, Goshima F, Esaki S, Sato Y, Murata T, Nishiyama Y, Watanabe D, Kimura H

American journal of cancer research   Vol. 7 ( 8 ) page： 1693 - 1703   2017

HSV-2-related hemophagocytic lymphohistiocytosis in a fingolimod-treated MS patient. Reviewed

Ikumi K, Ando T, Katano H, Katsuno M, Sakai Y, Yoshida M, Saida T, Kimura H, Sobue G.

Neurol Neuroimmunol Neuroinflamm   Vol. 3 ( 4 ) page： e247   2016

Induction of Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 (LMP1) by Transcription Factors Activating Protein 2 (AP-2) and Early B Cell Factor (EBF). Reviewed

Murata T, Noda C, Narita Y, Watanabe T, Yoshida M, Ashio K, Sato Y, Goshima F, Kanda T, Yoshiyama H, Tsurumi T, Kimura H.

J Virol   Vol. 90   page： 3873-89   2016

A case of CAEBV showing features of granulomatosis with polyangiitis. Reviewed

Shimomura M, Morishita H, Meguro T, Seto S, Kimura M, Hamazaki M, Hashimoto A, Sugiyama Y, Kimura H.

Pediatr Int   Vol. 58   page： 639-42   2016

Diagnostic values for the viral load in peripheral blood mononuclear cells of patients with chronic active Epstein-Barr virus disease. Reviewed

Ito Y, Suzuki M, Kawada J, Kimura H.

J Infect Chemother   Vol. 22   page： 268-271   2016

Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Reviewed

Ando S, Kawada JI, Watanabe T, Suzuki M, Sato Y, Torii Y, Asai M, Goshima F, Murata T, Shimizu N, Ito Y, Kimura H.

Oncotarget   Vol. 7   page： 76793-76805   2016

Analysis of circulating human and viral microRNAs in patients with congenital cytomegalovirus infection. Reviewed

Kawano Y, Kawada JI, Kamiya Y, Suzuki M, Torii Y, Kimura H, Ito Y.

J Perinatol   Vol. 36   page： 1101-1105   2016

A case of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with severe cardiac complications. Reviewed

Kawamura Y, Miura H, Matsumoto Y, Uchida H, Kudo K, Hata T, Ito Y, Kimura H, Yoshikawa T.

BMC Pediatrics   Vol. 16   page： 172   2016

Increased T-cell responses to EBV with high viral load in patients with EBV-positive diffuse large B-cell lymphoma. Reviewed

Morishima S, Nakamura S, Yamamoto K, Miyauchi H, Kagami Y, Kinoshita T, Onoda H, Yatabe Y, Ito M, Miyamura K, Nagai H, Moritani S, Sugiura I, Tsushita K, Mihara H, Ohbayashi K, Iba S, Emi N, Okamoto M, Iwata S, Kimura H, Kuzushima K, Morishima Y.

Leukemia & Lymphoma   Vol. 56   page： 1072-8   2015

Epstein-Barr virus Type 2 latently infects T-cells inducing an atypical activation characterized by expression of lymphotactic cytokines. Reviewed

Coleman CB, Wohlford EM, Smith NA, King CA, Ritchie JA, Baresel PC, Kimura H, Rochford R

J Virol   Vol. 89   page： 2301-12   2015

Viral load in children with congenital cytomegalovirus infection identified on newborn hearing screening. Reviewed

Kawada J, Torii Y, Kawano Y, Suzuki M, Kamiya Y, Kotani T, Kikkawa F, Kimura H, Ito Y.

J Clin Virol   Vol. 65   page： 41-5   2015

Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Reviewed

Kawano Y, Suzuki M, Kawada JI, Kimura H, Kamei H, Ohnishi Y, Ono Y, Uchida H, Ogura Y, Ito Y.

Vaccine   Vol. 33   page： 1440-5   2015

The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas. Reviewed

Suzuki M, Takeda T, Nakagawa H, Iwata S, Watanabe T, Siddiquey MN, Goshima F, Murata T, Kawada JI, Ito Y, Kojima S, Kimura H.

Front Microbiol   Vol. 6   page： 280   2015

Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBVinfected B lymphocytes with TRAbs on their surface. Reviewed

Nagata K, Nakayama Y, Higaki K, Ochi M, Kanai K, Matsushita M, Kuwamoto S, Kato M, Murakami I, Iwasaki T, Nanba E, Kimura H, Hayashi K.

Autoimmunity   Vol. 11   page： 1-8   2015

Roles of Epstein-Barr virus BGLF3.5 Gene and Two Upstream Open Reading Frames in Lytic Viral Replication in HEK293 Cells. Reviewed

Watanabe T, Fuse K, Takano T, Narita Y, Goshima F, Kimura H, Murata T.

Virology   Vol. 483   page： 44–53   2015

The Epstein-Barr virus BRRF2 gene product is involved in viral progeny production. Reviewed

Watanabe T, Tsuruoka M, Narita Y, Katsuya R, Goshima F, Kimura H, Murata T.

Virology   Vol. 484   page： 33-40   2015

A herpesvirus specific motif of Epstein-Barr virus DNA polymerase is required for the efficient lytic genome synthesis. Reviewed

Narita Y, Sugimoto A, Kawashima D, Watanabe T, Kanda T, Kimura H, Tsurumi T, Murata T.

Sci Rep   Vol. 5   page： 11767   2015

Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes. Reviewed

Watanabe T, Narita Y, Yoshida M, Sato Y, Goshima F, Kimura H, Murata T.

J Virol   Vol. 89 ( 19 ) page： 10120-4   2015

Current Studies on Chronic Active Epstein-Barr virus Infection in Japan. Invited

Fujiwara S, Kimura H, Imadome KI, Arai A, Kodama E, Morio T, Shimizu N, Wakiguchi H.

Pediatr Int   Vol. 56   page： 159-166   2014

mTOR inhibitors induce cell cycle arrest and inhibit tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Reviewed

Kawada JI, Ito Y, Iwata S, Suzuki M, Kawano Y, Kanazawa T, Siddiquey MN, Kimura H.

Clin Cancer Res   Vol. 20   page： 5412-22   2014

Anti-CCR4 monoclonal antibody mogamulizumab for the treatment of EBV-associated T- and NK-cell lymphoproliferative diseases. Reviewed

Kanazawa T, Hiramatsu Y, Iwata S, Siddiquey MN, Sato Y, Suzuki M, Ito Y, Goshima F, Murata T, Kimura H.

Clin Cancer Res   Vol. 20   page： 5075-84   2014

Role of latent membrane protein 1 (LMP1) in chronic active Epstein-Barr virus infection (CAEBV)-derived T/NK cell proliferation. Reviewed

Ito T, Kawazu H, Murata T, Iwata S, Arakawa S, Sato Y, Kuzushima K, Goshima F, Kimura H.

Cancer Med   Vol. 3   page： 787-95   2014

Anti-tumor effects of suberoylanilide hydroxamic acid on Epstein-Barr virus-associated T- and natural killer- cell lymphoma. Reviewed

Siddiquey MN, Nakagawa H, Iwata S, Kanazawa T, Suzuki M, Imadome KI, Fujiwara S, Goshima F, Murata T, Kimura H.

Cancer Sci   Vol. 105   page： 713-722   2014

Presence of Epstein-Barr virus-infected B lymphocytes with thyrotropin receptor antibodies on their surface in Graves' disease patients and in healthy individuals. Reviewed

Nagata K, Higaki K, Nakayama Y, Miyauchi H, Kiritani Y, Kanai K, Matsushita M, Iwasaki T, Sugihara H, Kuwamoto S, Kato M, Murakami I, Nanba E, Kimura H, Hayashi K.

Autoimmunity   Vol. 47   page： 193-200   2014

Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant, and granulocyte-macrophage colony-stimulating factor for murine ovarian cancer. Reviewed

Goshima F, Esaki S, Luo C, Kamakura M, Kimura H, Nishiyama Y.

Int J Cancer   Vol. 134   page： 2865-77   2014

Rare occurrence of JAK3 mutations in NK cell neoplasms in Japan. Reviewed

Kimura H, Karube K, Ito Y, Hirano K, Suzuki M, Iwata S, Seto M.

Leukemia & Lymphoma   Vol. 55   page： 962-3   2014

Modes of infection and oncogenesis by the Epstein-Barr virus. Reviewed

Murata T, Sato Y, Kimura H.

Rev Med Virol   Vol. 24   page： 242-253   2014

Remission of juvenile idiopathic arthritis with primary Epstein-Barr virus infection. Reviewed

Kawada J, Ito Y, Torii Y, Kimura H, Iwata N

Rheumatol   Vol. 52   page： 956-8   2013

Epstein-Barr virus-associated lymphoid malignancies: the expanding spectrum of hematopoietic neoplasms. Invited

Kimura H, Kawada J, Ito Y.

Nagoya J Med Sci   Vol. 75   page： 169-79   2013

A pediatric case of hepatitis B virus subgenotype A2 in Japan. Reviewed

Hayashi K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Ito Y, Kimura H, Katano Y, Goto H.

Clin J Gastroenterol   Vol. 6   page： 383-5   2013

A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. Reviewed

Sugimoto KJ, Shimada A, Wakabayashi M, Imai H, Sekiguchi Y, Nakamura N, Sawada T, Ota Y, Takeuchi K, Ito Y, Kimura H, Komatsu N, Noguchi M.

Int J Clin Exp Pathol   Vol. 15   page： 411-7   2013

Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: a case report. Reviewed

Kato S, Miyata T, Takata K, Shimada S, Ito Y, Tomita A, Elsayed AA, Takahashi E, Asano N, Kinoshita T, Kimura H, Nakamura S.

Hum Pathol   Vol. 44   page： 2849-52   2013

HLA-A*26 and HLA-B*52 are associated with a risk of developing EBV-associated T/NK lymphoproliferative disease. Reviewed

Ito Y, Suzuki R, Torii Y, Kawa K, Kikuta A, Kojima S, Kimura H.

Blood e-Letter     page： 8085   2013

Immunogenicity of inactivated seasonal influenza vaccine in adult and pediatric liver transplant recipients over two seasons. Reviewed

Suzuki M, Torii Y, Kawada J, Kimura H, Kamei H, Onishi Y, Kaneko K, Ando H, Kiuchi T, Ito Y.

Microbiol Immunol   Vol. 57   page： 715-22   2013

Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan. Reviewed

Ito Y, Kimura H, Torii Y, Hayakawa M, Tanaka T, Tajiri H, Yoto Y, Tanaka-Taya K, Kanegane H, Nariai A, Sakata H, Tsutsumi H, Oda M, Yokota S, Morishima T, Moriuchi H.

Pediatr Int   Vol. 55   page： 566-571   2013

Heat shock protein 90 inhibitors repress latent membrane protein 1 (LMP1) expression and proliferation of Epstein-Barr virus-positive natural killer cell lymphoma. Reviewed

Murata T, Iwata S, Siddiquey NA, Kanazawa T, Goshima F, Kimura H, Tsurumi T.

PLoS One   Vol. 8   page： e63566   2013

Different Distributions of Epstein-Barr virus early and late gene transcripts within viral replication compartments. Reviewed

Sugimoto A, Sato Y, Kanda T, Murata T, Narita Y, Kawashima D, Kimura H, Tsurumi T.

J Virol   Vol. 87   page： 6693-9   2013

Plasma viral MicroRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection. Reviewed

Kawano Y, Iwata S, Kawada J, Gotoh K, Suzuki M, Torii Y, Kojima S, Kimura H, Ito Y.

J Infect Dis   Vol. 208   page： 771-9   2013

Clinico-epidemiological states of mother-to-child infections: a nationwide survey in Japan. Reviewed

Torii Y, Kimura H, Ito Y, Hayakawa M, Tanaka T, Tajiri H, Yoto Y, Tanaka-Taya K, Kanegane H, Nariai A, Sakata H, Tsutsumi H, Oda M, Yokota S, Morishima T, Moriuchi H.

Pediatr Infect Dis J   Vol. 32   page： 699-701   2013

Interleukin-17A-producing T lymphocytes in chronic active Epstein-Barr virus infection. Reviewed

Ohta R, Imai M, Kawada J, Kimura H, Ito Y.

Microbiol Immunol   Vol. 57   page： 139-44   2013

A monoclonal expansion of Epstein-Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation. Reviewed

Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N.

J Clin Virol   Vol. 56   page： 150-2   2013

Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication. Reviewed

Narita Y, Murata T, Ryo A, Kawashima D, Sugimoto A, Kanda T, Kimura H, Tsurumi T.

J Virol   Vol. 87   page： 2020-7   2013

Causes of vertical transmission of hepatitis B virus under the at-risk prevention strategy in Japan. Reviewed

Torii Y, Kimura H, Hayashi K, Suzuki M, Kawada J, Kojima S, Katano Y, Goto H, Ito Y.

Microbiol Immunol   Vol. 57   page： 118-21   2013

Enhanced antitumoral activitiy of oncolytic herpes simplex virus with gemcitabine using colorectal tumor models. Reviewed

Esaki S, Goshima F, Kimura H, Murakami S, Nishiyama Y

Int J Cancer   Vol. 132   page： 1592-601   2013

Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus -associated hemophagocytic lymphohistiocytosis. Reviewed

Ito Y, Kawamura Y, Iwata S, Kawada J, Yoshikawa T, Kimura H.

Pediatr Blood Cancer   Vol. 60   page： 326-328   2013

Human herpesvirus 6-associated encephalopathy in a child with Dravet syndrome. Reviewed

Hiraiwa-Sofue A, Ito Y, Ohta R, Kimura H, Okumura A.

Neuropediatrics   Vol. 44   page： 155-8   2013

Prospective Monitoring of Epstein-Barr virus and other Herpesviruses in Patients with Juvenile Idiopathic Arthritis Treated with Methotrexate and Tocilizuma Reviewed

Kawada J, Iwata N, Kitagawa Y, Kimura H, Ito Y

Mod Rheumatol     2012

Hydroa vacciniforme is associated with increased numbers of Epstein-Barr virus-infected γδ T-cells. Reviewed

Hirai Y, Yamamoto T, Kimura H, Ito Y, Tsuji K, Miyake T, Morizane S, Suzuki D, Fujii K, Keiji Iwatsuki K.

J Invest Dermatol   Vol. 132   page： 1401-8   2012

Herpes simplex virus requires PARP activity for efficient replication and induces ERK-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1 Reviewed

Li Z, Yamauchi Y, Kamakura M, Murayama T, Goshima F, Kimura H, Nishiyama Y.

  Vol. 86   page： 492-503   2012

EBV-associated T/NK lymphoproliferative diseases in non-immunocompromised hosts:prospective analysis of 108 cases Reviewed

Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, Naoe T, Esaki S, Kikura A, Sawada A, Kawa K, Ohshima K, Nakamura S.

  Vol. 119   page： 673-86   2012

Antitumor activities of valproic acid on Epstein-Barr virus-associated T and natural killer lymphoma cells. Reviewed

Iwata S, Saito T, Ito Y, Kamakura M, Gotoh K, Kawada J, Nishiyama Y, Kimura H

  Vol. 103   page： 375-8   2012

Pretreatment EBV-DNA copy number is predictive of response and toxicities to SMILE chemotherapy for extranodal NK/T-cell lymphoma, nasal type. Reviewed

Ito Y, Kimura H, Maeda Y, Hashimoto C, Ishida F, Izutsu K, Sueoka E, Isobe Y, Takizawa J, Hasegawa Y, Kobayashi H, Okamura S, Kobayashi H, Yamaguchi M, Suzumiya J, Hyo R, Nakamura S, Kawa K, Oshimi K, Suzuki R.

Clin Cancer Res   Vol. 18   page： 4183-4190   2012

Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T-NK lymphoproliferative diseases. Reviewed

Kawabe S, Ito Y, Gotoh K, Kojima S, Matsumoto K, Kinoshita T, Iwata S, Nishiyama Y, Kimura H.

Cancer Sci   Vol. 103   page： 1481-8   2012

Diabetic mice show an aggravated course of herpes-simplex-virus-induced facial nerve paralysis. Reviewed

Esaki S, Yamano K, Kiguchi J, Katsumi S, Keceli S, Okamoto H, Goshima F, Kimura H, Nishiyama Y, Murakami S.

Otol Neurotol   Vol. 33   page： 1452-7   2012

Perinatal cytomegalovirus-associated bullae in an immunocompetent infant. Arch Dermatol Reviewed

Yasuda K, Sugiura K, Ishikawa R, Kihira M, Negishi Y, Iwayama H, Ito K, Kimura H, Kosugi I, Akiyama M.

Arch Dermatol   Vol. 148   page： 770-2   2012

Immunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2. Reviewed

Luo C, Goshima F, Kamakura M, Mutoh Y, Iwata S, Kimura H, Nishiyama Y.

Front Microbiol   Vol. 3   page： 158   2012

T/NK-cell type chronic active Epstein-Barr virus (EBV) disease in adults: an underlying condition for EBV-associated T/NK-cell lymphoma. Reviewed

Isobe Y, Aritaka N, Setoguchi Y, Ito Y, Kimura H, Hamano Y, Sugimoto K, Komatsu N.

J Clin Pathol   Vol. 65   page： 278-82   2012

Generation and characterization of UL21-null herpes simplex virus type 1 Reviewed

Muto Y, Goshima F, Ushijima Y, Kimura H, Nishiyama Y

Front Microbiol   Vol. 3   page： 394   2012

EBV-associated T and NK cell lymphoproliferative disorders: Consensus report of the 4th Asian Hematopathology Workshop. Reviewed

Ko Y-H, Kim H-J, Oh Y-H, Park G, Lee S-S, Huh J, Kim C-W, Kim I, Ng S-B, Tan S-Y, Chuang S-S, Nakamura N, Yoshino T, Nakamura S, Kimura H, Ohshima K.

J Hematopathol   Vol. 5   page： 319-324   2012

Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury. Reviewed

Esaki S, Kitoh J, Katsumi S, Goshima F, Kimura H, Safwat M, Yamano K, Watanabe N, Nonoguchi N, Nakamura T, Coffin RS, Miyatake S, Nishiyama Y, Murakami S.

Gene Therapy     page： in press   2011

Elevated expression of activation-induced cytidine deaminase in T and NK cells from patients with chronic active Epstein-Barr virus infection. Reviewed

Nakamura M, Iwata S, Kimura H, TokuraY.

Eur J Dermatol   Vol. 21   page： 780-2   2011

Chronological changes in Epstein-Barr virus genome and subsets of peripheral mononuclear cells in a case of HLH. Reviewed

Ukeba-Terashita Y, Saita Y, Ito Y, Kanegane H, Kimura H, Kobayashi I.

Open Journal of Pediatrics     page： in press   2011

Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type: the NK-cell Tumor Study Group (NKTSG) study. Reviewed

Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R.

J Clin Oncol   Vol. 29   page： 4410-4416   2011

Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children. Reviewed

Ito Y, Torii Y, Ohta R, Imai M, Hara S, Kawano Y, Matsubayashi T, Inui A, Yoshikawa T, Nishimura N, Ozaki T, Morishima T, Kimura H.

Cytokine     page： in press   2011

Clinicopathological analysis of the age-related differences in patients with Epstein-Barr virus-associated extranasal NK/T-cell lymphoma with reference to the relationship with aggressive NK cell leukemia and chronic active Epstein-Barr virus infection-associated lymphoproliferative disorder. Reviewed

Takahashi E, Ohshima K, Kimura H, Hara K, Suzuki R, Kawa K, Eimoto T, Nakamura S.

Histopathology   Vol. 59   page： 660-67   2011

Relationship between lower respiratory tract infections caused by respiratory syncytial virus and the subsequent development of asthma in Japanese children. Reviewed

Narita A, Nishimura N, Arakawa Y, Suzuki M, Sakamoto K, Sakamoto M, Hosono H, Yamamoto Y, Kimura H, Ozaki T.

Jap J Infect Dis     page： in press   2011

Herpes simplex virus type 1 UL14 tegument protein regulates intracellular compartmentalization of major tegument protein VP16. Reviewed

Ohta A, Yamauchi Y, Muto Y, Kimura H, Nishiyama Y.

Virology J   Vol. 26   page： 365   2011

Identification of Epstein-Barr virus-infected CD27+ memory B cells in patients after transplantation. Reviewed

Ito Y, Kawabe S, Kojima S, Nakamura F, Nishiyama Y, Kaneko K, Kiuchi K, Ando H, Kimura H.

J Gen Virol   Vol. 192   page： 2590-5   2011

Bortezomib Induces Apoptosis in T Lymphoma Cells and Natural Killer Lymphoma Cells Independent of Epstein-Barr Virus Infection. Reviewed

Iwata S, Yano S, Ito Y, Ushijima Y, Gotoh K, Kawada J, Fujiwara S, Sugimoto K, Isobe Y, Nishiyama Y, Kimura H.

Int J Cancer   Vol. 129   page： 2263-2273   2011

Replication of Epstein-Barr virus primary infection in human tonsil tissue explants Reviewed

Gotoh K, Ito Y, Maruo S, Takada K, Mizuno T, Teranishi M, Nakata S, Nakashima T, Iwata S, Goshima F, Nakamura S, Kimura H

PLoS One   Vol. 6   page： e25490   2011

Kinetics of Epstein-Barr Virus Load and Virus-Specific CD8+ T Cells in Acute Infectious Mononucleosis. Reviewed

Hoshino Y, Nishikawa K, Ito Y, Kuzushima K, Kimura H.

J Clin Virol   Vol. 50   page： 244-246   2011

Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients. Reviewed

Torii Y, Kimura H, Gotoh K, Ochi N, Kaneko K, Ando H, Kiuchi T, Ito Y.

Vaccine   Vol. 29   page： 4187-4189   2011

Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza. Reviewed

Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y.

Microbiol Immunol   Vol. 55   page： 191-198   2011

Unrelated bone marrow transplantation induced long-term remission in a patient with life-threatening epstein-barr virus-associated hemophagocytic lymphohistiocytosis. Reviewed

Kunitomi A, Kimura H, Ito Y, Naitoh K, Noda N, Iida H, Sao H.

J Clin Exp Hematop   Vol. 51   page： 57-61   2011

Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0. Reviewed

Kamakura M, Goshima F, Luo C, Kimura H, Nishiyama Y.

Virology J   Vol. 8   page： 257   2011

Auditory and Vestibular Defects Induced by Experimental Labyrinthitis Following Herpes Simplex Virus in Mice. Reviewed

Esaki S, Goshima F, Kimura H, Ikeda S, Katsumi S, Kabaya K, Watanabe M, Hashiba M, Nishiyama Y, Murakami S.

Acta Oto-Laryngologica   Vol. 131   page： 684-691   2011

Quantitative Analysis of Epstein-Barr Virus (EBV)-Related Gene Expression in Patients with Chronic Active EBV infection. Invited Reviewed

Iwata, S., Wada, K., Tobita, S., Gotoh, K., Ito, Y., Demachi-Okamura, A., Shimizu, N., Nishiyama, Y. and Kimura, H.

J Gen Virol   Vol. 90   page： 42-50   2010

Transmission of cytomegalovirus via breast milk in extremely premature infants. Invited Reviewed

Hayashi S, Kimura H, Oshiro M, Kato Y, Yasuda A, Suzuki C, Watanabe Y, Morishima T, Hayakawa M.

J Perinatol     page： in press   2010

Effectiveness and safety of inactivated influenza vaccination in pediatric liver transplant recipients over three influenza seasons. Invited Reviewed

Gotoh K, Ito Y, Suzuki E, Kaneko K, Kiuchi T, Ando H, Kimura H.

Pediatr Transplant     page： in press   2010

Detection of EBV genomes in plasmablasts/plasma cells and non-B cells in the blood of most patients with EBV lymphoproliferative disorders using Immuno-FISH. Invited Reviewed

Calatini S, Sereti I, Scheinberg P, Kimura H, Childs R, Cohen JI.

Blood     page： in press   2010

Multicenter evaluation of prototype real-time PCR assays for Epstein-Barr virus and cytomegalovirus DNA in whole blood samples from transplant recipients" in its current form for publication in Microbiology and Immunology. Invited Reviewed

Ito Y, Takakura S, Ichiyama S, Ueda M, Ando Y, Matsuda K, Hidaka E, Nakatani A, ishioka J, Nobori T, Sasaki M, Kimura H.

Microbiol Immunol   Vol. 54   page： 516-522   2010

Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch. Invited Reviewed

Ushijima Y, Luo C, Kamakura M, Goshima F, Kimura H, Nishiyama Y.

Virology J   Vol. 7   page： 179   2010

Comparison of the cerebrospinal fluid levels and serum concentrations of human herpesvirus 6 (HHV-6) DNA and cytokines in children with HHV-6 encephalopathy. Invited Reviewed

Kawabe S, Ito Y, Ohta R, Sofue A, Gotoh K, Morishima T, Kimura H.

J Med Virol   Vol. 82   page： 1410-1415   2010

Immunologic and Virologic Analyses in Pediatric Liver Transplant Recipients with Chronic High Epstein-Barr Viral Loads Reviewed

Gotoh K, Ito Y, Ohta R, Iwata S, Nishiyama Y, Nakamura T, Kaneko K, Kiuchi T, Ando H, Kimura H.

J Infect Dis   Vol. 202   page： 461-469   2010

Multiplex Real-time PCR Assay for Quantifying BK Polyomavirus, JC Polyomavirus, and Adenovirus DNA Simultaneously Reviewed

Funahashi Y, Iwata S, Ito Y, Kojima, Yoshikawa T, Hattor R, Gotoh M, Nishiyama Y, Kimura H.

J Clin Microbiol   Vol. 48   page： 825-830   2010

Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7. Invited Reviewed

Wada K, Mizoguchi S, Ito Y, Kawada J, Yamauchi Y, Morishima T, Nishiyama Y, Kimura H.

Microbiol Immunol   Vol. 53 ( 1 ) page： 22-29   2009

Epstein-Barr virus Associated Lymphoproliferative Disease in Non-Immunocompromised Hosts. Reviewed

Cohen JI, Kimura H, Nakamura S, Ko Y-H, Jaffe ES.

Ann Oncol   Vol. 20   page： 1472-82   2009

Hepatocellular apoptosis associated with cytotoxic T/naturalkiller-cell infiltration in chronic active EBV infection. Reviewed

Nomura Y, Kimura H, Karube K, Yoshida S, Sugita Y, Niino D, Shimizu K, Kimura Y, Aoki R, Kiyasu J, Takeuchi M, Hashikawa K, Hirose S, Ohshima K.

Pathol Int   Vol. 59   page： 438–442   2009

Cytomegalovirus and Epstein–Barr virus coinfection in three toddlers with prolonged illness. Reviewed

Ito Y, Shibata-Watanabe Y, Kawada J, Maruyama K, Yagasaki H, Kojima S, Kimura H.

J Med Virol   Vol. 81   page： 1399-1402   2009

Acute retinal necrosis caused by herpes simplex virus type 2 in a 3- year-old Japanese boy. Reviewed

Tanaka-Kitajima N, Iwata N, Ando Y, Sakurai H, Iwami M, Tsuzuki K, Kondo M, Ito Y, Kimura H.

Eur J Pediatr   Vol. 168   page： 1125-28   2009

UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions Reviewed

Ushijima Y, Goshima F, Kimura H, Nishiyama Y.

Virology J   Vol. 6   page： 168   2009

*Identification of Epstein-Barr Virus (EBV)-Infected Lymphocyte Subtypes by Flow Cytometric In Situ Hybridization in EBV-Associated Lymphoproliferative Diseases. Reviewed

Kimura H, Miyake K, Yamauchi Y, Nishiyama K, Iwata S, Iwatsuki K, Gotoh K, Kojima S, Ito Y, Nishiyama Y.

J Infect Dis   Vol. 200 ( 7 ) page： 1078-1087   2009

Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss. Invited Reviewed

Mizuno T, Sugiura S, Kimura H, Ando Y, Sone M, Nishiyama Y, Nakashima T.

Eur Arch Otorhinolaryngol.   Vol. 266 ( 3 ) page： 351-355   2009

Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease. Reviewed

Kimura H, Ito Y, Suzuki R, Nishiyama Y.

Rev Med Virol   Vol. 18   page： 305-319   2008

Conversion From Mycophenolate Mofetil to Mizoribine for Patients With Positive Polyomavirus Type BK in Urine. Reviewed

Funahashi Y, Hattori R, Kinukawa T, Kimura H, Nishiyama Y, Gotoh M.

Transplant Proc   Vol. 40   page： 2268-2270   2008

Simultaneous monitoring by real-time PCR of Epstein-Barr virus, human cytomegalovirus, and human herpesvirus 6 in juvenile and adult liver transplant recipients. Reviewed

OnoY, Ito Y, Kaneko K, Shibata-Watanabe Y, Tainaka T, Sumida W, Nakamura T, Kamei H, Kiuchi T, Ando H, Kimura H.

Transplant Proc   Vol. 40   page： 3578-82   2008

Prognostic Factors in Influenza-Associated Encephalopathyモ Reviewed

Nagao T, Morishima T, Kimura H, Yokota S, Yamashita N, Ichiyama T, Kurihara M, Miyazaki C, Okabe N.

Pediat Infect Dis J   Vol. 27   page： 384-389   2008

One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein-Barr virus infection. Reviewed

Kubota, N., Wada, K., Ito, Y., Shimoyama, Y., Nakamura, S., Nishiyama, Y., and Kimura, H.

Journal of Virological Methods   Vol. 147   page： 26-36   2008

The UL14 Tegument Protein of Herpes Simplex Virus Type 1 (HSV-1) is Required for Efficient Nuclear Transport of the Alpha Transinducing Factor VP16 and Viral Capsids. Reviewed

Yamauchi Y, Kiriyama K, Kubota N, Kimura H, Usukura J, Nishiyama Y.

Journal of Virology   Vol. 82   page： 1094-1106   2008

Clinical and virologic characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation Reviewed

Gotoh K, Ito Y, Shibata-Watanabe Y, Kawada J, Takahashi Y, Yagasaki H, Kojima S, Nishiyama Y, Kimura H.

Clinical Infectious Disease   Vol. 46   page： 1525-1534   2008

Oligonucleotide Microarray Analysis of Gene Expression Profiles followed by a Real-time RT-PCR Assay in Chronic Active Epstein-Barr Virus Infection. Reviewed

Ito Y, Shibata-Watanabe Y, Ushijima Y, Kawada J, Nishiyama Y, Kojima S, Kimura H.

Journal of Infectious Disease   Vol. 197   page： 663-666   2008

Measles Outbreak in Adolescent. Invited

Kimura, H. and Nishiyama, Y.

JMA Journal     page： in press   2008

Herpes Simplex Virus Type 2 UL56 Interacts with the Ubiquitin Ligase Nedd4 and Increases its Ubiquitination. Reviewed

Ushijima Y, Koshizuka T, Goshima F, Kimura H, Nishiyama Y.

J Virol   Vol. 82   page： 5220-5233   2008

Herpes Simplex Virus Induces Extensive Modification and Dynamic Relocalisation of the Nuclear Mitotic Apparatus Protein (NuMA) in Interphase Cells Reviewed

Yamauchi, Y., Kiriyama, K., Kimura, H. and Nishiyama, Y.

Journal of Cell Science   Vol. 121   page： 2087-2096   2008

Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss. Reviewed

Mizuno T, Sugiura S, Kimura H, Ando Y, Sone M, Nishiyama Y, Nakashima T.

Eur Arch Otorhinolaryngol     page： in press   2008

Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following gancyclovir treatment. Reviewed

Luo C, Mori I, Ushijima Y, Nawa A, Kimura H, Nishiyama Y.

J Gene Med   Vol. 9   page： 875-883   2007

Association of transforming growth factor-b1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases. Reviewed

Hatta K, Morimoto A, Ishii E, Kimura H, Ueda I, Hibi S, Todo S, Sugimoto T, Imashuku S.

Haematologica   Vol. 92   page： 1470-1474   2007

Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. Reviewed

Tohyama M, Hashimoto K, Yasukawa M, Kimura H, Horikawa T, Nakajima K, Urano Y, Matsumoto K, Iijima M, Shear NH.

Br J Dermatol   Vol. 157   page： 934-940   2007

Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Reviewed

Ushijima Y, Luo C, Goshima F, Yamauchi Y, Kimura H, Nishiyama Y.

Microbes and Infection   Vol. 9   page： 142-149   2007

Simultaneous quantification of Epstein-Barr virus, Cytomegalovirus, and human Herpesvirus 6 DNA in transplant recipients by multiplex real-time PCR assay. Reviewed

Wada, K., Kubota, N., Ito, Y., Yagasaki, H., Kato, K., Yoshikawa, T., Ono, Y., Ando, H., Fujimoto, Y., Kiuchi, T., Kojima, S., Nishiyama, Y. and Kimura H.

Journal of Clinical Microbiology   Vol. 45   page： 1426-1432   2007

Analysis of Gene Expression Profiles byOligonucleotide Microarray in Children with Influenza. Reviewed

Kawada J,Kimura H , Kamachi Y, Nishikawa K, Taniguchi M, Nagaoka K, Kurahashi H, Kojima S, Morishima T.

J Gen Virol   Vol. 87   page： 1677-1683   2006

Fatal Varicella Infection in a Girl with Systemic Lupus Erythematosus after Oral Acyclovir Prophylaxis. Reviewed

Hirose I, Ymamaguchi H, Inagaguma D, Ono K, Shimada S, Kawada J, Shiraki K, Kimura H.

Eur J Pediatr   Vol. 165   page： 280-1   2006

Association of virus infected-T cell in severe hepatitis caused by primary Epstein-Barr virus infection. Reviewed

Hara S, Hoshino Y, Naitou T, Nagano K, Iwai M, Suzuki K, Yamamoto K, Nagasaka T, Morishima T, Kimura H.

J Clinical Virol   Vol. 35   page： 250-256   2006

Chronic Active Epstein-Barr Virus Infection Invited

Kimura H

New Development in Epstein-Barr Virus Research     page： 55-70   2006

Chronic active Epstein-Barr virus infection with dilatation of the Valsalva sinus. Reviewed

Sato Y, Tsuboi T, Mikami T, Kurosawa H, Kanou K, Sugita K, Kimura H , Nagasaka T, Imashyuku S, Eguchi M.

Pediatr Int   Vol. 48   page： 643-645   2006

Rapid detection of Epstein-Barr virus DNA by loop-mediated isothermal amplification method. Reviewed

Iwata S, Shibata Y , Kawada J, Hara S, Nishiyama Y, Morishima T, Ihira M, Yoshikawa T, Asano Y, Kimura H .

J Clin Virol   Vol. 37   page： 128-133   2006

Pathogenesis of chronic active Epstein-Barr virus infection: Is this an infectious disease, lymphoproliferative disorder, or immunodeficiency? Reviewed

Kimura H.

Rev Med Virol   Vol. 16   page： 251-261   2006

Quantitative analysis of herpesvirus load in the lymph nodes of patients with histiocytic necrotizing lymphadenitis using a real-time PCR assay. Reviewed

Maeda N et al,

Diagnostic Molecular Pathology   Vol. 15   page： 49-55   2006

Clonality Analysis by Sequence Variation of the Latent Membrane Protein 1 Gene in Patients with Chronic Active Epstein ?Barr Virus Infection. Reviewed

Shibata Y,Hoshino Y, Hara S, Yagasaki H, Kojima S, Nishiyama Y, Morishima M, Kimura H .

J Med Virol   Vol. 78   page： 770-779   2006

Evaluation of Apoptosis in Epstein-Barr Virus-Associated Haemophagocytic Lymphohistiocytosis. Reviewed

Kawada J, Kimura H , Shibata Y, Hara S, Hoshino Y, Kojima S, Nishikawa K, Morishima T.

J Mel Virol   Vol. 17 ( 78 ) page： 400-407   2006

*Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection. Reviewed

Kimura H, Hoshino Y, Hara S, Sugaya N, Kawada J, Shibata Y, Kojima S, Nagasaka T, Kuzushima K, Morishima T.

J Infect Dis   Vol. 191   page： 531-539   2005

Virological aspects of Epstein-Barr virus infections. Reviewed

Yamashita N, Kimura H, Morishima T.

Acta Med Okayama.   Vol. 59   page： 239-46   2005

Proposed guidelines for diagnosing chronic active epstein-barr virus infection Reviewed

Okano M, Kawa K, Kimura H, Yachie A, Wakiguchi H, Ohga S, Maeda M, Kanegane H, Imai S, Tsuchiya S, Morio T, Mori M, Yokota S, Imashuku S.

Am J Hematol   Vol. 80   page： 64-9   2005

Drug-Induced Hypersensitivity Syndrome due to Mexiletine Associated with Human Herpes Virus 6 and Cytomegalovirus Reactivation. Reviewed

Sekiguchi A, Kashiwagi T, Ishida-Yamamoto A, Takahahi H, Hashimoto Y, Kimura H, Tohyama M, Hashimoto K, Iizuka H.

J Dermatol   Vol. 32   page： 278-281   2005

Congenital Cytomegalovirus Infection Diagnosed by Polymerase Chain Reaction With the Use of Preserved Umbilical Cord. Reviewed

Kakizawa H, Okumura A, Suzuki Y, Natsume J, Kimura H, Negoro T, Watanabe K.

Pediatr Infect Dis J   Vol. 24   page： 653-654   2005

Herpes simplex virus type 1 UL51 protein is involved in maturation and egress of virus particles. Reviewed

Nozawa N, Kawaguchi Y, Tanaka M, Kato A, Kimura H, Nishiyama Y.

J Virol   Vol. 79   page： 6947-6956   2005

Association of cytomegalovirus with infantile hepatitis. Reviewed

Shibata Y, Kitajima N, Kawada J, Sugaya N, Nishikawa K, T Morishima T, Kimura H.

Microbiol Immunol   Vol. 49   page： 771-777   2005

Fatal natural killer cell lymphoma arising in a patient with a crop of Epstein-Barr virus-associated disorders. Reviewed

Nitta Y, Iwatsuki K, Kimura H, Kojima S, Morishima T, Tsuji K, Oono T.

Eur J Dermatol   Vol. 15   page： 503-506   2005

Ganciclovir therapy in congenital cytomegalovirus infection in six infants. Reviewed

Tanaka-Kitajima N, Sugaya N, Futatani T, Kanegane H, Suzuki C, Oshiro M, Hayakawa M, Futamura M, Morishima T, Kimura H.

Pediatr Infect Dis J   Vol. 24   page： 782-785   2005

Rapid detection of herpes simplex virus DNA in cerebrospinal fluid: comparison between loop-mediated isothermal amplification and real-time PCR. Reviewed

Kimura H, Ihira M, Enomoto Y, Kawada J, Ito Y, Morishima T, Yoshikawa T, Asano Y.

Med Microbiol Immunol   Vol. 194   page： 181-185   2005

Chronic active Epstein-Barr virus infection associated with mutations in Perforin that impair its maturation. Reviewed

Katano H, Ali MA, Patera AC, Catalfamo M, Henkart PA, Jaffe ES, Kimura H, Dale JK, Straus SE, Cohen JI.

Blood   Vol. 103   page： 1244-1252   2004

Pharmacokinetics and Effects of Ribavirin following Intraventricular Administration for Treatment of Subacute Sclerosing Panencephalitis. Reviewed

Hosoya M. Mori S. Tomoda A. Mori K. Sawaishi Y. Kimura H. Shigeta S. Suzuki H.

Antimicrob Agents Ch   Vol. 48   page： 4631-4635   2004

Quantitative analysis of Epstein-Barr virus (EBV)-specific CD8+ T cells in chronic active EBV infection. Reviewed

Sugaya N, Kimura H, Hara S, Hoshino Y, Kojima S, Morishima T, Tsurumi T, Kuzushima K.

J Infect Dis   Vol. 190   page： 985-988   2004

Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection. Reviewed

Kawada J, Kimura H, Ito Y, Ando Y, Tanaka-Kitajima N, Hayakawa M, Nunoi H, Endo F, MD, Morishima T.

J Infect Dis   Vol. 190   page： 494-498   2004

Himiconvulsion-hemiplegia syndrome and primary human herpesvirus 7 infection. Reviewed

Kawada J, Kimura H, Yoshikawa T, Ihira M, Okumura A, Morishima T, Hayakawa F.

Brain Dev   Vol. 6   page： 412-414   2004

Comparison of real-time and nested PCR assays for detection of herpes simplex virus DNA. Reviewed

Kawada J, Kimura H, Ito Y, Hoshino Y, Tanaka-Kitajima N, Ando Y, Futamura M, Morishima T.

Microbiol Immunol   Vol. 48   page： 411-415   2004

Monitoring herpesvirus DNA in three cases of acute retinal necrosis by real-time PCR. Reviewed

Asano S, Yoshikawa T, Kimura H, Enomoto Y, Ohashi M, Terasaki H, Nishiyama Y.

J Clin Virol   Vol. 29   page： 206-209   2004

A case of a long-time survivor with chronic active Epstein-Barr virus infection. Reviewed

3) Takeoka Y, Nakao Y, Ueda M, Koh KR, Aoyama Y, Nakamae H, Yamamura R, Ohta K, Takubo T, Yamane T, Hino M, Tokura Y, Ishihara S, Oshima K, Kimura H, Imashuku S.

Eur J Haematol   Vol. 72   page： 73-76   2004

Influenza Virus and Febrile Convulsions. Reviewed

Kawada J, Kimura H, Morishima T.

J Infect Dis   Vol. 189   page： 564-565   2004

Prognostic factors for chronic active Epstein-Barr virus infection. Reviewed

Kimura H, Morishima T, Kanegane H, Ohga S, Hoshino Y, Maeda A, Imai S, Okano M, Morio T, Yokota S, Tsuchiya S, Yachie A, Imashuku S, Kawa K, Wakiguchi H.

J Infect Dis   Vol. 187   page： 527-533   2003

Absence of Associations between Influenza-Associated Encephalopathy and Human Herpesvirus 6 or Human Herpesvirus 7. Reviewed

Kawada J, Kimura H, Ito Y, Hara S, Kawashima H, Okuno T, Morishima T.

Pediatr Infect Dis J   Vol. 22   page： 115-119   2003

Possibility of preventive treatment for EBV-associated NK cell-lineage proliferative disorders. Reviewed

Ishii M, Yamaguchi N, Oshima S, Ishii T, Mori KL, Kimura H, Morishima T, Kawase I, Saeki Y.

Intern Med   Vol. 3   page： 250-254   2003

Evaluation of cytomegalovirus infections transmitted via breast milk in preterm infants with a real-time polymerase chain reaction assay. Reviewed

Yasuda A, Kimura H, Hayakawa M, Oshiro M, Kato Y, Matsuura O, Suzuki C, Morishima T.

Pediatr   Vol. 111   page： 1333-1336   2003

Epstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disorder simultaneously affecting both B and T cells after allogeneic bone marrow transplantation. Reviewed

Chuhjo T, Yachie A, Kanegane H, Kimura H, Siobara S, Nakao S.

Am J Hematol   Vol. 72   page： 255-258   2003

Varicella Exposure in the neonatal medicine: control measurements by prophylactic acyclovir administration. Reviewed

Hayakawa M, Ohshiro M, Kato Y, Fukami E, yasuda A, Okumura A, Kimura H, Morishima T.

J Hospital Infect   Vol. 54   page： 212-215   2003

Combination therapy with intraventricular interferon-a and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay. Reviewed

Hara S, Kimura H, Hoshino Y, Hayashi N, Negoro T, Okumura A, Kajita Y, Sakuma T, Nakayama T, Hosoya M, Tomoda A, Morishima T.

Brain Dev   Vol. 25   page： 367-369   2003

Trial of Intraventricular Ribavirin Therapy for Subacute Sclerosing Panencephalitis in Japan. Reviewed

Tomoda A, Nomura K, Shiraishi S, Hamada A, Ohmura T, Hosoya M, Miike T, Sawaishi Y, Kimura H, Takashima H, Tohda Y, Mori K, Kato Z, Fukushima A, Nishio H, Nezu A, Nihei K.

Brain Dev   Vol. 25   page： 514-517   2003

Relapse of Neonatal Herpes Simplex Virus Infection. Reviewed

Kimura H, Futamura M, Ito Y, Ando Y, Hara S, Sobajima H, Nishiyama Y, Morishima T.

Arch Dis Child Fetal Neonatal Ed   Vol. 88   page： 483-486   2003

Flow cytometoric analysis of cytomegalovirus-specific cell-mediated immunity in the congenital infection. Reviewed

Hayashi N, Kimura H, Morishima T, Tanaka N, Tsurumi T, Kuzushima K.

J Med Virol   Vol. 71   page： 251-258   2003

Systemic Cytokine Responses in Patients with Influenza-Associated Encephalopathy.

Kawada J, Kimura H, Ito Y, Hara S, Iriyama I, Yoshikawa T, Morishima T.

J Infect Dis   Vol. 188   page： 690-698   2003

Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2. Reviewed

Kimura H, Ito Y, Futamura M, Ando Y, Yabuta Y, Hoshino Y, Nishiyama Y, Morishima T.

J Med Virol   Vol. 67   page： 349-353   2002

Fatal adult case with severe lymphocytopenia associated with reactivation of human herpesvirus 6. Reviewed

Yoshikawa T, Ihira M, Asano Y, Tomitaka A, Suzuki K, Matsunaga K, Kato Y, Hiramitsu S, Nagai T, Tanaka N, Kimura H, Nishiyama Y.

J Med Virol   Vol. 66   page： 82-85   2002

Detection of herpesvirus DNA in the serum of immunocompetent children. Reviewed

Hara S, Kimura H, Hoshino Y, Tanaka N, Nishikawa K, Ihira M, Yoshikawa T, Morishima T.

Microbiol Immunol   Vol. 46   page： 177-180   2002

Helicobacter pylori infection in patients with idiopathic short stature. Reviewed

Takahashi M, Kimura H, Watanabe K.

Pediatrics International   Vol. 44   page： 277-280   2002

Epstein-Barr virus specific T cell cytotoxicity is mediated through the perforin pathway in patients with lymphoproliferative disorders after allogeneic bone marrow transplantation. Reviewed

Yoshimi A, Tsuge I, Namizaki H, Hoshino Y, Kimura H, Takahashi Y, Watanabe N, Kuzushima K, Kojima S.

Br J Heamatol   Vol. 116   page： 710-715   2002

Natural Killer Cell Proliferation and Circulating Cytokines in Patients with Bilateral Basal Ganglia Calcification, Reviewed

Morishima T, Morita M, Kato T, Hoshino Y, Kimura H.

Eur J Neurol   Vol. 9   page： 521-525   2002

Viral Load in Epsten-Barr Virus-Associated Hemophagocytic syndrome, Reviewed

Kimura H, Hoshino Y, Hara S, Nishikawa K, Sako M, Hirayama M, Komada Y, Morishima T.

Microbiol Immunol   Vol. 46   page： 579-582   2002

Expression of tegment protein pp65 of Human cytomegalovirus (CMV) and its application for the analysis of viral-specific cellular immunity in CMV-infected individuals, Reviewed

Tanaka N, Kimura H, Hoshino Y, Nishikawa K, Kojima S, Morishima T.

Arch Virol   Vol. 147 ( 12 ) page： 2405-2417   2002

Monitoring of active HHV-6 infection in bone marrow transplant recipients by real time PCR; comparison to detection of viral DNA in plasma by qualitative PCR. Reviewed

Ihira M, Yoshikawa T, Suzuki K, Ohashi M, Suga S, Horibe K, Tanaka N, Kimura H, Kojima S, Kato K, Matsuyama T, Nishiyama Y, Asano Y.

Microbiol Immunol   Vol. 46   page： 701-705   2002

Decreasing the Epstein-Barr virus load by adjusting the FK506 blood level. Reviewed

Orii T, Ohkohchi N, Satomi S, Hoshino Y, Kimura H.

Transpl Int   Vol. 15   page： 529-534   2002

Diagnostic testing in Epstein-Barr virus infection. Reviewed

Kudo T, Egawa H, Kuzushima K, Kimura H, Morishima T, Ichiyama S.

Clin Chem Lab Med   Vol. 39   page： 789-94   2001

Investigation of Varicella-Zoster Virus DNA in Lymphocyte Subpopulations by Quantitative PCR Assay. Reviewed

Ito Y, Kimura H, Hara S, Kido S, Ozaki T, Nishiyama Y, Morishima T.

Microbiol Immunol   Vol. 45   page： 267-269   2001

Impaired Cytotoxic T Lymphocyte Response to Epstein-Barr Virus-infected NK Cells in Patients with Severe Chronic Active EBV Infection. Reviewed

Tsuge I, Morishima T, Morita M, Kimura H, Kuzushima K, Matsuoka H

J Med Virol   Vol. 64   page： 141-148   2001

Vidarabine Therapy for Severe Chronic Active Epstein-Barr Virus Infection. Reviewed

Kimura H, Morita M, Tsuge I, Hoshino Y, Tanaka N, Ito Y, Morishima T.

Am J Pediatr Hematol Oncol   Vol. 23   page： 294-299   2001

Severe Hepatitis caused by Epstein-Barr Virus without infection of hepatocytes Reviewed

Kimura H, Nagasaka T, Hoshino Y, Hayashi N, Tanaka N, Jing Lan Xu, Kuzushima K, Morishima T.

Human pathology   Vol. 32   page： 757-762   2001

SH2D1A mutations in Japanese males with severe Epstein-barr virus associated illness. Reviewed

Sumazaki R, Kanegane H, Osaki M, Fukushima T, Tsutida M, Matsukura H, Shinozaki K, Kimura H, Matsui A, Miyamwaki T.

Blood.   Vol. 98   page： 1268-1270   2001

*Clinical and Virological Characteristics of Chronic Active Epstein-Barr Virus Infection. Reviewed

Kimura H, Hoshino Y, Kanegane H, Tsuge I, Okamura T, Kawa K, Morishim T.

Blood   Vol. 98   page： 280-286   2001

Prospective Monitoring of the Epstein-Barr virus DNA by a real-time quantitative PCR after allogeneic stem cell transplantation. Reviewed

Hoshino Y, Kimura H, Tanaka N, Tsuge I, Kudo K, Horibe K, Kato K, Matsuyama T, Kikuta A, Kojima S, Morishima T.

Br J Heamatol   Vol. 115   page： 105-111   2001

Efficient identification of HLA A*2402-restricted cytomegalovirus-specific CD8+ T cell epitopes by a computer algorithm and an enzyme-linked immunospot assay.

Kuzushima K, Hayashi H, Kimura H, Tsurumi T.

Blood   Vol. 98   page： 1872-1881   2001

Monitoring of four herpesviruses in unrelated cord blood transplantation. Reviewed

Tanaka N, Kimura H, Hoshino Y, Yoshikawa T, Asano Y, Horibe K, Kojima S, Morishima T.

Bone Marrow Transplant   Vol. 26   page： 1193-1197   2000

Usefulness of quantitative real-time polymerase chain reaction in following up patients with Epstein-Barr virus infection after liver transplantation. Reviewed

Orii T, Ohkohchi N, Kikuchi H, Koyamada N, Chubachi S, Satomi S, Kimura H, Hoshino Y, Morita M.

Clin Transplant   Vol. 14   page： 308-317   2000

Longitudinal Dynamics of Epstein-Barr Virus-Specific Cytotoxic T Lymphocytes during Posttransplant Lymphoproliferative Disorder. Reviewed

Kuzushima K, Kimura H, Hoshino Y, Yoshimi A, Tsuge I, Horibe K, Morishima T, Tsurumi T, Kojima S.

J Infect Dis   Vol. 182   page： 937-940   2000

Real-time quantitative reverse transcription-polymerase chain reaction for the detection of AML1-MTG8 fusion transcripts in t(8;21)-positive acute myelogenous leukemia. Reviewed

Kondo K, Kudo K, Kimura H, Inaba J, Kato K, Kojima S, Matsuyama T, Horibe K.

Leukemia Research   Vol. 24   page： 951-956   2000

Early intervention in post-transplant lymphoproliferative disorders based on epstein-barr viral load. Reviewed

Hoshino Y, Kimura H, Kuzushima K, Tsurumi T, Nemoto K, Kikuta A, Nishiyama Y, Kojima S, Matsuyama T, Morishima T.

Bone Marrow Transplant   Vol. 26   page： 199-201   2000

Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir. Reviewed

Ito Y, Kimura H, Yabuta Y, Ando Y, Murakami T, Shiomi M, Morishima T.

Clin Infect Dis   Vol. 30   page： 185-187   2000

Quantitative analysis of cytomegalovirus load using a real-time PCR assay. Reviewed

Tanaka N, Kimura H, Iida K, Saito Y, Tsuge I, Yoshimi A, Matsuyama T, Morishima T.

J Med Virol   Vol. 60   page： 455-462   2000

Monitoring of Cell-Free Viral DNA in Primary Epstein-Barr virus infection. Reviewed

Kimura H, Nishikawa K, Hoshino Y, Sofue A, Nishiyama Y, and Morishima T.

Med Microbiol Immunol   Vol. 188   page： 197-202   2000

Comparison of quantitations of viral load in varicella and zoster. Reviewed

Kimura H, Kido S, Ozaki T, Tanaka N, Ito Y, Williams RK, Morishima T.

J Clin Microbiol   Vol. 38   page： 2447-2449   2000

Large deletion of the X-linked lymphoproliferative disease gene detected by fluorescence in situ hybridization. Reviewed

Honda K, Kanegane H, Eguchi M, Kimura H, Morishima T, Masaki K, Tosato G, Miyawaki T, Ishii E.

Am J Hematol   Vol. 64   page： 128-132   2000

The prevalence of TT virus (TTV) infection and its relationship to hepatitis in children. Reviewed

Iriyama M, Kimura H, Nishikawa K, Yoshioka K, Wakita T,Nishimura N, Shibata M, Ozaki T, Morishima T

Med Microbiol Immunol   Vol. 188   page： 83-89   1999

*Quantitative analysis of the Epstein-Barr virus load using a real-time PCR assay. Reviewed

J. Clin. Microbiol.   Vol. 37   page： 132-136   1999

Characterization of Epstein-Bar virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy; establishment of an IL-2-dependent NK-like cell line. Reviewed

Tsuge I, Morishima T, Morita M, Kimura H, Kuzushima K, Matsuoka H.

Clin Exp Immunol.   Vol. 115   page： 385-392   1999

CD4- and CD56-positive T-cell line, MTA, established from natural killer-like T-cell leukemia/lymphoma. Reviewed

Emi N, Abe A, Kasai M, Kohno A, Tanimoto M, Kimura H, Kawashima K, Ito M, Mori N, Saito H.

Int J Hematol   Vol. 69   page： 180-185   1999

Detection of influenza virus RNA by reverse transcription-PCR and proinflammatorycytokines in influenza-virus-associated encephalopathy. Reviewed

Ito Y, Ichiyama T, Kimura H, Shibata M, Ishiwada N, Kuroki H, Furukawa S, Morishima T

J Med Virol   Vol. 58   page： 420-425   1999

Prevalence of maternal cytomegalovirus (CMV) antibody and detection of CMV DNA in amniotic fluid. Reviewed

Nishimura N, Kimura H, Yabuta Y, Tanaka N, Ito Y, Ishikawa K, Suzuki C, Morishima T.

Microbiol Immunol   Vol. 43   page： 781-784   1999

Rapid determination of Epstein-Barr virus specific CD8+T cell frequencies by flow cytometry. Reviewed

Kuzushima K, Hoshino Y, Fujii K, Yokoyama N, Fujita M, Kiyono T, Kimura H, Morishima T, Trurumi T.

Blood   Vol. 94   page： 3094-3100   1999

Antigen-driven expansion and contraction of CD8+-activated T cells in primary EBV infection. Reviewed

Hoshino Y, Morishima T, Kimura H, Nishikawa K, Tsurumi T, Kuzushima K.

J Immunol   Vol. 163   page： 5735-5740   1999

Baculovirus expression, purification, and properties of VZV gE, gI, and the complex they form. Reviewed

Kimura H, Straus SE, and Williams RK.

J Infect Dis   Vol. 178   page： 513-515   1998

Recombinant Varicella-Zoster virus glycoprotein E and I : immunologic response and clearance of virus in a guinea pig model of chronic uveitis(共著) Reviewed

Journal of Infectious Deseases   Vol. 178   page： 310   1998

Polymerase chain reaction-proven herpes simplex encephalitis in children. Reviewed

Ito Y, Ando Y, Kimura H, Kuzushima K, Morishima T.

Pediatr Infect Dis J   Vol. 17   page： 29-32   1998

Varicella-zoster virus glycoproteins E and I expressed in insect cells form a heterodimer that requires the N-terminal domain of glycoprotein I. Reviewed

Kimura H, Straus SE, and Williams RK.

Virology.   Vol. 233   page： 382-391   1997

Establishment of anti-Epstein-Barr virus (EBV) cellular immunity by adoptive transfer of virus-specific cytotoxic T lymphocytes from an HLA-matched sibling to a patient with severe chronic active EBV infection. Reviewed

Kuzushima K, Yamamoto M, Kimura H, Ando T, Kudo T, Tsuge I, Morishima T.

Clin Exp Immunol   Vol. 103   page： 192-198   1996

Epstein-Barr virus (EBV)-carrying and -expressing T-cell lines established from severe chronic active EBV infection. Reviewed

Imai S, Sugiura M, Oikawa O, Koizumi S, Hirao M, Kimura H, Hayashibara H, Terai N, Tsutsumi H, Oda T, Chiba s, Osato T.

Blood   Vol. 87   page： 1446-1457   1996

Detection and quantification of virus DNA in plasma of patients with Epstein-Barr virus-associated diseases. Reviewed

Yamamoto M. Kimura H. Hironaka T. Hirai K. Hasegawa S. Kuzushima K. Shibata M. Morishima T.

J Clin Microbiol   Vol. 33   page： 1765-1768   1995

Intact antigen presentation for Epstein-Barr virus (EBV)-specific CTL by a lynphoblastoid cell line established from a patient with severe chronic active EBV intection

Medical Microbiology and Immunology   Vol. 184   page： 63   1995

T-cell receptor V α region usage in the cerebrospinal fluid of patients with mumps meningitis. Reviewed

Kimura H, Ando Y, Shibata M, Abe T and Morishima T.

J Med Virol   Vol. 41   page： 306-311   1993

Quantitative analysis of herpes simplex virus DNA in cerebrospinal fluid of children with herpes simplex encephalitis. Reviewed

Ando Y, Kimura H, Miwata H, Kudo T, Shibata M and Morishima T.

J Med Virol   Vol. 41   page： 170-173   1993

Serum amyloid A protein in acute viral infections. Reviewed

Miwata H, Yamada T, Okada M, Kudo T, Kimura H and Morishima T.

Arch Dis Child   Vol. 68   page： 210-214   1993

Relapse of Herpes simplex encephalitis in children. Reviewed

Kimura H, Aso K, Kuzushima K, Hanada N, Shibata M and Morishima T.

Pediatr   Vol. 89   page： 891-894   1992

Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. Reviewed

Yoshikawa T, Nakashima T, Suga S, Asano Y, Yazaki T, Kimura H, Morishima T, Kondo K and Yamanishi K.

Pediatr   Vol. 89   page： 888-890   1992

Quantitation of cytomegalovirus DNA in lung tissue of bone marrow transplant recipients. Reviewed

Shibata M, Terashima M, Kimura H, Kuzushima K, Yoshida J, Horibe K, Morishima T.

Hum Pathol   Vol. 23   page： 911-915   1992

Prophylactic oral acyclovir in outbreaks of primary herpes simplex virus type 1 Infection in a closed community. Reviewed

Kuzushima K, Kudo T, Kimura H, Kido S, Hanada N, Shibata M, Nishikawa K and Morishima T.

Pediatr   Vol. 89   page： 379-383   1992

Detction of viral DNA in neonatal herpes simplex virus infuctions: Frequent and prolonged presence in serum and cerebrospinal fluid. Reviewed

Kimura H, Futamura M, Kito H, Ando T, Goto M, Kuzushima K, Shibata M, Morishima T.

J Infect Dis   Vol. 164   page： 289-293   1991

Minus strand RNA of hepatitis C virus in liver tissues. Reviewed

Shibata M, Takeda S, Kudo T, Kimura H, Kuzushima K, Morishima T, Nagai Y.

J Hepatol   Vol. 13   page： 379-380   1991

The pathogenecity of ribonucleotide reductase-null mutant of herpes simplex virus type 1 in mice. Reviewed

Yamada Y, Kimura H, Morishima T, Daikoku T, Maeno K, Nishiyama Y.

J Infect Dis   Vol. 164   page： 1091-1097   1991

Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus type 1 and 2. Reviewed

Nishiyama Y, Kimura H, Daikoku T.

J Virol   Vol. 65   page： 4520-4524   1991

Clinical manifestations of primary herpes simplex Virus type I infection in a closed community. Reviewed

Kuzushima K, Kimura H, Kino Y, Kido S, Hanada N, Shibata M, Morishima T.

Pediatr   Vol. 87   page： 152-158   1991

Human cytomegalovirus infection during childhood: Detection of viral DNA in peripheral blood by means of polymerase chain reaction. Reviewed

Shibata M, Morishima T, Terashima T, Kimura H, Kuzushima K, Hanada N, Nishikawa K and Watanabe K.

Med Microbiol Immunol   Vol. 179   page： 245-253   1990

Detection and direct typing of herpes simplex virus by polymerase chain raction. Reviewed

Kimura H, Shibata M, Kuzushima K, Nishiyama Y. Morishima T.

Med Microbiol Immunol   Vol. 179   page： 177-184   1990

SHepatitis C viral sepuences in sera during the acute phase of infection. Reviewed

hibata M, Kudo T, Kajiyama M, Takahashi T, Matsushima S, Kimura H, Kuzushima K, and Morishima T.

Am J Med   Vol. 89   page： 830-832   1990

Prophylactic oral acyclovir in outbreaks of primary herpes simplex virus 1 infection. Reviewed

Kuzushima K, Kimura H, Shibata M, Nishikawa K, Morishima T.

Lancet   Vol. 335   page： 1043   1990

Human Herpesviruses

Kawaguchi Y, Mori Y, Kimura H（ Role： Joint editor）

Springer Nature Singapore Pte Ltd  2018.7  （ ISBN:9789811072291 ）

*EBV-positive T-cell and NK-cell lymphoproliferative diseases of childhood: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Jaffe ES, Harris NL, Stein H, et al., eds

Quintanilla-Martinez L, Ko YH, Kimura H, Jaffe ES.（ Role： Joint author）

IARC Press, Lyon  2017.9  （ ISBN:978-92-832-4494-3 ）

*EBV-positive T-cell lymphoproliferative disorders of childhood: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Jaffe ES, Harris NL, Stein H, et al., eds

Quintanilla-Martinez L, Kimura H, Jaffe ES.（ Role： Joint author）

IARC Press, Lyon  2008 

Chronic Active Epstein-Barr Virus Infection; New Developments in Epstein-Barr Virus Research,

Kimura H（ Role： Joint author）

Nova Science Publishers  2006.9  （ ISBN:1-59454-860-9 ）

From Bedside to Bench, and Back Again Invited

木村　宏

第13回愛知県小児臨床研究会  2021.11.10 

ありふれたウイルスが腫瘍を引き起こす謎の解明 Invited

木村　宏

第41回阿蘇シンポジウム  2021.8.21 

Medical education during COVID-19 International conference

Hiroshi Kimura

4th Digital GAME Annual Meeting  2020.10.15 

大学人として知っておくべきコロナウイルスのこと Invited

木村　宏

第5回 東海機構ポストコロナフォーラム・イン・ウェビナー 

慢性活動性EBウイルス感染症 Invited

木村　宏

第42回日本造血細胞移植学会総会 

Chronic Epstein-Barr virus lymphoproliferative disease Invited International conference

Hiroshi Kimura

12th Annual T-cell Lymphoma Forum  2020.2.1 

母子感染に対する母子保健体制構築と医療技術開発のための研究

2016.4 - 2019.3

成育疾患克服等研究事業 

藤井知行

慢性活動性EBウイルス感染症とその類縁疾患に対する革新的治療薬を実現するための統合的研究体制の構築

2015.4 - 2018.3

難治性疾患実用化研究事業 

伊藤嘉規

慢性活動性EBウイルス感染症とその類縁疾患に対する革新的治療薬を実現するための統合的研究体制の構築

2015.4 - 2018.3

難治性疾患実用化研究事業 

藤原成悦

慢性活動性EBウイルス感染症とその類縁疾患に対する革新的治療薬を実現するための独創的開発基盤

2014.7 - 2015.3

科学技術振興調整費 

慢性活動性EBウイルス感染症とその類縁疾患の診療ガイドライン作成 と患者レジストリの構築

2014.4 - 2017.3

科学技術振興調整費 

母子感染の実態把握及び検査・治療に関する研究

2013.8 - 2016.3

科学技術振興調整費 

慢性活動性EBウイルス感染症の発症機構解明と新規治療法開発に関する研究

2012.4 - 2014.3

科学技術振興調整費 

小児期のウイルス性肝炎に対する治療法の標準化に関する研究

2011.8 - 2013.3

科学技術振興調整費 

多角的解析によるEBV発癌を抑制する新規薬剤開発と ワクチン開発

2010.4 - 2013.3

科学技術振興調整費 

臓器移植患者の予後およびQOLの向上のための真菌やウイルス感染症の予防・診断・治療に関する研究

2009.4 - 2012.3

科学技術振興調整費 

B型肝炎の母子感染および水平感染の把握とワクチン戦略の再構築に関する研究

2009.4 - 2012.3

科学技術振興調整費 

慢性活動性EBV感染症の実態解明と診断法確立に関する研究

2009.4 - 2012.3

科学技術振興調整費 

ＥＢＶ研究用試薬に添付する標準物質の値付けに係る検討

2008.4 - 2009.3

企業からの受託研究 

TaqManPCR法によるCMVおよびEBV測定アプリケーション（研究用）の性能評価試験

2007.6

企業からの受託研究 

NK細胞腫瘍に対する東アジア多国間治療研究

2007.4 - 2010.3

科学技術振興調整費 

インフルエンザ脳症の発症因子の解明とそれに基づく発症前診断方法の確立に関する研究

2006.4 - 2007.3

科学技術振興調整費 

ＥＢＶおよびＣＭＶのTaqManPCR法による研究用製品化の検討

2006.4 - 2007.3

企業からの受託研究 

７価肺炎球菌ワクチン（7vPnCV)第II相臨床試験

2004.9 - 2006.3

企業からの受託研究 

インフルエンザ脳症の発症因子の解明と治療及び予防方法の確立に関する研究

2004.4 - 2006.3

科学技術振興調整費 

BK-VJE追加接種のための臨床試験

2004.4 - 2005.3

企業からの受託研究 

血中チトクロムC測定試薬（EDO070)

2003.10 - 2004.3

企業からの受託研究 

サルモデルにおけるベクターの安全性・有効性の評価実験系の開発

2000.4 - 2001.3

科学技術振興調整費 

インフルエンザ等の呼吸器感染症に関する研究

1998.4 - 1999.3

科学技術振興調整費 

遠隔転移腫瘍に対する腫瘍溶解ウイルスを用いた新規治療法の開発

2016.4 - 2019.3

科学研究費補助金  基盤研究(C)

五島典

造血幹細胞移植患者における生体内ウイルス集団（Virome）の解明

2014.4 - 2016.3

科学研究費補助金 

EBV関連Tリンパ腫発生に関与する宿主遺伝子の同定と機能解析

2013.4 - 2016.3

科学研究費補助金  基盤研究(B)

難治性腫瘍に対するHSV1 型アンプリコンシステムを用いた新規遺伝子治療の開発

2012.4 - 2015.3

科学研究費補助金  基盤研究(C)

難治性ＥＢウイルス感染症に対する免疫寛容を利用した細胞療法の確立

2012.4 - 2014.3

科学研究費補助金 

単純ヘルペスウイルスの増殖を制御する宿主因子の同定とその役割の解明

2010.4 - 2013.3

科学研究費補助金  基盤研究(B)

新規に開発したＥＢＶ感染細胞同定法によるＥＢＶ関連疾患の診断および病態解析

2009.4 - 2012.3

科学研究費補助金  基盤研究(C)

木村　宏

小児における急性脳炎・脳症の病態・診断・治療に関する研究

2008.4 - 2010.3

科学研究費補助金  基盤研究(A)

造血幹細胞・臓器移植後に発生する難治性ウイルス感染症の早期発見・予防法の確立

2007.4 - 2008.3

科学研究費補助金  基盤研究(C)

木村　宏

小児における急性脳炎・脳症の病態・診断・治療に関する研究

2005.4 - 2007.3

科学研究費補助金  基盤研究(A)

岡山大学・森島恒雄

低出生体重児における症候性サイトメガロウイルス感染症の実態調査と予防

2004.4 - 2006.3

科学研究費補助金  基盤研究(C)

木村　宏

造血幹細胞移植後の免疫不全状態における難治性ウイルス感染症における細胞療法の開発

2002.4 - 2003.3

科学研究費補助金  高度先進医療開発経費

免疫不全状態におけるウイルス感染症の再活性化の病態解明と予防・治療

2001.4 - 2003.3

科学研究費補助金  基盤研究(C)

病理病態学

2021

First Year Seminar B

2020

Microorganisms and Human

2020

Training for Medical Research

2020

Molecular Pathology

2020