Updated on 2021/10/22

写真a

 
KIMURA, Hiroshi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor

Degree 1

  1. 医学博士 ( 1993.3   名古屋大学 ) 

Research Interests 1

  1. tumor virus, herpesvirus, control for intractable viral infection, CNS viral infection, cell therapy

Research Areas 2

  1. Others / Others  / Virology

  2. Others / Others  / Pediatrics

Current Research Project and SDGs 3

  1. 免疫不全宿主における日和見感染症の病態診断・制御研究

  2. Study on the pathogenesis of intractable herpesviral diseases and developement of their therapies

  3. ウイルス病原性の分子基盤の解明と宿主因子との相互作用の解析 

Research History 5

  1. 名古屋大学医学部ウイルス学 教授

    2012.8

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    Country:Japan

  2. 名古屋大学医学部ウイルス学、助(准)教授

    2005.8

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    Country:Japan

  3. 名古屋大学医学部小児科、講師

    2001.4 - 2005.7

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    Country:Japan

  4. 名古屋大学医学部小児科、助手

    1998.4 - 2001.3

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    Country:Japan

  5. 名古屋大学医学部小児科、医員

    1997.10 - 1998.3

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    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Medicine

    - 1993

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 1985

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    Country: Japan

Professional Memberships 7

  1. 日本臨床ウイルス学会

  2. 日本小児感染症学会   理事、評議員、研究委員会委員長

  3. 日本小児科学会   専門医

  4. 日本ウイルス学会   理事、評議員

  5. 日本感染症学会   専門医

  6. 日本血液学会

  7. 日本癌学会

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Awards 3

  1. 愛知県難病研究者表彰

    2018.3   愛知県医師会  

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    Country:Japan

  2. 荻村孝特別研究賞受賞

    2013.11   日本白血病研究基金  

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    Country:Japan

  3. 日本小児科学会学術集会 最優秀演題受賞

    2000.8  

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    Country:Japan

 

Papers 253

  1. A STING inhibitor suppresses EBV-induced B cell transformation and lymphomagenesis. Reviewed International coauthorship

    Miyagi S, Watanabe T, Hara Y, Arata M, Uddin MK, Mantoku K, Sago K, Yanagi Y, Suzuki T, Masud HMAA, Kawada JI, Nakamura S, Miyake Y, Sato Y, Murata T, Kimura H

    Cancer science     2021.10

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.15152

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  2. Deletion of Viral microRNAs in the Oncogenesis of Epstein-Barr Virus-Associated Lymphoma Invited Reviewed

    Kimura Hiroshi, Okuno Yusuke, Sato Yoshitaka, Watanabe Takahiro, Murata Takayuki

    FRONTIERS IN MICROBIOLOGY   Vol. 12   page: 667968   2021.7

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Frontiers in Microbiology  

    Epstein–Barr virus (EBV), which encodes >80 genes and nearly 50 non-coding RNAs, is a double-stranded DNA virus. EBV is associated with various types of lymphomas and lymphoproliferative disorders not only of B-cell but also T/NK-cell origin. However, the oncogenic mechanism remains poorly understood, including the EBV receptors expressed on T/NK cells, relationship of EBV with host genes, and epigenetic regulation of EBV and host genes. The roles of host and viral non-coding RNAs during tumorigenesis have been elucidated. EBV encodes at least 49 mature microRNAs (miRNAs), of which 44 are located in BamHI-A rightward transcripts (BARTs) region, and the remaining five are located in BamHI-H rightward fragment 1. BART miRNAs modulate cell differentiation, proliferation, apoptosis, and the cell cycle, and they are considered positive regulators of oncogenesis. We and others have recently reported that EBV-positive lymphomas frequently possess large deletions in BART miRNA clusters, suggesting that some viral miRNAs have suppressive effects on oncogenesis, and that deletion of these miRNAs may aid lymphoma formation.

    DOI: 10.3389/fmicb.2021.667968

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  3. RNAseq analysis identifies involvement of EBNA2 in PD-L1 induction during Epstein-Barr virus infection of primary B cells Reviewed International coauthorship

    Yanagi Y.

    Virology   Vol. 557   page: 44 - 54   2021.5

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Virology  

    DOI: 10.1016/j.virol.2021.02.004

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  4. Role of Epstein-Barr Virus C Promoter Deletion in Diffuse Large B Cell Lymphoma Reviewed International coauthorship

    Mabuchi Seiyo, Hijioka Fumiya, Watanabe Takahiro, Yanagi Yusuke, Okuno Yusuke, Al Masud H. M. Abdullah, Sato Yoshitaka, Murata Takayuki, Kimura Hiroshi

    CANCERS   Vol. 13 ( 3 )   2021.2

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers13030561

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  5. Direct Evidence of Abortive Lytic Infection-Mediated Establishment of Epstein-Barr Virus Latency During B-Cell Infection Reviewed International coauthorship

    Inagaki Tomoki, Sato Yoshitaka, Ito Jumpei, Takaki Mitsuaki, Okuno Yusuke, Yaguchi Masahiro, Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Kei, Iwami Shingo, Murata Takayuki, Kimura Hiroshi

    FRONTIERS IN MICROBIOLOGY   Vol. 11   2021.1

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Frontiers in Microbiology  

    DOI: 10.3389/fmicb.2020.575255

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  6. Chronic active EB virus infection

    Kimura Hiroshi

    Journal of Hematopoietic Cell Transplantation   Vol. 10 ( 2 ) page: 87 - 93   2021

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japan Society for Hematopoietic Stem Cell Transplantation  

    <p> Chronic active EB virus infection is an intractable disease. EBV latently infects T cells or NK cells, proliferates in a clonal manner, infiltrates organs, and triggers various symptoms. The prognosis is generally poor; in the absence of treatment, organ complications and a blast crisis often cause death. Recently, we performed a large-scale, comprehensive genetic analysis of patients with chronic active EB virus infection, and found: 1) it is unlikely that any primary immunodeficiency is in play (because mutations in germ cell sequences were rarely observed); 2) EBV-infected cells contained mutations in driver genes such as DDX3X and KMT2D and, in cases that could be observed over time, clonal evolution of EBV-infected cells was evident; and, 3) defective EBV was frequently observed and may be involved in disease onset. This review outlines the pathology of chronic active EB virus infection revealed by our genetic analyses, and the latest views on optimal diagnosis and treatment.</p>

    DOI: 10.7889/hct-20-026

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  7. Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma. Reviewed

    Takano G, Esaki S, Goshima F, Enomoto A, Hatano Y, Ozaki H, Watanabe T, Sato Y, Kawakita D, Murakami S, Murata T, Nishiyama Y, Iwasaki S, Kimura H.

    Molecular Therapy – Oncolytics   Vol. 20   page: 220 - 227   2020.12

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    DOI: 10.3389/fmicb.2020.575255

  8. Oncolytic activity of HF10 in head and neck squamous cell carcinomas. Reviewed

    Esaki S, Goshima F, Ozaki H, Takano G, Hatano Y, Kawakita D, Ijichi K, Watanabe T, Sato Y, Murata T, Iwata H, Shibamoto Y, Murakami S, Nishiyama Y, Kimura H

    Cancer gene therapy   Vol. 27 ( 7-8 ) page: 585 - 598   2020.8

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    DOI: 10.1038/s41417-019-0129-3

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  9. Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days Reviewed

    Sato Yoshitaka, Iguchi Mitsutaka, Kato Yoshiaki, Morioka Hiroshi, Hirabayashi Aki, Tetsuka Nobuyuki, Tomita Yuka, Kato Daizo, Yamada Kiyofumi, Kimura Hiroshi, Yagi Tetsuya

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page: 407-414   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.82.3.407

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  10. Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification Reviewed

    Yonese Ichiro, Sakashita Chizuko, Imadome Ken-Ichi, Kobayashi Tohru, Yamamoto Masahide, Sawada Akihisa, Ito Yoshinori, Fukuhara Noriko, Hirose Asao, Takeda Yusuke, Makita Masanori, Endo Tomoyuki, Kimura Shun-Ichi, Ishimura Masataka, Miura Osamu, Ohga Shouichi, Kimura Hiroshi, Fujiwara Shigeyoshi, Arai Ayako

    BLOOD ADVANCES   Vol. 4 ( 13 ) page: 2918-2926   2020.7

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    DOI: 10.1182/bloodadvances.2020001451

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  11. A systemic form chronic active Epstein-Barr virus infection diagnosed from erythema nodosum-like skin lesions. Reviewed

    Shibata A, Ishiguro Y, Makita S, Yamaga Y, Kimura H, Akiyama M

    European journal of dermatology : EJD   Vol. 30 ( 3 ) page: 314-316   2020.6

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    DOI: 10.1684/ejd.2020.3781

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  12. Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting Reviewed International coauthorship

    Cohena Jeffrey I., Iwatsuki Keiji, Ko Young-Hyeh, Kimura Hiroshi, Manoli Irini, Ohshima Koichi, Pittaluga Stefania, Quintanilla-Martinez Leticia, Jaffe Elaine S.

    LEUKEMIA & LYMPHOMA   Vol. 61 ( 4 ) page: 808-819   2020.3

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    DOI: 10.1080/10428194.2019.1699080

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  13. Oncogenesis of CAEBV revealed: Intragenic deletions in the viral genome and leaky expression of lytic genes Reviewed

    Murata Takayuki, Okuno Yusuke, Sato Yoshitaka, Watanabe Takahiro, Kimura Hiroshi

    REVIEWS IN MEDICAL VIROLOGY   Vol. 30 ( 2 ) page: e2095   2020.3

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/rmv.2095

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  14. Antitumor activity of CDK inhibitor alsterpaullone in Epstein-Barr virus-associated lymphoproliferative disorders. Reviewed International coauthorship

    Watanabe T, Sato Y, Masud HMAA, Takayama M, Matsuda H, Hara Y, Yanagi Y, Yoshida M, Goshima F, Murata T, Kimura H

    Cancer science     2020.1

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    DOI: 10.1111/cas.14241

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  15. Epstein-Barr Virus BBRF2 Is Required for Maximum Infectivity

    Al Masud H. M. Abdullah, Yanagi Yusuke, Watanabe Takahiro, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

    MICROORGANISMS   Vol. 7 ( 12 )   2019.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/microorganisms7120705

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  16. NK-cell post-transplant lymphoproliferative disease with chronic active Epstein-Barr virus infection-like clinical findings.

    Iemura T, Kondo T, Hishizawa M, Yamashita K, Kimura H, Takaori-Kondo A

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     2019.8

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    DOI: 10.1016/j.ijid.2019.07.039

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  17. Editorial: Epstein-Barr Virus-Associated T/NK-Cell Lymphoproliferative Diseases

    Fujiwara Shigeyoshi, Kimura Hiroshi

    FRONTIERS IN PEDIATRICS   Vol. 7 ( JULY ) page: 285   2019.7

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    DOI: 10.3389/fped.2019.00285

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  18. Viral DNA loads in various blood components of patients with Epstein-Barr virus-positive T/NK cell lymphoproliferative diseases.

    Kawada JI, Kamiya Y, Sawada A, Iwatsuki K, Izutsu K, Torii Y, Kimura H, Ito Y

    The Journal of infectious diseases     2019.6

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    DOI: 10.1093/infdis/jiz315

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  19. The BOLF1 gene is necessary for effective Epstein-Barr viral infectivity

    Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

    VIROLOGY   Vol. 531   page: 114-125   2019.5

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    DOI: 10.1016/j.virol.2019.02.015

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  20. S-Like-Phase Cyclin-Dependent Kinases Stabilize the Epstein-Barr Virus BDLF4 Protein To Temporally Control Late Gene Transcription

    Sato Yoshitaka, Watanabe Takahiro, Suzuki Chihiro, Abe Yuichi, Al Masud H. M. Abdullah, Inagaki Tomoki, Yoshida Masahiro, Suzuki Takeshi, Goshima Fumi, Adachi Jun, Tomonaga Takeshi, Murata Takayuki, Kimura Hiroshi

    JOURNAL OF VIROLOGY   Vol. 93 ( 8 )   2019.4

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    DOI: 10.1128/JVI.01707-18

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  21. Initial Characterization of the Epstein-Barr Virus BSRF1 Gene Product

    Yanagi Yusuke, Al Masud H. M. Abdullah, Watanabe Takahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

    VIRUSES-BASEL   Vol. 11 ( 3 )   2019.3

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    DOI: 10.3390/v11030285

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  22. Defective Epstein-Barr virus in chronic active infection and haematological malignancy

    Okuno Yusuke, Murata Takayuki, Sato Yoshitaka, Muramatsu Hideki, Ito Yoshinori, Watanabe Takahiro, Okuno Tatsuya, Murakami Norihiro, Yoshida Kenichi, Sawada Akihisa, Inoue Masami, Kawa Keisei, Seto Masao, Ohshima Koichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Narita Yohei, Yoshida Masahiro, Goshima Fumi, Kawada Jun-Ichi, Nishida Tetsuya, Kiyoi Hitoshi, Kato Seiichi, Nakamura Shigeo, Morishima Satoko, Yoshikawa Tetsushi, Fujiwara Shigeyoshi, Shimizu Norio, Isobe Yasushi, Noguchi Masaaki, Kikuta Atsushi, Iwatsuki Keiji, Takahashi Yoshiyuki, Kojima Seiji, Ogawa Seishi, Kimura Hiroshi

    NATURE MICROBIOLOGY   Vol. 4 ( 3 ) page: 404 - 413   2019.3

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    DOI: 10.1038/s41564-018-0334-0

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  23. EBV Viral Loads in Diagnosis, Monitoring, and Response Assessment

    Kimura Hiroshi, Kwong Yok-Lam

    FRONTIERS IN ONCOLOGY   Vol. 9 ( FEB ) page: 62   2019.2

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    DOI: 10.3389/fonc.2019.00062

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  24. Defective Epstein-Barr virus (EBV) in chronic active EBV infection and EBV-related hematological malignancy Reviewed

    Okuno Y, Murata Y, Sato Y, Muramatsu H, YIto Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta1 A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.

    Nat Microbiol     2019.1

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    DOI: 10.1038/s41564-019-0387-8

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  25. Overview of EBV-Associated T/NK-Cell Lymphoproliferative Diseases

    Kimura Hiroshi, Fujiwara Shigeyoshi

    FRONTIERS IN PEDIATRICS   Vol. 6   2019.1

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    DOI: 10.3389/fped.2018.00417

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  26. Clinical features of adult-onset chronic active Epstein-Barr virus infection

    KAWAMOTO Keisuke, MIYOSHI Hiroaki, SETO Masao, KIMURA Hiroshi, OHSHIMA Koichi

    Rinsho Ketsueki   Vol. 60 ( 8 ) page: 944-952   2019

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    <p>Chronic active Epstein-Barr virus infection (CAEBV) presents with mononucleosis-like symptoms such as chronic persistent or recurrent pyrexia, lymphadenopathy, and hepatosplenomegaly because of the reactivation of Epstein-Barr virus (EBV) as demonstrated by the recurrence of EBV-infected cells. The mechanism of CAEBV remains obscure, and CAEBV can lead to fatal conditions such as hemophagocytic syndrome and malignant lymphoma by clonal expansion of EBV-infected T- or NK-cells. Without hematopoietic stem cell transplantation, CAEBV has a poor prognosis. CAEBV is listed in the revised 2016 World Health Organization classification as a chronic active EBV infection of T- and NK-cell types, systemic form, among EBV-positive T- and NK-cell lymphoproliferative diseases of childhood. However, similar clinical conditions have been reported in adult patients. Therefore, we investigated the clinical features of adult patients with CAEBV-like features (adult-onset CAEBV) in a relatively small number of cases. Additionally, genetic alterations related to CAEBV development have also been reported. Along with these results, we reviewed the clinical characteristics of adult-onset CAEBV.</p>

    DOI: 10.11406/rinketsu.60.944

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  27. EBV and Lymphomagenesis

    KIMURA Hiroshi, OKUNO Yusuke

    Uirusu   Vol. 69 ( 1 ) page: 13-22   2019

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    Epstein–Barr virus (EBV) is a double stranded DNA virus of the family Herpesviridae. EBV is associated with a variety of lymphomas, and the mechanisms by which it promotes lymphomagenesis have been elucidated; this includes, for example, by translocation/activation of Myc in Burkitt lymphoma. However, the mechanisms by which it induces lymphoid tumors other than Burkitt lymphoma are unclear. Recently, we reported that the genome of EBV present in EBV-associated lymphomas harbors frequent intragenic deletions and that the deletion of a gene essential for virus replication promotes lymphomagenesis in a mouse model. Although intragenic deletions have been detected in other tumor viruses, little is known about the effects and importance of those of EBV, a large DNA virus whose genome encodes more than 70 genes. In this review, we summarize the role of EBV in lymphomagenesis with a focus on the impact of intragenic deletions.

    DOI: 10.2222/jsv.69.13

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  28. JAK inhibitors for refractory lymphoma.

    Kimura H

    Oncotarget   Vol. 9 ( 68 ) page: 32883 - 32884   2018.8

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    DOI: 10.18632/oncotarget.26054

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  29. Antitumor effects of duvelisib on Epstein-Barr virus-associated lymphoma cells Reviewed

    Kawada Jun-ichi, Ando Shotaro, Torii Yuka, Watanabe Takahiro, Sato Yoshitaka, Ito Yoshinori, Kimura Hiroshi

    CANCER MEDICINE   Vol. 7 ( 4 ) page: 1275-1284   2018.4

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    DOI: 10.1002/cam4.1311

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  30. Regulation of Epstein-Barr Virus Life Cycle and Cell Proliferation by Histone H3K27 Methyltransferase EZH2 in Akata Cells

    Ichikawa Takaya, Okuno Yusuke, Sato Yoshitaka, Goshima Fumi, Yoshiyama Hironori, Kanda Teru, Kimura Hiroshi, Murata Takayuki

    MSPHERE   Vol. 3 ( 6 )   2018

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    DOI: 10.1128/mSphere.00478-18

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  31. BGLF2 Increases Infectivity of Epstein-Barr Virus by Activating AP-1 upon De Novo Infection Reviewed

    Konishi Natsuno, Narita Yohei, Hijioka Fumiya, Al Masud H. M. Abdullah, Sato Yoshitaka, Kimura Hiroshi, Murata Takayuki

    MSPHERE   Vol. 3 ( 2 )   2018

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    DOI: 10.1128/mSphere.00138-18

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  32. EBV in T-/NK-Cell Tumorigenesis.

    Kimura H

    Advances in experimental medicine and biology   Vol. 1045   page: 459-475   2018

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    DOI: 10.1007/978-981-10-7230-7_21

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  33. Human Herpesviruses Preface

    Kimura Hiroshi

    HUMAN HERPESVIRUSES   Vol. 1045   page: V-V   2018

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  34. Chronic Active Epstein-Barr Virus Disease

    Kimura Hiroshi, Cohen Jeffrey I.

    FRONTIERS IN IMMUNOLOGY   Vol. 8   page: 1867   2017.12

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    DOI: 10.3389/fimmu.2017.01867

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  35. A distinct subtype of Epstein Barr virus positive T/NK-cell lymphoproliferative disorder: Adult patients with chronic active Epstein Barr virus infection-like features. Reviewed

    Kawamoto K, Miyoshi H, Suzuki T, Kozai Y, Kato K, Miyahara M, Yujiri T, Oishi N, Choi I, Fujimaki K, Muta T, Kume M, Moriguchi S, Tamura S, Kato T, Tagawa H, Makiyama J, Kanisawa Y, Sasaki Y, Kurita D, Yamada K, Shimono J, Sone H, Takizawa J, Seto M, Kimura H, Ohshima K

    Haematologica     2017.12

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    DOI: 10.3324/haematol.2017.174177

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  36. Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production

    Al Masud H. M. Abdullah, Watanabe Takahiro, Yoshida Masahiro, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi, Murata Takayuki

    JOURNAL OF VIROLOGY   Vol. 91 ( 23 )   2017.12

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    DOI: 10.1128/JVI.00975-17

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  37. Characterization of a Suppressive Cis-acting Element in the Epstein-Barr Virus LMP1 Promoter Reviewed

    Yoshida Masahiro, Murata Takayuki, Ashio Keiji, Narita Yohei, Watanabe Takahiro, Al Masud H. M. Abdullah, Sato Yoshitaka, Goshima Fumi, Kimura Hiroshi

    FRONTIERS IN MICROBIOLOGY   Vol. 8   page: 2302   2017.11

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    DOI: 10.3389/fmicb.2017.02302

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  38. Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia. Reviewed

    Washio K, Oka T, Abdalkader L, Muraoka M, Shimada A, Oda M, Sato H, Takata K, Kagami Y, Shimizu N, Kato S, Kimura H, Nishizaki K, Yoshino T, Tsukahara H

    Leukemia & lymphoma   Vol. 58 ( 11 ) page: 2683-2694   2017.11

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    DOI: 10.1080/10428194.2017.1304762

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  39. The Epstein-Barr Virus BRRF1 Gene is Dispensable for Viral Replication in HEK293 cells and Transformation. Reviewed

    Yoshida M, Watanabe T, Narita Y, Sato Y, Goshima F, Kimura H, Murata T.

    Sci Rep 7   Vol. 7   page: 6044   2017.7

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  40. Elimination of LMP1-expressing cells from a monolayer of gastric cancer AGS cells

    Sato Yoshitaka, Ochiai Shingo, Murata Takayuki, Kanda Teru, Goshima Fumi, Kimura Hiroshi

    ONCOTARGET   Vol. 8 ( 24 ) page: 39345-39355   2017.6

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    DOI: 10.18632/oncotarget.16996

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  41. The C-Terminus of Epstein-Barr Virus BRRF2 Is Required for its Proper Localization and Efficient Virus Production. Reviewed

    Watanabe T, Sakaida K, Yoshida M, Masud HMAA, Sato Y, Goshima F, Kimura H, Murata T

    Frontiers in microbiology   Vol. 8   page: 125   2017

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    DOI: 10.3389/fmicb.2017.00125

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  42. Epstein-Barr virus infection-induced inflammasome activation in human monocytes. Reviewed

    Torii Y, Kawada JI, Murata T, Yoshiyama H, Kimura H, Ito Y.

    PLoS One   Vol. 12 ( 4 ) page: e0175053   2017

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  43. The efficacy of combination therapy with oncolytic herpes simplex virus HF10 and dacarbazine in a mouse melanoma model. Reviewed

    Tanaka R, Goshima F, Esaki S, Sato Y, Murata T, Nishiyama Y, Watanabe D, Kimura H.

    Am J Cancer Res   Vol. 7   page: 1693-170   2017

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  44. Diagnostic values for the viral load in peripheral blood mononuclear cells of patients with chronic active Epstein-Barr virus disease. Reviewed

    Ito Y, Suzuki M, Kawada J, Kimura H.

    J Infect Chemother   Vol. 22   page: 268-271   2016

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  45. Analysis of circulating human and viral microRNAs in patients with congenital cytomegalovirus infection. Reviewed

    Kawano Y, Kawada JI, Kamiya Y, Suzuki M, Torii Y, Kimura H, Ito Y.

    J Perinatol   Vol. 36   page: 1101-1105   2016

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  46. A case of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with severe cardiac complications. Reviewed

    Kawamura Y, Miura H, Matsumoto Y, Uchida H, Kudo K, Hata T, Ito Y, Kimura H, Yoshikawa T.

    BMC Pediatrics   Vol. 16   page: 172   2016

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  47. Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Reviewed

    Ando S, Kawada JI, Watanabe T, Suzuki M, Sato Y, Torii Y, Asai M, Goshima F, Murata T, Shimizu N, Ito Y, Kimura H.

    Oncotarget   Vol. 7   page: 76793-76805   2016

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  48. HSV-2-related hemophagocytic lymphohistiocytosis in a fingolimod-treated MS patient. Reviewed

    Ikumi K, Ando T, Katano H, Katsuno M, Sakai Y, Yoshida M, Saida T, Kimura H, Sobue G.

    Neurol Neuroimmunol Neuroinflamm   Vol. 3 ( 4 ) page: e247   2016

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    DOI: 20160000

  49. Induction of Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 (LMP1) by Transcription Factors Activating Protein 2 (AP-2) and Early B Cell Factor (EBF). Reviewed

    Murata T, Noda C, Narita Y, Watanabe T, Yoshida M, Ashio K, Sato Y, Goshima F, Kanda T, Yoshiyama H, Tsurumi T, Kimura H.

    J Virol   Vol. 90   page: 3873-89   2016

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  50. A case of CAEBV showing features of granulomatosis with polyangiitis. Reviewed

    Shimomura M, Morishita H, Meguro T, Seto S, Kimura M, Hamazaki M, Hashimoto A, Sugiyama Y, Kimura H.

    Pediatr Int   Vol. 58   page: 639-42   2016

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  51. Increased T-cell responses to EBV with high viral load in patients with EBV-positive diffuse large B-cell lymphoma. Reviewed

    Morishima S, Nakamura S, Yamamoto K, Miyauchi H, Kagami Y, Kinoshita T, Onoda H, Yatabe Y, Ito M, Miyamura K, Nagai H, Moritani S, Sugiura I, Tsushita K, Mihara H, Ohbayashi K, Iba S, Emi N, Okamoto M, Iwata S, Kimura H, Kuzushima K, Morishima Y.

    Leukemia & Lymphoma   Vol. 56   page: 1072-8   2015

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  52. Epstein-Barr virus Type 2 latently infects T-cells inducing an atypical activation characterized by expression of lymphotactic cytokines. Reviewed

    Coleman CB, Wohlford EM, Smith NA, King CA, Ritchie JA, Baresel PC, Kimura H, Rochford R

    J Virol   Vol. 89   page: 2301-12   2015

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  53. Viral load in children with congenital cytomegalovirus infection identified on newborn hearing screening. Reviewed

    Kawada J, Torii Y, Kawano Y, Suzuki M, Kamiya Y, Kotani T, Kikkawa F, Kimura H, Ito Y.

    J Clin Virol   Vol. 65   page: 41-5   2015

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  54. Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Reviewed

    Kawano Y, Suzuki M, Kawada JI, Kimura H, Kamei H, Ohnishi Y, Ono Y, Uchida H, Ogura Y, Ito Y.

    Vaccine   Vol. 33   page: 1440-5   2015

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  55. The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas. Reviewed

    Suzuki M, Takeda T, Nakagawa H, Iwata S, Watanabe T, Siddiquey MN, Goshima F, Murata T, Kawada JI, Ito Y, Kojima S, Kimura H.

    Front Microbiol   Vol. 6   page: 280   2015

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  56. Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBVinfected B lymphocytes with TRAbs on their surface. Reviewed

    Nagata K, Nakayama Y, Higaki K, Ochi M, Kanai K, Matsushita M, Kuwamoto S, Kato M, Murakami I, Iwasaki T, Nanba E, Kimura H, Hayashi K.

    Autoimmunity   Vol. 11   page: 1-8   2015

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  57. Roles of Epstein-Barr virus BGLF3.5 Gene and Two Upstream Open Reading Frames in Lytic Viral Replication in HEK293 Cells. Reviewed

    Watanabe T, Fuse K, Takano T, Narita Y, Goshima F, Kimura H, Murata T.

    Virology   Vol. 483   page: 44–53   2015

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  58. The Epstein-Barr virus BRRF2 gene product is involved in viral progeny production. Reviewed

    Watanabe T, Tsuruoka M, Narita Y, Katsuya R, Goshima F, Kimura H, Murata T.

    Virology   Vol. 484   page: 33-40   2015

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  59. A herpesvirus specific motif of Epstein-Barr virus DNA polymerase is required for the efficient lytic genome synthesis. Reviewed

    Narita Y, Sugimoto A, Kawashima D, Watanabe T, Kanda T, Kimura H, Tsurumi T, Murata T.

    Sci Rep   Vol. 5   page: 11767   2015

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  60. Epstein-Barr virus BDLF4 gene is required for efficient expression of viral late lytic genes. Reviewed

    Watanabe T, Narita Y, Yoshida M, Sato Y, Goshima F, Kimura H, Murata T.

    J Virol   Vol. 89 ( 19 ) page: 10120-4   2015

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  61. Current Studies on Chronic Active Epstein-Barr virus Infection in Japan. Invited

    Fujiwara S, Kimura H, Imadome KI, Arai A, Kodama E, Morio T, Shimizu N, Wakiguchi H.

    Pediatr Int   Vol. 56   page: 159-166   2014

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  62. mTOR inhibitors induce cell cycle arrest and inhibit tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Reviewed

    Kawada JI, Ito Y, Iwata S, Suzuki M, Kawano Y, Kanazawa T, Siddiquey MN, Kimura H.

    Clin Cancer Res   Vol. 20   page: 5412-22   2014

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  63. Anti-CCR4 monoclonal antibody mogamulizumab for the treatment of EBV-associated T- and NK-cell lymphoproliferative diseases. Reviewed

    Kanazawa T, Hiramatsu Y, Iwata S, Siddiquey MN, Sato Y, Suzuki M, Ito Y, Goshima F, Murata T, Kimura H.

    Clin Cancer Res   Vol. 20   page: 5075-84   2014

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  64. Role of latent membrane protein 1 (LMP1) in chronic active Epstein-Barr virus infection (CAEBV)-derived T/NK cell proliferation. Reviewed

    Ito T, Kawazu H, Murata T, Iwata S, Arakawa S, Sato Y, Kuzushima K, Goshima F, Kimura H.

    Cancer Med   Vol. 3   page: 787-95   2014

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  65. Anti-tumor effects of suberoylanilide hydroxamic acid on Epstein-Barr virus-associated T- and natural killer- cell lymphoma. Reviewed

    Siddiquey MN, Nakagawa H, Iwata S, Kanazawa T, Suzuki M, Imadome KI, Fujiwara S, Goshima F, Murata T, Kimura H.

    Cancer Sci   Vol. 105   page: 713-722   2014

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  66. Presence of Epstein-Barr virus-infected B lymphocytes with thyrotropin receptor antibodies on their surface in Graves' disease patients and in healthy individuals. Reviewed

    Nagata K, Higaki K, Nakayama Y, Miyauchi H, Kiritani Y, Kanai K, Matsushita M, Iwasaki T, Sugihara H, Kuwamoto S, Kato M, Murakami I, Nanba E, Kimura H, Hayashi K.

    Autoimmunity   Vol. 47   page: 193-200   2014

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  67. Oncolytic viral therapy with a combination of HF10, a herpes simplex virus type 1 variant, and granulocyte-macrophage colony-stimulating factor for murine ovarian cancer. Reviewed

    Goshima F, Esaki S, Luo C, Kamakura M, Kimura H, Nishiyama Y.

    Int J Cancer   Vol. 134   page: 2865-77   2014

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  68. Rare occurrence of JAK3 mutations in NK cell neoplasms in Japan. Reviewed

    Kimura H, Karube K, Ito Y, Hirano K, Suzuki M, Iwata S, Seto M.

    Leukemia & Lymphoma   Vol. 55   page: 962-3   2014

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  69. Modes of infection and oncogenesis by the Epstein-Barr virus. Reviewed

    Murata T, Sato Y, Kimura H.

    Rev Med Virol   Vol. 24   page: 242-253   2014

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  70. Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: a case report. Reviewed

    Kato S, Miyata T, Takata K, Shimada S, Ito Y, Tomita A, Elsayed AA, Takahashi E, Asano N, Kinoshita T, Kimura H, Nakamura S.

    Hum Pathol   Vol. 44   page: 2849-52   2013

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  71. HLA-A*26 and HLA-B*52 are associated with a risk of developing EBV-associated T/NK lymphoproliferative disease. Reviewed

    Ito Y, Suzuki R, Torii Y, Kawa K, Kikuta A, Kojima S, Kimura H.

    Blood e-Letter     page: 8085   2013

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  72. Immunogenicity of inactivated seasonal influenza vaccine in adult and pediatric liver transplant recipients over two seasons. Reviewed

    Suzuki M, Torii Y, Kawada J, Kimura H, Kamei H, Onishi Y, Kaneko K, Ando H, Kiuchi T, Ito Y.

    Microbiol Immunol   Vol. 57   page: 715-22   2013

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  73. Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan. Reviewed

    Ito Y, Kimura H, Torii Y, Hayakawa M, Tanaka T, Tajiri H, Yoto Y, Tanaka-Taya K, Kanegane H, Nariai A, Sakata H, Tsutsumi H, Oda M, Yokota S, Morishima T, Moriuchi H.

    Pediatr Int   Vol. 55   page: 566-571   2013

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  74. Heat shock protein 90 inhibitors repress latent membrane protein 1 (LMP1) expression and proliferation of Epstein-Barr virus-positive natural killer cell lymphoma. Reviewed

    Murata T, Iwata S, Siddiquey NA, Kanazawa T, Goshima F, Kimura H, Tsurumi T.

    PLoS One   Vol. 8   page: e63566   2013

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  75. Different Distributions of Epstein-Barr virus early and late gene transcripts within viral replication compartments. Reviewed

    Sugimoto A, Sato Y, Kanda T, Murata T, Narita Y, Kawashima D, Kimura H, Tsurumi T.

    J Virol   Vol. 87   page: 6693-9   2013

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  76. Plasma viral MicroRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection. Reviewed

    Kawano Y, Iwata S, Kawada J, Gotoh K, Suzuki M, Torii Y, Kojima S, Kimura H, Ito Y.

    J Infect Dis   Vol. 208   page: 771-9   2013

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  77. Clinico-epidemiological states of mother-to-child infections: a nationwide survey in Japan. Reviewed

    Torii Y, Kimura H, Ito Y, Hayakawa M, Tanaka T, Tajiri H, Yoto Y, Tanaka-Taya K, Kanegane H, Nariai A, Sakata H, Tsutsumi H, Oda M, Yokota S, Morishima T, Moriuchi H.

    Pediatr Infect Dis J   Vol. 32   page: 699-701   2013

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  78. Interleukin-17A-producing T lymphocytes in chronic active Epstein-Barr virus infection. Reviewed

    Ohta R, Imai M, Kawada J, Kimura H, Ito Y.

    Microbiol Immunol   Vol. 57   page: 139-44   2013

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  79. A monoclonal expansion of Epstein-Barr virus-infected natural killer cells after allogeneic peripheral blood stem cell transplantation. Reviewed

    Isobe Y, Hamano Y, Ito Y, Kimura H, Tsukada N, Sugimoto K, Komatsu N.

    J Clin Virol   Vol. 56   page: 150-2   2013

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  80. Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication. Reviewed

    Narita Y, Murata T, Ryo A, Kawashima D, Sugimoto A, Kanda T, Kimura H, Tsurumi T.

    J Virol   Vol. 87   page: 2020-7   2013

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  81. Causes of vertical transmission of hepatitis B virus under the at-risk prevention strategy in Japan. Reviewed

    Torii Y, Kimura H, Hayashi K, Suzuki M, Kawada J, Kojima S, Katano Y, Goto H, Ito Y.

    Microbiol Immunol   Vol. 57   page: 118-21   2013

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  82. Enhanced antitumoral activitiy of oncolytic herpes simplex virus with gemcitabine using colorectal tumor models. Reviewed

    Esaki S, Goshima F, Kimura H, Murakami S, Nishiyama Y

    Int J Cancer   Vol. 132   page: 1592-601   2013

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  83. Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus -associated hemophagocytic lymphohistiocytosis. Reviewed

    Ito Y, Kawamura Y, Iwata S, Kawada J, Yoshikawa T, Kimura H.

    Pediatr Blood Cancer   Vol. 60   page: 326-328   2013

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  84. Human herpesvirus 6-associated encephalopathy in a child with Dravet syndrome. Reviewed

    Hiraiwa-Sofue A, Ito Y, Ohta R, Kimura H, Okumura A.

    Neuropediatrics   Vol. 44   page: 155-8   2013

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  85. Remission of juvenile idiopathic arthritis with primary Epstein-Barr virus infection. Reviewed

    Kawada J, Ito Y, Torii Y, Kimura H, Iwata N

    Rheumatol   Vol. 52   page: 956-8   2013

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  86. A probable identical Epstein-Barr virus clone-positive composite lymphoma with aggressive natural killer-cell leukemia and cytotoxic T-cell lymphoma. Reviewed

    Sugimoto KJ, Shimada A, Wakabayashi M, Imai H, Sekiguchi Y, Nakamura N, Sawada T, Ota Y, Takeuchi K, Ito Y, Kimura H, Komatsu N, Noguchi M.

    Int J Clin Exp Pathol   Vol. 15   page: 411-7   2013

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  87. Epstein-Barr virus-associated lymphoid malignancies: the expanding spectrum of hematopoietic neoplasms. Invited

    Kimura H, Kawada J, Ito Y.

    Nagoya J Med Sci   Vol. 75   page: 169-79   2013

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  88. A pediatric case of hepatitis B virus subgenotype A2 in Japan. Reviewed

    Hayashi K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Ito Y, Kimura H, Katano Y, Goto H.

    Clin J Gastroenterol   Vol. 6   page: 383-5   2013

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  89. Prospective Monitoring of Epstein-Barr virus and other Herpesviruses in Patients with Juvenile Idiopathic Arthritis Treated with Methotrexate and Tocilizuma Reviewed

    Kawada J, Iwata N, Kitagawa Y, Kimura H, Ito Y

    Mod Rheumatol     2012

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    DOI: 10.1007/s10165-011-0552-2

  90. Herpes simplex virus requires PARP activity for efficient replication and induces ERK-dependent phosphorylation and ICP0-dependent nuclear localization of tankyrase 1 Reviewed

    Li Z, Yamauchi Y, Kamakura M, Murayama T, Goshima F, Kimura H, Nishiyama Y.

      Vol. 86   page: 492-503   2012

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  91. EBV-associated T/NK lymphoproliferative diseases in non-immunocompromised hosts:prospective analysis of 108 cases Reviewed

    Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, Naoe T, Esaki S, Kikura A, Sawada A, Kawa K, Ohshima K, Nakamura S.

      Vol. 119   page: 673-86   2012

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    DOI: 10.1182/blood-2011-10-381921

  92. Antitumor activities of valproic acid on Epstein-Barr virus-associated T and natural killer lymphoma cells. Reviewed

    Iwata S, Saito T, Ito Y, Kamakura M, Gotoh K, Kawada J, Nishiyama Y, Kimura H

      Vol. 103   page: 375-8   2012

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    DOI: 10.1111/j.1349-7006.2011.02127.x

  93. Hydroa vacciniforme is associated with increased numbers of Epstein-Barr virus-infected γδ T-cells. Reviewed

    Hirai Y, Yamamoto T, Kimura H, Ito Y, Tsuji K, Miyake T, Morizane S, Suzuki D, Fujii K, Keiji Iwatsuki K.

    J Invest Dermatol   Vol. 132   page: 1401-8   2012

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  94. Pretreatment EBV-DNA copy number is predictive of response and toxicities to SMILE chemotherapy for extranodal NK/T-cell lymphoma, nasal type. Reviewed

    Ito Y, Kimura H, Maeda Y, Hashimoto C, Ishida F, Izutsu K, Sueoka E, Isobe Y, Takizawa J, Hasegawa Y, Kobayashi H, Okamura S, Kobayashi H, Yamaguchi M, Suzumiya J, Hyo R, Nakamura S, Kawa K, Oshimi K, Suzuki R.

    Clin Cancer Res   Vol. 18   page: 4183-4190   2012

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  95. Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T-NK lymphoproliferative diseases. Reviewed

    Kawabe S, Ito Y, Gotoh K, Kojima S, Matsumoto K, Kinoshita T, Iwata S, Nishiyama Y, Kimura H.

    Cancer Sci   Vol. 103   page: 1481-8   2012

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  96. Diabetic mice show an aggravated course of herpes-simplex-virus-induced facial nerve paralysis. Reviewed

    Esaki S, Yamano K, Kiguchi J, Katsumi S, Keceli S, Okamoto H, Goshima F, Kimura H, Nishiyama Y, Murakami S.

    Otol Neurotol   Vol. 33   page: 1452-7   2012

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  97. Perinatal cytomegalovirus-associated bullae in an immunocompetent infant. Arch Dermatol Reviewed

    Yasuda K, Sugiura K, Ishikawa R, Kihira M, Negishi Y, Iwayama H, Ito K, Kimura H, Kosugi I, Akiyama M.

    Arch Dermatol   Vol. 148   page: 770-2   2012

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  98. Immunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2. Reviewed

    Luo C, Goshima F, Kamakura M, Mutoh Y, Iwata S, Kimura H, Nishiyama Y.

    Front Microbiol   Vol. 3   page: 158   2012

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  99. T/NK-cell type chronic active Epstein-Barr virus (EBV) disease in adults: an underlying condition for EBV-associated T/NK-cell lymphoma. Reviewed

    Isobe Y, Aritaka N, Setoguchi Y, Ito Y, Kimura H, Hamano Y, Sugimoto K, Komatsu N.

    J Clin Pathol   Vol. 65   page: 278-82   2012

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  100. Generation and characterization of UL21-null herpes simplex virus type 1 Reviewed

    Muto Y, Goshima F, Ushijima Y, Kimura H, Nishiyama Y

    Front Microbiol   Vol. 3   page: 394   2012

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  101. EBV-associated T and NK cell lymphoproliferative disorders: Consensus report of the 4th Asian Hematopathology Workshop. Reviewed

    Ko Y-H, Kim H-J, Oh Y-H, Park G, Lee S-S, Huh J, Kim C-W, Kim I, Ng S-B, Tan S-Y, Chuang S-S, Nakamura N, Yoshino T, Nakamura S, Kimura H, Ohshima K.

    J Hematopathol   Vol. 5   page: 319-324   2012

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  102. Replication of Epstein-Barr virus primary infection in human tonsil tissue explants Reviewed

    Gotoh K, Ito Y, Maruo S, Takada K, Mizuno T, Teranishi M, Nakata S, Nakashima T, Iwata S, Goshima F, Nakamura S, Kimura H

    PLoS One   Vol. 6   page: e25490   2011

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  103. Kinetics of Epstein-Barr Virus Load and Virus-Specific CD8+ T Cells in Acute Infectious Mononucleosis. Reviewed

    Hoshino Y, Nishikawa K, Ito Y, Kuzushima K, Kimura H.

    J Clin Virol   Vol. 50   page: 244-246   2011

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  104. Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients. Reviewed

    Torii Y, Kimura H, Gotoh K, Ochi N, Kaneko K, Ando H, Kiuchi T, Ito Y.

    Vaccine   Vol. 29   page: 4187-4189   2011

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  105. Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza. Reviewed

    Ohta R, Torii Y, Imai M, Kimura H, Okada N, Ito Y.

    Microbiol Immunol   Vol. 55   page: 191-198   2011

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  106. Unrelated bone marrow transplantation induced long-term remission in a patient with life-threatening epstein-barr virus-associated hemophagocytic lymphohistiocytosis. Reviewed

    Kunitomi A, Kimura H, Ito Y, Naitoh K, Noda N, Iida H, Sao H.

    J Clin Exp Hematop   Vol. 51   page: 57-61   2011

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  107. Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0. Reviewed

    Kamakura M, Goshima F, Luo C, Kimura H, Nishiyama Y.

    Virology J   Vol. 8   page: 257   2011

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  108. Auditory and Vestibular Defects Induced by Experimental Labyrinthitis Following Herpes Simplex Virus in Mice. Reviewed

    Esaki S, Goshima F, Kimura H, Ikeda S, Katsumi S, Kabaya K, Watanabe M, Hashiba M, Nishiyama Y, Murakami S.

    Acta Oto-Laryngologica   Vol. 131   page: 684-691   2011

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  109. Bortezomib Induces Apoptosis in T Lymphoma Cells and Natural Killer Lymphoma Cells Independent of Epstein-Barr Virus Infection. Reviewed

    Iwata S, Yano S, Ito Y, Ushijima Y, Gotoh K, Kawada J, Fujiwara S, Sugimoto K, Isobe Y, Nishiyama Y, Kimura H.

    Int J Cancer   Vol. 129   page: 2263-2273   2011

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  110. Hepatocyte growth factor incorporated into herpes simplex virus vector accelerates facial nerve regeneration after crush injury. Reviewed

    Esaki S, Kitoh J, Katsumi S, Goshima F, Kimura H, Safwat M, Yamano K, Watanabe N, Nonoguchi N, Nakamura T, Coffin RS, Miyatake S, Nishiyama Y, Murakami S.

    Gene Therapy     page: in press   2011

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  111. Elevated expression of activation-induced cytidine deaminase in T and NK cells from patients with chronic active Epstein-Barr virus infection. Reviewed

    Nakamura M, Iwata S, Kimura H, TokuraY.

    Eur J Dermatol   Vol. 21   page: 780-2   2011

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  112. Chronological changes in Epstein-Barr virus genome and subsets of peripheral mononuclear cells in a case of HLH. Reviewed

    Ukeba-Terashita Y, Saita Y, Ito Y, Kanegane H, Kimura H, Kobayashi I.

    Open Journal of Pediatrics     page: in press   2011

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  113. Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type: the NK-cell Tumor Study Group (NKTSG) study. Reviewed

    Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R.

    J Clin Oncol   Vol. 29   page: 4410-4416   2011

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  114. Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children. Reviewed

    Ito Y, Torii Y, Ohta R, Imai M, Hara S, Kawano Y, Matsubayashi T, Inui A, Yoshikawa T, Nishimura N, Ozaki T, Morishima T, Kimura H.

    Cytokine     page: in press   2011

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  115. Clinicopathological analysis of the age-related differences in patients with Epstein-Barr virus-associated extranasal NK/T-cell lymphoma with reference to the relationship with aggressive NK cell leukemia and chronic active Epstein-Barr virus infection-associated lymphoproliferative disorder. Reviewed

    Takahashi E, Ohshima K, Kimura H, Hara K, Suzuki R, Kawa K, Eimoto T, Nakamura S.

    Histopathology   Vol. 59   page: 660-67   2011

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  116. Relationship between lower respiratory tract infections caused by respiratory syncytial virus and the subsequent development of asthma in Japanese children. Reviewed

    Narita A, Nishimura N, Arakawa Y, Suzuki M, Sakamoto K, Sakamoto M, Hosono H, Yamamoto Y, Kimura H, Ozaki T.

    Jap J Infect Dis     page: in press   2011

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  117. Herpes simplex virus type 1 UL14 tegument protein regulates intracellular compartmentalization of major tegument protein VP16. Reviewed

    Ohta A, Yamauchi Y, Muto Y, Kimura H, Nishiyama Y.

    Virology J   Vol. 26   page: 365   2011

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  118. Identification of Epstein-Barr virus-infected CD27+ memory B cells in patients after transplantation. Reviewed

    Ito Y, Kawabe S, Kojima S, Nakamura F, Nishiyama Y, Kaneko K, Kiuchi K, Ando H, Kimura H.

    J Gen Virol   Vol. 192   page: 2590-5   2011

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  119. Quantitative Analysis of Epstein-Barr Virus (EBV)-Related Gene Expression in Patients with Chronic Active EBV infection. Invited Reviewed

    Iwata, S., Wada, K., Tobita, S., Gotoh, K., Ito, Y., Demachi-Okamura, A., Shimizu, N., Nishiyama, Y. and Kimura, H.

    J Gen Virol   Vol. 90   page: 42-50   2010

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  120. Transmission of cytomegalovirus via breast milk in extremely premature infants. Invited Reviewed

    Hayashi S, Kimura H, Oshiro M, Kato Y, Yasuda A, Suzuki C, Watanabe Y, Morishima T, Hayakawa M.

    J Perinatol     page: in press   2010

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  121. Effectiveness and safety of inactivated influenza vaccination in pediatric liver transplant recipients over three influenza seasons. Invited Reviewed

    Gotoh K, Ito Y, Suzuki E, Kaneko K, Kiuchi T, Ando H, Kimura H.

    Pediatr Transplant     page: in press   2010

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  122. Detection of EBV genomes in plasmablasts/plasma cells and non-B cells in the blood of most patients with EBV lymphoproliferative disorders using Immuno-FISH. Invited Reviewed

    Calatini S, Sereti I, Scheinberg P, Kimura H, Childs R, Cohen JI.

    Blood     page: in press   2010

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  123. Multicenter evaluation of prototype real-time PCR assays for Epstein-Barr virus and cytomegalovirus DNA in whole blood samples from transplant recipients" in its current form for publication in Microbiology and Immunology. Invited Reviewed

    Ito Y, Takakura S, Ichiyama S, Ueda M, Ando Y, Matsuda K, Hidaka E, Nakatani A, ishioka J, Nobori T, Sasaki M, Kimura H.

    Microbiol Immunol   Vol. 54   page: 516-522   2010

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  124. Herpes simplex virus UL56 interacts with and regulates the Nedd4-family ubiquitin ligase Itch. Invited Reviewed

    Ushijima Y, Luo C, Kamakura M, Goshima F, Kimura H, Nishiyama Y.

    Virology J   Vol. 7   page: 179   2010

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  125. Comparison of the cerebrospinal fluid levels and serum concentrations of human herpesvirus 6 (HHV-6) DNA and cytokines in children with HHV-6 encephalopathy. Invited Reviewed

    Kawabe S, Ito Y, Ohta R, Sofue A, Gotoh K, Morishima T, Kimura H.

    J Med Virol   Vol. 82   page: 1410-1415   2010

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  126. Immunologic and Virologic Analyses in Pediatric Liver Transplant Recipients with Chronic High Epstein-Barr Viral Loads Reviewed

    Gotoh K, Ito Y, Ohta R, Iwata S, Nishiyama Y, Nakamura T, Kaneko K, Kiuchi T, Ando H, Kimura H.

    J Infect Dis   Vol. 202   page: 461-469   2010

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  127. Multiplex Real-time PCR Assay for Quantifying BK Polyomavirus, JC Polyomavirus, and Adenovirus DNA Simultaneously Reviewed

    Funahashi Y, Iwata S, Ito Y, Kojima, Yoshikawa T, Hattor R, Gotoh M, Nishiyama Y, Kimura H.

    J Clin Microbiol   Vol. 48   page: 825-830   2010

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  128. Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7. Invited Reviewed

    Wada K, Mizoguchi S, Ito Y, Kawada J, Yamauchi Y, Morishima T, Nishiyama Y, Kimura H.

    Microbiol Immunol   Vol. 53 ( 1 ) page: 22-29   2009

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  129. Epstein-Barr virus Associated Lymphoproliferative Disease in Non-Immunocompromised Hosts. Reviewed

    Cohen JI, Kimura H, Nakamura S, Ko Y-H, Jaffe ES.

    Ann Oncol   Vol. 20   page: 1472-82   2009

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  130. Hepatocellular apoptosis associated with cytotoxic T/naturalkiller-cell infiltration in chronic active EBV infection. Reviewed

    Nomura Y, Kimura H, Karube K, Yoshida S, Sugita Y, Niino D, Shimizu K, Kimura Y, Aoki R, Kiyasu J, Takeuchi M, Hashikawa K, Hirose S, Ohshima K.

    Pathol Int   Vol. 59   page: 438–442   2009

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  131. Cytomegalovirus and Epstein–Barr virus coinfection in three toddlers with prolonged illness. Reviewed

    Ito Y, Shibata-Watanabe Y, Kawada J, Maruyama K, Yagasaki H, Kojima S, Kimura H.

    J Med Virol   Vol. 81   page: 1399-1402   2009

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  132. Acute retinal necrosis caused by herpes simplex virus type 2 in a 3- year-old Japanese boy. Reviewed

    Tanaka-Kitajima N, Iwata N, Ando Y, Sakurai H, Iwami M, Tsuzuki K, Kondo M, Ito Y, Kimura H.

    Eur J Pediatr   Vol. 168   page: 1125-28   2009

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  133. UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions Reviewed

    Ushijima Y, Goshima F, Kimura H, Nishiyama Y.

    Virology J   Vol. 6   page: 168   2009

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  134. *Identification of Epstein-Barr Virus (EBV)-Infected Lymphocyte Subtypes by Flow Cytometric In Situ Hybridization in EBV-Associated Lymphoproliferative Diseases. Reviewed

    Kimura H, Miyake K, Yamauchi Y, Nishiyama K, Iwata S, Iwatsuki K, Gotoh K, Kojima S, Ito Y, Nishiyama Y.

    J Infect Dis   Vol. 200 ( 7 ) page: 1078-1087   2009

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  135. Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss. Invited Reviewed

    Mizuno T, Sugiura S, Kimura H, Ando Y, Sone M, Nishiyama Y, Nakashima T.

    Eur Arch Otorhinolaryngol.   Vol. 266 ( 3 ) page: 351-355   2009

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  136. Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease. Reviewed

    Kimura H, Ito Y, Suzuki R, Nishiyama Y.

    Rev Med Virol   Vol. 18   page: 305-319   2008

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  137. Conversion From Mycophenolate Mofetil to Mizoribine for Patients With Positive Polyomavirus Type BK in Urine. Reviewed

    Funahashi Y, Hattori R, Kinukawa T, Kimura H, Nishiyama Y, Gotoh M.

    Transplant Proc   Vol. 40   page: 2268-2270   2008

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  138. Simultaneous monitoring by real-time PCR of Epstein-Barr virus, human cytomegalovirus, and human herpesvirus 6 in juvenile and adult liver transplant recipients. Reviewed

    OnoY, Ito Y, Kaneko K, Shibata-Watanabe Y, Tainaka T, Sumida W, Nakamura T, Kamei H, Kiuchi T, Ando H, Kimura H.

    Transplant Proc   Vol. 40   page: 3578-82   2008

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  139. Prognostic Factors in Influenza-Associated Encephalopathyモ Reviewed

    Nagao T, Morishima T, Kimura H, Yokota S, Yamashita N, Ichiyama T, Kurihara M, Miyazaki C, Okabe N.

    Pediat Infect Dis J   Vol. 27   page: 384-389   2008

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  140. One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein-Barr virus infection. Reviewed

    Kubota, N., Wada, K., Ito, Y., Shimoyama, Y., Nakamura, S., Nishiyama, Y., and Kimura, H.

    Journal of Virological Methods   Vol. 147   page: 26-36   2008

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  141. The UL14 Tegument Protein of Herpes Simplex Virus Type 1 (HSV-1) is Required for Efficient Nuclear Transport of the Alpha Transinducing Factor VP16 and Viral Capsids. Reviewed

    Yamauchi Y, Kiriyama K, Kubota N, Kimura H, Usukura J, Nishiyama Y.

    Journal of Virology   Vol. 82   page: 1094-1106   2008

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  142. Clinical and virologic characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation Reviewed

    Gotoh K, Ito Y, Shibata-Watanabe Y, Kawada J, Takahashi Y, Yagasaki H, Kojima S, Nishiyama Y, Kimura H.

    Clinical Infectious Disease   Vol. 46   page: 1525-1534   2008

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  143. Oligonucleotide Microarray Analysis of Gene Expression Profiles followed by a Real-time RT-PCR Assay in Chronic Active Epstein-Barr Virus Infection. Reviewed

    Ito Y, Shibata-Watanabe Y, Ushijima Y, Kawada J, Nishiyama Y, Kojima S, Kimura H.

    Journal of Infectious Disease   Vol. 197   page: 663-666   2008

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  144. Measles Outbreak in Adolescent. Invited

    Kimura, H. and Nishiyama, Y.

    JMA Journal     page: in press   2008

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  145. Herpes Simplex Virus Type 2 UL56 Interacts with the Ubiquitin Ligase Nedd4 and Increases its Ubiquitination. Reviewed

    Ushijima Y, Koshizuka T, Goshima F, Kimura H, Nishiyama Y.

    J Virol   Vol. 82   page: 5220-5233   2008

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  146. Herpes Simplex Virus Induces Extensive Modification and Dynamic Relocalisation of the Nuclear Mitotic Apparatus Protein (NuMA) in Interphase Cells Reviewed

    Yamauchi, Y., Kiriyama, K., Kimura, H. and Nishiyama, Y.

    Journal of Cell Science   Vol. 121   page: 2087-2096   2008

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  147. Detection of cytomegalovirus DNA in preserved umbilical cords from patients with sensorineural hearing loss. Reviewed

    Mizuno T, Sugiura S, Kimura H, Ando Y, Sone M, Nishiyama Y, Nakashima T.

    Eur Arch Otorhinolaryngol     page: in press   2008

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  148. Replication-competent, oncolytic herpes simplex virus type 1 mutants induce a bystander effect following gancyclovir treatment. Reviewed

    Luo C, Mori I, Ushijima Y, Nawa A, Kimura H, Nishiyama Y.

    J Gene Med   Vol. 9   page: 875-883   2007

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  149. Association of transforming growth factor-b1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases. Reviewed

    Hatta K, Morimoto A, Ishii E, Kimura H, Ueda I, Hibi S, Todo S, Sugimoto T, Imashuku S.

    Haematologica   Vol. 92   page: 1470-1474   2007

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  150. Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. Reviewed

    Tohyama M, Hashimoto K, Yasukawa M, Kimura H, Horikawa T, Nakajima K, Urano Y, Matsumoto K, Iijima M, Shear NH.

    Br J Dermatol   Vol. 157   page: 934-940   2007

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  151. Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Reviewed

    Ushijima Y, Luo C, Goshima F, Yamauchi Y, Kimura H, Nishiyama Y.

    Microbes and Infection   Vol. 9   page: 142-149   2007

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  152. Simultaneous quantification of Epstein-Barr virus, Cytomegalovirus, and human Herpesvirus 6 DNA in transplant recipients by multiplex real-time PCR assay. Reviewed

    Wada, K., Kubota, N., Ito, Y., Yagasaki, H., Kato, K., Yoshikawa, T., Ono, Y., Ando, H., Fujimoto, Y., Kiuchi, T., Kojima, S., Nishiyama, Y. and Kimura H.

    Journal of Clinical Microbiology   Vol. 45   page: 1426-1432   2007

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    複数の蛍光プローブを用いたマルチプレックスリアルタイムPCR法により,EBV,, CMV, HHV-6の三つのウイルスを同時定量するシステムを構築し,造血幹細胞・臓器移植医療に応用可能なことを示した.

  153. Analysis of Gene Expression Profiles byOligonucleotide Microarray in Children with Influenza. Reviewed

    Kawada J,Kimura H , Kamachi Y, Nishikawa K, Taniguchi M, Nagaoka K, Kurahashi H, Kojima S, Morishima T.

    J Gen Virol   Vol. 87   page: 1677-1683   2006

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    インフルエンザに対する宿主反応のメカニズムを明らかにするために,マイクロアレイを用い,インフルエンザ罹患小児末梢血中の遺伝子発現を網羅的解析した.発現亢進していた遺伝子群は,免疫反応遺伝子群に属するものが多く,インターフェロン制御遺伝子が強く発現亢進していた.熱性痙攣群では,痙攣の無かった群に比べ,22遺伝子の発現が亢進し5つの遺伝子が発現減弱していた.

  154. Fatal Varicella Infection in a Girl with Systemic Lupus Erythematosus after Oral Acyclovir Prophylaxis. Reviewed

    Hirose I, Ymamaguchi H, Inagaguma D, Ono K, Shimada S, Kawada J, Shiraki K, Kimura H.

    Eur J Pediatr   Vol. 165   page: 280-1   2006

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  155. Association of virus infected-T cell in severe hepatitis caused by primary Epstein-Barr virus infection. Reviewed

    Hara S, Hoshino Y, Naitou T, Nagano K, Iwai M, Suzuki K, Yamamoto K, Nagasaka T, Morishima T, Kimura H.

    J Clinical Virol   Vol. 35   page: 250-256   2006

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  156. Chronic Active Epstein-Barr Virus Infection Invited

    Kimura H

    New Development in Epstein-Barr Virus Research     page: 55-70   2006

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  157. Chronic active Epstein-Barr virus infection with dilatation of the Valsalva sinus. Reviewed

    Sato Y, Tsuboi T, Mikami T, Kurosawa H, Kanou K, Sugita K, Kimura H , Nagasaka T, Imashyuku S, Eguchi M.

    Pediatr Int   Vol. 48   page: 643-645   2006

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  158. Rapid detection of Epstein-Barr virus DNA by loop-mediated isothermal amplification method. Reviewed

    Iwata S, Shibata Y , Kawada J, Hara S, Nishiyama Y, Morishima T, Ihira M, Yoshikawa T, Asano Y, Kimura H .

    J Clin Virol   Vol. 37   page: 128-133   2006

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  159. Pathogenesis of chronic active Epstein-Barr virus infection: Is this an infectious disease, lymphoproliferative disorder, or immunodeficiency? Reviewed

    Kimura H.

    Rev Med Virol   Vol. 16   page: 251-261   2006

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    慢性活動性EBウイルス感染症は,EBウイルスが感染したリンパ球が増殖・全身に浸潤することにより生じるリンパ増殖性疾患である.本論文では,慢性活動性EBウイルス感染症の発症病理について,ウイルス学的,免疫学的,腫瘍学的見地から論じている.

  160. Quantitative analysis of herpesvirus load in the lymph nodes of patients with histiocytic necrotizing lymphadenitis using a real-time PCR assay. Reviewed

    Maeda N et al,

    Diagnostic Molecular Pathology   Vol. 15   page: 49-55   2006

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  161. Clonality Analysis by Sequence Variation of the Latent Membrane Protein 1 Gene in Patients with Chronic Active Epstein ?Barr Virus Infection. Reviewed

    Shibata Y,Hoshino Y, Hara S, Yagasaki H, Kojima S, Nishiyama Y, Morishima M, Kimura H .

    J Med Virol   Vol. 78   page: 770-779   2006

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  162. Evaluation of Apoptosis in Epstein-Barr Virus-Associated Haemophagocytic Lymphohistiocytosis. Reviewed

    Kawada J, Kimura H , Shibata Y, Hara S, Hoshino Y, Kojima S, Nishikawa K, Morishima T.

    J Mel Virol   Vol. 17 ( 78 ) page: 400-407   2006

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  163. *Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection. Reviewed

    Kimura H, Hoshino Y, Hara S, Sugaya N, Kawada J, Shibata Y, Kojima S, Nagasaka T, Kuzushima K, Morishima T.

    J Infect Dis   Vol. 191   page: 531-539   2005

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    慢性活動性EBウイルス感染症はEBウイルスがT細胞もしくはNK細胞に感染することによって生じる難治性疾患である.本疾患の発症病理を解明するために,T細胞感染群,NK細胞感染群について,ウイルス学・免疫学的な解析を行った.

  164. Virological aspects of Epstein-Barr virus infections. Reviewed

    Yamashita N, Kimura H, Morishima T.

    Acta Med Okayama.   Vol. 59   page: 239-46   2005

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  165. Proposed guidelines for diagnosing chronic active epstein-barr virus infection Reviewed

    Okano M, Kawa K, Kimura H, Yachie A, Wakiguchi H, Ohga S, Maeda M, Kanegane H, Imai S, Tsuchiya S, Morio T, Mori M, Yokota S, Imashuku S.

    Am J Hematol   Vol. 80   page: 64-9   2005

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  166. Drug-Induced Hypersensitivity Syndrome due to Mexiletine Associated with Human Herpes Virus 6 and Cytomegalovirus Reactivation. Reviewed

    Sekiguchi A, Kashiwagi T, Ishida-Yamamoto A, Takahahi H, Hashimoto Y, Kimura H, Tohyama M, Hashimoto K, Iizuka H.

    J Dermatol   Vol. 32   page: 278-281   2005

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  167. Rapid detection of herpes simplex virus DNA in cerebrospinal fluid: comparison between loop-mediated isothermal amplification and real-time PCR. Reviewed

    Kimura H, Ihira M, Enomoto Y, Kawada J, Ito Y, Morishima T, Yoshikawa T, Asano Y.

    Med Microbiol Immunol   Vol. 194   page: 181-185   2005

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  168. Association of cytomegalovirus with infantile hepatitis. Reviewed

    Shibata Y, Kitajima N, Kawada J, Sugaya N, Nishikawa K, T Morishima T, Kimura H.

    Microbiol Immunol   Vol. 49   page: 771-777   2005

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  169. Congenital Cytomegalovirus Infection Diagnosed by Polymerase Chain Reaction With the Use of Preserved Umbilical Cord. Reviewed

    Kakizawa H, Okumura A, Suzuki Y, Natsume J, Kimura H, Negoro T, Watanabe K.

    Pediatr Infect Dis J   Vol. 24   page: 653-654   2005

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  170. Herpes simplex virus type 1 UL51 protein is involved in maturation and egress of virus particles. Reviewed

    Nozawa N, Kawaguchi Y, Tanaka M, Kato A, Kimura H, Nishiyama Y.

    J Virol   Vol. 79   page: 6947-6956   2005

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  171. Ganciclovir therapy in congenital cytomegalovirus infection in six infants. Reviewed

    Tanaka-Kitajima N, Sugaya N, Futatani T, Kanegane H, Suzuki C, Oshiro M, Hayakawa M, Futamura M, Morishima T, Kimura H.

    Pediatr Infect Dis J   Vol. 24   page: 782-785   2005

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  172. Fatal natural killer cell lymphoma arising in a patient with a crop of Epstein-Barr virus-associated disorders. Reviewed

    Nitta Y, Iwatsuki K, Kimura H, Kojima S, Morishima T, Tsuji K, Oono T.

    Eur J Dermatol   Vol. 15   page: 503-506   2005

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  173. Chronic active Epstein-Barr virus infection associated with mutations in Perforin that impair its maturation. Reviewed

    Katano H, Ali MA, Patera AC, Catalfamo M, Henkart PA, Jaffe ES, Kimura H, Dale JK, Straus SE, Cohen JI.

    Blood   Vol. 103   page: 1244-1252   2004

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    近年,Perforin遺伝子は家族性血球貪食性リンパ増殖症の責任遺伝子として同定されている.本研究は,EBウイルス感染により重症・慢性化した児にPerforin遺伝子欠損を見出し,Fasが関与しないPerforinによる細胞障害能の低下により慢性のEBウイルス感染が生じている可能性を示した.

  174. Pharmacokinetics and Effects of Ribavirin following Intraventricular Administration for Treatment of Subacute Sclerosing Panencephalitis. Reviewed

    Hosoya M. Mori S. Tomoda A. Mori K. Sawaishi Y. Kimura H. Shigeta S. Suzuki H.

    Antimicrob Agents Ch   Vol. 48   page: 4631-4635   2004

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  175. Quantitative analysis of Epstein-Barr virus (EBV)-specific CD8+ T cells in chronic active EBV infection. Reviewed

    Sugaya N, Kimura H, Hara S, Hoshino Y, Kojima S, Morishima T, Tsurumi T, Kuzushima K.

    J Infect Dis   Vol. 190   page: 985-988   2004

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  176. Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection. Reviewed

    Kawada J, Kimura H, Ito Y, Ando Y, Tanaka-Kitajima N, Hayakawa M, Nunoi H, Endo F, MD, Morishima T.

    J Infect Dis   Vol. 190   page: 494-498   2004

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  177. Himiconvulsion-hemiplegia syndrome and primary human herpesvirus 7 infection. Reviewed

    Kawada J, Kimura H, Yoshikawa T, Ihira M, Okumura A, Morishima T, Hayakawa F.

    Brain Dev   Vol. 6   page: 412-414   2004

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  178. Comparison of real-time and nested PCR assays for detection of herpes simplex virus DNA. Reviewed

    Kawada J, Kimura H, Ito Y, Hoshino Y, Tanaka-Kitajima N, Ando Y, Futamura M, Morishima T.

    Microbiol Immunol   Vol. 48   page: 411-415   2004

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  179. Monitoring herpesvirus DNA in three cases of acute retinal necrosis by real-time PCR. Reviewed

    Asano S, Yoshikawa T, Kimura H, Enomoto Y, Ohashi M, Terasaki H, Nishiyama Y.

    J Clin Virol   Vol. 29   page: 206-209   2004

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  180. A case of a long-time survivor with chronic active Epstein-Barr virus infection. Reviewed

    3) Takeoka Y, Nakao Y, Ueda M, Koh KR, Aoyama Y, Nakamae H, Yamamura R, Ohta K, Takubo T, Yamane T, Hino M, Tokura Y, Ishihara S, Oshima K, Kimura H, Imashuku S.

    Eur J Haematol   Vol. 72   page: 73-76   2004

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  181. Influenza Virus and Febrile Convulsions. Reviewed

    Kawada J, Kimura H, Morishima T.

    J Infect Dis   Vol. 189   page: 564-565   2004

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  182. Prognostic factors for chronic active Epstein-Barr virus infection. Reviewed

    Kimura H, Morishima T, Kanegane H, Ohga S, Hoshino Y, Maeda A, Imai S, Okano M, Morio T, Yokota S, Tsuchiya S, Yachie A, Imashuku S, Kawa K, Wakiguchi H.

    J Infect Dis   Vol. 187   page: 527-533   2003

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  183. Absence of Associations between Influenza-Associated Encephalopathy and Human Herpesvirus 6 or Human Herpesvirus 7. Reviewed

    Kawada J, Kimura H, Ito Y, Hara S, Kawashima H, Okuno T, Morishima T.

    Pediatr Infect Dis J   Vol. 22   page: 115-119   2003

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  184. Possibility of preventive treatment for EBV-associated NK cell-lineage proliferative disorders. Reviewed

    Ishii M, Yamaguchi N, Oshima S, Ishii T, Mori KL, Kimura H, Morishima T, Kawase I, Saeki Y.

    Intern Med   Vol. 3   page: 250-254   2003

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  185. Evaluation of cytomegalovirus infections transmitted via breast milk in preterm infants with a real-time polymerase chain reaction assay. Reviewed

    Yasuda A, Kimura H, Hayakawa M, Oshiro M, Kato Y, Matsuura O, Suzuki C, Morishima T.

    Pediatr   Vol. 111   page: 1333-1336   2003

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  186. Epstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disorder simultaneously affecting both B and T cells after allogeneic bone marrow transplantation. Reviewed

    Chuhjo T, Yachie A, Kanegane H, Kimura H, Siobara S, Nakao S.

    Am J Hematol   Vol. 72   page: 255-258   2003

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  187. Varicella Exposure in the neonatal medicine: control measurements by prophylactic acyclovir administration. Reviewed

    Hayakawa M, Ohshiro M, Kato Y, Fukami E, yasuda A, Okumura A, Kimura H, Morishima T.

    J Hospital Infect   Vol. 54   page: 212-215   2003

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  188. Combination therapy with intraventricular interferon-a and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay. Reviewed

    Hara S, Kimura H, Hoshino Y, Hayashi N, Negoro T, Okumura A, Kajita Y, Sakuma T, Nakayama T, Hosoya M, Tomoda A, Morishima T.

    Brain Dev   Vol. 25   page: 367-369   2003

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  189. Trial of Intraventricular Ribavirin Therapy for Subacute Sclerosing Panencephalitis in Japan. Reviewed

    Tomoda A, Nomura K, Shiraishi S, Hamada A, Ohmura T, Hosoya M, Miike T, Sawaishi Y, Kimura H, Takashima H, Tohda Y, Mori K, Kato Z, Fukushima A, Nishio H, Nezu A, Nihei K.

    Brain Dev   Vol. 25   page: 514-517   2003

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  190. Relapse of Neonatal Herpes Simplex Virus Infection. Reviewed

    Kimura H, Futamura M, Ito Y, Ando Y, Hara S, Sobajima H, Nishiyama Y, Morishima T.

    Arch Dis Child Fetal Neonatal Ed   Vol. 88   page: 483-486   2003

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  191. Flow cytometoric analysis of cytomegalovirus-specific cell-mediated immunity in the congenital infection. Reviewed

    Hayashi N, Kimura H, Morishima T, Tanaka N, Tsurumi T, Kuzushima K.

    J Med Virol   Vol. 71   page: 251-258   2003

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  192. Systemic Cytokine Responses in Patients with Influenza-Associated Encephalopathy.

    Kawada J, Kimura H, Ito Y, Hara S, Iriyama I, Yoshikawa T, Morishima T.

    J Infect Dis   Vol. 188   page: 690-698   2003

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  193. Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2. Reviewed

    Kimura H, Ito Y, Futamura M, Ando Y, Yabuta Y, Hoshino Y, Nishiyama Y, Morishima T.

    J Med Virol   Vol. 67   page: 349-353   2002

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  194. Fatal adult case with severe lymphocytopenia associated with reactivation of human herpesvirus 6. Reviewed

    Yoshikawa T, Ihira M, Asano Y, Tomitaka A, Suzuki K, Matsunaga K, Kato Y, Hiramitsu S, Nagai T, Tanaka N, Kimura H, Nishiyama Y.

    J Med Virol   Vol. 66   page: 82-85   2002

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  195. Detection of herpesvirus DNA in the serum of immunocompetent children. Reviewed

    Hara S, Kimura H, Hoshino Y, Tanaka N, Nishikawa K, Ihira M, Yoshikawa T, Morishima T.

    Microbiol Immunol   Vol. 46   page: 177-180   2002

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  196. Helicobacter pylori infection in patients with idiopathic short stature. Reviewed

    Takahashi M, Kimura H, Watanabe K.

    Pediatrics International   Vol. 44   page: 277-280   2002

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  197. Epstein-Barr virus specific T cell cytotoxicity is mediated through the perforin pathway in patients with lymphoproliferative disorders after allogeneic bone marrow transplantation. Reviewed

    Yoshimi A, Tsuge I, Namizaki H, Hoshino Y, Kimura H, Takahashi Y, Watanabe N, Kuzushima K, Kojima S.

    Br J Heamatol   Vol. 116   page: 710-715   2002

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  198. Natural Killer Cell Proliferation and Circulating Cytokines in Patients with Bilateral Basal Ganglia Calcification, Reviewed

    Morishima T, Morita M, Kato T, Hoshino Y, Kimura H.

    Eur J Neurol   Vol. 9   page: 521-525   2002

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  199. Viral Load in Epsten-Barr Virus-Associated Hemophagocytic syndrome, Reviewed

    Kimura H, Hoshino Y, Hara S, Nishikawa K, Sako M, Hirayama M, Komada Y, Morishima T.

    Microbiol Immunol   Vol. 46   page: 579-582   2002

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  200. Expression of tegment protein pp65 of Human cytomegalovirus (CMV) and its application for the analysis of viral-specific cellular immunity in CMV-infected individuals, Reviewed

    Tanaka N, Kimura H, Hoshino Y, Nishikawa K, Kojima S, Morishima T.

    Arch Virol   Vol. 147 ( 12 ) page: 2405-2417   2002

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  201. Monitoring of active HHV-6 infection in bone marrow transplant recipients by real time PCR; comparison to detection of viral DNA in plasma by qualitative PCR. Reviewed

    Ihira M, Yoshikawa T, Suzuki K, Ohashi M, Suga S, Horibe K, Tanaka N, Kimura H, Kojima S, Kato K, Matsuyama T, Nishiyama Y, Asano Y.

    Microbiol Immunol   Vol. 46   page: 701-705   2002

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  202. Decreasing the Epstein-Barr virus load by adjusting the FK506 blood level. Reviewed

    Orii T, Ohkohchi N, Satomi S, Hoshino Y, Kimura H.

    Transpl Int   Vol. 15   page: 529-534   2002

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  203. Diagnostic testing in Epstein-Barr virus infection. Reviewed

    Kudo T, Egawa H, Kuzushima K, Kimura H, Morishima T, Ichiyama S.

    Clin Chem Lab Med   Vol. 39   page: 789-94   2001

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  204. Investigation of Varicella-Zoster Virus DNA in Lymphocyte Subpopulations by Quantitative PCR Assay. Reviewed

    Ito Y, Kimura H, Hara S, Kido S, Ozaki T, Nishiyama Y, Morishima T.

    Microbiol Immunol   Vol. 45   page: 267-269   2001

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  205. Impaired Cytotoxic T Lymphocyte Response to Epstein-Barr Virus-infected NK Cells in Patients with Severe Chronic Active EBV Infection. Reviewed

    Tsuge I, Morishima T, Morita M, Kimura H, Kuzushima K, Matsuoka H

    J Med Virol   Vol. 64   page: 141-148   2001

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  206. Vidarabine Therapy for Severe Chronic Active Epstein-Barr Virus Infection. Reviewed

    Kimura H, Morita M, Tsuge I, Hoshino Y, Tanaka N, Ito Y, Morishima T.

    Am J Pediatr Hematol Oncol   Vol. 23   page: 294-299   2001

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  207. Severe Hepatitis caused by Epstein-Barr Virus without infection of hepatocytes Reviewed

    Kimura H, Nagasaka T, Hoshino Y, Hayashi N, Tanaka N, Jing Lan Xu, Kuzushima K, Morishima T.

    Human pathology   Vol. 32   page: 757-762   2001

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  208. SH2D1A mutations in Japanese males with severe Epstein-barr virus associated illness. Reviewed

    Sumazaki R, Kanegane H, Osaki M, Fukushima T, Tsutida M, Matsukura H, Shinozaki K, Kimura H, Matsui A, Miyamwaki T.

    Blood.   Vol. 98   page: 1268-1270   2001

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  209. *Clinical and Virological Characteristics of Chronic Active Epstein-Barr Virus Infection. Reviewed

    Kimura H, Hoshino Y, Kanegane H, Tsuge I, Okamura T, Kawa K, Morishim T.

    Blood   Vol. 98   page: 280-286   2001

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  210. Prospective Monitoring of the Epstein-Barr virus DNA by a real-time quantitative PCR after allogeneic stem cell transplantation. Reviewed

    Hoshino Y, Kimura H, Tanaka N, Tsuge I, Kudo K, Horibe K, Kato K, Matsuyama T, Kikuta A, Kojima S, Morishima T.

    Br J Heamatol   Vol. 115   page: 105-111   2001

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  211. Efficient identification of HLA A*2402-restricted cytomegalovirus-specific CD8+ T cell epitopes by a computer algorithm and an enzyme-linked immunospot assay.

    Kuzushima K, Hayashi H, Kimura H, Tsurumi T.

    Blood   Vol. 98   page: 1872-1881   2001

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  212. Monitoring of four herpesviruses in unrelated cord blood transplantation. Reviewed

    Tanaka N, Kimura H, Hoshino Y, Yoshikawa T, Asano Y, Horibe K, Kojima S, Morishima T.

    Bone Marrow Transplant   Vol. 26   page: 1193-1197   2000

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  213. Large deletion of the X-linked lymphoproliferative disease gene detected by fluorescence in situ hybridization. Reviewed

    Honda K, Kanegane H, Eguchi M, Kimura H, Morishima T, Masaki K, Tosato G, Miyawaki T, Ishii E.

    Am J Hematol   Vol. 64   page: 128-132   2000

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  214. Early intervention in post-transplant lymphoproliferative disorders based on epstein-barr viral load. Reviewed

    Hoshino Y, Kimura H, Kuzushima K, Tsurumi T, Nemoto K, Kikuta A, Nishiyama Y, Kojima S, Matsuyama T, Morishima T.

    Bone Marrow Transplant   Vol. 26   page: 199-201   2000

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  215. Usefulness of quantitative real-time polymerase chain reaction in following up patients with Epstein-Barr virus infection after liver transplantation. Reviewed

    Orii T, Ohkohchi N, Kikuchi H, Koyamada N, Chubachi S, Satomi S, Kimura H, Hoshino Y, Morita M.

    Clin Transplant   Vol. 14   page: 308-317   2000

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  216. Longitudinal Dynamics of Epstein-Barr Virus-Specific Cytotoxic T Lymphocytes during Posttransplant Lymphoproliferative Disorder. Reviewed

    Kuzushima K, Kimura H, Hoshino Y, Yoshimi A, Tsuge I, Horibe K, Morishima T, Tsurumi T, Kojima S.

    J Infect Dis   Vol. 182   page: 937-940   2000

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  217. Real-time quantitative reverse transcription-polymerase chain reaction for the detection of AML1-MTG8 fusion transcripts in t(8;21)-positive acute myelogenous leukemia. Reviewed

    Kondo K, Kudo K, Kimura H, Inaba J, Kato K, Kojima S, Matsuyama T, Horibe K.

    Leukemia Research   Vol. 24   page: 951-956   2000

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  218. Comparison of quantitations of viral load in varicella and zoster. Reviewed

    Kimura H, Kido S, Ozaki T, Tanaka N, Ito Y, Williams RK, Morishima T.

    J Clin Microbiol   Vol. 38   page: 2447-2449   2000

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  219. Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir. Reviewed

    Ito Y, Kimura H, Yabuta Y, Ando Y, Murakami T, Shiomi M, Morishima T.

    Clin Infect Dis   Vol. 30   page: 185-187   2000

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  220. Quantitative analysis of cytomegalovirus load using a real-time PCR assay. Reviewed

    Tanaka N, Kimura H, Iida K, Saito Y, Tsuge I, Yoshimi A, Matsuyama T, Morishima T.

    J Med Virol   Vol. 60   page: 455-462   2000

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  221. Monitoring of Cell-Free Viral DNA in Primary Epstein-Barr virus infection. Reviewed

    Kimura H, Nishikawa K, Hoshino Y, Sofue A, Nishiyama Y, and Morishima T.

    Med Microbiol Immunol   Vol. 188   page: 197-202   2000

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  222. The prevalence of TT virus (TTV) infection and its relationship to hepatitis in children. Reviewed

    Iriyama M, Kimura H, Nishikawa K, Yoshioka K, Wakita T,Nishimura N, Shibata M, Ozaki T, Morishima T

    Med Microbiol Immunol   Vol. 188   page: 83-89   1999

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  223. *Quantitative analysis of the Epstein-Barr virus load using a real-time PCR assay. Reviewed

    J. Clin. Microbiol.   Vol. 37   page: 132-136   1999

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  224. Characterization of Epstein-Bar virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy; establishment of an IL-2-dependent NK-like cell line. Reviewed

    Tsuge I, Morishima T, Morita M, Kimura H, Kuzushima K, Matsuoka H.

    Clin Exp Immunol.   Vol. 115   page: 385-392   1999

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  225. CD4- and CD56-positive T-cell line, MTA, established from natural killer-like T-cell leukemia/lymphoma. Reviewed

    Emi N, Abe A, Kasai M, Kohno A, Tanimoto M, Kimura H, Kawashima K, Ito M, Mori N, Saito H.

    Int J Hematol   Vol. 69   page: 180-185   1999

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  226. Detection of influenza virus RNA by reverse transcription-PCR and proinflammatorycytokines in influenza-virus-associated encephalopathy. Reviewed

    Ito Y, Ichiyama T, Kimura H, Shibata M, Ishiwada N, Kuroki H, Furukawa S, Morishima T

    J Med Virol   Vol. 58   page: 420-425   1999

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  227. Prevalence of maternal cytomegalovirus (CMV) antibody and detection of CMV DNA in amniotic fluid. Reviewed

    Nishimura N, Kimura H, Yabuta Y, Tanaka N, Ito Y, Ishikawa K, Suzuki C, Morishima T.

    Microbiol Immunol   Vol. 43   page: 781-784   1999

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  228. Rapid determination of Epstein-Barr virus specific CD8+T cell frequencies by flow cytometry. Reviewed

    Kuzushima K, Hoshino Y, Fujii K, Yokoyama N, Fujita M, Kiyono T, Kimura H, Morishima T, Trurumi T.

    Blood   Vol. 94   page: 3094-3100   1999

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  229. Antigen-driven expansion and contraction of CD8+-activated T cells in primary EBV infection. Reviewed

    Hoshino Y, Morishima T, Kimura H, Nishikawa K, Tsurumi T, Kuzushima K.

    J Immunol   Vol. 163   page: 5735-5740   1999

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  230. Baculovirus expression, purification, and properties of VZV gE, gI, and the complex they form. Reviewed

    Kimura H, Straus SE, and Williams RK.

    J Infect Dis   Vol. 178   page: 513-515   1998

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  231. Recombinant Varicella-Zoster virus glycoprotein E and I : immunologic response and clearance of virus in a guinea pig model of chronic uveitis(共著) Reviewed

    Journal of Infectious Deseases   Vol. 178   page: 310   1998

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  232. Polymerase chain reaction-proven herpes simplex encephalitis in children. Reviewed

    Ito Y, Ando Y, Kimura H, Kuzushima K, Morishima T.

    Pediatr Infect Dis J   Vol. 17   page: 29-32   1998

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  233. Varicella-zoster virus glycoproteins E and I expressed in insect cells form a heterodimer that requires the N-terminal domain of glycoprotein I. Reviewed

    Kimura H, Straus SE, and Williams RK.

    Virology.   Vol. 233   page: 382-391   1997

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  234. Establishment of anti-Epstein-Barr virus (EBV) cellular immunity by adoptive transfer of virus-specific cytotoxic T lymphocytes from an HLA-matched sibling to a patient with severe chronic active EBV infection. Reviewed

    Kuzushima K, Yamamoto M, Kimura H, Ando T, Kudo T, Tsuge I, Morishima T.

    Clin Exp Immunol   Vol. 103   page: 192-198   1996

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  235. Epstein-Barr virus (EBV)-carrying and -expressing T-cell lines established from severe chronic active EBV infection. Reviewed

    Imai S, Sugiura M, Oikawa O, Koizumi S, Hirao M, Kimura H, Hayashibara H, Terai N, Tsutsumi H, Oda T, Chiba s, Osato T.

    Blood   Vol. 87   page: 1446-1457   1996

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  236. Detection and quantification of virus DNA in plasma of patients with Epstein-Barr virus-associated diseases. Reviewed

    Yamamoto M. Kimura H. Hironaka T. Hirai K. Hasegawa S. Kuzushima K. Shibata M. Morishima T.

    J Clin Microbiol   Vol. 33   page: 1765-1768   1995

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  237. Intact antigen presentation for Epstein-Barr virus (EBV)-specific CTL by a lynphoblastoid cell line established from a patient with severe chronic active EBV intection

    Medical Microbiology and Immunology   Vol. 184   page: 63   1995

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  238. T-cell receptor V α region usage in the cerebrospinal fluid of patients with mumps meningitis. Reviewed

    Kimura H, Ando Y, Shibata M, Abe T and Morishima T.

    J Med Virol   Vol. 41   page: 306-311   1993

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  239. Quantitative analysis of herpes simplex virus DNA in cerebrospinal fluid of children with herpes simplex encephalitis. Reviewed

    Ando Y, Kimura H, Miwata H, Kudo T, Shibata M and Morishima T.

    J Med Virol   Vol. 41   page: 170-173   1993

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  240. Serum amyloid A protein in acute viral infections. Reviewed

    Miwata H, Yamada T, Okada M, Kudo T, Kimura H and Morishima T.

    Arch Dis Child   Vol. 68   page: 210-214   1993

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  241. Relapse of Herpes simplex encephalitis in children. Reviewed

    Kimura H, Aso K, Kuzushima K, Hanada N, Shibata M and Morishima T.

    Pediatr   Vol. 89   page: 891-894   1992

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  242. Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. Reviewed

    Yoshikawa T, Nakashima T, Suga S, Asano Y, Yazaki T, Kimura H, Morishima T, Kondo K and Yamanishi K.

    Pediatr   Vol. 89   page: 888-890   1992

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  243. Quantitation of cytomegalovirus DNA in lung tissue of bone marrow transplant recipients. Reviewed

    Shibata M, Terashima M, Kimura H, Kuzushima K, Yoshida J, Horibe K, Morishima T.

    Hum Pathol   Vol. 23   page: 911-915   1992

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  244. Prophylactic oral acyclovir in outbreaks of primary herpes simplex virus type 1 Infection in a closed community. Reviewed

    Kuzushima K, Kudo T, Kimura H, Kido S, Hanada N, Shibata M, Nishikawa K and Morishima T.

    Pediatr   Vol. 89   page: 379-383   1992

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  245. Detction of viral DNA in neonatal herpes simplex virus infuctions: Frequent and prolonged presence in serum and cerebrospinal fluid. Reviewed

    Kimura H, Futamura M, Kito H, Ando T, Goto M, Kuzushima K, Shibata M, Morishima T.

    J Infect Dis   Vol. 164   page: 289-293   1991

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  246. Minus strand RNA of hepatitis C virus in liver tissues. Reviewed

    Shibata M, Takeda S, Kudo T, Kimura H, Kuzushima K, Morishima T, Nagai Y.

    J Hepatol   Vol. 13   page: 379-380   1991

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  247. The pathogenecity of ribonucleotide reductase-null mutant of herpes simplex virus type 1 in mice. Reviewed

    Yamada Y, Kimura H, Morishima T, Daikoku T, Maeno K, Nishiyama Y.

    J Infect Dis   Vol. 164   page: 1091-1097   1991

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  248. Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus type 1 and 2. Reviewed

    Nishiyama Y, Kimura H, Daikoku T.

    J Virol   Vol. 65   page: 4520-4524   1991

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  249. Clinical manifestations of primary herpes simplex Virus type I infection in a closed community. Reviewed

    Kuzushima K, Kimura H, Kino Y, Kido S, Hanada N, Shibata M, Morishima T.

    Pediatr   Vol. 87   page: 152-158   1991

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    Language:English   Publishing type:Research paper (scientific journal)  

  250. Human cytomegalovirus infection during childhood: Detection of viral DNA in peripheral blood by means of polymerase chain reaction. Reviewed

    Shibata M, Morishima T, Terashima T, Kimura H, Kuzushima K, Hanada N, Nishikawa K and Watanabe K.

    Med Microbiol Immunol   Vol. 179   page: 245-253   1990

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    Language:English   Publishing type:Research paper (scientific journal)  

  251. Detection and direct typing of herpes simplex virus by polymerase chain raction. Reviewed

    Kimura H, Shibata M, Kuzushima K, Nishiyama Y. Morishima T.

    Med Microbiol Immunol   Vol. 179   page: 177-184   1990

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  252. SHepatitis C viral sepuences in sera during the acute phase of infection. Reviewed

    hibata M, Kudo T, Kajiyama M, Takahashi T, Matsushima S, Kimura H, Kuzushima K, and Morishima T.

    Am J Med   Vol. 89   page: 830-832   1990

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    Language:English   Publishing type:Research paper (scientific journal)  

  253. Prophylactic oral acyclovir in outbreaks of primary herpes simplex virus 1 infection. Reviewed

    Kuzushima K, Kimura H, Shibata M, Nishikawa K, Morishima T.

    Lancet   Vol. 335   page: 1043   1990

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    Language:English   Publishing type:Research paper (scientific journal)  

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Books 5

  1. Epstein-Barr Virus-associated T/NK-cell Lymphoproliferative Diseases.

    Fujiwara S, Kimura H( Role: Joint editor)

    Frontiers Media  2019.9  ( ISBN:978-2-88963-032-5

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    Language:English Book type:Scholarly book

  2. Human Herpesviruses

    Kawaguchi Y, Mori Y, Kimura H( Role: Joint editor)

    Springer Nature Singapore Pte Ltd  2018.7  ( ISBN:9789811072291

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    Total pages:501   Language:English Book type:Scholarly book

    Other Link: https://www.amazon.co.jp/Herpesviruses-Advances-Experimental-Medicine-Biology-ebook/dp/B07DPG9CLN

  3. *EBV-positive T-cell and NK-cell lymphoproliferative diseases of childhood: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Jaffe ES, Harris NL, Stein H, et al., eds

    Quintanilla-Martinez L, Ko YH, Kimura H, Jaffe ES.( Role: Joint author)

    IARC Press, Lyon  2017.9  ( ISBN:978-92-832-4494-3

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    Language:English Book type:Scholarly book

  4. *EBV-positive T-cell lymphoproliferative disorders of childhood: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Jaffe ES, Harris NL, Stein H, et al., eds

    Quintanilla-Martinez L, Kimura H, Jaffe ES.( Role: Joint author)

    IARC Press, Lyon  2008 

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    Language:English

  5. Chronic Active Epstein-Barr Virus Infection; New Developments in Epstein-Barr Virus Research,

    Kimura H( Role: Joint author)

    Nova Science Publishers  2006.9  ( ISBN:1-59454-860-9

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    Language:English

Presentations 4

  1. Medical education during COVID-19 International conference

    Hiroshi Kimura

    4th Digital GAME Annual Meeting  2020.10.15 

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    Event date: 2021.10

    Language:English  

  2. 大学人として知っておくべきコロナウイルスのこと Invited

    木村 宏

    第5回 東海機構ポストコロナフォーラム・イン・ウェビナー 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  3. 慢性活動性EBウイルス感染症 Invited

    木村 宏

    第42回日本造血細胞移植学会総会 

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    Event date: 2020.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  4. Chronic Epstein-Barr virus lymphoproliferative disease Invited International conference

    Hiroshi Kimura

    12th Annual T-cell Lymphoma Forum  2020.2.1 

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    Event date: 2020.1 - 2020.2

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:La Jolla, CA   Country:United States  

Research Project for Joint Research, Competitive Funding, etc. 28

  1. 慢性活動性EBV感染症と類縁疾患の疾患レジストリ情報に基づいた診療ガイドライン改定

    2020.4 - 2022.3

    科学技術振興調整費 

    木村 宏

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    Grant type:Competitive

  2. 新規臨床データと革新的技術の融合で読み解くEBウイルス再活性化

    2017.8 - 2020.3

    感染症研究革新イニシアティブ(J-PRIDE) 

    村田貴之

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    Grant type:Competitive

  3. 慢性活動性EBウイルス感染症と類縁疾患の疾患レジストリと バイオバンクの構築

    2017.4 - 2020.3

    科学技術振興調整費 

    木村 宏

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    Grant type:Competitive

  4. オミクス解析技術と人工知能技術による難治性造血器疾患の病因解明と診断向上に貢献する解析基盤の開発

    2017.4 - 2020.3

    難治性疾患実用化研究事業 

    宮野悟

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    Grant type:Competitive

  5. マルチプレックスPCR法を用いた造血幹細胞移植後の重症ウイルス感染症早期診断法実用化研究

    2016.9 - 2017.3

    橋渡し研究加速ネットワーク 

    木村 宏

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    Grant type:Competitive

  6. 母子感染に対する母子保健体制構築と医療技術開発のための研究

    2016.4 - 2019.3

    成育疾患克服等研究事業 

    藤井知行

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    Grant type:Competitive

  7. 慢性活動性EBウイルス感染症とその類縁疾患に対する革新的治療薬を実現するための統合的研究体制の構築

    2015.4 - 2018.3

    難治性疾患実用化研究事業 

    伊藤嘉規

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    Grant type:Competitive

  8. 慢性活動性EBウイルス感染症とその類縁疾患に対する革新的治療薬を実現するための統合的研究体制の構築

    2015.4 - 2018.3

    難治性疾患実用化研究事業 

    藤原成悦

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    Grant type:Competitive

  9. 慢性活動性EBウイルス感染症とその類縁疾患に対する革新的治療薬を実現するための独創的開発基盤

    2014.7 - 2015.3

    科学技術振興調整費 

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    Grant type:Competitive

  10. 慢性活動性EBウイルス感染症とその類縁疾患の診療ガイドライン作成 と患者レジストリの構築

    2014.4 - 2017.3

    科学技術振興調整費 

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    Grant type:Competitive

  11. 母子感染の実態把握及び検査・治療に関する研究

    2013.8 - 2016.3

    科学技術振興調整費 

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    Grant type:Competitive

  12. 慢性活動性EBウイルス感染症の発症機構解明と新規治療法開発に関する研究

    2012.4 - 2014.3

    科学技術振興調整費 

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    Grant type:Competitive

  13. 小児期のウイルス性肝炎に対する治療法の標準化に関する研究

    2011.8 - 2013.3

    科学技術振興調整費 

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    Grant type:Competitive

  14. 多角的解析によるEBV発癌を抑制する新規薬剤開発と ワクチン開発

    2010.4 - 2013.3

    科学技術振興調整費 

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    Grant type:Competitive

  15. 臓器移植患者の予後およびQOLの向上のための真菌やウイルス感染症の予防・診断・治療に関する研究

    2009.4 - 2012.3

    科学技術振興調整費 

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    Grant type:Competitive

  16. B型肝炎の母子感染および水平感染の把握とワクチン戦略の再構築に関する研究

    2009.4 - 2012.3

    科学技術振興調整費 

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    Grant type:Competitive

  17. 慢性活動性EBV感染症の実態解明と診断法確立に関する研究

    2009.4 - 2012.3

    科学技術振興調整費 

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    Grant type:Competitive

  18. EBV研究用試薬に添付する標準物質の値付けに係る検討

    2008.4 - 2009.3

    企業からの受託研究 

  19. TaqManPCR法によるCMVおよびEBV測定アプリケーション(研究用)の性能評価試験

    2007.6

    企業からの受託研究 

  20. NK細胞腫瘍に対する東アジア多国間治療研究

    2007.4 - 2010.3

    科学技術振興調整費 

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    Grant type:Competitive

  21. インフルエンザ脳症の発症因子の解明とそれに基づく発症前診断方法の確立に関する研究

    2006.4 - 2007.3

    科学技術振興調整費 

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    Grant type:Competitive

  22. EBVおよびCMVのTaqManPCR法による研究用製品化の検討

    2006.4 - 2007.3

    企業からの受託研究 

  23. 7価肺炎球菌ワクチン(7vPnCV)第II相臨床試験

    2004.9 - 2006.3

    企業からの受託研究 

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    乳児に対する肺炎球菌ワクチンの臨床試験を行い、その安全性・有効性を検討した。

  24. インフルエンザ脳症の発症因子の解明と治療及び予防方法の確立に関する研究

    2004.4 - 2006.3

    科学技術振興調整費 

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    Grant type:Competitive

  25. BK-VJE追加接種のための臨床試験

    2004.4 - 2005.3

    企業からの受託研究 

  26. 血中チトクロムC測定試薬(EDO070)

    2003.10 - 2004.3

    企業からの受託研究 

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    インフルエンザ治療の試薬として血中チトクロムCの有用性を検討した

  27. サルモデルにおけるベクターの安全性・有効性の評価実験系の開発

    2000.4 - 2001.3

    科学技術振興調整費 

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    Grant type:Competitive

  28. インフルエンザ等の呼吸器感染症に関する研究

    1998.4 - 1999.3

    科学技術振興調整費 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 16

  1. 欠失EBVよるリンパ腫発生機構の解明

    2020.4 - 2023.3

    科学研究費補助金  基盤研究(B)

    木村 宏

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    Authorship:Principal investigator 

  2. ウイルスmiRNAが腫瘍原性に果たす役割の解明

    2019.4 - 2021.3

    科学研究費補助金  研究成果公開促進費 (研究成果公開発表)

    木村 宏

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    Authorship:Principal investigator 

  3. 統合的遺伝子解析を用いた慢性活動性EBウイルス感染症の発症の機構の解析

    2017.4 - 2020.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  4. 遠隔転移腫瘍に対する腫瘍溶解ウイルスを用いた新規治療法の開発

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)

    五島典

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    Authorship:Coinvestigator(s) 

  5. 造血幹細胞移植患者における生体内ウイルス集団(Virome)の解明

    2014.4 - 2016.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  6. EBV関連Tリンパ腫発生に関与する宿主遺伝子の同定と機能解析

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  7. 難治性腫瘍に対するHSV1 型アンプリコンシステムを用いた新規遺伝子治療の開発

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  8. 難治性EBウイルス感染症に対する免疫寛容を利用した細胞療法の確立

    2012.4 - 2014.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  9. 単純ヘルペスウイルスの増殖を制御する宿主因子の同定とその役割の解明

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Coinvestigator(s) 

  10. 新規に開発したEBV感染細胞同定法によるEBV関連疾患の診断および病態解析

    2009.4 - 2012.3

    科学研究費補助金  基盤研究(C)

    木村 宏

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    Authorship:Principal investigator 

  11. 小児における急性脳炎・脳症の病態・診断・治療に関する研究

    2008.4 - 2010.3

    科学研究費補助金  基盤研究(A)

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    Authorship:Coinvestigator(s) 

  12. 造血幹細胞・臓器移植後に発生する難治性ウイルス感染症の早期発見・予防法の確立

    2007.4 - 2008.3

    科学研究費補助金  基盤研究(C)

    木村 宏

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    Authorship:Principal investigator 

  13. 小児における急性脳炎・脳症の病態・診断・治療に関する研究

    2005.4 - 2007.3

    科学研究費補助金  基盤研究(A)

    岡山大学・森島恒雄

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    Authorship:Coinvestigator(s) 

  14. 低出生体重児における症候性サイトメガロウイルス感染症の実態調査と予防

    2004.4 - 2006.3

    科学研究費補助金  基盤研究(C)

    木村 宏

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    Authorship:Principal investigator 

  15. 造血幹細胞移植後の免疫不全状態における難治性ウイルス感染症における細胞療法の開発

    2002.4 - 2003.3

    科学研究費補助金  高度先進医療開発経費

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    Authorship:Coinvestigator(s) 

  16. 免疫不全状態におけるウイルス感染症の再活性化の病態解明と予防・治療

    2001.4 - 2003.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

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Industrial property rights 3

  1. 抗ウイルス薬

    佐藤好隆、木村 宏、渡辺崇広

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    Application no:第2017-250093号  Date applied:2017.12

    Country of applicant:Domestic  

  2. ウイルス感染細胞の検出・同定法及びキット

    木村 宏、西山幸廣

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    Application no:PCT/JP2009/001173(WO)  Date applied:2009

    Patent/Registration no:5429679  Date registered:2013.12 

    Country of applicant:Domestic  

  3. ウイルス検出用オリゴヌクレオチドセット、EBV、CMV及びHHV-6の分析方法及び検出キット

    木村 宏、西山幸廣、和田かおる、久保田直実

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    Application no:2006-157532  Date applied:2006.6

    Patent/Registration no:5205609  Date registered:2013.3 

    Country of applicant:Domestic  

 

Teaching Experience (On-campus) 4

  1. First Year Seminar B

    2020

  2. Microorganisms and Human

    2020

  3. Training for Medical Research

    2020

  4. Molecular Pathology

    2020