日本癌学会

日本遺伝子治療学会

日本術中画像情報学会   理事

Generation and measurement of low-temperature plasma for cancer therapy: a historical review

Ishikawa, K; Takeda, K; Yoshimura, S; Kondo, T; Tanaka, H; Toyokuni, S; Nakamura, K; Kajiyama, H; Mizuno, M; Hori, M

FREE RADICAL RESEARCH   Vol. 57 ( 3 ) page： 239 - 270   2023.3

Cancer-specific cytotoxicity of Ringer's acetate solution irradiated by cold atmospheric pressure plasma

Miron, C; Ishikawa, K; Kashiwagura, S; Suda, Y; Tanaka, H; Nakamura, K; Kajiyama, H; Toyokuni, S; Mizuno, M; Hori, M

FREE RADICAL RESEARCH   Vol. 57 ( 2 ) page： 91 - 104   2023.2

Cooperation of Poly(rC)-binding Proteins 1/2 and Glutathione in Ferroptosis Induced by Plasma-activated Ringer's Lactate

Zheng, H; Jiang, L; Lyu, QY; Akatsuka, S; Motooka, Y; Sekido, Y; Nakamura, K; Tanaka, H; Ishikawa, K; Kajiyama, H; Mizuno, M; Hori, M; Toyokuni, S

CANCER SCIENCE   Vol. 114   page： 749 - 749   2023.2

Cooperation of Poly(rC)-binding Proteins 1/2 and Glutathione in Ferroptosis Induced by Plasmaactivated Ringer's Lactate

Zheng, H; Jiang, L; Lyu, QY; Akatsuka, S; Motooka, Y; Sekido, Y; Nakamura, K; Tanaka, H; Ishikawa, K; Kajiyama, H; Mizuno, M; Hori, M; Toyokuni, S

CANCER SCIENCE   Vol. 114   page： 1340 - 1340   2023.2

Plasma activated Ringer's lactate solution

Tanaka, H; Mizuno, M; Ishikawa, K; Miron, C; Okazaki, Y; Toyokuni, S; Nakamura, K; Kajiyama, H; Hori, M

FREE RADICAL RESEARCH   Vol. 57 ( 1 ) page： 14 - 20   2023.1

Influence of background characteristics in responders of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence

Yamanishi, T; Ishizuka, O; Shimizu, S; Kobayashi, Y; Kinoshita, F; Yamamoto, T; Mizokami, A; Narimoto, K; Toriyama, K; Kamei, Y; Kuwatsuka, Y; Mizuno, M; Gotoh, M

LUTS-LOWER URINARY TRACT SYMPTOMS   Vol. 14 ( 4 ) page： 273 - 280   2022.7

Cytotoxicity of plasma-irradiated lactate solution produced under atmospheric airtight conditions and generation of the methyl amino group

Ito, D; Iwata, N; Ishikawa, K; Nakamura, K; Hashizume, H; Miron, C; Tanaka, H; Kajiyama, H; Toyokuni, S; Mizuno, M; Hori, M

APPLIED PHYSICS EXPRESS   Vol. 15 ( 5 )   2022.5

Enhancement of ethanol production and cell growth in budding yeast by direct irradiation of low-temperature plasma

Tanaka Hiromasa, Matsumura Shogo, Ishikawa Kenji, Hashizume Hiroshi, Ito Masafumi, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Ito Mikako, Ohno Kinji, Okazaki Yasumasa, Toyokuni Shinya, Mizuno Masaaki, Hori Masaru

JAPANESE JOURNAL OF APPLIED PHYSICS   Vol. 61 ( SA )   2022.1

Plasma-activated Ringer's lactate solution inhibits the cellular respiratory system in HeLa cells

Tanaka, H; Maeda, S; Nakamura, K; Hashizume, H; Ishikawa, K; Ito, M; Ohno, K; Mizuno, M; Motooka, Y; Okazaki, Y; Toyokuni, S; Kajiyama, H; Kikkawa, F; Hori, M

PLASMA PROCESSES AND POLYMERS   Vol. 18 ( 10 )   2021.10

Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified

Tanaka, H; Hosoi, Y; Ishikawa, K; Yoshitake, J; Shibata, T; Uchida, K; Hashizume, H; Mizuno, M; Okazaki, Y; Toyokuni, S; Nakamura, K; Kajiyama, H; Kikkawa, F; Hori, M

SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page： 18488   2021.9

Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy

Suzuki Toshihiko, Sato Yoshiaki, Kushida Yoshihiro, Tsuji Masahiro, Wakao Shohei, Ueda Kazuto, Imai Kenji, Iitani Yukako, Shimizu Shinobu, Hida Hideki, Temma Takashi, Saito Shigeyoshi, Iida Hidehiro, Mizuno Masaaki, Takahashi Yoshiyuki, Dezawa Mari, Borlongan Cesar V, Hayakawa Masahiro

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM   Vol. 41 ( 7 ) page： 1707 - 1720   2021.7

Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate

Jiang, L; Zheng, H; Lyu, QY; Hayashi, S; Sato, K; Sekido, Y; Nakamura, K; Tanaka, H; Ishikawa, K; Kajiyama, H; Mizuno, M; Hori, M; Toyokuni, S

REDOX BIOLOGY   Vol. 43   page： 101989   2021.7

Preclinical Verification of the Efficacy and Safety of Aqueous Plasma for Ovarian Cancer Therapy

Nakamura, K; Yoshikawa, N; Mizuno, Y; Ito, M; Tanaka, H; Mizuno, M; Toyokuni, S; Hori, M; Kikkawa, F; Kajiyama, H

CANCERS   Vol. 13 ( 5 )   2021.3

Improvement of yield and grain quality by periodic cold plasma treatment with rice plants in a paddy field Reviewed

Hashizume, H; Kitano, H; Mizuno, H; Abe, A; Yuasa, G; Tohno, S; Tanaka, H; Ishikawa, K; Matsumoto, S; Sakakibara, H; Nikawa, S; Maeshima, M; Mizuno, M; Hori, M

PLASMA PROCESSES AND POLYMERS   Vol. 18 ( 1 )   2021.1

Biological characterization of adipose-derived regenerative cells used for the treatment of stress urinary incontinence

Okabe, YT; Shimizu, S; Suetake, Y; Matsui-Hirai, H; Hasegawa, S; Takanari, K; Toriyama, K; Kamei, Y; Yamamoto, T; Mizuno, M; Gotoh, M

INTERNATIONAL JOURNAL OF UROLOGY   Vol. 28 ( 1 ) page： 115 - 124   2021.1

Cancer Treatments Using Low-Temperature Plasma

Tanaka, H; Mizuno, M; Ishikawa, K; Toyokuni, S; Kajiyama, H; Kikkawa, F; Hori, M

CURRENT MEDICINAL CHEMISTRY   Vol. 28 ( 41 ) page： 8549 - 8558   2021

Regenerative treatment for male stress urinary incontinence by periurethral injection of adipose-derived regenerative cells: Outcome of the ADRESU study

Gotoh, M; Shimizu, S; Yamamoto, T; Ishizuka, O; Yamanishi, T; Mizokami, A; Narimoto, K; Toriyama, K; Kamei, Y; Nakayama, S; Kuwatsuka, Y; Mizuno, M; Hirakawa, A

INTERNATIONAL JOURNAL OF UROLOGY   Vol. 27 ( 10 ) page： 859 - 865   2020.10

Adjusted multiple gases in the plasma flow induce differential antitumor potentials of plasma-activated solutions

Nakamura, K; Yoshikawa, N; Yoshihara, M; Ikeda, Y; Higashida, A; Niwa, A; Jindo, T; Tanaka, H; Ishikawa, K; Mizuno, M; Toyokuni, S; Hori, M; Kikkawa, F; Kajiyama, H

PLASMA PROCESSES AND POLYMERS   Vol. 17 ( 10 )   2020.10

Non-thermal plasma-activated lactate solution kills U251SP glioblastoma cells in an innate reductive manner with altered metabolism

Ishikawa, K; Hosoi, Y; Tanaka, H; Jiang, L; Toyokuni, S; Nakamura, K; Kajiyama, H; Kikkawa, F; Mizuno, M; Hori, M

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 688   page： 108414   2020.7

Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway

Yoshikawa, N; Liu, WT; Nakamura, K; Yoshida, K; Ikeda, Y; Tanaka, H; Mizuno, M; Toyokuni, S; Hori, M; Kikkawa, F; Kajiyama, H

SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page： 1614   2020.1

Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions

Tanaka, H; Mizuno, M; Katsumata, Y; Ishikawa, K; Kondo, H; Hashizume, H; Okazaki, Y; Toyokuni, S; Nakamura, K; Yoshikawa, N; Kajiyama, H; Kikkawa, F; Hori, M

SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page： 13657   2019.9

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

Iida Madoka, Sahashi Kentaro, Kondo Naohide, Nakatsuji Hideaki, Tohnai Genki, Tsutsumi Yutaka, Noda Seiya, Murakami Ayuka, Onodera Kazunari, Okada Yohei, Nakatochi Masahiro, Okabe Yuka Tsukagoshi, Shimizu Shinobu, Mizuno Masaaki, Adachi Hiroaki, Okano Hideyuki, Sobue Gen, Katsuno Masahisa

NATURE COMMUNICATIONS   Vol. 10 ( 1 ) page： 4262   2019.9

Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner

Sato, K; Shi, L; Ito, F; Ohara, Y; Motooka, Y; Tanaka, H; Mizuno, M; Hori, M; Hirayama, T; Hibi, H; Toyokuni, S

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 65 ( 1 ) page： 8 - 15   2019.7

Design of a Randomized Controlled Clinical Study of tissue-engineered osteogenic materials using bone marrow-derived mesenchymal cells for Maxillomandibular bone defects in Japan: the TEOM study protocol

Shimizu Shinobu, Tsuchiya Shuhei, Hirakawa Akihiro, Kato Katsuyoshi, Ando Masahiko, Mizuno Masaaki, Osugi Masashi, Okabe Kazuto, Katagiri Wataru, Hibi Hideharu

BMC ORAL HEALTH   Vol. 19   2019.4

Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells

Sakai Yoshio, Honda Masao, Matsui Shigeyuki, Komori Osamu, Murayama Toshinori, Fujiwara Tadami, Mizuno Masaaki, Imai Yasuhito, Yoshimura Kenichi, Nasti Alessandro, Wada Takashi, Iida Noriho, Kitahara Masaaki, Horii Rika, Toshikatsu Tamai, Nishikawa Masashi, Okafuji Hirofumi, Mizukoshi Eishiro, Yamashita Tatsuya, Yamashita Taro, Arai Kuniaki, Kitamura Kazuya, Kawaguchi Kazunori, Takatori Hajime, Shimakami Tetsuro, Terashima Takeshi, Hayashi Tomoyuki, Nio Kouki, Kaneko Shuichi

CANCER SCIENCE   Vol. 110 ( 4 ) page： 1364 - 1388   2019.4

Impact of Therapeutic Angiogenesis Using Autologous Bone Marrow-Derived Mononuclear Cells Implantation in Critical Limb Ischemia With Scleroderma - Subanalysis of the Long-Term Clinical Outcomes Survey -

Shoji Keisuke, Yanishi Kenji, Yoshimi Ryusuke, Hamada Naoki, Kondo Kazuhisa, Fujimoto Kazuteru, Nakajima Hideaki, Kuwahara Koichiro, Higashi Yukihito, Fukumoto Yoshihiro, Murohara Toyoaki, Matoba Satoaki, Hayashida Ryo, Shibata Rei, Murotani Kenta, Ando Masahiko, Mizuno Masaaki, Fujiwara Tadami, Kato Tamon, Kajikawa Masato, Ootsuka Masanori, Sasaki Kenichiro, Saito Yoshihiko, Fukumoto Shinya

CIRCULATION JOURNAL   Vol. 83 ( 3 ) page： 662 - 671   2019.3

Non-thermal plasma-activated medium modified metabolomic profiles in the glycolysis of U251SP glioblastoma

Kurake Naoyuki, Ishikawa Kenji, Tanaka Hiromasa, Hashizume Hiroshi, Nakamura Kae, Kajiyama Hiroaki, Toyokuni Shinya, Kikkawa Fumitaka, Mizuno Masaaki, Hori Masaru

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 662   page： 83 - 92   2019.2

Molecular mechanisms of non-thermal plasmainduced effects in cancer cells

Tanaka, H; Mizuno, M; Ishikawa, K; Toyokuni, S; Kajiyama, H; Kikkawa, F; Hori, M

BIOLOGICAL CHEMISTRY   Vol. 400 ( 1 ) page： 87 - 91   2019.1

Supermolecular drug challenge to overcome drug resistance in cancer cells

Onishi Yasuhiko, Eshita Yuki, Ji Rui-Cheng, Kobayashi Takashi, Onishi Masayasu, Mizuno Masaaki, Yoshida Jun, Kubota Naoji

DRUG DISCOVERY TODAY   Vol. 23 ( 8 ) page： 1556 - 1563   2018.8

Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan

Kondo Kazuhisa, Yanishi Kenji, Hayashida Ryo, Shintani Satoshi, Shibata Rei, Murotani Kenta, Ando Masahiko, Mizuno Masaaki, Fujiwara Tadami, Murohara Toyoaki, Matoba Satoaki

CIRCULATION JOURNAL   Vol. 82 ( 4 ) page： 1168 - 1178   2018.4

Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium

Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Utsumi Fumi, Kajiyama Hiroaki, Okazaki Yasumasa, Toyokuni Shinya, Akiyama Shinichi, Maruyama Shoichi, Kikkawa Fumitaka, Hori Masaru

IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES   Vol. 2 ( 2 ) page： 99-102   2018.3

Effect of Plasma-Activated Lactated Ringer's Solution on Pancreatic Cancer Cells In Vitro and In Vivo

Sato Yusuke, Yamada Suguru, Takeda Shigeomi, Hattori Norifumi, Nakamura Kae, Tanaka Hiromasa, Mizuno Masaaki, Hori Masaru, Kodera Yasuhiro

ANNALS OF SURGICAL ONCOLOGY   Vol. 25 ( 1 ) page： 299 - 307   2018.1

Crystallization of calcium oxalate dihydrate in a buffered calcium-containing glucose solution by irradiation with non-equilibrium atmospheric pressure plasma

Kurake Naoyuki, Tanaka Hiromasa, Ishikawa Kenji, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Mizuno Masaaki, Ikehara Yuzuru, Hori Masaru

JOURNAL OF APPLIED PHYSICS   Vol. 122 ( 14 )   2017.10

Design of a single-arm clinical trial of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence in Japan: the ADRESU study protocol

Shimizu Shinobu, Yamamoto Tokunori, Nakayama Shinobu, Hirakawa Akihiro, Kuwatsuka Yachiyo, Funahashi Yasuhito, Matsukawa Yoshihisa, Takanari Keisuke, Toriyama Kazuhiro, Kamei Yuzuru, Narimoto Kazutaka, Yamanishi Tomonori, Ishizuka Osamu, Mizuno Masaaki, Gotoh Momokazu

BMC UROLOGY   Vol. 17 ( 1 ) page： 89   2017.9

Novel Intraperitoneal Treatment With Non-Thermal Plasma-Activated Medium Inhibits Metastatic Potential of Ovarian Cancer Cells

Nakamura Kae, Peng Yang, Utsumi Fumi, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki

SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page： 6085   2017.7

Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy

Shi, L; Ito, F; Wang, Y; Okazaki, Y; Tanaka, H; Mizuno, M; Hori, M; Hirayama, T; Nagasawa, H; Richardson, DR; Toyokuni, S

FREE RADICAL BIOLOGY AND MEDICINE   Vol. 108   page： 904 - 917   2017.7

Intraperitoneal Administration of Plasma-Activated Medium: Proposal of a Novel Treatment Option for Peritoneal Metastasis From Gastric Cancer

Takeda Shigeomi, Yamada Suguru, Hattori Norifumi, Nakamura Kae, Tanaka Hiromasa, Kajiyama Hiroaki, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Fujii Tsutomu, Fujiwara Michitaka, Mizuno Masaaki, Hori Masaru, Kodera Yasuhiro

ANNALS OF SURGICAL ONCOLOGY   Vol. 24 ( 5 ) page： 1188 - 1194   2017.5

Effects of center dot OH and center dot NO radicals in the aqueous phase on H2O2 and NO2- generated in plasma-activated medium

Kurake Naoyuki, Tanaka Hiromasa, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Kajiyama Hiroaki, Kondo Takashi, Kikkawa Fumitaka, Mizuno Masaaki, Hori Masaru

JOURNAL OF PHYSICS D-APPLIED PHYSICS   Vol. 50 ( 15 )   2017.3

Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium. Reviewed

Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Mizuno M, Toyokuni S, Hori M, Kikkawa F.

Oncol Rep.     2016.4

Cell survival of glioblastoma grown in medium containing hydrogen peroxide and/or nitrite, or in plasma-activated medium. Reviewed

Kurake N, Tanaka H, Ishikawa K, Kondo T, Sekine M, Nakamura K, Kajiyama H, Kikkawa F, Mizuno M, Hori M.

Arch Biochem Biophys.     2016.1

Effectiveness of plasma treatment on pancreatic cancer cells. Reviewed

Hattori N, Yamada S, Torii K, Takeda S, Nakamura K, Tanaka H, Kajiyama H, Kanda M, Fujii T, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Mizuno M, Hori M, Kodera Y.

Int J Oncol.   Vol. 47   page： 1655-1662   2015.11

Plasma-Activated Solution: Mechanism of Action, Clinical Application, and Industrialization Reviewed

Tanaka H, Mizuno M, Toyokuni S, Maruyama S, Kodera Y, Kikkawa F, Hori M.

Fukuoka Igaku Zasshi.   Vol. 106   page： 71-76   2015.4

Medicinal facilities to B16F10 melanoma cells for distant metastasis control with a supramolecular complex by DEAE-dextran-MMA copolymer/paclitaxel. Reviewed

Eshita Y, Ji RC, Onishi M, Kobayashi T, Mizuno M, Yoshida J, Kubota N, Onishi Y.

Drug Deliv Transl Res.   Vol. 5   page： 38-50   2015.2

Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration. Reviewed

Ye F, Kaneko H, Nagasaka Y, Ijima R, Nakamura K, Nagaya M, Takayama K, Kajiyama H, Senga T, Tanaka H, Mizuno M, Kikkawa F, Hori M, Terasaki H.

Sci Rep.   Vol. 5   page： 7705   2015.1

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl-dextran-MMA graft copolymer and paclitaxel used as an artificial enzyme. Reviewed

Onishi Y, Eshita Y, Ji RC, Onishi M, Kobayashi T, Mizuno M, Yoshida J, Kubota N.

Beilstein J Nanotechnol.   Vol. ５   page： 2293-2307   2014.12

Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules. Reviewed

Okazaki Y, Wang Y, Tanaka H, Mizuno M, Nakamura K, Kajiyama H, Kano H, Uchida K, Kikkawa F, Hori M, Toyokuni S.

J Clin Biochem Nutr   Vol. 55   page： 207-15   2014.11

A new tumorsphere culture condition restores potentials of self-renewal and metastasis of primary neuroblastoma in a mouse neuroblastoma model. Reviewed

Cao D, Kishida S, Huang P, Mu P, Tsubota S, Mizuno M, Kadomatsu K.

PLoS One   Vol. 22 ( 9 ) page： e86813   2014.1

Effect of indirect nonequilibrium atmospheric pressure plasma on anti-proliferative activity against chronic chemo-resistant ovarian cancer cells in vitro and in vivo. Reviewed

Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Mizuno M, Ishikawa K, Kondo H, Kano H, Hori M, Kikkawa F

PLoS One.   Vol. 8 ( 12 ) page： e81576.   2013.12

Glioblastoma Brain Tumor Cells by Down-Regulating a Survival Signaling Molecule, AKT Kinase. Plasma Medicine Reviewed

Tanaka H., Mizuno M., Ishikawa K., Nakamura K., Kajiyama H., Kano H., Kikkawa F., and Hori M.

Plasma Medicine   Vol. 1   page： 265-277   2013

Glioblastoma Brain Tumor Cells by Down-Regulating a Survival Signaling Molecule, AKT Kinase. Reviewed

Tanaka H., Mizuno M., Ishikawa K., Nakamura K., Kajiyama H., Kano H., Kikkawa F., and Hori M.

Plasma Medicine   Vol. 1 ( 3 ) page： 265-277   2013

Significant induction of apoptosis in renal cell carcinoma cells transfected with cationic multilamellar liposomes containing the human interferon-β gene through activation of the intracellular type 1 interferon signal pathway. Reviewed

  Vol. 40   page： 1441-1446   2012

Integrated care through disease- oriented clinical care pathways: experience from Japan's regional health planning initiatives. Reviewed

Okamoto E, Miyamoto M, Hara K, Yoshida J, Muto M, Hirai A, Mizuno M, Nagata H, Yamakata D, Tanaka H.

Int J Integrated Care   Vol. 11   page： 23   2011.9

Mechanism of the Introduction of Exogenous Genes into Cultured CellsUsing DEAE-Dextran-MMA Graft Copolymer as a Non-Viral Gene Carrier.II. Its Thixotropy Property. Reviewed

  Vol. 2   page： 1-8   2011

Neurosurgical robotic system for brain tumor removal. Reviewed

Arata J, Tada Y, Kozuka H, Wada T, Saito Y, Ikedo N, Hayashi Y, Fujii M, Kajita Y, Mizuno M, Wakabayashi T, Yoshida J, Fujimoto H.

Int J Comput Assist Radiol Surg   Vol. 6   page： 375-385   2010

Development of a real-time tactile sensing system for brain tumor diagnosis. Reviewed

Tanaka Y, Yu Q, Doumoto K, Sano A, Hayashi Y, Fujii M, Kajita Y, Mizuno M, Wakabayashi T, Fujimoto H.

Int J Comput Assist Radiol Surg   Vol. ５   page： 359-367   2010

*Effect of sonoporation on cationic liposome-mediated IFNbeta gene therapy for metastatic hepatic tumors of murine colon cancer. Reviewed

Hayashi S, Mizuno M, Yoshida J, Nakao

Cancer Gene Ther.   Vol. 16 ( 8 ) page： 638-643   2009

ICTを用いた脳卒中連携医療支援システムの構築

水野正明、吉田　純

日本医師会雑誌   Vol. 138   page： 1369-1373   2009

一方向型地域医療連携におけるICTの利活用

水野正明、吉田　純

ITvision   Vol. 19   page： 38-39   2009

A phase I clinical trial of interferon-beta gene therapy for high-grade glioma: novel findings from gene expression profiling and autopsy. Reviewed

Wakabayashi T, Natsume A, Hashizume Y, Fujii M, Mizuno M, Yoshida J.

J Gene Med   Vol. 10 ( 4 ) page： 329-39   2008

A pilot study of human interferon beta gene therapy for patients with advanced melanoma by in vivo transduction using cationic liposomes. Reviewed

Matsumoto K, Kubo H, Murata H, Uhara H, Takata M, Shibata S, Yasue S, Sakakibara A, Tomita Y, Kageshita T, Kawakami Y, Mizuno M, Yoshida J, Saida T.

Jpn J Clin Oncol   Vol. 38 ( 12 ) page： 849-56   2008

ICTを基盤にした脳卒中連携医療の実際

水野正明、吉田　純

新医療   Vol. 35   page： 169-172   2008

ICTと地域連携パス

水野正明

地域リハビリテーション   Vol. 3   page： 230-231   2008

ICTと脳卒中連携医療

水野正明、吉田　純

治療   Vol. 90 ( 3 ) page： 914-920   2008

*Significant antitumor activity of cationic multilamellar liposomes containing human interferon-β gene in combination with 5-fluorouracil against human renal cell carcinoma. Reviewed

Yamamoto K, Mizutani Y, Nakanishi H, Fujiwara J, Ishida H, Toiyama D, Abe K, Hayashi I, Okada K, Kawauchi A, Mizuno M, Yoshida J, Miki T.

Int. J Oncol   Vol. 33   page： 565-571   2008

A Regional Health Information Exchange System for Stroke Care (Nagoya-RHIE)

Obayashi M. Kagawa M, Mizuno M, Yoshida J

IHIC   Vol. 3   page： 112   2008

*Inhibition of Aurora-B function increases formation of multinucleated cells in p53 gene deficient cells and enhances anti-tumor effect of temozolomide in human glioma cells Reviewed

Tsuno T, Natsume A, Katsumata S, Mizuno M, Fujita M, Osawa H, Nakahara N, Wakabayashi T, Satoh Y, Inagaki M, Yoshida J

J Neuro-Oncol   Vol. 83   page： 249-258   2007

Characteristics of DEAE-dextran-MMA graft copolymer as a nonviral gene carrier Reviewed

Onishi Y, Eshita Y, Murashita A, Mizuno M, Yoshida J

Nanomedicine   Vol. 3   page： 184-191   2007

Medical information network for neurosurgical diseases

Mizuno M, Yoshida J

No Shinkei Geka   Vol. 35   page： 185-191   2007

連携医療支援システム

水野正明、吉田　純

脳卒中リハビリテーション連携パス   Vol. 1   page： 60-64   2007

医療情報ネットワーク（急性期医療、回復期医療、維持期医療）

水野正明、吉田　純

脳神経外科   Vol. 35   page： 185-191   2007

EGFR mutations in patients with brain metastases from lung cancer: Association with the efficacy of gefitinib Reviewed

Shimato S, Mitsudomi T, Kosaka T, Yatabe Y, Wakabayashi T, Mizuno M, Nakahara N, Hatano H, Natsume A, Ishii D, Yoshida J

Neuro-Oncol   Vol. 8   page： 137-144   2006

*Combination of In Vivo Angiopoietin-1 Gene Transfer and Autologous Bone Marrow Cell Implantation for Functional Therapeutic Angiogenesis Reviewed

Kobayashi K, Kondo T, Inoue N, Aoki M, Mizuno M, Komori K, Yoshida J, Murohara T

Arterioscler Thromb Vasc Biol   Vol. 26   page： 1465-1472   2006

Gene therapy for malignant glioma Reviewed

Mizuno M, Yoshida J

Nippon Rinsho   Vol. 63   page： 469-475   2005

*IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide Reviewed

Natsume A, Ishii D, Wakabayashi T, Tsuno T, Hatano H, Mizuno M, Yoshida J

Cancer Res   Vol. 65   page： 7573-7579   2005

Susceptibility to exogenously added interferon-beta protein depends on intracellular interferon-beta mRNA level in human glioma cells Reviewed

Osawa H, Mizuno M. Hatano M, Nakahara N, Tsuno T, Kuno T, Endo M, Yoshida J

Cytokine   Vol. 32 ( 5 ) page： 240-245   2005

2-diethylaminoethyl (DEAE)-dextran-MMA Graft Copolymer for Non-Viral Gene Delivery Vector Reviewed

Onishi Y, Eshita Y, Murashita A, Mizuno M, Yoshida J

J Appl Polym Sci   Vol. 98   page： 9-14   2005

Susceptibility to exogenously added interferon-beta protein depends on intracellular interferon-beta mRNA level in human glioma cells Reviewed

Osawa H, Mizuno M. Hatano M, Nakahara N, Tsuno T, Kuno T, Endo M, Yoshida J

Cytokine   Vol. 32   page： 240-245   2005

Structure-based design of an agonistic peptide targeting Fas Reviewed

Yoshimori A, Takasawa R, Hayakawa A, Mizuno M, Yoshida J, Tanuma S

Apoptosis   Vol. 10   page： 323-329   2005

Brain metastases from apocrine carcinoma of the scalp: case report Reviewed

1. Shimato S, Wakabayashi T, Mizuno M, Nakahara N, Hatano H, Natsume A, Ishii D, Hasegawa Y, Hyodo I, Nagasaka T, Yoshida J

J Neuro-Oncol   Vol. 29   page： 1-5   2005

IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide. Reviewed

Natsume A, Ishii D, Wakabayashi T, Tsuno T, Hatano H, Mizuno M, Yoshida J

Cancer Res.   Vol. 65   page： 7573-7579   2005

Suicide gene therapy using adenovirus vector for human oral squamous carcinoma cell line in vitro. Reviewed

Yamamoto N, Hayashi Y, Kagami H, Fukui T, Fukuhara H, Tohnai I, Ueda M, Mizuno M, Yoshida J.

Nagoya J Med Sci   Vol. 35   page： 185-191   2005

Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes Reviewed

Yoshida J, Mizuno M, Fujii M, Kajita Y, Nakahara N, Hatano M, Saito R, Nobayashi M, Wakabayashi T

Hum Gene Ther   Vol. 15   page： 77-86   2004

Growth inhibition of human pancreatic cancer cells by human interferon-beta gene combined with gemcitabine Reviewed

Endou M, Mizuno M, Nagata T, Tsukada K, Nakahara N, Tsuno T, Osawa H, Kuno T, Fujita M, Hatano M, Yoshida J

Int J Mol Med   Vol. 10   page： 110-116   2004

Aurora-B dysfunction of multinucleated giant cells in glioma detected by site-specific phosphorylated antibodies. Reviewed

Fujita M, Mizuno M, Nagasaka T, Wakabayashi T, Maeda K, Ishii D, Arima T, Kawajiri A, Inagaki M, Yoshida J

J Neurosurg   Vol. 101   page： 1012-1017   2004

Interferon-beta gene therapy for cancer: basic research to clinical application. Reviewed

Yoshida J, Mizuno M, Wakabayashi T

Cancer Sci   Vol. 95   page： 858-865   2004

Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells Reviewed

Hatano M, Mizuno M, Yoshida J

J Neurosurg   Vol. 101   page： 119-127   2004

Vaccination with tumor cell lysate-pulsed dendritic cells augments the effect of IFN-beta gene therapy for malignant glioma in an experimental mouse intracranial glioma. Reviewed

Saito R, Mizuno M, Nakahara N, Tsuno T, Kumabe T, Yoshimoto T, Yoshida J

Int J Cancer   Vol. 111   page： 777-782   2004

Two different mechanisms of apoptosis resistance observed in interferon-beta induced apoptosis of human glioma cells Reviewed

Saito R, Mizuno M, Hatano M, Kumabe T, Yoshimoto T, Yoshida J

J Neuro-Oncol   Vol. 67   page： 273-280   2004

Morphological assessment of the development of multinucleated giant cells in glioma by using mitosis-specific phosphorylated antibodies Reviewed

Maeda K, Mizuno M, Wakabayashi T, Takasu S, Nagasaka T, Inagaki M, Yoshida J

J Neurosurg   Vol. 98   page： 854-859   2003

Cell death of human oral squamous cell carcinoma cell line induced by herpes simplex virus thymidine kinase gene and ganciclovir Reviewed

Nishikawa M, Hayashi Y, Yamamoto N, Fukui T, Fukuhara H, Mitsudo K, Tohnai I, Ueda M, Mizuno M, Yoshida J

Nagoya J Med Sci   Vol. 66   page： 129-137   2003

Clinical gene therapy for brain tumors. Liposomal delivery of anticancer molecule to glioma Reviewed

Yoshida J, Mizuno M

J Neuro-Oncol   Vol. 65   page： 261-267   2003

Radioimmunoscintigraphy of intracranial glioma xenograft with a technetium-99m- labeled mouse monoclonal antibody specifically recognizing type III mutant epidermal growth factor receptor.

Takasu S, Takahashi T, Okamoto S, Oriuchi N, Nakayashiki N, Okamoto K, Muramatsu H, Hayashi T, Nakahara N, Mizuno M, Wakabayashi T, Higuchi T, Endo K, Kozaki K, Miyaishi O, Saga S, Ueda R, Yoshida J, Yoshikawa K

J Neuro-Oncol   Vol. 63   page： 247-256   2003

Growth inhibition of subcutaneous mouse melanoma and induction of natural killer cells by liposome-mediated interferon-beta gene therapy Reviewed

Ryuke Y, Mizuno M, Natsume A, Suzuki O, Nobayashi M, Kageshita T, Matsumoto K, Saida T, Yoshida J

Melanoma Res   Vol. 13   page： 349-356   2003

Apoptotic DNA endonuclease (DNase-gamma) gene transfer induces cell death accompanying DNA fragmentation in human glioma cells Reviewed

Saito R, Mizuno M, Kumabe T, Yoshimoto T, Tanuma S, Yoshida J

J Neuro-Oncol   Vol. 63   page： 25-31   2003

Improvement of transduction efficiency of recombinant adenovirus vector conjugated with cationic liposome for human oral squamous cell carcinoma cell lines Reviewed

Fukuhara H, Hayashi Y, Yamamoto N, Fukui T, Nishikawa M, Mitsudo K, Tohnai I, Ueda M, Mizuno M, Yoshida J

Oral Oncol   Vol. 39   page： 601-609   2003

Brain tumors Reviewed

Hatano M, Mizuno M, Yoshida J

Gan To Kagaku Ryoho   Vol. 30   page： 455-459   2003

Caspase activation in neuronal and glial apoptosis following spinal cord injury in mice Reviewed

Takagi T, Takayasu M, Mizuno M, Yoshimoto M, Yoshida J

Neurol Med Chir   Vol. 43   page： 20-29   2003

Processof apoptosis induced by TNF-α in murine fibroblast Ltk- cell: Continuous observation with video enhanced contrast microscopy Reviewed

Okamoto K, Mizuno M, Nakahara N, Natsume A, Yoshida J, Mori T, Hori S, Kobayashi H

Apoptosis   Vol. 7   page： 77-86   2002

Dendritic cells pulsed with tumor extract-cationic liposomes complex increase the induction of cytotoxic T lymphocytes in mouse brain tumor Reviewed

Aoki H, Mizuno M, Natsume A, Tsugawa T, Tsujimura K, Takahashi T, Yoshida J

Cancer Immunol Immunother   Vol. 50   page： 463-468   2002

Antitumor Effect of an Experimental Intracranial Human Glioma by Adeno-associated Virus Vector Containing the Human Interferon-β Gene Reviewed

Yoshida J, Mizuno M, Nakahara N and Colosi P

Jpn J Cancer Res   Vol. 93   page： 223-228   2002

Cationic liposomes conjugation to recombinant adenoviral vectors containing herpes simplex virus thymidine kinase gene followed by ganciclovir treatment reduces viral antigenicity and maintains antitumor activity in mouse subcutaneous glioma model Reviewed

Mizuno M, Ryuke Y, Yoshida J

Cancer Gene Ther   Vol. 9   page： 825-829   2002

Rat glioma cell death induced by cationic liposome-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir treatment Reviewed

Yoshida T, Mizuno M, Taniguchi K, Nakayashiki N, Wakabayashi T, Yoshida J

J Surgical Oncol   Vol. 30   page： 1-7   2001

IFN-β gene therapy inducessystemic antitumor immunity against malignant glioma. Reviewed

Natsume A, Tsujimura K, Mizuno M, Takahashi T, and Yoshida J

J Neuro-oncol   Vol. 47   page： 117-124   2000

Cationic liposome conjugation to recombinant adenoviral vector reduces viral antigenicity Reviewed

Natsume A, Mizuno M, Ryuke Y, Yoshida J.

Jpn. J. Cancer Res   Vol. 91   page： 363-367   2000

Combined effects of Adeno-associated virus vector and a herpes simplex virus mutant as neoplastic therapy Reviewed

Kasuya H, Mizuno M, Yoshida J, Nishiyama Y, Nomoto S, Nakano A

  Vol. 74   page： 214-218   2000

Transduction Efficiency of Adenoviral Vectors Into Human Glioma Cells Increased By Association With Cationic Liposomes Reviewed

Ryuke Y, Mizuno M, Natsume A, and Yoshida J

Neurol Med Chir   Vol. 40   page： 256-260   2000

Antitumor effect and cellular immunity activation by murine interferon-β gene transfer against intracerebral glioma in mouse Reviewed

Natsume A., Mizuno M., Yoshida J.

Gene Therapy   Vol. 6   page： 1626-1633   1999

Inhibitation of nuclear factor-κB activation confers sensitivity to tumor necrosis factor-α by impairment of cell cycle progression in human glioma cells Reviewed

Otsuka G, Nagaya T, Saito K, Mizuno M, Yoshida J, Seo H,

Cancer Res   Vol. 59   page： 4446-4452   1999

Imumnohistochemical staining of DNA topoisomerase (]G0002[)α in human glinne.

Journal of Neurosurgery   Vol. 91   page： 477-482   1999

Synergism between mild hyperthermia and interferon-β gene expression

Cancer letters   Vol. 139   page： 153-158   1999

Adeno-associated virus vectors containing the herpes simplex virus-thymidine kinase gene cause complete regression of intracerebrally implanted human gliomas on mice

Jpn J Cancer Res   Vol. 89   page： 76-80   1998

Growth inhibition of experimental glioma by human interferon-β superinduced by cationic liposomes entrapping polyinosilic : polycytidilic acid

Neurol Med Chir(Tokyo)   Vol. 38   page： 469-474   1998

Effect of human interferon-β gene transfer upon human glioma transplanted into nude mouse brain involues induced natural killer cells

Cancer Immunology Immunotherapy   Vol. 47   page： 227-232   1998

Video-enhanced microscopic visualization of apoptotic cell death caused by anti-Fas antibody in living human glioma cells

Brain Tumor Pathol   Vol. 15   page： 19-21   1998

Gene therapy for brain tumors

Annual Review 97     page： 135-140   1997

Augmentation of anti-Fas antibody-mediated apoptosis on human glioma cells by liposomes associated with the antibody

J Neuro-Oncology   Vol. 35   page： 7-11   1997

Antitumor activity of recombinant human tumor necrosis factor-α(rH-TNFα)and liposome-entrapped rH-TNFα

Neurologica medico-chirurgica   Vol. 37   page： 719-722   1997

Enzyme immunoassay of glioma cell tenascin secretion and augmentation by tumor necrosis factor-α

Neurologica medico-chirurgica   Vol. 37   page： 392-398   1997

Tumor necrosis factor-α gene transfer augments anti-Fas antibody mediated apoptosis in human glioma cells

Jpn J Cancer Res   Vol. 8   page： 543-547   1996

Targeting therapy for malignant glioma by means of immunoliposomes

  Vol. 11   page： 385-391   1996

Repeated exposure to cationic immunoliposomes activates effective gene transfer to human glioma cells

Neurologia medico-chirurgica   Vol. 36   page： 141-144   1996

Gene therapy against an experimental glioma using adeno-associated virus vectors

Gene Therapy   Vol. 3   page： 957-964   1996

Cytolysis of malignant glioma cells by lymphokine-actirated killer cells combined with anti-CD3-antiglioma bifunctional antibody and tumor necrosis factor-α

J. Surgical Oncol.   Vol. 62   page： 177-182   1996

Modification of apoptosis induced by anti-Fas antibody in human glioma cells

Neuroimmunological research   Vol. 9   page： 153-157   1996

New approach for the treatment of medulloblastoma by transfection with glial fibrillary acidic protein gene

Surgical Oncol   Vol. 5   page： 69-75   1996

グリオ-マ細胞の増殖におけるサイトカインの関与;特に遺伝子導入により誘導されるヒト型インタ-フェロンの抗腫瘍効果について

  Vol. 8 ( 3 ) page： 95-98   1995

Development of Gene Therapy for Brain tumors

  Vol. 21   page： 356-358   1995

遺伝子治療DDSとしてのDNA/liposome

日本DDS学会誌   Vol. 44   page： 399-403   1995

Inhibition of hepatitis B virus replication by interferon-β produced in situ by gene delivery.

Environ Med   Vol. 39   page： 33-36   1995

Simple preparation and characterization of cationic liposomes associated with a monoclonal antibody against glioma-associated antigen (immunoliposomes).

J Liposome Res   Vol. 5   page： 981-995   1995

Growth inhibition of intracerebral rat glioma by transfection-induced human interferon-β

J Surgical Oncology   Vol. 55   page： 105-109   1995

Gene Therapy for Brain tumors (In vivo experiment)

    page： 191-194   1995

Reinforced cytotoxixity of lymphokine-activated killer cells toward glioma cells by transfection of the killer cells with the γ-interferon gene.

Jpn J Cancer Res   Vol. 86   page： 95-100   1995

Cytokine Gene Therapy for Brain Tumors

    page： 2709-2712   1995

Immunotherapy by LAK cells transfected with cytokine genes

  Vol. 28   page： 376-380   1994

Growth inhibition of subcutaneously transplanted human glioma by transfection-induced tumor necrosis factor-α and augmentation of the effect by γ-interferon.

J Neuro-Oncol   Vol. 22   page： 221-225   1994

Simple method to prepare cationic multulamellar liposomes for efficient transfection of human interferon-β gene to human glioma cells

J Neuro-Oncol   Vol. 19   page： 269-274   1994

Retroviral transfer of herpes simplex thymidine kinase gene into glioma cells causes targeting of gancyclovir cytotoxic effect.

Neurologia medico-chirurgica   Vol. 34   page： 339-344   1994

Liposomal transfection of human γ-interferon gene into human glioma cells and adoptive immunotherapy using lymphokine-activated killer cells.

J Neurosurg   Vol. 80   page： 510-514   1994

Gene Transfer by Liposomes

  Vol. 5   page： 457-460   1994

Transfection-induced tumor necrosis factor-α increases the susceptibility of human glioma cells to lysis by lymphokine-acctivated killer cells : continuous expression of intercellular adhesion molecule-1 on the glioma cells.

Jpn J Cancer Res   Vol. 85   page： 750-755   1994

悪性神経膠腫に対する遺伝子組換えヒト腫瘍壊死因子(PAC-4D)の前期第(]G0002[)相臨床試験

薬理と治療   Vol. 22 ( Suppl.9 ) page： 291-310   1994

Radioimmunolocalization of human brain tumor : Fundamental studies with indium-111 labeled monoclonal antibody G-22.

Brain Tumor Pathology   Vol. 11 ( 2 ) page： 177-180   1994

New therapy for brain tumors : Cytokine gene therapy

Clinical Neuroscience   Vol. 12   page： 682-683   1994

Interferon-β endogenously produced by intratumoral injection of cationic liposome-encapsulated gene : Cytocidal effect on glioma transplanted into mude mouse brain.

Biochem Mol Biol Int   Vol. 32   page： 167-172   1994

Reinforced cytotoxicity of lymphokine-activated killer cells toward glioma cells by transfection with the tumor necrosis facter-α gene.

J Neurosurg   Vol. 78   page： 252-256   1993

Alternation of tumor associated cell surface antigenic expression (G-22 related antigen) with cytokines in vitro and in vivo.

Neuroimmunological research (神経免疫研究)   Vol. 5   page： 120-122   1993

Tumor-specific binding of radiolabeled G-22 monoclonal antibody in glioma patients.

Neurologia medico-chirurgica (Tokyo)   Vol. 32   page： 125-129   1992

脳内出血による高次機能障害に対するCT誘導下定位的血腫除去術の有効性

社会保険医学雑誌   Vol. 32   page： 1-5   1992

サイトカインによる脳腫瘍関連抗原発現の変化

神経免疫研究   Vol. 5   page： 120-122   1992

悪性脳腫瘍に対するtargeting療法の開発

日本DDS学会誌   Vol. 25   page： 331-339   1992

悪性脳腫瘍に対するインタ-フェロン遺伝子療法の開発

脳神経外科   Vol. 20   page： 547-551   1992

脳腫瘍治療に於けるG-CSFの有効性

  Vol. 63   page： 490-491   1992

Cytotoxicity of human β-interferon produced human glioma cells transfected with its gene by means of liposomes.

Biocheistry inernational   Vol. 28   page： 1055-1061   1992

Effectiveness of interferon-β,ACNU,and radiation therapy in pediatric patients with brainstem glioma.

Neurologia medico-chirurgica (Tokyo)   Vol. 32   page： 942-946   1992

Growth inhibition of glioma cells by liposome-mediated cell transfection with tumor necrosis factor-α gene. Its enhancement by prior γ-interferon treatment.

Neurologia medico-chirurgica (Tokyo)   Vol. 32   page： 873-876   1992

Clinical effect of intra-arterial tumor necrosis factor-α for malignant glioma.

J Neurosurg   Vol. 77   page： 78-83   1992

ラット脳腫瘍移植モデルに対するTNF-α動注療法の検討、動物実験MRIによる検索

神経免疫研究   Vol. 5   page： 218-221   1992

脳腫瘍治療におけるG-CSFの有効性

  Vol. 6   page： 490-491   1992

Antitumor effect of endogenous human β-interferon on malignant glioma and augmentation of the effect by tumor necrosis factor-α.

J Clin Biochem Nutr   Vol. 12   page： 153-160   1992

Antitumor effect of liposomes conjugated with a monoclonal antibody

Current Therapy   Vol. 10   page： 84-88   1992

Cytotoxicity of human β-and γ-interferon produced simultaneously in glioma cells transfected with interferon genes.

J Clin Biochem Nutr   Vol. 13   page： 1-6   1992

モノクロ-ナル抗体結合リポソ-ムの抗腫瘍効果.

カレントテラピ-   Vol. 10 ( 6 ) page： 84-88   1992

G-CSFヒト悪性glioma細胞の増殖に及ぼす影響特にTNF-αの細胞増殖抑制効果の増強効果について

  Vol. 63   page： 429-430   1992

Section of human β-interferon into the cystic fluid f glioma transfected with the interferon gene.

J Clin Biochem Nutr   Vol. 11   page： .123-128   1991

rH-TNF-αの悪性脳腫瘍に対する動注療法:特にCTにおける経時的腫瘍造影効果の変化について

  Vol. 5   page： 478-482   1991

Superinduction of cytotoxic interferon-β in glioma cells.

Neurologia medico-chirurgica (Tokyo)   Vol. 31   page： 485-489   1991

Intracranial metastasis of a choroid plexus papilloma originating in the cerebellopontine angle region : A case report.

Surg Neurol   Vol. 36   page： 54-58   1991

¹¹¹In標識モノクロ-ナル抗体G-22による脳腫瘍の画像診断への応用

神経免疫研究   Vol. 4   page： 276-280   1991

Growth inhibition of glioma cells transfected with the human β-interferon gene by liposomes coupled with a monoclonal antibody. Reviewed

Mizuno M, Yoshida J, Sugita K, Inoue I, Seo H, Hayashi Y, Koshizaka T, Yagi K

Cancer Res   Vol. 50   page： 7826-7829   1990

悪性脳腫瘍に対するインタ-フェロン遺伝子療法

神経免疫研究   Vol. 3   page： 153-158   1990

Radioimaging of human glioma xenografts with ¹²³I labeled monoclonal antibody G-22 against glioma-associated antigen.

J Neuro-Oncol   Vol. 8   page： 221-229   1990

Glowth inhibition of glioma cells of diferent cell lines by human interferon-β produced in the cells transfected with its gene by means of lipsomes.

J Clin Biochem Nutr   Vol. 9   page： 73-77   1990

¹³¹I標識抗gliomaモノクロ-ナル抗体G-22の臨床応用:画像診断及びタ-ゲット療法の試み

神経免疫研究   Vol. 3   page： 119-122   1990

Glowth inhibition of glioma cells transfected with the human β-interferon gene by liposomes coupled with a monoclonal antibody.

Cancer Res   Vol. 50   page： 7826-7829   1990

両側性網膜芽細胞腫の治療15年後に発生した頭蓋内線維肉腫、Cisplatin,VP-16併用化学療法の有効性

脳神経外科   Vol. 17   page： 653-657   1989

ヒトglioma細胞におけるHuIFN-β,IFGF-(]G0002[)の合成分泌能

神経免疫研究   Vol. 2   page： 159-164   1989

CDDPとEtoposide併用療法が奏功した頭蓋内Germinoma2症例

癌と化学療法   Vol. 16   page： 3457-3460   1989