Updated on 2021/03/23

写真a

 
SUZUKI, Haruhiko
 
Organization
Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. Doctor of Medicine

Research Interests 3

  1. maintenance of immune homeostasis

  2. CD8+

  3. regulatory T cells

Research Areas 1

  1. Others / Others  / Immunology

Current Research Project and SDGs 5

  1. Study on T cells regulating Immune Response

  2. Studies on the development, function, and role of CD8+ regulatory T cells

  3. Study of identifying factors that support the survival of resting T cells

  4. Study on Mice Lacking β chain of the Interleukin-2 Receptor

  5. The role of Fas/FasL in total body

Research History 3

  1. Associate Professor, Nagoya University Graduate School of Medicine

    2007.4

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    Country:Japan

  2. 名古屋大学大学院医学系研究科 助教授

    2000.1

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    Country:Japan

  3. 名古屋大学医学部 講師

    1996.3 - 1999.12

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    Country:Japan

Education 2

  1. Nagasaki University   Graduate School, Division of Medicine   oncology

    - 1990

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    Country: Japan

  2. Nagoya University   Faculty of Medicine   Medicine

    - 1984

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    Country: Japan

Professional Memberships 4

  1. 日本免疫学会

  2. Japanese Society for Cell Death Research

    2009.4

  3. 日本癌学会

  4. 日本分子生物学会

 

Papers 100

  1. CD8+CD122+CD49dlow regulatory T cells maintain T cell homeostasis by killing activated T cells via Fas/FasL pathway-mediated cytotoxicity. Reviewed

    Akane K, Kojima S, Mak TW, Shiku H, Suzuki H

    Proceedings of the National Academy of Science, the United States of America   Vol. 113 ( 9 ) page: 2460-2465   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas

    PubMed

  2. TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells. Reviewed

    Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.

    Nature Immunology   Vol. 16 ( 10 ) page: 1069-1076   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ni.3237

  3. Acceleration of ileal pacemaker activity in mice lacking interleukin 10. Reviewed

    Shozib HB, Suzuki H, Iino S, Nakayama S.

    Inflamm Bowel Dis.   Vol. 19 ( 8 ) page: 1577-1585   2013.7

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  4. CD8+CD122+ regulatory T cells contain clonally expanded cells with identical CDR3 sequences of the T cell receptor β chain. Reviewed

    Okuno Y, Murakoshi A, Negita M, Akane K, Kojima S, Suzuki H.

    Immunology   Vol. 139 ( 3 ) page: 309-317   2013.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  5. Autophagic activity in thymus and liver during aging. Reviewed

    Uddin MN, Nishio N, Ito S, Suzuki H, Isobe KI.

    Age (Dordr)   Vol. 34 ( 1 ) page: 75-85   2012.2

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  6. Dextran sulphate sodium increases splenic Gr1+CD11b+ cells which accelerate recovery from colitis following intravenous transplantation. Reviewed

    Zhang R, Ito S, Nishio N, Cheng Z, Suzuki H, Isobe KI.

    Clin Exp Immunol,   Vol. 164 ( 3 ) page: 417-427   2011.6

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  7. Cladribine enhances apoptotic cell death in lung carcinoma cells over-expressing DNase γ. Reviewed

    Hayakawa A, Suzuki H, Kamei Y, Tanuma S, Magae J

    Biol Pharm Bull.   Vol. 34   page: 1001-1004   2011

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  8. Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells. Reviewed

    Cheng Z, Ito S, Nishio N, Xiao H, Zhang R, Suzuki H, Okawa Y, Murohara T, Isobe K

    J Mol Cell Biol   Vol. 3   page: 91-98   2011

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  9. Up-regulation of Gr1+CD11b+ population in spleen of dextrransulfate sodium administered mice works to repair colitis. Reviewed

    Zhang R, Ito S, Nishio N, Cheng Z, Suzuki H, Isobe K

    Inflamm Allergy Drug Targets   Vol. 10   page: 39-46   2011

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  10. Differentiation of induced pluripotent stem cells to thymic epithelial cells by phenotype. Reviewed

    Inami Y, Yoshikai T, Ito S, Nishio N, Suzuki H, Sakurai H, Isobe K-I

    Immunol Cell Biol   Vol. 89   page: 314-321   2011

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  11. CD8+CD122+ Regulatory T Cells and CD4+ Treg Cooperatively Prevent and Cure CD4+ cell-induced Colitis Reviewed

    Agustina Tri Endharti, Yusuke Okuno, Zhe Shi, Nobuaki Misawa, Shinya Toyokuni, Masafumi Ito, Ken-ichi Isobe, and Haruhiko Suzuki

    The Journal of Immunology   Vol. 186   page: 41-52   2011

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    DOI: 41-52

  12. GADD34 suppresses wound healing by upregulating expression of myosin IIA. Reviewed

    Tanaka C, Ito S, Nishio N, Kodera Y, Sakurai H, Suzuki H, Nakao A, Isobe K

    Transgenic Res   Vol. 19   page: 637-645   2010

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  13. Toxic effects of d-galactose on thymus and spleen that resemble aging. Reviewed

    Uddin MN, Nishio N, Ito S, Suzuki H, Isobe K

    J Immunotoxicol   Vol. 7   page: 165-173   2010

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  14. Intra-bone marrow bone marrow transplantation rejuvenates the B cell lineage in aged mice. Reviewed

    Hida D, Ishiguro N, Haneda M, Ishida Y, Suzuki H, Isobe K

    Immunol Cell Biol   Vol. 88   page: 87-94   2010

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  15. Antibodies to wounded tissue enhances cutaneous wound healing. Reviewed

    Nishio N, Ito S, Suzuki H, Isobe K

    Immunology   Vol. 128   page: 369-380   2009

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  16. アレルギー性脳炎を抑制するCD8+CD122+レギュラトリーT細胞 Invited

    鈴木治彦

    臨床免疫・アレルギー科   Vol. 51   page: 25-32   2009

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    Authorship:Lead author   Language:Japanese  

  17. *Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg. Reviewed

    Shi Z, Okuno Y, Rifa'i M, Endharti AT, Akane K, Isobe KI, Suzuki H

    Eur. J. Immunol.   Vol. 39   page: 2106-2119   2009

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  18. *Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis. Reviewed

    Lee YH, Ishida Y, Rifa'i M, Shi Z, Isobe K, Suzuki H

    J. Immunol.   Vol. 180   page: 825-832   2008

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  19. Are CD8+CD122+ cells regulatory T cells or memory T cells? Reviewed

    Suzuki H, Shi Z, Okuno Y, Isobe K.

    Hum. Immunol.   Vol. 69   page: 751-754   2008

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  20. CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-αβTCR interaction and become IL-10-producing active regulatory cells Reviewed

    Rifa'i M, Shi Z, Zhang SY, Lee YH, Shiku H, Isobe K, Suzuki H

    Int. Immunol.   Vol. 20   page: 937-947   2008

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  21. Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Reviewed

    Shi Z, Rifa'i M, Lee YH, Shiku H, Isobe K, Suzuki H

    Immunology   Vol. 124   page: 121-128   2008

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  22. CD8+CD122+制御性T細胞による免疫制御 Invited

    鈴木治彦

    医学のあゆみ   Vol. 220   page: 525-526   2007

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    Authorship:Lead author   Language:Japanese  

  23. CD8+制御性T細胞とその免疫制御における研究の動向 Invited

    鈴木治彦

    実験医学   Vol. 25   page: 2850-2855   2007

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  24. CD8+の制御性T細胞 Invited

    鈴木治彦

    炎症と免疫   Vol. 15   page: 23-28   2007

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  25. A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities. Reviewed

    Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I.

    FEBS Lett.   Vol. 580   page: 839-843   2006

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  26. CD8陽性CD122陽性制御性T細胞 Invited

    鈴木治彦

    感染・炎症・免疫   Vol. 36   page: 84-86   2006

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  27. CD8+CD122+制御性T細胞 Invited

    鈴木治彦

    実験医学増刊号   Vol. 24   page: 122-129   2006

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  28. CD8+CD122+レギュラトリーT細胞 Invited

    鈴木治彦

    臨床免疫・アレルギー科   Vol. 46   page: 533-540   2006

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  29. Galectin-1 supports survival of naïve T cells without promoting cell proliferation. Reviewed

    Endharti AT., Zhou YW., Nakashima I., and Suzuki H.

    Eur. J. Immunol.   Vol. 35   page: 86-97   2005

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  30. *CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-g production and proliferation of CD8+ T cells. Reviewed

    Endharti AT., Rifai M., Shi Z., Fukuoka Y., Nakahara Y., Kawamoto Y., Takeda K., Isobe K-I., and Suzuki H.

    J. Immunol.   Vol. 175   page: 7093-7097   2005

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  31. Redox control of catalytic activities of membrane-associated protein tyrosine kinases. Reviewed

    Nakashima I., Takeda K., Kawamoto Y., Okuno Y., Kato M., and Suzuki H.

    Arch. Biochem. Biophys.   Vol. 434   page: 3-10   2005

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  32. CD8+CD122+制御性T細胞の免疫ホメオスタシス維持における役割 Invited

    鈴木治彦

    Annual Review免疫2006     page: 174-181   2005

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  33. CD8+CD122+制御性T細胞のT細胞抑制機構とその役割 Invited

    鈴木治彦

    Molecular Medicine免疫2006     page: 170-177   2005

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  34. c-Kit targeting immunotherapy for hereditary melanoma in a mouse model. Reviewed

    Kato M., Takeda K., Kawamoto Y., Tsuzuki T., Hossain K., Tamakoshi A., Kunisada T., Kambayashi Y., Ogino K., Suzuki H., Takahashi M., and Nakashima I.

    Cancer Res.   Vol. 64   page: 801-806   2004

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  35. Evidence of a novel IL-2/15Rb-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells. Reviewed

    Kamimura D., Ueda N., Sawa Y., Hachida S., Atsumi T., Nakagawa T., Sawa S-I., Jin G-H., Suzuki H., Ishihara K., Murakami M., and Hirano T.

    J. Immunol.   Vol. 173   page: 6041-6049   2004

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  36. *Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis. Reviewed

    Rifa'i M., Kawamoto Y., Nakashima I., and Suzuki H.

    J. Exp. Med.   Vol. 200   page: 1123-1134   2004

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  37. Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism. Reviewed

    Tsuboi H, Hossain K, Akhand AA, Takeda K, Du J, Rifa'i M, Dai Y, Hayakawa A, Suzuki H, Nakashima I.

    J. Cell. Biochem.   Vol. 93   page: 162-172   2004

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  38. Inhibition of Fas-mediated apoptotic cell death of murine T lymphocytes in a mouse model of immunosenescence in linkage to deterioration in cell membrane raft function. Reviewed

    Yokoyama T, Du J, Kawamoto Y, Suzuki H, Nakashima I.

    Immunology   Vol. 112   page: 64-71   2004

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  39. Identification of RET autophosphorylation sites by mass spectrometry. Invited Reviewed

    59. Kawamoto Y., Takeda K., Okuno Y., Yamakawa Y., Ito Y., Taguchi R., Kato M., Suzuki H., Takahashi M., and Nakashima I.

    J. Biol. Chem.   Vol. 279   page: 14213-14224   2004

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  40. CD8+CD122+ regulatory T cells Invited

    Haruhiko Suzuki

      Vol. 42   page: 515-522   2004

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  41. Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation. Reviewed

    Hossain K., Akhand AA., Kawamoto Y., Du J., Takeda K., Wu J., Yoshihara M., Tsuboi H., Kato M., Suzuki H., and Nakashima I.

    Free Radic Biol Med.   Vol. 34   page: 598-606   2003

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  42. 4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions. Reviewed

    Nakashima I., Liu W., Akhand AA., Takeda K., Kawamoto Y., Kato M., and Suzuki H.

    Mol. Aspects Med.   Vol. 24   page: 231-238   2003

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  43. Murine lymph node-derived stromal cells effectively support survival but induce no activation/proliferation of peripheral resting T cells in vitro. Reviewed

    Zhou YW., Aritake S., Endharti AT., Wu J., Hayakawa A., Nakashima I., and Suzuki H.

    Immunology   Vol. 109   page: 496-503   2003

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  44. Involvement of MKK6 in TCRalpha-betaintCD69lo: a target population for apoptotic cell death in thymocytes. Reviewed

    Suzuki H., Wu J., Hossain K., Ohhata T., Du J., Akhand AA., Hayakawa A., Kimura H., Hagiwara M., and Nakashima I.

    FASEB J.   Vol. 17   page: 1538-1540   2003

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  45. Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal. Reviewed

    Liu W., Akhand AA., Takeda K., Kawamoto Y., Itoigawa M., Kato M., Suzuki H., Ishikawa N., and Nakashima I.

    Cell Death Differ.   Vol. 10   page: 772-781   2003

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  46. Involvement of MEKK1/ERK/P21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal. Reviewed

    Du J., Cai S., Suzuki H., Akhand AA., Ma X., Takagi Y., Miyata T., Nakashima I., and Nagase F.

    J Cell Biochem.   Vol. 88   page: 1235-1246   2003

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  47. Redox-linked signal transduction pathways for protein tyrosine kinase activation.

    Antioxid Redox Signal.   Vol. 4   page: 517-531   2002

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  48. Modes of activation of mitogen-activated protein kinases and their roles in cepharantine-induced apoptosis in human leukemia cells.

    Cell. Signal.   Vol. 14   page: 509-515   2002

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  49. Activation of caspase-8 is critical for sensitivity to cytotoxic anti-Fas antibody-induced apoptosis in human ovarian cancer cells.

    Apoptosis   Vol. 7   page: 107-113   2002

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  50. Evidence of both extra- and intracellular cysteine targets of protein modification for activation of RET kinase.

    Biochem Biophys Res Commun.   Vol. 292   page: 826-831   2002

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  51. Redox control of T-cell death.

    Antioxid Redox Signal.   Vol. 4   page: 353-356   2002

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  52. Redox-linked cell surface-oriented signaling for T-cell death.

    Antioxid Redox Signal.   Vol. 4   page: 445-454   2002

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  53. Glyoxal and methylglyoxal induce lyoxal and methyglyoxal induce aggergation and inactivation of ERK in human endothelial cells.

    Free Radic. Biol. Med.   Vol. 31   page: 1228-1235   2001

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  54. Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in humanendothelial cells.

    Free Radic. Biol. Med.   Vol. 31   page: 20-30   2001

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  55. Mice lacking interleukin-2 (IL-2)/IL-15 receptor b chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant.

    Infect. Immun.   Vol. 69   page: 1226-1229   2001

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  56. Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death.

    J. Cell. Biochem.   Vol. 81   page: 679-688   2001

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  57. Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation.

    Antioxid. Redox Signal.   Vol. 3   page: 473-482   2001

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  58. Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process.

    Free Radic. Biol. Med.   Vol. 31   page: 469-478   2001

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  59. Differential roles of cytokine receptors in the development of epidermal gd T cells.

    J. Immunol.   Vol. 167   page: 1929-1923   2001

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  60. Cepharanthine activates caspases and induces apoptosis in Jurkat and K562 human leukemia cell lines.

    J. Cell. Biochem.   Vol. 82   page: 200-214   2001

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  61. T-cell-immunity-based inhibitory effects of orally administered herbal medicine juzen-taiho-to on the growth of primarily developed melanocytic tumors in RET-transgenic mice.

    J. Invest. Dermatol.   Vol. 117   page: 694-701   2001

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  62. Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation.

    Mol. Cell. Biol.   Vol. 21   page: 6851-6858   2001

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  63. Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation.

    Antioxid. Redox Signal.   Vol. 2   page: 841-849   2000

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  64. Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosinekinases.

    Mol. Biol. Cell.   Vol. 11   page: 93-101   2000

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  65. 4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death.

    J. Cell Sci.   Vol. 113   page: 635-641   2000

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  66. A short peptide derived from the antisense homology box of Fas ligand induces apoptosis in anti-Fas antibody-insensitive human ovarian cancer cells.

    Apoptosis   Vol. 5   page: 37-41   2000

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  67. Methylglyoxal induces apoptosis in Jurkat leukemia T cells by activating c-Jun N-terminal kinase.

    J. Cell. Biochem.   Vol. 77   page: 333-344   2000

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  68. Mercuric chloride stimulates distinct signal transduction pathway for DNA synthesis in a T-cell line, CTLL-2.

    J. Cell. Biochem.   Vol. 78   page: 500-508   2000

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  69. A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus.

    Virology   Vol. 275   page: 57-66   2000

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  70. Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase.

    J. Immunol.   Vol. 165   page: 4290-4297   2000

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  71. Mapping of melanoma modifier loci in RET transgenic mice.

    Jpn. J. Cancer Res.   Vol. 91   page: 1142-1147   2000

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  72. *Normal regulatory a/b T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor b in vivo.

    J. Exp. Med.   Vol. 190   page: 1561-1572   1999

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  73. Mercuric chloride induces increases in both cytoplasmic and nuclear free calcium ions through a protein phosphorylation-linked mechanism.

    Free Radic Biol Med.   Vol. 26   page: 227-231   1999

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  74. Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines.

    Oncogene   Vol. 18   page: 837-842   1999

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  75. Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src.

    J. Cell. Biochem.   Vol. 72   page: 1-7   1999

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  76. Nitric oxide controls src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Tyr-416-linked mechanism.

    J. Biol. Chem.   Vol. 274   page: 25821-25826   1999

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  77. Functional dissection of the cytoplasmic subregions of the IL-2 receptor bc chain in primary lymphocyte populations.

    EMBO J.   Vol. 17   page: 6551-6557   1998

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  78. Requirement of the IL-2 receptor b chain for the development of Vg3 dendritic epidermal T cells.

    J. Invest. Dermatol.   Vol. 110   page: 961-965   1998

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  79. The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinases.

    Int. J. Oncol.   Vol. 12   page: 1321-1326   1998

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  80. nsgenic mouse model for skin malignant melanoma.

    Oncogene   Vol. 17   page: 1885-1888   1998

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  81. Level of HgCl2-mediated phosphorylation of intracellular proteins determines death of thymicT-lymphocytes with or without DNA fragmentation.

    J. Cell. Biochem.   Vol. 71   page: 243-253   1998

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  82. Abnormal development of intestinal intraepitherial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain

    The Journal of Experimental Medicine   Vol. 185 ( 3 ) page: 499   1997

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  83. Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 veceptor β chain deficient mice

    International Immunology   Vol. 9 ( 9 ) page: 1367   1997

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  84. Mice lacking the IL-2 receptor beta chain and the regulation of T cell activation

    Immunology Frontier   Vol. 7 ( 2 ) page: 95-98   1997

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  85. Differential sensitivities to hyperbaric oxygen of lymphocyte subpopulations of normal and autoimmune mice.

    Immunol. Lett.   Vol. 59   page: 79-84   1997

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  86. Role for IL-15/IL-15 receptor b-chain in natural killer 1.1+ T cell receptor-ab+ cell development.

    J. Immunol.   Vol. 159   page: 5931-5935   1997

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  87. Protein kinase Ca-mediated chronic signal transduction for immunosenescence.

    J. Immunol.   Vol. 159   page: 2082-2084   1997

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  88. Chemical events in signal transduction.

    Immunol. Today.   Vol. 18   page: 362   1997

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  89. Magnitude of protein tyrosine phosphorylation-linked signals determines growth versus death of thymic T lymphocytes.

    Eur. J. Immunol.   Vol. 27   page: 1254-1259   1997

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  90. Mice lacking interleukin-2 receptor β chain

    Experimental Medicine   Vol. 14 ( 3 ) page: 75   1996

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  91. T細胞の活性化とその制御-インターロイキン2受容体β鎖ノックアウトマウスを用いた解析

    現代医学   Vol. 44 ( 2 ) page: 357-363   1996

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  92. Mercuric chloride mediates a protein sulfhydryl modification-based pathway of signal transduction for activating Src kinase which is independent of the phosphorylation/dephosphorylation of a carboxyl terminal tyrosine.

    J. Cell. Biochem.   Vol. 63   page: 104-114   1996

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  93. Disorders in mice disrupted with IL-2 receptor β chain

    Clinical Immunology   Vol. 28   page: 711   1996

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    Language:Japanese  

  94. Evidence of a novel redox-linked activation mechanism for the Src kinase which is independent of tyrosine 527-mediated regulation.

    Oncogene   Vol. 13   page: 2615-2622   1996

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    Language:English  

  95. Deregulated T cell activation and autoimmunity in mice lacking Interleukin-2 receptor β

    Science   Vol. 268   page: 1472   1995

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    Language:English  

  96. A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1.

    Leukemia   Vol. 8   page: 236-244   1994

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    Language:English  

  97. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development.

    Cell   Vol. 75   page: 83-97   1993

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    Language:English  

  98. Preferential usage of JH2 in D-J joinings with DQ52 is determined by the primary DNA sequence and is largely dependent on recombination signal sequences

    European Journal of Immunology   Vol. 22   page: 2225   1992

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    Language:English  

  99. Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase).

    Eur. J. Immunol.   Vol. 22   page: 235-239   1992

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    Language:English  

  100. Preferential usage of JH2 in D-J joinings with DQ52 in murine lymphocytes

    International Immunology   Vol. 1 ( 6 ) page: 643   1989

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    Language:English  

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Books 1

  1. 免疫実験法ハンドブック

    中島 泉、黒澤良和、吉開泰信、安部 良、宮坂昌之、宮島 篤、長澤丘司、岡田則子、岡田秀親、鍔田武志、高濱洋介、田沼靖一、鈴木治彦、谷口 克、稲葉カヨ、村田茂穂、田中啓二、三宅健介、南野昌信、石川博通、滝口雅文、徳久剛史、坂口志文、田平 武、林 衆治、高橋利忠、武田湖州恵、川本善之、吉田友昭、長瀬文彦、吉川和宏、上田龍三、森 尚義、加藤昌志、葛島清隆、安居院高志、横地高志、宮田敏男、稲城玲子、岩本隆司、磯部健一、田口栄一、村松壽子、村松 喬、福田敏史、高橋雅英、田口 良、Akhand Md. Anwarul Azim、朝光かおり、岡本 尚、中西 守、杜 軍、加藤 道、小寺良尚、永田 真、松田 幹、中野喜和男、高松真二、河合慶親、大澤俊彦、内田浩二、灘野大太、高部圭司、川北一人、小林 猛、花井泰三、山根 隆、新海政重( Role: Joint author)

    名古屋大学出版会  2006 

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    Language:Japanese

Presentations 11

  1. Essential roles of CD8+CD122+ regulatory T cells (CD122Treg) in immune homeostasis and their application to disease. International conference

    The Healthcare Technology Development Center Mini Symposium 2007 

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    Event date: 2007.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  2. Essential roles of CD8+CD122+ regulatory T cells in immune homeostasis and their applicaton to disease International conference

    Keystone Symposia 

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    Event date: 2007.2

    Language:English   Presentation type:Oral presentation (invited, special)  

  3. CD8+CD122+制御性T細胞の発見からその応用研究に至るまで

    鈴木治彦

    日本歯周病学会 第35回「若手研究者の集い」 

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    Event date: 2006.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  4. The role of CD8Treg in maintaining immune homeostasis and their application to immune-based disorders. International conference

    RCAI-JSI International Symposium 

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    Event date: 2006.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  5. Essential roles of CD8+CD122+ regulatory T cells in immune homeostasis and their application to autoimmune disease. International conference

    International Symposium:Autoimmunity in Intractable Diseases: From Bench to Clinic 

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    Event date: 2005.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  6. CD8+細胞の活性を強く調節するCD8+CD122+制御性T細胞のがん免疫への関わり

    鈴木治彦 俵功 珠玖洋

    第64回日本癌学会学術総会 

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    Event date: 2005.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  7. Essential roles of CD8+CD122+ regulatory T cells in the maintenance of immune homeostasis.

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    Event date: 2004.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  8. Lethally Dangerous Activation of Normal CD8+ T Cells in the Absence of CD8+CD122+ Regulatory T Cells. International conference

    12th International Congress of Immunology 

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    Event date: 2004.7

    Language:English   Presentation type:Poster presentation  

  9. CD8+CD122+ regulatory T cells but not CD4+CD25+ T cells prevent the development of lethal phenotype in CD122-deficient mice. International conference

    12th International Congress of Immunology 

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    Event date: 2004.7

    Language:English   Presentation type:Poster presentation  

  10. CD8+CD122+ regulatory T cells control fatally dangerous CD8+CD122- cells. International conference

    Keystone Symposia 

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    Event date: 2004.3

    Language:English   Presentation type:Poster presentation  

  11. IL-2/IL-2受容体システムによる免疫応答の制御

    鈴木治彦

    Immunology New Wave in YOKOHAMA ‘96 

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    Event date: 1996.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 23

  1. Fas/FasLによる免疫記憶の制御

    2016.9

    ビジョナリーリサーチ助成 

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    Grant type:Competitive

  2. CD122の生体内全般における役割の解明 

    2016.8

    研究助成 

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    Grant type:Competitive

    CD122は IL-2受容体のβ鎖であり、その全身ノックアウトではCD4+Tregも失われCD8+Tregの真の働きはマスクされてしまい不明である。CD4あるいはCD8のノックアウトとCD122ノックアウトを組み合わせてダブルノックアウトマウスを作り、この問題に迫る。

  3. がん免疫でのCD8+制御性T細胞の関わりの検討

    2016.4

    研究開発費 

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    Grant type:Competitive

    本研究代表者が同定したCD8+制御性T細胞について、がん組織、細胞に対する免疫応答を抑える働きがあるか、あるとすればそのCD8+制御性T細胞を無力化することによって抗がん効果が現れるのか等を目標とした研究である。

  4. CD8+制御性T細胞の新たな研究展開とそれに基づいた創薬ターゲットの探索

    2012.4 - 2013.3

    フィージビリティ探索タイプ 

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    Grant type:Competitive

    CD8+CD122+制御性T細胞がIL-10による抑制で働くのではなく、Fas-FasL系を利用した細胞傷害によって制御を行っていることがわかってきた。また、同CD8+制御性T細胞について、より絞り込んだ細胞集団を示すマーカーと制御の分子機構について見直しを図り、創薬ターゲットを探す目的でその制御性T細胞TCRの遺伝子クローニングを行い、CDR3領域等を含めた塩基配列決定を行った。

  5. 多発性硬化症と炎症性腸疾患におけるCD8+制御性T細胞の病態への関与の解明

    2011.4 - 2015.3

    医学振興助成金 

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    Grant type:Competitive

  6. CD8+CD122+制御性T細胞が認識する抗原分子の同定とそれを基にした研究の展開

    2011.4 - 2014.3

    学術研究助成 

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    Grant type:Competitive

  7. CD8+制御性T細胞の炎症性腸疾患への応用

    2011.4 - 2013.3

    学術研究助成金 

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    Grant type:Competitive

  8. 自己免疫疾患の新たな治療薬ターゲットの探索

    2011.4 - 2012.3

    フィージビリティ探索タイプ 

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    Grant type:Competitive

  9. CD8+CD122+制御性T細胞のがん免疫への関わりの解明と同細胞を利用したがん治療法の開発

    2010.4 - 2011.3

    がんその他の悪性新生物研究助成 

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    Grant type:Competitive

  10. CD8+制御性T細胞とCD4+制御性T細胞との協調による免疫恒常性維持機構の解明

    2009.4 - 2012.3

    研究助成 

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    Grant type:Competitive

  11. CD8+CD122+制御性T細胞に選択的に発現する分子のExpression Cloning法による同定

    2009.4 - 2010.3

    助成金 

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    Grant type:Competitive

  12. CD8+制御性T細胞を利用した全身性エリテマトーデス(SLE)に対する新たな治療方法の開発

    2009.4 - 2010.3

    研究助成 

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    Grant type:Competitive

  13. CD8+CD122+制御性T細胞による免疫制御の分子機構

    2008.4 - 2010.3

    研究奨励 

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    Grant type:Competitive

  14. 造血幹細胞移植におけるCD8+制御性T細胞の動態と効果

    2008.4 - 2009.3

    研究助成 

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    Grant type:Competitive

  15. CD8+CD122+制御性T細胞を利用したがん免疫療法の開発

    2006

  16. CD8+CD122+制御性T細胞による骨髄移植後の免疫応答制御の試み

    2005.4 - 2007.3

    一般研究賞 

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    Grant type:Competitive

  17. 新たに同定された制御性T細胞の免疫制御における意義と制御機構の解明

    2004.4 - 2005.3

    研究助成 

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    Grant type:Competitive

  18. 成熟Tリンパ球の細胞死を抑制し、生存を維持するために必要な因子とその機構についての研究

    2001.4 - 2002.3

    研究奨励 

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    Grant type:Competitive

  19. インターロイキン−2受容体β鎖依存性にT細胞の活性化を制御する細胞の同定とその制御機構についての研究

    2000.4 - 2001.3

    研究助成 

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    Grant type:Competitive

  20. 活性化T細胞を増殖維持する因子についての研究

    1999.4 - 2000.3

    研究助成金 

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    Grant type:Competitive

  21. MAPKK6 (Mitogen Activated Protein Kinase Kinase6)ノックアウトマウスの作製とその解析

    1998.4 - 1999.3

    研究奨励 

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    Grant type:Competitive

  22. MAPKK6 (Mitogen Activated Protein Kinase Kinase6)ノックアウトマウスの作製とその解析

    1997.4 - 1998.3

    がんその他の悪性新生物研究助成 

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    Grant type:Competitive

  23. インターロイキン−2受容体を介さないT細胞増殖機構に関する研究

    1996.4 - 1997.3

    研究助成 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. 過敏性と炎症を映す消化管興奮連携の可視化

    Grant number:2619H03558  2019.4 - 2022.3

    科学研究費補助金  基盤研究(B)

    中山晋介

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    Authorship:Coinvestigator(s) 

  2. Fas/FasLと放射線ないしはGVHによる細胞傷害によって引き起こされる皮膚炎

    2014.4 - 2015.3

    科学研究費補助金  挑戦的萌芽研究

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    Authorship:Principal investigator 

    FasLを欠損するgldマウスの骨髄を、gldマウスの骨髄で再構築するという同系骨髄移植実験を行うとGVHD様の皮膚炎が必発で起こってくる。皮膚炎の発症にはいかなる因子が必要か、いかなる細胞が皮膚炎の発生を抑えているか、多くの異なったノックアウトマウスを用意し、その骨髄細胞とgldマウス骨髄細胞と混ぜ合わせてgldマウス骨髄を再構築するなどして検討追求した。

  3. CD8陽性制御性T細胞を利用した炎症性腸疾患治療へのアプローチ

    2008.10 - 2010.9

    科学研究費補助金 

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    Authorship:Principal investigator 

    マウスIBDモデルにおいてCD8+CD122+Tregが炎症の抑制に働くことを見いだした。

  4. CD8+CD122+制御性T細胞を利用したがん免疫療法の開発

    2006.4 - 2007.3

    科学研究費補助金  特定領域研究

    鈴木治彦

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    Authorship:Principal investigator 

    マウスの実験系において、CD8+CD122+制御性T細胞が抗腫瘍免疫応答をも制御していることがわかり、同制御性細胞の活性を抑えることががんの治療につながる可能性を見いだした。

  5. 新規制御性T細胞の自己免疫疾患への関わりの解明と同細胞の骨髄移植への適用

    2005.10 - 2007.9

    科学研究費補助金 

    鈴木治彦

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    Authorship:Principal investigator 

    同種異系統間の骨髄移植において、CD8+CD122+制御性T細胞が移植片拒絶や移植片対宿主反応を抑制する能力を持つことを、マウスの実験系によって見いだした。

 

Teaching Experience (On-campus) 1

  1. 臓器移植

    2020

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    移植免疫学

 

Social Contribution 1

  1. 生命科学文化推進機構

    Role(s):Editer, Planner, Organizing member

    2015.4

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    Audience: Researchesrs, General, Company

    Type:Seminar, workshop