Faculty Profiles - KOIKE, Teruhiko

Papers - KOIKE, Teruhiko

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EFFECT OF D-ALLULOSE ON INSULIN RESISTANCE AND ENDURANCE ABILITY: IS D-ALLULOSE AN EXERCISE MIMETIC?

Koike, T; Gou, Y; Liu, BY; Natsume, Y; Tsuzuki, T; Shahriar, K; Banno, R

INNOVATION IN AGING Vol. 8 page： 876 - 876 2024.12

Relationship Of Skeletal Muscle Oxidative Capacity With Intramyocellular And Extramyocellular Lipids In Young And Older Individuals

Yoshiko, A; Shiozawa, K; Niwa, S; Takahashi, H; Koike, T; Watanabe, K; Katayama, K; Akima, H

MEDICINE & SCIENCE IN SPORTS & EXERCISE Vol. 56 ( 10 ) page： 7 - 7 2024.10

Factors Related To Trunk Intramuscular Adipose Tissue Content - Comparison Of Younger And Older Men

Kitagawa Funa, Tanaka Noriko, Ogawa Madoka, Yoshiko Akito, Oshida Yoshiharu, Koike Teruhiko, Akima Hiroshi

MEDICINE & SCIENCE IN SPORTS & EXERCISE Vol. 54 ( 9 ) page： 530 - 530 2022.9

The Relationship Between Serum Igf-1 And Fat Deposition Of Thigh In Younger And Older Men

Ogawa Madoka, Tanaka Noriko, Yoshiko Akito, Oshida Yoshiharu, Koike Teruhiko, Akima Hiroshi

MEDICINE & SCIENCE IN SPORTS & EXERCISE Vol. 54 ( 9 ) page： 529 - 529 2022.9

Relationships Between Skeletal Muscle Lipids And Muscle Functional Performances In Older Individuals

Yoshiko Akito, Maeda Hisashi, Takahashi Hideyuki, Koike Teruhiko, Tanaka Noriko I., Akima Hiroshi

MEDICINE & SCIENCE IN SPORTS & EXERCISE Vol. 54 ( 9 ) page： 531 - 531 2022.9

Importance of skeletal muscle lipid levels for muscle function and physical function in older individuals

Yoshiko Akito, Maeda Hisashi, Takahashi Hideyuki, Koike Teruhiko, Tanaka Noriko, Akima Hiroshi

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM Vol. 47 ( 6 ) page： 649 - 658 2022.6

Combined effects of exercise training and D-allulose intake on endurance capacity in mice. International journal

Takamasa Tsuzuki, Ryo Suzuki, Risa Kajun, Takako Yamada, Tetsuo Iida, Bingyang Liu, Teruhiko Koike, Yukiyasu Toyoda, Takayuki Negishi, Kazunori Yukawa

Physiological reports Vol. 10 ( 9 ) page： e15297 2022.5

Language：Japanese Publishing type：Research paper (scientific journal)

This study investigated the combined effects of exercise training and D-allulose intake on endurance capacity in mice. Male C57BL/6J mice were fed either a control diet (Con) or a 3% D-allulose diet (Allu) and further divided into the sedentary (Sed) or exercise training (Ex) groups (Con-Sed, Con-Ex, Allu-Sed, Allu-Ex, respectively; n = 6-7/group). The mice in the Ex groups were trained on a motor-driven treadmill 5 days/week for 4 weeks (15-18 m/min, 60 min). After the exercise training period, all mice underwent an exhaustive running test to assess their endurance capacity. At 48 h after the running test, the mice in the Ex groups were subjected to run at 18 m/min for 60 min again. Then the gastrocnemius muscle and liver were sampled immediately after the exercise bout. The running time until exhaustion tended to be higher in the Allu-Ex than in the Con-Ex group (p = 0.08). The muscle glycogen content was significantly lower in the Con-Ex than in the Con-Sed group and was significantly higher in the Allu-Ex than in the Con-Ex group (p < 0.05). Moreover, exercise training increased the phosphorylation levels of adenosine monophosphate-activated protein kinase (AMPK) in the muscle and liver. The phosphorylation levels of acetyl coenzyme A carboxylase (ACC), a downstream of AMPK, in the muscle and liver were significantly higher in the Allu-Ex than in the Con-Sed group (p < 0.05), suggesting that the combination of exercise training and D-allulose might have activated the AMPK-ACC signaling pathway, which is associated with fatty acid oxidation in the muscle and liver. Taken together, our data suggested the combination of exercise training and D-allulose intake as an effective strategy to upregulate endurance capacity in mice. This may be associated with sparing glycogen content and enhancing activation of AMPK-ACC signaling in the skeletal muscle.

DOI： 10.14814/phy2.15297

Web of Science

PubMed

Contribution of skeletal muscle and serum lipids to muscle contraction induced by neuromuscular electrical stimulation in older individuals

Akito Yoshiko, Hisashi Maeda, Hideyuki Takahashi, Teruhiko Koike, Noriko Tanaka, Hiroshi Akima

Physiological Reports Vol. 10 ( 6 ) 2022.3

d-Allulose Improves Endurance and Recovery from Exhaustion in Male C57BL/6J Mice. International journal

Bingyang Liu, Yang Gou, Takamasa Tsuzuki, Takako Yamada, Tetsuo Iida, Sixian Wang, Ryoichi Banno, Yukiyasu Toyoda, Teruhiko Koike

Nutrients Vol. 14 ( 3 ) 2022.2

Language：Japanese Publishing type：Research paper (scientific journal)

d-Allulose, a rare sugar, improves glucose metabolism and has been proposed as a candidate calorie restriction mimetic. This study aimed to investigate the effects of d-allulose on aerobic performance and recovery from exhaustion and compared them with the effects of exercise training. Male C57BL/6J mice were subjected to exercise and allowed to run freely on a wheel. Aerobic performance was evaluated using a treadmill. Glucose metabolism was analyzed by an intraperitoneal glucose tolerance test (ipGTT). Skeletal muscle intracellular signaling was analyzed by Western blotting. Four weeks of daily oral administration of 3% d-allulose increased running distance and shortened recovery time as assessed by an endurance test. d-Allulose administration also increased the maximal aerobic speed (MAS), which was observed following treatment for >3 or 7 days. The improved performance was associated with lower blood lactate levels and increased liver glycogen levels. Although d-allulose did not change the overall glucose levels as determined by ipGTT, it decreased plasma insulin levels, indicating enhanced insulin sensitivity. Finally, d-allulose enhanced the phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase and the expression of peroxisome proliferator-activated receptor γ coactivator 1α. Our results indicate that d-allulose administration enhances endurance ability, reduces fatigue, and improves insulin sensitivity similarly to exercise training. d-Allulose administration may be a potential treatment option to alleviate obesity and enhance aerobic exercise performance.

DOI： 10.3390/nu14030404

Web of Science

PubMed

The Neural Correlates of Semantic and Grammatical Encoding During Sentence Production in a Second Language: Evidence From an fMRI Study Using Structural Priming

Nakagawa Eri, Koike Takahiko, Sumiya Motofumi, Shimada Koji, Makita Kai, Yoshida Haruyo, Yokokawa Hirokazu, Sadato Norihiro

FRONTIERS IN HUMAN NEUROSCIENCE Vol. 15 2022.1

Relationship between adiponectin and intramuscular fat content determined by ultrasonography in older adults

Maya Hioki, Nana Kanehira, Teruhiko Koike, Akira Saito, Kiyoshi Shimaoka, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima

PLOS ONE Vol. 17 ( 1 ) page： e0262271 - e0262271 2022.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Public Library of Science (PLoS)

Age-associated intramuscular adipose tissue (IntraMAT) deposition induces the development of insulin resistance and metabolic syndrome. However, the relationship between IntraMAT and biochemical parameters in older adults remains unclear. The purpose of this study, therefore, was to elucidate the relationship between adiponectin and echo intensity–estimated IntraMAT using ultrasonography in normal-weight older adults (men 9, women 13) and examine biochemical parameters. Blood tests were performed to determine fasting levels of glucose, insulin, hemoglobin A1c, total cholesterol (Total-C), high-density-lipoprotein cholesterol, low-density-lipoprotein cholesterol (LDL-C), free fatty acid, triglycerides (TGs), adiponectin, leptin, high-sensitivity C-reactive protein, and high-sensitivity tumor necrosis factor, and homoeostasis model assessment index of insulin resistance (HOMA-IR). Mean gray-scale echo intensity was calculated as the IntraMAT index of the vastus lateralis. Waist circumference was measured at the level of the navel as the visceral adipose tissue (VAT) index. Echo intensity was significantly inversely correlated with adiponectin or LDL-C, and that was significantly positively correlated with TG. Adiponectin level was inversely correlated with waist circumference. Partial correlation analysis with waist circumference as the control variable revealed that adiponectin was inversely correlated with echo intensity, independent of waist circumference, whereas no such correlation was observed after controlling for LDL-C and TG levels. When biochemical parameters were grouped in the principal component analysis, among men, Total-C, insulin, and HOMA-IR or hemoglobin A1c, and high-sensitivity tumor necrosis factor–alpha were grouped with the same distribution for factors 1 and 2. Among women, glucose, insulin, HOMA-IR, and Total-C or TGs were grouped with the same distribution for factors 1 and 2. These data suggest that adiponectin level is related to IntraMAT content, independent of VAT in normal-weight older adults. The dynamics of adiponectin might not be similar to those of other circulating biochemical parameters in older men and women.

DOI： 10.1371/journal.pone.0262271

Web of Science

Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis. International journal

Akihiro Ryuge, Tomoki Kosugi, Kayaho Maeda, Ryoichi Banno, Yang Gou, Kei Zaitsu, Takanori Ito, Yuka Sato, Akiyoshi Hirayama, Shoma Tsubota, Takashi Honda, Kazuki Nakajima, Tomoya Ozaki, Kunio Kondoh, Kazuo Takahashi, Noritoshi Kato, Takuji Ishimoto, Tomoyoshi Soga, Takahiko Nakagawa, Teruhiko Koike, Hiroshi Arima, Yukio Yuzawa, Yasuhiko Minokoshi, Shoichi Maruyama, Kenji Kadomatsu

JCI insight Vol. 6 ( 20 ) 2021.10

Language：Japanese Publishing type：Research paper (scientific journal)

Monocarboxylates, such as lactate and pyruvate, are precursors for biosynthetic pathways, including those for glucose, lipids, and amino acids via the tricarboxylic acid (TCA) cycle and adjacent metabolic networks. The transportation of monocarboxylates across the cellular membrane is performed primarily by monocarboxylate transporters (MCTs), the membrane localization and stabilization of which are facilitated by the transmembrane protein basigin (BSG). Here, we demonstrate that the MCT/BSG axis sits at a crucial intersection of cellular metabolism. Abolishment of MCT1 in the plasma membrane was achieved by Bsg depletion, which led to gluconeogenesis impairment via preventing the influx of lactate and pyruvate into the cell, consequently suppressing the TCA cycle. This net anaplerosis suppression was compensated in part by the increased utilization of glycogenic amino acids (e.g., alanine and glutamine) into the TCA cycle and by activated ketogenesis through fatty acid β-oxidation. Complementary to these observations, hyperglycemia and hepatic steatosis induced by a high-fat diet were ameliorated in Bsg-deficient mice. Furthermore, Bsg deficiency significantly improved insulin resistance induced by a high-fat diet. Taken together, the plasma membrane-selective modulation of lactate and pyruvate transport through BSG inhibition could potentiate metabolic flexibility to treat metabolic diseases.

DOI： 10.1172/jci.insight.142464

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PubMed

Relationship between physical activity time and intramuscular adipose tissue content of the thigh muscle groups of younger and older men

Ogawa Madoka, Tanaka Noriko, Yoshiko Akito, Oshida Yoshiharu, Koike Teruhiko, Akima Hiroshi

SCIENTIFIC REPORTS Vol. 11 ( 1 ) 2021.10

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats. International journal

Yang Gou, Bingyang Liu, Mengyao Cheng, Takako Yamada, Tetsuo Iida, Sixian Wang, Ryoichi Banno, Teruhiko Koike

Molecules (Basel, Switzerland) Vol. 26 ( 20 ) 2021.10

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: d-Allulose is a rare sugar with antiobesity and antidiabetic activities. However, its direct effect on insulin sensitivity and the underlying mechanism involved are unknown. OBJECTIVE: This study aimed to investigate the effect of d-allulose on high-fat diet (HFD)-induced insulin resistance using the hyperinsulinemic-euglycemic (HE)-clamp method and intramuscular signaling analysis. METHODS: Wistar rats were randomly divided into three dietary groups: chow diet, HFD with 5% cellulose (HFC), and HFD with 5% d-allulose (HFA). After four weeks of feeding, the insulin tolerance test (ITT), intraperitoneal glucose tolerance test (IPGTT), and HE-clamp study were performed. The levels of plasma leptin, adiponectin, and tumor necrosis factor (TNF)-α were measured using the enzyme-linked immunosorbent assay. We analyzed the levels of cell signaling pathway components in the skeletal muscle using Western blotting. RESULTS: d-allulose alleviated the increase in HFD-induced body weight and visceral fat and reduced the area under the curve as per ITT and IPGTT. d-Allulose increased the glucose infusion rate in the two-step HE-clamp test. Consistently, the insulin-induced phosphorylation of serine 307 in the insulin receptor substrate-1 and Akt and expression of glucose transporter 4 (Glut-4) in the muscle were higher in the HFA group than HFC group. Furthermore, d-allulose decreased plasma TNF-α concentration and insulin-induced phosphorylation of stress-activated protein kinase/Jun N-terminal kinase in the muscle and inhibited adiponectin secretion in HFD-fed rats. CONCLUSIONS: d-allulose improved HFD-induced insulin resistance in Wistar rats. The reduction of the proinflammatory cytokine production, amelioration of adiponectin secretion, and increase in insulin signaling and Glut-4 expression in the muscle contributed to this effect.

DOI： 10.3390/molecules26206310

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PubMed

Investigation of D-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats

Natsume Yukie, Yamada Takako, Iida Tetsuo, Ozaki Nobuaki, Gou Yang, Oshida Yoshiharu, Koike Teruhiko

HELIYON Vol. 7 ( 9 ) 2021.9

Effect of electromyostimulation on intramyocellular lipids of the vastus lateralis in older adults: a randomized controlled trial

Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Takahashi Hideyuki, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

BMC MUSCULOSKELETAL DISORDERS Vol. 22 ( 1 ) 2021.6

Effect of elbow joint angles on electromyographic activity versus force relationships of synergistic muscles of the triceps brachii

Akima Hiroshi, Maeda Hisashi, Koike Teruhiko, Ishida Koji

PLOS ONE Vol. 16 ( 6 ) 2021.6

Eicosapentaenoic acid enhances skeletal muscle hypertrophy without altering the protein anabolic signaling pathway. Reviewed

Siriguleng, T. Koike, Y. Natsume, H. Jiang, L. Mu, Y. Oshida

Physiol Res Vol. 70 ( 1 ) page： 55 - 65 2021.2

Comparison Of Fascicle Behaviors Between Superficial And Deeper Muscles Of Triceps Brachii During Isometric Contractions

Akima Hiroshi, Maeda Hisashi, Koike Teruhiko, Ishida Koji, Ando Ryosuke

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 52 ( 17 ) page： 946 - 946 2020.7

Comparison Of Fascicle Behaviors Between Superficial And Deeper Muscles Of Triceps Brachii During Isometric Contractions

Akima Hiroshi, Maeda Hisashi, Koike Teruhiko, Ishida Koji, Ando Ryosuke

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 52 ( 17 ) page： 946 - 946 2020.7

Age-related changes in muscle volume and intramuscular fat content in quadriceps femoris and hamstrings

Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

EXPERIMENTAL GERONTOLOGY Vol. 132 2020.4

Electromyostimulation Induced Changes In Intramyocellular Lipid Of Vastus Lateralis In Older Adults

Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Takahashi Hideyuki, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 51 ( 6 ) page： 717 - 717 2019.6

Electromyostimulation Induced Changes In Intramyocellular Lipid Of Vastus Lateralis In Older Adults

Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Takahashi Hideyuki, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 51 ( 6 ) page： 717 - 717 2019.6

Skeletal muscle oxidative capacity related to intramyocellular lipid in young but not in older individuals. International journal

Akito Yoshiko, Kana Shiozawa, Shiori Niwa, Hideyuki Takahashi, Teruhiko Koike, Kohei Watanabe, Keisho Katayama, Hiroshi Akima

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme Vol. 50 page： 1 - 9 2025.1

Language：English Publishing type：Research paper (scientific journal)

Skeletal muscles contain lipids inside and outside cells, namely intramyocellular lipids (IMCL) and extramyocellular lipids (EMCL), respectively; lipids have also been found to be interspersed between these muscles as adipose tissue, namely intermuscular adipose tissue (IMAT). Metabolized IMCL has been recognized as an important substrate for energy production and their metabolism is determined by the muscle oxidative capacity. Therefore, it has been speculated that muscle oxidative capacity is related to muscle lipid content. Excessive accumulation of EMCL and IMAT has been confirmed in older individuals, leading to metabolic disorders and a decline in muscle strength. However, whether EMCL and IMAT contribute to muscle lipid metabolism remains unknown. This study aimed to investigate whether muscle oxidative capacity is related to IMCL, EMCL, and IMAT in young and older individuals. A total of 18 young and 14 older individuals were included and their muscle oxidative capacity was assessed based on the recovery rate of muscle oxygen saturation after exercise, using near-infrared spectroscopy of the medial gastrocnemius. IMCL, EMCL, and IMAT were assessed using magnetic resonance spectroscopy and imaging. A relationship between muscle oxidative capacity and IMCL was confirmed in young (r = -0.47, P < 0.05) but not older individuals (r = 0.22, P = 0.45). Muscle oxidative capacity was not related to EMCL or IMAT in either young or older individuals. These results suggest that IMCL in young individuals can contribute to muscle lipid metabolism, but not EMCL and IMAT, and this relationship differs with aging.

DOI： 10.1139/apnm-2024-0272

Web of Science

PubMed

Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults. International journal

Akito Yoshiko, Kana Shiozawa, Shiori Niwa, Hideyuki Takahashi, Teruhiko Koike, Kohei Watanabe, Keisho Katayama, Hiroshi Akima

GeroScience Vol. 46 ( 1 ) page： 517 - 530 2024.2

Language：English Publishing type：Research paper (scientific journal)

Muscle function and exercise performance measures, such as muscle endurance capacity, maximal strength, chair stand score, gait speed, and Timed Up and Go score, are evaluated to diagnose sarcopenia and frailty in older individuals. Furthermore, intramuscular adipose tissue (IntraMAT) content increases with age. Skeletal muscle oxidative capacity determines muscle metabolism and maintains muscle performance. This study aimed to investigate the association of skeletal muscle oxidative capacity with muscle function, exercise performance, and IntraMAT content in older individuals. Thirteen older men and women participated in this study. Skeletal muscle oxidative capacity was assessed by the recovery speed of muscle oxygen saturation after exercise using near-infrared spectroscopy from the medial gastrocnemius. We assessed two muscle functions, peak torque and time to task failure, and four sarcopenia-related exercise performances: handgrip strength, gait speed, 30-s chair stand, and Timed Up and Go. The IntraMAT content was measured using axial magnetic resonance imaging. The results showed a relationship between skeletal muscle oxidative capacity and gait speed but not with muscle functions and other exercise performance measures. Skeletal muscle oxidative capacity was not related to IntraMAT content. Skeletal muscle oxidative capacity, which may be indicative of the capacity of muscle energy production in the mitochondria, is related to locomotive functions but not to other functional parameters or skeletal fat infiltration.

DOI： 10.1007/s11357-023-01043-6

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PubMed

Factors related to trunk intramuscular adipose tissue content - A comparison of younger and older men. Reviewed International journal

Funa Kitagawa, Madoka Ogawa, Akito Yoshiko, Yoshiharu Oshida, Teruhiko Koike, Hiroshi Akima, Noriko I Tanaka

Experimental gerontology Vol. 168 page： 111922 - 111922 2022.10

Language：English Publishing type：Research paper (scientific journal)

The present study investigated factors related to trunk intramuscular adipose tissue (IntraMAT) content in younger and older men. Twenty-three healthy younger (20 to 29 years) and 20 healthy older men (63 to 79 years) participated in this study. The trunk IntraMAT content was measured using magnetic resonance imaging at the height of the 3rd lumbar vertebra. In addition to blood properties and physical performance, dietary intake was assessed by a self-administered diet history questionnaire. The dietary intake status was quantified using the nutrient adequacy score for the intake of 10 selected nutrients by summing the number of items that met the criteria of dietary reference intakes for Japanese individuals. The results obtained revealed that the trunk IntraMAT content was significantly higher in the older group than in the younger group (p < 0.05). In the younger group, the trunk IntraMAT content significantly correlated with systolic and diastolic blood pressure and HbA1c (rs = 0.443 to 0.464, p < 0.05). In the older group, significant and negative correlations were observed between the trunk IntraMAT content and 5-m usual walking speed, handgrip strength, and nutrient adequacy scores (rs = -0.485 to -0.713, p < 0.05). These results indicate that factors associated with the trunk IntraMAT content differed in an age dependent manner. In the younger group, the trunk IntraMAT content correlated with the metabolic status such as blood pressure and HbA1c. In the older group, physical performance and the dietary intake status negatively correlated with the trunk IntraMAT content.

DOI： 10.1016/j.exger.2022.111922

Web of Science

PubMed

Eicosapentaenoic acid enhances skeletal muscle hypertrophy without altering the protein anabolic signaling pathway. Reviewed

Siriguleng, T. Koike, Y. Natsume, H. Jiang, L. Mu, Y. Oshida.

Physiol Res Vol. 17 ( 70(1) ) page： 55 - 65 2021.3

Comparison of fascicle behaviors between superficial and deeper muscles of triceps brachii during isometric contractions Reviewed

Hiroshi Akima, Hisashi Maeda, Teruhiko Koike, Koji Ishida, Ryosuke Ando

Journal of Electromyography and Kinesiology Vol. 54 page： 102452 - 102452 2020.10

Comparing intramuscular adipose tissue on T1-weighted and two-point Dixon images Reviewed International journal

Madoka Ogawa, Akito Yoshiko, Noriko Tanaka, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima

PLoS One Vol. 15 ( 4 ) 2020.4

Muscle deoxygenation and neuromuscular activation in synergistic muscles during intermittent exercise under hypoxic conditions. Reviewed

Yoshiko A, Katayama K, Ishida K, Ando R, Koike T, Oshida Y, Akima H

Scientific Reports Vol. 10 ( 1 ) 2020.1

HIGHER AND LOWER MUSCLE ECHO INTENSITY IN ELDERLY INDIVIDUALS IS DISTINGUISHED BY MUSCLE SIZE, PHYSICAL PERFORMANCE AND DAILY PHYSICAL ACTIVITY

Yoshiko Akito, Natsume Yukie, Makino Taeko, Hayashi Takahiro, Umegaki Hiroyuki, Yoshida Yasuko, Cheng Xian Wu, Kuzuya Masafumi, Ishida Koji, Koike Teruhiko, Oshida Yoshiharu, Akima Hiroshi

ULTRASOUND IN MEDICINE AND BIOLOGY Vol. 45 ( 9 ) page： 2372 - 2380 2019.9

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

This study was performed to identify factors that discriminate muscle echo intensity (EI) among parameters of body composition, physical function and daily physical activity in elderly individuals. A total of 209 men and women (73.7 +/- 2.8 y) were evaluated. EI was measured on ultrasonographic axial thigh muscle images. The participants were categorized into the low, mid and high EI groups. We measured the skeletal muscle mass index (SMI) and physical functions. The high EI group exhibited a significantly lower SMI, slower 5-m walking time and shorter 6-min walking distance than the low EI group and had a shorter moderate-intensity activity time than the mid EI group. As a result of the discriminant analysis, elderly individuals were categorized into EI groups by SMI, daily activity and physical function. The data indicate that morphologic and functional parameters and the daily activity level help to discriminate higher and lower muscle EI. (C) 2019 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

DOI： 10.1016/j.ultrasmedbio.2019.05.029

Web of Science

Twenty-four months’ resistance and endurance training improves muscle size and physical functions but not muscle quality in older adults requiring long-term care. Reviewed

Yoshiko A, Kaji T, Sugiyama H, Koike T, Oshida Y, Akima H

The Journal of Nutrition, Health & Aging Vol. 23 ( 6 ) page： 564 - 570 2019.6

Relationship between physical activity and intramyocellular lipid content is different between young and older adults

Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Takahashi Hideyuki, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY Vol. 119 ( 1 ) page： 113 - 122 2019.1

Effects of 10-week walking and walking with home-based resistance training on muscle quality, muscle size, and physical functional tests in healthy older individuals. Reviewed

Yoshiko A, Tomita A, Ando R, Ogawa M, Kondo S, Saito A, Tanaka N.I, Koike T, Oshida Y, Akima H

European Review of Aging and Physical Activity Vol. 15 ( 13 ) 2018.11

Effects of post-fracture non-weight-bearing immobilization on muscle atrophy, intramuscular and intermuscular adipose tissues in the thigh and calf Reviewed

Akito Yoshiko, Koun Yamauchi, Takayuki Kato, Koji Ishida, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima

Skeletal Radiology Vol. 47 ( 11 ) page： 1541 - 1549 2018.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Springer Verlag

Objective: Disuse and/or a non-weight-bearing condition changes muscle composition, with decreased skeletal muscle tissue and increased fat within (intramuscular adipose tissue, IntraMAT) and between (intermuscular adipose tissue, InterMAT) given muscles. Excessive adipose tissue contributes to dysfunctional and metabolically impaired muscle. How these adipose tissues change during orthopedic treatment (e.g., cast immobilization, daily use of crutches) is not well documented. This study aimed to quantify changes in IntraMAT, InterMAT, and thigh and calf muscle tissue during orthopedic treatment. Materials and methods: We studied 8 patients with fifth metatarsal bone or fibular fractures. The ankle joint involved underwent plaster casting for approximately 4 weeks, with crutches used during that time. Axial T1-weighted MRI at the mid-thigh and a 30% proximal site at the calf were obtained to measure IntraMAT and InterMAT cross-sectional areas (CSAs) and skeletal muscle tissue CSA before treatment and 4 weeks afterward. Results: Thigh and calf muscle tissue CSAs were significantly decreased from before to after treatment: thigh, 85.8 ± 7.6 to 77.1 ± 7.3 cm2
calf, 53.3 ± 5.5 to 48.9 ± 5.0 cm2 (p &lt
0.05). None of the IntraMAT or InterMAT changes was statistically significant. There was a relation between the percentage change of thigh IntraMAT CSA and muscle tissue CSA (rs = −0.86, p &lt
0.01). Conclusions: The 4 weeks of treatment primarily induced skeletal muscle atrophy with less of an effect on IntraMAT or InterMAT. There is a risk of increasing IntraMAT relatively by decreasing skeletal muscle tissue size during orthopedic treatment.

DOI： 10.1007/s00256-018-2985-6

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Scopus

Muscle quality characteristics of muscles in the thigh, upper arm and lower back in elderly men and women Reviewed

Akito Yoshiko, Takashi Kaji, Hiroki Sugiyama, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima

European Journal of Applied Physiology Vol. 118 ( 7 ) page： 1385 - 1395 2018.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Springer Verlag

Purpose: The ratio of fat within skeletal muscle is an important parameter that is indicative of muscle quality, and can be assessed using ultrasonography to measure echo intensity (EI). Muscle EI indicates muscle strength and risk of physical dysfunction
however, this observation was determined following examinations of only selected muscle. The purpose of this study was to investigate the EI characteristics of muscles in several regions in elderly men and women, using physical function tests and serum cholesterol levels. Methods: Twenty-two men and women (age 78 ± 8 years) participated in this study. The EIs were calculated from rectus femoris (RF), biceps femoris (BF) triceps brachii (TB) and multifidus (MF) using B-mode transverse ultrasound images. Seven functional tests (isometric knee-extension peak torque, functional reach, sit-to-stand, 5-m normal/maximal speed walking, handgrip strength and timed up-and-go) and blood lipid components including adipocytokines were measured in all participants. Results: A statistically significant correlation between EI of the RF, TB and BF was observed (r = 0.46–0.50, P &lt
0.05), but not between EI of the MF and that of other muscles. EI of muscles of the limbs, which was averaged EI for RF, TB and BF, was negatively correlated with leptin levels (adjusted R2 = 0.27, P &lt
0.01), and EI of the MF was correlated with muscle mass and performance in the timed up-and-go test (adjusted R2 = 0.61, P &lt
0.01). Conclusion: These results suggest that EI might be influenced by specific parameters depending on the location of the muscle.

DOI： 10.1007/s00421-018-3870-7

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Scopus

Effects Of 24 Months Resistance And Endurance Training On Muscle Quality, Quantity And Physical Functions In Elderly With Long-term Care

Yoshiko Akito, Kaji Takashi, Sugiyama Hiroki, Koike Teruhiko, Oshida Yoshiharu, Akima Hiroshi

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 50 ( 5 ) page： 209-209 2018.5

Blunted Sympathetic Vasomotor Outflow To Inspiratory Resistive Breathing During Exercise In Women Compared to Men

Katayama Keisho, Smith Joshua R., Goto Kanako, Shimizu Kaori, Saito Mitsuru, Ishida Koji, Koike Teruhiko, Iwase Satoshi, Harms Craig A.

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 50 ( 5 ) page： 284-285 2018.5

Blunted Sympathetic Vasomotor Outflow To Inspiratory Resistive Breathing During Exercise In Women Compared to Men

Katayama Keisho, Smith Joshua R, Goto Kanako, Shimizu Kaori, Saito Mitsuru, Ishida Koji, Koike Teruhiko, Iwase Satoshi, Harms Craig A

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 50 ( 5 ) page： 284-285 2018.5

Effects Of 24 Months Resistance And Endurance Training On Muscle Quality, Quantity And Physical Functions In Elderly With Long-term Care

Yoshiko Akito, Kaji Takashi, Sugiyama Hiroki, Koike Teruhiko, Oshida Yoshiharu, Akima Hiroshi

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 50 ( 5 ) page： 209-209 2018.5

Elevated sympathetic vasomotor outflow in response to increased inspiratory muscle activity during exercise is less in young women compared with men Reviewed

Keisho Katayama, Joshua R. Smith, Kanako Goto, Kaori Shimizu, Mitsuru Saito, Koji Ishida, Teruhiko Koike, Satoshi Iwase, Craig A. Harms

Experimental Physiology Vol. 103 ( 4 ) page： 570 - 580 2018.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Blackwell Publishing Ltd

New Findings: What is the central question of this study? Premenopausal women have an attenuated inspiratory muscle metaboreflex-induced increase in arterial blood pressure compared with men. It is unclear whether sympathetic vasomotor outflow during dynamic exercise with increased inspiratory muscle activation is less in young women than in men. What is the main finding and its importance? The magnitude of increased sympathetic vasomotor outflow during leg cycling with inspiratory resistance was smaller in women than in men. Less sympathetic vasomotor outflow with inspiratory muscle metaboreflex activation could be one of the mechanisms for the attenuated inspiratory muscle-induced metaboreflex during exercise in young women. Abstract: We compared changes in muscle sympathetic nerve activity (MSNA) and cardiovascular variables during leg cycle exercise with increased inspiratory muscle resistance in men and women. We hypothesized that sympathetic vasomotor outflow during exercise with increased inspiratory resistance would be attenuated in young women compared with age-matched men. Eight women and seven men completed the study. The subjects performed two 10 min exercise bouts at 40% peak oxygen uptake using a cycle ergometer in a semirecumbent position [spontaneous breathing for 5 min and voluntary hyperventilation with or without inspiratory resistive breathing for 5 min (breathing frequency 50 breaths min−1 with a 50% duty cycle
inspiratory resistance 30% of maximal inspiratory pressure)]. Mean arterial blood pressure (MAP) was acquired using finger photoplethysmography. The MSNA was recorded via microneurography of the right median nerve at the cubital fossa. During leg cycle exercise with inspiratory resistive breathing, MSNA burst frequency was increased, accompanied by an increase in MAP in both men and women. Women, compared with men, had less of an increase in MAP (women +22.8 ± 12.3 mmHg versus men +32.2 ± 5.4 mmHg
P &lt
0.05) and MSNA burst frequency (women +9.6 ± 2.9 bursts min−1 versus men +14.6 ± 6.4 bursts min−1
P &lt
0.05). These results suggest that the attenuated inspiratory muscle-induced metaboreflex during exercise in young women is attributable, in part, to a lesser sympathetic vasomotor outflow compared with men.

DOI： 10.1113/EP086817

Web of Science

Scopus

Effect of acupuncture at acupoint of Shenshu (BL 23) on the bones of ovariectomized rats Reviewed

Takeda Atsushi, Koike Teruhiko, Urata Shigeru, Ishida Torao, Oshida Yoshiharu

JOURNAL OF TRADITIONAL CHINESE MEDICINE Vol. 38 ( 1 ) page： 54-60 2018.2

Effect of Prior Chronic Aerobic Exercise on Overload-Induced Skeletal Muscle Hypertrophy in Mice

Siriguleng, Koike T, Natsume Y, Iwama S, Oshida Y

PHYSIOLOGICAL RESEARCH Vol. 67 ( 5 ) page： 765 - 775 2018

Effect of 12-month resistance and endurance training on quality, quantity, and function of skeletal muscle in older adults requiring long-term care Reviewed

Akito Yoshiko, Takashi Kaji, Hiroki Sugiyama, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima

EXPERIMENTAL GERONTOLOGY Vol. 98 page： 230 - 237 2017.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Older adults requiring long-term care will experience age-associated deterioration of the quality and quantity of skeletal muscle if no interventions are performed. Long-term training is considered a typical intervention method and is effective for improvement of both muscle quantity and physical function. However, how such training affects muscle quality [i.e., fat-to-muscle ratio as determined by echo intensity (EI)] in older adults requiring long-term care remains unclear. The purpose of this study was to investigate the effects of a 12-month physical training intervention on the quality and quantity of skeletal muscle, physical function, and blood chemistry in older adults requiring long-term care. Seventeen older adults requiring long-term care (Tr-group) and 15 healthy older adults (Cont-group) participated in this study. Patients in the Tr-group performed exercises consisting of resistance and endurance training once or twice a week for 12 months. The EI and muscle thickness of the thigh were calculated from the rectus femoris and biceps femoris using B-mode transverse ultrasound images. Physical functions (isometric knee extension peak torque, sit-to-stand test, 5-m normal/maximal speed walking, handgrip strength, and timed up and go test) and blood lipid components including adipocytokines were measured at three points, i.e. baseline and 6 and 12 months after. The thigh EI was significantly lower after 6 months of training than baseline, and it returned to the initial level after 12 months of training (baseline, 70.2 +/- 8.3 a.u.; 6 months, 64.1 +/- 11.2 a.u.; 12 months, 72.3 +/- 7.2 a.u.). The thigh muscle thickness, 5-m maximal speed walking, and knee extension torque were significantly improved after 12 months of training (P < 0.05). The blood chemistry parameters did not significantly change. These results demonstrate that a 12-month training intervention contributes to improvement of muscle quantity and function with tentative changes in muscle quality but has no effect on blood chemistry in older adults requiring long-term care. We conclude that this type of training has the potential to restore the muscle functional abilities of older adults requiring long-term care.

DOI： 10.1016/j.exger.2017.08.036

Web of Science

Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis Reviewed

Naoko Iwata, Shintaro Iwama, Yoshihisa Sugimura, Yoshinori Yasuda, Kohtaro Nakashima, Seiji Takeuchi, Daisuke Hagiwara, Yoshihiro Ito, Hidetaka Suga, Motomitsu Goto, Ryoichi Banno, Patrizio Caturegli, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Arima

PITUITARY Vol. 20 ( 3 ) page： 301 - 310 2017.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：SPRINGER

Purpose IgG4-related disease is a systemic inflammatory disease characterized by infiltration of IgG4-positive plasma cells into multiple organs, including the pituitary gland. Autoimmunity is thought to be involved in the pathogenesis of IgG4-related disease. The diagnosis of IgG4-related hypophysitis (IgG4-RH) is difficult because its clinical features, such as pituitary swelling and hypopituitarism, are similar to those of other pituitary diseases, including lymphocytic hypophysitis and sellar/suprasellar tumors. The presence and significance of anti-pituitary antibodies (APA) in IgG4-RH is unclear.
Methods In this case-control study, we used single indirect immunofluorescence on human pituitary substrates to assess the prevalence of serum APA in 17 patients with IgG4-RH, 8 control patients with other pituitary diseases (lymphocytic infundibulo-neurohypophysitis, 3; craniopharyngioma, 2; germinoma, 3), and 9 healthy subjects.We further analyzed the endocrine cells targeted by the antibodies using double indirect immunofluorescence.
Results APA were found in 5 of 17 patients with IgG4-RH (29%), and in none of the pituitary controls or healthy subjects. The endocrine cells targeted by the antibodies in the 5 IgG4-RH cases were exclusively corticotrophs. Antibodies were of the IgG1 subclass, rather than IgG4, in all 5 cases, suggesting that IgG4 is not directly involved in the pathogenesis. Finally, antibodies recognized pro-opiomelanocortin in 2 of the cases.
Conclusions Our study suggests that autoimmunity is involved in the pathogenesis of IgG4-RH and that corticotrophs are the main antigenic target, highlighting a possible new diagnostic marker for this condition.

DOI： 10.1007/s11102-016-0780-8

Web of Science

Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice. Reviewed International journal

Aiko Inoue, Xian Wu Cheng, Zhe Huang, Lina Hu, Ryosuke Kikuchi, Haiying Jiang, Limei Piao, Takeshi Sasaki, Kohji Itakura, Hongxian Wu, Guangxian Zhao, Yanna Lei, Guang Yang, Enbo Zhu, Xiang Li, Kohji Sato, Teruhiko Koike, Masafumi Kuzuya

Journal of cachexia, sarcopenia and muscle Vol. 8 ( 3 ) page： 370 - 385 2017.6

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

BACKGROUND: Exercise train (ET) stimulates muscle response in pathological conditions, including aging. The molecular mechanisms by which exercise improves impaired adiponectin/adiponectin receptor 1 (AdipoR1)-related muscle actions associated with aging are poorly understood. Here we observed that in a senescence-accelerated mouse prone 10 (SAMP10) model, long-term ET modulated muscle-regenerative actions. METHODS: 25-week-old male SAMP10 mice were randomly assigned to the control and the ET (45 min/time, 3/week) groups for 4 months. Mice that were maintained in a sedentary condition served controls. RESULTS: ET ameliorated aging-related muscle changes in microstructure, mitochondria, and performance. The amounts of proteins or mRNAs for p-AMPKα, p-Akt, p-ERK1/2, p-mTOR, Bcl-XL, p-FoxO3, peroxisome proliferators-activated receptor-γ coactivator, adiponectin receptor1 (adpoR1), and cytochrome c oxidase-IV, and the numbers of CD34+ /integrin-α7+ muscle stem cells (MuSCs) and proliferating cells in the muscles and bone-marrow were enhanced by ET, whereas the levels of p-GSK-3α and gp91phox proteins and apoptotic cells were reduced by ET. The ET also resulted in increased levels of plasma adiponectin and the numbers of bone-marrow (BM)-derived circulating CD34+ /integrin-α7+ MuSCs and their functions. Integrin-α7+ MuSCs of exercised mice had improved changes of those beneficial molecules. These ET-mediated aged muscle benefits were diminished by adiponectin and AdipoR1 blocking as well as AMPK inhibition. Finally, recombinant mouse adiponectin enhanced AMPK and mTOR phosphorylations in BM-derived integrin-α7+ cells. CONCLUSIONS: These findings suggest that ET can improve aging-related impairments of BM-derived MuSC regenerative capacity and muscle metabolic alterations via an AMPK-dependent mechanism that is mediated by an adiponectin/AdipoR1 axis in SAMP10 mice.

DOI： 10.1002/jcsm.12166

Web of Science

PubMed

Adiponectin Is Inversely Associated With Estimated Intramuscular Fat Index In Middle-aged And Elderly Adults

Maya Hioki, Nana Kanehira, Teruhiko Koike, Akira Saito, Kiyoshi Shimaoka, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 49 ( 5 ) page： 238 - 238 2017.5

Relationships of Muscle Quality among Back, Lower and Upper Limbs in Older Individuals Invited Reviewed

Akito Yoshiko, Takashi Kaji, Hiroki Sugiyama, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 49 ( 5 ) page： 239 - 239 2017.5

Three-dimensional comparison of intramuscular fat content between young and old adults Reviewed

Akito Yoshiko, Maya Hioki, Nana Kanehira, Kiyoshi Shimaoka, Teruhiko Koike, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima

BMC MEDICAL IMAGING Vol. 17 2017.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：BIOMED CENTRAL LTD

Background: Fat infiltration within skeletal muscle is known as intramuscular fat (IMF), which increases with aging. Studies have assessed IMF content, using the mid-thigh as a representative location. However, three-dimensional IMF distribution is not well understood. The aim of this study was to compare the IMF content in young and old adults by assessing its distribution along the length of the thigh.
Methods: Consecutive transaxial images of the right thighs in 15 young (age, 21.0 +/- 0.4) and 15 old (age, 70.7 +/- 3.8) were obtained by magnetic resonance imaging. We measured IMF cross-sectional area (CSA), skeletal muscle CSA and calculated volume-and CSA-based IMF content for the quadriceps femoris (QF), hamstring (HM) and adductor (AD). CSA-based calculations were performed at every 10% of femur length (Lf), with 0% Lf and 100% Lf indicating the proximal and distal ends of femur.
Results: IMF CSAs along the length of the thigh were similar in both age groups. In contrast, skeletal muscle CSAs in all three muscle groups were significantly lower in old adults than in young adults (variation: -15.2 to -1.6 cm(2), P < 0.05). Thus, in volume-based measurements, the older adults had higher IMF contents than the younger adults (9.5% to 14.3% vs. 4.8% to 8.6%, respectively; P < 0.05). However, such age-dependent differences were not observed at the mid-thigh in the QF and AD.
Conclusion: The results demonstrated an age-related increase in IMF content-confirmed in areas of the thigh-primarily based on finding lower amounts of skeletal muscle mass in CSAs in the older adults.

DOI： 10.1186/s12880-017-0185-9

Web of Science

Cathepsin K-mediated Notch 1 activation contributes to neovascularisation in response to hypoxia. Reviewed

41) H. Jiang, XW. Cheng, GP. Shi, L. Hu, A Inoue, Y. Yamamura, H. Wu, K. Takeshita, X. Li, Z. Huang, H. Song, M. Asai, C. Hao, K. Unno, T. Koike, Y. Oshida, K. Okumura, T. Murohara, M. Kuzuya.

Nat Commun Vol. 5 page： 3838. 2014.6

b-Hydroxy-b-methylbutyrate suppresses tumor necrosis factor-a/interferon-g-induced MuRF expression in C2C12 cells. Reviewed

K. Kimura, XW. Cheng, A. Inoue, L. Hu, T. Koike, M. Kuzuya

Nutr Res Vol. 34 page： 368-374 2014

Enhanced muscle pump during mild dynamic leg exercise inhibits sympathetic vasomotor outflow. Reviewed

K. Katayama, K. Ishida, M. Saito, T. Koike, A. Hirasawa, M. Saito.

Physiol Rep Vol. ２ page： e12070 2014

Hypoxic effects on sympathetic vasomotor outflow and blood pressure during exercise with inspiratory resistance. Reviewed

K. Katayama, S. Yamashita, K. Ishida, E. Iwamoto,T. Koike, M. Saito.

Am J Physiol Regul Integr Comp Physiol Vol. 304 ( 5 ) page： R374-R382 2013.3

Effects of angiotensin II AT1 receptor inhibition and exercise training on insulin action in rats on high-fat diet. Reviewed

Z. Wang , T. Koike, P. Li, H. Jiang , Y. Natsume , L. Mu , T. Chen , Y. Oshida.

Life Sciences Vol. 90 page： 322-327 2012

高果糖食負荷ラットでのインスリン作用に対するアロプリノールの影響

姜海英、小池晃彦、木蘭、夏目有紀枝、王忠華、成憲武、押田芳治

総合保健体育科学 Vol. 35 ( 1 ) page： 23-27 2012

健康教室に参加する一般高齢者のヘルスリテラシーと運動能力および動脈硬化指標

大西丈二、飯田蓉子、小池晃彦、荒深裕規、梶岡多恵子、島岡清、柳本有二、榊原久孝

総合保健体育科学 Vol. 35 ( 1 ) page： 29-33 2012

BMI30kg/m2以上の若年肥満男性の食事および身体活動の特徴

夏目有紀枝、小池晃彦、押田芳治

総合保健体育科学 Vol. 35 ( 1 ) page： 35-40 2012

Inspiratory muscle fatigue increases sympathetic vasomotor outflow and blood pressure during submaximal exercise. Reviewed

Keisho Katayama, Erika Iwamoto, Koji Ishida1, Teruhiko Koike, and Mitsuru Saito.

Am J Physiol Regul Integr Comp Physiol Vol. 302 page： R1167-R1175 2012

Association between gait speed and bone strength in community-dwelling postmenopausal Japanese women. Reviewed

Takahiro Sakazaki, Teruhiko Koike, Yuji Yanagimoto, Yoshiharu Oshida.

Environ Health Prev Med 2012

Acute treatment with candesartan cilexetil, an angiotensin II type 1 receptor blocker, improves insulin sensitivity in high-fructose diet-fed rats. Reviewed

P. Li, T. Koike, H.Jiang, Z. Wang, Y. Kawata, Y. Oshida.

Horm Metab Res Vol. 44 ( 4 ) page： 286-290 2012

サルコペニアの今：サルコペニアの対策、予防と治療

小池晃彦、秋間広、柳本有二、片山敬章、石田浩司、坂崎貴彦、夏目有紀枝、押田芳治

運動・物理療法 Vol. 22 ( 3 ) page： 307-314 2011

Hypoxia augments muscle sympathetic neural response to leg cycling. Reviewed

Am J Physiol Regul Integr Comp Physiol Vol. 301 page： R456-R464 2011

高果糖食ラットでのスーパーハイブリッドガス充填水によるインスリン抵抗性改善効果

姜海英、小池晃彦、王忠華、木蘭、陳塔娜、夏目有紀枝、押田芳治

総合保健体育科学 Vol. 34 ( 1 ) page： 1-4 2011

国際生活機能分類(ICF)を用いた血液透析患者に対するアセスメントツールの開発

筒井秀代、多和田英夫、加藤ふみ、伊藤晃、山崎親雄、小池晃彦、押田芳治

腎臓 Vol. 34 ( 2 ) page： 129-133 2011

The effect of intense interval cycle-training on umloading-induced dysfunction and atrophy in the human calf muscle. Reviewed

Norio hotta, Koji Ishida, Kohei Sato, Teruhiko Koike, Keisho Katayama, Hiroshi Akima.

J Physiol Anthropol Vol. 30 ( 1 ) page： 29-35 2011

地域在住閉経後女性の骨強度と最速歩行時の速度・歩幅との関連－膝伸展力の影響－

坂崎貴彦、小池晃彦、柳本有二、森和、押田芳治

総合保健体育科学 Vol. 34 ( 1 ) page： 15-18 2011

特定健診受診者における運動習慣と健康関連QOLとの関連性－トランスセオリティカルモデルを用いた運動定着群と未定着群での比較

松本大輔、瓜谷大輔、浅野恭代、小池晃彦、押田芳治

総合保健体育科学 Vol. 34 ( 1 ) page： 5-9 2011

Alanine aminotransferase and γ-glutamyltransferase as markers for elevated insulin resistance–associated metabolic abnormalities in obese Japanese men younger than 30 years of age Reviewed

Teruhiko Koike, Maiko Miyamotob, Yoshiharu Oshida

Obesity Research & Clinical Practice Vol. 4 page： e73-e79 2010

医学部生における各種ウイルス抗体価の検討

山本明子、近藤孝晴、押田芳治、石黒洋、小池晃彦、小川豊明、津田均、古橋忠晃

総合保健体育科学 Vol. 33 ( 1 ) page： 65-70 2010

名古屋大学における「健康・スポーツ科学実習」授業に関する学生の意識調査－実習を選択しない学生の観点から－

石田浩司、西田保、蛭田秀一、片山敬章、山本裕二、石黒洋、小池晃彦、小林洋平

総合保健体育科学 Vol. 33 ( 1 ) page： 49-63 2010

J-SACLテストにより評価した2型糖尿病患者のストレスにおける男女差について

筒井秀世、小池晃彦、石黒哲也、押田芳治

総合保健体育科学 Vol. 33 ( 1 ) page： 17-21 2010

　特定健診参加者が求める運動環境

松本大輔、瓜谷大輔、浅野恭代、小池晃彦、押田芳治

総合保健体育科学 Vol. 33 ( 1 ) page： 1-5 2010

Combined effect of short-term calorie restriction and exercise on insulin action in normal rats. Reviewed

Haiying Jiang, Teruhiko Koike, Ping Li, Zhonghua Wang, Yuki Kawata, Yoshiharu Oshida.

Horm Metab Res Vol. in press 2010

*Waist circumference is positively associated with insulin resistance but not with fasting blood glucose among moderately to highly obese young Japanese men. Reviewed

T. Koike, M. Miyamoto, Y. Oshida.

Obesity Research & Clinical Practice Vol. 3 ( 109-114 ) 2009

中等度以上肥満男子学生でのウエスト周囲径と血糖コントロールとの関連

小池晃彦、押田芳治

CAMPUS HEALTH Vol. 46 ( 1 ) page： 164 2009

医療従事者養成教育にティーチング・アシスタント(TA)の月給制普及を（報告）

坂崎貴彦、小池晃彦、押田芳治

総合保健体育科学 Vol. 32 page： 21-23 2009

　大学ラグビー選手の身体組成・運動機能とハムストリングの肉離れとの関連

松本大輔、中本順、成瀬文博、山田実、小池晃彦、押田芳治

総合保健体育科学 Vol. 321 page： 25-29 2009

The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans. Reviewed

K. Sakuma, W Kohei, N Norio, T Koike, K Ishida, K Katayama, H Akima.

Acta Physiologica Vol. 197 page： 151-159 2009

Cycle ergometer exercise to counteract muscle atrophy during unilateral lower limb suspension. Reviewed

H. Akima, N Hotta, K Sato, K Ishida, T.Koike.

Aviat Space Environ Med Vol. 80 ( 7 ) page： 652-656 2009

Identification of hemodialysis patients' common problems using the International Classification of Functioning, Disability and Health. Reviewed

H. Tsutsui, T. Koike, C. Yamazaki, A. Ito, F. Kato, H. Sato, H. Tawada, Y. Oshida.

Therapeutic Apheresis and Dialysis Vol. 13 ( 3 ) page： 186-192 2009

Effects of Continuous Low-carbohydrate Diet after Long-term Exercise on GLUT-4 Protein Content in Rat Skeletal Muscle. Reviewed

M.Kubota, K.Koshinaka, Y. Kawata, T. Koike, Y. Oshida.

Horm Metab Res Vol. 40 ( 24 ) 2008

メタボリックシンドロームに対する運動・スポーツの有効性-耐糖能異常

押田芳治、川田裕樹、小池晃彦

体育の科学 Vol. 58 ( 7 ) page： 461-467 2008

*Raised homocysteine and low folate and vitamin B-12 concentrations predict cognitive decline in community-dwelling older Japanese adults. Reviewed

T. Koike, M. Kuzuya, K. Kanda, K. Okada, S. Izawa, H. Enoki, A. Iguchi.

Clin Nutr. Vol. 27 ( 6 ) page： 865-871 2008

A High-fructose diet impairs Akt and PKCζ, Phosphorylation and Glut4 translocation in rat skeletal muscle. Reviewed

P. Li, T. Koike, B. Qin, M. Kubota, Y. Kawata, Y. J. Jia, Y. Oshida.

Horm Metab Res Vol. 40 ( 8 ) page： 528-532 2008

肥満若年男性におけるウエスト周囲径とインスリン抵抗性との関連‐臍レベルウエスト周囲径と最小ウエスト周囲径の比較

小池晃彦、押田芳治

総合保健体育科学 Vol. 31 ( 1 ) page： 39-42 2008

ICFに用づいた血液透析患者に対するアセスメントツールの開発

筒井秀代、加藤ふみ、佐藤久光、伊藤晃、山崎親雄、多和田英夫、小池晃彦、押田芳治

透析会誌 Vol. 41 ( 4 ) page： 263 2008

肥満にともなうインスリン抵抗性に対するSNPの効果 Reviewed

賈燕君、久保田正和、小池晃彦、川田裕樹、筒井秀代、李平

総合保健体育科学 Vol. 30 ( 1 ) page： 57-60 2007

The nutritional status of frail elderly with care needs according to the mini-nutritional assessment. Reviewed

S. Izawa, M. Kuzuya, K. Okada, H. Enoki, T. Koike, S. Kanda, and A. Iguchi

Clin Nutr Vol. 25 page： 962-967 2006

The effect of total homocysteine elevation and related B vitamins deficiency on cognitive function and depression in elderly population Reviewed

Teruhiko Koike, Masafumi Kuzuya, Shigeru Kanda, Kiwako Okada, Sachiko Izawa, Hiromi Enoki, Akihisa Iguchi

Vitamins(Japan) Vol. 79 ( 12 ) page： 583-591 2005.12

Lack of correlation between total lymphocyte count and nutritional status in the elderly. Reviewed

M. Kuzuya, S. Kanda, T. Koike, Y. Suzuki, and A. Iguchi.

Clin Nutr Vol. 24 page： 427-432 2005

加齢が骨格筋のインスリン作用に及ぼす影響

久保田和、越中敬一、秦柏林、大澤功、小池晃彦、押田芳治

総合保健体育科学 Vol. 28 page： 9-13 2005

Elongation and secretion of tissue inhibitor of metalloproteinases 1 by human microvascular endothelium cells cultured in collagen gels is stimulated by mitomycin C. Reviewed

MA Hamner, RB Vernon, MD Gooden, T. Koike, MJ Reed

Endothelium Vol. 12 page： 97-101 2005

Evaluation of Mini-Nutritional Assessment for Japanese frail elderly. Reviewed

M. Kuzuya, S. Kanda, T. Koike, Y. Suzuki, S. Satake, and A. Iguchi

Nutrition Vol. 21 page： 498-503 2005

Increased Expression of Elastolysis Cysteine Proteases, Cathepsins S and K, in the neointima of balloon-injured rat carotid arteries. Reviewed

XW. Cheng, M. Kuzuya, T. Sasaki, A. Koji, S. Kanda, D. Sumi, T. Koike, K, Maeda, N, Tamaya-Mori, G-P. Shi, N. Saito, and A. Iguchi.

Am. J. Pathol. Vol. 164 page： 243-251 2004

A novel model of occlusive thrombus formation in mice. Reviewed

T. Sasaki, M. Kuzuya, XW. Cheng, K, Nakamura, N. Tamaya-Mori, K. Maeda, S. Kanda, T. Koike, K. Sato, and A. Iguchi.

Lab. Invest. Vol. 84 page： 1526-1532 2004

Green tea catechins inhibit neointimal hyperplasia in a rat carotid arterial injury model by TIMP-2 overexpression. Reviewed

XW. Cheng, M. Kuzuya, T. Sasaki, S. Kanda, N. Tamaya-Mori, T. Koike, K, Maeda, N, E. Nishitani, and A. Iguchi.

Cardiovas Res. Vol. 62 page： 594-602 2004

Sarcopeniaの対策

小池晃彦、葛谷雅文、井口昭久

Vol. 42 page： 919-923 2004

Inhibition of TIMP1 enhances angiogenesis in vivo and cell migration in vitro. Reviewed

M.J.Reed, T.Koike, E. Sadoun, E.H.Sage, P.Puolakkainen.

Mircovasc. Res. Vol. 65 page： 9-17 2003

Atorvastatin, HMG-CoA reductase inhibitor, reduces bone resorption in the elderly. Reviewed

M. Kuzuya, Y. Suzuki, T. Asai, T. Koike, S. Kanda, A. Nakamura, S. Satake, H. Umegaki, A. Iguchi..

Journal of American Geriatric Society Vol. 51 page： 1677-1678 2003

*Inhibited Angiogenesis in Aging: A Role for TIMP-2. Reviewed

T.Koike, RB.Vernon, MD Gooden, E Sadoun, MJ. Reed.

J. Gerontol A Biol Sci Med Sci. Vol. 58 page： B798-805 2003

* MT1-MMP, but not secreted MMPs, influences the migration of human microvascular endothelial cells in 3-dimensional collagen gels. Reviewed

T. Koike, R.B.Vernon, M.A.Hamner, E. Sadoun, M.J. Reed.

J. Cell Biochem. Vol. 86 ( 748-758 ) 2002

高齢者に対するCarvedilolの心血行動態に及ぼす作用と忍容性の検討 Reviewed

浅井俊亘、葛谷雅文、小池晃彦、神田茂、前田恵子、井口昭久

日老医誌 Vol. 39 page： 187-192 2002

Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways. Reviewed

S. Ai, M. Kuzuya, T. Koike, T. Asai, S. Kanda, K. Maeda, T. Shibata, and A. Iguchi.

Atherosclerosis Vol. 155 page： 321-327 2001

VEGF Protects against oxidized LDL toxicity to endothelial cells by an intracellular glutathione-dependent mechanism through the KDR receptor. Reviewed

M. Kuzuya, MA.Ramos, S. Kanda, T. Koike, T. Asai, K. Maeda, K. Shitara, and M. Shibuya, and A. Iguchi.

Arterioscler Thromb Vasc Biol. Vol. 21 page： 765-770 2001

Matrix Metalloproteinase and v3 integrin-dependent vascular smooth muscle cell invasion through the type I collagen lattice. Reviewed

S. Kanda, M. Kuzuya, M.A.Ramos, T. Koike, Y. Yoshino, S. Ikeda, and A. Iguchi.

Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 20 page： 998-1005 2000

Activation of MMP-2 by Clostridium difficile toxin B in bovine smooth muscle cells. Reviewed

T. Koike, M. Kuzuya, T. Asai, S. Kanda, X. W. Cheng, Y. Banno, K. Watanabe, Y. Nozawa, and A. Iguchi.

Biochem. Biophys.Res.Commun. Vol. 277 page： 43-46 2000

Induction of apoptotic cell death in vascular endothelial cell cultured in 3-dimentional collagen lattice. Reviewed

M. Kuzuya, S. Satake, M. A. Ramos, S. Kanda, T. Koike, K. Yoshino, S. Ikeda, and A. Iguchi.

Experimental Cell Research Vol. 248 page： 498-508 1999

Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1. Reviewed

A. A. Thant, T. T. Sein, E. Liu, M. Kazuya, F. Kikkawa, T. Koike, S. Motoharu, S. Matsuda, and M. Hamaguchi.

Oncogene Vol. 18 page： 6555-6563 1999

多剤投与に対する注意と工夫

小池晃彦、井口昭久

臨床と研究 Vol. 75 ( 2 ) 1998

Tyrosine phosphorylation is crucial for growth signaling by tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2). Reviewed

K. Yamashita, M. Suzuki, H. Iwata, T. Koike, M. Hamaguchi, A. Shinagawa, T. Noguchi, and T. Hayakawa.

FEBS. Lett. Vol. 396 page： 103-107 1996

Evidence of a novel redox-linked activation mechanism for the Src kinase which is independent of tyrosine 527-mediated regulation. Reviewed

M. Pu, A. Akhand, M. Kato, M. Hamaguchi, T. Koike, H. Iwata, H. Sabe, H. Suzuki, and I. Nakashima.

Oncogene Vol. 13 page： 2615-2622 1996

Mercuric chloride mediates a protein sulfhydryl modification-based pathway of signal transduction for activating Src kinase which is independent of the phosphorylation /dephosphorylation of a carboxy terminal tyrosine. Reviewed

M. Pu, A. Akhand, M. Kato, T. Koike, M. Hamaguchi, H. Suzuki, and I. Nakashima.

J. Cell. Biochem. Vol. 63 page： 104-114 1996

The structure and function of cadherins and their pathophysiological roles in diseases

Vol. 53 ( 7 ) page： 1578-1584 1995

*Stem cell factor-induced signal transduction in rat mast cells. Reviewed

T. Koike, K. Hirai, Y. Morita, and Y. Nozawa.

J. Immunol. Vol. 151 page： 359-366 1993

SCF/c-kit receptor mediated arachidonic acid liberation in rat mast cells. Reviewed

T. Koike, Mizutani, K. Hirai, Y. Morita, and Y. Nozawa.

Biochem. Biophys. Res. Comm. Vol. 197 page： 1570-1577 1993

血小板活性化の情報伝達

永田浩一、小池晃彦、鈴木武志、野澤義則

実験医学（増刊　情報伝達研究の新しい展開） Vol. 11 page： 191-196 1993

ホスホリパーゼDの活性化機構

金保安則、加納宏行、小池晃彦、岡野幸雄、野澤義則

実験医学（増刊　情報伝達研究の新しい展開） Vol. 11 page： 31-37 1993

血小板系　3. イノシトールリン脂質代謝と細胞応答　病態にも関連して Invited

岡野幸雄、小池晃彦、永田浩一、野澤義則

臨床病理 Vol. 91 page： 194-204 1991

Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses. Reviewed

S. Nakashima, T. Koike, and Y. Nozawa

Mol. Pharmacol. Vol. 39 page： 475-480 1991

血小板シグナル伝導系

小池晃彦、中島茂、野澤義則

治療 Vol. 73 page： 913-920 1991

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