Faculty Profiles - KOIKE, Teruhiko

Papers - KOIKE, Teruhiko

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EFFECT OF D-ALLULOSE ON INSULIN RESISTANCE AND ENDURANCE ABILITY: IS D-ALLULOSE AN EXERCISE MIMETIC?

Koike, T; Gou, Y; Liu, BY; Natsume, Y; Tsuzuki, T; Shahriar, K; Banno, R

INNOVATION IN AGING Vol. 8 page： 876 - 876 2024.12

Relationship Of Skeletal Muscle Oxidative Capacity With Intramyocellular And Extramyocellular Lipids In Young And Older Individuals

Yoshiko, A; Shiozawa, K; Niwa, S; Takahashi, H; Koike, T; Watanabe, K; Katayama, K; Akima, H

MEDICINE & SCIENCE IN SPORTS & EXERCISE Vol. 56 ( 10 ) page： 7 - 7 2024.10

Factors Related To Trunk Intramuscular Adipose Tissue Content - Comparison Of Younger And Older Men

Kitagawa Funa, Tanaka Noriko, Ogawa Madoka, Yoshiko Akito, Oshida Yoshiharu, Koike Teruhiko, Akima Hiroshi

MEDICINE & SCIENCE IN SPORTS & EXERCISE Vol. 54 ( 9 ) page： 530 - 530 2022.9

The Relationship Between Serum Igf-1 And Fat Deposition Of Thigh In Younger And Older Men

Ogawa Madoka, Tanaka Noriko, Yoshiko Akito, Oshida Yoshiharu, Koike Teruhiko, Akima Hiroshi

MEDICINE & SCIENCE IN SPORTS & EXERCISE Vol. 54 ( 9 ) page： 529 - 529 2022.9

Relationships Between Skeletal Muscle Lipids And Muscle Functional Performances In Older Individuals

Yoshiko Akito, Maeda Hisashi, Takahashi Hideyuki, Koike Teruhiko, Tanaka Noriko I., Akima Hiroshi

MEDICINE & SCIENCE IN SPORTS & EXERCISE Vol. 54 ( 9 ) page： 531 - 531 2022.9

Importance of skeletal muscle lipid levels for muscle function and physical function in older individuals

Yoshiko Akito, Maeda Hisashi, Takahashi Hideyuki, Koike Teruhiko, Tanaka Noriko, Akima Hiroshi

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM Vol. 47 ( 6 ) page： 649 - 658 2022.6

Combined effects of exercise training and D-allulose intake on endurance capacity in mice. International journal

Takamasa Tsuzuki, Ryo Suzuki, Risa Kajun, Takako Yamada, Tetsuo Iida, Bingyang Liu, Teruhiko Koike, Yukiyasu Toyoda, Takayuki Negishi, Kazunori Yukawa

Physiological reports Vol. 10 ( 9 ) page： e15297 2022.5

Language：Japanese Publishing type：Research paper (scientific journal)

This study investigated the combined effects of exercise training and D-allulose intake on endurance capacity in mice. Male C57BL/6J mice were fed either a control diet (Con) or a 3% D-allulose diet (Allu) and further divided into the sedentary (Sed) or exercise training (Ex) groups (Con-Sed, Con-Ex, Allu-Sed, Allu-Ex, respectively; n = 6-7/group). The mice in the Ex groups were trained on a motor-driven treadmill 5 days/week for 4 weeks (15-18 m/min, 60 min). After the exercise training period, all mice underwent an exhaustive running test to assess their endurance capacity. At 48 h after the running test, the mice in the Ex groups were subjected to run at 18 m/min for 60 min again. Then the gastrocnemius muscle and liver were sampled immediately after the exercise bout. The running time until exhaustion tended to be higher in the Allu-Ex than in the Con-Ex group (p = 0.08). The muscle glycogen content was significantly lower in the Con-Ex than in the Con-Sed group and was significantly higher in the Allu-Ex than in the Con-Ex group (p < 0.05). Moreover, exercise training increased the phosphorylation levels of adenosine monophosphate-activated protein kinase (AMPK) in the muscle and liver. The phosphorylation levels of acetyl coenzyme A carboxylase (ACC), a downstream of AMPK, in the muscle and liver were significantly higher in the Allu-Ex than in the Con-Sed group (p < 0.05), suggesting that the combination of exercise training and D-allulose might have activated the AMPK-ACC signaling pathway, which is associated with fatty acid oxidation in the muscle and liver. Taken together, our data suggested the combination of exercise training and D-allulose intake as an effective strategy to upregulate endurance capacity in mice. This may be associated with sparing glycogen content and enhancing activation of AMPK-ACC signaling in the skeletal muscle.

DOI： 10.14814/phy2.15297

Web of Science

PubMed

Contribution of skeletal muscle and serum lipids to muscle contraction induced by neuromuscular electrical stimulation in older individuals

Akito Yoshiko, Hisashi Maeda, Hideyuki Takahashi, Teruhiko Koike, Noriko Tanaka, Hiroshi Akima

Physiological Reports Vol. 10 ( 6 ) 2022.3

d-Allulose Improves Endurance and Recovery from Exhaustion in Male C57BL/6J Mice. International journal

Bingyang Liu, Yang Gou, Takamasa Tsuzuki, Takako Yamada, Tetsuo Iida, Sixian Wang, Ryoichi Banno, Yukiyasu Toyoda, Teruhiko Koike

Nutrients Vol. 14 ( 3 ) 2022.2

Language：Japanese Publishing type：Research paper (scientific journal)

d-Allulose, a rare sugar, improves glucose metabolism and has been proposed as a candidate calorie restriction mimetic. This study aimed to investigate the effects of d-allulose on aerobic performance and recovery from exhaustion and compared them with the effects of exercise training. Male C57BL/6J mice were subjected to exercise and allowed to run freely on a wheel. Aerobic performance was evaluated using a treadmill. Glucose metabolism was analyzed by an intraperitoneal glucose tolerance test (ipGTT). Skeletal muscle intracellular signaling was analyzed by Western blotting. Four weeks of daily oral administration of 3% d-allulose increased running distance and shortened recovery time as assessed by an endurance test. d-Allulose administration also increased the maximal aerobic speed (MAS), which was observed following treatment for >3 or 7 days. The improved performance was associated with lower blood lactate levels and increased liver glycogen levels. Although d-allulose did not change the overall glucose levels as determined by ipGTT, it decreased plasma insulin levels, indicating enhanced insulin sensitivity. Finally, d-allulose enhanced the phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase and the expression of peroxisome proliferator-activated receptor γ coactivator 1α. Our results indicate that d-allulose administration enhances endurance ability, reduces fatigue, and improves insulin sensitivity similarly to exercise training. d-Allulose administration may be a potential treatment option to alleviate obesity and enhance aerobic exercise performance.

DOI： 10.3390/nu14030404

Web of Science

PubMed

The Neural Correlates of Semantic and Grammatical Encoding During Sentence Production in a Second Language: Evidence From an fMRI Study Using Structural Priming

Nakagawa Eri, Koike Takahiko, Sumiya Motofumi, Shimada Koji, Makita Kai, Yoshida Haruyo, Yokokawa Hirokazu, Sadato Norihiro

FRONTIERS IN HUMAN NEUROSCIENCE Vol. 15 2022.1

Relationship between adiponectin and intramuscular fat content determined by ultrasonography in older adults

Maya Hioki, Nana Kanehira, Teruhiko Koike, Akira Saito, Kiyoshi Shimaoka, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima

PLOS ONE Vol. 17 ( 1 ) page： e0262271 - e0262271 2022.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Public Library of Science (PLoS)

Age-associated intramuscular adipose tissue (IntraMAT) deposition induces the development of insulin resistance and metabolic syndrome. However, the relationship between IntraMAT and biochemical parameters in older adults remains unclear. The purpose of this study, therefore, was to elucidate the relationship between adiponectin and echo intensity–estimated IntraMAT using ultrasonography in normal-weight older adults (men 9, women 13) and examine biochemical parameters. Blood tests were performed to determine fasting levels of glucose, insulin, hemoglobin A1c, total cholesterol (Total-C), high-density-lipoprotein cholesterol, low-density-lipoprotein cholesterol (LDL-C), free fatty acid, triglycerides (TGs), adiponectin, leptin, high-sensitivity C-reactive protein, and high-sensitivity tumor necrosis factor, and homoeostasis model assessment index of insulin resistance (HOMA-IR). Mean gray-scale echo intensity was calculated as the IntraMAT index of the vastus lateralis. Waist circumference was measured at the level of the navel as the visceral adipose tissue (VAT) index. Echo intensity was significantly inversely correlated with adiponectin or LDL-C, and that was significantly positively correlated with TG. Adiponectin level was inversely correlated with waist circumference. Partial correlation analysis with waist circumference as the control variable revealed that adiponectin was inversely correlated with echo intensity, independent of waist circumference, whereas no such correlation was observed after controlling for LDL-C and TG levels. When biochemical parameters were grouped in the principal component analysis, among men, Total-C, insulin, and HOMA-IR or hemoglobin A1c, and high-sensitivity tumor necrosis factor–alpha were grouped with the same distribution for factors 1 and 2. Among women, glucose, insulin, HOMA-IR, and Total-C or TGs were grouped with the same distribution for factors 1 and 2. These data suggest that adiponectin level is related to IntraMAT content, independent of VAT in normal-weight older adults. The dynamics of adiponectin might not be similar to those of other circulating biochemical parameters in older men and women.

DOI： 10.1371/journal.pone.0262271

Web of Science

Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis. International journal

Akihiro Ryuge, Tomoki Kosugi, Kayaho Maeda, Ryoichi Banno, Yang Gou, Kei Zaitsu, Takanori Ito, Yuka Sato, Akiyoshi Hirayama, Shoma Tsubota, Takashi Honda, Kazuki Nakajima, Tomoya Ozaki, Kunio Kondoh, Kazuo Takahashi, Noritoshi Kato, Takuji Ishimoto, Tomoyoshi Soga, Takahiko Nakagawa, Teruhiko Koike, Hiroshi Arima, Yukio Yuzawa, Yasuhiko Minokoshi, Shoichi Maruyama, Kenji Kadomatsu

JCI insight Vol. 6 ( 20 ) 2021.10

Language：Japanese Publishing type：Research paper (scientific journal)

Monocarboxylates, such as lactate and pyruvate, are precursors for biosynthetic pathways, including those for glucose, lipids, and amino acids via the tricarboxylic acid (TCA) cycle and adjacent metabolic networks. The transportation of monocarboxylates across the cellular membrane is performed primarily by monocarboxylate transporters (MCTs), the membrane localization and stabilization of which are facilitated by the transmembrane protein basigin (BSG). Here, we demonstrate that the MCT/BSG axis sits at a crucial intersection of cellular metabolism. Abolishment of MCT1 in the plasma membrane was achieved by Bsg depletion, which led to gluconeogenesis impairment via preventing the influx of lactate and pyruvate into the cell, consequently suppressing the TCA cycle. This net anaplerosis suppression was compensated in part by the increased utilization of glycogenic amino acids (e.g., alanine and glutamine) into the TCA cycle and by activated ketogenesis through fatty acid β-oxidation. Complementary to these observations, hyperglycemia and hepatic steatosis induced by a high-fat diet were ameliorated in Bsg-deficient mice. Furthermore, Bsg deficiency significantly improved insulin resistance induced by a high-fat diet. Taken together, the plasma membrane-selective modulation of lactate and pyruvate transport through BSG inhibition could potentiate metabolic flexibility to treat metabolic diseases.

DOI： 10.1172/jci.insight.142464

Web of Science

PubMed

Relationship between physical activity time and intramuscular adipose tissue content of the thigh muscle groups of younger and older men

Ogawa Madoka, Tanaka Noriko, Yoshiko Akito, Oshida Yoshiharu, Koike Teruhiko, Akima Hiroshi

SCIENTIFIC REPORTS Vol. 11 ( 1 ) 2021.10

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats. International journal

Yang Gou, Bingyang Liu, Mengyao Cheng, Takako Yamada, Tetsuo Iida, Sixian Wang, Ryoichi Banno, Teruhiko Koike

Molecules (Basel, Switzerland) Vol. 26 ( 20 ) 2021.10

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: d-Allulose is a rare sugar with antiobesity and antidiabetic activities. However, its direct effect on insulin sensitivity and the underlying mechanism involved are unknown. OBJECTIVE: This study aimed to investigate the effect of d-allulose on high-fat diet (HFD)-induced insulin resistance using the hyperinsulinemic-euglycemic (HE)-clamp method and intramuscular signaling analysis. METHODS: Wistar rats were randomly divided into three dietary groups: chow diet, HFD with 5% cellulose (HFC), and HFD with 5% d-allulose (HFA). After four weeks of feeding, the insulin tolerance test (ITT), intraperitoneal glucose tolerance test (IPGTT), and HE-clamp study were performed. The levels of plasma leptin, adiponectin, and tumor necrosis factor (TNF)-α were measured using the enzyme-linked immunosorbent assay. We analyzed the levels of cell signaling pathway components in the skeletal muscle using Western blotting. RESULTS: d-allulose alleviated the increase in HFD-induced body weight and visceral fat and reduced the area under the curve as per ITT and IPGTT. d-Allulose increased the glucose infusion rate in the two-step HE-clamp test. Consistently, the insulin-induced phosphorylation of serine 307 in the insulin receptor substrate-1 and Akt and expression of glucose transporter 4 (Glut-4) in the muscle were higher in the HFA group than HFC group. Furthermore, d-allulose decreased plasma TNF-α concentration and insulin-induced phosphorylation of stress-activated protein kinase/Jun N-terminal kinase in the muscle and inhibited adiponectin secretion in HFD-fed rats. CONCLUSIONS: d-allulose improved HFD-induced insulin resistance in Wistar rats. The reduction of the proinflammatory cytokine production, amelioration of adiponectin secretion, and increase in insulin signaling and Glut-4 expression in the muscle contributed to this effect.

DOI： 10.3390/molecules26206310

Web of Science

PubMed

Investigation of D-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats

Natsume Yukie, Yamada Takako, Iida Tetsuo, Ozaki Nobuaki, Gou Yang, Oshida Yoshiharu, Koike Teruhiko

HELIYON Vol. 7 ( 9 ) 2021.9

Effect of electromyostimulation on intramyocellular lipids of the vastus lateralis in older adults: a randomized controlled trial

Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Takahashi Hideyuki, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

BMC MUSCULOSKELETAL DISORDERS Vol. 22 ( 1 ) 2021.6

Effect of elbow joint angles on electromyographic activity versus force relationships of synergistic muscles of the triceps brachii

Akima Hiroshi, Maeda Hisashi, Koike Teruhiko, Ishida Koji

PLOS ONE Vol. 16 ( 6 ) 2021.6

Eicosapentaenoic acid enhances skeletal muscle hypertrophy without altering the protein anabolic signaling pathway. Reviewed

Siriguleng, T. Koike, Y. Natsume, H. Jiang, L. Mu, Y. Oshida

Physiol Res Vol. 70 ( 1 ) page： 55 - 65 2021.2

Comparison Of Fascicle Behaviors Between Superficial And Deeper Muscles Of Triceps Brachii During Isometric Contractions

Akima Hiroshi, Maeda Hisashi, Koike Teruhiko, Ishida Koji, Ando Ryosuke

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 52 ( 17 ) page： 946 - 946 2020.7

Comparison Of Fascicle Behaviors Between Superficial And Deeper Muscles Of Triceps Brachii During Isometric Contractions

Akima Hiroshi, Maeda Hisashi, Koike Teruhiko, Ishida Koji, Ando Ryosuke

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE Vol. 52 ( 17 ) page： 946 - 946 2020.7

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Papers - KOIKE, Teruhiko