Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

DOI： 10.14814/phy2.15236

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.14814/phy2.15236

Language：Japanese   Publishing type：Research paper (scientific journal)  

d-Allulose, a rare sugar, improves glucose metabolism and has been proposed as a candidate calorie restriction mimetic. This study aimed to investigate the effects of d-allulose on aerobic performance and recovery from exhaustion and compared them with the effects of exercise training. Male C57BL/6J mice were subjected to exercise and allowed to run freely on a wheel. Aerobic performance was evaluated using a treadmill. Glucose metabolism was analyzed by an intraperitoneal glucose tolerance test (ipGTT). Skeletal muscle intracellular signaling was analyzed by Western blotting. Four weeks of daily oral administration of 3% d-allulose increased running distance and shortened recovery time as assessed by an endurance test. d-Allulose administration also increased the maximal aerobic speed (MAS), which was observed following treatment for >3 or 7 days. The improved performance was associated with lower blood lactate levels and increased liver glycogen levels. Although d-allulose did not change the overall glucose levels as determined by ipGTT, it decreased plasma insulin levels, indicating enhanced insulin sensitivity. Finally, d-allulose enhanced the phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase and the expression of peroxisome proliferator-activated receptor γ coactivator 1α. Our results indicate that d-allulose administration enhances endurance ability, reduces fatigue, and improves insulin sensitivity similarly to exercise training. d-Allulose administration may be a potential treatment option to alleviate obesity and enhance aerobic exercise performance.

DOI： 10.3390/nu14030404

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PubMed

DOI： 10.3389/fnhum.2021.753245

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Public Library of Science (PLoS)  

Age-associated intramuscular adipose tissue (IntraMAT) deposition induces the development of insulin resistance and metabolic syndrome. However, the relationship between IntraMAT and biochemical parameters in older adults remains unclear. The purpose of this study, therefore, was to elucidate the relationship between adiponectin and echo intensity–estimated IntraMAT using ultrasonography in normal-weight older adults (men 9, women 13) and examine biochemical parameters. Blood tests were performed to determine fasting levels of glucose, insulin, hemoglobin A1c, total cholesterol (Total-C), high-density-lipoprotein cholesterol, low-density-lipoprotein cholesterol (LDL-C), free fatty acid, triglycerides (TGs), adiponectin, leptin, high-sensitivity C-reactive protein, and high-sensitivity tumor necrosis factor, and homoeostasis model assessment index of insulin resistance (HOMA-IR). Mean gray-scale echo intensity was calculated as the IntraMAT index of the vastus lateralis. Waist circumference was measured at the level of the navel as the visceral adipose tissue (VAT) index. Echo intensity was significantly inversely correlated with adiponectin or LDL-C, and that was significantly positively correlated with TG. Adiponectin level was inversely correlated with waist circumference. Partial correlation analysis with waist circumference as the control variable revealed that adiponectin was inversely correlated with echo intensity, independent of waist circumference, whereas no such correlation was observed after controlling for LDL-C and TG levels. When biochemical parameters were grouped in the principal component analysis, among men, Total-C, insulin, and HOMA-IR or hemoglobin A1c, and high-sensitivity tumor necrosis factor–alpha were grouped with the same distribution for factors 1 and 2. Among women, glucose, insulin, HOMA-IR, and Total-C or TGs were grouped with the same distribution for factors 1 and 2. These data suggest that adiponectin level is related to IntraMAT content, independent of VAT in normal-weight older adults. The dynamics of adiponectin might not be similar to those of other circulating biochemical parameters in older men and women.

DOI： 10.1371/journal.pone.0262271

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Language：Japanese   Publishing type：Research paper (scientific journal)  

Monocarboxylates, such as lactate and pyruvate, are precursors for biosynthetic pathways, including those for glucose, lipids, and amino acids via the tricarboxylic acid (TCA) cycle and adjacent metabolic networks. The transportation of monocarboxylates across the cellular membrane is performed primarily by monocarboxylate transporters (MCTs), the membrane localization and stabilization of which are facilitated by the transmembrane protein basigin (BSG). Here, we demonstrate that the MCT/BSG axis sits at a crucial intersection of cellular metabolism. Abolishment of MCT1 in the plasma membrane was achieved by Bsg depletion, which led to gluconeogenesis impairment via preventing the influx of lactate and pyruvate into the cell, consequently suppressing the TCA cycle. This net anaplerosis suppression was compensated in part by the increased utilization of glycogenic amino acids (e.g., alanine and glutamine) into the TCA cycle and by activated ketogenesis through fatty acid β-oxidation. Complementary to these observations, hyperglycemia and hepatic steatosis induced by a high-fat diet were ameliorated in Bsg-deficient mice. Furthermore, Bsg deficiency significantly improved insulin resistance induced by a high-fat diet. Taken together, the plasma membrane-selective modulation of lactate and pyruvate transport through BSG inhibition could potentiate metabolic flexibility to treat metabolic diseases.

DOI： 10.1172/jci.insight.142464

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PubMed

Language：Japanese  

DOI： 10.1038/s41598-021-99126-x

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Language：Japanese   Publishing type：Research paper (scientific journal)  

BACKGROUND: d-Allulose is a rare sugar with antiobesity and antidiabetic activities. However, its direct effect on insulin sensitivity and the underlying mechanism involved are unknown. OBJECTIVE: This study aimed to investigate the effect of d-allulose on high-fat diet (HFD)-induced insulin resistance using the hyperinsulinemic-euglycemic (HE)-clamp method and intramuscular signaling analysis. METHODS: Wistar rats were randomly divided into three dietary groups: chow diet, HFD with 5% cellulose (HFC), and HFD with 5% d-allulose (HFA). After four weeks of feeding, the insulin tolerance test (ITT), intraperitoneal glucose tolerance test (IPGTT), and HE-clamp study were performed. The levels of plasma leptin, adiponectin, and tumor necrosis factor (TNF)-α were measured using the enzyme-linked immunosorbent assay. We analyzed the levels of cell signaling pathway components in the skeletal muscle using Western blotting. RESULTS: d-allulose alleviated the increase in HFD-induced body weight and visceral fat and reduced the area under the curve as per ITT and IPGTT. d-Allulose increased the glucose infusion rate in the two-step HE-clamp test. Consistently, the insulin-induced phosphorylation of serine 307 in the insulin receptor substrate-1 and Akt and expression of glucose transporter 4 (Glut-4) in the muscle were higher in the HFA group than HFC group. Furthermore, d-allulose decreased plasma TNF-α concentration and insulin-induced phosphorylation of stress-activated protein kinase/Jun N-terminal kinase in the muscle and inhibited adiponectin secretion in HFD-fed rats. CONCLUSIONS: d-allulose improved HFD-induced insulin resistance in Wistar rats. The reduction of the proinflammatory cytokine production, amelioration of adiponectin secretion, and increase in insulin signaling and Glut-4 expression in the muscle contributed to this effect.

DOI： 10.3390/molecules26206310

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PubMed

Language：Japanese  

DOI： 10.1016/j.heliyon.2021.e08013

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Language：Japanese  

DOI： 10.1186/s12891-021-04456-6

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Language：Japanese  

DOI： 10.1371/journal.pone.0252644

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.33549/physiolres.934534

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Language：Japanese  

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Language：Japanese  

Language：Japanese  

DOI： 10.1016/j.exger.2020.110834

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Language：Japanese   Publishing type：Research paper (scientific journal)  

Web of Science

Language：Japanese   Publishing type：Research paper (scientific journal)  

Language：English   Publishing type：Research paper (scientific journal)  

Muscle function and exercise performance measures, such as muscle endurance capacity, maximal strength, chair stand score, gait speed, and Timed Up and Go score, are evaluated to diagnose sarcopenia and frailty in older individuals. Furthermore, intramuscular adipose tissue (IntraMAT) content increases with age. Skeletal muscle oxidative capacity determines muscle metabolism and maintains muscle performance. This study aimed to investigate the association of skeletal muscle oxidative capacity with muscle function, exercise performance, and IntraMAT content in older individuals. Thirteen older men and women participated in this study. Skeletal muscle oxidative capacity was assessed by the recovery speed of muscle oxygen saturation after exercise using near-infrared spectroscopy from the medial gastrocnemius. We assessed two muscle functions, peak torque and time to task failure, and four sarcopenia-related exercise performances: handgrip strength, gait speed, 30-s chair stand, and Timed Up and Go. The IntraMAT content was measured using axial magnetic resonance imaging. The results showed a relationship between skeletal muscle oxidative capacity and gait speed but not with muscle functions and other exercise performance measures. Skeletal muscle oxidative capacity was not related to IntraMAT content. Skeletal muscle oxidative capacity, which may be indicative of the capacity of muscle energy production in the mitochondria, is related to locomotive functions but not to other functional parameters or skeletal fat infiltration.

DOI： 10.1007/s11357-023-01043-6

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PubMed

Language：English   Publishing type：Research paper (scientific journal)  

The present study investigated factors related to trunk intramuscular adipose tissue (IntraMAT) content in younger and older men. Twenty-three healthy younger (20 to 29 years) and 20 healthy older men (63 to 79 years) participated in this study. The trunk IntraMAT content was measured using magnetic resonance imaging at the height of the 3rd lumbar vertebra. In addition to blood properties and physical performance, dietary intake was assessed by a self-administered diet history questionnaire. The dietary intake status was quantified using the nutrient adequacy score for the intake of 10 selected nutrients by summing the number of items that met the criteria of dietary reference intakes for Japanese individuals. The results obtained revealed that the trunk IntraMAT content was significantly higher in the older group than in the younger group (p < 0.05). In the younger group, the trunk IntraMAT content significantly correlated with systolic and diastolic blood pressure and HbA1c (rs = 0.443 to 0.464, p < 0.05). In the older group, significant and negative correlations were observed between the trunk IntraMAT content and 5-m usual walking speed, handgrip strength, and nutrient adequacy scores (rs = -0.485 to -0.713, p < 0.05). These results indicate that factors associated with the trunk IntraMAT content differed in an age dependent manner. In the younger group, the trunk IntraMAT content correlated with the metabolic status such as blood pressure and HbA1c. In the older group, physical performance and the dietary intake status negatively correlated with the trunk IntraMAT content.

DOI： 10.1016/j.exger.2022.111922

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PubMed

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

DOI： 10.1016/j.jelekin.2020.102452

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1371/journal.pone.0231156

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Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/s41598-019-57099-y

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE INC  

This study was performed to identify factors that discriminate muscle echo intensity (EI) among parameters of body composition, physical function and daily physical activity in elderly individuals. A total of 209 men and women (73.7 +/- 2.8 y) were evaluated. EI was measured on ultrasonographic axial thigh muscle images. The participants were categorized into the low, mid and high EI groups. We measured the skeletal muscle mass index (SMI) and physical functions. The high EI group exhibited a significantly lower SMI, slower 5-m walking time and shorter 6-min walking distance than the low EI group and had a shorter moderate-intensity activity time than the mid EI group. As a result of the discriminant analysis, elderly individuals were categorized into EI groups by SMI, daily activity and physical function. The data indicate that morphologic and functional parameters and the daily activity level help to discriminate higher and lower muscle EI. (C) 2019 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

DOI： 10.1016/j.ultrasmedbio.2019.05.029

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Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s12603-019-1208-8

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00421-018-4005-x

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1186/s11556-018-0201-2

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Springer Verlag  

Objective: Disuse and/or a non-weight-bearing condition changes muscle composition, with decreased skeletal muscle tissue and increased fat within (intramuscular adipose tissue, IntraMAT) and between (intermuscular adipose tissue, InterMAT) given muscles. Excessive adipose tissue contributes to dysfunctional and metabolically impaired muscle. How these adipose tissues change during orthopedic treatment (e.g., cast immobilization, daily use of crutches) is not well documented. This study aimed to quantify changes in IntraMAT, InterMAT, and thigh and calf muscle tissue during orthopedic treatment. Materials and methods: We studied 8 patients with fifth metatarsal bone or fibular fractures. The ankle joint involved underwent plaster casting for approximately 4 weeks, with crutches used during that time. Axial T1-weighted MRI at the mid-thigh and a 30% proximal site at the calf were obtained to measure IntraMAT and InterMAT cross-sectional areas (CSAs) and skeletal muscle tissue CSA before treatment and 4 weeks afterward. Results: Thigh and calf muscle tissue CSAs were significantly decreased from before to after treatment: thigh, 85.8 ± 7.6 to 77.1 ± 7.3 cm2
calf, 53.3 ± 5.5 to 48.9 ± 5.0 cm2 (p &lt
0.05). None of the IntraMAT or InterMAT changes was statistically significant. There was a relation between the percentage change of thigh IntraMAT CSA and muscle tissue CSA (rs = −0.86, p &lt
0.01). Conclusions: The 4 weeks of treatment primarily induced skeletal muscle atrophy with less of an effect on IntraMAT or InterMAT. There is a risk of increasing IntraMAT relatively by decreasing skeletal muscle tissue size during orthopedic treatment.

DOI： 10.1007/s00256-018-2985-6

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Scopus

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Springer Verlag  

Purpose: The ratio of fat within skeletal muscle is an important parameter that is indicative of muscle quality, and can be assessed using ultrasonography to measure echo intensity (EI). Muscle EI indicates muscle strength and risk of physical dysfunction
however, this observation was determined following examinations of only selected muscle. The purpose of this study was to investigate the EI characteristics of muscles in several regions in elderly men and women, using physical function tests and serum cholesterol levels. Methods: Twenty-two men and women (age 78 ± 8 years) participated in this study. The EIs were calculated from rectus femoris (RF), biceps femoris (BF) triceps brachii (TB) and multifidus (MF) using B-mode transverse ultrasound images. Seven functional tests (isometric knee-extension peak torque, functional reach, sit-to-stand, 5-m normal/maximal speed walking, handgrip strength and timed up-and-go) and blood lipid components including adipocytokines were measured in all participants. Results: A statistically significant correlation between EI of the RF, TB and BF was observed (r = 0.46–0.50, P &lt
0.05), but not between EI of the MF and that of other muscles. EI of muscles of the limbs, which was averaged EI for RF, TB and BF, was negatively correlated with leptin levels (adjusted R2 = 0.27, P &lt
0.01), and EI of the MF was correlated with muscle mass and performance in the timed up-and-go test (adjusted R2 = 0.61, P &lt
0.01). Conclusion: These results suggest that EI might be influenced by specific parameters depending on the location of the muscle.

DOI： 10.1007/s00421-018-3870-7

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Scopus

Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Blackwell Publishing Ltd  

New Findings: What is the central question of this study? Premenopausal women have an attenuated inspiratory muscle metaboreflex-induced increase in arterial blood pressure compared with men. It is unclear whether sympathetic vasomotor outflow during dynamic exercise with increased inspiratory muscle activation is less in young women than in men. What is the main finding and its importance? The magnitude of increased sympathetic vasomotor outflow during leg cycling with inspiratory resistance was smaller in women than in men. Less sympathetic vasomotor outflow with inspiratory muscle metaboreflex activation could be one of the mechanisms for the attenuated inspiratory muscle-induced metaboreflex during exercise in young women. Abstract: We compared changes in muscle sympathetic nerve activity (MSNA) and cardiovascular variables during leg cycle exercise with increased inspiratory muscle resistance in men and women. We hypothesized that sympathetic vasomotor outflow during exercise with increased inspiratory resistance would be attenuated in young women compared with age-matched men. Eight women and seven men completed the study. The subjects performed two 10 min exercise bouts at 40% peak oxygen uptake using a cycle ergometer in a semirecumbent position [spontaneous breathing for 5 min and voluntary hyperventilation with or without inspiratory resistive breathing for 5 min (breathing frequency 50 breaths min−1 with a 50% duty cycle
inspiratory resistance 30% of maximal inspiratory pressure)]. Mean arterial blood pressure (MAP) was acquired using finger photoplethysmography. The MSNA was recorded via microneurography of the right median nerve at the cubital fossa. During leg cycle exercise with inspiratory resistive breathing, MSNA burst frequency was increased, accompanied by an increase in MAP in both men and women. Women, compared with men, had less of an increase in MAP (women +22.8 ± 12.3 mmHg versus men +32.2 ± 5.4 mmHg
P &lt
 0.05) and MSNA burst frequency (women +9.6 ± 2.9 bursts min−1 versus men +14.6 ± 6.4 bursts min−1
P &lt
 0.05). These results suggest that the attenuated inspiratory muscle-induced metaboreflex during exercise in young women is attributable, in part, to a lesser sympathetic vasomotor outflow compared with men.

DOI： 10.1113/EP086817

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Scopus

Language：English   Publishing type：Research paper (scientific journal)  

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.33549/physiolres.933786

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

Older adults requiring long-term care will experience age-associated deterioration of the quality and quantity of skeletal muscle if no interventions are performed. Long-term training is considered a typical intervention method and is effective for improvement of both muscle quantity and physical function. However, how such training affects muscle quality [i.e., fat-to-muscle ratio as determined by echo intensity (EI)] in older adults requiring long-term care remains unclear. The purpose of this study was to investigate the effects of a 12-month physical training intervention on the quality and quantity of skeletal muscle, physical function, and blood chemistry in older adults requiring long-term care. Seventeen older adults requiring long-term care (Tr-group) and 15 healthy older adults (Cont-group) participated in this study. Patients in the Tr-group performed exercises consisting of resistance and endurance training once or twice a week for 12 months. The EI and muscle thickness of the thigh were calculated from the rectus femoris and biceps femoris using B-mode transverse ultrasound images. Physical functions (isometric knee extension peak torque, sit-to-stand test, 5-m normal/maximal speed walking, handgrip strength, and timed up and go test) and blood lipid components including adipocytokines were measured at three points, i.e. baseline and 6 and 12 months after. The thigh EI was significantly lower after 6 months of training than baseline, and it returned to the initial level after 12 months of training (baseline, 70.2 +/- 8.3 a.u.; 6 months, 64.1 +/- 11.2 a.u.; 12 months, 72.3 +/- 7.2 a.u.). The thigh muscle thickness, 5-m maximal speed walking, and knee extension torque were significantly improved after 12 months of training (P &lt; 0.05). The blood chemistry parameters did not significantly change. These results demonstrate that a 12-month training intervention contributes to improvement of muscle quantity and function with tentative changes in muscle quality but has no effect on blood chemistry in older adults requiring long-term care. We conclude that this type of training has the potential to restore the muscle functional abilities of older adults requiring long-term care.

DOI： 10.1016/j.exger.2017.08.036

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：SPRINGER  

Purpose IgG4-related disease is a systemic inflammatory disease characterized by infiltration of IgG4-positive plasma cells into multiple organs, including the pituitary gland. Autoimmunity is thought to be involved in the pathogenesis of IgG4-related disease. The diagnosis of IgG4-related hypophysitis (IgG4-RH) is difficult because its clinical features, such as pituitary swelling and hypopituitarism, are similar to those of other pituitary diseases, including lymphocytic hypophysitis and sellar/suprasellar tumors. The presence and significance of anti-pituitary antibodies (APA) in IgG4-RH is unclear.
Methods In this case-control study, we used single indirect immunofluorescence on human pituitary substrates to assess the prevalence of serum APA in 17 patients with IgG4-RH, 8 control patients with other pituitary diseases (lymphocytic infundibulo-neurohypophysitis, 3; craniopharyngioma, 2; germinoma, 3), and 9 healthy subjects.We further analyzed the endocrine cells targeted by the antibodies using double indirect immunofluorescence.
Results APA were found in 5 of 17 patients with IgG4-RH (29%), and in none of the pituitary controls or healthy subjects. The endocrine cells targeted by the antibodies in the 5 IgG4-RH cases were exclusively corticotrophs. Antibodies were of the IgG1 subclass, rather than IgG4, in all 5 cases, suggesting that IgG4 is not directly involved in the pathogenesis. Finally, antibodies recognized pro-opiomelanocortin in 2 of the cases.
Conclusions Our study suggests that autoimmunity is involved in the pathogenesis of IgG4-RH and that corticotrophs are the main antigenic target, highlighting a possible new diagnostic marker for this condition.

DOI： 10.1007/s11102-016-0780-8

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

BACKGROUND: Exercise train (ET) stimulates muscle response in pathological conditions, including aging. The molecular mechanisms by which exercise improves impaired adiponectin/adiponectin receptor 1 (AdipoR1)-related muscle actions associated with aging are poorly understood. Here we observed that in a senescence-accelerated mouse prone 10 (SAMP10) model, long-term ET modulated muscle-regenerative actions. METHODS: 25-week-old male SAMP10 mice were randomly assigned to the control and the ET (45 min/time, 3/week) groups for 4 months. Mice that were maintained in a sedentary condition served controls. RESULTS: ET ameliorated aging-related muscle changes in microstructure, mitochondria, and performance. The amounts of proteins or mRNAs for p-AMPKα, p-Akt, p-ERK1/2, p-mTOR, Bcl-XL, p-FoxO3, peroxisome proliferators-activated receptor-γ coactivator, adiponectin receptor1 (adpoR1), and cytochrome c oxidase-IV, and the numbers of CD34+ /integrin-α7+ muscle stem cells (MuSCs) and proliferating cells in the muscles and bone-marrow were enhanced by ET, whereas the levels of p-GSK-3α and gp91phox proteins and apoptotic cells were reduced by ET. The ET also resulted in increased levels of plasma adiponectin and the numbers of bone-marrow (BM)-derived circulating CD34+ /integrin-α7+ MuSCs and their functions. Integrin-α7+ MuSCs of exercised mice had improved changes of those beneficial molecules. These ET-mediated aged muscle benefits were diminished by adiponectin and AdipoR1 blocking as well as AMPK inhibition. Finally, recombinant mouse adiponectin enhanced AMPK and mTOR phosphorylations in BM-derived integrin-α7+ cells. CONCLUSIONS: These findings suggest that ET can improve aging-related impairments of BM-derived MuSC regenerative capacity and muscle metabolic alterations via an AMPK-dependent mechanism that is mediated by an adiponectin/AdipoR1 axis in SAMP10 mice.

DOI： 10.1002/jcsm.12166

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PubMed

Language：Japanese   Publisher：LIPPINCOTT WILLIAMS & WILKINS  

DOI： 10.1249/01.mss.0000517506.91015.fc

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Language：Japanese   Publisher：LIPPINCOTT WILLIAMS & WILKINS  

DOI： 10.1249/01.mss.0000517502.68144.4a

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：BIOMED CENTRAL LTD  

Background: Fat infiltration within skeletal muscle is known as intramuscular fat (IMF), which increases with aging. Studies have assessed IMF content, using the mid-thigh as a representative location. However, three-dimensional IMF distribution is not well understood. The aim of this study was to compare the IMF content in young and old adults by assessing its distribution along the length of the thigh.
Methods: Consecutive transaxial images of the right thighs in 15 young (age, 21.0 +/- 0.4) and 15 old (age, 70.7 +/- 3.8) were obtained by magnetic resonance imaging. We measured IMF cross-sectional area (CSA), skeletal muscle CSA and calculated volume-and CSA-based IMF content for the quadriceps femoris (QF), hamstring (HM) and adductor (AD). CSA-based calculations were performed at every 10% of femur length (Lf), with 0% Lf and 100% Lf indicating the proximal and distal ends of femur.
Results: IMF CSAs along the length of the thigh were similar in both age groups. In contrast, skeletal muscle CSAs in all three muscle groups were significantly lower in old adults than in young adults (variation: -15.2 to -1.6 cm(2), P &lt; 0.05). Thus, in volume-based measurements, the older adults had higher IMF contents than the younger adults (9.5% to 14.3% vs. 4.8% to 8.6%, respectively; P &lt; 0.05). However, such age-dependent differences were not observed at the mid-thigh in the QF and AD.
Conclusion: The results demonstrated an age-related increase in IMF content-confirmed in areas of the thigh-primarily based on finding lower amounts of skeletal muscle mass in CSAs in the older adults.

DOI： 10.1186/s12880-017-0185-9

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DOI： doi: 10.1038/ncomms4838

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DOI： DOI: 10.14814/phy2.12070

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DOI： 10.1152/ajpregu.00489.2012.

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DOI： DOI 10.1007/s12199-012-0267-9

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There were no significance correlation between total lymphocyte count and anthropometry measurements, serum albumin, total cholesterol levels, or MNA score, suggesting that TLC is not a suitable marker of malnutrition in the elderly.

Language：English   Publishing type：Research paper (scientific journal)  

The full and short forms of the MNA were useful tools to identify elderly Japanese patients with malnutrition or risk of malnutrition. However, the full MNA cutoff point for malnutrition should be modulated for this population.

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細胞老化(I-1-5;17-22),尿失禁(III-13-1;219-222),失神(III-13-3;225-227)

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Event date： 2021.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：三重(Web開催）   Country：Japan  

Event date： 2021.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：三重(Web開催）   Country：Japan  

Event date： 2021.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：三重(Web開催）   Country：Japan  

Event date： 2021.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：三重(Web開催）   Country：Japan  

Event date： 2021.9

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：三重(Web開催）   Country：Japan  

Event date： 2020.9

Event date： 2020.9

Event date： 2020

Event date： 2020

Event date： 2012

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2012

Language：Japanese  

Country：Japan  

Event date： 2012

Language：Japanese  

Country：Japan  

Event date： 2012

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2012

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2012

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2012

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2011

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2011

Language：English  

Country：Japan  

Event date： 2011

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2011

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2011

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2011

Language：Japanese  

Country：Japan  

Event date： 2011

Language：Japanese  

Country：Japan  

Event date： 2011

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2011

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2011

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2010.11

Language：Japanese  

Country：Japan  

Event date： 2010

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2010

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2010

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2010

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2010

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2010

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Country：Japan  

Event date： 2010

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2009.9

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2009.9

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2009.9

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2009

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2009

Language：English   Presentation type：Oral presentation (general)  

Event date： 2009

Language：Japanese   Presentation type：Oral presentation (general)  

Event date： 2009

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2009

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2008

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2008

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2008

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2008

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2008

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2008

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2008

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2008

Language：Japanese  

Event date： 2008

Language：English   Presentation type：Poster presentation  

Country：Japan  

Event date： 2008

Language：Japanese  

Event date： 2007.9

Language：English   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2007.9

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2007.9

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2007.9

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2007.9

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2007.5

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2007.5

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2007.5

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

李萍、小池晃彦、川田裕樹、押田芳治

Event date： 2007

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2007

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2007

Language：English   Presentation type：Oral presentation (general)  

Event date： 2006

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2006

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2006

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2006

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2006

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2006

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2006

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2006

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 2005.10

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：English   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：English   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2005

Language：English   Presentation type：Oral presentation (general)  

Event date： 2004

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2003

Language：Japanese  

Event date： 2003

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2003

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2003

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2001

Language：English   Presentation type：Poster presentation  

Event date： 2001

Language：English   Presentation type：Oral presentation (invited, special)  

Event date： 2000

Language：English   Presentation type：Oral presentation (invited, special)  

Event date： 1996

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 1996

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 1996

Language：English   Presentation type：Poster presentation  

Event date： 1994

Language：Japanese   Presentation type：Poster presentation  

Country：Japan  

Event date： 1994

Language：English   Presentation type：Poster presentation  

Country：Japan  

Event date： 1993

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 1993

Language：English   Presentation type：Poster presentation  

Event date： 1992

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 1991

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 1991

Language：English   Presentation type：Poster presentation  

Event date： 1991

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 1990

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 1990

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 1990

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Country：Japan  

Event date： 1989

Language：Japanese   Presentation type：Oral presentation (general)  

Country：Japan  

修士コースであるYLPでの生活習慣に関する講義

生活習慣病に関する講義の一コマを担当

10月から3月まで、半年にわたって基礎研究を指導し、発表を行う。