Updated on 2024/03/11

写真a

 
KOIKE, Teruhiko
 
Organization
Research Center of Health, Physical Fitness and Sports Division of Health Science Professor
Graduate School
Graduate School of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 1994.3   岐阜大学 ) 

Research Interests 8

  1. 細胞内シグナル伝達

  2. 高齢者の栄養

  3. サルコペニア

  4. スポーツ医学

  5. 高齢者の栄養

  6. マトリックスメタロプロテアーゼ

  7. サルコペニア

  8. 細胞内シグナル伝達

Research Areas 1

  1. Others / Others  / Applied Health Sciences

Current Research Project and SDGs 3

  1. サルコペニアとフレイル

  2. 運動、栄養が健康特に老化に及ぼす影響

  3. インスリン抵抗性の制御機構

Research History 14

  1. 名古屋大学総合保健体育科学センター    保健科学部   教授

    2015.4

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    Country:Japan

  2. Nagoya University   Research Center of Health, Physical Fitness and Sports, Division of Health Science   Professor

    2015.4

  3. Nagoya University   Research Center of Health, Physical Fitness and Sports Division of Health Science   Professor

    2015.4

  4. 名古屋大学総合保健体育科学センター     保健科学部   准教授

    2007.4 - 2014.3

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    Country:Japan

  5. 名古屋大学総合保健体育科学センター 助教授

    2005.4 - 2006.3

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    Country:Japan

  6. 名古屋大学総合保健体育科学センター助手

    2004.5 - 2005.3

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    Country:Japan

  7. 名古屋大学医学系研究科講師

    2003.4 - 2004.3

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    Country:Japan

  8. 名古屋大学医学部老年科医員

    2002.4 - 2004.4

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    Country:Japan

  9. NIH Post-doctoral trainee(Genetic approaches to aging grant)

    2001 - 2002.3

  10. 長寿科学振興財団派遣研究員

    1999.10 - 2000.3

  11. 日本赤十字愛知短期大学非常勤講師

    1998 - 1999

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    Country:Japan

  12. 名古屋大学医学部老年科医員

    1997.1 - 1999.10

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    Country:Japan

  13. 名古屋大学医学部生態防御研究施設(分子病態研究部門)助手

    1994.4 - 1996.12

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    Country:Japan

  14. 天理よろづ相談所病院ジュニアレジデント

    1988.4 - 1990.3

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    Country:Japan

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Education 2

  1. Gifu University   Graduate School, Division of Medicine   biochemistry

    1990.4 - 1994.3

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    Country: Japan

  2. Gifu University   Faculty of Medicine   Medicine

    1981.4 - 1988.3

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    Country: Japan

Professional Memberships 8

  1. 日本内科学会   内科学会東海支部評議員

    2007.4 - 2008.3

  2. 日本老年医学会   評議員

    2005.4

  3. 日本老年医学会

    2005.4

  4. 日本体力医学会

  5. 日本糖尿病学会

  6. 日本糖尿病学会

  7. 日本内科学会

  8. 日本体力医学会

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Committee Memberships 3

  1. 安全保障委員会   安全保障委員会委員  

    2020   

  2. 安全保障委員会   安全保障委員会委員  

    2020   

  3. 全学動物実験委員会   全学動物実験委員  

    2005   

Awards 1

  1. 岐阜医学奨励賞

    1993   岐阜大学  

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    Country:Japan

 

Papers 117

  1. Factors Related To Trunk Intramuscular Adipose Tissue Content - Comparison Of Younger And Older Men

    Kitagawa Funa, Tanaka Noriko, Ogawa Madoka, Yoshiko Akito, Oshida Yoshiharu, Koike Teruhiko, Akima Hiroshi

    MEDICINE & SCIENCE IN SPORTS & EXERCISE   Vol. 54 ( 9 ) page: 530 - 530   2022.9

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  2. The Relationship Between Serum Igf-1 And Fat Deposition Of Thigh In Younger And Older Men

    Ogawa Madoka, Tanaka Noriko, Yoshiko Akito, Oshida Yoshiharu, Koike Teruhiko, Akima Hiroshi

    MEDICINE & SCIENCE IN SPORTS & EXERCISE   Vol. 54 ( 9 ) page: 529 - 529   2022.9

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  3. Relationships Between Skeletal Muscle Lipids And Muscle Functional Performances In Older Individuals

    Yoshiko Akito, Maeda Hisashi, Takahashi Hideyuki, Koike Teruhiko, Tanaka Noriko I., Akima Hiroshi

    MEDICINE & SCIENCE IN SPORTS & EXERCISE   Vol. 54 ( 9 ) page: 531 - 531   2022.9

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  4. Importance of skeletal muscle lipid levels for muscle function and physical function in older individuals

    Yoshiko Akito, Maeda Hisashi, Takahashi Hideyuki, Koike Teruhiko, Tanaka Noriko, Akima Hiroshi

    APPLIED PHYSIOLOGY NUTRITION AND METABOLISM   Vol. 47 ( 6 ) page: 649 - 658   2022.6

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    Language:Japanese  

    DOI: 10.1139/apnm-2021-0685

    Web of Science

  5. Combined effects of exercise training and D-allulose intake on endurance capacity in mice. International journal

    Takamasa Tsuzuki, Ryo Suzuki, Risa Kajun, Takako Yamada, Tetsuo Iida, Bingyang Liu, Teruhiko Koike, Yukiyasu Toyoda, Takayuki Negishi, Kazunori Yukawa

    Physiological reports   Vol. 10 ( 9 ) page: e15297   2022.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    This study investigated the combined effects of exercise training and D-allulose intake on endurance capacity in mice. Male C57BL/6J mice were fed either a control diet (Con) or a 3% D-allulose diet (Allu) and further divided into the sedentary (Sed) or exercise training (Ex) groups (Con-Sed, Con-Ex, Allu-Sed, Allu-Ex, respectively; n = 6-7/group). The mice in the Ex groups were trained on a motor-driven treadmill 5 days/week for 4 weeks (15-18 m/min, 60 min). After the exercise training period, all mice underwent an exhaustive running test to assess their endurance capacity. At 48 h after the running test, the mice in the Ex groups were subjected to run at 18 m/min for 60 min again. Then the gastrocnemius muscle and liver were sampled immediately after the exercise bout. The running time until exhaustion tended to be higher in the Allu-Ex than in the Con-Ex group (p = 0.08). The muscle glycogen content was significantly lower in the Con-Ex than in the Con-Sed group and was significantly higher in the Allu-Ex than in the Con-Ex group (p < 0.05). Moreover, exercise training increased the phosphorylation levels of adenosine monophosphate-activated protein kinase (AMPK) in the muscle and liver. The phosphorylation levels of acetyl coenzyme A carboxylase (ACC), a downstream of AMPK, in the muscle and liver were significantly higher in the Allu-Ex than in the Con-Sed group (p < 0.05), suggesting that the combination of exercise training and D-allulose might have activated the AMPK-ACC signaling pathway, which is associated with fatty acid oxidation in the muscle and liver. Taken together, our data suggested the combination of exercise training and D-allulose intake as an effective strategy to upregulate endurance capacity in mice. This may be associated with sparing glycogen content and enhancing activation of AMPK-ACC signaling in the skeletal muscle.

    DOI: 10.14814/phy2.15297

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    PubMed

  6. Contribution of skeletal muscle and serum lipids to muscle contraction induced by neuromuscular electrical stimulation in older individuals

    Akito Yoshiko, Hisashi Maeda, Hideyuki Takahashi, Teruhiko Koike, Noriko Tanaka, Hiroshi Akima

    Physiological Reports   Vol. 10 ( 6 )   2022.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.14814/phy2.15236

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.14814/phy2.15236

  7. d-Allulose Improves Endurance and Recovery from Exhaustion in Male C57BL/6J Mice. International journal

    Bingyang Liu, Yang Gou, Takamasa Tsuzuki, Takako Yamada, Tetsuo Iida, Sixian Wang, Ryoichi Banno, Yukiyasu Toyoda, Teruhiko Koike

    Nutrients   Vol. 14 ( 3 )   2022.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    d-Allulose, a rare sugar, improves glucose metabolism and has been proposed as a candidate calorie restriction mimetic. This study aimed to investigate the effects of d-allulose on aerobic performance and recovery from exhaustion and compared them with the effects of exercise training. Male C57BL/6J mice were subjected to exercise and allowed to run freely on a wheel. Aerobic performance was evaluated using a treadmill. Glucose metabolism was analyzed by an intraperitoneal glucose tolerance test (ipGTT). Skeletal muscle intracellular signaling was analyzed by Western blotting. Four weeks of daily oral administration of 3% d-allulose increased running distance and shortened recovery time as assessed by an endurance test. d-Allulose administration also increased the maximal aerobic speed (MAS), which was observed following treatment for &gt;3 or 7 days. The improved performance was associated with lower blood lactate levels and increased liver glycogen levels. Although d-allulose did not change the overall glucose levels as determined by ipGTT, it decreased plasma insulin levels, indicating enhanced insulin sensitivity. Finally, d-allulose enhanced the phosphorylation of AMP-activated protein kinase and acetyl-CoA carboxylase and the expression of peroxisome proliferator-activated receptor γ coactivator 1α. Our results indicate that d-allulose administration enhances endurance ability, reduces fatigue, and improves insulin sensitivity similarly to exercise training. d-Allulose administration may be a potential treatment option to alleviate obesity and enhance aerobic exercise performance.

    DOI: 10.3390/nu14030404

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    PubMed

  8. The Neural Correlates of Semantic and Grammatical Encoding During Sentence Production in a Second Language: Evidence From an fMRI Study Using Structural Priming

    Nakagawa Eri, Koike Takahiko, Sumiya Motofumi, Shimada Koji, Makita Kai, Yoshida Haruyo, Yokokawa Hirokazu, Sadato Norihiro

    FRONTIERS IN HUMAN NEUROSCIENCE   Vol. 15   2022.1

  9. Relationship between adiponectin and intramuscular fat content determined by ultrasonography in older adults

    Maya Hioki, Nana Kanehira, Teruhiko Koike, Akira Saito, Kiyoshi Shimaoka, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima

    PLOS ONE   Vol. 17 ( 1 ) page: e0262271 - e0262271   2022.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science (PLoS)  

    Age-associated intramuscular adipose tissue (IntraMAT) deposition induces the development of insulin resistance and metabolic syndrome. However, the relationship between IntraMAT and biochemical parameters in older adults remains unclear. The purpose of this study, therefore, was to elucidate the relationship between adiponectin and echo intensity–estimated IntraMAT using ultrasonography in normal-weight older adults (men 9, women 13) and examine biochemical parameters. Blood tests were performed to determine fasting levels of glucose, insulin, hemoglobin A1c, total cholesterol (Total-C), high-density-lipoprotein cholesterol, low-density-lipoprotein cholesterol (LDL-C), free fatty acid, triglycerides (TGs), adiponectin, leptin, high-sensitivity C-reactive protein, and high-sensitivity tumor necrosis factor, and homoeostasis model assessment index of insulin resistance (HOMA-IR). Mean gray-scale echo intensity was calculated as the IntraMAT index of the vastus lateralis. Waist circumference was measured at the level of the navel as the visceral adipose tissue (VAT) index. Echo intensity was significantly inversely correlated with adiponectin or LDL-C, and that was significantly positively correlated with TG. Adiponectin level was inversely correlated with waist circumference. Partial correlation analysis with waist circumference as the control variable revealed that adiponectin was inversely correlated with echo intensity, independent of waist circumference, whereas no such correlation was observed after controlling for LDL-C and TG levels. When biochemical parameters were grouped in the principal component analysis, among men, Total-C, insulin, and HOMA-IR or hemoglobin A1c, and high-sensitivity tumor necrosis factor–alpha were grouped with the same distribution for factors 1 and 2. Among women, glucose, insulin, HOMA-IR, and Total-C or TGs were grouped with the same distribution for factors 1 and 2. These data suggest that adiponectin level is related to IntraMAT content, independent of VAT in normal-weight older adults. The dynamics of adiponectin might not be similar to those of other circulating biochemical parameters in older men and women.

    DOI: 10.1371/journal.pone.0262271

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  10. Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis. International journal

    Akihiro Ryuge, Tomoki Kosugi, Kayaho Maeda, Ryoichi Banno, Yang Gou, Kei Zaitsu, Takanori Ito, Yuka Sato, Akiyoshi Hirayama, Shoma Tsubota, Takashi Honda, Kazuki Nakajima, Tomoya Ozaki, Kunio Kondoh, Kazuo Takahashi, Noritoshi Kato, Takuji Ishimoto, Tomoyoshi Soga, Takahiko Nakagawa, Teruhiko Koike, Hiroshi Arima, Yukio Yuzawa, Yasuhiko Minokoshi, Shoichi Maruyama, Kenji Kadomatsu

    JCI insight   Vol. 6 ( 20 )   2021.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Monocarboxylates, such as lactate and pyruvate, are precursors for biosynthetic pathways, including those for glucose, lipids, and amino acids via the tricarboxylic acid (TCA) cycle and adjacent metabolic networks. The transportation of monocarboxylates across the cellular membrane is performed primarily by monocarboxylate transporters (MCTs), the membrane localization and stabilization of which are facilitated by the transmembrane protein basigin (BSG). Here, we demonstrate that the MCT/BSG axis sits at a crucial intersection of cellular metabolism. Abolishment of MCT1 in the plasma membrane was achieved by Bsg depletion, which led to gluconeogenesis impairment via preventing the influx of lactate and pyruvate into the cell, consequently suppressing the TCA cycle. This net anaplerosis suppression was compensated in part by the increased utilization of glycogenic amino acids (e.g., alanine and glutamine) into the TCA cycle and by activated ketogenesis through fatty acid β-oxidation. Complementary to these observations, hyperglycemia and hepatic steatosis induced by a high-fat diet were ameliorated in Bsg-deficient mice. Furthermore, Bsg deficiency significantly improved insulin resistance induced by a high-fat diet. Taken together, the plasma membrane-selective modulation of lactate and pyruvate transport through BSG inhibition could potentiate metabolic flexibility to treat metabolic diseases.

    DOI: 10.1172/jci.insight.142464

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  11. Relationship between physical activity time and intramuscular adipose tissue content of the thigh muscle groups of younger and older men

    Ogawa Madoka, Tanaka Noriko, Yoshiko Akito, Oshida Yoshiharu, Koike Teruhiko, Akima Hiroshi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 )   2021.10

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  12. d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats. International journal

    Yang Gou, Bingyang Liu, Mengyao Cheng, Takako Yamada, Tetsuo Iida, Sixian Wang, Ryoichi Banno, Teruhiko Koike

    Molecules (Basel, Switzerland)   Vol. 26 ( 20 )   2021.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: d-Allulose is a rare sugar with antiobesity and antidiabetic activities. However, its direct effect on insulin sensitivity and the underlying mechanism involved are unknown. OBJECTIVE: This study aimed to investigate the effect of d-allulose on high-fat diet (HFD)-induced insulin resistance using the hyperinsulinemic-euglycemic (HE)-clamp method and intramuscular signaling analysis. METHODS: Wistar rats were randomly divided into three dietary groups: chow diet, HFD with 5% cellulose (HFC), and HFD with 5% d-allulose (HFA). After four weeks of feeding, the insulin tolerance test (ITT), intraperitoneal glucose tolerance test (IPGTT), and HE-clamp study were performed. The levels of plasma leptin, adiponectin, and tumor necrosis factor (TNF)-α were measured using the enzyme-linked immunosorbent assay. We analyzed the levels of cell signaling pathway components in the skeletal muscle using Western blotting. RESULTS: d-allulose alleviated the increase in HFD-induced body weight and visceral fat and reduced the area under the curve as per ITT and IPGTT. d-Allulose increased the glucose infusion rate in the two-step HE-clamp test. Consistently, the insulin-induced phosphorylation of serine 307 in the insulin receptor substrate-1 and Akt and expression of glucose transporter 4 (Glut-4) in the muscle were higher in the HFA group than HFC group. Furthermore, d-allulose decreased plasma TNF-α concentration and insulin-induced phosphorylation of stress-activated protein kinase/Jun N-terminal kinase in the muscle and inhibited adiponectin secretion in HFD-fed rats. CONCLUSIONS: d-allulose improved HFD-induced insulin resistance in Wistar rats. The reduction of the proinflammatory cytokine production, amelioration of adiponectin secretion, and increase in insulin signaling and Glut-4 expression in the muscle contributed to this effect.

    DOI: 10.3390/molecules26206310

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    PubMed

  13. Investigation of D-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats

    Natsume Yukie, Yamada Takako, Iida Tetsuo, Ozaki Nobuaki, Gou Yang, Oshida Yoshiharu, Koike Teruhiko

    HELIYON   Vol. 7 ( 9 )   2021.9

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  14. Effect of electromyostimulation on intramyocellular lipids of the vastus lateralis in older adults: a randomized controlled trial

    Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Takahashi Hideyuki, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

    BMC MUSCULOSKELETAL DISORDERS   Vol. 22 ( 1 )   2021.6

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  15. Effect of elbow joint angles on electromyographic activity versus force relationships of synergistic muscles of the triceps brachii

    Akima Hiroshi, Maeda Hisashi, Koike Teruhiko, Ishida Koji

    PLOS ONE   Vol. 16 ( 6 )   2021.6

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  16. Eicosapentaenoic acid enhances skeletal muscle hypertrophy without altering the protein anabolic signaling pathway. Reviewed

    Siriguleng, T. Koike, Y. Natsume, H. Jiang, L. Mu, Y. Oshida

    Physiol Res   Vol. 70 ( 1 ) page: 55 - 65   2021.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.33549/physiolres.934534

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  17. Comparison Of Fascicle Behaviors Between Superficial And Deeper Muscles Of Triceps Brachii During Isometric Contractions

    Akima Hiroshi, Maeda Hisashi, Koike Teruhiko, Ishida Koji, Ando Ryosuke

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   Vol. 52 ( 17 ) page: 946 - 946   2020.7

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    Language:Japanese  

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  18. Comparison Of Fascicle Behaviors Between Superficial And Deeper Muscles Of Triceps Brachii During Isometric Contractions

    Akima Hiroshi, Maeda Hisashi, Koike Teruhiko, Ishida Koji, Ando Ryosuke

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   Vol. 52 ( 17 ) page: 946 - 946   2020.7

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  19. Age-related changes in muscle volume and intramuscular fat content in quadriceps femoris and hamstrings

    Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

    EXPERIMENTAL GERONTOLOGY   Vol. 132   2020.4

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  20. Electromyostimulation Induced Changes In Intramyocellular Lipid Of Vastus Lateralis In Older Adults

    Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Takahashi Hideyuki, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   Vol. 51 ( 6 ) page: 717 - 717   2019.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

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  21. Electromyostimulation Induced Changes In Intramyocellular Lipid Of Vastus Lateralis In Older Adults

    Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Takahashi Hideyuki, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   Vol. 51 ( 6 ) page: 717 - 717   2019.6

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  22. Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults. International journal

    Akito Yoshiko, Kana Shiozawa, Shiori Niwa, Hideyuki Takahashi, Teruhiko Koike, Kohei Watanabe, Keisho Katayama, Hiroshi Akima

    GeroScience   Vol. 46 ( 1 ) page: 517 - 530   2024.2

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    Muscle function and exercise performance measures, such as muscle endurance capacity, maximal strength, chair stand score, gait speed, and Timed Up and Go score, are evaluated to diagnose sarcopenia and frailty in older individuals. Furthermore, intramuscular adipose tissue (IntraMAT) content increases with age. Skeletal muscle oxidative capacity determines muscle metabolism and maintains muscle performance. This study aimed to investigate the association of skeletal muscle oxidative capacity with muscle function, exercise performance, and IntraMAT content in older individuals. Thirteen older men and women participated in this study. Skeletal muscle oxidative capacity was assessed by the recovery speed of muscle oxygen saturation after exercise using near-infrared spectroscopy from the medial gastrocnemius. We assessed two muscle functions, peak torque and time to task failure, and four sarcopenia-related exercise performances: handgrip strength, gait speed, 30-s chair stand, and Timed Up and Go. The IntraMAT content was measured using axial magnetic resonance imaging. The results showed a relationship between skeletal muscle oxidative capacity and gait speed but not with muscle functions and other exercise performance measures. Skeletal muscle oxidative capacity was not related to IntraMAT content. Skeletal muscle oxidative capacity, which may be indicative of the capacity of muscle energy production in the mitochondria, is related to locomotive functions but not to other functional parameters or skeletal fat infiltration.

    DOI: 10.1007/s11357-023-01043-6

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    PubMed

  23. Factors related to trunk intramuscular adipose tissue content - A comparison of younger and older men. Reviewed International journal

    Funa Kitagawa, Madoka Ogawa, Akito Yoshiko, Yoshiharu Oshida, Teruhiko Koike, Hiroshi Akima, Noriko I Tanaka

    Experimental gerontology   Vol. 168   page: 111922 - 111922   2022.10

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    The present study investigated factors related to trunk intramuscular adipose tissue (IntraMAT) content in younger and older men. Twenty-three healthy younger (20 to 29 years) and 20 healthy older men (63 to 79 years) participated in this study. The trunk IntraMAT content was measured using magnetic resonance imaging at the height of the 3rd lumbar vertebra. In addition to blood properties and physical performance, dietary intake was assessed by a self-administered diet history questionnaire. The dietary intake status was quantified using the nutrient adequacy score for the intake of 10 selected nutrients by summing the number of items that met the criteria of dietary reference intakes for Japanese individuals. The results obtained revealed that the trunk IntraMAT content was significantly higher in the older group than in the younger group (p < 0.05). In the younger group, the trunk IntraMAT content significantly correlated with systolic and diastolic blood pressure and HbA1c (rs = 0.443 to 0.464, p < 0.05). In the older group, significant and negative correlations were observed between the trunk IntraMAT content and 5-m usual walking speed, handgrip strength, and nutrient adequacy scores (rs = -0.485 to -0.713, p < 0.05). These results indicate that factors associated with the trunk IntraMAT content differed in an age dependent manner. In the younger group, the trunk IntraMAT content correlated with the metabolic status such as blood pressure and HbA1c. In the older group, physical performance and the dietary intake status negatively correlated with the trunk IntraMAT content.

    DOI: 10.1016/j.exger.2022.111922

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    PubMed

  24. Eicosapentaenoic acid enhances skeletal muscle hypertrophy without altering the protein anabolic signaling pathway. Reviewed

    Siriguleng, T. Koike, Y. Natsume, H. Jiang, L. Mu, Y. Oshida.

    Physiol Res   Vol. 17 ( 70(1) ) page: 55 - 65   2021.3

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  25. Comparison of fascicle behaviors between superficial and deeper muscles of triceps brachii during isometric contractions Reviewed

    Hiroshi Akima, Hisashi Maeda, Teruhiko Koike, Koji Ishida, Ryosuke Ando

    Journal of Electromyography and Kinesiology   Vol. 54   page: 102452 - 102452   2020.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.jelekin.2020.102452

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  26. Comparing intramuscular adipose tissue on T1-weighted and two-point Dixon images Reviewed International journal

    Madoka Ogawa, Akito Yoshiko, Noriko Tanaka, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima

    PLoS One   Vol. 15 ( 4 )   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0231156

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  27. Muscle deoxygenation and neuromuscular activation in synergistic muscles during intermittent exercise under hypoxic conditions. Reviewed

    Yoshiko A, Katayama K, Ishida K, Ando R, Koike T, Oshida Y, Akima H

    Scientific Reports   Vol. 10 ( 1 )   2020.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-019-57099-y

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  28. HIGHER AND LOWER MUSCLE ECHO INTENSITY IN ELDERLY INDIVIDUALS IS DISTINGUISHED BY MUSCLE SIZE, PHYSICAL PERFORMANCE AND DAILY PHYSICAL ACTIVITY

    Yoshiko Akito, Natsume Yukie, Makino Taeko, Hayashi Takahiro, Umegaki Hiroyuki, Yoshida Yasuko, Cheng Xian Wu, Kuzuya Masafumi, Ishida Koji, Koike Teruhiko, Oshida Yoshiharu, Akima Hiroshi

    ULTRASOUND IN MEDICINE AND BIOLOGY   Vol. 45 ( 9 ) page: 2372 - 2380   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    This study was performed to identify factors that discriminate muscle echo intensity (EI) among parameters of body composition, physical function and daily physical activity in elderly individuals. A total of 209 men and women (73.7 +/- 2.8 y) were evaluated. EI was measured on ultrasonographic axial thigh muscle images. The participants were categorized into the low, mid and high EI groups. We measured the skeletal muscle mass index (SMI) and physical functions. The high EI group exhibited a significantly lower SMI, slower 5-m walking time and shorter 6-min walking distance than the low EI group and had a shorter moderate-intensity activity time than the mid EI group. As a result of the discriminant analysis, elderly individuals were categorized into EI groups by SMI, daily activity and physical function. The data indicate that morphologic and functional parameters and the daily activity level help to discriminate higher and lower muscle EI. (C) 2019 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

    DOI: 10.1016/j.ultrasmedbio.2019.05.029

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  29. Twenty-four months’ resistance and endurance training improves muscle size and physical functions but not muscle quality in older adults requiring long-term care. Reviewed

    Yoshiko A, Kaji T, Sugiyama H, Koike T, Oshida Y, Akima H

    The Journal of Nutrition, Health & Aging   Vol. 23 ( 6 ) page: 564 - 570   2019.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12603-019-1208-8

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  30. Relationship between physical activity and intramyocellular lipid content is different between young and older adults

    Hioki Maya, Kanehira Nana, Koike Teruhiko, Saito Akira, Takahashi Hideyuki, Shimaoka Kiyoshi, Sakakibara Hisataka, Oshida Yoshiharu, Akima Hiroshi

    EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY   Vol. 119 ( 1 ) page: 113 - 122   2019.1

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    DOI: 10.1007/s00421-018-4005-x

    Web of Science

  31. Effects of 10-week walking and walking with home-based resistance training on muscle quality, muscle size, and physical functional tests in healthy older individuals. Reviewed

    Yoshiko A, Tomita A, Ando R, Ogawa M, Kondo S, Saito A, Tanaka N.I, Koike T, Oshida Y, Akima H

    European Review of Aging and Physical Activity   Vol. 15 ( 13 )   2018.11

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    DOI: 10.1186/s11556-018-0201-2

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  32. Effects of post-fracture non-weight-bearing immobilization on muscle atrophy, intramuscular and intermuscular adipose tissues in the thigh and calf Reviewed

    Akito Yoshiko, Koun Yamauchi, Takayuki Kato, Koji Ishida, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima

    Skeletal Radiology   Vol. 47 ( 11 ) page: 1541 - 1549   2018.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Springer Verlag  

    Objective: Disuse and/or a non-weight-bearing condition changes muscle composition, with decreased skeletal muscle tissue and increased fat within (intramuscular adipose tissue, IntraMAT) and between (intermuscular adipose tissue, InterMAT) given muscles. Excessive adipose tissue contributes to dysfunctional and metabolically impaired muscle. How these adipose tissues change during orthopedic treatment (e.g., cast immobilization, daily use of crutches) is not well documented. This study aimed to quantify changes in IntraMAT, InterMAT, and thigh and calf muscle tissue during orthopedic treatment. Materials and methods: We studied 8 patients with fifth metatarsal bone or fibular fractures. The ankle joint involved underwent plaster casting for approximately 4 weeks, with crutches used during that time. Axial T1-weighted MRI at the mid-thigh and a 30% proximal site at the calf were obtained to measure IntraMAT and InterMAT cross-sectional areas (CSAs) and skeletal muscle tissue CSA before treatment and 4 weeks afterward. Results: Thigh and calf muscle tissue CSAs were significantly decreased from before to after treatment: thigh, 85.8 ± 7.6 to 77.1 ± 7.3 cm2
    calf, 53.3 ± 5.5 to 48.9 ± 5.0 cm2 (p &lt
    0.05). None of the IntraMAT or InterMAT changes was statistically significant. There was a relation between the percentage change of thigh IntraMAT CSA and muscle tissue CSA (rs = −0.86, p &lt
    0.01). Conclusions: The 4 weeks of treatment primarily induced skeletal muscle atrophy with less of an effect on IntraMAT or InterMAT. There is a risk of increasing IntraMAT relatively by decreasing skeletal muscle tissue size during orthopedic treatment.

    DOI: 10.1007/s00256-018-2985-6

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    Scopus

  33. Muscle quality characteristics of muscles in the thigh, upper arm and lower back in elderly men and women Reviewed

    Akito Yoshiko, Takashi Kaji, Hiroki Sugiyama, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima

    European Journal of Applied Physiology   Vol. 118 ( 7 ) page: 1385 - 1395   2018.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Springer Verlag  

    Purpose: The ratio of fat within skeletal muscle is an important parameter that is indicative of muscle quality, and can be assessed using ultrasonography to measure echo intensity (EI). Muscle EI indicates muscle strength and risk of physical dysfunction
    however, this observation was determined following examinations of only selected muscle. The purpose of this study was to investigate the EI characteristics of muscles in several regions in elderly men and women, using physical function tests and serum cholesterol levels. Methods: Twenty-two men and women (age 78 ± 8 years) participated in this study. The EIs were calculated from rectus femoris (RF), biceps femoris (BF) triceps brachii (TB) and multifidus (MF) using B-mode transverse ultrasound images. Seven functional tests (isometric knee-extension peak torque, functional reach, sit-to-stand, 5-m normal/maximal speed walking, handgrip strength and timed up-and-go) and blood lipid components including adipocytokines were measured in all participants. Results: A statistically significant correlation between EI of the RF, TB and BF was observed (r = 0.46–0.50, P &lt
    0.05), but not between EI of the MF and that of other muscles. EI of muscles of the limbs, which was averaged EI for RF, TB and BF, was negatively correlated with leptin levels (adjusted R2 = 0.27, P &lt
    0.01), and EI of the MF was correlated with muscle mass and performance in the timed up-and-go test (adjusted R2 = 0.61, P &lt
    0.01). Conclusion: These results suggest that EI might be influenced by specific parameters depending on the location of the muscle.

    DOI: 10.1007/s00421-018-3870-7

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    Scopus

  34. Effects Of 24 Months Resistance And Endurance Training On Muscle Quality, Quantity And Physical Functions In Elderly With Long-term Care

    Yoshiko Akito, Kaji Takashi, Sugiyama Hiroki, Koike Teruhiko, Oshida Yoshiharu, Akima Hiroshi

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   Vol. 50 ( 5 ) page: 209-209   2018.5

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  35. Blunted Sympathetic Vasomotor Outflow To Inspiratory Resistive Breathing During Exercise In Women Compared to Men

    Katayama Keisho, Smith Joshua R., Goto Kanako, Shimizu Kaori, Saito Mitsuru, Ishida Koji, Koike Teruhiko, Iwase Satoshi, Harms Craig A.

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   Vol. 50 ( 5 ) page: 284-285   2018.5

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    Web of Science

  36. Blunted Sympathetic Vasomotor Outflow To Inspiratory Resistive Breathing During Exercise In Women Compared to Men

    Katayama Keisho, Smith Joshua R, Goto Kanako, Shimizu Kaori, Saito Mitsuru, Ishida Koji, Koike Teruhiko, Iwase Satoshi, Harms Craig A

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   Vol. 50 ( 5 ) page: 284-285   2018.5

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  37. Effects Of 24 Months Resistance And Endurance Training On Muscle Quality, Quantity And Physical Functions In Elderly With Long-term Care

    Yoshiko Akito, Kaji Takashi, Sugiyama Hiroki, Koike Teruhiko, Oshida Yoshiharu, Akima Hiroshi

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   Vol. 50 ( 5 ) page: 209-209   2018.5

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  38. Elevated sympathetic vasomotor outflow in response to increased inspiratory muscle activity during exercise is less in young women compared with men Reviewed

    Keisho Katayama, Joshua R. Smith, Kanako Goto, Kaori Shimizu, Mitsuru Saito, Koji Ishida, Teruhiko Koike, Satoshi Iwase, Craig A. Harms

    Experimental Physiology   Vol. 103 ( 4 ) page: 570 - 580   2018.4

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    New Findings: What is the central question of this study? Premenopausal women have an attenuated inspiratory muscle metaboreflex-induced increase in arterial blood pressure compared with men. It is unclear whether sympathetic vasomotor outflow during dynamic exercise with increased inspiratory muscle activation is less in young women than in men. What is the main finding and its importance? The magnitude of increased sympathetic vasomotor outflow during leg cycling with inspiratory resistance was smaller in women than in men. Less sympathetic vasomotor outflow with inspiratory muscle metaboreflex activation could be one of the mechanisms for the attenuated inspiratory muscle-induced metaboreflex during exercise in young women. Abstract: We compared changes in muscle sympathetic nerve activity (MSNA) and cardiovascular variables during leg cycle exercise with increased inspiratory muscle resistance in men and women. We hypothesized that sympathetic vasomotor outflow during exercise with increased inspiratory resistance would be attenuated in young women compared with age-matched men. Eight women and seven men completed the study. The subjects performed two 10 min exercise bouts at 40% peak oxygen uptake using a cycle ergometer in a semirecumbent position [spontaneous breathing for 5 min and voluntary hyperventilation with or without inspiratory resistive breathing for 5 min (breathing frequency 50 breaths min−1 with a 50% duty cycle
    inspiratory resistance 30% of maximal inspiratory pressure)]. Mean arterial blood pressure (MAP) was acquired using finger photoplethysmography. The MSNA was recorded via microneurography of the right median nerve at the cubital fossa. During leg cycle exercise with inspiratory resistive breathing, MSNA burst frequency was increased, accompanied by an increase in MAP in both men and women. Women, compared with men, had less of an increase in MAP (women +22.8 ± 12.3 mmHg versus men +32.2 ± 5.4 mmHg
    P &lt
     0.05) and MSNA burst frequency (women +9.6 ± 2.9 bursts min−1 versus men +14.6 ± 6.4 bursts min−1
    P &lt
     0.05). These results suggest that the attenuated inspiratory muscle-induced metaboreflex during exercise in young women is attributable, in part, to a lesser sympathetic vasomotor outflow compared with men.

    DOI: 10.1113/EP086817

    Web of Science

    Scopus

  39. Effect of acupuncture at acupoint of Shenshu (BL 23) on the bones of ovariectomized rats Reviewed

    Takeda Atsushi, Koike Teruhiko, Urata Shigeru, Ishida Torao, Oshida Yoshiharu

    JOURNAL OF TRADITIONAL CHINESE MEDICINE   Vol. 38 ( 1 ) page: 54-60   2018.2

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  40. Effect of Prior Chronic Aerobic Exercise on Overload-Induced Skeletal Muscle Hypertrophy in Mice

    Siriguleng, Koike T, Natsume Y, Iwama S, Oshida Y

    PHYSIOLOGICAL RESEARCH   Vol. 67 ( 5 ) page: 765 - 775   2018

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    DOI: 10.33549/physiolres.933786

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  41. Effect of 12-month resistance and endurance training on quality, quantity, and function of skeletal muscle in older adults requiring long-term care Reviewed

    Akito Yoshiko, Takashi Kaji, Hiroki Sugiyama, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima

    EXPERIMENTAL GERONTOLOGY   Vol. 98   page: 230 - 237   2017.11

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    Older adults requiring long-term care will experience age-associated deterioration of the quality and quantity of skeletal muscle if no interventions are performed. Long-term training is considered a typical intervention method and is effective for improvement of both muscle quantity and physical function. However, how such training affects muscle quality [i.e., fat-to-muscle ratio as determined by echo intensity (EI)] in older adults requiring long-term care remains unclear. The purpose of this study was to investigate the effects of a 12-month physical training intervention on the quality and quantity of skeletal muscle, physical function, and blood chemistry in older adults requiring long-term care. Seventeen older adults requiring long-term care (Tr-group) and 15 healthy older adults (Cont-group) participated in this study. Patients in the Tr-group performed exercises consisting of resistance and endurance training once or twice a week for 12 months. The EI and muscle thickness of the thigh were calculated from the rectus femoris and biceps femoris using B-mode transverse ultrasound images. Physical functions (isometric knee extension peak torque, sit-to-stand test, 5-m normal/maximal speed walking, handgrip strength, and timed up and go test) and blood lipid components including adipocytokines were measured at three points, i.e. baseline and 6 and 12 months after. The thigh EI was significantly lower after 6 months of training than baseline, and it returned to the initial level after 12 months of training (baseline, 70.2 +/- 8.3 a.u.; 6 months, 64.1 +/- 11.2 a.u.; 12 months, 72.3 +/- 7.2 a.u.). The thigh muscle thickness, 5-m maximal speed walking, and knee extension torque were significantly improved after 12 months of training (P &lt; 0.05). The blood chemistry parameters did not significantly change. These results demonstrate that a 12-month training intervention contributes to improvement of muscle quantity and function with tentative changes in muscle quality but has no effect on blood chemistry in older adults requiring long-term care. We conclude that this type of training has the potential to restore the muscle functional abilities of older adults requiring long-term care.

    DOI: 10.1016/j.exger.2017.08.036

    Web of Science

  42. Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis Reviewed

    Naoko Iwata, Shintaro Iwama, Yoshihisa Sugimura, Yoshinori Yasuda, Kohtaro Nakashima, Seiji Takeuchi, Daisuke Hagiwara, Yoshihiro Ito, Hidetaka Suga, Motomitsu Goto, Ryoichi Banno, Patrizio Caturegli, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Arima

    PITUITARY   Vol. 20 ( 3 ) page: 301 - 310   2017.6

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    Purpose IgG4-related disease is a systemic inflammatory disease characterized by infiltration of IgG4-positive plasma cells into multiple organs, including the pituitary gland. Autoimmunity is thought to be involved in the pathogenesis of IgG4-related disease. The diagnosis of IgG4-related hypophysitis (IgG4-RH) is difficult because its clinical features, such as pituitary swelling and hypopituitarism, are similar to those of other pituitary diseases, including lymphocytic hypophysitis and sellar/suprasellar tumors. The presence and significance of anti-pituitary antibodies (APA) in IgG4-RH is unclear.
    Methods In this case-control study, we used single indirect immunofluorescence on human pituitary substrates to assess the prevalence of serum APA in 17 patients with IgG4-RH, 8 control patients with other pituitary diseases (lymphocytic infundibulo-neurohypophysitis, 3; craniopharyngioma, 2; germinoma, 3), and 9 healthy subjects.We further analyzed the endocrine cells targeted by the antibodies using double indirect immunofluorescence.
    Results APA were found in 5 of 17 patients with IgG4-RH (29%), and in none of the pituitary controls or healthy subjects. The endocrine cells targeted by the antibodies in the 5 IgG4-RH cases were exclusively corticotrophs. Antibodies were of the IgG1 subclass, rather than IgG4, in all 5 cases, suggesting that IgG4 is not directly involved in the pathogenesis. Finally, antibodies recognized pro-opiomelanocortin in 2 of the cases.
    Conclusions Our study suggests that autoimmunity is involved in the pathogenesis of IgG4-RH and that corticotrophs are the main antigenic target, highlighting a possible new diagnostic marker for this condition.

    DOI: 10.1007/s11102-016-0780-8

    Web of Science

  43. Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice. Reviewed International journal

    Aiko Inoue, Xian Wu Cheng, Zhe Huang, Lina Hu, Ryosuke Kikuchi, Haiying Jiang, Limei Piao, Takeshi Sasaki, Kohji Itakura, Hongxian Wu, Guangxian Zhao, Yanna Lei, Guang Yang, Enbo Zhu, Xiang Li, Kohji Sato, Teruhiko Koike, Masafumi Kuzuya

    Journal of cachexia, sarcopenia and muscle   Vol. 8 ( 3 ) page: 370 - 385   2017.6

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    BACKGROUND: Exercise train (ET) stimulates muscle response in pathological conditions, including aging. The molecular mechanisms by which exercise improves impaired adiponectin/adiponectin receptor 1 (AdipoR1)-related muscle actions associated with aging are poorly understood. Here we observed that in a senescence-accelerated mouse prone 10 (SAMP10) model, long-term ET modulated muscle-regenerative actions. METHODS: 25-week-old male SAMP10 mice were randomly assigned to the control and the ET (45 min/time, 3/week) groups for 4 months. Mice that were maintained in a sedentary condition served controls. RESULTS: ET ameliorated aging-related muscle changes in microstructure, mitochondria, and performance. The amounts of proteins or mRNAs for p-AMPKα, p-Akt, p-ERK1/2, p-mTOR, Bcl-XL, p-FoxO3, peroxisome proliferators-activated receptor-γ coactivator, adiponectin receptor1 (adpoR1), and cytochrome c oxidase-IV, and the numbers of CD34+ /integrin-α7+ muscle stem cells (MuSCs) and proliferating cells in the muscles and bone-marrow were enhanced by ET, whereas the levels of p-GSK-3α and gp91phox proteins and apoptotic cells were reduced by ET. The ET also resulted in increased levels of plasma adiponectin and the numbers of bone-marrow (BM)-derived circulating CD34+ /integrin-α7+ MuSCs and their functions. Integrin-α7+ MuSCs of exercised mice had improved changes of those beneficial molecules. These ET-mediated aged muscle benefits were diminished by adiponectin and AdipoR1 blocking as well as AMPK inhibition. Finally, recombinant mouse adiponectin enhanced AMPK and mTOR phosphorylations in BM-derived integrin-α7+ cells. CONCLUSIONS: These findings suggest that ET can improve aging-related impairments of BM-derived MuSC regenerative capacity and muscle metabolic alterations via an AMPK-dependent mechanism that is mediated by an adiponectin/AdipoR1 axis in SAMP10 mice.

    DOI: 10.1002/jcsm.12166

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    PubMed

  44. Adiponectin Is Inversely Associated With Estimated Intramuscular Fat Index In Middle-aged And Elderly Adults

    Maya Hioki, Nana Kanehira, Teruhiko Koike, Akira Saito, Kiyoshi Shimaoka, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   Vol. 49 ( 5 ) page: 238 - 238   2017.5

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    Language:Japanese   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1249/01.mss.0000517502.68144.4a

    Web of Science

  45. Relationships of Muscle Quality among Back, Lower and Upper Limbs in Older Individuals Invited Reviewed

    Akito Yoshiko, Takashi Kaji, Hiroki Sugiyama, Teruhiko Koike, Yoshiharu Oshida, Hiroshi Akima

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   Vol. 49 ( 5 ) page: 239 - 239   2017.5

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    Language:Japanese   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1249/01.mss.0000517506.91015.fc

    Web of Science

  46. Three-dimensional comparison of intramuscular fat content between young and old adults Reviewed

    Akito Yoshiko, Maya Hioki, Nana Kanehira, Kiyoshi Shimaoka, Teruhiko Koike, Hisataka Sakakibara, Yoshiharu Oshida, Hiroshi Akima

    BMC MEDICAL IMAGING   Vol. 17   2017.2

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    Background: Fat infiltration within skeletal muscle is known as intramuscular fat (IMF), which increases with aging. Studies have assessed IMF content, using the mid-thigh as a representative location. However, three-dimensional IMF distribution is not well understood. The aim of this study was to compare the IMF content in young and old adults by assessing its distribution along the length of the thigh.
    Methods: Consecutive transaxial images of the right thighs in 15 young (age, 21.0 +/- 0.4) and 15 old (age, 70.7 +/- 3.8) were obtained by magnetic resonance imaging. We measured IMF cross-sectional area (CSA), skeletal muscle CSA and calculated volume-and CSA-based IMF content for the quadriceps femoris (QF), hamstring (HM) and adductor (AD). CSA-based calculations were performed at every 10% of femur length (Lf), with 0% Lf and 100% Lf indicating the proximal and distal ends of femur.
    Results: IMF CSAs along the length of the thigh were similar in both age groups. In contrast, skeletal muscle CSAs in all three muscle groups were significantly lower in old adults than in young adults (variation: -15.2 to -1.6 cm(2), P &lt; 0.05). Thus, in volume-based measurements, the older adults had higher IMF contents than the younger adults (9.5% to 14.3% vs. 4.8% to 8.6%, respectively; P &lt; 0.05). However, such age-dependent differences were not observed at the mid-thigh in the QF and AD.
    Conclusion: The results demonstrated an age-related increase in IMF content-confirmed in areas of the thigh-primarily based on finding lower amounts of skeletal muscle mass in CSAs in the older adults.

    DOI: 10.1186/s12880-017-0185-9

    Web of Science

  47. Cathepsin K-mediated Notch 1 activation contributes to neovascularisation in response to hypoxia. Reviewed

    41) H. Jiang, XW. Cheng, GP. Shi, L. Hu, A Inoue, Y. Yamamura, H. Wu, K. Takeshita, X. Li, Z. Huang, H. Song, M. Asai, C. Hao, K. Unno, T. Koike, Y. Oshida, K. Okumura, T. Murohara, M. Kuzuya.

    Nat Commun   Vol. 5   page: 3838.   2014.6

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    DOI: doi: 10.1038/ncomms4838

  48. b-Hydroxy-b-methylbutyrate suppresses tumor necrosis factor-a/interferon-g-induced MuRF expression in C2C12 cells. Reviewed

    K. Kimura, XW. Cheng, A. Inoue, L. Hu, T. Koike, M. Kuzuya

    Nutr Res   Vol. 34   page: 368-374   2014

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  49. Enhanced muscle pump during mild dynamic leg exercise inhibits sympathetic vasomotor outflow. Reviewed

    K. Katayama, K. Ishida, M. Saito, T. Koike, A. Hirasawa, M. Saito.

    Physiol Rep   Vol. 2   page: e12070   2014

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    DOI: DOI: 10.14814/phy2.12070

  50. Hypoxic effects on sympathetic vasomotor outflow and blood pressure during exercise with inspiratory resistance. Reviewed

    K. Katayama, S. Yamashita, K. Ishida, E. Iwamoto,T. Koike, M. Saito.

    Am J Physiol Regul Integr Comp Physiol   Vol. 304 ( 5 ) page: R374-R382   2013.3

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    DOI: 10.1152/ajpregu.00489.2012.

  51. Effects of angiotensin II AT1 receptor inhibition and exercise training on insulin action in rats on high-fat diet. Reviewed

    Z. Wang , T. Koike, P. Li, H. Jiang , Y. Natsume , L. Mu , T. Chen , Y. Oshida.

    Life Sciences   Vol. 90   page: 322-327   2012

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  52. Acute treatment with candesartan cilexetil, an angiotensin II type 1 receptor blocker, improves insulin sensitivity in high-fructose diet-fed rats. Reviewed

    P. Li, T. Koike, H.Jiang, Z. Wang, Y. Kawata, Y. Oshida.

    Horm Metab Res   Vol. 44 ( 4 ) page: 286-290   2012

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  53. 高果糖食負荷ラットでのインスリン作用に対するアロプリノールの影響

    姜海英、小池晃彦、木蘭、夏目有紀枝、王忠華、成憲武、押田芳治

    総合保健体育科学   Vol. 35 ( 1 ) page: 23-27   2012

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  54. 健康教室に参加する一般高齢者のヘルスリテラシーと運動能力および動脈硬化指標

    大西丈二、飯田蓉子、小池晃彦、荒深裕規、梶岡多恵子、島岡清、柳本有二、榊原久孝

    総合保健体育科学   Vol. 35 ( 1 ) page: 29-33   2012

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  55. BMI30kg/m2以上の若年肥満男性の食事および身体活動の特徴

    夏目有紀枝、小池晃彦、押田芳治

    総合保健体育科学   Vol. 35 ( 1 ) page: 35-40   2012

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  56. Inspiratory muscle fatigue increases sympathetic vasomotor outflow and blood pressure during submaximal exercise. Reviewed

    Keisho Katayama, Erika Iwamoto, Koji Ishida1, Teruhiko Koike, and Mitsuru Saito.

    Am J Physiol Regul Integr Comp Physiol   Vol. 302   page: R1167-R1175   2012

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  57. Association between gait speed and bone strength in community-dwelling postmenopausal Japanese women. Reviewed

    Takahiro Sakazaki, Teruhiko Koike, Yuji Yanagimoto, Yoshiharu Oshida.

    Environ Health Prev Med     2012

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    DOI: DOI 10.1007/s12199-012-0267-9

  58. 国際生活機能分類(ICF)を用いた血液透析患者に対するアセスメントツールの開発

    筒井秀代、多和田英夫、加藤ふみ、伊藤晃、山崎親雄、小池晃彦、押田芳治

    腎臓   Vol. 34 ( 2 ) page: 129-133   2011

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  59. The effect of intense interval cycle-training on umloading-induced dysfunction and atrophy in the human calf muscle. Reviewed

    Norio hotta, Koji Ishida, Kohei Sato, Teruhiko Koike, Keisho Katayama, Hiroshi Akima.

    J Physiol Anthropol   Vol. 30 ( 1 ) page: 29-35   2011

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  60. 地域在住閉経後女性の骨強度と最速歩行時の速度・歩幅との関連-膝伸展力の影響-

    坂崎貴彦、小池晃彦、柳本有二、森和、押田芳治

    総合保健体育科学   Vol. 34 ( 1 ) page: 15-18   2011

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  61. 特定健診受診者における運動習慣と健康関連QOLとの関連性-トランスセオリティカルモデルを用いた運動定着群と未定着群での比較

    松本大輔、瓜谷大輔、浅野恭代、小池晃彦、押田芳治

    総合保健体育科学   Vol. 34 ( 1 ) page: 5-9   2011

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  62. 高果糖食ラットでのスーパーハイブリッドガス充填水によるインスリン抵抗性改善効果

    姜海英、小池晃彦、王忠華、木蘭、陳塔娜、夏目有紀枝、押田芳治

    総合保健体育科学   Vol. 34 ( 1 ) page: 1-4   2011

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  63. サルコペニアの今:サルコペニアの対策、予防と治療

    小池晃彦、秋間広、柳本有二、片山敬章、石田浩司、坂崎貴彦、夏目有紀枝、押田芳治

    運動・物理療法   Vol. 22 ( 3 ) page: 307-314   2011

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  64. Hypoxia augments muscle sympathetic neural response to leg cycling. Reviewed

    Am J Physiol Regul Integr Comp Physiol   Vol. 301   page: R456-R464   2011

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  65. Alanine aminotransferase and γ-glutamyltransferase as markers for elevated insulin resistance–associated metabolic abnormalities in obese Japanese men younger than 30 years of age Reviewed

    Teruhiko Koike, Maiko Miyamotob, Yoshiharu Oshida

    Obesity Research & Clinical Practice   Vol. 4   page: e73-e79   2010

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  66. 医学部生における各種ウイルス抗体価の検討

    山本明子、近藤孝晴、押田芳治、石黒洋、小池晃彦、小川豊明、津田均、古橋忠晃

    総合保健体育科学   Vol. 33 ( 1 ) page: 65-70   2010

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  67. 名古屋大学における「健康・スポーツ科学実習」授業に関する学生の意識調査-実習を選択しない学生の観点から-

    石田浩司、西田保、蛭田秀一、片山敬章、山本裕二、石黒洋、小池晃彦、小林洋平

    総合保健体育科学   Vol. 33 ( 1 ) page: 49-63   2010

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  68. J-SACLテストにより評価した2型糖尿病患者のストレスにおける男女差について

    筒井秀世、小池晃彦、石黒哲也、押田芳治

    総合保健体育科学   Vol. 33 ( 1 ) page: 17-21   2010

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  69.  特定健診参加者が求める運動環境

    松本大輔、瓜谷大輔、浅野恭代、小池晃彦、押田芳治

    総合保健体育科学   Vol. 33 ( 1 ) page: 1-5   2010

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  70. Combined effect of short-term calorie restriction and exercise on insulin action in normal rats. Reviewed

    Haiying Jiang, Teruhiko Koike, Ping Li, Zhonghua Wang, Yuki Kawata, Yoshiharu Oshida.

    Horm Metab Res   Vol. in press   2010

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  71. *Waist circumference is positively associated with insulin resistance but not with fasting blood glucose among moderately to highly obese young Japanese men. Reviewed

    T. Koike, M. Miyamoto, Y. Oshida.

    Obesity Research & Clinical Practice   Vol. 3 ( 109-114 )   2009

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  72. 医療従事者養成教育にティーチング・アシスタント(TA)の月給制普及を(報告)

    坂崎貴彦、小池晃彦、押田芳治

    総合保健体育科学   Vol. 32   page: 21-23   2009

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  73.  大学ラグビー選手の身体組成・運動機能とハムストリングの肉離れとの関連

    松本大輔、中本順、成瀬文博、山田実、小池晃彦、押田芳治

    総合保健体育科学   Vol. 321   page: 25-29   2009

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  74. The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans. Reviewed

    K. Sakuma, W Kohei, N Norio, T Koike, K Ishida, K Katayama, H Akima.

    Acta Physiologica   Vol. 197   page: 151-159   2009

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  75. Cycle ergometer exercise to counteract muscle atrophy during unilateral lower limb suspension. Reviewed

    H. Akima, N Hotta, K Sato, K Ishida, T.Koike.

    Aviat Space Environ Med   Vol. 80 ( 7 ) page: 652-656   2009

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  76. Identification of hemodialysis patients' common problems using the International Classification of Functioning, Disability and Health. Reviewed

    H. Tsutsui, T. Koike, C. Yamazaki, A. Ito, F. Kato, H. Sato, H. Tawada, Y. Oshida.

    Therapeutic Apheresis and Dialysis   Vol. 13 ( 3 ) page: 186-192   2009

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  77. 中等度以上肥満男子学生でのウエスト周囲径と血糖コントロールとの関連

    小池晃彦、押田芳治

    CAMPUS HEALTH   Vol. 46 ( 1 ) page: 164   2009

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  78. Effects of Continuous Low-carbohydrate Diet after Long-term Exercise on GLUT-4 Protein Content in Rat Skeletal Muscle. Reviewed

    M.Kubota, K.Koshinaka, Y. Kawata, T. Koike, Y. Oshida.

    Horm Metab Res   Vol. 40 ( 24 )   2008

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  79. *Raised homocysteine and low folate and vitamin B-12 concentrations predict cognitive decline in community-dwelling older Japanese adults. Reviewed

    T. Koike, M. Kuzuya, K. Kanda, K. Okada, S. Izawa, H. Enoki, A. Iguchi.

    Clin Nutr.   Vol. 27 ( 6 ) page: 865-871   2008

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  80. A High-fructose diet impairs Akt and PKCζ, Phosphorylation and Glut4 translocation in rat skeletal muscle. Reviewed

    P. Li, T. Koike, B. Qin, M. Kubota, Y. Kawata, Y. J. Jia, Y. Oshida.

    Horm Metab Res   Vol. 40 ( 8 ) page: 528-532   2008

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  81. 肥満若年男性におけるウエスト周囲径とインスリン抵抗性との関連‐臍レベルウエスト周囲径と最小ウエスト周囲径の比較

    小池晃彦、押田芳治

    総合保健体育科学   Vol. 31 ( 1 ) page: 39-42   2008

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  82. メタボリックシンドロームに対する運動・スポーツの有効性-耐糖能異常

    押田芳治、川田裕樹、小池晃彦

    体育の科学   Vol. 58 ( 7 ) page: 461-467   2008

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  83. ICFに用づいた血液透析患者に対するアセスメントツールの開発

    筒井秀代、加藤ふみ、佐藤久光、伊藤晃、山崎親雄、多和田英夫、小池晃彦、押田芳治

    透析会誌   Vol. 41 ( 4 ) page: 263   2008

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  84. 肥満にともなうインスリン抵抗性に対するSNPの効果 Reviewed

    賈燕君、久保田正和、小池晃彦、川田裕樹、筒井秀代、李平

    総合保健体育科学   Vol. 30 ( 1 ) page: 57-60   2007

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  85. The nutritional status of frail elderly with care needs according to the mini-nutritional assessment. Reviewed

    S. Izawa, M. Kuzuya, K. Okada, H. Enoki, T. Koike, S. Kanda, and A. Iguchi

    Clin Nutr   Vol. 25   page: 962-967   2006

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  86. The effect of total homocysteine elevation and related B vitamins deficiency on cognitive function and depression in elderly population Reviewed

    Teruhiko Koike, Masafumi Kuzuya, Shigeru Kanda, Kiwako Okada, Sachiko Izawa, Hiromi Enoki, Akihisa Iguchi

    Vitamins(Japan)   Vol. 79 ( 12 ) page: 583-591   2005.12

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  87. Lack of correlation between total lymphocyte count and nutritional status in the elderly. Reviewed

    M. Kuzuya, S. Kanda, T. Koike, Y. Suzuki, and A. Iguchi.

    Clin Nutr   Vol. 24   page: 427-432   2005

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    There were no significance correlation between total lymphocyte count and anthropometry measurements, serum albumin, total cholesterol levels, or MNA score, suggesting that TLC is not a suitable marker of malnutrition in the elderly.

  88. Evaluation of Mini-Nutritional Assessment for Japanese frail elderly. Reviewed

    M. Kuzuya, S. Kanda, T. Koike, Y. Suzuki, S. Satake, and A. Iguchi

    Nutrition   Vol. 21   page: 498-503   2005

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    The full and short forms of the MNA were useful tools to identify elderly Japanese patients with malnutrition or risk of malnutrition. However, the full MNA cutoff point for malnutrition should be modulated for this population.

  89. 加齢が骨格筋のインスリン作用に及ぼす影響

    久保田和、越中敬一、秦柏林、大澤功、小池晃彦、押田芳治

    総合保健体育科学   Vol. 28   page: 9-13   2005

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  90. Elongation and secretion of tissue inhibitor of metalloproteinases 1 by human microvascular endothelium cells cultured in collagen gels is stimulated by mitomycin C. Reviewed

    MA Hamner, RB Vernon, MD Gooden, T. Koike, MJ Reed

    Endothelium   Vol. 12   page: 97-101   2005

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  91. Increased Expression of Elastolysis Cysteine Proteases, Cathepsins S and K, in the neointima of balloon-injured rat carotid arteries. Reviewed

    XW. Cheng, M. Kuzuya, T. Sasaki, A. Koji, S. Kanda, D. Sumi, T. Koike, K, Maeda, N, Tamaya-Mori, G-P. Shi, N. Saito, and A. Iguchi.

    Am. J. Pathol.   Vol. 164   page: 243-251   2004

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  92. A novel model of occlusive thrombus formation in mice. Reviewed

    T. Sasaki, M. Kuzuya, XW. Cheng, K, Nakamura, N. Tamaya-Mori, K. Maeda, S. Kanda, T. Koike, K. Sato, and A. Iguchi.

    Lab. Invest.   Vol. 84   page: 1526-1532   2004

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  93. Green tea catechins inhibit neointimal hyperplasia in a rat carotid arterial injury model by TIMP-2 overexpression. Reviewed

    XW. Cheng, M. Kuzuya, T. Sasaki, S. Kanda, N. Tamaya-Mori, T. Koike, K, Maeda, N, E. Nishitani, and A. Iguchi.

    Cardiovas Res.   Vol. 62   page: 594-602   2004

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  94. Sarcopeniaの対策

    小池晃彦、葛谷雅文、井口昭久

      Vol. 42   page: 919-923   2004

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  95. Inhibition of TIMP1 enhances angiogenesis in vivo and cell migration in vitro. Reviewed

    M.J.Reed, T.Koike, E. Sadoun, E.H.Sage, P.Puolakkainen.

    Mircovasc. Res.   Vol. 65   page: 9-17   2003

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  96. Atorvastatin, HMG-CoA reductase inhibitor, reduces bone resorption in the elderly. Reviewed

    M. Kuzuya, Y. Suzuki, T. Asai, T. Koike, S. Kanda, A. Nakamura, S. Satake, H. Umegaki, A. Iguchi..

    Journal of American Geriatric Society   Vol. 51   page: 1677-1678   2003

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  97. *Inhibited Angiogenesis in Aging: A Role for TIMP-2. Reviewed

    T.Koike, RB.Vernon, MD Gooden, E Sadoun, MJ. Reed.

    J. Gerontol A Biol Sci Med Sci.   Vol. 58   page: B798-805   2003

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  98. * MT1-MMP, but not secreted MMPs, influences the migration of human microvascular endothelial cells in 3-dimensional collagen gels. Reviewed

    T. Koike, R.B.Vernon, M.A.Hamner, E. Sadoun, M.J. Reed.

    J. Cell Biochem.   Vol. 86 ( 748-758 )   2002

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  99. 高齢者に対するCarvedilolの心血行動態に及ぼす作用と忍容性の検討 Reviewed

    浅井俊亘、葛谷雅文、小池晃彦、神田茂、前田恵子、井口昭久

    日老医誌   Vol. 39   page: 187-192   2002

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  100. Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways. Reviewed

    S. Ai, M. Kuzuya, T. Koike, T. Asai, S. Kanda, K. Maeda, T. Shibata, and A. Iguchi.

    Atherosclerosis   Vol. 155   page: 321-327   2001

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  101. VEGF Protects against oxidized LDL toxicity to endothelial cells by an intracellular glutathione-dependent mechanism through the KDR receptor. Reviewed

    M. Kuzuya, MA.Ramos, S. Kanda, T. Koike, T. Asai, K. Maeda, K. Shitara, and M. Shibuya, and A. Iguchi.

    Arterioscler Thromb Vasc Biol.   Vol. 21   page: 765-770   2001

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  102. Matrix Metalloproteinase and &#61537;v&#61538;3 integrin-dependent vascular smooth muscle cell invasion through the type I collagen lattice. Reviewed

    S. Kanda, M. Kuzuya, M.A.Ramos, T. Koike, Y. Yoshino, S. Ikeda, and A. Iguchi.

    Arteriosclerosis, Thrombosis, and Vascular Biology   Vol. 20   page: 998-1005   2000

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  103. Activation of MMP-2 by Clostridium difficile toxin B in bovine smooth muscle cells. Reviewed

    T. Koike, M. Kuzuya, T. Asai, S. Kanda, X. W. Cheng, Y. Banno, K. Watanabe, Y. Nozawa, and A. Iguchi.

    Biochem. Biophys.Res.Commun.   Vol. 277   page: 43-46   2000

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  104. Induction of apoptotic cell death in vascular endothelial cell cultured in 3-dimentional collagen lattice. Reviewed

    M. Kuzuya, S. Satake, M. A. Ramos, S. Kanda, T. Koike, K. Yoshino, S. Ikeda, and A. Iguchi.

    Experimental Cell Research   Vol. 248   page: 498-508   1999

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  105. Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1. Reviewed

    A. A. Thant, T. T. Sein, E. Liu, M. Kazuya, F. Kikkawa, T. Koike, S. Motoharu, S. Matsuda, and M. Hamaguchi.

    Oncogene   Vol. 18   page: 6555-6563   1999

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  106. 多剤投与に対する注意と工夫

    小池晃彦、井口昭久

    臨床と研究   Vol. 75 ( 2 )   1998

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  107. Mercuric chloride mediates a protein sulfhydryl modification-based pathway of signal transduction for activating Src kinase which is independent of the phosphorylation /dephosphorylation of a carboxy terminal tyrosine. Reviewed

    M. Pu, A. Akhand, M. Kato, T. Koike, M. Hamaguchi, H. Suzuki, and I. Nakashima.

    J. Cell. Biochem.   Vol. 63   page: 104-114   1996

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  108. Tyrosine phosphorylation is crucial for growth signaling by tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2). Reviewed

    K. Yamashita, M. Suzuki, H. Iwata, T. Koike, M. Hamaguchi, A. Shinagawa, T. Noguchi, and T. Hayakawa.

    FEBS. Lett.   Vol. 396   page: 103-107   1996

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  109. Evidence of a novel redox-linked activation mechanism for the Src kinase which is independent of tyrosine 527-mediated regulation. Reviewed

    M. Pu, A. Akhand, M. Kato, M. Hamaguchi, T. Koike, H. Iwata, H. Sabe, H. Suzuki, and I. Nakashima.

    Oncogene   Vol. 13   page: 2615-2622   1996

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  110. The structure and function of cadherins and their pathophysiological roles in diseases

      Vol. 53 ( 7 ) page: 1578-1584   1995

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  111. *Stem cell factor-induced signal transduction in rat mast cells. Reviewed

    T. Koike, K. Hirai, Y. Morita, and Y. Nozawa.

    J. Immunol.   Vol. 151   page: 359-366   1993

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  112. SCF/c-kit receptor mediated arachidonic acid liberation in rat mast cells. Reviewed

    T. Koike, Mizutani, K. Hirai, Y. Morita, and Y. Nozawa.

    Biochem. Biophys. Res. Comm.   Vol. 197   page: 1570-1577   1993

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  113. 血小板活性化の情報伝達

    永田浩一、小池晃彦、鈴木武志、野澤義則

    実験医学(増刊 情報伝達研究の新しい展開)   Vol. 11   page: 191-196   1993

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  114. ホスホリパーゼDの活性化機構

    金保安則、加納宏行、小池晃彦、岡野幸雄、野澤義則

    実験医学(増刊 情報伝達研究の新しい展開)   Vol. 11   page: 31-37   1993

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  115. 血小板系 3. イノシトールリン脂質代謝と細胞応答 病態にも関連して Invited

    岡野幸雄、小池晃彦、永田浩一、野澤義則

    臨床病理   Vol. 91   page: 194-204   1991

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  116. Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses. Reviewed

    S. Nakashima, T. Koike, and Y. Nozawa

    Mol. Pharmacol.   Vol. 39   page: 475-480   1991

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  117. 血小板シグナル伝導系

    小池晃彦、中島茂、野澤義則

    治療   Vol. 73   page: 913-920   1991

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Books 13

  1. 科学的根拠に基づく糖尿病診療ガイドライン2016 (日本糖尿病学会編)

    押田芳治、小池晃彦 、岩間信太郎( Role: Sole author ,  運動療法)

    南江堂  2016 

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    Language:Japanese

  2. 運動処方(運動療法):糖尿病専門医研修ガイドブック(改訂第6版)(日本糖尿病学会編)

    小池晃彦( Role: Sole author)

    診断と治療社  2014 

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    Language:Japanese

  3. 運動療法: 科学的根拠に基づく糖尿病診療ガイドライン(日本糖尿病学会編)

    押田芳治、小池晃彦( Role: Joint author)

    南江堂  2013 

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    Language:Japanese

  4. 高齢者の検査基準値ガイド(リン、アニオンギャップ、マグネシウム、亜鉛)

    小池晃彦 (下方浩史編)( Role: Joint author)

    中央法規  2011.10 

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    Language:Japanese

  5. Identification of hemodialysis patients' physical and psychosocial problems using the international classification of functioning, disability and health (ICF). (Hemodialysis-Different Aspects)

    ( Role: Joint author)

    2011 

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    Language:English

  6. 糖尿病ナビゲーター(門脇孝編) 糖尿病運動療法のエビデンス

    小池晃彦、押田芳治( Role: Joint author)

    メディカルレビュー社  2010.9 

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  7. 運動療法 科学的根拠に基づく糖尿病診療ガイドブック2010

    押田芳治、小池晃彦( Role: Joint author)

    南江堂  2010 

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    Language:Japanese

  8. Wound Healing:Methods and ProtocolsWound healing in aging

    MJ Reed, T. Koike, P. Puolakkainen P.( Role: Joint author)

    Humana Press  2003 

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    Language:English

  9. これからの老年医学

    井口昭久編( Role: Joint author)

    名古屋大学出版会  2000 

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    細胞老化(I-1-5;17-22),尿失禁(III-13-1;219-222),失神(III-13-3;225-227)

  10. 糖尿病専門医研修ガイドブック(改訂第8版)(日本糖尿病学会編)

    小池晃彦( Role: Contributor ,  運動処方(運動療法))

    診断と治療社  2020.12 

  11. 糖尿病専門医研修ガイドブック(改訂第8版)(日本糖尿病学会編)

    小池晃彦( Role: Contributor ,  運動処方(運動療法))

    診断と治療社  2020.12 

  12. 糖尿病専門医研修ガイドブック(改訂第7版)(日本糖尿病学会編)

    小池晃彦( Role: Contributor ,  運動処方(運動療法))

    診断と治療社  2017.5 

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  13. 糖尿病専門医研修ガイドブック(改訂第7版)(日本糖尿病学会編)

    小池晃彦( Role: Contributor ,  運動処方(運動療法))

    診断と治療社  2017.5 

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MISC 2

  1. Effect of acupuncture at acupoint of Shenshu (BL 23) on the bones of ovariectomized rats Reviewed

    Takeda Atsushi, Koike Teruhiko, Urata Shigeru, Ishida Torao, Oshida Yoshiharu

    JOURNAL OF TRADITIONAL CHINESE MEDICINE   Vol. 38 ( 1 ) page: 54-60   2018.2

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  2. Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice Reviewed

    Aiko Inoue, Xian Wu Cheng, Zhe Huang, Lina Hu, Ryosuke Kikuchi, Haiying Jiang, Limei Piao, Takeshi Sasaki, Kohji Itakura, Hongxian Wu, Guangxian Zhao, Yanna Lei, Guang Yang, Enbo Zhu, Xiang Li, Kohji Sato, Teruhiko Koike, Masafumi Kuzuya

    JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE   Vol. 8 ( 3 ) page: 370 - 385   2017.6

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    Background Exercise train (ET) stimulates muscle response in pathological conditions, including aging. The molecular mechanisms by which exercise improves impaired adiponectin/adiponectin receptor 1 (AdipoR1)-related muscle actions associated with aging are poorly understood. Here we observed that in a senescence-accelerated mouse prone 10 (SAMP10) model, long-term ET modulated muscle-regenerative actions.
    Methods 25-week-old male SAMP10 mice were randomly assigned to the control and the ET (45 min/time, 3/week) groups for 4 months. Mice that were maintained in a sedentary condition served controls.
    Results ET ameliorated aging-related muscle changes in microstructure, mitochondria, and performance. The amounts of proteins or mRNAs for p-AMPK alpha, p-Akt, p-ERK1/2, p-mTOR, Bcl-XL, p-FoxO3, peroxisome proliferators-activated receptor-gamma coactivator, adiponectin receptor1 (adpoR1), and cytochrome c oxidase-IV, and the numbers of CD34(+)/integrin-alpha(+)(7) muscle stem cells (MuSCs) and proliferating cells in the muscles and bone-marrow were enhanced by ET, whereas the levels of p-GSK-3 alpha and gp91phox proteins and apoptotic cells were reduced by ET. The ET also resulted in increased levels of plasma adiponectin and the numbers of bone-marrow (BM)-derived circulating CD34(+)/integrin-alpha(+)(7) MuSCs and their functions. Integrin-alpha(+)(7) MuSCs of exercised mice had improved changes of those beneficial molecules. These ET-mediated aged muscle benefits were diminished by adiponectin and AdipoR1 blocking as well as AMPK inhibition. Finally, recombinant mouse adiponectin enhanced AMPK and mTOR phosphorylations in BM-derived integrin-alpha(+)(7) cells.
    Conclusions These findings suggest that ET can improve aging-related impairments of BM-derived MuSC regenerative capacity and muscle metabolic alterations via an AMPK-dependent mechanism that is mediated by an adiponectin/AdipoR1 axis in SAMP10 mice.

    DOI: 10.1002/jcsm.12166

    Web of Science

Presentations 111

  1. 生涯健康支援~人生100年時代に向けた生活習慣 Invited

    小池晃彦

    第59回全国保健管理協会東海北陸地方部会研究集会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:岐阜(Web開催)  

  2. 生涯健康支援~人生100年時代に向けた生活習慣 Invited

    小池晃彦

    第59回全国保健管理協会東海北陸地方部会研究集会  2021.7 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:岐阜(Web開催)  

  3. 健康寿命の延伸を目指した運動とは? Invited

    小池晃彦

    第63回日本老年医学会学術集会  2021.6  日本老年医学会学

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋(web開催)  

  4. 健康寿命の延伸を目指した運動とは? Invited

    小池晃彦

    第63回日本老年医学会学術集会  2021.6  日本老年医学会学

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋(web開催)  

  5. D-アルロースは、自発的な運動はC57BL/6Jマウスの運動能力を改善する

    劉氷陽, 苟楊, 都築孝允, 王思嫻, 坂野僚一, 豊田行康, 小池晃彦

    第75回日本体力医学会大会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重(Web開催)   Country:Japan  

  6. 高ショ糖食摂取マウスの耐糖能改善における運動トレーニングとプシコース摂取の併用効果

    都築孝允, 上島将史, 牧原謙成, 小池晃彦, 豊田行康, 根岸隆之, 湯川和典

    第75回日本体力医学会大会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重(Web開催)   Country:Japan  

  7. D-アルロースは、高脂肪食を与えられたウイスターラットの骨格筋インスリン抵抗性を改善する

    苟楊, 劉氷陽, 程夢瑶, 王思嫻, 坂野僚一, 小池晃彦

    第75回日本体力医学会大会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重(Web開催)   Country:Japan  

  8. D-アルロースは、自発的な運動はC57BL/6Jマウスの運動能力を改善する

    劉氷陽、苟楊、都築孝允、王思嫻、坂野僚一、豊田行康、小池晃彦

    第75回日本体力医学会大会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重(Web開催)   Country:Japan  

  9. 高ショ糖食摂取マウスの耐糖能改善における運動トレーニングとプシコース摂取の併用効果

    都築孝允、上島将史、牧原謙成、小池晃彦、豊田行康、根岸隆之、湯川和典

    第75回日本体力医学会大会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重(Web開催)   Country:Japan  

  10. D-アルロースは、高脂肪食を与えられたウイスターラットの骨格筋インスリン抵抗性を改善する

    苟楊、劉氷陽、程夢瑶、王思嫻、坂野僚一、小池晃彦

    第75回日本体力医学会大会  2021.9 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重(Web開催)   Country:Japan  

  11. 運動トレーニングとプシコースの摂取がマウスの骨格筋におけるAMPK及びMAPK シグナルに与える影響

    中井夏水、都築孝允、玉城亜寿香、山田貴子、飯田哲郎、小池晃彦、豊田行康、 根岸隆之、湯川和典

    第74回日本体力医学会大会  2020.9 

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    Event date: 2020.9

  12. 運動トレーニングとプシコースの摂取がマウスの骨格筋におけるAMPK及びMAPK シグナルに与える影響

    中井夏水, 都築孝允, 玉城亜寿香, 山田貴子, 飯田哲郎, 小池晃彦, 豊田行康, 根岸隆之, 湯川和典

    第74回日本体力医学会大会  2020.9 

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    Event date: 2020.9

  13. 大腿四頭筋の筋酸素化動態および筋活動に対する低酸素の影響

    吉子彰人,片山敬章,石田浩司,安藤良介,小池晃彦.押田芳治,秋間 広

    日本運動免疫学研究会スプリングセミナー2020  2020 

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    Event date: 2020

  14. 大腿四頭筋の筋酸素化動態および筋活動に対する低酸素の影響

    吉子彰人, 片山敬章, 石田浩司, 安藤良介, 小池晃彦, 押田芳治, 秋間 広

    日本運動免疫学研究会スプリングセミナー2020  2020 

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    Event date: 2020

  15. 歩行速度による骨状態のスクリーニング

    坂崎貴彦、小池晃彦、柳本有二、尾﨑信暁、押田芳治

    第16回日本体力医学会 東海地方会学術集会 

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    Event date: 2012

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  16. 一次予防参加者のセルフエフィカシーおよびソーシャルサポートと精神的健康および幸福感等に与える効果について

    大西丈二、小池晃彦、榊原久孝、甲斐一郎

    第54回日本老年医学会 

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    Event date: 2012

    Language:Japanese  

    Country:Japan  

  17. “ICF Core Sets for Diabetes Mellitus”を用いた糖尿病患者の身体的・心理社会的問題点の抽出第4報

    筒井秀代、多和田英夫、楠正隆、石黒哲也、伊藤晃、尾﨑信暁、小池晃彦、押田芳治

    第54回日本糖尿病学会大会 

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    Event date: 2012

    Language:Japanese  

    Country:Japan  

  18. 糖尿病患者における新しい脂質管理目標、non-HDL-Cの検討

    後藤慎一、佐々木洋光、渡邊智香、松田淳一、渡邊有三、大沢功、小池晃彦、尾﨑信暁、押田芳治

    第54回日本糖尿病学会大会 

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    Event date: 2012

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  19. 高果糖食誘発インスリン抵抗性に対するeicosapentaenoic acid (EPA)の効果

    夏目有紀枝、小池晃彦、姜海英、王忠華、尾﨑信暁、押田芳治

    第54回日本糖尿病学会大会( 

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    Event date: 2012

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  20. 卵巣摘出ラットに対する腎兪穴への鍼は骨吸収を抑制する

    武田充史、浦田繁、石田寅夫、小池晃彦、尾崎信暁、押田芳治

    第85回日本内分泌学会 

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    Event date: 2012

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  21. インスリン抵抗性モデルラットにおけるeicosapentaenoic acid (EPA)の効果

    夏目有紀枝、小池晃彦、姜海英、王忠華、尾﨑信暁、押田芳治

    第85回日本内分泌学会 

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    Event date: 2012

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  22. “ICF Core Sets for Diabetes Mellitus”を用いた糖尿病患者の身体的・心理社会的問題点の抽出第3報

    筒井秀代、楠正隆、石黒哲也、伊藤晃、大西丈二、小池晃彦、押田芳治

    第54回日本糖尿病学会大会 

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    Event date: 2011

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  23. Muscle sympathetic activity during submaximal cycling exercise in hypoxia. International conference

    Katayama, K., Ishida, K., Iwamoto, E., Iemitsu, M., Koike, T., Saito M.

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    Event date: 2011

    Language:English  

    Country:Japan  

  24. 標準体重男性で“腹八分”と運動はインスリン抵抗性と慢性炎症を改善する

    小池晃彦、片山敬章、夏目有紀枝、岩本えりか、石田浩司、押田芳治

    第49回全国大学保健管理研究集会 

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    Event date: 2011

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  25. 治療形態による糖尿病患者の身体的・心理社会的問題の違い

    筒井秀代、楠正隆、多和田英夫、石黒哲也、伊藤晃、小池晃彦、押田芳治

    第84回 日本糖尿病学会中部地方会 

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    Event date: 2011

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  26. カロリー制限と運動がインスリン感受性に及ぼす影響

    姜海英、小池晃彦、王忠華、夏目有紀枝、木蘭、陳塔娜、押田芳治

    第84回 日本糖尿病学会中部地方会 

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    Event date: 2011

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  27. 認知症高齢者とその介護者に対する在宅におけるテレビ電話システム(Skype)を用いた支援の有効性

    保利美也子、古家彩名、榊原久孝、久保田正和、小池晃彦、木下彩栄

    第22回日本在宅医療学会 

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    Event date: 2011

    Language:Japanese  

    Country:Japan  

  28. 名古屋市介護予防一般高齢者施策事業参加者の自己効力感とソーシャルサポート

    大西丈二、會田信子、榊原久孝、甲斐一郎、小池晃彦

    第53回日本老年医学会 

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    Event date: 2011

    Language:Japanese  

    Country:Japan  

  29. デジタルカメラと歩数計を利用した高齢者の活動および食事摂取の評価法に関する検討

    飯田蓉子、大西丈二、小池晃彦

    第53回日本老年医学会 

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    Event date: 2011

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  30. Effects of candesartan combined with exercise on insulin action in high-fat diet fed rats.

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    Event date: 2011

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  31. アロプリノール投与がインスリン感受性に及ぼす影響

    姜海英、小池晃彦、王忠華、夏目有紀枝、木蘭、陳塔娜、押田芳治

    第54回日本糖尿病学会大会 

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    Event date: 2011

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  32. 若年肥満男性の食環境と栄養素摂取状況の関連について

    榎 裕美、葛谷雅文、押田芳治、小池晃彦

    第 17回日本未病システム学会 

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    Event date: 2010.11

    Language:Japanese  

    Country:Japan  

  33. 低酸素環境における動的運動時の呼吸循環応答

    片山敬章、石田浩司、岩本えりか、家光素行、小池晃彦、齊藤 満

    第65回日本体力医学会 

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    Event date: 2010

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  34. 糖尿病患者におけるGFRと尿中アルブミンの組み合わせの評価

    後藤慎一、佐々木洋光、渡邊有三、大沢功、小池晃彦、押田芳治

    第53回日本糖尿病学会大会 

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    Event date: 2010

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  35. “ICF Core Sets for Diabetes Mellitus”を用いた糖尿病患者の身体的・心理社会的問題点の抽出第2報

    筒井秀世、楠正隆、石黒哲也、小池晃彦、押田芳治

    第53回日本糖尿病学会大会 

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    Event date: 2010

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  36. インスリン感受性の及ぼすカロリー制限と運動の影響

    姜海英、小池晃彦、王忠華、筒井秀世、押田芳治

    第53回日本糖尿病学会大会 

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    Event date: 2010

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  37. 地域在住閉経後女性の体力指標としてのWBIおよび握力の役割

    坂崎貴彦、柳本有二、小池晃彦、押田芳治

    第14回日本体力医学会(東海地方会学術集会) 

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    Event date: 2010

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  38. 「高齢社会と体力医学(シンポジウム)」臨床的立場から、虚弱性をいかに防ぐか

    小池晃彦

    第14回日本体力医学会 東海地方会学術集会 

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    Event date: 2010

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  39. 地域在住閉経後女性の下肢筋力と身体能力および骨強度との関係

    坂崎貴彦、柳本有二、小池晃彦、押田芳治

    第80回日本衛生学会 

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    Event date: 2010

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  40. 医学部生における各種ウイルス抗体価の検討

    山本明子、近藤孝晴、押田芳治、石黒洋、小池晃彦、小川豊昭、津田均、古橋忠晃

    第43回全国大学保健管理研究集会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  41. 高齢女性の体重支持指数(WBI)からみた踵骨骨強度と体力測定値との関連

    坂崎貴彦,柳本有二, 秋山眞視, 小池晃彦,押田芳治

    第64回日本体力医学会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  42. 振動刺激の深達度がF波に及ぼす影響について

    戸田香,小池晃彦,坂崎貴彦,對馬明,澤浩成,押田芳治

    第64回日本体力医学会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  43. ARBの急性投与により、高果糖誘発インスリン抵抗性が改善する

    李萍、小池晃彦、川田裕樹、姜海英、王忠華、押田芳治

    第52回日本糖尿病学会大会 

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    Event date: 2009

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  44. 薬学教育の第三者評価検討の経緯からみた教員組織充実の方策

    坂崎貴彦,小池晃彦,押田芳治

    日本薬学会第129年会 

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    Event date: 2009

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  45. Effect of Intensive interval and resistant training on muscle size and function during unloading. International conference

    The 56th Annual Meeting of American College of Sports Medicine 

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    Event date: 2009

    Language:English   Presentation type:Oral presentation (general)  

  46. 糖尿病食事療法における食物繊維摂取量の有効性(第二報)

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    Event date: 2009

    Language:Japanese   Presentation type:Oral presentation (general)  

  47. 早期糖尿病腎症患者における血清シスタチンC(Cys-C)推算GFRの変化

    後藤慎一、佐々木洋光、渡邊有三、大沢功、小池晃彦、押田芳治

    第52回日本糖尿病学会大会 

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    Event date: 2009

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  48. 片足サスペンジョンがレッグプレス運動時の筋活動に与える影響

    渡邊航平、片山敬章、石田浩司、小池晃彦、秋間広

    第63回日本体力医学会大会 

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    Event date: 2008

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  49. 若年肥満男性におけるインスリン抵抗性に関連する異常発現に指標としてのALTおよびGTTの意義

    小池晃彦、押田芳治

    第51回日本糖尿病学会大会 

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    Event date: 2008

    Language:Japanese  

  50. シスタチンC(Cys-C)を用いた糖尿病患者の推定GFRの評価

    後藤慎一、佐々木洋光、渡辺有三、大沢功、小池晃彦、押田芳治

    第51回日本糖尿病学会大会 

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    Event date: 2008

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  51. 糖尿病と社会経済的地位(SES)に関する文献研究

    筒井秀代、田中剛、近藤克則、小池晃彦、押田芳治

    第51回日本糖尿病学会大会 

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    Event date: 2008

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  52. 糖尿病食事療法における食物繊維摂取量の有効性(第一報)

    山下良子、押田芳治、小池晃彦、石黒哲也

    第51回日本糖尿病学会大会(2008年、東京) 

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    Event date: 2008

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  53. 変形性膝関節症に対するII型コラーゲンを含む健康食品の効果

    小池晃彦、藤掛馨、金村徳相、川田裕樹、吉田隆

    第8回日本抗加齢医学会総会 

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    Event date: 2008

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  54. ICFに基づいた血液透析患者に対するアセスメントツールの開発~2報~

    筒井秀世、山崎親雄、多和田英夫、伊藤晃、後藤慎一、小池晃彦、押田芳治

    第53回日本透析医学会学術集会・総会(2008年、神戸) 

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    Event date: 2008

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  55. カロリー制限と運動負荷が体重、脂肪量、糖代謝に及ぼす影響

    川田裕樹、小池晃彦、姜海英、押田芳治

    第63回日本体力医学会大会 

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    Event date: 2008

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  56. In vivo regulation of glucose uptake in denervated rat skeletal muscle. International conference

    7th World Congress on Aging and Physical Activity 

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    Event date: 2008

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  57. 片足サスペンジョン中のインターバルおよびレッグプレストレーニングが筋機能・形態に及ぼす影響

    秋間広、渡邊航平、片山敬章、石田浩司、小池晃彦

    第63回日本体力医学会大会 

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    Event date: 2008

    Language:Japanese  

  58. Effect of intensive interval cycling training during unilateral lower limb unloading on aerobic capacity.

    62nd Annual Meeting of Japanese Society of Physical Fitness and Sports Medicine 

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    Event date: 2007.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  59. 片足サスペンション中の低頻度インターバルトレーニングが筋機能・形態に及ぼす影響

    秋間広、渡邊航平、白斯琴図雅、片山敬章、石田浩司、小池晃彦

    第62回日本体力医学会大会 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  60. 片足サスペンション中のインターバルトレーニングが有酸素運動能力に及ぼす効果‐トレーニング頻度の違いによる影響について‐

    片山敬章、佐藤耕平、堀田典生、石田浩司、渡邊航平、増田和美、宮地元彦、小池晃彦、秋間広

    第62回日本体力医学会大会 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  61. カロリー制限と運動負荷がラットの体重と副睾丸脂肪量に及ぼす影響

    川田裕樹、小池晃彦、久保田正和、押田芳治

    第62回日本体力医学会大会 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  62. 片足サスペンション中のインターバルトレーニングが漸増負荷運動時の筋動員に及ぼす影響

    渡邊航平、白斯琴図雅、片山敬章、石田浩司、小池晃彦、秋間広

    第62回日本体力医学会大会 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  63. 糖尿病患者における血清シスタチンC濃度(Cys-C)の経時的変化

    後藤慎一、佐々木洋光、渡邊有三、大澤功、小池晃彦、押田芳治

    第50回日本糖尿病学会大会 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  64. 坐骨神経切断による筋萎縮がin vivoにおける骨格筋への糖取り込みおよびインスリンシグナル分子に及ぼす影響

    川田裕樹、久保田正和、李萍、小池晃彦、押田芳治

    第50回日本糖尿病学会大会 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  65. 高果糖摂取ラットでの非拘束覚醒下グルコースクランプ時のインスリンシグナル解析

    第50回日本糖尿病学会大会 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

    李萍、小池晃彦、川田裕樹、押田芳治

  66. 糖尿病患者における血清シスタチンC(Cys-C)の変化量と臨床背景

    後藤 慎一、佐々木洋光、大澤 功、小池 晃彦、押田 芳治

    第54回日本臨床検査医学会学術集会(2007年、大阪) 

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    Event date: 2007

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  67. MELAS, NARP変異を有するサイブリッドにおけるアミノ酸飢餓応答

    藤田泰典、伊藤雅史、野澤義則、小池晃彦、押田芳治、田中雅嗣

    第80回日本生化学会 

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    Event date: 2007

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  68. Intensive interval training prevents muscle atrophy during unloading. International conference

    The 54th Annual Meeting of American College of Sports Medicine 

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    Event date: 2007

    Language:English   Presentation type:Oral presentation (general)  

  69. 糖尿病性腎症の臨床的背景がシスタチンC(Cys-C)レベルに与える影響

    後藤慎一、佐々木洋光、大澤功、小池晃彦、押田芳治

    第53回日本臨床検査医学会学術集会 

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    Event date: 2006

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  70. 高齢者主介護者の栄養・健康状態に関する検討

    榎裕美、葛谷雅文、神田茂、鈴木祐介、益田雄一郎、井澤幸子、平川仁尚、小池晃彦、岡田希和子、井口昭久

    第48回日本日本老年医学会大会 

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    Event date: 2006

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  71. 片足サスペンション中のインターバルトレーニングが筋機能・形態に及ぼす影響

    秋間広、堀田典生、佐藤耕平、石田浩司、片山敬章、小池晃彦

    第61回日本体力医学会大会(2006年、神戸) 

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    Event date: 2006

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  72. 片足サスペンション中のインターバルトレーニングが運動時の呼吸循環応答に及ぼす影響

    佐藤耕平、堀田典生、片山敬章、石田浩司、小池晃彦、秋間広

    第61回日本体力医学会大会 

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    Event date: 2006

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  73. 坐骨神経切断が骨格筋への糖取り込みとインスリンシグナル伝達機構に及ぼす影響。

    川田裕樹、久保田正和、小池晃彦、押田芳治

    第61回日本体力医学会大会 

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    Event date: 2006

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  74. 糖尿病治療にICFを用いることの有用性の検討

    筒井秀代、小池晃彦、押田芳治

    第49回日本糖尿病学会大会 

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    Event date: 2006

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  75. 10日間の水泳トレーニングと低糖質食摂取がラット骨格筋のGLUT-4蛋白量に及ぼす影響

    久保田正和、越中敬一、川田裕樹、小池晃彦、押田芳治

    第49回日本糖尿病学会大会 

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    Event date: 2006

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  76. 高果糖誘発インスリン抵抗性ラットに対するARBの効果

    李萍、久保田正和、川田裕樹、小池晃彦、押田芳治

    第49回日本糖尿病学会大会 

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    Event date: 2006

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  77. 健康スポーツ科学講義に対する学生アンケート

    石黒洋、近藤孝晴、押田芳治、小川豊昭、津田均、小池晃彦、山本明子、古橋忠晃

    第43回全国大学保健管理研究集会 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  78. 片足サスペンションによるヒト骨格筋の機能と形態の変化

    秋間広、堀田典生、片山敬章、石田浩司、小池晃彦、増田和美、宮地元彦

    第60回日本体力医学会大会 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  79. Effect of unilateral lower limb suspension on the oxygen uptake kinetics at the start of exercise.

    The 6th International Head-Out Water Immersion Symposium 

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    Event date: 2005

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  80. The influence of unilateral lower limb suspension on cardiorespiratory response during exercise. International conference

    The 53rd Annual Meeting of American College of Sports Medicine 

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    Event date: 2005

    Language:English   Presentation type:Oral presentation (general)  

  81. Neuromuscular adaptations to unilateral lower limb suspension in humans.

    The 6th International Head-Out Water Immersion Symposium 

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    Event date: 2005

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  82. 訪問看護サービス利用者、未利用者の背景比較―在宅療養高齢者の縦断調査研究を基にー

    葛谷雅文、益田雄一郎、平川仁尚、岩田充永、榎裕美、長谷川潤、小池晃彦、前田恵子、井口昭久

    第47回日本老年医学界学術集会 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  83. 健常高齢者における咀嚼能力と栄養状態および身体機能との関連

    岡田希和子、葛谷雅文、井澤幸子、小池晃彦、鈴木祐介、梅垣宏行、菊谷武、徳本匠、佐藤誠、井口昭久

    第47回日本老年医学界学術集会・総会 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  84. デイケア利用者のMini Nutritional Assessment(MNA)による調査の検討

    井澤幸子、葛谷雅文、岡田希和子、榎裕美、小池晃彦、神田茂、井口昭久

    第47回日本老年医学界学術集会・総会 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  85. 片足サスペンションによる運動時の呼吸循環応答の変化

    佐藤耕平、片山敬章、堀田典夫、石田浩司、小池晃彦、宮地元彦、増田和美、秋間広

    第60回日本体力医学会大会 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  86. 片足サスペンションによる運動開始時の酸素摂取動態の変化

    堀田典夫、佐藤耕平、片山敬章、秋間広、小池晃彦、増田和美、宮地元彦、石田浩司

    第60回日本体力医学会大会 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  87. 片足サスペンションによる運動開始直後の呼吸・循環応答の変化

    石田浩司、堀田典夫、佐藤耕平、片山敬章、小池晃彦、増田和美、宮地元彦、秋間広

    第60回日本体力医学会大会 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  88. 低強度・長時間水泳トレーニングが低糖質食摂取ラット骨格筋のインスリン作用に及ぼす影響

    久保田正和、越中敬一、川田裕樹、小池晃彦、押田芳治

    第60回日本体力医学会大会 

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    Event date: 2005

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  89. 比較的身体的健常高齢者におけるホモシステイン濃度決定因子と認知機能、うつへの影響の検討

    小池晃彦、葛谷雅文、神田茂、岡田希和子、井澤幸子、井口昭久

    第46回日本老年医学学術集会 

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    Event date: 2004

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  90. MMP‐2遺伝子欠損変異マウスにおける下肢虚血後の血管新生障害

    前田恵子、葛谷雅文、佐々木健、成憲武、神田茂、小池晃彦、森典華、柴田たみ、林真由美

    第35回日本動脈硬化学会 

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    Event date: 2003

    Language:Japanese  

  91. 大学病院老年科病棟における入院患者の栄養状況把握の現状

    前田恵子、葛谷雅文、神田茂、小池晃彦、山田素宏、井口昭久

    第45回日本老年医学会 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  92. じょくそうしん出液中のエラスターゼ活性に関する研究

    阿井信吾、葛谷雅文、神田茂、小池晃彦、前田恵子、井口昭久

    第45回日本老年医学会 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  93. 日本人高齢者のための総合的簡易栄養評価法の有効性の検討

    神田茂、葛谷雅文、鈴木裕介、佐竹昭介、浅井俊亘、小池晃彦、井口昭久

    第45回日本老年医学会(2003年、名古屋) 

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    Event date: 2003

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  94. Essential Role of MT1-MMP in Migration of Human Microvascular Endothelial Cells, International conference

    41st Annual meeting The American Society for Cell Biology 

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    Event date: 2001

    Language:English   Presentation type:Poster presentation  

  95. MT1-MMP and MMP-2 regulate migration of human microvascular endothelial cells in 3-dimensional collagen but not on 2-dimensional collagen. International conference

    Frontiers In Cardiovascular Research 

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    Event date: 2001

    Language:English   Presentation type:Oral presentation (invited, special)  

  96. Differential Expression of Matrix Metalloproteinases by Human Microvascular Endothelial Cells on 2-dimensional and in 3-dimentinal collagen. International conference

    ECM2000:International Conferences on Biology and Pathology of the Extracellular Matrix 

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    Event date: 2000

    Language:English   Presentation type:Oral presentation (invited, special)  

  97. pp60v-srcによるカドヘリン依存性細胞間接着阻害機構のDominant negative rasを用いた解析

    小池晃彦、浜口道成

    第69回日本生化学会 

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    Event date: 1996

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  98. P21RAS in the inhibition of cadherin-dependent cell Aggregation in Src transformed cells International conference

    12th Annual Meetings on Oncogenes. 

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    Event date: 1996

    Language:English   Presentation type:Poster presentation  

  99. Src癌化細胞でのカドヘリン依存性細胞間接着阻害におけるp21rasの役割

    第55回日本癌学会総会 

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    Event date: 1996

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  100. Src癌化線維芽細胞におけるホスホリパーゼC-γ1のチロシンリン酸化の検討

    小池晃彦、浜口道成、坂野喜子、野澤義則

    第67回日本生化学学会 

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    Event date: 1994

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  101. SCF/c-kit receptor-mediated arachidonic acid liberation in rat mast cells. International conference

    8th International Conference of the International Society of Differentiation 

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    Event date: 1994

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  102. Stem Cell Factor(SCF)刺激によるラット腹腔マスト細胞の膜リン脂質代謝応答

    小池晃彦、平井浩一、森田寛、野澤義則

    第56回日本生化学学会中部支部例会 

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    Event date: 1993

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  103. Sustained diacylglycerol production by phospholipase D pathway in c-kit/SCF receptor stimulation in mast cells. International conference

    9th Annual Meetings on Oncogenes. 

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    Event date: 1993

    Language:English   Presentation type:Poster presentation  

  104. Stem Cell Factor(SCF)刺激によるラット腹腔マスト細胞の膜リン脂質代謝応答

    小池晃彦、平井浩一、森田寛、野澤義則

    第65回日本生化学学会 

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    Event date: 1992

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  105. TXA2によるヒト血小板活性化に対するゲニステインの抑制機構

    小池晃彦、中島茂、野澤義則

    第64回日本生化学学会 

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    Event date: 1991

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  106. Signal transduction of endothelins in neuroblastoma NG108-15 cells. International conference

    13th International Society for Neurochemistry 

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    Event date: 1991

    Language:English   Presentation type:Poster presentation  

  107. ヒト巨核球系細胞株(CMK)におけるリン脂質代謝

    小池晃彦、中島茂、野澤義則

    第14回日本血栓止血学会学術集会 

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    Event date: 1991

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  108. ゲニステインのヒト血小板活性化抑制機構の解析

    中島茂、小池晃彦、野澤義則

    第13回日本血栓止血学会学術集会 

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    Event date: 1990

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  109. リウマチ性硬髄膜炎の1例

    小池晃彦、小西康弘、八田和大、今中孝信

    第34回日本リウマチ学会総会 

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    Event date: 1990

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  110. ゲニステインのヒト血小板活性化抑制機構

    中島茂、小池晃彦、野澤義則

    第12回生体膜と薬物の相互作用シンポジウム 

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    Event date: 1990

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  111. 慢性関節リウマチにてステロイド漸減中、多発性化膿性滑液包炎、化膿性脊椎炎を合併した1症例

    小池晃彦、久須美房子、富井啓介、八田和大、今中孝信

    第130回日本内科学会近畿地方会 

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    Event date: 1989

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 7

  1. インスリン抵抗性制御の脳と骨格筋での作用-効果的な有酸素運動法の検討

    2019 - 2020

    日本医学会総会記念医学振興基金 研究助成 

  2. サルコペニア肥満における運動処方の検討

    2017 - 2018

    愛知健康増進財団 医学研究・健康増進活動等助成 

  3. サルコペニアモデルマウスの骨格筋における運動誘発性蛋白合成シグナルの解析

    2014 - 2015

    中京長寿医療研究推進財団助成 

    小池晃彦

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    Grant type:Competitive

    Grant amount:\300000

  4. 老化促進マウスの加齢性骨格筋減少の対するエイコサペンタエン酸の効果

    2014

    日本医学会総会記念医学振興基金海外学会等参加費用援助助成 

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    Authorship:Principal investigator 

    Grant amount:\300000

  5. エイコサペンタエン酸による抗炎症作用とインスリン抵抗性改善作用は老化促進マウスの加齢性筋肉減少症を改善するか?

    2012.1 - 2012.12

    三井住友海上福祉財団 研究助成 

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    Grant type:Competitive

  6. エイコサペンタエン酸による抗炎症作用とインスリン抵抗性改善作用は老化促進マウスの加齢性筋肉減少症を改善するか?

    2012.1 - 2012.12

    学内共同研究 

  7. メタボリック症候群でのインスリン抵抗性発現メカニズムの解明-高果糖食ラットでのARBならびにアロプリノールの効果―

    2010.4 - 2011.3

    学内共同研究 

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    昭和報公会研究助成 500千円

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KAKENHI (Grants-in-Aid for Scientific Research) 14

  1. スポーツ科学の糖尿病運動療法への応用-骨格筋・脳インスリン抵抗性を指標にして

    Grant number:20K11386  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    小池 晃彦, 都築 孝允, 坂野 僚一

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    Authorship:Principal investigator 

    Grant amount:\4030000 ( Direct Cost: \3100000 、 Indirect Cost:\930000 )

    運動療法の健康に及ぼす効果は、運動強度や量と必ずしも相関しないことが近年報告されている。申請者らも、レジスタンス運動による筋肥大を、高強度ではなく低強度の有酸素運動が促進することを報告した。本研究では、骨格筋と脳のインスリン抵抗性発現に対する①低強度運動と短時間高強度間欠的運動の抑制効果、②運動実施時間が及ぼす影響、③希少糖プシコースと強制または自発運動の併用による抑制効果を検討する。インスリン抵抗性の改善は、糖尿病のみならず認知症、サルコペニアの予防につながる可能性がある。スポーツ科学の知見を利用し、より実践しやすい運動方法が明らかになれば、運動療法の活用を促進し健康寿命の延伸に貢献できる。
    運動を模倣する効果をもつ栄養素あるいは薬物は、生活習慣病や老化を予防する可能性がある。希少糖アリュロースを用いた検討では、高ショ糖食と高脂肪食誘発肥満ラットモデルにおいて、高インスリン正常血糖クランプ法と骨格筋細胞内シグナルを解析することで、骨格筋でのインスリン抵抗性を改善すること、その機序には、内臓脂肪の減少にともなう慢性炎症抑制効果が関与することを報告した。一方で、高ショ糖食と高脂肪食肥満モデルでの知見を比較することで、アリュロースの効果には、肥満改善とは独立した機序もあると考えられる。アリュロースは、果糖のエピマーであり、甘味料に含まれる高果糖摂取に対する効果とも合わせて検討することがその機序を明らかにする上で有効である。
    私たちは、普通食で飼育したマウスモデルにおいても、アリュロースがインスリン抵抗性を改善することを示すデータを得ている。さらに、アリュロースが、マウスの運動持久力、消耗運動後の疲労回復能などの運動パーフォーマンスをあげることを報告した。このアリュロースの効果の機序は、骨格筋細胞内のシグナル解析の検討より、有酸素トレーニングと共通していると考えられる。筋・肝臓へのグリコーゲン貯蔵増加や遊離脂肪酸の利用増加によるエネルギー産生の効率化が機序として挙げられるが、私たちの研究で示されたアリュロースによる運動能亢進においては、後者の関与が重要であることが示唆された。これらの知見は、アリュロースが糖代謝の改善にとどまらず、運動能の向上や、運動模倣薬としての作用、さらには、抗老化作用を有する可能性を示している。運動とアリュロースの併用は、これらの作用を効果的に高めることが予想される。
    高ショ糖食、高脂肪食負荷による肥満モデルでのアリュロースによるインスリン抵抗性改善作用に加え、アリュロースの運動模倣薬としての可能性を明らかにできた。
    今後は、アリュロースが、異なる栄養素による代謝異常や運動トレーニング効果に与える影響をより詳細に検討していくことで、その有効性や利用方法を明らかにする。運動模倣薬としての可能性もあり、運動による効果との比較、運動との併用効果、その効果のメカニズムについて検討をすすめる。

  2. 骨格筋を標的とした有酸素運動とEPAによるメタボリック症候群での介入の展開

    2017.4 - 2020.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  3. サルコペニア(老化による筋肉減少)でのインスリン抵抗性と慢性炎症による制御の解析

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  4. 若年肥満男性に対する効果的な運動・栄養処方の検討-インスリン抵抗性を指標として

    2009.4 - 2012.3

    科学研究費補助金  基盤研究(C)

  5. 骨格筋萎縮における細胞外基質の役割ー3次元細胞培養と廃用筋萎縮動物での検討

    2006.4 - 2008.3

    科学研究費補助金  基盤研究(C)

    小池 晃彦

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    Authorship:Principal investigator 

  6. ホスファチジルイノシトール4,5-二リン酸による細胞の形態・接着の制御機構

    1996.4 - 1997.3

    科学研究費補助金  奨励研究A

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    Authorship:Principal investigator 

  7. Srcキナーゼの活性化と浸潤・転移に決定的なシグナル伝達系の解析

    1996.4 - 1997.3

    科学研究費補助金  重点領域研究

    浜口道成

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    Authorship:Coinvestigator(s) 

  8. チロシンリン酸化を介する細胞形態・接着制御機構の解析

    1996.4 - 1997.3

    科学研究費補助金  基盤研究C

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    Authorship:Coinvestigator(s) 

  9. 細胞の形態・接着を制御するシグナル伝達系の研究

    1996.4 - 1997.3

    科学研究費補助金  国際学術研究

    浜口道成

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    Authorship:Coinvestigator(s) 

  10. Spatiotemporal evaluation of intramuscular blood flow during exercise by ultrasound power Doppler technique: comparison of elderly and young subjects

    Grant number:22K19728  2022.6 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Coinvestigator(s) 

  11. インスリン抵抗性制御の脳と骨格筋での作用-効果的な有酸素運動法の検討

    2019 - 2020

    日本医学会総会記念医学振興基金 研究助成 

  12. Effect of aerobic training and EPA on skeletal muscle in metabolic syndrome

    Grant number:17K01842  2017.4 - 2020.3

    Koike Teruhiko

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    Sarcopenic obesity is a condition in which muscle mass loss due to aging and visceral fat accumulation coexist. We investigated whether chronic inflammation due to obesity causes a decrease in skeletal muscle synthesis and a muscle mass loss in a diet-induced obesity model and an aging-promoting model. The effect of aerobic exercise on the changes in muscle mass was also tested. Chronic inflammation and insulin resistance increase in obesity and aging, but the administration of a high-fat diet did not cause a decrease in skeletal muscle synthesis, and the combination with aerobic exercise by spinning wheel increased muscle mass. Therefore, a combination of high-fat diet and aerobic exercise may be effective in preventing sarcopenia, but such intervention should not increase ectopic fat in muscle or metabolic abnormalities.

  13. 骨格筋を標的とした有酸素運動とEPAによるメタボリック症候群での介入の展開

    2017.4 - 2020.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Competitive

  14. サルコペニア肥満における運動処方の検討

    2017 - 2018

    愛知健康増進財団  愛知健康増進財団 医学研究・健康増進活動等助成 

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Teaching Experience (On-campus) 11

  1. 基礎医学セミナー(医学部3年)

    2021

  2. 生活習慣病に関する講義

    2021

  3. Young Leaders Program

    2021

  4. ベーシックトレーニング

    2021

  5. ベーシックトレーニング

    2020

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    博士課程の学生に対する実験手技に関する講義、実習

  6. Young Leaders Program

    2020

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    修士コースであるYLPでの生活習慣に関する講義

  7. 生活習慣病に関する講義

    2020

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    生活習慣病に関する講義の一コマを担当

  8. 基礎医学セミナー(医学部3年)

    2020

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    10月から3月まで、半年にわたって基礎研究を指導し、発表を行う。

  9. Health and Sports Science: Lecture

    2011

  10. Health and Sports Science: Lecture

    2011

  11. Health and Sports Science: Lecture

    2011

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Teaching Experience (Off-campus) 10

  1. Young Leaders Program

    2021 Nagoya University)

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    Level:Undergraduate (liberal arts) 

  2. 基礎医学セミナー(医学部3年)

    2021 Nagoya University)

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    Level:Undergraduate (liberal arts) 

  3. ベーシックトレーニング

    2021 Nagoya University)

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    Level:Undergraduate (liberal arts) 

  4. Young Leaders Program

    2020 Nagoya University)

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    Level:Postgraduate 

    修士コースであるYLPでの生活習慣に関する講義

  5. 基礎医学セミナー(医学部3年)

    2020 Nagoya University)

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    Level:Undergraduate (specialized) 

    10月から3月まで、半年にわたって基礎研究を指導し、発表を行う。

  6. ベーシックトレーニング

    2020 Nagoya University)

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    Level:Postgraduate 

    博士課程の学生に対する実験手技に関する講義、実習

  7. 介護予防

  8. 認知症

  9. 高齢者の特徴

  10. 高齢者の救急

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Social Contribution 11

  1. 健康長寿のための運動の意義

    Role(s):Lecturer

    名古屋大学  ホームカミングデイ  2021.9

  2. 健康長寿のための運動の意義

    Role(s):Lecturer

    名古屋大学  ホームカミングデイ  2021.9

  3. 身近にある依存症

    Role(s):Appearance

    CBC  きく!ラジオ「健康生活」  2022.1

  4. 身近にある依存症

    Role(s):Appearance

    CBC  きく!ラジオ「健康生活」  2022.1

  5. 健康長寿のための運動-Sports is Medicine

    Role(s):Appearance

    CBC  きく!ラジオ「健康生活」  2021.5

  6. 健康長寿のための運動-Sports is Medicine

    Role(s):Appearance

    CBC  きく!ラジオ「健康生活」  2021.5

  7. 人生100年時代を健康に生きる-Exercise is Medicine

    Role(s):Lecturer

    SAM日本チャプター名古屋支部例会  2021.3

  8. 人生100年時代を健康に生きる-Exercise is Medicine

    Role(s):Lecturer

    SAM日本チャプター名古屋支部例会  2021.3

  9. Withコロナ時代の健康と運動

    Role(s):Appearance

    CBC  2020.10

  10. スポーツは百薬の長!スポーツ科学を利用する

    Role(s):Lecturer

    富士通東海パートナー会3部門合同講演会  2020.2

  11. スポーツは百薬の長!スポーツ科学を利用する

    Role(s):Lecturer

    富士通東海パートナー会3部門合同講演会  2020.2

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