Updated on 2021/03/24

写真a

 
SHOJI, Osami
 
Organization
Nagoya University Graduate School of Science Division of Material Science Inorganic and Analytical Chemistry Professor
Title
Professor
Contact information
メールアドレス

Degree 1

  1. Doctor of engineering ( 2002.3   Chiba University ) 

Research Interests 1

  1. 生体関連化学 生物無機化学 蛋白工学 酵素科学

Research Areas 1

  1. Others / Others  / Chemistry Related to Living Body

Current Research Project and SDGs 1

  1. ヘム蛋白の機能変換とその制御に関する研究

Research History 7

  1. Associate professor at Graduate School of Science, Nagoya University

    2013.4

      More details

    Country:Japan

  2. Assistant Professor at Graduate School of Science, Nagoya University

    2008.10 - 2013.3

      More details

    Country:Japan

  3. Assistant Professor at Research Center for Materials Science, Nagoya University

    2007.12 - 2008.9

      More details

    Country:Japan

  4. JSPS Postdoctoral fellow

    2006.4 - 2007.11

      More details

    Country:Japan

  5. Postdoctoral fellow at Research Center for Materials Science, Nagoya University

    2005.4 - 2006.3

      More details

    Country:Japan

  6. Postdoctoral fellow at Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan

    2004.4 - 2005.3

      More details

    Country:Japan

  7. Postdoctoral fellow of the Core Research for Evolutional Science and Technology (CREST) project of Japan Science and Technology Agency (JST)

    2002.4 - 2004.3

      More details

    Country:Japan

▼display all

Education 3

  1. Chiba University   Graduate School, Division of National Science and Technology   Graduate school of Science and Technology

    1999.4 - 2002.3

      More details

    Country: Japan

  2. Chiba University   Graduate School, Division of National Science and Technology   Graduate School of Science and Technology

    1997.4 - 1999.3

      More details

    Country: Japan

  3. Chiba University   Faculty of Engineering   Department of Applied Chemistry

    1993.4 - 1997.3

      More details

    Country: Japan

Professional Memberships 5

  1. The Chemical Society of Japan

  2. Division of biofunctional chemistry, The Chemical Society of Japan

  3. Japan Society of Coordination Chemistry

  4. The Society of Polymer Science, Japan

  5. American Chemical Society

Awards 5

  1. 日本化学会第93回春季年会 第27回若い世代の特別講演会賞

    2013.3   日本化学会  

     More details

    Country:Japan

  2. 第5回バイオ関連化学シンポジウム講演賞

    2011.9   生体機能関連化学部会  

     More details

    Country:Japan

  3. Poster award from 16th International Conference on Cytochrome P450

    2009.7   16th International Conference on Cytochrome P450  

     More details

    Country:Japan

  4. EXCELLENT LECTURE AWARD from the Chemical Society of Japan

    2007.5   The Chemical Society of Japan  

     More details

    Country:Japan

  5. NANOHANA VENTURE AWARD

    2000.12   Center for Electronics and Photonics Chiba University-Venture Business Laboratory  

     More details

    Country:Japan

 

Papers 59

  1. Expanding the applicability of cytochrome P450s and other haemoproteins Reviewed

    Ariyasu Shinya, Stanfield Joshua Kyle, Aiba Yuichiro, Shoji Osami

    CURRENT OPINION IN CHEMICAL BIOLOGY   Vol. 59   page: 155-163   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cbpa.2020.06.010

    Web of Science

  2. Investigation of the Characteristics of NLS-PNA: Influence of NLS Location on Invasion Efficiency Reviewed

    Aiba Yuichiro, Urbina Gerardo, Shibata Masanari, Shoji Osami

    APPLIED SCIENCES-BASEL   Vol. 10 ( 23 ) page: 8663   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/app10238663

    Web of Science

  3. Iron(III) 5,15-Diazaporphyrin Catalysts for the Direct Oxidation of C(sp(3))-H Bonds

    Nishimura Tsubasa, Ikeue Takahisa, Shoji Osami, Shinokubo Hiroshi, Miyake Yoshihiro

    INORGANIC CHEMISTRY   Vol. 59 ( 21 ) page: 15751-15756   2020.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.inorgchem.0c02166

    Web of Science

  4. Enhanced cis- and enantioselective cyclopropanation of styrene catalysed by cytochrome P450BM3 using decoy molecules Reviewed

    Suzuki Kazuto, Shisaka Yuma, Stanfield Joshua Kyle, Watanabe Yoshihito, Shoji Osami

    CHEMICAL COMMUNICATIONS   Vol. 56 ( 75 ) page: 11026-11029   2020.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d0cc04883f

    Web of Science

  5. Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3 Reviewed

    Yonemura Kai, Ariyasu Shinya, Stanfield Joshua Kyle, Suzuki Kazuto, Onoda Hiroki, Kasai Chie, Sugimoto Hiroshi, Aiba Yuichiro, Watanabe Yoshihito, Shoji Osami

    ACS CATALYSIS   Vol. 10 ( 16 ) page: 9136-9144   2020.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acscatal.0c01951

    Web of Science

  6. Control of microenvironment around enzymes by hydrogels

    Kobayashi Yuichiro, Kohara Kenji, Kiuchi Yusuke, Onoda Hiroki, Shoji Osami, Yamaguchi Hiroyasu

    CHEMICAL COMMUNICATIONS   Vol. 56 ( 49 ) page: 6723-6726   2020.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d0cc01332c

    Web of Science

  7. Crystals in Minutes: Instant On-Site Microcrystallisation of Various Flavours of the CYP102A1 (P450BM3) Haem Domain Reviewed

    Stanfield Joshua Kyle, Omura Keita, Matsumoto Ayaka, Kasai Chie, Sugimoto Hiroshi, Shiro Yoshitsugu, Watanabe Yoshihito, Shoji Osami

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 59 ( 19 ) page: 7611-7618   2020.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201913407

    Web of Science

  8. Cationic guanine: positively charged nucleobase with improved DNA affinity inhibits self-duplex formation Reviewed

    Hibino Masaki, Aiba Yuichiro, Shoji Osami

    CHEMICAL COMMUNICATIONS   Vol. 56 ( 17 ) page: 2546-2549   2020.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d0cc00169d

    Web of Science

  9. Development of a High-Pressure Reactor Based on Liquid-Flow Pressurisation to Facilitate Enzymatic Hydroxylation of Gaseous Alkanes Reviewed

    Ariyasu Shinya, Kodama Yusaku, Kasai Chie, Cong Zhiqi, Stanfield Joshua Kyle, Aiba Yuichiro, Watanabe Yoshihito, Shoji Osami

    CHEMCATCHEM   Vol. 11   page: 4709-4714   2019.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cctc.201901323

    Web of Science

  10. Hijacking the Heme Acquisition System of Pseudomonas aeruginosa for the Delivery of Phthalocyanine as an Antimicrobial Reviewed

    Shisaka Yuma, Iwai Yusuke, Yamada Shiho, Uehara Hiromu, Tosha Takehiko, Sugimoto Hiroshi, Shiro Yoshitsugu, Stanfield Joshua K., Ogawa Kazuya, Watanabe Yoshihito, Shoji Osami

    ACS CHEMICAL BIOLOGY   Vol. 14 ( 7 ) page: 1637-1642   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acschembio.9b00373

    Web of Science

  11. Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes Reviewed

    Sakakibara Erika, Shisaka Yuma, Onoda Hiroki, Koga Daiki, Xu Ning, Ono Toshikazu, Hisaeda Yoshio, Sugimoto Hiroshi, Shiro Yoshitsugu, Watanabe Yoshihito, Shoji Osami

    RSC ADVANCES   Vol. 9 ( 32 ) page: 18697-18702   2019.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c9ra02872b

    Web of Science

  12. The effect of decoy molecules on the activity of the P450Bm3 holoenzyme and a heme domain peroxygenase variant Reviewed

    Dezvarei Shaghayegh, Shoji Osami, Watanabe Yoshihito, Bell Stephen G.

    CATALYSIS COMMUNICATIONS   Vol. 124   page: 97-102   2019.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.catcom.2019.03.004

    Web of Science

  13. Hoodwinking Cytochrome P450BM3 into Hydroxylating Non-Native Substrates by Exploiting Its Substrate Misrecognition Reviewed

    Shoji Osami, Aiba Yuichiro, Watanabe Yoshihito

    ACCOUNTS OF CHEMICAL RESEARCH   Vol. 52 ( 4 ) page: 925-934   2019.3

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.accounts.8b00651

    Web of Science

  14. Whole-Cell Biotransformation of Benzene to Phenol Catalysed by Intracellular Cytochrome P450BM3 Activated by External Additives Reviewed

    M. Karasawa, J. K. Stanfield, S. Yanagisawa, O. Shoji, Y. Watanabe

    Angew. Chem. Int. Ed.   Vol. 57   page: 12264-12269   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.1002/anie.201883861

  15. Peptide Nucleic Acid Conjugated with Ruthenium-Complex Stabilizing Double-Duplex Invasion Complex Even under Physiological Conditions Reviewed

    Hibino Masaki, Aiba Yuichiro, Watanabe Yoshihito, Shoji Osami

    CHEMBIOCHEM   Vol. 19 ( 15 ) page: 1601-1604   2018.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbic.201800256

    Web of Science

  16. Metabolic enhancement of 2,3 ',4,4 ',5-pentachlorobiphenyl (CB118) using cytochrome P450 monooxygenase isolated from soil bacterium under the presence of perfluorocarboxylic acids (PFCAs) and the structural basis of its metabolism

    Goto Erika, Haga Yuki, Kubo Makoto, Itoh Toshimasa, Kasai Chie, Shoji Osami, Yamamoto Keiko, Matsumura Chisato, Nakano Takeshi, Inui Hideyuki

    CHEMOSPHERE   Vol. 210   page: 376-383   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.chemosphere.2018.07.026

    Web of Science

  17. Dual-Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase Reviewed

    Ma Nana, Chen Zhifeng, Chen Jie, Chen Jingfei, Wang Cong, Zhou Haifeng, Yao Lishan, Shoji Osami, Watanabe Yoshihito, Cong Zhiqi

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 57 ( 26 ) page: 7628-7633   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201801592

    Web of Science

  18. Reconstitution of full-length P450BM3 with an artificial metal complex by utilising the transpeptidase Sortase A Reviewed

    Omura Keita, Aiba Yuichiro, Onoda Hiroki, Stanfield Joshua Kyle, Ariyasu Shinya, Sugimoto Hiroshi, Shiro Yoshitsugu, Shoji Osami, Watanabe Yoshihito

    CHEMICAL COMMUNICATIONS   Vol. 54 ( 57 ) page: 7892-7895   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c8cc02760a

    Web of Science

  19. Hydroxylation of gaseous alkanes and benzene catalyzed by cytochrome P450BM3 using decoy molecules as a substrate analogue

    Shoji Osami, Watanabe Yoshihito

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 255   page: .   2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  20. Switchable stereoselectivity in monooxygenation of non-native substrates by P450BM3 using decoy molecules

    Suzuki Kazuto, Shoji Osami, Stanfield Joshua, Sugimoto Hiroshi, Shiro Yoshitsugu, Watanabe Yoshihito

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 255   page: .   2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  21. Efficient hydroxylation of cycloalkanes by co-addition of decoy molecules to variants of the cytochrome P450 CYP102A1 Reviewed

    S. Dezvarei, H. Onoda, O. Shoji, Y. Watanabe, S. G. Bell

    J. Inorg. Biochem.   Vol. 183   page: 137-145   2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jinorgbio.2018.03.001

  22. α-Oxidative decarboxylation of fatty acids catalysed by cytochrome P450 peroxygenases yielding shorter-alkyl-chain fatty acids Reviewed

    H. Onoda, O.Shoji, K.Suzuki, H.Sugimoto, Y.Shiro, Y.Watanabe

    Catal. Sci. Technol.   Vol. 8 ( 2 ) page: 434-442   2018.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C7CY02263H

  23. Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate Reviewed

    T.Tosha, T. Nomura, T. Nishida, N. Saeki, K. Okubayashi, R. Yamagiwa, M. Sugahara, T. Nakane, K. Yamashita, K. Hirata, G. Ueno, T. Kimura, T. Hisano, K. Muramoto, H. Sawai, H. Takeda, E. Mizohata, A. Yamashita, Y. Kanematsu, Y. Takano, E. Nango, R. Tanaka, O. Nureki, O. Shoji, Y. Ikemoto, H. Murakami, S. Owada, K. Tono, M. Yabashi, M. Yamamoto, H. Ago, S. Iwata, H. Sugimoto, Y. Shiro, M. Kubo

    Nature Communications   Vol. 8 ( 1 ) page: 1585   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-017-01702-1

  24. Inhibiting Aggregation of β-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria Reviewed

    K. Yamamoto, M. Oyaizu, T. Takahashi, Y. Watanabe, O. Shoji

    Chemistry Select   Vol. 2 ( 28 ) page: 9058-9062   2017.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/slct.201700658

  25. Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group Reviewed

    Uehara Hiromu, Shisaka Yuma, Nishimura Tsubasa, Sugimoto Hiroshi, Shiro Yoshitsugu, Miyake Yoshihiro, Shinokubo Hiroshi, Watanabe Yoshihito, Shoji Osami

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 56 ( 48 ) page: 15279-15283   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201707212

    Web of Science

  26. Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives Reviewed

    Shoji Osami, Yanagisawa Sota, Stanfield Joshua Kyle, Suzuki Kazuto, Cong Zhiqi, Sugimoto Hiroshi, Shiro Yoshitsugu, Watanabe Yoshihito

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Vol. 56 ( 35 ) page: 10324-10329   2017.8

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201703461

    Web of Science

  27. Control of stereoselectivity of benzylic hydroxylation catalysed by wild-type cytochrome P450BM3 using decoy molecules Reviewed

    Suzuki Kazuto, Stanfield Joshua Kyle, Shoji Osami, Yanagisawa Sota, Sugimoto Hiroshi, Shiro Yoshitsugu, Watanabe Yoshihito

    CATALYSIS SCIENCE & TECHNOLOGY   Vol. 7 ( 15 ) page: 3332-3338   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c7cy01130j

    Web of Science

  28. Monooxygenation of Nonnative Substrates Catalyzed by Bacterial Cytochrome P450s Facilitated by Decoy Molecules Reviewed

    O. Shoji, Y. Watanabe

    Chemistry Letters   Vol. 46 ( 3 ) page: 278-288   2017.3

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.160963

  29. Use of apomyoglobin to gently remove heme from a H2O2-dependent cytochrome P450 and allow its reconstitution Reviewed

    Chien Shih-Cheng, Shoji Osami, Morimoto Yoshiko, Watanabe Yoshihito

    NEW JOURNAL OF CHEMISTRY   Vol. 41 ( 1 ) page: 302-307   2017.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c6nj02882a

    Web of Science

  30. A Substrate-Binding-State Mimic of H2O2-Dependent Cytochrome P450 Produced by One-point Mutagenesis and Peroxygenation of Non-native Substrates Reviewed

    O. Shoji, T. Fujishiro, K. Nishio, Y. Kano, H. Kimoto, S. Chien, H. Onoda, A. Muramatsu, S. Tanaka, A. Hori, H. Sugimoto, Y. Shiro, Y. Watanabe

    Catal. Sci. Tech.   Vol. 6   page: 5806-5811   2016.8

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C6CY00630B

  31. Improved oxidation of aromatic and aliphatic hydrocarbons using rate enhancing variants of P450Bm3 in combination with decoy molecules Reviewed

    S. D. Munday, O. Shoji, Y. Watanabe, L. L. Wong, S. G. Bell

    Chem. Commun.   Vol. 52   page: 1036-1039   2016.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C5CC09247G

  32. Acetate anion-triggered peroxygenation of non-native substrates by wild-type cytochrome P450s Reviewed

    H. Onoda, O. Shoji, Y. Watanabe

    Dalton Trans   Vol. 44   page: 15316-15323   2015.8

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C5DT00797F

  33. Highly efficient hydroxylation of gaseous alkanes at reduced temperature catalyzed by cytochrome P450BM3 assisted by decoy molecules Reviewed

    N. Kawakami, Z. Cong, O. Shoji, Y. Watanabe

    Journal of Porphyrins and Phthalocyanines   Vol. 19   page: 329-334   2015.3

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1142/S1088424615500145

  34. Activation of Wild-type Cytochrome P450BM3 by the Next Generation of Decoy Molecules: Enhanced Hydroxylation of Gaseous Alkanes and Crystallographic Evidence Reviewed

    Z. Cong, O. Shoji, C. Kasai, N. Kawakami, H. Sugimoto, Y. Shiro, Y. Watanabe

    ACS Catalysis   Vol. 5   page: 150–156   2015.1

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/cs501592f

  35. Bringing out the potential of wild-type cytochrome P450s using decoy molecules: Oxygenation of nonnative substrates by bacterial cytochrome P450s Reviewed

    O. Shoji, Y. Watanabe

    Isr. J. Chem.   Vol. 55 ( 1 ) page: 32–39   2015.1

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ijch.201400096

  36. GluN2B-Selective N-Methyl-d-aspartate (NMDA) Receptor Antagonists Derived from 3-Benzazepines: Synthesis and Pharmacological Evaluation of Benzo[7]annulen-7-amines Reviewed

    A. Benner, A. Bonifazi, C. Shirataki, L. Temme, D. Schepmann, W. Quaglia, O. Shoji, Y. Watanabe, C. Daniliuc, B. Wünsch

    ChemMedChem   Vol. 9 ( 4 ) page: 741-751   2014.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  37. Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp) Bound to Synthetic Metal Complexes Reviewed

    C. Shirataki, O. Shoji, M. Terada, S. Ozaki, H. Sugimoto, Y. Shiro, Y. Watanabe

    Angew. Chem. Int. Ed.   Vol. 53   page: 2862-2866   2014.3

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  38. Peroxygenase reactions catalyzed by cytochromes P450 Reviewed

    O. Shoji, Y. Watanabe

    J. Biol. Inorg. Chem   Vol. 19 ( 4-5 ) page: 529-539   2014.2

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  39. Electronic Control of Discrimination between O2 and CO in Myoglobin Lacking the Distal Histidine Residue Reviewed

    R. Nishimura, T. Shibata, I. Ishigami, T. Ogura, H. Tai, S. Nagao, T. Matsuo, S Hirota, O. Shoji, Y. Watanabe, K. Imai, S. Neya, A. Suzuki, Y. Yamamoto

    Inorg. Chem   Vol. 53   page: 1091–1099   2013.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  40. Highly Selective Hydroxylation of Benzene to Phenol by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules Reviewed

    O. Shoji, T. Kunimatsu, N. Kawakami, Y. Watanabe

    Angew. Chem. Int. Ed.   Vol. 52   page: 6606-6610   2013.6

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  41. Direct hydroxylation of primary carbons in small alkanes by wild-type cytochrome P450BM3 containing perfluorocarboxylic acids as decoy molecules Reviewed

    N. Kawakami, O. Shoji, Y. Watanabe

    Chem. Sci.   Vol. 4   page: 2344-2348   2013.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  42. Chiral-Substrate-Assisted Stereoselective Epoxidation Catalyzed by H2O2-Dependent Cytochrome P450SPα Reviewed

    T. Fujishiro, O. Shoji, N. Kawakami, T. Watanabe, H. Sugimoto, Y. Shiro, Y. Watanabe

    Chemistry-An Asian Journal   Vol. 7 ( 10 ) page: 2286-2293   2012.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  43. Single-step reconstitution of apo-hemoproteins at the disruption stage of Escherichia coli cells Reviewed

    N. Kawakami, O. Shoji, Y.Watanabe

    ChemBioChem   Vol. 13 ( 14 ) page: 2045-2047   2012.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  44. Construction of Biocatalysts Using the Myoglobin Scaffold for the Synthesis of Indigo from Indole Reviewed

    J. Xu, O. Shoji, T. Fujishiro, T. Ohki, T. Ueno, Y. Watanabe

    Catalysis Science & Technology   Vol. 2   page: 739-744   2012.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  45. Molecular Design of Heme Proteins for Future Application Reviewed

    H. Nakajima, O. Shoji, Y. Watanabe

    Catalysis Surveys from Asia   Vol. 15 ( 3 ) page: 134-143   2011.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    This review surveys our recent studies on artificial heme oxygenases, which consists of two topics. The first topic is an artificial peroxidase founded on a thermally tolerant protein, which shows high thermal stability in the catalytic reaction. In the second topic, we describe `Decoy system' that has been developed to transform Cytochrome P450BSβ into a versatile oxygenase.

  46. Crystal structure of H2O2-dependent cytochrome P450SPα with its bound fatty acid substrate: insight into the regioselective hydroxylation of fatty acids at the α position Reviewed

    T. Fujishiro, O. Shoji, S. Nagano, H. Sugimoto, Y. Shiro, Y. Watanabe

    J. Biol. Chem.   Vol. 286   page: 29941-29950   2011.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  47. Use of Perfluoro Carboxylic Acids Trick Cytochrome P450BM3 into Initiating Hydroxylation of Gaseous Alkanes Reviewed

    N. Kawakami, O. Shoji, Y. Watanabe

    Angew.Chem.Int.Ed   Vol. 50   page: 5315-5318   2011.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    It has long been believed that the fatty acid hydroxylase wild-type P450BM3 is unable to oxidize gaseous alkanes. However, the simple addition of a perfluorocarboxylic acid as a dummy substrate to initiate the P450BM3 catalytic cycle enabled the efficient hydroxylation of butane and propane (see picture).

  48. Design of H2O2-Dependent Oxidation Catalyzed by Hemoproteins Reviewed

    O. Shoji, Y. Watanabe

    Metallomics   Vol. 3   page: 379-388   2011.2

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    The monooxygenese activity of cytochrome P450 is successfully introduced into myoglobin by rational design of its active site. Introduction of an aromatic ring, tryptophan, near the heme by site-directed mutagenesis resulted in the hydroxylation of tryptophan at the C6 position by using an almost stoichiometric amount of H(2)O(2). We also altered the substrate specificity of H(2)O(2)-dependent P450 by employing a simple substrate trick. Although P450(BSβ) exclusively catalyzes peroxygenation of long-alkyl-chain fatty acids, oxidation of non-natural substrates such as styrene, ethylbenzene, and 1-methoxynaphthalen are catalyzed by P450(BSβ) in the presence of decoy molecules having a carboxyl group. Advantageously, the substrate specificity of P450(BSβ) can be altered by simply adding the decoy molecule without replacing any amino acid residues. Moreover, the stereoselectivity can be controlled by changing the structure of the decoy molecule. The crystal structure analysis of the decoy molecule bound-form of P450(BSβ) shows that P450(BSβ) accepts the decoy molecule, whose carboxylate is located at the same position to that of long-alkyl-chain fatty acid.

  49. Non-covalent modification of the active site of cytochrome P450 for inverting the stereoselectivity of monooxygenation Reviewed

    Takashi Fujishiro, Osami Shoji, Yoshihito Watanabe

    Tetrahedron Letters   Vol. 53 ( 3 ) page: 395-397   2010.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The enantioselectivity in the sulfoxidation of thioanisole catalyzed by cytochrome P450BSβ with a decoy molecule, a dummy molecule of the natural substrate, can be inverted by changing the structure of the decoy molecule. The methodology demonstrated herein shows the potential for controlling the stereoselectivity of biocatalysts without any mutagenesis.

  50. Understanding substrate misrecognition of hydrogen peroxide dependent cytochrome P450 from Bacillus subtilis Reviewed

    Osami Shoji, Takashi Fujishiro, Shingo Nagano, Shota Tanaka, Takuya Hirose, Yoshitsugu Shiro, Yoshihito Watanabe

    J. Biol. Inorg. Chem.   Vol. 15 ( 8 ) page: 1331-1339   2010.8

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Cytochrome P450(BSβ), a H(2)O(2)-dependent cytochrome P450 catalyzing the hydroxylation of long-alkyl-chain fatty acids, lacks the general acid-base residue around the heme, which is indispensable for the efficient generation of the active species using H(2)O(2). On the basis of the crystal structure of the palmitic acid bound form of cytochrome P450(BSβ), it was suggested that the role of the general acid-base function was provided by the carboxylate group of fatty acids. The participation of the carboxylate group of the substrate was supported by the fact that cytochrome P450(BSβ) can catalyze oxidations of nonnatural substrates such as styrene and ethylbenzene in the presence of a series of short-alkyl-chain carboxylic acids as a dummy molecule of fatty acid. We refer to a series of short-alkyl-chain carboxylic acids as a "decoy molecule". As shown here, we have clarified the crystal structure of the decoy-molecule-bound form and elucidated that the location of its carboxylate group is virtually the same as that of palmitic acid in the heme cavity, indicating that the carboxylate group of the decoy molecule serves as the general acid-base catalyst. This result further confirms that the role of the acid-base function is satisfied by the carboxylate group of the substrates. In addition, the structure analysis of the substrate-free form has clarified that no remarkable structural change is induced by the binding of the decoy molecule as well as fatty acid. Consequently, whether the carboxylate group is positioned in the active site provides the switching mechanism of the catalytic cycle of cytochrome P450(BSβ).

  51. Aromatic C-H bond hydroxylation by P450 peroxygenases: a facile colorimetric assay for monooxygenation activities of enzymes based on Russig's blue formation Reviewed

    Osami Shoji, Christian Wiese, Takashi Fujishiro, Chikako Shirataki, Bernhard Wünsch, Yoshihito Watanabe

    J. Biol. Inorg. Chem.   Vol. 15 ( 7 ) page: 1109-1115   2010.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Aromatic C-H bond hydroxylation of 1-methoxynaphthalene was efficiently catalyzed by the substrate misrecognition system of the hydrogen peroxide dependent cytochrome P450BSβ (CYP152A1), which usually catalyzes hydroxylation of long-alkyl-chain fatty acids. Very importantly, the hydroxylation of 1-methoxynaphthalene can be monitored by a color change since the formation of 4-methoxy-1-naphthol was immediately followed by its further oxidation to yield Russig's blue. Russig's blue formation allows us to estimate the peroxygenation activity of enzymes without the use of high performance liquid chromatography, gas chromatography, and nuclear magnetic resonance measurements.

  52. Hydrogen Peroxide-Dependent Monooxygenations by Tricking the Substrate Recognition of Cytochrome P450BSb Reviewed

    Osami Shoji, Takashi Fujishiro, Hiroshi Nakajima, Misa Kim, Shingo Nagano, Yoshitsugu Shiro, Yoshihito Watanabe

    Angew. Chem. Int. Ed.   Vol. 46 ( 20 ) page: 3656-3659   2007.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  53. Supramolecular array of imizazolylethynyl-zinc-porphyrin Reviewed

    Akiharu Satake, Osami Shoji, Yoshiaki Kobuke

    J. Organomet. Chem.   Vol. 692 ( 1-3 ) page: 635-644   2006.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  54. Single Molecule Visualization of Coordination Assembled Porphyrin Macrocycles Reinforced with Covalent Linkings Reviewed

    Osami Shoji, Hiroyuki Tanaka, Tomoji Kawai, Yoshiaki Kobuke

    J. Am. Chem. Soc   Vol. 127 ( 24 ) page: 8598 -8599   2005.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  55. Coordination Assembled Rings of Ferrocene-Bridged Trisporphyrin with Flexible Hinge-like Motion: Selective Dimer Ring Formation, its Transformation to Larger Rings, and Vice Versa Reviewed

    Osami Shoji, Saori Okada, Akiharu Satake, Yoshiaki Kobuke

    J. Am. Chem. Soc   Vol. 127 ( 7 ) page: 2201-2210   2005.2

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  56. Temperature Dependence of Circular Dichroism and Fluorescence Decay of Pyrene Appended to the Side Chains of Poly-L-glutamine Reviewed

    Osami Shoji, Daisuke Nakajima, Masahiro Ohkawa, Yoshiki Fujiwara, Masahiko Annaka, Masako Yoshikuni, and Takayuki Nakahira

    Macromolecules   Vol. 36 ( 12 ) page: 4557-4566   2003.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  57. Side-chain Chromophore Orientation and Excitation Energy Transport in Films Prepared from Poly[N5-(R)- and N5-(S)-1-(1-naphthyl)ethyl-L-glutamines] Reviewed

    Osami Shoji, Yachiyo Higashi, Sachie Hishinuma, Masaki Sato, Masahiko Annaka, Masako Yoshikuni, and Takayuki Nakahira

    Macromolecules   Vol. 35 ( 6 ) page: 2116-2121   2002.2

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  58. Highly controlled side-chain chromophore orientation in poly[N5-1-(1-pyrenyl)ethyl--glutamines] Reviewed

    Osami Shoji, Daisuke Nakajima, Masahiko Annaka, Masako Yoshikuni, Takayuki Nakahira

    Polymer   Vol. 43 ( 5 ) page: 1711-1714   2001.11

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Poly[N5-(R and S)-1-(1-pyrenyl)ethyl-Image -glutamines] (1 and 2) were prepared by condensation of poly(Image -glutamic acid) with optically resolved amines. In solution, these polymers, 2 in particular, gave large circular dichroism (CD) indicative of exciton coupling among the side-chain pyrene chromophores. When compared with the corresponding polymer with achiral side groups, i.e. poly(1-pyrenylmethyl-Image -glutamine) (3), 1 and 2 not only gave much stronger CD, but also gave much reduced excimer emission with a significant hypsochromic shift of emission maximum. The highly controlled orientation of the side-chain chromophores is apparently brought about by the specific steric interactions among the bulky chiral side chains along the helical main chain.

  59. Secondary Structure and Side-Chain Chromophore Orientation in Poly(L-glutamines) Having Pyrene Chromophores in the Side Chains Reviewed

    Osami Shoji, Masataka Okumura, Hiromi Kuwata, Takuma Sumida, Ryo Kato, Masahiko Annaka, Masako Yoshikuni, and Takayuki Nakahira

    Macromolecules   Vol. 34 ( 12 ) page: 4270-4276   2001.5

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Books 17

  1. 酵素機能を化学的にハックする新規手法の開発、触媒年鑑:触媒技術の動向と展望 2021年版

    大村慧太, 愛場 雄一郎, 有安 真也, 荘司 長三( Role: Joint author)

    一般社団法人触媒学会  2021 

     More details

    Language:Japanese

  2. ペプチド核酸と相分離, 相分離生物学の全貌, 現代化学 増刊

    愛場 雄一郎, 荘司 長三( Role: Sole author)

    現代化学  2020 

     More details

    Language:Japanese

  3. 人工金属タンパク質で緑膿菌を狙い撃ち 緑膿菌が分泌するヘムタンパク質で金属フタロシアニンを送り込む

    荘司長三、四坂勇磨( Role: Joint author)

    ファルマシア(日本薬学会会報誌)  2020 

     More details

    Language:Japanese

  4. 感染症「鉄の取り込みを阻害する新しい抗菌薬の開発」

    四坂勇磨、荘司長三( Role: Joint author)

    アステラス製薬株式会社  2018.9 

     More details

    Language:Japanese

  5. 化学と生物「擬似基質による酵素活性化と高難度酸化反応」

    荘司長三( Role: Joint author)

    公益社団法人日本農芸化学会  2018.8 

     More details

    Language:Japanese

  6. 石油学会ペトロテック「酸化酵素の誤作動を利用するバイオ触媒開発」

    荘司長三( Role: Sole author)

    公益社団法人石油学会  2018.5 

     More details

    Language:Japanese

  7. 金属酵素による酸化反応と反応機構

    荘司長三( Role: Sole author)

    ㈱化学同人 『活性酸素・フリーラジカルの科学』日本化学会編  2016.3 

     More details

    Language:Japanese

  8. 緑膿菌の増殖を阻害する「人工金属タンパク質」

    荘司長三( Role: Sole author)

    公益社団法人日本化学会「化学と工業」  2015.2 

     More details

    Language:Japanese

  9. Monooxygenation of Small Hydrocarbons Catalyzed by Bacterial Cytochrome P450s

    Osami Shoji, Yoshihito Watanabe( Role: Joint author)

    Springer  2015  ( ISBN:978-3-319-16008-5

     More details

    Language:English

  10. 「頑固な酵素」を巧みに騙す

    荘司長三、渡辺芳人( Role: Joint author)

    生物工学会誌  2014.8 

     More details

    Language:Japanese

  11. Oxygenation of Nonnative Substrates Using a Malfunction State of Cytochrome P450s

    O. Shoji, Y. Watanabe( Role: Joint author)

    Springer  2014.5 

     More details

    Language:English

  12. 化学掲示板 新聞に載った注目記事(2月) 2月5日 日本経済新聞 院内感染の原因菌, 緑膿菌の増殖を抑える技術を開発

    荘司長三、白瀧千夏子( Role: Joint author)

    株式会社 化学同人 月刊「化学」  2014.3 

     More details

    Language:Japanese

  13. ベンゼンをフェノールに一段階で変換する新規バイオ触媒の開発

    荘司長三、渡辺芳人( Role: Joint author)

    日本工業出版株式会社「配管技術」  2013.12 

     More details

    Language:Japanese

  14. 酵素の基質誤認識を利用する不活性炭化水素の水酸化

    荘司長三( Role: Sole author)

    公益社団法人日本化学会「化学と工業」  2013.9 

     More details

    Language:Japanese

  15. 酵素を“誤作動”させて行う有機合成―― 酵素反応を有機化学に利用するための反応制御

    荘司長三、渡辺芳人( Role: Joint author)

    株式会社 化学同人 月刊「化学」  2013.8 

     More details

    Language:Japanese

  16. P450による酸素活性化機構と基質の酸素化機構 "P450の分子生物学 第2版"

    渡辺芳人、荘司長三( Role: Joint author)

    株式会社 講談社サイエンティフィック  2009.8 

     More details

    Language:Japanese

    注目の最新シトクロムP450の基礎と応用
    解毒作用の主役P450の最新構造解析や、急発展した医学分野での研究を踏まえた改訂版。薬物代謝分野はもちろん、動植物、微生物などでの多彩な働きを紹介

  17. 酵素工学ニュース「ヘム酵素の創成」

    渡辺芳人、荘司長三( Role: Joint author)

    酵素工学研究会誌  2009 

     More details

    Language:Japanese

▼display all

Presentations 124

  1. 金属酵素の誤作動誘起と高難度酸化反応 Invited

    荘司長三

    第53回酸化反応討論会 

     More details

    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン   Country:Japan  

  2. 緑膿菌の鉄獲得系を利用する選択的な光増感剤輸送と光殺菌 Invited

    荘司長三

    第94回日本感染症学会総会・学術講演会 

     More details

    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン   Country:Japan  

  3. Hydroxylation of nonnative substrates catalyzed by cytochrome P450BM3 exploiting decoy molecules International conference

    O. Shoji

    The 3rd IRCCS - The 2nd Reaction Infography Joint International Symposium: “Reaction Imaging Meets Materials Science" 

     More details

    Event date: 2020.1 - 2020.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Nagoya University   Country:Japan  

  4. 酵素を欺く化学分子は役に立つか

    荘司長三

    第6回名古屋大学の卓越・先端・次世代研究シンポジウム「専門性と学際性の狭間で」 

     More details

    Event date: 2020.1

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  5. Material Transformation Using Biocatalysts Assisted by External Additives International conference

    O. Shoji

    4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding 

     More details

    Event date: 2019.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Nara, Japan   Country:Japan  

  6. Hydroxylation of Nonnative Substrates Catalyzed by Cytochrome P450BM3 Exploiting Decoy Molecules International conference

    Osami Shoji

    2019 Korea-Taiwan-Japan Bioinorganic Chemistry Symposium 

     More details

    Event date: 2019.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Taichung City, Taiwan   Country:Taiwan, Province of China  

  7. HYDROXYLATION OF NONNATIVE SUBSTRATES BY CYTOCHROME P450BM3 EXPLOITING DECOY MOLECULES Invited International conference

    Osami Shoji

    12th China Japan Joint Symposium on Metal Cluster Compounds (CJJSMCC2019) 

     More details

    Event date: 2019.10

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Taichung City, Taiwan   Country:China  

  8. "Hydroxylation of Nonnative Substrates by Cytochrome P450BM3 Exploiting Decoy Molecules

    O.Shoji

     More details

    Event date: 2019.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  9. Use of Decoy Molecules to Trick Cytochrome P450s

    O.Shoji

     More details

    Event date: 2019.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  10. Hydroxylation of Nonnative Substrates by Cytochrome P450BM3 Exploiting Decoy Molecules International conference

    Osami Shoji

    19th International Conference on Biological Inorganic Chemistry (ICBIC-19) 

     More details

    Event date: 2019.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue: Interlaken   Country:Switzerland  

  11. Whole-Cell Biotransformation Catalysed by Intracellular Cytochrome P450BM3 Activated by Decoy Molecules Invited International conference

    Osami Shoji

    ArtZymes 2.0 

     More details

    Event date: 2019.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Basel   Country:Switzerland  

  12. 酵素の誤作動を誘起する分子の開発と物質変換 Invited

    荘司長三

    日本化学会東北支部山形地区講演会—生体外で活躍するタンパク質— 

     More details

    Event date: 2019.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:山形市   Country:Japan  

  13. シトクロムP450の基質誤認識を利用する菌体内物質変換 Invited

    荘司長三

    第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会 

     More details

    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:兵庫   Country:Japan  

  14. Use of Decoy Molecules to Trick Cytochrome P450BM3 into Hydroxylating Nonnative Substrates International conference

    Osami Shoji

    the 21st International Conference on Cytochrome P450 

     More details

    Event date: 2019.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Brisbane   Country:Australia  

  15. Hydroxylation of Nonnative Substrates Catalyzed by Cytochrome P450BM3 Assisted by Decoy Molecules Invited International conference

    Osami Shoji

    15th International Symposium on Applied Bioinorganic Chemistry (ISABC15) 

     More details

    Event date: 2019.6

    Language:English   Presentation type:Oral presentation (keynote)  

    Venue:Nara   Country:Japan  

  16. Cheating Cytochrome P450BM3 into Hydroxylating Non-Native Substrates by Exploiting its Substrate Misrecognition Invited

    O. Shoji

    Let's leap! Challenges in Organic Chemistry 

     More details

    Event date: 2019.4

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  17. Hydroxylation of Nonnative Substrates Catalyzed by Cytochrome P450BM3 Facilitated by Decoy Molecules Invited

    Osami Shoji

    New Frontier in Protein Design & Engineering 

     More details

    Event date: 2019.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  18. 酸化酵素の誤作動を誘起する低分子化合物による基質特異性変換 Invited

    荘司長三

    日本におけるケミカルバイオロジーの新展開第189委員会 平成30年度 第4回定例会 

     More details

    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:大阪市   Country:Japan  

  19. 酸化酵素の誤作動を誘起する擬似基質を用いる物質変換 Invited

    荘司長三

    分子研研究会「錯体化学を基盤とした階層構造制御と機能発現」 

     More details

    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:愛知   Country:Japan  

  20. Hydroxylation of Non-native Substrates Catalyzed by Cytochrome P450BM3 Activated by External Additives Invited

    Osami Shoji

    Core-to-Core Symposium Elements Function for Transformative Catalysis and Materials 

     More details

    Event date: 2019.2

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  21. 金属蛋白質の対象誤認識を利用する機能改変 Invited

    荘司長三

    新学術領域研究「高難度物質変換反応の開発を指向した精密制御反応場の創出」第6回公開シンポジウム 

     More details

    Event date: 2019.1

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:京都   Country:Japan  

  22. Hydroxylation of Non-native Substrates Catalyzed by Cytochrome P450BM3 with Decoy Moleculues Invited International conference

    O.Shoji

    2nd China-Japan Joint Symposium on the Biosynthesis of Natural Products 

     More details

    Event date: 2019.1

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue: Guangzhou, China   Country:China  

  23. 金属酵素の誤作動を利用する物質変換 Invited

    荘司長三

    新学術「生合成リデザイン」第5回公開シンポジウム 

     More details

    Event date: 2018.12

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:千葉   Country:Japan  

  24. Hydroxylation of Nonnative Substrates Catalyzed by Wild-type Cytochrome P450BM3 with Decoy Molecules Invited International conference

    O.Shoji

    The 13th International Symposium on Organic Reactions 

     More details

    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Hsinchu, Taiwan   Country:Taiwan, Province of China  

  25. 酸化酵素の誤作動を利用する物質変換 Invited

    荘司長三

    酵素工学研究会第80回講演会 

     More details

    Event date: 2018.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  26. ベンゼンをフェノールに変換するバイオ触媒系の開発

    荘司長三

    第49回中部化学関係学協会支部連合秋季大会 

     More details

    Event date: 2018.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:名古屋   Country:Japan  

  27. Hydroxylation of Non-native Substrates Catalyzed by Cytochrome P450BM3 Facilitated by Decoy Moleculues International conference

    O.Shoji

    FHI-JST Joint Symposium,Current Topics and Challenges for Innovative Catalysts 

     More details

    Event date: 2018.10 - 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Berlin, Germany   Country:Germany  

  28. 擬似基質を用いる基質特異性変換

    荘司長三

    第12回バイオ関連化学シンポジウム 

     More details

    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  29. 偽物の基質による酵素の誤作動を利用する物質変換 Invited

    荘司長三

    新化学技術推進協会(JACI)主催講演会 

     More details

    Event date: 2018.8

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  30. Heme Acquisition Protein HasA with Synthetic Metal Complexes as an Artificial Prosthetic Group

    O.Shoji

    The 68th Conference of Japan Society of Coordination Chemistry 

     More details

    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  31. Heme Acquisition Protein HasA with Metal-Phthalocyanine and 5,15-DiphenylporphyrinDerivatives as an Artificial Prosthetic Group International conference

    O.Shoji

    Tenth International Conference on Porphyrins and Phthalocyanines (ICPP-10) 

     More details

    Event date: 2018.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Munich, Germany   Country:Germany  

  32. 生体触媒の基質誤認識を利用する高難度水酸化反応 Invited

    荘司長三

    東京大学大学院薬学系研究科天然物化学教室セミナー 

     More details

    Event date: 2018.5

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  33. Hydroxylation of Nonnative Substrates Catalyzed by Cytochrome P450BM3 Assisted by Decoy Molecules Invited International conference

    O. Shoji

    3rd Japan - UK Joint Symposium on Coordination Chemistry 

     More details

    Event date: 2018.4 - 2018.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:St Andrews, UK.   Country:United Kingdom  

  34. Hydroxylation of gaseous alkanes and benzene catalyzed by cytochrome P450BM3 using decoy molecules as a substrate analogue International conference

    O. Shoji, Y. Watanabe

    255thACS National Meeting & Exposition 

     More details

    Event date: 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:New Orleans, USA   Country:United States  

  35. 疑似基質による酸化酵素の誤作動誘起と高難度水酸化反応

    荘司長三、小野田浩宜、元川竜平、中川洋、渡辺芳人

    第7回名古屋大学シンクロトロン光研究センターシンポジウム 

     More details

    Event date: 2018.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  36. 疑似基質による酸化酵素の高活性化と不活性アルカン類の水酸化

    荘司長三、有安真也、鈴木和人、中村大、唐澤昌之、愛場雄一、渡辺芳人

    第50回酸化反応討論会 

     More details

    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  37. 疑似基質による酵素活性化とメタン水酸化

    荘司 長三

    50周年記念プレシンポジウム~CREST・さきがけ「革新的触媒」メタン資源利用に向けて~ 

     More details

    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  38. Hydroxylation of Nonnative Substrate Catalyzed by Cytochrome P450BM3 using Decoy Molecules

    O. Shoji

    11th Japan-China Joint Symposium on Metal Cluster Compounds 

     More details

    Event date: 2017.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  39. Nonnative Substrate Hydroxylation Catalyzed by Cytochrome P450BM3 without any Mutagenesis

    O. Shoji

    The 2nd Japan-US Bilateral Meeting on Coordination Chemistry  

     More details

    Event date: 2017.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  40. 疑似基質による生体触媒の誤作動誘起と高難度酸化反応

    荘司 長三

    第57回オーロラセミナー 

     More details

    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  41. ヘム獲得蛋白質と合成金属錯体の複合体による緑膿菌の増殖抑制

    荘司 長三

    第27回金属の関与する生体関連反応シンポジウム(SRM2017) 

     More details

    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  42. Gaseous alkane and Benzene Hydroxylation Catalyzed by Cytochrome P450BM3 with the assistance of Decoy Molecules International conference

    O. Shoji

     More details

    Event date: 2017.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Viet Nam  

  43. フッ素含有疑似基質による酸化酵素の誤作動誘起と高難度酸化反応

    荘司 長三

    第14回フッ素相模セミナー 

     More details

    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  44. Development of Biocatalysts for Extremely Difficult Oxidation Reactions

    O. Shoji

     More details

    Event date: 2017.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  45. 生体触媒の誤作動を利用するガス状アルカンの触媒的変換反応

    荘司 長三

    日本化学会 第97春季年会 (2017) 

     More details

    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  46. Gaseous Alkane Hydroxylation Catalyzed by Cytochrome P450BM3 Assisted by Next Generation Decoy Molecules International conference

    O. Shoji

    SABIC-2017 

     More details

    Event date: 2017.1

    Language:English   Presentation type:Oral presentation (keynote)  

    Country:India  

  47. 酸化酵素の誤作動を利用するバイオ触媒系の創成

    荘司 長三

    JXエネルギー株式会社講演会 

     More details

    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  48. 酵素の誤作動を誘起する偽の基質と高難度酸化反応

    荘司 長三

    第8回 岩澤コンファレンス「サステイナブル社会のための最先端触媒化学・表面科学」 

     More details

    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  49. Growth Inhibition of Pseudomonas Aeruginosa by Hasa with Synthetic Metal Complexes and A Novel Elimination System of Bacteria by Photo-Irradiation International conference

    O. Shoji, C. Shirataki, Y. Shisaka, H. Uehara, Y. Iwai, A. Nakashima, M. Terada, S. Ozaki, H. Sugimoto, Y. Shiro, Y. Watanabe

    AsBIC8 

     More details

    Event date: 2016.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:New Zealand  

  50. フッ素置換疑似基質による生体触媒の反応制御

    荘司 長三

    フルオラス科学研究会第9回シンポジウム 

     More details

    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  51. 酵素の誤作動を利用する高難度物質変換

    荘司 長三

    東京理科大学講演会 

     More details

    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  52. Non-native Substrate Hydroxylation catalyzed by Cytochrome P450s Utilizing False Recognition of Target Substrates

    O. Shoji

    Japan-Korea-Taiwan Bioinorganic Chemistry Symposium  

     More details

    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  53. Construction of Biocatalysts Based on Substrate Misrecognition of Enzymes

    O. Shoji

     More details

    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  54. Hydroxylation of Non-Native Substrates by Tricking the Substrate Recognition of Cytochrome P450s International conference

    O. Shoji

    Japan-Australia Joint Symposium on Coordination Chemistry (JAJSCC2016)  

     More details

    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  55. Gaseous Alkane Hydroxylation by Cytochrome P450s Assisted by Decoy Molecules International conference

    O. Shoji

    SeleCa Workshop on Artificial Metalloenzymes 

     More details

    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Germany  

  56. Gaseous alkane hydroxylation by tricking the substrate recognition of cytochrome P450s International conference

    O. Shoji

    FOR 1405 Symposium with external guests at the RWTH Aachen University 

     More details

    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Germany  

  57. 疑似基質による生体触媒の誤作動と高難度酸化反応

    荘司 長三、叢 志奇、柳澤颯太、杉本 宏、城 宜嗣、渡辺 芳人

    第26回バイオ・高分子シンポジウム 

     More details

    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  58. 疑似基質による生体触媒の反応制御

    荘司長三

    第1回産総研中国センター酵素研究セミナー 

     More details

    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  59. 疑似基質による反応空間制御とガス状アルカンの水酸化反応

    荘司長三

    第16回日本蛋白質科学会年会 

     More details

    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  60. 外部添加因子による生体触媒の反応空間制御

    荘司長三

    分子研研究会「金属錯体の非対称配位圏設計と異方集積化が拓く新物質創成科学」 

     More details

    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  61. 生体触媒の基質誤認識を利用する不活性炭化水素へ酸素原子挿入反応触媒系の開発

    荘司長三

    新学術領域研究「精密制御反応場」第1回公開シンポジウム 

     More details

    Event date: 2016.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  62. Activation of cytochrome P450BM3 by decoy molecules for gaseous alkane hydroxylation International conference

    O. Shoji, Y. Watanabe

    Pacifichem 2015 

     More details

    Event date: 2015.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:United States  

  63. 次世代疑似基質によるシトクロムP450BM3の活性化とガス状アルカンの水酸化

    荘司長三、叢 志奇、杉本 宏、城 宜嗣、渡辺芳人

    第48回酸化反応討論会 

     More details

    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  64. 野生型シトクロムP450BM3によるガス状アルカンの水酸化反応を可能とする次世代疑似基質

    荘司長三、叢 志奇、笠井千枝、杉本 宏、城 宜嗣、渡辺芳人

    第9回バイオ関連化学シンポジウム 

     More details

    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  65. Hydroxylation of Gaseous Alkanes Catalyzed By Cytochrome P450BM3 Triggered By Decoy Molecules International conference

    O. Shoji, Y. Watanabe

    BIOTRANS2015 

     More details

    Event date: 2015.7

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  66. Growth inhibition of Pseudomonas aeruginosa by HasA with metal-phthalocyanine and a novel elimination system of bacteria by photo-irradiation International conference

    O. Shoji, C. Shirataki, Y. Iwai, A. Nakashima, M. Terada, S. Ozaki, H. Sugimoto, Y. Shiro, Y. Watanabe

    ICBIC17 

     More details

    Event date: 2015.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:China  

  67. Non-native substrate hydroxylation catalyzed by cytochrome P450BM3 triggered by decoy molecules International conference

    O. Shoji, Z. Cong, H. Sugimoto, Y. Shiro, Y. Watanabe

    "Metals in Biology" in Wako 

     More details

    Event date: 2015.6

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  68. Hydroxylation of non-native substrates catalyzed by wild-type P450s assisted by decoy molecules International conference

    O. Shoji

    19th International Conference on Cytochrome P450 

     More details

    Event date: 2015.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  69. 緑膿菌の鉄獲得機構を逆手に取った新規殺菌法の開発

    荘司長三

    第63回日本化学療法学会総会 

     More details

    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  70. Use of Decoy Molecules as a Reaction Accelerator for the Hydroxylation of Gaseous Alkanes Catalyzed by Cytochrome P450s

    O. Shoji

     More details

    Event date: 2015.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  71. 偽のヘム鉄獲得蛋白質を利用する緑膿菌の増殖阻害

    荘司長三

    第49回緑膿菌感染症研究会 

     More details

    Event date: 2015.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  72. 酸化酵素の誤作動を誘起する次世代疑似基質の開発とガス状アルカンの水酸化

    荘司長三

    分子研研究会「生物無機化学の最先端と今後の展望:金属と生体分子の作用機序解明とモデル化および応用への展開」 

     More details

    Event date: 2015.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  73. Hydroxylation of non-native substrates by wild-type cytochrome P450s assisted by decoy molecules International conference

    O. Shoji, Y. Watanabe

    the Active Enzyme Molecule 2014 

     More details

    Event date: 2014.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  74. 疑似基質による野生型シトクロムP450の誤作動誘起と不活性炭化水素の水酸化反応

    荘司長三、渡辺芳人

    第44回石油・石油化学討論会 

     More details

    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  75. Monooxygenation of Nonnative Substrates Catalyzed by Wild-type Cytochrome P450s International conference

    O. Shoji, Y. Watanabe

    The 12th International Symposium on Cytochrome P450 Biodiversity and Biotechnology 

     More details

    Event date: 2014.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  76. 改変鉄獲得タンパク質による緑膿菌の増殖阻害

    荘司長三、白瀧千夏子、岩井佑介、中島彩夏、寺田光良、小崎紳一、杉本 宏、城 宜嗣、渡辺芳人

    錯体化学会第64回討論会 

     More details

    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  77. 疑似基質による野生型酵素の誤作動誘起と不活性炭化水素の水酸化反応

    荘司長三、渡辺芳人

    第10回触媒化学融合研究センター講演会 

     More details

    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  78. Gaseous Alkane Hydroxylation by Wild-Type Cytochrome P450BM3 bearing Decoy Molecules International conference

    O. Shoji, J. Yokobori, T. Kunimatsu, N. Kawakami, Zhiqi Cong, Y. Watanabe

    ICPP-8 

     More details

    Event date: 2014.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Turkey  

  79. フッ素置換基質による生体触媒の誤作動誘起と物質変換への利用

    荘司長三、渡辺芳人

    2014年研究会「金属新機能場の開発を目指して」 

     More details

    Event date: 2014.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  80. 生体触媒の誤作動状態を逆手に取る物質変換

    荘司長三、渡辺芳人

    新学術領域研究「分子活性化」第6回公開シンポジウムプログラム 

     More details

    Event date: 2014.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  81. 生体触媒の誤作動状態を利用する物質変換

    荘司長三、渡辺芳人

    蛋白研セミナー:蛋白質の機能デザインに向けた実験と理論のインタープレー 

     More details

    Event date: 2014.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  82. Gaseous Alkanes and Benzene Hydroxylation by Wild-type Cytochrome P450BM3 Induced by Perfluorinated Carboxylic Acids

    The 3rd International Conference on the MEXT Project of Integrated Research on Chemical Synthesis  

     More details

    Event date: 2014.1

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  83. Gaseous Alkane Hydroxylation Catalyzed by Cytochrome P450BM3 by Tricking Its Substrate Recognition Using Decoy Molecules

    6th Japan-Korea Seminars on Biomolecular Science : Experiments and Simulation 

     More details

    Event date: 2013.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  84. Hydroxylation of Inert Organic Molecules by Cytochrome P450s Assisted by Decoy Molecules

    The 2nd Japan-France Coordination Chemistry Symposium 

     More details

    Event date: 2013.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  85. Hydroxylation of Non-native Substrates by Wild-type Cytochrome P450BM3 assisted by Decoy Molecules

     More details

    Event date: 2013.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  86. 疑似基質により誘起される生体触媒の誤作動状態を利用するバイオ触媒反応

    荘司長三、渡辺芳人

    第6回 ChemBioハイブリッドレクチャー 

     More details

    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  87. フッ素置換基質を疑似基質として利用する長鎖脂肪酸水酸化酵素よるガス状アルカンの水酸化反応

    荘司長三、川上了史、渡辺芳人

    錯体化学会第63回討論会 

     More details

    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  88. 野生型シトクロムP450BM3によるベンゼン及び一置換ベンゼンの水酸化

    荘司長三、國松辰弥、川上了史、渡辺芳人

    第6回バイオ関連化学シンポジウム 

     More details

    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  89. Ethane and Benzene Hydroxylation by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules International conference

    O. Shoji, T. Kunimatsu, N. Kawakami, Y. Watanabe

    , 16th International Conference on Biological Inorganic Chemistry (ICBIC16) 

     More details

    Event date: 2013.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:France  

  90. Gaseous Alkanes and Benzene Hydroxylation by Wild-Type Cytochrome P450BM3 Assisted by Decoy Modules International conference

    O. Shoji, N. Kawakami, T. Kunimatsu, Y. Watanabe

    The 18th International Conference on Cytochrome P450 

     More details

    Event date: 2013.6

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  91. シトクロムP450BM3の誤作動を逆手に取るアルカン類の水酸化反応

    荘司長三、川上了史、國松辰弥、渡辺芳人

    平成25年度 P450とUGT/SULT 研究会 

     More details

    Event date: 2013.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  92. Use of Enzyme Malfunction for Small Alkane Hydroxylation International conference

    O. Shoji, Y. Watanabe

    The 15th joint IRTG SYMPOSIUM between University of Münster - Nagoya University 

     More details

    Event date: 2013.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  93. 酵素の誤認識を利用するバイオ触媒の開発

    荘司長三

    若い世代の特別講演会 日本化学会第93春季年会(2013) 

     More details

    Event date: 2013.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  94. 有機化学利用をめざした生体触媒の反応制御

    荘司長三

    特別企画講演 日本化学会第93春季年会(2013) 

     More details

    Event date: 2013.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  95. 蛋白質の誤作動を利用する触媒システム開発と新規機能への展開

    荘司長三

    分子研研究会「生体配位化学の最前線と展望」 

     More details

    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  96. Development of Biocatalysts based on Substrate Misrecognition of Cytochrome P450s International conference

    O. Shoji, Y. Watanabe

    50th Anniversary Symposium on Cytochrome P450 in Fukuoka 

     More details

    Event date: 2012.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  97. 不斉炭素を持つ基質類似分子による酸化酵素のエナンチオ選択性制御

    荘司長三

    第45回 酸化反応討論会 

     More details

    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  98. 酸化酵素の誤作動を逆手に取ったバイオ触媒系の開発

    荘司長三

    第25回 生物無機化学夏季セミナー 

     More details

    Event date: 2012.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  99. Gaseous Alkane Hydroxylation Catalyzed by Cytochrome P450BM3 by Tricking its Substrate Recognition Using Decoy Molecules International conference

    O. Shoji, Y. Watanabe

    Seventh International Conference on Porphyrins and Phthalocyanines (ICPP-7) 

     More details

    Event date: 2012.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Korea, Republic of  

  100. 長鎖脂肪酸水酸化酵素の基質誤認識誘導によるガス状アルカンの水酸化反応

    荘司長三

    日本化学会第92春季年会(2012) 

     More details

    Event date: 2012.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  101. 疑似基質による酸化酵素の誤作動とガス状アルカンの水酸化反応

    荘司長三

    平成23年度 高難度選択酸化反応研究会シンポジウム 

     More details

    Event date: 2012.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  102. 水分子の排除をトリガーとするシトクロムP450の水酸化反応と疑似基質による基質多様性付加

    荘司長三

    中性子産業利用促進協議会  生体構造研究会 

     More details

    Event date: 2011.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  103. 自己完結型過酸化水素駆動シトクロムP450による一酸素原子添加反応

    荘司長三、藤城貴史、木本 洋、田中 翔太、堀 あゆ美、西尾 洸祐、杉本 洋、城 宜嗣、渡辺芳人

    第44回酸化反応討論会 

     More details

    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  104. 自己完結型過酸化水素駆動シトクロムP450の構築

    荘司 長三、藤城 貴史、木本 洋、杉本 宏、城 宜嗣、渡辺 芳人

    錯体化学会 第61回討論会 

     More details

    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  105. 細菌由来シトクロムP450 の基質誤認識を利用するバイオ触媒系の開発

    荘司 長三、川上了史、藤城 貴史、杉本 宏、永野 真吾、城 宜嗣、渡辺 芳人

    第5回バイオ関連化学シンポジウム 

     More details

    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  106. Hydroxylation of Gaseous Alkanes by Cytochrome P450 using Substrate Recognition Tricks International conference

    O. Shoji, T. Kunimatsu, N. Kawakami, Y. Watanabe

    ICBIC15 

     More details

    Event date: 2011.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  107. Crystal Structures of Hydrogen Peroxide-Dependent Cytochrome P450s Including Decoy Molecules and Oxidation Reaction of Non-natural Substrates International conference

    O. Shoji

    17th International Conference on Cytochrome P450 

     More details

    Event date: 2011.6

    Language:English   Presentation type:Oral presentation (general)  

  108. 基質認識トリックを利用する新規バイオ触媒系の開発

    荘司 長三

    統合物質創製化学推進事業 第2 回若手研究会 

     More details

    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  109. Construction of Biocatalysts using a Decoy Molecule of P450s

    Seminar at RWTH Aachen - Biotechnologie 

     More details

    Event date: 2010.12

    Language:English   Presentation type:Oral presentation (invited, special)  

  110. Gaseous Alkane Hydroxylation Catalyzed by Cytochrome P450 with Substrate Recognition Tricks International conference

    Seminar at Universitt Dortmund 

     More details

    Event date: 2010.12

    Language:English   Presentation type:Oral presentation (invited, special)  

  111. A novel approach to utilize cytochrome P450s as a biocatalyst International conference

    IRTG seminar 

     More details

    Event date: 2010.12

    Language:English   Presentation type:Oral presentation (invited, special)  

  112. シトクロムP450の基質認識トリックを利用するガス状アルカンの水酸化反応

    第1回統合物質シンポジウム 

     More details

    Event date: 2010.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  113. 細菌由来シトクロムP450による飽和炭化水素の水酸化反応

    荘司 長三、川上 了史、藤城 貴史、杉本 宏、永野 真吾、城 宜嗣、渡辺 芳人

    第60回錯体化学討論会 

     More details

    Event date: 2010.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  114. シトクロムP450のデコイ基質を利用する基質特異性変換

    荘司 長三、藤城 貴史、田中 翔太、川上 了史、杉本 宏、永野 真吾、城 宜嗣、渡辺 芳人

    第4回バイオ関連化学シンポジウム 

     More details

    Event date: 2010.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  115. シトクロムP450の基質特異性変換と反応制御

    荘司 長三、藤城 貴史、田中 翔太、杉本 宏、永野 真吾、城 宜嗣、渡辺 芳人

    第37回 生体分子科学討論会 

     More details

    Event date: 2010.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  116. 第42回 酸化反応討論会

    荘司長三、藤城貴史、田中翔太、永野真吾、城宜嗣、渡辺芳人

    シトクロムP450の基質特異性を変換する新規手法の開発 

     More details

    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  117. Monooxidations of Non-natural Substrates by Hydrogen Peroxide-Dependent Cytochrome P450: Tricking the Substrate Recognition of Cytochrome P450BSβ by Decoy Molecules International conference

    16 th International Conference on Cytochrome P450 (ICC2009) 

     More details

    Event date: 2009.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  118. Crystal Structures of the Substrate-Free and the Decoy Molecule-bound Forms of Cytochrome P450BSβ International conference

    14th International Conference on Biological Inorganic Chemistry (ICBIC14) 

     More details

    Event date: 2009.6

    Language:English  

  119. Creating Semi-Artificial Enzymes by Tricking the Substrate Recognition of Cytochrome P450BSβ International conference

    7th joint IRTG Symposium University of Münster and Nagoya University 

     More details

    Event date: 2009.5

    Language:English   Presentation type:Oral presentation (invited, special)  

  120. 過酸化水素駆動型シトクロムP450BSによる芳香環水酸化反応

    荘司長三、WIESE, Christian、藤城貴史・WÜNSCH, Bernhard、永野真吾、城宜嗣、渡辺芳人

    日本化学会第89春季年会 

     More details

    Event date: 2009.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  121. 酵素の基質誤認識を利用する過酸化水素駆動型バイオ触媒の開発

    荘司長三

    大学間連携事業第3回若手フォーラム 

     More details

    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  122. ヘム酵素反応空間の外部添加因子による修飾と反応制御

    荘司長三

    第39回中部化学関係学協会支部連合協議会秋季大会 

     More details

    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  123. 枯草菌由来の過酸化水素駆動型シトクロムP450による非天然基

    荘司長三、藤城貴史、中島洋、松永勇、永野真吾、城宜嗣、渡辺芳人

    第102回触媒討論会 

     More details

    Event date: 2008.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  124. デコイ分子により誘起されるシトクロムP450BSbの基質誤認識を利用する非天然基質の酸化反応

    荘司長三、藤城貴史、永野真吾、城宜嗣、渡辺芳人

    第3回バイオ関連化学合同シンポジウム2008 

     More details

    Event date: 2008.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 2

  1. 石油系原料からの高付加価値品製造に関する研究

    2016.6 - 2017.3

    企業からの受託研究 

    瀬川敦司、牧田智裕

  2. シトクロムP450による光駆動型酸化反応を可能にする金属錯体連結疑似基質の開発

    2015.4 - 2016.3

    企業からの受託研究 

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 外部添加因子による生体触媒反応場の制御と高難度物質変換

    2015.6 - 2020.3

    科学研究費補助金  新学術領域研究(研究領域提案型)

      More details

    Authorship:Principal investigator 

  2. 変性蛋白質の自己集合状態を利用する新規機能性蛋白質の開発

    2015.4 - 2016.3

    科学研究費補助金 

  3. 改変型鉄獲得蛋白質による緑膿菌の鉄獲得阻害と光線力学的反応を併用する殺菌システム

    2014.4 - 2018.3

    科学研究費補助金  若手研究(A)

  4. 生体触媒の基質誤認識を利用する不活性炭化水素への酸素原子挿入反応触媒系の開発

    2013.4 - 2015.3

    科学研究費補助金  新学術領域研究(研究領域提案型)

      More details

    Authorship:Principal investigator 

  5. 酵素の基質誤認識を利用するバイオ触媒の創成

    2009.4 - 2012.3

    科学研究費補助金  若手研究(A)

  6. 高難度酸化反応を可能とするヘム酵素の創

    2006.4 - 2009.3

    科学研究費補助金 

▼display all

Industrial property rights 6

  1. 高圧化学反応装置

    渡辺 芳人、荘司 長三

     More details

    Application no:特願2017-195706  Date applied:2017.10

    Country of applicant:Domestic  

  2. シトクロムP450モノオキシゲナーゼデコイ基質

    渡辺 芳人、荘司 長三

     More details

    Application no:特願2017-173446  Date applied:2017.9

    Country of applicant:Domestic  

  3. 炭化水素系基質の水酸化のための材料およびその利用

    渡辺 芳人、荘司 長三

     More details

    Application no:特願2015-201431  Date applied:2015.10

    Country of applicant:Domestic  

  4. 細菌の増殖抑制

    荘司長三、渡辺芳人、白瀧千夏子、岩井佑介

     More details

    Applicant:国立大学法人名古屋大学

    Application no:特願2014-061575  Date applied:2014.3

    Country of applicant:Domestic  

  5. ヘム蛋白質のヘム置換法

    渡辺芳人、荘司長三、川上了史

     More details

    Applicant:国立大学法人名古屋大学代表者 浜口 道成

    Application no:61/610,112  Date applied:2012.3

    Country of applicant:Foreign country  

  6. 不活性炭化水素の水酸化方法およびダミー分子

    荘司長三、川上了史、渡辺芳人

     More details

    Applicant:国立大学法人名古屋大学代表者 浜口 道成

    Application no:特願2010-164828  Date applied:2010.7

    Country of applicant:Domestic  

    本発明は、シトクロムP450モノオキシゲナーゼとダミー分子とを用いて不活性炭化水素を水酸化する方法、および、この水酸化方法に用いられるダミー分子に関する。

▼display all

 

Teaching Experience (On-campus) 4

  1. 化学講究

    2017

  2. 生物無機化学

    2017

  3. 無機・物化機器分析

    2017

  4. 基礎セミナー

    2016