Updated on 2023/09/29

写真a

 
HIRAKO Yoshiaki
 
Organization
Graduate School of Science Lecturer
Graduate School
Graduate School of Science
Undergraduate School
School of Science
Title
Lecturer
Contact information
メールアドレス

Degree 1

  1. 博士(理学) ( 1998.3   名古屋大学 ) 

Research Interests 1

  1. Cell adhesion, Cell to ECM adhesion, Cytoskeleton, Integrin, Collagen, Laminin, Intermediated filament, Bullous skin diseases, Hemidesmosome

Research Areas 2

  1. Others / Others  / Dermatology

  2. Others / Others  / Cell Biology

Current Research Project and SDGs 1

  1. 上皮組織における細胞接着の分子機構の解明

Research History 1

  1. Nagoya University   Graduate School of Science Division of Biological Science Biological Systems   Lecturer

    2004.4

Education 2

  1. Nagoya University   Graduate School of Science   Department of Molecular Biology

    1992.4 - 1998.3

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    Country: Japan

  2. Tohoku University   Faculty of Science   Department of Biology

    1988.4 - 1992.3

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    Country: Japan

Professional Memberships 3

  1. The Japanese Society for Investigative Dermatology

  2. Japan Society for Cell Biology

  3. 日本結合組織学会

Committee Memberships 1

  1. 日本研究皮膚科学会   評議員  

    2017.4   

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    Committee type:Academic society

 

Papers 30

  1. Anti-beta 4 integrin autoantibodies in patients with mucous membrane pemphigoid: A retrospective analysis from a tertiary centre in Italy Reviewed International coauthorship

    Maglie Roberto, De Almeida Carolina Vieira, Baffa Maria Efenesia, Bianchi Beatrice, Caproni Marzia, Di Zenzo Giovanni, Li Xiaoguang, Hirako Yoshiaki, Hashimoto Takashi, Tusa Ignazia, Lulli Matteo, Rovida Elisabetta, Antiga Emiliano

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   Vol. 37 ( 2 ) page: 249 - 251   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdv.18617

    Web of Science

  2. C-Terminal Processing of Collagen XVII Induces Neoepitopes for Linear IgA Dermatosis Autoantibodies Reviewed

    Toyonaga Ellen, Nishie Wataru, Izumi Kentaro, Natsuga Ken, Ujiie Hideyuki, Iwata Hiroaki, Yamagami Jun, Hirako Yoshiaki, Sawamura Daisuke, Fujimoto Wataru, Shimizu Hiroshi

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 137 ( 12 ) page: 2552-2559   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jid.2017.07.831

    Web of Science

  3. Loss of interaction between plectin and type XVII collagen results in epidermolysis bullosa simplex Reviewed

    Natsuga Ken, Nishie Wataru, Nishimura Machiko, Shinkuma Satoru, Watanabe Mika, Izumi Kentaro, Nakamura Hideki, Hirako Yoshiaki, Shimizu Hiroshi

    HUMAN MUTATION   Vol. 38 ( 12 ) page: 1666-1670   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/humu.23344

    Web of Science

  4. Unique mouse monoclonal antibodies reactive with maturation-related epitopes on type VII collagen Reviewed

    Hayakawa Taihei, Hirako Yoshiaki, Teye Kwesi, Tsuchisaka Atsunari, Koga Hiroshi, Ishii Norito, Karashima Tadashi, Kaneda Minori, Oyu Yuka, Tateishi Chiharu, Sugawara Koji, Yonamine Ayano, Shinkuma Satoru, Shimizu Hiroshi, Fukano Hideo, Shimozato Kazuo, Nguyen Ngon T., Marinkovich M. Peter, Tsuruta Daisuke, Hashimoto Takashi

    EXPERIMENTAL DERMATOLOGY   Vol. 26 ( 9 ) page: 811-819   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/exd.13306

    Web of Science

  5. β4 integrin in hereditary and acquired mucocutaneous diseases Invited Reviewed

    Hashimoto T, Hirako Y, Tsuruta D

    Exp Dermatol     2016.2

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    Language:English  

    DOI: 10.1111/exd.12961

  6. Integrin β4 is a major target antigen in pure ocular mucous membrane pemphigoid. Reviewed

    Li X, Qian H, Sogame R, Hirako Y, Tsuruta D, Ishii N, Koga H, Tsuchisaka A, Jin Z, Tsubota K, Fukumoto A, Sotozono C, Kinoshita S, Hashimoto T.

    Eur J Dermatol.   Vol. 26 ( 3 ) page: 247-253   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1684/ejd.2016.2772

    PubMed

  7. Linear IgA/IgG bullous dermatosis reacts with multiple laminins and integrins. Reviewed

    Li X, Tsuchisaka A, Qian H, Teye K, Ishii N, Sogame R, Harada K, Nakagomi D, Shimada S, Tateishi C, Hirako Y, Hashimoto T.

    Eur J Dermatol   Vol. 25 ( 5 ) page: 418-423   2015.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  8. A Case of Subepidermal Blistering Disease with Autoantibodies to Multiple Laminin Subunits who Developed Later Autoantibodies to Alpha-5 Chain of Type IV Collagen Associated with Membranous Glomerulonephropathy. Reviewed

    Sueki H, Sato Y, Ohtoshi S, Nakada T, Yoshimura A, Tateishi C, Borza DB, Fader W, Ghohestani RF, Hirako Y, Koga H, Ishii N, Tsuchisaka A, Qian H, Li X, Hashimoto T

    Acta Derm Venereol   Vol. 95 ( 7 ) page: 826-829   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2340/00015555-2059

  9. Pure ocular mucous membrane pemphigoid reactive with both integrin beta-4 and BP180 C-terminal domain. Reviewed

    Solano-López G, Concha-Garzón MJ, Sánchez-Pérez J, Hirako Y, Li X, Ishii N, Hashimoto T, Daudén E.

    Br J Dermatol.     2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/bjd.13290

  10. N-linked glycosylation on laminin γ1 influences recognition of anti-laminin γ1 pemphigoid autoantibodies. Reviewed

    Li X, Qian H, Takizawa M, Koga H, Tsuchisaka A, Ishii N, Hayakawa T, Ohara K, Sitaru C, Zillikens D, Sekiguchi K, Hirako Y, Hashimoto T.

    J Dermatol Sci   Vol. 77 ( 2 ) page: 125-129   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  11. A case of oral mucous membrane pemphigoid with IgG antibodies to integrin α6β4. Reviewed

    Miyamoto S, Chikazu D, Yasuda T, Enomoto A, Oh-I T, Hirako Y, Tsuchisaka A, Yasukochi A, Sogame R, Teye K, Koga H, Ishii N, Qian H, Li X, Hashimoto T.

    Br J Dermatol.     2014.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/bjd.13113

  12. A case of concurrent antilaminin γ1 pemphigoid and antilaminin-332-type mucous membrane pemphigoid. Reviewed

    Li X, Qian H, Ishii N, Yamaya M, Fukuda H, Mukai H, Hirako Y, Hashimoto T.

    Br J Dermatol     2014.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/bjd.13107

  13. Major cleavage-dependent epitopes for linear IgA bullous dermatosis are formed at the boundary between the non-collagenous 16A and collagenous 15 domains of BP180. Reviewed

    Yamauchi T, Matsushita S, Hashimoto T, Hirako Y.

    J Dermatol Sci.   Vol. 76 ( 1 ) page: 25-33   2014.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  14. Isolation of a hemidesmosome-rich fraction from a human squamous cell carcinoma cell line. Reviewed

    Hirako Y, Yonemoto Y, Yamauchi T, Nishizawa Y, Kawamoto Y, Owaribe K.

    Exp Cell Res.   Vol. 324 ( 2 ) page: 172-182   2014.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  15. 眼型粘膜類天疱瘡

    十亀良介、石井文人、古賀浩嗣、平子善章、橋本隆

    Visual Dermatology   Vol. 12 ( 2 ) page: 168-169   2013.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  16. Plectin deficiency leads to both muscular dystrophy and pyloric atresia in epidermolysis bullosa simplex. Reviewed

    Natsuga K, Nishie W, Shinkuma S, Arita K, Nakamura H, Ohyama M, Osaka H, Kambara T, Hirako Y, Shimizu H.

    Hum Mutat   Vol. 31 ( 10 ) page: 1687-1698   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  17. Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex. Reviewed

    Natsuga K, Nishie W, Akiyama M, Nakamura H, Shinkuma S, McMillan JR, Nagasaki A, Has C, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Sawamura D, Bruckner-Tuderman L, Shimizu H.

    Hum Mutat   Vol. 31 ( 3 ) page: 308-316   2010.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  18. IgG from patients with bullous pemphigoid depletes cultured keratinocytes of the 180-kDa bullous pemphigoid antigen (type XVII collagen) and weakens cell attachment. Reviewed

    Iwata H, Kamio N, Aoyama Y, Yamamoto Y, Hirako Y, Owaribe K, Kitajima Y.

    J Invest Dermatol   Vol. 129 ( 4 ) page: 919-926   2009.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  19. Cell adhesion and the cytoskeleton Invited

      Vol. 80 ( 3 ) page: 184-193   2008.3

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    Authorship:Lead author   Language:Japanese  

  20. Hepatic stellate cells express synemin, a protein bridging intermediate filaments to focal adhesions. Reviewed

    Uyama N, Zhao L, Van Rossen E, Hirako Y, Reynaert H, Adams DH, Xue Z, Li Z, Robson R, Pekny M, Geerts A.

    Gut   Vol. 55   page: 1276-1289   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  21. *Both type-I hemidesmosomes and adherens-type junctions contribute to the cell-substratum adhesion system in myoepithelial cells. Reviewed

    Uematsu J, Nishizawa Y, Hirako Y, Kitamura K, Usukura J, Miyata T, Owaribe K.

    Eur J Cell Biol   Vol. 84   page: 407-415   2005

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    Language:English   Publishing type:Research paper (scientific journal)  

  22. IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin alpha3 chain in a patient with an autoimmune subepidermal blistering disease. Reviewed

    Baican A, Hirako Y, Lazarova Z, Yancey KB, Zillikens D, Sitaru C.

    J Am Acad Dermatol   Vol. 53 ( 2 ) page: 517-522   2005

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    Language:English   Publishing type:Research paper (scientific journal)  

  23. Anti-p200 pemphigoid--a new bullous autoimmune dermatosis Invited Reviewed

    Shimanovich I, Rose C, Hirako Y, Butt-Dorje E, Zillikens D.

    J Dtsch Dermatol Ges   Vol. 2 ( 1 ) page: 7-14   2004

  24. *The 97-kDa (LABD97) and 120-kDa (LAD-1) fragments of bullous pemphigoid antigen 180/type XVII collagen have different N-termini. Reviewed

    Hirako Y, Nishizawa Y, Sitaru C, Opitz A, Marcus K, Meyer HE, Butt E, Owaribe K, Zillikens D.

    J Invest Dermatol   Vol. 121 ( 6 ) page: 1554-1556   2003

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  25. Extracellular cleavage of bullous pemphigoid antigen 180/type XVII collagen and its involvement in hemidesmosomal disassembly. Reviewed

    Hirako Y, Yoshino K, Zillikens D, Owaribe K.

    J Biochem   Vol. 133 ( 2 ) page: 197-206   2003

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  26. Characterization of mammalian synemin, an intermediate filament protein present in all four classes of muscle cells and some neuroglial cells: co-localization and interaction with type III intermediate filament proteins and keratins. Reviewed

    Hirako Y, Yamakawa H, Tsujimura Y, Nishizawa Y, Okumura M, Usukura J, Matsumoto H, Jackson KW, Owaribe K, Ohara O.

    Cell Tissue Res   Vol. 313 ( 2 ) page: 195-207   2003

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  27. Molecular architecture of hemidesmosomes and desmosomes. Invited

    Hirako Y, Owaribe K.

    Seikagaku   Vol. 71 ( 12 ) page: 1417-1431   1999

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    Authorship:Lead author   Language:Japanese  

  28. Hemidesmosomes and their unique transmembrane protein BP180. Invited Reviewed

    Hirako Y, Owaribe K.

    Microsc Res Tech   Vol. 43 ( 3 ) page: 207-217   1998

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    Authorship:Lead author   Language:English  

  29. *Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide. Reviewed

    Hirako Y, Usukura J, Uematsu J, Hashimoto T, Kitajima Y, Owaribe K.

    J Biol Chem   Vol. 273 ( 16 ) page: 9711-9717   1998

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  30. *Demonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formation. Reviewed

    Hirako Y, Usukura J, Nishizawa Y, Owaribe K.

    J Biol Chem   Vol. 271 ( 23 ) page: 13739-137345   1996

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

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Books 2

  1. 細胞外マトリックス実験法

    ( Role: Contributor ,  6.2.3. XVII型コラーゲン)

    丸善出版  2021.12  ( ISBN:978-4-621-30685-7

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    Total pages:454   Responsible for pages:221-228   Language:Japanese Book type:Scholarly book

  2. Recent Development in Cell Research; Hemidesmosomes and bullous pemphigoid antigens: ectodomain cleavage of BP180/type XVII collagen and novel spliced variants of BPAG1.

    Hirako Y, Okukmura M, Owaribe K:( Role: Joint author)

    Research Signpost  2003 

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    Language:English

Presentations 37

  1. 上皮シート構造を維持する中間径線維ネットワークにおけるインテグリンα 6 β 4- プレクチン結合の重要性

    平子善章、橋本航、浅倉亮佑

    第75回日本細胞生物学会大会  2023.6.28  日本細胞生物学会

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    Event date: 2023.6

    Language:English   Presentation type:Poster presentation  

    Venue:奈良県コンベンションセンター   Country:Japan  

  2. インテグリンβ 4 鎖セリン残基のアラニン置換によるヘミデスモソーム画分調製の効率化の検討

    久保田都、平子善章

    第75回日本細胞生物学会  2023.6.28  日本細胞生物学会

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    Event date: 2023.6

    Language:English   Presentation type:Poster presentation  

    Venue:奈良県コンベンションセンター   Country:Japan  

  3. Hemidesmosomes contribute to the mechanical strength of epithelial cell sheets adhering to the substrate

    2022.12.2 

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    Event date: 2022.12

    Language:English   Presentation type:Poster presentation  

  4. Hemidesmosomes contribute to the mechanical strength of epithelial cell sheets adhering to the substrate

    2022.6.28 

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    Event date: 2022.6

    Language:English   Presentation type:Poster presentation  

  5. Hemidesmosomes contribute to the mechanical strength of epithelial cell sheets adhering to the substrate

    Kou Hashimoto, Yoshiaki Hirako

    2021.6.26 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  6. XVII型コラーゲン欠失培養ラット表皮角化細胞株の作製とヘミデスモソーム形成への影響の解析

    藤岡光、平子善章

    第52回日本結合組織学会学術大会  2020.9.19 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン会議  

  7. 基底膜タンパク質ラミニン332の沈着パターン形成におけるプレクチンの機能の検証

    浅倉亮佑、平子善章

    第52回日本結合組織学会学術大会  2020.9.19 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン会議  

  8. Generation of cultured human cells deficient in dermal-epidermal adhesion apparatus by genome editing International conference

    Yoshiaki Hirako, Ryotaro Kamo and Tatsuya Hiraki.

    Japan - Singapore International Skin Conference 2019 

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    Event date: 2019.4

    Language:English   Presentation type:Poster presentation  

    Venue:Clinical Sciences Building, 11 Mandalay Rd, Singapore   Country:Singapore  

  9. Distinct roles of two plakin proteins in type I hemidesmosomes

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    Event date: 2017.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  10. ヘミデスモソーム構造における2種類のプラーキンタンパク質の役割の解析

    近藤擁, 加茂遼太郎, 平子善章

    第49回日本結合組織学会学術大会 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重県津市 三重県総合文化センター   Country:Japan  

  11. Knockout of type XVII collagen in DJM-1 cells affects structure of type I hemidesmosomes and deposition pattern of laminin-332 matrix

    The 27th CDB meeting "Body Surface Tactics" 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  12. XVII型コラーゲンを欠失したDJM-1細胞は、I型ヘミデスモソーム形成とラミニン332マトリックス沈着パターンに異常を示す

    山内友恵、加茂遼太郎、平子善章

    第68回日本細胞生物学会大会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都メルサ   Country:Japan  

  13. DJM-1 cells deficient in BP180/type XVII collagen exhibit rudiment hemidesmosomes and abnormal pattern of laminin-332 matrix

    Yoshiaki Hirako, Ryotaro Kamo , Minori Kaneda

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    Event date: 2015.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  14. DJM-1細胞を用いたヘミデスモソームの基礎研究 Invited

    平子善章

    第37回水疱症研究会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福島市三河南町1番20号 コラッセ福島   Country:Japan  

  15. Type XVII collagen plays an important role in the formation of type I hemidesmosomes and the laminin-332 matrix assembly

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  16. Major cleavage-dependent epitopes for linear IgA bullous dermatosis are formed at the boundary between the NC16A and C15 domains of BP180

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    Event date: 2014.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  17. A low calcium culture condition promotes deposition of laminin-332 and formation of hemidesmosomes in a squamous carcinoma cell line

    Yoshiaki Hirako, Yuki Yonemoto, Tomoe Yamauchi, Yuji Nishizawa, Yoshiyuki Kawamoto, Katsushi Owaribe

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    Event date: 2014.6

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  18. Ectodomain shedding of type XVII collagen induces formation of cleavage-dependent autoantigenic epitopes

    Tomoe Yamauchi, Satoshi Matsushita, Takashi Hashimoto, Yoshiaki Hirako

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    Event date: 2014.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  19. 基礎研究者の視点から見たヘミデスモソームと自己免疫性皮膚疾患 Invited

    平子善章

    第365回日本皮膚科学会福岡地方会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡県久留米市 久留米大学 筑水会館   Country:Japan  

  20. A muscle specific isoform of LMO7 localizes to costamere, a cell-substrate adhesion site in striated muscle

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    Event date: 2013.6

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  21. An epithelial isoform of LMO7 interacts with actin cytoskeleton through a novel functional region at its N-terminus International conference

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    Event date: 2012.5

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  22. Preparation of the hemidesmosome-rich fraction from a human squamous cell carcinoma line DJM-1

    Yoshiaki Hirako, Yuki Yonemoto, Katsushi Owaribe

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    Event date: 2011.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  23. Large scale study defined human β4 integrin as the major autoantigen for pure ocular mucous membrane pemphigoid

    Ryosuke Sogame, Yoshiaki Hirako, Daisuke Tsuruta, Norito Ishii, Teruki Dainichi, Hiroshi Koga, Shunpei Fukuda, Bungo Ohyama, Takahiro Hamada, Tadashi Karashima, Takekuni Nakama, Katsushi Owaribe, Kazuo Tsubota, Shigeru Kinoshita, Takashi Hashimoto

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    Event date: 2011.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. A monoclonal antibody and Linear IgA bullous dermatosis autoantibodies preferentially recognize epitopes within the NC16A domain of BP180 International conference

    Satoshi Matsushita, Takashi Hashimoto, Katsushi Owaribe, Yoshiaki Hirako

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    Event date: 2010.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  25. 単層上皮におけるヘミデスモソーム関連タンパク質の分布パターン

    富樫宏一、植松淳、尾張部克志、平子善章

    第42回日本結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  26. Cell to Extracellular Matrix Adhesion Structures in Stratified and Simple Epithelia Invited

    Yoshiaki Hirako

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    Event date: 2009.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  27. Localization of a cleavage-dependent epitope within the non-collagenous 16A domain of the 180 kDa bullous pemphigoid antigen

    Satoshi Matsushita, Katsushi Owaribe, Yoshiaki Hirako

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    Event date: 2009.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  28. Analyses of hemidesmosome-rich fraction prepared from a human squamous cell carcinoma line

    Yuki Yonemoto, Tomoya Katsura, Katsushi Owaribe, Yoshiaki Hirako

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    Event date: 2009.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  29. Calcium influences Hemidesmosome Formation and Processing of Laminin332

    Yoshiaki Hirako, Yuki Yonemoto, Tomoya Katsura, Katsushi Owaribe

    8th Pan-Pacific Connective Tissue Society Symposium 

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    Event date: 2009.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  30. Preparation of the hemidesmosome-rich fraction from a human squamous cell carcinoma cell line

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    Event date: 2008.6

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  31. Gastrointestinal distribution of the 180-kDa bullous pemphigoid antigen International conference

    Post IID 2008 satellite internaional meeting on autoimmne bullous diseases 

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    Event date: 2008.5

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  32. Plasminogen system mediates the C-terminal cleavage of the 120-kDa LAD-1 producing a 97-kDa polypeptide

    The 31st annual meeting of the Japanese society for investigative dermatology, Kyoto, 2006, 

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    Event date: 2006

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  33. Characerization of type XII collagen as an adhesive ligand for keratinocytes

    The 31st annual meeting of the Japanese society for investigative dermatology, Kyoto 

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    Event date: 2006

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  34. Identification of 350-kDa polypeptide of the isolated hemidesmosome fraction as type XII collagen

    The 58th annual meeting of Japan society for cell biology 

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    Event date: 2005

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  35. Serine protease inhibitors suppress the C-terminal cleavage of the soluble ectodomain of type XVII collagen. International conference

    Meeting of special priority program1086 -Genetic and molecular analysis of basement membranes and its anchorage-. Kloster Irsee, Germany 

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    Event date: 2004

    Language:English   Presentation type:Oral presentation (general)  

  36. Plasminogen system mediates the C-terminus cleavage of the 120-kDa soluble ectodomain of the type XVII collagen/BP180 resulting in the 97-kDa fragment.

    The 57th annual meeting of Japan society for cell biology, Osaka 

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    Event date: 2004

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  37. Single-molecule tracking/dragging revealed transient actin severing in the membrane skeleton as a mechanism for intercompartmental hot movement of membrane molecules

    Annual meeting of the biophysical society (U. S.), Baltimore, MD, USA 

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    Event date: 2004

    Language:English  

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. 自己免疫性皮膚疾患の自己抗原同定のための検査用キットの開発

    Grant number:AS231Z04402F  2011.8 - 2012.3

    科学技術振興機構研究成果最適展開支援事業 (A-STEP) 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1500000 ( Direct Cost: \1300000 、 Indirect Cost:\200000 )

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. Analyses of hemidesmosomal assembly and disassembly using cultured model cells of inherited blistering skin diseases.

    Grant number:17K10207  2017.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Hirako Yoshiaki

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    By genome editing, we established epidermis-derived cultured cell lines lacking each of the four major hemidesmosome constituents. Hemidesmosomes were rarely formed in cells lacking plectin or integrin β4 subunit. In type XVII collagen-deficient cells, type II hemidesmosome-like structures were observed, but type I hemidesmosomes were no longer formed. On the other hand, BP230-deficient cells formed type I hemidesmosome-like adhesions. It was suggested that the homotrimer-forming ability of type XVII collagen is important for the assembly of hemidesmosomal constituents into the type I structure.

  2. Elucidation of the mechanism of suppression of outer nulear layer cell death of retinitis pigmentosa model rat retina by rapamycin.

    Grant number:15K10883  2015.4 - 2018.3

    NISHIZAWA Yuji

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Competitive

    We successfully transiently suppressed visual photoreceptor death by microinjecting rapamycin to the eyeball of rhodopsin P347L transgenic rat (Tg rat), a retinal pigmentosa (RP) model rat. By rapamycin injection, mRNA expression levels of Bip and CHOP of the Tg rat retina were transiently and significantly decreased. On the other hand, mRNA expression level of Atg5 consistently increased significantly in Tg rats. Also, the fluorescence intensity of LC3 was greatly enhanced in visual cells after injection of rapamycin. From the above results, it was suggested that autophagy was transiently enhanced by injection of rapamycin into the Tg rat eyeball, and the ER stress response improved and apoptosis was delayed.

  3. 重層上皮のみに発現する新規の細胞・細胞間接着タンパク質ANKRD35の解析

    Grant number:26670527  2014.4 - 2017.3

    科学研究費補助金  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

  4. 180kDa類天疱瘡抗原の切断と自己抗原性獲得機構

    Grant number:23659547  2011.4 - 2014.3

    科学研究費補助金  挑戦的萌芽研究、課題番号:23659547

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

  5. ヒトヘミデスモソーム構成タンパク質の質量分析による網羅的解析          

    Grant number:20591341  2008.4 - 2011.3

    科学研究費補助金  基盤研究(C)

    平子 善章

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

  6. 180kD類天疱瘡抗原の細胞外C末端部位の切断機構の解明および疾患との関連の検証

    Grant number:17790762  2005.4 - 2007.3

    科学研究費補助金  若手研究(B)

    平子 善章

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3300000 ( Direct Cost: \3300000 )

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Teaching Experience (On-campus) 32

  1. 基礎生物学演習I

    2019

  2. 基礎細胞生物学

    2019

  3. 生物学実験

    2019

  4. Life Chemistry IIb

    2019

  5. Life Chemistry II

    2019

  6. 基礎生物学演習I

    2018

  7. 基礎細胞生物学

    2018

  8. 生物学実験

    2018

  9. 基礎生物学演習I

    2017

  10. 基礎細胞生物学

    2017

  11. 生物学実験

    2017

  12. 基礎生物学演習I

    2016

  13. 基礎細胞生物学

    2016

  14. 生物学実験

    2016

  15. 基礎生物学演習I

    2015

  16. 基礎細胞生物学

    2015

  17. 生物学実験

    2015

  18. 基礎生物学演習I

    2014

  19. 基礎細胞生物学

    2014

  20. 生物学実験

    2014

  21. 生物学実験

    2013

  22. 基礎セミナー

    2013

  23. 基礎細胞生物学

    2013

  24. 基礎生物学演習I

    2013

  25. 生物学実験

    2013

  26. 生物学基礎I

    2013

  27. 基礎細胞学

    2012

  28. 生物学基礎I

    2012

  29. 生物学実験

    2012

  30. 基礎生物学演習I

    2011

  31. 基礎細胞生物学

    2011

  32. 基礎細胞生物学

    2010

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