Faculty Profiles - KITA, Masaki

Papers - KITA, Masaki

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Mammalian neurotoxins, Blarina paralytic peptides, cause hyperpolarization of human T-type Ca channel hCa(v)3.2 activation. Reviewed

Yano Y, Fukuoka R, Maturana AD, Ohdachi SD, Kita M

The Journal of biological chemistry Vol. 299 ( 9 ) page： 105066 2023.9

Inhibition of Lysosomal Cathepsin A and Neuraminidase 1 Interaction by Anti-Obesity Cyclic Peptide. Reviewed

Sun Y, Dakiiwa A, Zhang M, Shibata T, Kita M

Chemistry (Weinheim an der Bergstrasse, Germany) Vol. 30 ( 56 ) page： e202402049 2024.10

Development of diazirine–alkyne tag for protein–ligand interaction analysis with photoaffinity labeling. Reviewed

(3) M. Nakatani, S. Ebihara, and M. Kita

Chemistry Letters Vol. 53 ( 8 ) page： upae142 2024.8

Development of actin dimerization inducers inspired by actin-depolymerizing macrolides. Reviewed

Itakura M, Utomo DH, Kita M

Chemical communications (Cambridge, England) Vol. 60 ( 37 ) page： 4910 - 4913 2024.5

Globunoids A-D, undescribed bichalconoid and biflavanoids with α-glucosidase and α-amylase inhibitory activities from Knema globularia stems. Reviewed International coauthorship

Le TK, Hioki Y, Duong TH, Kita M, Chavasiri W

Phytochemistry Vol. 221 page： 114066 2024.5

Identification and α-glucosidase inhibitory activity evaluation of two new coumarins derived from Mansonia gagei J. R. Drumm. Reviewed International coauthorship

Le HTT, Hioki Y, Nguyen DV, Le TK, Nguyen VK, Dang TT, Nguyen TA, Nguyen TH, Vu TH, Pham TK, Kita M, Chavasiri W

Natural product research page： 1 - 6 2024.2

A new neolignan and a new phenolic acid from the heartwood of Mansonia gagei J.R. Drumm. Reviewed International coauthorship

Le HTT, Yusuke H, Wonganan P, Le TK, Nguyen VK, Kita M, Chavasiri W

Natural product research Vol. 38 ( 2 ) page： 245 - 252 2024.1

Eriodictyol and thymonin act as GPR35 agonists. Reviewed International journal

Fumie Nakashima, Wei Qi Loh, Mayuka Wakabayashi, Sayako Shimomura, Hiroyuki Hattori, Masaki Kita, Asuka Inoue, Koji Uchida, Takahiro Shibata

Bioscience, biotechnology, and biochemistry Vol. 87 ( 12 ) page： 1514 - 1522 2023.11

Language：English Publishing type：Research paper (scientific journal)

Although herbs and spices have been used in traditional medicine for more than a century owing to their health benefits, the associated underlying mechanism is still not clear. Since the G protein-coupled receptor 35 (GPR35) has been linked to exert various antioxidant and anti-inflammatory effects, we screened 19 different herbs and spices for possible GPR35 agonist(s) to understand the GPR35-dependent functions on herbs and spices. Among the screened extracts, the ethyl acetate extract of thyme exhibited a remarkable GPR35 agonistic activity. Activity-guided separations allowed us to identify two polyphenolic phytochemicals, eriodictyol and thymonin, acting as GPR35 agonists. Both eriodictyol and thymonin showed a potent and specific agonist activity toward GPR35 with half maximal effective concentration values of 5.48 and 8.41 μM, respectively. These findings indicate that these phytochemicals may have beneficial health effects upon GPR35 activation.

DOI： 10.1093/bbb/zbad125

Web of Science

PubMed

α-Glucosidase inhibition of sesquiterpenoids from the heartwood of Mansonia gagei. Reviewed International coauthorship

Le HTT, Hioki Y, Danova A, Nguyen VK, Duong TH, Kita M, Chavasiri W

Phytochemistry Vol. 213 page： 113778 2023.9

魅力ある動物毒を追いかけて Invited Reviewed

北将樹

化学と工業 Vol. 76 ( 8 ) page： 548 - 549 2023.8

The asymmetric total synthesis and configuration confirmation of aplysiaenal and nhatrang A, truncated derivatives of aplysiatoxin and oscillatoxin Reviewed

M. Morishita, K. Hada, M. Kita, and T. Nishikawa

J. Nat. Prod. Vol. 86 ( 4 ) page： 1033 - 1041 2023.4

Discovery of New Cytotoxic Aplaminone Derivatives from the Sea Hare <i>Aplysia kurodai</i> and Elucidation of Their Accumulation from Local Sea Algae through the Food Chain Reviewed

Yusuke Hioki, Tatsuya Sato, Toyoki Iwao, Junya Ikuma, Atsushi Kawamura, Takayuki Ohyoshi, Yuta Tsunematsu, Masaki Kita

European Journal of Organic Chemistry Vol. 26 ( 12 ) 2023.2

Binding mode of actin–aplyronine A–tubulin heterotrimeric complex revealed by molecular dynamics simulation Reviewed

D. H. Utomo and M. Kita

Bull. Chem. Soc. Jpn. Vol. 96 ( 2 ) page： 120 - 126 2023.2

Dioscorea alata L. improves diabetes through anti-hyperglycemia, anti-inflammation, ameliorate insulin resistance and mitochondrial dysfunction Reviewed International coauthorship

S. N. N. Makiyah, M. Kita, I. Setyawati, and S. Tasminatun

Indones. Biomed. J. Vol. 14 ( 4 ) page： 365 - 375 2022.12

Ligand-Dissociation-Type N,N-Dimethylaminopyrene Probes for In-Situ Site-Specific Protein Labeling.

Tsuda T, Arai A, Kita M

Chemistry, an Asian journal Vol. 17 ( 18 ) page： e202200631 2022.9

Flavokawains, Plant-derived Chalcones, Inhibit Differentiation of Murine Pre-adipocytes Reviewed International coauthorship

Hanif, N; Iswantini, D; Hioki, Y; Murni, A; Kita, M; Tanaka, J

CHEMISTRY LETTERS Vol. 51 ( 1 ) page： 54 - 57 2022.1

The C29-C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags. Reviewed

Utomo DH, Fujieda A, Tanaka K, Takahashi M, Futaki K, Tanabe K, Kigoshi H, Kita M

Chemical communications (Cambridge, England) Vol. 57 ( 81 ) page： 10540 - 10543 2021.10

6-Paradol acts as a potential anti-obesity vanilloid from Grains of Paradise. Reviewed International journal

Hiroyuki Hattori, Takashi Mori, Takahiro Shibata, Masaki Kita, Tohru Mitsunaga

Molecular nutrition & food research Vol. 65 ( 16 ) page： e2100185 2021.8

Language：English Publishing type：Research paper (scientific journal)

SCOPE: Grains of Paradise (GOP), the seeds of Aframomum melegueta, has anti-obesity effects. However, the mechanisms underlying the effects remain unclear. METHODS AND RESULTS: We set up to study the anti-obesity impact and homeostatic effects of 6-paradol, a major vanilloid found in GOP, and investigated the physiological outputs and the lipometabolism-related gene in fat and liver in high-fat-induced obese mice with a comparison with structurally similar vanilloids (6-gingerol and 6-shogaol). The vanilloids were synthesized in adequate quantities for performing animal experiments and orally administered to six-week-old male mice over two weeks. We found that 6-paradol decreased body weight gain and visceral and subcutaneous fats in two weeks, whereas 6-gingerol and 6-shogaol had no effect. Additionally, 6-paradol suppressed the hepatic cholesterol and triglyceride and significantly decreased the gene expression related to fatty acid synthesis, lipid transportation, and adipocyte differentiation in both liver and adipose tissue. Moreover, phosphorylation of AMP-activated protein kinase (AMPK) that greatly contributes to lipometabolism was promoted by 6-gingerol but not 6-paradol. CONCLUSION: These results suggest that 6-paradol regulates several obesity-related genes in an AMPK-independent manner. Therefore, it could be the principal active vanilloid in GOP giving it anti-obesity properties with a different mechanism. This article is protected by copyright. All rights reserved.

DOI： 10.1002/mnfr.202100185

Web of Science

PubMed

Total synthesis and biological evaluation of oscillatoxins D, E, and F. Reviewed

Araki Y, Hanaki Y, Kita M, Hayakawa K, Irie K, Nokura Y, Nakazaki A, Nishikawa T

Bioscience, biotechnology, and biochemistry Vol. 85 ( 6 ) page： 1371 - 1382 2021.5

A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light Reviewed International coauthorship International journal

Osamu Kutomi, Ryosuke Yamamoto, Keiko Hirose, Katsutoshi Mizuno, Yuuhei Nakagiri, Hiroshi Imai, Akira Noga, Jagan Mohan Obbineni, Noemi Zimmermann, Masako Nakajima, Daisuke Shibata, Misa Shibata, Kogiku Shiba, Masaki Kita, Hideo Kigoshi, Yui Tanaka, Yuya Yamasaki, Yuma Asahina, Chihong Song, Mami Nomura, Mamoru Nomura, Ayako Nakajima, Mia Nakachi, Lixy Yamada, Shiori Nakazawa, Hitoshi Sawada, Kazuyoshi Murata, Kaoru Mitsuoka, Takashi Ishikawa, Ken-ichi Wakabayashi, Takahide Kon, Kazuo Inaba

Science Advances Vol. 7 ( 9 ) page： eabf3621 - eabf3621 2021.2

Language：English Publishing type：Research paper (scientific journal) Publisher：American Association for the Advancement of Science (AAAS)

Light-responsive regulation of ciliary motility is known to be conducted through modulation of dyneins, but the mechanism is not fully understood. Here, we report a novel subunit of the two-headed f/I1 inner arm dynein, named DYBLUP, in animal spermatozoa and a unicellular green alga. This subunit contains a BLUF (sensors of blue light using FAD) domain that appears to directly modulate dynein activity in response to light. DYBLUP (dynein-associated BLUF protein) mediates the connection between the f/I1 motor domain and the tether complex that links the motor to the doublet microtubule. <italic>Chlamydomonas</italic> lacking the DYBLUP ortholog shows both positive and negative phototaxis but becomes acclimated and attracted to high-intensity blue light. These results suggest a mechanism to avoid toxic strong light via direct photoregulation of dyneins.

DOI： 10.1126/sciadv.abf3621

Web of Science

PubMed

Discovery and Use of Natural Products and Derivatives as Chemical Probes Invited Reviewed

Kita, M; Kigoshi, H

DISCOVERY AND UTILITY OF CHEMICAL PROBES IN TARGET DISCOVERY Vol. 16 page： 124 - 149 2021

Acyl-CoA dehydrogenase long chain (ACADL) is a target protein of stylissatin A, an anti-inflammatory cyclic heptapeptide Reviewed

Menghua Zhang, Taiki Sunaba, Yiting Sun, Takahiro Shibata, Kazunori Sasaki, Hiroko Isoda, Hideo Kigoshi, Masaki Kita

The Journal of Antibiotics Vol. 73 ( 8 ) page： 589 - 592 2020.8

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Stylissatin A (SA) is a cyclic heptapeptide isolated from the marine sponge Stylissa massa. SA shows anti-inflammatory activity against lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cells, but the detailed mechanism of action remains unclear. Here we report that D-Tyr1-tBuSA, a more potent SA derivative, inhibited production of the proinflammatory cytokines Interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in LPS-stimulated RAW264.7 cells (EC50 = 1.4 and 5.9 μM, respectively). This compound also inhibited the LPS-stimulated expression of inducible nitric oxide synthase (iNOS) at 20 μM. Using a biotin derivative of SA, acyl-CoA dehydrogenase long chain (ACADL) was identified as a target protein of SA and its derivatives. It is proposed that SA and its derivatives might suppress the β-oxidation of fatty acids by ACADL, and the accumulation of fatty acids on macrophages would inhibit the nuclear factor-kappa B (NF-κB) signaling pathway and iNOS expression to show anti-inflammatory activity. Our research might provide a new mechanism of inflammation in macrophages, and contribute to the development of treatments for inflammatory diseases.

DOI： 10.1038/s41429-020-0322-5

Web of Science

PubMed

Other Link： http://www.nature.com/articles/s41429-020-0322-5

Isolation and structure–activity relationship studies of jacaranones: Anti-inflammatory quinoids from the Cuban endemic plant Jacaranda arborea (Bignoniaceae) Reviewed International coauthorship

Minako Hirukawa, Menghua Zhang, Lazaro M. Echenique–Diaz, Koji Mizota, Satoshi D. Ohdachi, Gerardo Begué–Quiala, Jorge L. Delgado–Labañino, Jorgelino Gámez–Díez, José Alvarez–Lemus, Leandro Galano Machado, Miguel Suárez Núñez, Takahiro Shibata, Hideo Kigoshi, Masaki Kita

Tetrahedron Letters Vol. 61 ( 26 ) page： 152005 - 152005 2020.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

The Cuban endemic plant Jacaranda arborea (Bignoniaceae) has been traditionally used in folk medicine as an acaricide and for acne treatment. Two known quinoids, methyl (1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate (jacaranone) (1) and its ethyl ester 2 were isolated from this species as anti-inflammatory substances. Compound 1 prominently inhibited the production of TNF-alpha in both LPS-treated macrophages and mice, with low toxicity. Structure-activity relationship studies revealed that the high electrophilicity of 1 as a Michael acceptor played an important role in these effects. Unlike in previous studies, such as those on antitumor, anti-oxidant, and anti-malarial activities, ester derivatives of 1 retained their potent anti-inflammatory activity. Our results suggest that jacaranones may target specific biomacromolecule(s) at lower concentrations than hitherto expected to exhibit potent activities. (C) 2020 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2020.152005

Web of Science

N,N-Dimethylaminopyrene as a fluorescent affinity mass tag for ligand-binding mode analysis Reviewed

Atsushi Arai, Rei Watanabe, Atsunori Hattori, Keita Iio, Yaping Hu, Kozo Yoneda, Hideo Kigoshi, Masaki Kita

Scientific Reports Vol. 10 ( 1 ) page： 7311 2020.4

哺乳類由来の神経毒の化学生物学研究

北将樹

化学工業 Vol. 71 page： 73 - 78 2020.1

A Glucosylated Steroid from the Active Fraction of Indonesian <i>Ficus deltoidea</i> Leaves Reviewed International coauthorship

Murni, A; Yuliansih, P; Mohamad, K; Kita, M; Hanif, N

8TH INTERNATIONAL CONFERENCE OF THE INDONESIAN CHEMICAL SOCIETY (ICICS)) 2019 Vol. 2243 2020

Post K-Pg diversification of the mammalian order Eulipotyphla as suggested by phylogenomic analyses of ultra-conserved elements. Reviewed

Sato JJ, Bradford TM, Armstrong KN, Donnellan SC, Echenique-Diaz LM, Begué-Quiala G, Gámez-Díez J, Yamaguchi N, Nguyen ST, Kita M, Ohdachi SD

Molecular phylogenetics and evolution Vol. 141 page： 106605 2019.12

生理活性蛍光リガンドとLA-LDI MS 〜標的生体分子の結合位置解析法の開発〜 Invited Reviewed

北将樹

生命化学研究レター Vol. 59 page： 7-11 2019.11

Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein-Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1-C9 Macrolactone Part and the C24-C34 Side Chain. Reviewed

Futaki K, Takahashi M, Tanabe K, Fujieda A, Kigoshi H, Kita M

ACS omega Vol. 4 ( 5 ) page： 8598 - 8613 2019.5

Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes. Reviewed

Zhang M, Sunaba T, Sun Y, Sasaki K, Isoda H, Kigoshi H, Kita M

Chemical communications (Cambridge, England) Vol. 55 ( 38 ) page： 5471 - 5474 2019.5

Pursue an Interdisciplinary Natural Products Chemist Invited Reviewed

Masaki Kita

Journal of Synthetic Organic Chemistry, Japan Vol. 77 ( 4 ) page： 371 - 373 2019.4

野生のキューバソレノドン（アルミキ）Solenodon cubanus の生態を垣間見る

大舘智志, ラザロエチェニケ–ディアス, ヘラルドベゲ–キアラ, 溝田浩二, 北将樹

哺乳類科学 Vol. 58 ( 2 ) page： 204 2018.12

Specific protein-labeling and ligand-binding position analysis with amidopyrene probes as LDI MS tags. Reviewed

Watanabe R, Hu Y, Iio K, Yoneda K, Hattori A, Arai A, Kigoshi H, Kita M

Organic & biomolecular chemistry Vol. 16 ( 42 ) page： 7883 - 7890 2018.10

Synthesis of the trisoxazole macrolactone of mycalolides via template-directed E-selective ring-closing metathesis Reviewed

Masaki Kita, Shun Watanabe, Hirotaka Oka, Hideo Kigoshi

Tetrahedron Letters Vol. 59 ( 41 ) page： 3664 - 3668 2018.10

Structure Analysis of Marine Natural Products and Their Binding Position Analysis on the Target Molecules by Using Mass Spectrometry

Kita Masaki

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN Vol. 76 ( 5 ) page： 442-445 2018.5

質量分析を用いた海洋天然物の構造解析および標的分子における結合位置解析 Invited Reviewed

北将樹

有機合成化学協会誌 Vol. 76 page： 442-445 2018.5

Sydowianumols A, B, and C, Three New Compounds from Discomycete Poculum pseudosydowianum Reviewed

Kawashima Daiki, Hosoya Tsuyoshi, Tomoda Hiroshi, Kita Masaki, Shigemori Hideyuki

CHEMICAL & PHARMACEUTICAL BULLETIN Vol. 66 ( 8 ) page： 826 - 829 2018

Structure analysis of marine natural products and their binding position analysis on the target molecules by using mass spectrometry Reviewed

Masaki Kita

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry Vol. 76 ( 5 ) page： 442 - 445 2018

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Society of Synthetic Organic Chemistry

In this review, two marine natural products, durinskiol A, a huge polyol compound from the cultured symbiotic dinoflagellate Durinskia sp., and aplyronine A, an antitumor macrolide from the sea hare Aplysia sp., are highlighted. We have developed a fluorescent labeling method for MS/MS analysis to establish the planar structure of durinskiol A. We also discovered 6-amidopyrene as a highly detectable tag for label-assisted laser desorption/ionization mass spectrometry (LA-LDI MS) without matrixes. Two amidopyrene derivatives of aplyronine A were synthesized, and their LA-LDI MS and MS/MS analyses to determine the binding position of the target protein actin are described.

DOI： 10.5059/yukigoseikyokaishi.76.442

Web of Science

Scopus

Development of photoaffinity derivatives of the antitumor macrolide aplyronine A, a PPI-inducer between actin and tubulin Reviewed

Masaki Kita, Kota Yamagishi, Kota Tsuchiya, Yu Seguchi, Hiroki Nakane, Hideo Kigoshi

BIOORGANIC & MEDICINAL CHEMISTRY Vol. 25 ( 24 ) page： 6322 - 6331 2017.12

Language：English Publishing type：Research paper (scientific journal) Publisher：PERGAMON-ELSEVIER SCIENCE LTD

The antitumor and actin-depolymerizing marine macrolide aplyronine A (ApA) synergistically binds to tubulin in association with actin, and prevents spindle formation and mitosis. While the crystal structure of the actin ApA complex was solved in 2006, its interaction with the tubulin heterodimer has not been clarified. To investigate the binding modes of ApA as a unique protein-protein interaction (PPI)-inducer between these two cytoskeletal proteins, we prepared its photoaffinity acetylene and fluorescent derivatives with the aid of molecular modeling studies for probe design. Among these three derivatives, the ApA-PPA-TAMRA probe specifically photoreacted with both actin and tubulin in vitro. However, the photolabeling yield of tubulin was quite low (up to similar to 1%), and one of the major side-reactions was the addition of a water molecule to the carbene species generated from an aryldiazirine moiety on the hydrophilic surface of actin. (C) 2017 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.bmc.2017.09.044

Web of Science

PubMed

哺乳類の神経毒 Invited

北　将樹

Clinical Neuroscience Vol. 35 page： 1453-1456 2017.12

タンパク質–リガンド相互作用を解析するアミドピレンプローブの開発. Invited

北将樹, 米田耕三, 胡亜萍, 渡邊礼, 木越英夫

日本ケミカルバイオロジー学会機関誌 Vol. 10 ( 1 ) page： 11-14 2017.6

Methyl 10-epi-pheophorbide A from MCF-7 cells active layer of the Indonesian Ficus deltoidea jack leaves. Reviewed

Anggia Murni, Novriyandi Hanif, Masaki Kita, Latifah K. Darusman

Int. J. Pharm. Pharm. Sci. Vol. 9 page： 183-186 2017.1

Identification of amino acids in antigen-binding site of class II HLA proteins independently associated with hepatitis B vaccine response. Reviewed

A. Sakai, E. Noguchi, T. Fukushima, M. Tagawa, A. Iwabuchi, M. Kita, K. Kakisaka, A. Miyasaka, Y. Takikawa, and R. Sumazaki

Vaccine Vol. 35 page： 703-710 2016.12

New cytotoxic norditerpenes from the Australian nudibranchs Goniobranchus splendidus and Goniobranchus daphne. Reviewed

Y. Hirayama, P. L. Katavic, A. M. White, G. K. Pierens, L. K. Lambert, A. E. Winters, H. Kigoshi, M. Kita, and M. J. Garson

Aust. J. Chem. Vol. 69 page： 136-144 2016

アクチン結合性天然物の新展開.

北将樹

化学工業 Vol. 67 page： 647-653 2016

毒を持つ哺乳類：珍獣キューバソレノドンとは？ Reviewed

北将樹

国立科学博物館雑誌Milsil Vol. 52 page： 17-19 2016

Binding position analysis of target proteins with the use of amidopyrene probes as LA-LDI enhancing tags. Reviewed

K. Yoneda, Y. Hu, R. Watanabe, M. Kita, and H. Kigoshi

Org. Biomol. Chem. Vol. 14 page： 8564-8569 2016

Molecular phylogenetic analysis of nuclear genes suggests a Cenozoic over-water dispersal origin for the Cuban solenodon.

J. J. Sato, S. D. Ohdachi, L. M. Echenique-Diaz, R. Borroto-Paez, G. Begue-Quiala, J. L. Delgado-Labanino, J. Gamez-Diez, J. Alvarez-Lemus, S. T. Nguyen, N. Yamaguchi, and M. Kita

Sci. Rep. Vol. 6 page： 31173 2016

Analysis of the aplyronine A-induced protein-protein interaction between actin and tubulin by surface plasmon resonance. Reviewed

Y. Hirayama, K. Yamagishi, T. Suzuki, H. Kawagishi, M. Kita, and H. Kigoshi

Bioorg. Med. Chem. Vol. 24 page： 2809-2814 2016

Aplysiasecosterols B and C: two new 9,11-secosteroids with a cis-fused 1,4-quinone structure from the sea hare Aplysia kurodai. Reviewed

M. Kita, A. Kawamura, and H. Kigoshi

Tetrahedron Lett. Vol. 57 page： 858-860 2016

カモノハシの毒． Reviewed

北将樹

現代化学 2015年6月号 page： 26 2015.6

Isolation, synthesis and nitric oxide reducing activity of compounds from the marine sponge Stylissa massa. Reviewed

T. Akindele, B. Gise, T. Sunaba, M. Kita, and H. Kigoshi

Bull. Chem. Soc. Jpn. Vol. 88 page： 600-609 2015

Marine natural products that regulate multiple cytoskeletal protein interactions. Reviewed

M. Kita and H. Kigoshi

Nat. Prod. Rep. Vol. 32 page： 534-542 2015

海洋産抗腫瘍物質アプロリニンAの作用機序. Reviewed

平山裕一郎, 北将樹, 木越英夫

化学と生物 Vol. 53 page： 164-170 2015

光親和性プローブを用いた抗腫瘍性天然物アプリロニンAの標的分子と作用機序の研究. Reviewed

北将樹, 木越英夫

有機合成化学協会誌 Vol. 73 page： 151-160 2015

Development of an aplyronine A photoaffinity amidopyrene derivative applicable for label-assisted LDI MS. Reviewed

K. Yoneda, Y. Hu, M. Kita, and H. Kigoshi

Sci. Rep. Vol. 5 page： 17853 2015

Total synthesis of mycalolides A and B through olefin metathesis. Reviewed

M. Kita, H. Oka, A. Usui, T. Ishitsuka, Y. Mogi, H. Watanabe, M. Tsunoda, M. Matsuki, and H. Kigoshi

Angew. Chem. Int. Ed. Vol. 54 page： 14174-14178 2015

Aplysiasecosterol A: a 9,11-secosteroid with an unprecedented tricyclic-gamma-diketone structure from the sea hare Aplysia kurodai. Reviewed

A. Kawamura, M. Kita, and H. Kigoshi

Angew. Chem. Int. Ed. Vol. 54 page： 7073-7076 2015

Assessing local people's knowledge of the endangered Cuban solenodon (Solenodon cubanus) in Alejandro de Humboldt national park, Cuba. Reviewed

L. M. Echenique-Diaz, S. D. Ohdachi, M. Kita, G. Begue-Quiala, R. Borroto, J. L. Delgado-Labanino, J. Damez-Diez, O. Hoson, and C. Saito

Research Bulletin of Environmental Education Center, Miyagi University of Education Vol. 16 page： 89-95 2014

ディビジョントピックス: リガンド解離型光親和性プローブ．

北将樹

化学と工業 Vol. 67 page： 1062 2014

Apoptosis-inducing activity of the actin-depolymerizing agent aplyronine A and its side-chain derivative. Reviewed

O. Ohno, M. Morita, K. Kitamura, T. Teruya, K. Yoneda, M. Kita, H. Kigoshi, and K. Suenaga

Bioorg. Med. Chem. Lett. Vol. 23 page： 1467-1471 2013

News & Views: 不飽和脂肪族アルコールがマウス嗅覚受容体のナチュラルリガンドとして作用する.

北将樹

日本ケミカルバイオロジー学会機関誌 Vol. 6 ( 2 ) page： 11 2013

キューバソレノドン（アルミキ）の多数捕獲の成功と調査顛末 Reviewed

大舘智志, 北将樹, ラザロ・ミゲル・エチェニケ・ディアス, ヘラルド・ベゲ・キアラ, 保尊脩

どうぶつと動物園 2013年冬号 page： 24-29 2013

Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A. Reviewed

M. Kita, Y. Hirayama, K. Yoneda, K. Yamagishi, T. Chinen, T. Usui, E. Sumiya, M. Uesugi, and H. Kigoshii

J. Am. Chem. Soc. Vol. 135 page： 18089-18095 2013

Stylissatin A, a cyclic peptide that inhibits nitric oxide production from the marine sponge Stylissa massa. Reviewed

M. Kita, B. Gise, A. Kawamura, and H. Kigoshi

Tetrahedron Lett. Vol. 54 page： 6826-6828 2013

Fluorescent aplyronine A: intracellular accumulation and disassembly of actin cytoskeleton in tumor cells. Reviewed

M. Kita, K. Yoneda, Y. Hirayama, K. Yamagishi, Y. Saito, Y. Sugiyama, Y. Miwa, O. Ohno, M. Morita, K. Suenaga, and H. Kigoshii

ChemBioChem Vol. 13 page： 1754-1758 2012

Bioorganic studies on the key natural products from venomous mammals and marine invertebrates. Reviewed

M. Kita

Bull. Chem. Soc. Jpn. Vol. 85 page： 1175-1185 2012

Bioorganic studies on the venom from duckbill platypus. Reviewed

M. Kita

Pure Appl. Chem. Vol. 84 page： 1317-1328 2012

Interactions of the antitumor macrolide aplyronine A with actin and actin-related proteins established by its versatile photoaffinity derivatives. Reviewed

M. Kita, Y. Hirayama, K. Yamagishi, K. Yoneda, R. Fujisawa, and H. Kigoshi

J. Am. Chem. Soc. Vol. 134 page： 20314-20317 2012

Synthesis and biological activities of the tris-oxazole macrolactone analogs of mycalolides. Reviewed

M. Kita, H. Oka, A. Usui, T. Ishitsuka, Y. Mogi, H. Watanabe, and H. Kigoshi

Tetrahedron Vol. 68 page： 8753-8760 2012

Development of highly cytotoxic and actin-depolymerizing biotin derivatives of aplyronine A. Reviewed

M. Kita, Y. Hirayama, M. Sugiyama, and H. Kigoshi

Angew. Chem. Int. Ed. Vol. 50 page： 9871-9874 2011

Synthetic studies of mycalolide B, an actin-depolymerizing marine macrolide: construction of the tris-oxazole macrolactone using ring-closing metathesis. Reviewed

M. Kita, H. Watanabe, T. Ishitsuka, Y. Mogi, and H. Kigoshi

Tetrahedron Lett. Vol. 51 page： 4882-4885 2010

Marine huge molecules: the longest carbon chains in natural products. Reviewed

M. Kita and D. Uemura

Chem. Rec. Vol. 10 page： 48-52 2010

飛翔する若手研究者:トガリネズミ, カモノハシ毒の謎に迫る–哺乳類の持つ毒の科学–

北将樹

化学と工業 Vol. 63 page： 739 2010

Bioactive secondary metabolites from symbiotic marine dinoflagellates: symbiodinolide and durinskiols. Reviewed

M. Kita, O. Ohno, C. Han, and D. Uemura

Chem. Rec. Vol. 10 page： 57-69 2010

Determination of absolute configuration of C14-C23 fragment in symbiodinolide. Reviewed

C. Han, Y. Yamano, M. Kita, H. Takamura, and D. Uemura

Tetrahedron Lett. Vol. 50 page： 5280-5282 2009

Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells. Reviewed

M. Kita, D. StC. Black, O. Ohno, K. Yamada, H. Kigoshi, and D. Uemura

Vol. 131 page： 18038-18039 2009

トガリネズミ、カモノハシ毒の謎に迫る -哺乳類の持つ毒の科学- Reviewed

北将樹

ビオフィリア Vol. 5 page： 29-33 2009

Recent aspects of chemical ecology. -natural toxins, coral communities, and symbiotic relationships- Reviewed

D. Uemura, M. Kita, H. Arimoto, and M. Kitamura

Pure Appl. Chem. Vol. 81 page： 1093-1111 2009

Biological, structural, and synthetic studies on (-)-ternatin, a potent fat accumulation inhibitor against 3T3-L1 adipocytes. Reviewed

K. Shimokawa, I. Mashima, A. Asai, K. Yamada, M. Kita, and D. Uemura

Chem. Asian J. Vol. 3 page： 438-446 2008

Structure-activity relationship of okadaic acid, a potent protein phosphatases PP1 and PP2A inhibitor: 24-epi-okadaic acid and a 18-membered lactone analog. Reviewed

M. Kita, M. Kuramoto, T. Chiba, A. Yamada, N. Yamada, T. Ishida, T. Haino, K. Yamada, Y. Ijuin, O. Ohno, and D. Uemura

Heterocycles Vol. 76 page： 1033-1042 2008

Structure of zamamistatin - a correction. Reviewed

M. Kita, Y. Tsunematsu, I. Hayakawa, and H. Kigoshi

Tetrahedron Lett. Vol. 49 page： 5383-5384 2008

Cyclic tetrapeptides from marine bacteria associated with the seaweed Diginea sp. and the sponge Halisarca ectofibrosa. Reviewed

W. Rungprom, L. K. Lambert, C. Dechsakulwatana, M. C. Barden, U. Kokpol, J. T. Blanchfield, E. R. O. Siwu, M. Kita, and M. J. Garson

Tetrahedron Vol. 64 page： 3147-3152 2008

Durinskiol B: A new durinskiol congener from the symbiotic marine dinoflagellate Durinskia sp. Reviewed

E. R. O. Siwu, O. Ohno, M. Kita, and D. Uemura

Chem. Lett. Vol. 37 page： 236-237 2008

Cytotoxic haterumadienone congeners from the Okinawan marine sponge Dysidea sp. Reviewed

Ueda, K.; Ogi, T.; Sato, A.; Siwu, E. R. O.; Kita, M.; Uemura, D.,

Heterocycles Vol. 72 page： 655-663 2007

注目の論文：ハチの性フェロモンを巧妙に利用する寄生昆虫 Invited Reviewed

北将樹

化学 Vol. 62 page： 56－57 2007

海洋共生藻由来の超炭素鎖有機分子 Invited Reviewed

北将樹、上村大輔

化学と生物 Vol. 45 page： 58－63 2007

Relative stereochemistries of the ether rings and sugar moieties in durinskiol A. Reviewed

Kita, M.; Roy, M. C.; Siwu, E. R. O.; Noma, I.; Takiguchi, T.; Yamada, K.; Koyama, T.; Iwashita, T.; Wakamiya, A.; Uemura, D.

Tetrahedron Lett. Vol. 48 page： 3429-3432 2007

Durinskiol A, a long carbon-chain polyol compound from the symbiotic dinoflagellate Durinskia sp. Reviewed

Kita, M.; Roy, M. C.; Siwu, E. R. O.; Noma, I.; Takiguchi, T.; Itoh, M.; Yamada, K.; Koyama, T.; Iwashita, T.; Uemura, D.,

Tetrahedron Lett. Vol. 48 page： 3423-3427 2007

Symbiodinolide, a novel polyol macrolide that activates N-type Ca2+ channel from the symbiotic dinoflagellate Symbiodinium sp. Invited Reviewed

Kita, M.; Ohishi, N.; Konishi, K.; Kondo, M.; Koyama, T.; Kitamura, M.; Yamada, K.; Uemura, D.

Tetrahedron page： in press 2007

Convergent synthesis and in vivo fat accumulation inhibitory effect of (-)-ternatin, a highly N-methylated cyclic peptide. Reviewed

K. Shimokawa, K. Yamada, M. Kita, and D. Uemura

Bioorg. Med. Chem. Lett. Vol. 17 page： 4447-4449 2007

Revised structure of kasarin, an antibacterial pyrazinone compound from the marine microorganism Hyphomycetes sp. Reviewed

M. Kita, R. Miwa, T. Widianti, Y. Ozaki, S. Aoyama, K. Yamada, and D. Uemura

Tetrahedron Lett. Vol. 48 page： 8628-8631 2007

Preparation of quinoline hexose analogs as novel chloroquine-resistant malaria treatments (1). Synthesis of 4-hydroxyquinoline-beta-glucosides. Reviewed

H. Suzuki, N. S. Aly, Y. Wataya, H. S. Kim, I. Tamai, M. Kita, and D. Uemura

Chem. Pharm. Bull. Vol. 55 page： 821-824 2007

Karatungiols A and B, two novel antimicrobial polyol compounds, from the symbiotic marine dinoflagellate Amphidinium sp Reviewed

Washida, K.; Koyama, T.; Yamada, K.; Kita, M.; Uemura, D.

Tetrahedron Lett., Vol. 47 page： 2521-2525 2006

海洋由来の生物活性物質の探索 Invited Reviewed

Vol. 64 page： 471-480 2006

Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: isolation, structure elucidation and structure-activity relationship. Reviewed

Uddin, J.; Ueda, K.; Siwu, E. R. O.; Kita, M.; Uemura, D.

Bioorg. Med. Chem. Vol. 14 page： 6954－6961 2006

Haterumadysins A-D: sesquiterpenes from the Okinawan marine sponge Dysidea chlorea. Reviewed

Ueda, K.; Kadekaru, T.; Siwu, E. R. O.; Kita, M.; Uemura, D.

J. Nat. Prod. Vol. 69 page： 1077－1079 2006

Stereochemistry of pteriatoxins A, B, and C. Reviewed

Hao, J.; Matsuura, F.; Kishi, Y.; Kita, M.; Uemura, D.; Asai, N.; Iwashita, T.

J. Am. Chem. Soc. Vol. 128 page： 7742-7743 2006

(-)-Ternatin, a highly N-methylated cyclic hepta-peptide that inhibits fat accumulation: structure and synthesis. Reviewed

Shimokawa, K.; Mashima, I.; Asai, A.; Yamada, K.; Kita, M.; Uemura, D.

Tetrahedron Lett. Vol. 47 page： 4445-4448 2006

Purification and characterisation of blarinasin, a new tissue kallikrein-like protease from the short-tailed shrew Blarina brevicauda - comparative studies with blarina toxin. Reviewed

Kita, M.; Okumura, Y.; Ohdachi, S. D.; Oba, Y.; Yoshikuni, M.; Nakamura, Y.; Kido, H.; Uemura, D.

Biol. Chem. Vol. 386 page： 177-182 2005

Haterumadienone: a new cytotoxic puupehenone congener from the Okinawan marine sponge Dysidea chlorea de Laubenfels. Reviewed

Ueda, K.; Ueta, T.; Siwu, E. R. O.; Kita, M.; Uemura, D.

Chem. Lett. Vol. 34 page： 1530-1531 2005

Feeding attractants for the muricid gastropod Drupella cornus, a coral predator. Reviewed

Kita, M.; Kitamura, M.; Koyama, T.; Teruya, T.; Matsumoto, H.; Nakano, Y.; Uemura, D.

Tetrahedron Lett. Vol. 46 page： 8583-8585 2005

Symbioimine and neosymbioimine, amphoteric iminium metabolites from the symbiotic dinoflagellate Symbiodinium sp. Invited Reviewed

Kita, M.; Ohishi, N.; Washida, K.; Kondo, M.; Koyama, T.; Yamada, K.; Uemura, D.

Bioorg. Med. Chem. Vol. 13 page： 5253-5258 2005

Iminium alkaloids from marine invertebrates: structure, biological activity, and biogenesis. Invited Reviewed

Kita, M.; Uemura, D.

Chem. Lett. Vol. 34 page： 454-459 2005

Symbioimine exhibiting inhibitory effect of osteoclast differentiation, from the symbiotic marine dinoflagellate Symbiodinium sp. Reviewed

Kita, M.; Kondo, M.; Koyama, T.; Yamada, K.; Matsumoto, T.; Lee, K. -H.; Woo, J. -T.; Uemura, D.

J. Am. Chem. Soc. Vol. 126 page： 4794-4795 2004

Nakiterpiosin and nakiterpiosinone, novel cytotoxic C-nor-D-homosteroids from the Okinawan sponge Terpios hoshinota Invited Reviewed

Teruya, T.; Nakagawa, S.; Koyama, T.; Arimoto, H.; Kita, M.; Uemura, D.

Tetrahedron Vol. 60 page： 6989-6993 2004

Blarina toxin, a mammalian lethal venom from the short-tailed shrew Blarina brevicauda: isolation and characterization. Reviewed

Kita, M.; Nakamura, Y.; Okumura, Y.; Ohdachi, S. D.; Oba, Y.; Yoshikuni, M.; Kido, H.; Uemura, D.

Proc. Natl. Acad. Sci. U.S.A. Vol. 101 page： 7542-7547 2004

Enantioselective synthesis of 15-epi-haterumalide NA methyl ester and revised structure of haterumalide NA. Reviewed

Kigoshi, H.; Kita, M.; Ogawa, S.; Itoh, M.; Uemura, D.

Org. Lett. Vol. 5 page： 957-960 2003

Nakiterpiosin, a novel cytotoxic C-nor-D-homosteroid from the Okinawan sponge Terpios hoshinota. Reviewed

Teruya, T.; Nakagawa, S.; Koyama, T.; Suenaga, K.; Kita, M.; Uemura, D.

Tetrahedron Lett. Vol. 44 page： 5171-5173 2003

米国ミシガン州における小哺乳類の捕獲調査

川田伸一郎、北将樹、Ashley Dowling

Vol. 5 page： 61-64 2003

A novel dipeptide, N-γ-glutamyl boletine, and a cyclic iminium toxin from the mushroom Tylopilus sp. (Boletaceae). Reviewed

Watanabe, R.; Kita, M.; Uemura, D.

Tetrahedron Lett. Vol. 43 page： 6501-6504 2002

Hedathiosulfonic acids A and B, novel thiosulfonic acids from the deep-sea urchin Echinocardium cordatum Invited Reviewed

Kita, M.; Watanabe, M.; Takada, N.; Suenaga, K.; Yamada, K.; Uemura, D.

Tetrahedron Vol. 58 page： 6405-6412 2002

未解明生物現象の化学 Invited Reviewed

有本博一、北将樹、上村大輔

化学工業 Vol. 52 page： 24-29 2002

北海道東部霧多布湿原地域における小型哺乳類相 Reviewed

岩佐真宏、大舘智氏、北将樹、内藤由香子、川窪千尋

環境教育研究 (北海道教育大学) Vol. 5 page： 47-52 2002

Zamamistatin, a significant antibacterial bromotyrosine derivative, from the Okinawan sponge Pseudoceratina purpurea Reviewed

Takada, N.; Watanabe, R.; Suenaga, K.; Yamada, K.; Ueda, K.; Kita, M.; Uemura, D.

Tetrahedron Lett. Vol. 42 page： 5265-5267 2001

Isolation and structures of hedathiosulfonic acids A and B, novel thiosulfonic acids from the deep-sea urchin Echinocardium cordatum Reviewed

Takada, N.; Watanabe, M.; Suenaga, K.; Yamada, K.; Kita, M.; Uemura, D.

Tetrahedron Lett. Vol. 42 page： 6557-6560 2001

Isolation and structure of korolkoside, a bis-iridoid glucoside from Lonicera korolkovii Reviewed

Kita, M.; Kigoshi, H.; Uemura, D.

J. Nat. Prod. Vol. 64 page： 1090-1092 2001

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