Faculty Profiles - KITA, Masaki

Papers - KITA, Masaki

Division display 1 - 20 of about 117 ／ All the affair displays >>

Mammalian neurotoxins, Blarina paralytic peptides, cause hyperpolarization of human T-type Ca channel hCa(v)3.2 activation. Reviewed

Yano Y, Fukuoka R, Maturana AD, Ohdachi SD, Kita M

The Journal of biological chemistry Vol. 299 ( 9 ) page： 105066 2023.9

Inhibition of Lysosomal Cathepsin A and Neuraminidase 1 Interaction by Anti-Obesity Cyclic Peptide. Reviewed

Sun Y, Dakiiwa A, Zhang M, Shibata T, Kita M

Chemistry (Weinheim an der Bergstrasse, Germany) Vol. 30 ( 56 ) page： e202402049 2024.10

Development of diazirine–alkyne tag for protein–ligand interaction analysis with photoaffinity labeling. Reviewed

(3) M. Nakatani, S. Ebihara, and M. Kita

Chemistry Letters Vol. 53 ( 8 ) page： upae142 2024.8

Development of actin dimerization inducers inspired by actin-depolymerizing macrolides. Reviewed

Itakura M, Utomo DH, Kita M

Chemical communications (Cambridge, England) Vol. 60 ( 37 ) page： 4910 - 4913 2024.5

Globunoids A-D, undescribed bichalconoid and biflavanoids with α-glucosidase and α-amylase inhibitory activities from Knema globularia stems. Reviewed International coauthorship

Le TK, Hioki Y, Duong TH, Kita M, Chavasiri W

Phytochemistry Vol. 221 page： 114066 2024.5

Identification and α-glucosidase inhibitory activity evaluation of two new coumarins derived from Mansonia gagei J. R. Drumm. Reviewed International coauthorship

Le HTT, Hioki Y, Nguyen DV, Le TK, Nguyen VK, Dang TT, Nguyen TA, Nguyen TH, Vu TH, Pham TK, Kita M, Chavasiri W

Natural product research page： 1 - 6 2024.2

A new neolignan and a new phenolic acid from the heartwood of Mansonia gagei J.R. Drumm. Reviewed International coauthorship

Le HTT, Yusuke H, Wonganan P, Le TK, Nguyen VK, Kita M, Chavasiri W

Natural product research Vol. 38 ( 2 ) page： 245 - 252 2024.1

Eriodictyol and thymonin act as GPR35 agonists. Reviewed International journal

Fumie Nakashima, Wei Qi Loh, Mayuka Wakabayashi, Sayako Shimomura, Hiroyuki Hattori, Masaki Kita, Asuka Inoue, Koji Uchida, Takahiro Shibata

Bioscience, biotechnology, and biochemistry Vol. 87 ( 12 ) page： 1514 - 1522 2023.11

Language：English Publishing type：Research paper (scientific journal)

Although herbs and spices have been used in traditional medicine for more than a century owing to their health benefits, the associated underlying mechanism is still not clear. Since the G protein-coupled receptor 35 (GPR35) has been linked to exert various antioxidant and anti-inflammatory effects, we screened 19 different herbs and spices for possible GPR35 agonist(s) to understand the GPR35-dependent functions on herbs and spices. Among the screened extracts, the ethyl acetate extract of thyme exhibited a remarkable GPR35 agonistic activity. Activity-guided separations allowed us to identify two polyphenolic phytochemicals, eriodictyol and thymonin, acting as GPR35 agonists. Both eriodictyol and thymonin showed a potent and specific agonist activity toward GPR35 with half maximal effective concentration values of 5.48 and 8.41 μM, respectively. These findings indicate that these phytochemicals may have beneficial health effects upon GPR35 activation.

DOI： 10.1093/bbb/zbad125

Web of Science

PubMed

α-Glucosidase inhibition of sesquiterpenoids from the heartwood of Mansonia gagei. Reviewed International coauthorship

Le HTT, Hioki Y, Danova A, Nguyen VK, Duong TH, Kita M, Chavasiri W

Phytochemistry Vol. 213 page： 113778 2023.9

魅力ある動物毒を追いかけて Invited Reviewed

北将樹

化学と工業 Vol. 76 ( 8 ) page： 548 - 549 2023.8

The asymmetric total synthesis and configuration confirmation of aplysiaenal and nhatrang A, truncated derivatives of aplysiatoxin and oscillatoxin Reviewed

M. Morishita, K. Hada, M. Kita, and T. Nishikawa

J. Nat. Prod. Vol. 86 ( 4 ) page： 1033 - 1041 2023.4

Discovery of New Cytotoxic Aplaminone Derivatives from the Sea Hare <i>Aplysia kurodai</i> and Elucidation of Their Accumulation from Local Sea Algae through the Food Chain Reviewed

Yusuke Hioki, Tatsuya Sato, Toyoki Iwao, Junya Ikuma, Atsushi Kawamura, Takayuki Ohyoshi, Yuta Tsunematsu, Masaki Kita

European Journal of Organic Chemistry Vol. 26 ( 12 ) 2023.2

Binding mode of actin–aplyronine A–tubulin heterotrimeric complex revealed by molecular dynamics simulation Reviewed

D. H. Utomo and M. Kita

Bull. Chem. Soc. Jpn. Vol. 96 ( 2 ) page： 120 - 126 2023.2

Dioscorea alata L. improves diabetes through anti-hyperglycemia, anti-inflammation, ameliorate insulin resistance and mitochondrial dysfunction Reviewed International coauthorship

S. N. N. Makiyah, M. Kita, I. Setyawati, and S. Tasminatun

Indones. Biomed. J. Vol. 14 ( 4 ) page： 365 - 375 2022.12

Ligand-Dissociation-Type N,N-Dimethylaminopyrene Probes for In-Situ Site-Specific Protein Labeling.

Tsuda T, Arai A, Kita M

Chemistry, an Asian journal Vol. 17 ( 18 ) page： e202200631 2022.9

Flavokawains, Plant-derived Chalcones, Inhibit Differentiation of Murine Pre-adipocytes Reviewed International coauthorship

Hanif, N; Iswantini, D; Hioki, Y; Murni, A; Kita, M; Tanaka, J

CHEMISTRY LETTERS Vol. 51 ( 1 ) page： 54 - 57 2022.1

The C29-C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags. Reviewed

Utomo DH, Fujieda A, Tanaka K, Takahashi M, Futaki K, Tanabe K, Kigoshi H, Kita M

Chemical communications (Cambridge, England) Vol. 57 ( 81 ) page： 10540 - 10543 2021.10

6-Paradol acts as a potential anti-obesity vanilloid from Grains of Paradise. Reviewed International journal

Hiroyuki Hattori, Takashi Mori, Takahiro Shibata, Masaki Kita, Tohru Mitsunaga

Molecular nutrition & food research Vol. 65 ( 16 ) page： e2100185 2021.8

Language：English Publishing type：Research paper (scientific journal)

SCOPE: Grains of Paradise (GOP), the seeds of Aframomum melegueta, has anti-obesity effects. However, the mechanisms underlying the effects remain unclear. METHODS AND RESULTS: We set up to study the anti-obesity impact and homeostatic effects of 6-paradol, a major vanilloid found in GOP, and investigated the physiological outputs and the lipometabolism-related gene in fat and liver in high-fat-induced obese mice with a comparison with structurally similar vanilloids (6-gingerol and 6-shogaol). The vanilloids were synthesized in adequate quantities for performing animal experiments and orally administered to six-week-old male mice over two weeks. We found that 6-paradol decreased body weight gain and visceral and subcutaneous fats in two weeks, whereas 6-gingerol and 6-shogaol had no effect. Additionally, 6-paradol suppressed the hepatic cholesterol and triglyceride and significantly decreased the gene expression related to fatty acid synthesis, lipid transportation, and adipocyte differentiation in both liver and adipose tissue. Moreover, phosphorylation of AMP-activated protein kinase (AMPK) that greatly contributes to lipometabolism was promoted by 6-gingerol but not 6-paradol. CONCLUSION: These results suggest that 6-paradol regulates several obesity-related genes in an AMPK-independent manner. Therefore, it could be the principal active vanilloid in GOP giving it anti-obesity properties with a different mechanism. This article is protected by copyright. All rights reserved.

DOI： 10.1002/mnfr.202100185

Web of Science

PubMed

Total synthesis and biological evaluation of oscillatoxins D, E, and F. Reviewed

Araki Y, Hanaki Y, Kita M, Hayakawa K, Irie K, Nokura Y, Nakazaki A, Nishikawa T

Bioscience, biotechnology, and biochemistry Vol. 85 ( 6 ) page： 1371 - 1382 2021.5

A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light Reviewed International coauthorship International journal

Osamu Kutomi, Ryosuke Yamamoto, Keiko Hirose, Katsutoshi Mizuno, Yuuhei Nakagiri, Hiroshi Imai, Akira Noga, Jagan Mohan Obbineni, Noemi Zimmermann, Masako Nakajima, Daisuke Shibata, Misa Shibata, Kogiku Shiba, Masaki Kita, Hideo Kigoshi, Yui Tanaka, Yuya Yamasaki, Yuma Asahina, Chihong Song, Mami Nomura, Mamoru Nomura, Ayako Nakajima, Mia Nakachi, Lixy Yamada, Shiori Nakazawa, Hitoshi Sawada, Kazuyoshi Murata, Kaoru Mitsuoka, Takashi Ishikawa, Ken-ichi Wakabayashi, Takahide Kon, Kazuo Inaba

Science Advances Vol. 7 ( 9 ) page： eabf3621 - eabf3621 2021.2

Language：English Publishing type：Research paper (scientific journal) Publisher：American Association for the Advancement of Science (AAAS)

Light-responsive regulation of ciliary motility is known to be conducted through modulation of dyneins, but the mechanism is not fully understood. Here, we report a novel subunit of the two-headed f/I1 inner arm dynein, named DYBLUP, in animal spermatozoa and a unicellular green alga. This subunit contains a BLUF (sensors of blue light using FAD) domain that appears to directly modulate dynein activity in response to light. DYBLUP (dynein-associated BLUF protein) mediates the connection between the f/I1 motor domain and the tether complex that links the motor to the doublet microtubule. <italic>Chlamydomonas</italic> lacking the DYBLUP ortholog shows both positive and negative phototaxis but becomes acclimated and attracted to high-intensity blue light. These results suggest a mechanism to avoid toxic strong light via direct photoregulation of dyneins.

DOI： 10.1126/sciadv.abf3621

Web of Science

PubMed

　 PREV - NEXT 　

<KITA, Masaki>

Papers - KITA, Masaki