Updated on 2023/10/11

写真a

 
KITA, Masaki
 
Organization
Graduate School of Bioagricultural Sciences Department of Applied Biosciences Professor
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences Department of Applied Biosciences
Title
Professor
Contact information
メールアドレス
External link

Degree 2

  1. D. Sc ( 2005.3   Nagoya University ) 

  2. MSc ( 2000.3   Nagoya University ) 

Research Interests 9

  1. Synthesis

  2. MS

  3. NMR

  4. Key Compounds Regulate Intriguing Phenomena

  5. Isolation and Structure

  6. Natural Products Chemistry

  7. Bioorganic Chemistry

  8. Natural Product Chemistry

  9. Chemical Biology

Research Areas 7

  1. Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules  / Living Organism Molecular Science

  2. Life Science / Bioorganic chemistry

  3. Nanotechnology/Materials / Chemical biology

  4. Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

  5. Nanotechnology/Materials / Chemical biology

  6. Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

  7. Life Science / Bioorganic chemistry

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Current Research Project and SDGs 4

  1. Anesthetic substances from shrew

  2. Studies on Bioactive Polyol compounds from Symbiotic Marine Dinoflagellates

  3. 蛍光プローブを用いた新たな標的分子の解析法の開発

  4. 海洋由来の抗腫瘍性, 抗炎症性物質の機能解明と有用リガンドの創出

Research History 12

  1. Nagoya University   Graduate School of Bioagricultural Sciences   Professor

    2017.4

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    Country:Japan

  2. Nagoya University   Graduate School of Bioagricultural Sciences   Professor

    2017.4

  3. JST   PRESTO   Researcher

    2015.10 - 2019.3

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    Country:Japan

  4. 筑波大学   博士課程教育リーディングプログラム・ヒューマンバイオロジー学位プログラム   准教授(兼任)

    2011.12 - 2017.3

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    Country:Japan

  5. University of Tsukuba   Graduate School of Pure and Applied Sciences   Associate professor

    2011.11 - 2017.3

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    Country:Japan

  6. University of Tsukuba   Faculty of Pure and Applied Sciences   Associate professor

    2011.11 - 2017.3

  7. University of Tsukuba   Faculty of Pure and Applied Sciences   Associate Professor

    2011.10

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    Country:Japan

  8. University of Tsukuba   Graduate School of Pure and Applied Sciences   Associate Professor

    2007.6 - 2011.9

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    Country:Japan

  9. Nagoya University   Research Center for Materials Science   Assistant Professor

    2007.4 - 2007.6

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    Country:Japan

  10. Nagoya University   Research Center for Materials Science   Associate Professor

    2002.7 - 2007.3

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    Country:Japan

  11. Nagoya University   Graduate School of Science   Associate Professor

    2001.9 - 2002.7

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    Country:Japan

  12. PRESTO-JST   Researcher

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Education 3

  1. Nagoya University   Graduate School, Division of Natural Science   Department of Chemistry

    2000.4 - 2001.8

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    Country: Japan

  2. Nagoya University   Graduate School, Division of Natural Science   Department of Chemistry

    1998.4 - 2000.3

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    Country: Japan

  3. Nagoya University   Faculty of Science   Department of Chemistry

    1995.4 - 1998.3

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    Country: Japan

Professional Memberships 4

  1. The Society of Organic Synthetic Chemistry, Japan

  2. The Chemical Society of Japan

  3. Japan Society for Chemical Biology

  4. ACS

Committee Memberships 11

  1. 第67回トキシンシンポジウム(名古屋・オンライン)実行委員長   実行委員長  

    2020.10 - 2021.9   

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    Committee type:Academic society

  2. 第62回天然有機化合物討論会(名古屋・オンライン)実行委員   実行委員  

    2019.10 - 2020.9   

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    Committee type:Academic society

  3. 日本ケミカルバイオロジー学会 第14回年会(名古屋)実行委員   実行委員  

    2018.7 - 2019.6   

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    Committee type:Academic society

  4. 日本化学会 東海支部 幹事   幹事  

    2018.4 - 2020.3   

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    Committee type:Academic society

  5. 日本農芸化学会 2018年度大会(名古屋)実行委員   実行委員  

    2017.4 - 2018.3   

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    Committee type:Academic society

  6. 筑波大学 大学戦略室 オブザーバー   オブザーバー  

    2016.4 - 2017.3   

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    Committee type:Other

  7. 筑波大学 大学戦略準備室 室員   室員  

    2015.7 - 2016.3   

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    Committee type:Other

  8. 科学技術予測センター 専門調査員   専門調査員  

    2015.4   

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    Committee type:Government

  9. 筑波大学 学長補佐   学長補佐  

    2015.4 - 2016.3   

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    Committee type:Other

  10. 毒素シンポジウム 運営委員   運営委員  

    2014.1 - 2016.12   

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    Committee type:Academic society

  11. 天然物化学談話会 世話人   世話人  

    2005.7 - 2015.6   

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    Committee type:Academic society

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Awards 12

  1. 筑波大学 FY2016 BEST FACULTY MEMBER 選出

    2017.2   筑波大学   有毒哺乳動物および海洋生物由来の鍵物質に関する化学的研究

    北将樹

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    Country:Japan

  2. 筑波大学 若手教員特別奨励賞

    2015.6   筑波大学   有毒哺乳動物および海洋生物由来の鍵物質に関する化学的研究

    北将樹

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    Country:Japan

  3. 平成27年度 科学技術分野の文部科学大臣表彰 若手科学者賞

    2015.4   文部科学省   有毒哺乳動物および海洋生物由来の鍵物質に関する化学的研究

    北将樹

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    Country:Japan

  4. 日本化学会 第61回 進歩賞

    2012.3   日本化学会   有毒哺乳動物および海洋無脊椎動物由来の生物活性鍵物質に関する化学的研究

    北将樹

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  5. 有機合成化学協会 2011年度 Meiji Seika ファルマ 研究企画賞

    2011.12   有機合成化学協会   抗腫瘍活性を有する海洋天然物アプリロニンAの光親和性プローブ合成と作用機序解明

    北将樹

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  6. 第1回 Prof. G. W. Ken Cavill Lectureship

    2011.11   豪州ニューサウスウェールズ大学  

    北将樹

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    Country:Japan

  7. 第52回天然有機化合物討論会 奨励賞(口頭)

    2010.10   天然有機化合物討論会   有毒哺乳動物カモノハシ由来の神経毒に関する生物有機化学的研究

    北将樹

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  8. 日本化学会 第24回若い世代の特別講演会 講演者 選出

    2010.3   日本化学会   哺乳動物由来の神経毒に関する生物有機化学的研究

    北将樹

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  9. 日本化学会 第89春季年会 優秀講演賞(学術)

    2009.3   日本化学会   有毒哺乳動物カモノハシ由来の神経毒に関する生物有機化学的研究

    北将樹

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  10. 天然物化学談話会 第6回奨励賞

    2006.7   天然物化学談話会  

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    Country:Japan

  11. 新規素材探索研究会 第5回奨励賞

    2006.6   新規素材探索研究会  

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    Country:Japan

  12. 井上科学振興財団 研究奨励賞

    2006.2   井上科学振興財団  

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    Country:Japan

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Papers 111

  1. Mammalian neurotoxins, Blarina paralytic peptides, cause hyperpolarization of human T-type Ca channel hCa(v)3.2 activation.

    Yano Y, Fukuoka R, Maturana AD, Ohdachi SD, Kita M

    The Journal of biological chemistry   Vol. 299 ( 9 ) page: 105066   2023.9

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    Language:English  

    DOI: 10.1016/j.jbc.2023.105066

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  2. Eriodictyol and thymonin act as GPR35 agonists.

    Nakashima F, Loh WQ, Wakabayashi M, Shimomura S, Hattori H, Kita M, Inoue A, Uchida K, Shibata T

    Bioscience, biotechnology, and biochemistry     2023.9

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    Language:English  

    DOI: 10.1093/bbb/zbad125

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  3. alpha-Glucosidase inhibition of sesquiterpenoids from the heartwood of Mansonia gagei

    Le Huong Thi Thu, Hioki Yusuke, Danova Ade, Nguyen Van-Kieu, Duong Thuc-Huy, Kita Masaki, Chavasiri Warinthorn

    PHYTOCHEMISTRY   Vol. 213   page: 113778   2023.9

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  4. 魅力ある動物毒を追いかけて Invited Reviewed

    北将樹

    化学と工業   Vol. 76 ( 8 ) page: 548 - 549   2023.8

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    Authorship:Lead author, Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (other academic)  

  5. The asymmetric total synthesis and configuration confirmation of aplysiaenal and nhatrang A, truncated derivatives of aplysiatoxin and oscillatoxin Reviewed

    M. Morishita, K. Hada, M. Kita, and T. Nishikawa

    J. Nat. Prod.   Vol. 86 ( 4 ) page: 1033 - 1041   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jnatprod.3c00077

    Web of Science

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  6. Discovery of New Cytotoxic Aplaminone Derivatives from the Sea Hare <i>Aplysia kurodai</i> and Elucidation of Their Accumulation from Local Sea Algae through the Food Chain

    Yusuke Hioki, Tatsuya Sato, Toyoki Iwao, Junya Ikuma, Atsushi Kawamura, Takayuki Ohyoshi, Yuta Tsunematsu, Masaki Kita

    European Journal of Organic Chemistry   Vol. 26 ( 12 )   2023.3

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1002/ejoc.202300084

    Web of Science

    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejoc.202300084

  7. Binding mode of actin–aplyronine A–tubulin heterotrimeric complex revealed by molecular dynamics simulation Reviewed

    D. H. Utomo and M. Kita

    Bull. Chem. Soc. Jpn.   Vol. 96 ( 2 ) page: 120 - 126   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/bcsj.20220299

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  8. Ligand-Dissociation-Type <i>N</i>,<i>N</i>-Dimethylaminopyrene Probes for In-Situ Site-Specific Protein Labeling

    Tsuda Tomohito, Arai Atsushi, Kita Masaki

    CHEMISTRY-AN ASIAN JOURNAL   Vol. 17 ( 18 ) page: e202200631   2022.9

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  9. Dioscorea alata L. improves diabetes through anti-hyperglycemia, anti-inflammation, ameliorate insulin resistance and mitochondrial dysfunction Reviewed International coauthorship

    S. N. N. Makiyah, M. Kita, I. Setyawati, and S. Tasminatun

    Indones. Biomed. J.   Vol. 14 ( 4 ) page: 365 - 375   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18585/inabj.v14i4.1966

  10. A new neolignan and a new phenolic acid from the heartwood of <i>Mansonia gagei</i> JR Drumm

    Le Huong Thi Thu, Yusuke Hioki, Wonganan Piyanuch, Le Thi-Kim-Dung, Nguyen Van-Kieu, Kita Masaki, Chavasiri Warinthorn

    NATURAL PRODUCT RESEARCH     page: 1 - 8   2022.8

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  11. Flavokawains, Plant-derived Chalcones, Inhibit Differentiation of Murine Pre-adipocytes Reviewed International coauthorship

    Hanif Novriyandi, Iswantini Dyah, Hioki Yusuke, Murni Anggia, Kita Masaki, Tanaka Junichi

    CHEMISTRY LETTERS   Vol. 51 ( 1 ) page: 54 - 57   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.210615

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  12. The C29-C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags Reviewed

    Utomo Didik Huswo, Fujieda Akari, Tanaka Kentaro, Takahashi Momoko, Futaki Kentaro, Tanabe Kenta, Kigoshi Hideo, Kita Masaki

    CHEMICAL COMMUNICATIONS   Vol. 57 ( 81 ) page: 10540 - 10543   2021.10

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d1cc04259a

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  13. 6-Paradol acts as a potential anti-obesity vanilloid from Grains of Paradise. Reviewed International journal

    Hiroyuki Hattori, Takashi Mori, Takahiro Shibata, Masaki Kita, Tohru Mitsunaga

    Molecular nutrition & food research   Vol. 65 ( 16 ) page: e2100185   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    SCOPE: Grains of Paradise (GOP), the seeds of Aframomum melegueta, has anti-obesity effects. However, the mechanisms underlying the effects remain unclear. METHODS AND RESULTS: We set up to study the anti-obesity impact and homeostatic effects of 6-paradol, a major vanilloid found in GOP, and investigated the physiological outputs and the lipometabolism-related gene in fat and liver in high-fat-induced obese mice with a comparison with structurally similar vanilloids (6-gingerol and 6-shogaol). The vanilloids were synthesized in adequate quantities for performing animal experiments and orally administered to six-week-old male mice over two weeks. We found that 6-paradol decreased body weight gain and visceral and subcutaneous fats in two weeks, whereas 6-gingerol and 6-shogaol had no effect. Additionally, 6-paradol suppressed the hepatic cholesterol and triglyceride and significantly decreased the gene expression related to fatty acid synthesis, lipid transportation, and adipocyte differentiation in both liver and adipose tissue. Moreover, phosphorylation of AMP-activated protein kinase (AMPK) that greatly contributes to lipometabolism was promoted by 6-gingerol but not 6-paradol. CONCLUSION: These results suggest that 6-paradol regulates several obesity-related genes in an AMPK-independent manner. Therefore, it could be the principal active vanilloid in GOP giving it anti-obesity properties with a different mechanism. This article is protected by copyright. All rights reserved.

    DOI: 10.1002/mnfr.202100185

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  14. Total synthesis and biological evaluation of oscillatoxins D, E, and F Reviewed

    Araki Yusuke, Hanaki Yusuke, Kita Masaki, Hayakawa Koutaro, Irie Kazuhiro, Nokura Yoshihiko, Nakazaki Atsuo, Nishikawa Toshio

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 85 ( 6 ) page: 1371 - 1382   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bbb/zbab042

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  15. A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light Reviewed International coauthorship International journal

    Osamu Kutomi, Ryosuke Yamamoto, Keiko Hirose, Katsutoshi Mizuno, Yuuhei Nakagiri, Hiroshi Imai, Akira Noga, Jagan Mohan Obbineni, Noemi Zimmermann, Masako Nakajima, Daisuke Shibata, Misa Shibata, Kogiku Shiba, Masaki Kita, Hideo Kigoshi, Yui Tanaka, Yuya Yamasaki, Yuma Asahina, Chihong Song, Mami Nomura, Mamoru Nomura, Ayako Nakajima, Mia Nakachi, Lixy Yamada, Shiori Nakazawa, Hitoshi Sawada, Kazuyoshi Murata, Kaoru Mitsuoka, Takashi Ishikawa, Ken-ichi Wakabayashi, Takahide Kon, Kazuo Inaba

    Science Advances   Vol. 7 ( 9 ) page: eabf3621 - eabf3621   2021.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:American Association for the Advancement of Science (AAAS)  

    Light-responsive regulation of ciliary motility is known to be conducted through modulation of dyneins, but the mechanism is not fully understood. Here, we report a novel subunit of the two-headed f/I1 inner arm dynein, named DYBLUP, in animal spermatozoa and a unicellular green alga. This subunit contains a BLUF (sensors of blue light using FAD) domain that appears to directly modulate dynein activity in response to light. DYBLUP (dynein-associated BLUF protein) mediates the connection between the f/I1 motor domain and the tether complex that links the motor to the doublet microtubule. <italic>Chlamydomonas</italic> lacking the DYBLUP ortholog shows both positive and negative phototaxis but becomes acclimated and attracted to high-intensity blue light. These results suggest a mechanism to avoid toxic strong light via direct photoregulation of dyneins.

    DOI: 10.1126/sciadv.abf3621

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  16. Acyl-CoA dehydrogenase long chain (ACADL) is a target protein of stylissatin A, an anti-inflammatory cyclic heptapeptide Reviewed

    Menghua Zhang, Taiki Sunaba, Yiting Sun, Takahiro Shibata, Kazunori Sasaki, Hiroko Isoda, Hideo Kigoshi, Masaki Kita

    The Journal of Antibiotics   Vol. 73 ( 8 ) page: 589 - 592   2020.8

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Stylissatin A (SA) is a cyclic heptapeptide isolated from the marine sponge Stylissa massa. SA shows anti-inflammatory activity against lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cells, but the detailed mechanism of action remains unclear. Here we report that D-Tyr1-tBuSA, a more potent SA derivative, inhibited production of the proinflammatory cytokines Interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in LPS-stimulated RAW264.7 cells (EC50 = 1.4 and 5.9 μM, respectively). This compound also inhibited the LPS-stimulated expression of inducible nitric oxide synthase (iNOS) at 20 μM. Using a biotin derivative of SA, acyl-CoA dehydrogenase long chain (ACADL) was identified as a target protein of SA and its derivatives. It is proposed that SA and its derivatives might suppress the β-oxidation of fatty acids by ACADL, and the accumulation of fatty acids on macrophages would inhibit the nuclear factor-kappa B (NF-κB) signaling pathway and iNOS expression to show anti-inflammatory activity. Our research might provide a new mechanism of inflammation in macrophages, and contribute to the development of treatments for inflammatory diseases.

    DOI: 10.1038/s41429-020-0322-5

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    Other Link: http://www.nature.com/articles/s41429-020-0322-5

  17. Isolation and structure–activity relationship studies of jacaranones: Anti-inflammatory quinoids from the Cuban endemic plant Jacaranda arborea (Bignoniaceae) Reviewed International coauthorship

    Minako Hirukawa, Menghua Zhang, Lazaro M. Echenique–Diaz, Koji Mizota, Satoshi D. Ohdachi, Gerardo Begué–Quiala, Jorge L. Delgado–Labañino, Jorgelino Gámez–Díez, José Alvarez–Lemus, Leandro Galano Machado, Miguel Suárez Núñez, Takahiro Shibata, Hideo Kigoshi, Masaki Kita

    Tetrahedron Letters   Vol. 61 ( 26 ) page: 152005 - 152005   2020.6

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    The Cuban endemic plant Jacaranda arborea (Bignoniaceae) has been traditionally used in folk medicine as an acaricide and for acne treatment. Two known quinoids, methyl (1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate (jacaranone) (1) and its ethyl ester 2 were isolated from this species as anti-inflammatory substances. Compound 1 prominently inhibited the production of TNF-alpha in both LPS-treated macrophages and mice, with low toxicity. Structure-activity relationship studies revealed that the high electrophilicity of 1 as a Michael acceptor played an important role in these effects. Unlike in previous studies, such as those on antitumor, anti-oxidant, and anti-malarial activities, ester derivatives of 1 retained their potent anti-inflammatory activity. Our results suggest that jacaranones may target specific biomacromolecule(s) at lower concentrations than hitherto expected to exhibit potent activities. (C) 2020 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.tetlet.2020.152005

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  18. N,N-Dimethylaminopyrene as a fluorescent affinity mass tag for ligand-binding mode analysis Reviewed

    Atsushi Arai, Rei Watanabe, Atsunori Hattori, Keita Iio, Yaping Hu, Kozo Yoneda, Hideo Kigoshi, Masaki Kita

    Scientific Reports   Vol. 10 ( 1 ) page: 7311   2020.4

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1038/s41598-020-64321-9

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    Other Link: http://www.nature.com/articles/s41598-020-64321-9

  19. 哺乳類由来の神経毒の化学生物学研究

    北将樹

    化学工業   Vol. 71   page: 73 - 78   2020.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  20. A Glucosylated Steroid from the Active Fraction of Indonesian <i>Ficus deltoidea</i> Leaves

    Murni A., Yuliansih P., Mohamad K., Kita M., Hanif N.

    8TH INTERNATIONAL CONFERENCE OF THE INDONESIAN CHEMICAL SOCIETY (ICICS)) 2019   Vol. 2243   2020

  21. Post K-Pg diversification of the mammalian order Eulipotyphla as suggested by phylogenomic analyses of ultra-conserved elements. Reviewed

    Sato JJ, Bradford TM, Armstrong KN, Donnellan SC, Echenique-Diaz LM, Begué-Quiala G, Gámez-Díez J, Yamaguchi N, Nguyen ST, Kita M, Ohdachi SD

    Molecular phylogenetics and evolution   Vol. 141   page: 106605   2019.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ympev.2019.106605

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  22. 生理活性蛍光リガンドとLA-LDI MS 〜標的生体分子の結合位置解析法の開発〜 Invited Reviewed

    北将樹

    生命化学研究レター   Vol. 59   page: 7-11   2019.11

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    Authorship:Lead author   Language:Japanese  

  23. Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes. Reviewed

    Zhang M, Sunaba T, Sun Y, Sasaki K, Isoda H, Kigoshi H, Kita M

    Chemical communications (Cambridge, England)   Vol. 55 ( 38 ) page: 5471 - 5474   2019.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c9cc02517k

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  24. Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein-Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1-C9 Macrolactone Part and the C24-C34 Side Chain. Reviewed

    Futaki K, Takahashi M, Tanabe K, Fujieda A, Kigoshi H, Kita M

    ACS omega   Vol. 4 ( 5 ) page: 8598 - 8613   2019.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsomega.9b01099

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  25. Pursue an Interdisciplinary Natural Products Chemist Invited Reviewed

    Masaki Kita

    Journal of Synthetic Organic Chemistry, Japan   Vol. 77 ( 4 ) page: 371 - 373   2019.4

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    Authorship:Lead author, Last author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:The Society of Synthetic Organic Chemistry, Japan  

    DOI: 10.5059/yukigoseikyokaishi.77.371

  26. 野生のキューバソレノドン(アルミキ)Solenodon cubanus の生態を垣間見る

    大舘智志, ラザロ エチェニケ–ディアス, ヘラルド ベゲ–キアラ, 溝田浩二, 北将樹

    哺乳類科学   Vol. 58 ( 2 ) page: 204   2018.12

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    Language:Japanese  

    DOI: 10.11238/mammalianscience.58.204

  27. Specific protein-labeling and ligand-binding position analysis with amidopyrene probes as LDI MS tags. Reviewed

    Watanabe R, Hu Y, Iio K, Yoneda K, Hattori A, Arai A, Kigoshi H, Kita M

    Organic & biomolecular chemistry   Vol. 16 ( 42 ) page: 7883 - 7890   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry ({RSC})  

    DOI: 10.1039/c8ob02222d

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  28. Synthesis of the trisoxazole macrolactone of mycalolides via template-directed E-selective ring-closing metathesis Reviewed

    Masaki Kita, Shun Watanabe, Hirotaka Oka, Hideo Kigoshi

    Tetrahedron Letters   Vol. 59 ( 41 ) page: 3664 - 3668   2018.10

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    DOI: 10.1016/j.tetlet.2018.08.058

    Web of Science

  29. Sydowianumols A, B, and C, Three New Compounds from Discomycete Poculum pseudosydowianum Reviewed

    Kawashima Daiki, Hosoya Tsuyoshi, Tomoda Hiroshi, Kita Masaki, Shigemori Hideyuki

    CHEMICAL & PHARMACEUTICAL BULLETIN   Vol. 66 ( 8 ) page: 826 - 829   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/cpb.c18-00264

    Web of Science

    PubMed

  30. Structure Analysis of Marine Natural Products and Their Binding Position Analysis on the Target Molecules by Using Mass Spectrometry

    Kita Masaki

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   Vol. 76 ( 5 ) page: 442-445   2018.5

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    Web of Science

  31. 質量分析を用いた海洋天然物の構造解析および標的分子における結合位置解析 Invited Reviewed

    北将樹

    有機合成化学協会誌   Vol. 76   page: 442-445   2018.5

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  32. Structure analysis of marine natural products and their binding position analysis on the target molecules by using mass spectrometry Reviewed

    Masaki Kita

    Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   Vol. 76 ( 5 ) page: 442 - 445   2018

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    In this review, two marine natural products, durinskiol A, a huge polyol compound from the cultured symbiotic dinoflagellate Durinskia sp., and aplyronine A, an antitumor macrolide from the sea hare Aplysia sp., are highlighted. We have developed a fluorescent labeling method for MS/MS analysis to establish the planar structure of durinskiol A. We also discovered 6-amidopyrene as a highly detectable tag for label-assisted laser desorption/ionization mass spectrometry (LA-LDI MS) without matrixes. Two amidopyrene derivatives of aplyronine A were synthesized, and their LA-LDI MS and MS/MS analyses to determine the binding position of the target protein actin are described.

    DOI: 10.5059/yukigoseikyokaishi.76.442

    Web of Science

    Scopus

  33. Development of photoaffinity derivatives of the antitumor macrolide aplyronine A, a PPI-inducer between actin and tubulin Reviewed

    Masaki Kita, Kota Yamagishi, Kota Tsuchiya, Yu Seguchi, Hiroki Nakane, Hideo Kigoshi

    BIOORGANIC & MEDICINAL CHEMISTRY   Vol. 25 ( 24 ) page: 6322 - 6331   2017.12

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    The antitumor and actin-depolymerizing marine macrolide aplyronine A (ApA) synergistically binds to tubulin in association with actin, and prevents spindle formation and mitosis. While the crystal structure of the actin ApA complex was solved in 2006, its interaction with the tubulin heterodimer has not been clarified. To investigate the binding modes of ApA as a unique protein-protein interaction (PPI)-inducer between these two cytoskeletal proteins, we prepared its photoaffinity acetylene and fluorescent derivatives with the aid of molecular modeling studies for probe design. Among these three derivatives, the ApA-PPA-TAMRA probe specifically photoreacted with both actin and tubulin in vitro. However, the photolabeling yield of tubulin was quite low (up to similar to 1%), and one of the major side-reactions was the addition of a water molecule to the carbene species generated from an aryldiazirine moiety on the hydrophilic surface of actin. (C) 2017 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bmc.2017.09.044

    Web of Science

    PubMed

  34. 哺乳類の神経毒 Invited

    北 将樹

    Clinical Neuroscience   Vol. 35   page: 1453-1456   2017.12

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  35. タンパク質–リガンド相互作用を解析するアミドピレンプローブの開発. Invited

    北将樹, 米田耕三, 胡亜萍, 渡邊礼, 木越英夫

    日本ケミカルバイオロジー学会機関誌   Vol. 10 ( 1 ) page: 11-14   2017.6

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    DOI: 11-14

  36. Methyl 10-epi-pheophorbide A from MCF-7 cells active layer of the Indonesian Ficus deltoidea jack leaves. Reviewed

    Anggia Murni, Novriyandi Hanif, Masaki Kita, Latifah K. Darusman

    Int. J. Pharm. Pharm. Sci.   Vol. 9   page: 183-186   2017.1

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    DOI: 10.22159/ijpps.2017v9i8.18750

  37. Identification of amino acids in antigen-binding site of class II HLA proteins independently associated with hepatitis B vaccine response. Reviewed

    A. Sakai, E. Noguchi, T. Fukushima, M. Tagawa, A. Iwabuchi, M. Kita, K. Kakisaka, A. Miyasaka, Y. Takikawa, and R. Sumazaki

    Vaccine   Vol. 35   page: 703-710   2016.12

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    DOI: 10.1016/j.vaccine.2016.08.068

  38. New cytotoxic norditerpenes from the Australian nudibranchs Goniobranchus splendidus and Goniobranchus daphne. Reviewed

    Y. Hirayama, P. L. Katavic, A. M. White, G. K. Pierens, L. K. Lambert, A. E. Winters, H. Kigoshi, M. Kita, and M. J. Garson

    Aust. J. Chem.   Vol. 69   page: 136-144   2016

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  39. アクチン結合性天然物の新展開.

    北将樹

    化学工業   Vol. 67   page: 647-653   2016

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  40. 毒を持つ哺乳類:珍獣キューバソレノドンとは? Reviewed

    北将樹

    国立科学博物館雑誌Milsil   Vol. 52   page: 17-19   2016

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  41. Binding position analysis of target proteins with the use of amidopyrene probes as LA-LDI enhancing tags. Reviewed

    K. Yoneda, Y. Hu, R. Watanabe, M. Kita, and H. Kigoshi

    Org. Biomol. Chem.   Vol. 14   page: 8564-8569   2016

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  42. Molecular phylogenetic analysis of nuclear genes suggests a Cenozoic over-water dispersal origin for the Cuban solenodon.

    J. J. Sato, S. D. Ohdachi, L. M. Echenique-Diaz, R. Borroto-Paez, G. Begue-Quiala, J. L. Delgado-Labanino, J. Gamez-Diez, J. Alvarez-Lemus, S. T. Nguyen, N. Yamaguchi, and M. Kita

    Sci. Rep.   Vol. 6   page: 31173   2016

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    DOI: 10.1038/srep31173

  43. Analysis of the aplyronine A-induced protein-protein interaction between actin and tubulin by surface plasmon resonance. Reviewed

    Y. Hirayama, K. Yamagishi, T. Suzuki, H. Kawagishi, M. Kita, and H. Kigoshi

    Bioorg. Med. Chem.   Vol. 24   page: 2809-2814   2016

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  44. Aplysiasecosterols B and C: two new 9,11-secosteroids with a cis-fused 1,4-quinone structure from the sea hare Aplysia kurodai. Reviewed

    M. Kita, A. Kawamura, and H. Kigoshi

    Tetrahedron Lett.   Vol. 57   page: 858-860   2016

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  45. カモノハシの毒. Reviewed

    北将樹

    現代化学 2015年6月号     page: 26   2015.6

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  46. Isolation, synthesis and nitric oxide reducing activity of compounds from the marine sponge Stylissa massa. Reviewed

    T. Akindele, B. Gise, T. Sunaba, M. Kita, and H. Kigoshi

    Bull. Chem. Soc. Jpn.   Vol. 88   page: 600-609   2015

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  47. Marine natural products that regulate multiple cytoskeletal protein interactions. Reviewed

    M. Kita and H. Kigoshi

    Nat. Prod. Rep.   Vol. 32   page: 534-542   2015

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  48. 海洋産抗腫瘍物質アプロリニンAの作用機序. Reviewed

    平山裕一郎, 北将樹, 木越英夫

    化学と生物   Vol. 53   page: 164-170   2015

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  49. 光親和性プローブを用いた抗腫瘍性天然物アプリロニンAの標的分子と作用機序の研究. Reviewed

    北将樹, 木越英夫

    有機合成化学協会誌   Vol. 73   page: 151-160   2015

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  50. Development of an aplyronine A photoaffinity amidopyrene derivative applicable for label-assisted LDI MS. Reviewed

    K. Yoneda, Y. Hu, M. Kita, and H. Kigoshi

    Sci. Rep.   Vol. 5   page: 17853   2015

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    DOI: 10.1038/srep17853

  51. Total synthesis of mycalolides A and B through olefin metathesis. Reviewed

    M. Kita, H. Oka, A. Usui, T. Ishitsuka, Y. Mogi, H. Watanabe, M. Tsunoda, M. Matsuki, and H. Kigoshi

    Angew. Chem. Int. Ed.   Vol. 54   page: 14174-14178   2015

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  52. Aplysiasecosterol A: a 9,11-secosteroid with an unprecedented tricyclic-gamma-diketone structure from the sea hare Aplysia kurodai. Reviewed

    A. Kawamura, M. Kita, and H. Kigoshi

    Angew. Chem. Int. Ed.   Vol. 54   page: 7073-7076   2015

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  53. Assessing local people's knowledge of the endangered Cuban solenodon (Solenodon cubanus) in Alejandro de Humboldt national park, Cuba. Reviewed

    L. M. Echenique-Diaz, S. D. Ohdachi, M. Kita, G. Begue-Quiala, R. Borroto, J. L. Delgado-Labanino, J. Damez-Diez, O. Hoson, and C. Saito

    Research Bulletin of Environmental Education Center, Miyagi University of Education   Vol. 16   page: 89-95   2014

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  54. ディビジョントピックス: リガンド解離型光親和性プローブ.

    北将樹

    化学と工業   Vol. 67   page: 1062   2014

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  55. Apoptosis-inducing activity of the actin-depolymerizing agent aplyronine A and its side-chain derivative. Reviewed

    O. Ohno, M. Morita, K. Kitamura, T. Teruya, K. Yoneda, M. Kita, H. Kigoshi, and K. Suenaga

    Bioorg. Med. Chem. Lett.   Vol. 23   page: 1467-1471   2013

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  56. News & Views: 不飽和脂肪族アルコールがマウス嗅覚受容体のナチュラルリガンドとして作用する.

    北将樹

    日本ケミカルバイオロジー学会機関誌   Vol. 6 ( 2 ) page: 11   2013

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  57. キューバソレノドン(アルミキ)の多数捕獲の成功と調査顛末 Reviewed

    大舘智志, 北将樹, ラザロ・ミゲル・エチェニケ・ディアス, ヘラルド・ベゲ・キアラ, 保尊脩

    どうぶつと動物園 2013年冬号     page: 24-29   2013

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  58. Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A. Reviewed

    M. Kita, Y. Hirayama, K. Yoneda, K. Yamagishi, T. Chinen, T. Usui, E. Sumiya, M. Uesugi, and H. Kigoshii

    J. Am. Chem. Soc.   Vol. 135   page: 18089-18095   2013

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  59. Stylissatin A, a cyclic peptide that inhibits nitric oxide production from the marine sponge Stylissa massa. Reviewed

    M. Kita, B. Gise, A. Kawamura, and H. Kigoshi

    Tetrahedron Lett.   Vol. 54   page: 6826-6828   2013

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  60. Fluorescent aplyronine A: intracellular accumulation and disassembly of actin cytoskeleton in tumor cells. Reviewed

    M. Kita, K. Yoneda, Y. Hirayama, K. Yamagishi, Y. Saito, Y. Sugiyama, Y. Miwa, O. Ohno, M. Morita, K. Suenaga, and H. Kigoshii

    ChemBioChem   Vol. 13   page: 1754-1758   2012

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  61. Bioorganic studies on the key natural products from venomous mammals and marine invertebrates. Reviewed

    M. Kita

    Bull. Chem. Soc. Jpn.   Vol. 85   page: 1175-1185   2012

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  62. Bioorganic studies on the venom from duckbill platypus. Reviewed

    M. Kita

    Pure Appl. Chem.   Vol. 84   page: 1317-1328   2012

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  63. Interactions of the antitumor macrolide aplyronine A with actin and actin-related proteins established by its versatile photoaffinity derivatives. Reviewed

    M. Kita, Y. Hirayama, K. Yamagishi, K. Yoneda, R. Fujisawa, and H. Kigoshi

    J. Am. Chem. Soc.   Vol. 134   page: 20314-20317   2012

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  64. Synthesis and biological activities of the tris-oxazole macrolactone analogs of mycalolides. Reviewed

    M. Kita, H. Oka, A. Usui, T. Ishitsuka, Y. Mogi, H. Watanabe, and H. Kigoshi

    Tetrahedron   Vol. 68   page: 8753-8760   2012

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  65. Development of highly cytotoxic and actin-depolymerizing biotin derivatives of aplyronine A. Reviewed

    M. Kita, Y. Hirayama, M. Sugiyama, and H. Kigoshi

    Angew. Chem. Int. Ed.   Vol. 50   page: 9871-9874   2011

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  66. Synthetic studies of mycalolide B, an actin-depolymerizing marine macrolide: construction of the tris-oxazole macrolactone using ring-closing metathesis. Reviewed

    M. Kita, H. Watanabe, T. Ishitsuka, Y. Mogi, and H. Kigoshi

    Tetrahedron Lett.   Vol. 51   page: 4882-4885   2010

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  67. 飛翔する若手研究者:トガリネズミ, カモノハシ毒の謎に迫る–哺乳類の持つ毒の科学–

    北将樹

    化学と工業   Vol. 63   page: 739   2010

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  68. Bioactive secondary metabolites from symbiotic marine dinoflagellates: symbiodinolide and durinskiols. Reviewed

    M. Kita, O. Ohno, C. Han, and D. Uemura

    Chem. Rec.   Vol. 10   page: 57-69   2010

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  69. Marine huge molecules: the longest carbon chains in natural products. Reviewed

    M. Kita and D. Uemura

    Chem. Rec.   Vol. 10   page: 48-52   2010

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  70. Determination of absolute configuration of C14-C23 fragment in symbiodinolide. Reviewed

    C. Han, Y. Yamano, M. Kita, H. Takamura, and D. Uemura

    Tetrahedron Lett.   Vol. 50   page: 5280-5282   2009

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  71. Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells. Reviewed

    M. Kita, D. StC. Black, O. Ohno, K. Yamada, H. Kigoshi, and D. Uemura

      Vol. 131   page: 18038-18039   2009

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  72. トガリネズミ、カモノハシ毒の謎に迫る -哺乳類の持つ毒の科学- Reviewed

    北将樹

    ビオフィリア   Vol. 5   page: 29-33   2009

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  73. Recent aspects of chemical ecology. -natural toxins, coral communities, and symbiotic relationships- Reviewed

    D. Uemura, M. Kita, H. Arimoto, and M. Kitamura

    Pure Appl. Chem.   Vol. 81   page: 1093-1111   2009

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  74. Biological, structural, and synthetic studies on (-)-ternatin, a potent fat accumulation inhibitor against 3T3-L1 adipocytes. Reviewed

    K. Shimokawa, I. Mashima, A. Asai, K. Yamada, M. Kita, and D. Uemura

    Chem. Asian J.   Vol. 3   page: 438-446   2008

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  75. Structure-activity relationship of okadaic acid, a potent protein phosphatases PP1 and PP2A inhibitor: 24-epi-okadaic acid and a 18-membered lactone analog. Reviewed

    M. Kita, M. Kuramoto, T. Chiba, A. Yamada, N. Yamada, T. Ishida, T. Haino, K. Yamada, Y. Ijuin, O. Ohno, and D. Uemura

    Heterocycles   Vol. 76   page: 1033-1042   2008

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  76. Structure of zamamistatin - a correction. Reviewed

    M. Kita, Y. Tsunematsu, I. Hayakawa, and H. Kigoshi

    Tetrahedron Lett.   Vol. 49   page: 5383-5384   2008

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  77. Cyclic tetrapeptides from marine bacteria associated with the seaweed Diginea sp. and the sponge Halisarca ectofibrosa. Reviewed

    W. Rungprom, L. K. Lambert, C. Dechsakulwatana, M. C. Barden, U. Kokpol, J. T. Blanchfield, E. R. O. Siwu, M. Kita, and M. J. Garson

    Tetrahedron   Vol. 64   page: 3147-3152   2008

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  78. Durinskiol B: A new durinskiol congener from the symbiotic marine dinoflagellate Durinskia sp. Reviewed

    E. R. O. Siwu, O. Ohno, M. Kita, and D. Uemura

    Chem. Lett.   Vol. 37   page: 236-237   2008

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  79. Cytotoxic haterumadienone congeners from the Okinawan marine sponge Dysidea sp. Reviewed

    Ueda, K.; Ogi, T.; Sato, A.; Siwu, E. R. O.; Kita, M.; Uemura, D.,

    Heterocycles   Vol. 72   page: 655-663   2007

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  80. 注目の論文:ハチの性フェロモンを巧妙に利用する寄生昆虫 Invited Reviewed

    北将樹

    化学   Vol. 62   page: 56-57   2007

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  81. 海洋共生藻由来の超炭素鎖有機分子 Invited Reviewed

    北将樹、上村大輔

    化学と生物   Vol. 45   page: 58-63   2007

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  82. Relative stereochemistries of the ether rings and sugar moieties in durinskiol A. Reviewed

    Kita, M.; Roy, M. C.; Siwu, E. R. O.; Noma, I.; Takiguchi, T.; Yamada, K.; Koyama, T.; Iwashita, T.; Wakamiya, A.; Uemura, D.

    Tetrahedron Lett.   Vol. 48   page: 3429-3432   2007

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  83. Durinskiol A, a long carbon-chain polyol compound from the symbiotic dinoflagellate Durinskia sp. Reviewed

    Kita, M.; Roy, M. C.; Siwu, E. R. O.; Noma, I.; Takiguchi, T.; Itoh, M.; Yamada, K.; Koyama, T.; Iwashita, T.; Uemura, D.,

    Tetrahedron Lett.   Vol. 48   page: 3423-3427   2007

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  84. Symbiodinolide, a novel polyol macrolide that activates N-type Ca2+ channel from the symbiotic dinoflagellate Symbiodinium sp. Invited Reviewed

    Kita, M.; Ohishi, N.; Konishi, K.; Kondo, M.; Koyama, T.; Kitamura, M.; Yamada, K.; Uemura, D.

    Tetrahedron     page: in press   2007

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  85. Convergent synthesis and in vivo fat accumulation inhibitory effect of (-)-ternatin, a highly N-methylated cyclic peptide. Reviewed

    K. Shimokawa, K. Yamada, M. Kita, and D. Uemura

    Bioorg. Med. Chem. Lett.   Vol. 17   page: 4447-4449   2007

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  86. Revised structure of kasarin, an antibacterial pyrazinone compound from the marine microorganism Hyphomycetes sp. Reviewed

    M. Kita, R. Miwa, T. Widianti, Y. Ozaki, S. Aoyama, K. Yamada, and D. Uemura

    Tetrahedron Lett.   Vol. 48   page: 8628-8631   2007

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  87. Preparation of quinoline hexose analogs as novel chloroquine-resistant malaria treatments (1). Synthesis of 4-hydroxyquinoline-beta-glucosides. Reviewed

    H. Suzuki, N. S. Aly, Y. Wataya, H. S. Kim, I. Tamai, M. Kita, and D. Uemura

    Chem. Pharm. Bull.   Vol. 55   page: 821-824   2007

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  88. Karatungiols A and B, two novel antimicrobial polyol compounds, from the symbiotic marine dinoflagellate Amphidinium sp Reviewed

    Washida, K.; Koyama, T.; Yamada, K.; Kita, M.; Uemura, D.

    Tetrahedron Lett.,   Vol. 47   page: 2521-2525   2006

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  89. 海洋由来の生物活性物質の探索 Invited Reviewed

      Vol. 64   page: 471-480   2006

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  90. Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: isolation, structure elucidation and structure-activity relationship. Reviewed

    Uddin, J.; Ueda, K.; Siwu, E. R. O.; Kita, M.; Uemura, D.

    Bioorg. Med. Chem.   Vol. 14   page: 6954-6961   2006

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  91. Haterumadysins A-D: sesquiterpenes from the Okinawan marine sponge Dysidea chlorea. Reviewed

    Ueda, K.; Kadekaru, T.; Siwu, E. R. O.; Kita, M.; Uemura, D.

    J. Nat. Prod.   Vol. 69   page: 1077-1079   2006

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  92. Stereochemistry of pteriatoxins A, B, and C. Reviewed

    Hao, J.; Matsuura, F.; Kishi, Y.; Kita, M.; Uemura, D.; Asai, N.; Iwashita, T.

    J. Am. Chem. Soc.   Vol. 128   page: 7742-7743   2006

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  93. (-)-Ternatin, a highly N-methylated cyclic hepta-peptide that inhibits fat accumulation: structure and synthesis. Reviewed

    Shimokawa, K.; Mashima, I.; Asai, A.; Yamada, K.; Kita, M.; Uemura, D.

    Tetrahedron Lett.   Vol. 47   page: 4445-4448   2006

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  94. Purification and characterisation of blarinasin, a new tissue kallikrein-like protease from the short-tailed shrew Blarina brevicauda - comparative studies with blarina toxin. Reviewed

    Kita, M.; Okumura, Y.; Ohdachi, S. D.; Oba, Y.; Yoshikuni, M.; Nakamura, Y.; Kido, H.; Uemura, D.

    Biol. Chem.   Vol. 386   page: 177-182   2005

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  95. Haterumadienone: a new cytotoxic puupehenone congener from the Okinawan marine sponge Dysidea chlorea de Laubenfels. Reviewed

    Ueda, K.; Ueta, T.; Siwu, E. R. O.; Kita, M.; Uemura, D.

    Chem. Lett.   Vol. 34   page: 1530-1531   2005

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  96. Feeding attractants for the muricid gastropod Drupella cornus, a coral predator. Reviewed

    Kita, M.; Kitamura, M.; Koyama, T.; Teruya, T.; Matsumoto, H.; Nakano, Y.; Uemura, D.

    Tetrahedron Lett.   Vol. 46   page: 8583-8585   2005

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  97. Symbioimine and neosymbioimine, amphoteric iminium metabolites from the symbiotic dinoflagellate Symbiodinium sp. Invited Reviewed

    Kita, M.; Ohishi, N.; Washida, K.; Kondo, M.; Koyama, T.; Yamada, K.; Uemura, D.

    Bioorg. Med. Chem.   Vol. 13   page: 5253-5258   2005

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  98. Iminium alkaloids from marine invertebrates: structure, biological activity, and biogenesis. Invited Reviewed

    Kita, M.; Uemura, D.

    Chem. Lett.   Vol. 34   page: 454-459   2005

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    (Highlight Review)

  99. Symbioimine exhibiting inhibitory effect of osteoclast differentiation, from the symbiotic marine dinoflagellate Symbiodinium sp. Reviewed

    Kita, M.; Kondo, M.; Koyama, T.; Yamada, K.; Matsumoto, T.; Lee, K. -H.; Woo, J. -T.; Uemura, D.

    J. Am. Chem. Soc.   Vol. 126   page: 4794-4795   2004

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  100. Nakiterpiosin and nakiterpiosinone, novel cytotoxic C-nor-D-homosteroids from the Okinawan sponge Terpios hoshinota Invited Reviewed

    Teruya, T.; Nakagawa, S.; Koyama, T.; Arimoto, H.; Kita, M.; Uemura, D.

    Tetrahedron   Vol. 60   page: 6989-6993   2004

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  101. Blarina toxin, a mammalian lethal venom from the short-tailed shrew Blarina brevicauda: isolation and characterization. Reviewed

    Kita, M.; Nakamura, Y.; Okumura, Y.; Ohdachi, S. D.; Oba, Y.; Yoshikuni, M.; Kido, H.; Uemura, D.

    Proc. Natl. Acad. Sci. U.S.A.   Vol. 101   page: 7542-7547   2004

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  102. Enantioselective synthesis of 15-epi-haterumalide NA methyl ester and revised structure of haterumalide NA. Reviewed

    Kigoshi, H.; Kita, M.; Ogawa, S.; Itoh, M.; Uemura, D.

    Org. Lett.   Vol. 5   page: 957-960   2003

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  103. Nakiterpiosin, a novel cytotoxic C-nor-D-homosteroid from the Okinawan sponge Terpios hoshinota. Reviewed

    Teruya, T.; Nakagawa, S.; Koyama, T.; Suenaga, K.; Kita, M.; Uemura, D.

    Tetrahedron Lett.   Vol. 44   page: 5171-5173   2003

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  104. 米国ミシガン州における小哺乳類の捕獲調査

    川田伸一郎、北将樹、Ashley Dowling

      Vol. 5   page: 61-64   2003

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    Authorship:Lead author   Language:Japanese  

  105. Hedathiosulfonic acids A and B, novel thiosulfonic acids from the deep-sea urchin Echinocardium cordatum Invited Reviewed

    Kita, M.; Watanabe, M.; Takada, N.; Suenaga, K.; Yamada, K.; Uemura, D.

    Tetrahedron   Vol. 58   page: 6405-6412   2002

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  106. A novel dipeptide, N-γ-glutamyl boletine, and a cyclic iminium toxin from the mushroom Tylopilus sp. (Boletaceae). Reviewed

    Watanabe, R.; Kita, M.; Uemura, D.

    Tetrahedron Lett.   Vol. 43   page: 6501-6504   2002

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  107. 未解明生物現象の化学 Invited Reviewed

    有本博一、北将樹、上村大輔

    化学工業   Vol. 52   page: 24-29   2002

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    Authorship:Lead author   Language:Japanese  

  108. 北海道東部霧多布湿原地域における小型哺乳類相 Reviewed

    岩佐真宏、大舘智氏、北将樹、内藤由香子、川窪千尋

    環境教育研究 (北海道教育大学)   Vol. 5   page: 47-52   2002

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    Authorship:Lead author   Language:Japanese  

  109. Isolation and structure of korolkoside, a bis-iridoid glucoside from Lonicera korolkovii Reviewed

    Kita, M.; Kigoshi, H.; Uemura, D.

    J. Nat. Prod.   Vol. 64   page: 1090-1092   2001

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  110. Zamamistatin, a significant antibacterial bromotyrosine derivative, from the Okinawan sponge Pseudoceratina purpurea Reviewed

    Takada, N.; Watanabe, R.; Suenaga, K.; Yamada, K.; Ueda, K.; Kita, M.; Uemura, D.

    Tetrahedron Lett.   Vol. 42   page: 5265-5267   2001

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  111. Isolation and structures of hedathiosulfonic acids A and B, novel thiosulfonic acids from the deep-sea urchin Echinocardium cordatum Reviewed

    Takada, N.; Watanabe, M.; Suenaga, K.; Yamada, K.; Kita, M.; Uemura, D.

    Tetrahedron Lett.   Vol. 42   page: 6557-6560   2001

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Books 11

  1. アメフラシから得られた抗腫瘍性物質 Reviewed

    北将樹、木越英夫( Role: Joint author ,  12章)

    海洋天然物化学(化学の要点シリーズ43)日本化学会編、共立出版  2023.8  ( ISBN:978-4320044845

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    Total pages:9   Responsible for pages:111-119   Language:Japanese Book type:General book, introductory book for general audience

  2. Chemical biology studies on aplyronine A, a PPI-inducing antitumor macrolide from sea hare Reviewed

    Masaki Kita( Role: Joint author)

    New Tide of Natural Product Chemistry, Eds. H. Ishikawa and H. Takayama (Springer Nature)  2023.6  ( ISBN:978-981-99-1713-6

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    Total pages:17   Responsible for pages:59-75   Language:English Book type:Scholarly book

    DOI: 10.1007/978-981-99-1714-3

  3. Discovery and use of natural products and derivatives as chemical probes. in The Discovery and Utility of Chemical Probes in Target Discovery. Reviewed

    M. Kita and H. Kigoshi( Role: Joint author)

    The Royal Society of Chemistry  2020.11 

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    Total pages:26   Responsible for pages:124-149   Language:English Book type:Scholarly book

    DOI: 10.1039/9781839160745-00124

  4. 巨大海洋分子の魅力. 天然物の化学–魅力と展望– 第7章

    北将樹( Role: Contributor)

    東京化学同人  2016.6 

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    Language:Japanese Book type:General book, introductory book for general audience

  5. 動物毒の世界. 天然物の化学–魅力と展望– 第15章

    北将樹( Role: Contributor)

    東京化学同人  2016.6 

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    Language:Japanese Book type:General book, introductory book for general audience

  6. Antitumor effects of sea hare-derived compounds in cancer. in Handbook of Anticancer Drugs from Marine Origin

    M. Kita and H. Kigoshi( Role: Joint author)

    Springer International Publishing Switzerland  2015 

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    Language:English Book type:Scholarly book

  7. Bioactive molecules from symbiotic marine dinoflagellates. in Marine Pharmacognosy: Trends and Applicatons

    M. Kita, T. Inuzuka, N. Maru, and D. Uemura( Role: Joint author)

    CRC Press, Taylor Francis, New York  2012 

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    Language:English Book type:Scholarly book

  8. Pheromones of marine invertebrates and algae. in Comprehensive Natural Products Chemistry. 2nd edition. Vol. 4

    M. Kita, M. Kitamura, and D. Uemura( Role: Joint author)

    Elsevier, Amsterdam  2010 

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    Language:English Book type:Scholarly book

  9. Diverse chemical structures and bioactivities of marine toxin: palytoxin and symbiodinolide. in Seafood and Freshwater Toxins. Pharmacology, Physiology and Detection. 2nd edition.

    M. Kita and D. Uemura( Role: Joint author)

    CRC Press, Boca Raton  2007 

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    Language:English Book type:Scholarly book

  10. Bioactive heterocyclic alkaloids from marine origin, in Topics in Heterocycles

    Kita, M.; Uemura, D.( Role: Joint author)

    Springer-Verlag Press  2006.11 

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    Language:English Book type:Scholarly book

  11. Shellfish poisons, in Progress in Marine Molecular Biotechnology

    Kita, M.; Uemura, D( Role: Joint author)

    Springer-Verlag Press  2006 

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    Language:English Book type:Scholarly book

▼display all

Presentations 93

  1. ケム・バイオハイブリッド合成法に基づく天然物創薬:赤痢アメーバ症治療薬の開発

    大倉優輝,緒方南海子, 北将樹, 渡辺賢二, 吉成浩一, 志津怜太, 森美穂子, 中野由美子, 野崎智義, 恒松雄太

    日本薬学会第143年会  2023.3.25  日本薬学会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道大学   Country:Japan  

  2. 海洋軟体動物アメフラシ由来細胞毒性物質の単離・構造決定とその起源の解明

    日置裕介, 庵下恵理, 佐藤達也, 岩尾豊紀, 河村篤, 恒松雄太, 北将樹

    日本化学会第103春季年会  2023.3.22  日本化学会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京理科大学野田キャンパス   Country:Japan  

  3. 天然由来の抗炎症・抗肥満リード化合物の探索と作用機序に関する研究

    平井里奈, 恒松雄太, 北将樹

    日本化学会第103春季年会  2023.3.22  日本化学会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京理科大学野田キャンパス   Country:Japan  

  4. 特徴的なMS2フラグメントイオンに基づく紅藻におけるアプリロニン類の検出

    庵下恵理, 日置裕介, 佐藤達也, 岩尾豊紀, 北将樹

    日本化学会第103春季年会  2023.3.22  日本化学会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京理科大学野田キャンパス   Country:Japan  

  5. トガリネズミおよび近縁哺乳類の臭腺に含まれる匂い物質の化学的研究

    鈴木麻佑子, 大舘智志, 北将樹

    日本農芸化学会2023年度大会  2023.3.15  日本農芸化学会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  6. トガリネズミ由来神経毒ペプチドBPP類の合成と生物活性評価

    定元千弥, 矢野佑介, 福岡凌, Andres D. Maturana, 大舘智志, 北将樹

    日本農芸化学会2023年度大会  2023.3.15  日本農芸化学会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  7. リガンド解離型ピレンプローブを用いた標的分子の同定と結合様式の解析

    海老原尚平, 津田智仁, 北将樹

    日本農芸化学会2023年度大会  2023.3.15  日本農芸化学会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  8. アクチン作用性天然物を利用した新規機能性分子の設計と合成

    板倉萌香, 田中健太郎, Didik H. Utomo, 北将樹

    日本農芸化学会2023年度大会  2023.3.15  日本農芸化学会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  9. 抗炎症および脂肪蓄積阻害活性を示すStylissatin類の作用機序

    抱岩歩美, 服部浩之, 柴田貴広, 北将樹

    日本農芸化学会2023年度大会  2023.3.15  日本農芸化学会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  10. トガリネズミ由来神経毒ペプチドのヒトアナログSynenkephalinの合成研究

    福岡凌, 矢野佑介, 定元千弥, Andres D. Maturana, 北将樹

    日本農芸化学会2023年度大会  2023.3.15  日本農芸化学会

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  11. Target identification and binding mode analysis using ligand-dissociation-type pyrene probes. Future Drug Discovery Empowered by Chemical Biology International conference

    S. Ebihara, T. Tsuda, M. Kita

    Future Drug Discovery Empowered by Chemical Biology  2023.2.21 

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    Event date: 2023.2

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  12. Engineering natural products by Chem-Bio hybrid synthesis for drug discovery of dysentery amoebiasis International conference

    Y. Okura, N. Ogata, M. Kita, K. Watanabe, R. Shizu, M. Mori, Y. Nakano, T. Nozaki, Y. Tsunematsu

    Future Drug Discovery Empowered by Chemical Biology  2023.2.21 

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    Event date: 2023.2

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  13. MS-based Targeted Isolation of New Aplaminone Derivatives from Aplysia kurodai and Elucidation of Their Accumulation from Local Red Algae International conference

    Y. Hioki, T. Sato, T. Iwao, A. Kawamura, Y. Tsunematsu, M. Kita

    4th International Conference on Natural Product Discovery and Development in the Genomic Era  2023.1.9  SIMB

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    Event date: 2023.1

    Language:English   Presentation type:Poster presentation  

    Venue:Manchester Grand Hyatt Hotel (San Diego, CA, USA)   Country:United States  

  14. ケム・バイオハイブリッド合成を駆使した赤痢アメーバ症治療薬の創製

    大倉優輝,緒方南海子, 北将樹, 渡辺賢二, 志津怜太, 森美穂子, 中野由美子, 野崎智義, 恒松雄太

    日本農芸化学会中部支部第193回支部例会  2022.10.1  日本農芸化学会中部支部

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋大学農学部   Country:Japan  

  15. 天然由来の抗炎症リード化合物の探索と作用機序に関する研究

    平井里奈,蛭川美奈子, 北将樹

    日本農芸化学会中部支部第193回支部例会  2022.10.1  日本農芸化学会中部支部

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋大学農学部   Country:Japan  

  16. ヒト炭酸脱水酵素hCA1を標的とする光親和性プローブの反応性評価

    中谷優寿,北将樹

    日本農芸化学会中部支部第193回支部例会  2022.10.1  日本農芸化学会中部支部

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋大学農学部   Country:Japan  

  17. トガリネズミ由来神経毒ペプチドのヒトアナログSynenkephalinの合成研究

    福岡凌,矢野佑介,定元千弥,北将樹

    日本農芸化学会中部支部第193回支部例会  2022.10.1  日本農芸化学会中部支部

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋大学農学部   Country:Japan  

  18. 食虫動物の臭腺に含まれるにおい成分に関する化学的研究

    鈴木麻佑子, 大舘智志, 北将樹

    日本農芸化学会中部支部第193回支部例会  2022.10.1  日本農芸化学会中部支部

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    Event date: 2022.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋大学農学部   Country:Japan  

  19. トガリネズミ由来神経毒ペプチドBPP類の合成, 構造決定と生物活性評価

    矢野佑介, 福岡凌, Andres D. Maturana, 大舘智志, 北将樹

    第64回天然有機化合物討論会  2022.9.7  天然有機化合物討論会

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:静岡市清水文化会館  

  20. アメフラシ由来新規細胞毒性物質の発見と分子ネットワーク解析を用いたその起源藻類の解明

    日置裕介, 栩野安友花, 佐藤達也, 岩尾豊紀, 河村篤, 北将樹

    第68回トキシンシンポジウム  2022.9.5  毒素シンポジウム

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  21. Target Proteins and Mode of Actions of Bioactive Marine Natural Products International conference

    M. Kita

    BIOLOGICS BY DESIGN 2022 in Asia  2022.7.28  Chemical Computing Group

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    Event date: 2022.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  22. 哺乳動物毒における化学コミュニケーションの解明

    北将樹

    新学術領域研究(化学コミュニ)取りまとめシンポジウム  2022.7.9  新学術領域研究(化学コミュニ)

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都大学薬学部   Country:Japan  

  23. 生物活性蛍光リガンドを用いた標的分子の結合様式解析 Invited

    北将樹

    第55回天然物化学談話会  2022.6.25  天然物化学談話会

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:オンライン   Country:Japan  

  24. 細胞夾雑系における生理活性蛍光リガンドを用いた標的分子の結合様式解析

    北将樹

    分子夾雑の生命化学 第6回領域会議  2022.1.28  新学術領域研究「分子夾雑の生命化学」

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    Event date: 2022.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京(オンライン)   Country:Japan  

  25. Binding mode analysis of target molecules on the cellular crowding systems using bioactive fluorescent probes International conference

    M. Kita

    2022.1.26 

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    Event date: 2022.1

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  26. Anti-inflammation and adipogenesis inhibition functions of stylissatin A: Structure-activity relationship, target identification, and mode of action studies Invited International conference

    (9) Masaki Kita, Menghua Zhang, Taiki Sunaba, Yiting Sun, Takahiro Shibata, Kazunori Sasaki, Hiroko Isoda, and Hideo Kigoshi

    The 2021 International Chemical Congress of Pacific Basin Societies (PACIFICHEM2021)  2021.12.18  PACIFICHEM2021

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    Event date: 2021.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:Hawaii, USA (on-line)   Country:United States  

  27. Chemical Biology and Ecology Studies on Aplyronine A, A PPI-inducing Antitumor Macrolide from Sea Hare Invited International conference

    M. Kita, D. H. Utomo, M. Morita, and H. Kigoshi

    The 2021 International Chemical Congress of Pacific Basin Societies (PACIFICHEM2021)  2021.12.18  PACIFICHEM2021

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    Event date: 2021.12

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Hawaii, USA (on-line)   Country:United States  

  28. Target identification and binding mode analysis of bioactive marine natural products Invited International conference

    M. Kita

    2021.11.22 

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    Event date: 2021.11

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  29. Target identification and binding mode analysis of bioactive natural products Invited International conference

    M. Kita

    2021.11.19  JSPS A3 Asian Chemical Probe Research Hub

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    Event date: 2021.11

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  30. Marine Natural Product Prospect for Human Health Invited International conference

    M. Kita

    The 5th International Conference of Medical and Health Sciences (ICMHS 5)  2021.8.25  Universitas Muhammadiyah Yogyakarta, Indonesia

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    Event date: 2021.8

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Universitas Muhammadiyah Yogyakarta, Indonesia   Country:Indonesia  

  31. Target Proteins and Mode of Actions of Bioactive Marine Natural Products. Invited International conference

    M. Kita

    The International Summer Course on Marine Natural Products (ISCMNP2021)   2021.8.23  ISCMNP2021

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    Event date: 2021.8

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Bogor Agricultural University, Indonesia (on-line)   Country:Indonesia  

  32. Natural Product Prospect for Human Health Invited International conference

    M. Kita

    79th Airlangga Webinar Conference Series, Airlangga University, Indonesia  2021.7.31  Airlangga University

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    Event date: 2021.7

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Indonesia (online)   Country:Indonesia  

  33. Chemical Communication on Insectivorous Mammals) Invited

    2021.3.18 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  34. 哺乳動物毒における化学コミュニケーションの解明

    北将樹, 矢野佑介, 鈴木麻由子, 荒井厚志, 森田真布, 稲垣英利

    新学術領域研究(化学コミュニ)第2回領域リトリート  2020.12.16  新学術領域研究(化学コミュニ)

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    Event date: 2020.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  35. タンパク質間相互作用を制御する海洋天然物 Invited

    北将樹

    第9回ケミカルバイオロジーセミナー  2020.12.10  信州大学農学研究科

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    Event date: 2020.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:オンライン   Country:Japan  

  36. タンパク質間相互作用を制御する海洋天然物 Invited

    北将樹

    第27回細胞生理学セミナー・GTRセミナー  2020.11.30  名古屋大学創薬科学研究科

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    Event date: 2020.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:オンライン   Country:Japan  

  37. リガンド解離型ピレンプローブを用いた標的分子の結合様式解析 Invited

    北将樹

    新学術領域研究(分子夾雑化学)第1回東海地区シンポジウム  2020.10.26  新学術領域研究(分子夾雑化学)

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    Event date: 2020.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:名古屋工業大学   Country:Japan  

  38. 細胞夾雑系における生理活性蛍光リガンドを用いた標的分子の結合様式解析

    北将樹

    新学術領域研究(分子夾雑化学)オンラインセミナー  2020.8.27  新学術領域研究(分子夾雑化学)

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Japan  

  39. タンパク質間相互作用を誘導する天然物の新展開 Invited

    北将樹

    第100回日本化学会春季年会・中長期シンポジウム 

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    Event date: 2020.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:東京理科大学野田キャンパス   Country:Japan  

  40. 哺乳動物毒における化学コミュニケーションの解明

    北将樹

    新学術領域(研究領域提案型)「化学コミュニケーションのフロンティア」第6回公開シンポジウム 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:慶應義塾大学矢上キャンパス   Country:Japan  

  41. 哺乳類由来の神経毒の化学生物学研究 Invited

    北将樹

    第42回日本分子生物学会年会・シンポジウム『トキシン』の織りなす多元的世界 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡国際会議場・マリンメッセ福岡   Country:Japan  

  42. 切れ味の良い分子を自然界にもとめて

    北将樹

    第1回名大・岐阜大農学シンポジウム 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  43. 切れ味の良い分子を自然界にもとめて Invited

    北将樹

    第3回函館セミナー 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  44. Bioorganic Studies on the Key Natural Products from Venomous Mammals and Marine Invertebrates Invited International conference

    Masaki Kita

    8th International Conference of the Indonesian Chemical Society (ICICS 2019) 

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    Event date: 2019.8

    Language:English   Presentation type:Oral presentation (keynote)  

    Country:Indonesia  

  45. 哺乳動物毒における化学コミュニケーションの解明

    北将樹

    新学術領域(研究領域提案型)「化学コミュニケーションのフロンティア」第5回公開シンポジウム 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  46. 生理活性蛍光リガンドを用いた標的分子の結合様式解析 Invited

    北将樹

    理研シンポジウム・第14回有機合成化学のフロンティア 

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    Event date: 2019.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:理化学研究所 鈴木梅太郎ホール   Country:Japan  

  47. 哺乳類由来の神経毒の化学生物学研究 Invited

    北将樹

    日本農芸化学会2019年度東京大会シンポジウム・ケミカルバイオロジーに基づく化学コミュニケーションの理解と制御 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  48. Chemical Communication on the Mammalian Venom International conference

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    Event date: 2019.1

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  49. PPI-inducing marine macrolide Invited International conference

    M. Kita

    6th Yangtze River Delta International Symposium on Marine Drugs 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:China  

  50. Specific protein-labeling and ligand-binding position analysis with amidopyrene probes as LDI MS tags International conference

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    Event date: 2018.10 - 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Korea, Republic of  

  51. 哺乳類由来の神経毒の化学生物学研究

    北将樹,武仲敏子,別所学,Andres D. Maturana,木越英夫,大舘智志,上村大輔

    第60回天然有機化合物討論会 

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    Event date: 2018.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:久留米   Country:Japan  

  52. 哺乳類由来の神経毒の化学生物学研究

    北将樹

    第65回トキシンシンポジウム 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  53. 哺乳動物毒における化学コミュニケーションの解明

    北将樹

    新学術領域(研究領域提案型)「化学コミュニケーションのフロンティア」第1回領域全体会議 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  54. リガンド解離型ピレンプローブを用いた標的分子における結合位置解析

    北将樹,渡邊礼,服部篤紀,胡亜萍,飯尾啓太,米田耕三,木越英夫

    日本ケミカルバイオロジー学会第13回年会 

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    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  55. 哺乳類由来の神経毒の化学生物学研究 Invited

    北将樹

    日本薬学会第138年会(金沢)シンポジウム・天然物パワー5:生物現象を制御する天然分子 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:金沢   Country:Japan  

  56. タンパク質−生物活性リガンド相互作用を解析するケミカルプローブの開発 Invited

    北将樹

    日本農芸化学会2018年度名古屋大会シンポジウム・ケミカルバイオロジー研究の最前線 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋   Country:Japan  

  57. Binding Position Analysis of Target Proteins Using LA-LDI MS International conference

    Gordon Research Conference, 2018 Marine Natural Products 

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    Event date: 2018.3

    Language:English   Presentation type:Poster presentation  

    Venue:Ventura, USA   Country:United States  

  58. 生理活性蛍光リガンドを用いた標的分子の結合様式解析 Invited

    北将樹

    Asian Chemical Probe Research Hub Symposium:天然物有機化学・天然物合成とケミカルバイオロジー 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:仙台   Country:Japan  

  59. Binding position analysis of target proteins using LA-LDI MS International conference

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    Event date: 2017.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:China  

  60. Development of the New Analytical Methods for the Binding Modes of Target Proteins Using LA-LDI MS Invited International conference

    M. Kita

    The 5th International Symposium on Transformative Bio-Molecules (ISTbM-5) 

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    Event date: 2017.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  61. タンパク質間相互作用を誘導する天然物の新展開 Invited

    北将樹

    統合物質創製化学研究推進機構 (IRCCS) 第一回若手の会 

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    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:犬山   Country:Japan  

  62. タンパク質間相互作用を誘導する有機小分子とその相互作用の解析法の開発 Invited

    北将樹

    MOEフォーラム2017 

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    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  63. タンパク質­リガンド相互作用を解析するリガンド解離型アミドピレンプローブの開発 International conference

    北将樹, 胡亜萍, 飯尾啓太, 渡邊礼, 米田耕三, 木越英夫

    日本ケミカルバイオロジー学会第12回年会 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:札幌   Country:Japan  

  64. タンパク質間相互作用を誘導する有機小分子 Invited

    北将樹

    第54回日本生物物理学会年会 菱化システム(株)ランチョンセミナー 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:つくば   Country:Japan  

  65. PPI-inducing marine macrolide. Invited International conference

    M. Kita

    8th US-Japan Symposium, 21st Century Innovations in Natural Products 

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:United States  

  66. 生理活性蛍光リガンドを用いた標的分子の結合様式解析 Invited

    北将樹

    平成28年度 筑波大学プレ戦略イニシアティブ「光と物質・生命科学のアンサンブルによる新現象の発掘と解明」キックオフシンポジウム 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:つくば   Country:Japan  

  67. タンパク質−生物活性リガンド相互作用を解析するケミカルプローブの開発 Invited

    北将樹

    第89回日本生化学会大会 シンポジウム「生物活性と創薬のケミカルバイオロジー」 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:仙台   Country:Japan  

  68. タンパク質−天然物リガンド相互作用を解析するケミカルプローブの開発 Invited

    北将樹

    新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」地区ミニシンポジウム 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  69. Recent Advances in the Study of Actin-targeting Natural Products. Invited International conference

    M. Kita

    4th Frontier Chemistry Center International Symposium (FCC2016, Hokkaido University) 

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    Event date: 2016.2

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  70. 切れ味の良い分子を自然界にもとめて Invited

    北将樹

    第6回横幹連合コンファレンス 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:名古屋   Country:Japan  

  71. 哺乳類由来の神経毒の化学生物学研究 Invited

    北将樹

    第38回日本分子生物学会・第88回日本生化学会合同大会 (BMB2015) ワークショップ 『最新の生物毒の多様性がおもしろい! 〜その構造と機能、進化そして利用について〜』 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:神戸   Country:Japan  

  72. Recent Advances in the Study of Actin-Targeting Natural Products. Invited International conference

    M. Kita

    Tsukuba Global Science Week (TGSW2015) 

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    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  73. Comparative Analysis of Toxicity In the Cuban Solenodon and Its Potential Role in the Species. Invited International conference

    M. Kita

    Vth International Wildlife Management Congress 2015 (IWMC2015) 

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    Event date: 2015.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  74. 哺乳類由来の神経毒の化学生物学研究 Invited

    北将樹

    第15回日本蛋白質科学会年会 ワークショップ「バイオインパクトマテリアル:その生体衝撃性の仕組みと応用性」 

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    Event date: 2015.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:徳島   Country:Japan  

  75. 光親和性プローブを用いた抗腫瘍性天然物の標的分子解析 Invited

    北将樹

    平成26年度化学系学協会東北大会 有機化学コロキウム「有機化学による生物へのアプローチ」 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:山形   Country:Japan  

  76. アクチン作用性天然物の新展開 Invited

    北将樹

    日本化学会第94春季年会 中長期テーマシンポジウム「ケミカルバイオロジーの新展開- 有機化学から発信するライフサイエンス新戦略II」 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋   Country:Japan  

  77. 抗腫瘍性物質アプリロニンAの標的分子および作用機序に関する研究 Invited

    北将樹

    第1回慶應有機化学若手シンポジウム 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:横浜   Country:Japan  

  78. Target Proteins and Mode of Actions of An Antitumor Macrolide Aplyronine A. Invited International conference

    M. Kita

    3rd Symposium on Creation of Functional Materials supported by Strategic Initiative A, University of Tsukuba 

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    Event date: 2012.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  79. 哺乳類由来の神経毒に関する生物有機化学的研究 Invited

    北将樹

    第59回トキシンシンポジウム 

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    Event date: 2012.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:帯広   Country:Japan  

  80. 抗腫瘍性物質アプリロニンAの標的分子および作用機序に関する研究 Invited

    北将樹

    新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」第1回若手ワークショップ 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  81. 有毒哺乳動物および海洋無脊椎動物由来の生物活性鍵物質に関する化学的研究 Invited

    北将樹

    日本化学会第92春季年会 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:横浜   Country:Japan  

  82. Bioorganic Studies on the Key Natural Products from Venomous Mammals and Marine Invertebrates. Invited International conference

    M. Kita

    Prof. G. W. K. Cavill Lecturship in 2011, The University of New South Wales 

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    Event date: 2011.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Australia  

  83. トガリネズミ,カモノハシ毒の謎に迫る -哺乳類の持つ毒の科学- Invited

    北将樹

    第84回日本生化学会大会 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:京都   Country:Japan  

  84. Bioorganic Studies on Mammalian Venoms: Neurotoxic Substances from Shrew and Platypus Invited International conference

    M. Kita

    The 27th International Symposium on the Chemistry of Natural Products (ISCNP27/ICOB7) and 7th International Conference on Biodiversity (ICOB7) 

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    Event date: 2011.7

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Australia  

  85. 哺乳類由来の神経毒に関する生物有機化学的研究 Invited

    北将樹

    第6回化学生態学研究会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:函館   Country:Japan  

  86. 進化と共生に着目した生物現象鍵物質の化学的研究 Invited

    北将樹

    筑波大学学際物質科学研究センター (TIMS, 白川センター) 第12回機能性分子シンポジウム 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:つくば   Country:Japan  

  87. 哺乳動物由来の神経毒に関する生物有機化学的研究 Invited

    北将樹

    日本化学会第90春季年会 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東大阪   Country:Japan  

  88. Bioactive Secondary Metabolites from Symbiotic Marine Dinoflagellates. Invited International conference

    M. Kita

    The Chemical Society of Japan (CSJ) Asian International Symposium 

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    Event date: 2010.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  89. Bioactive Secondary Metabolites from Symbiotic Marine Dinoflagellates. Invited International conference

    M. Kita

    The Royal Australian Chemical Institute New South Wales Natural Products Group Symposium 

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    Event date: 2007.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Australia  

  90. 哺乳動物由来の麻酔物質および致死性タンパク毒に関する研究 Invited

    北将樹

    第42回天然物化学談話会 

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    Event date: 2007.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:仙台   Country:Japan  

  91. Bioactive Metabolites from Symbiotic Marine Dinoflagellates. Invited International conference

    M. Kita

    3rd Yoshimasa Hirata Lectureship 

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    Event date: 2007.2

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  92. Study of the Lethal Venom from the Short-tailed Shrew Blarina brevicauda. Invited International conference

    M. Kita

    9th International Mammalogical Congress 

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    Event date: 2005.7 - 2005.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  93. A Unique Mammalian Lethal Venom in Saliva from A Short-tailed Shrew Blarina brevicauda is A Serine Protease. Invited International conference

    M. Kita

    International Symposium on "Medical and Biological Perspectives in Proteases and Their Inhibitors" 

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    Event date: 2003.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 17

  1. LA-LDI MSを用いた標的タンパク質の結合位置解析法の開発

    Grant number:JPMJPR1535  2015.10 - 2019.3

    戦略的創造研究推進事業(さきがけ)  さきがけ

    北将樹

      More details

    Grant type:Competitive

    Direct Cost: \40000000 、 Indirect Cost:\12000000 )

  2. 海洋由来慢性炎症性疾患治療リード化合物の創出

    2022.12 - 2025.3

    公益財団法人 アステラス病態代謝研究会 研究助成金 

    北 将樹

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000 ( Direct Cost: \2000000 )

  3. 哺乳類の適応進化に関わる神経毒ペプチドの機能解明

    2021.3 - 2023.4

    上原記念生命科学財団  上原記念生命科学財団 研究助成金 

    北 将樹

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5000000 ( Direct Cost: \5000000 )

  4. 哺乳類由来の神経毒の生物有機化学的研究

    2019.9 - 2021.3

    山田科学振興財団 研究援助 

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    Grant type:Competitive

    Grant amount:\1500000

  5. LA-LDI MSを用いた膜タンパク質とリガンドの新たな結合様式解析法の開発と応用

    2019.4 - 2020.3

    産総研-名大アライアンス事業 

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    Authorship:Principal investigator  Grant type:Collaborative (industry/university)

    Direct Cost: \1600000 )

  6. HBs抗原消失のバイオマーカー探索と新規HBワクチンの開発

    2018.4 - 2019.3

    肝炎等克服実用化研究事業  B型肝炎創薬実用化等研究事業

    北将樹

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\390000

  7. 哺乳類由来の神経毒の化学生物学研究

    2013.4 - 2016.3

    内藤記念科学振興財団若手ステップアップ研究助成 

    北将樹

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    Grant type:Competitive

    Grant amount:\10000000

  8. Conservation of endangered species through traditional lifestyles in Alejandro de Humboldt National Park, Cuba

    2012.4 - 2014.3

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    Grant type:Competitive

  9. 生物進化と海洋共生現象に注目した生物活性鍵物質の化学的研究

    2011.4 - 2013.3

    武田科学振興財団 

    北将樹

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    Grant type:Competitive

  10. 抗腫瘍活性を有する海洋天然物アプリロニンAの光親和性プローブ合成と作用機序解明

    2011.4 - 2013.3

    有機合成化学協会 Meiji Seikaファルマ研究企画賞 研究助成 

    北将樹

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    Grant type:Competitive

  11. 進化と共生に着目した生物現象鍵物質の化学的研究

    2010.4 - 2012.3

    内藤記念科学振興財団 

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    Grant type:Competitive

  12. カモノハシ由来の神経毒の化学生物学研究

    2010.4 - 2012.3

    上原記念生命科学財団 

    北将樹

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    Grant type:Competitive

  13. 哺乳動物由来の麻痺性神経毒およびプロテアーゼの構造と機能

    2009.4 - 2011.3

    (財)日本応用酵素協会 

    北将樹

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    Grant type:Competitive

  14. 陸棲哺乳類の麻痺性神経毒の構造と機能

    2008.4 - 2010.3

    加藤記念バイオサイエンス研究振興財団 

    北将樹

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    Grant type:Competitive

  15. 食虫動物トガリネズミの唾液麻酔性物質および致死性タンパク毒に関する生物有機科学的研究

    2005.4 - 2007.3

    内藤科学振興財団 

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    Grant type:Competitive

  16. 食虫動物ブラリナトガリネズミ由来の致死性タンパク毒に関する研究

    2005.4 - 2007.3

    井上科学振興財団 

    北将樹

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    Grant type:Competitive

  17. 摂餌行動刺激物質を利用したサンゴ食害生物モニタリングシステムの開発

    2002.4 - 2005.3

    新エネルギー・産業技術総合開発機構(NEDO)・産業技術研究助成 

    北将樹

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 21

  1. 共生体が持つ物質の多様性と生態系における新機能の解明

    Grant number:23H03823  2023.4 - 2026.3

    科学研究費助成事業  学術変革領域研究(B)

    恒松 雄太, 酒井 隆一, 北 将樹, 犬塚 俊康

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    Authorship:Coinvestigator(s) 

    天然有機化合物(天然物)は各々の生物種に備えられた特殊な代謝機構を介して生合成される物質である。化学構造的多様性が高く、歴史的には医薬品開発の探索源などとして利用されてきた。その一方、実環境に目を移すと、各生産生物がどのような意図で天然物産生を行っているのか?産生された物質の生態における生理的機能や役割は何か?といった根本的な問いについては理解が進んでいない。そこで本研究ではサンゴ-褐虫藻-細菌叢間の共生系に着目し、これら生物間において相互作用に働く鍵物質を同定する。「物質を介して生態系を俯瞰する」という新しい観点を基にした生物圏の生態情報と物質機能情報を紐付ける新たな研究手法を確立する。

  2. Analysis of cellular machinery using PPI-inducing small molecules

    Grant number:19H02839  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KITA Masaki

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    Authorship:Principal investigator 

    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

    We focused on the natural ligands that interact with actin, and aimed to identify new protein-protein interaction (PPI) functional points that could become the targets for drug discovery, and to elucidate the moving machinery associated with the cytoskeleton. We synthesized structurally-simplified actin-binding derivatives of the antitumor natural product aprilonin A (ApA), which induces unique PPI between actin and tubulin to inhibit microtubule dynamics. Using this compounds, we successfully affinity-purified cytoskeletal actin from cell lysate. In addition, molecular docking simulation and molecular dynamics studies succeeded in constructing a possible model of the actin-ApA-tubulin ternary complex in which the C7 TMSer ester interacted with tubulin, which is important for the potent cytotoxicity of ApA.

  3. Ecological and chemical surveys of endangered wildlife species endemic to the Caribbean region

    Grant number:16H05655  2016.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    KITA MASAKI

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    Authorship:Principal investigator 

    Grant amount:\13650000 ( Direct Cost: \10500000 、 Indirect Cost:\3150000 )

    We examined chemical ecological survey on Caribbean wild animals and plants, including an endangered mammal Cuban solenodon and local medicinal plants. Field surveys were conducted for a total of 140 days in the Republic of Cuba and the Dominican Republic, but solenodon was not captured. However, we have elucidated the evolutionary position of Cuban solenodon using DNA samples from individuals captured in previous studies, and newly found the anti-inflammatory effect of jacaranone isolated from the medicinal plant Jacaranda sp.

  4. Chemical Evolutionary Ecology Studies on the Repellent Substances from Shrews

    Grant number:20K21270  2020.7 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    KITA Masaki

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

    Shrews are unique mammals that have poisons in saliva, and it has been suggested that their muscle tissue contain insect repellent substances, and the odor glands contain odorants that repel large mammals. In this study, we aimed to discover novel functional substances related to predation derived from shrews, and to understand their roles in evolution. The enzymatic activity of salivary gland extracts were evaluated, and we established the presence of several serine proteases related to blood coagulation, such as kallikrein, plasmin, and thrombin. In addition, the volatile components contained in the odor grands were analyzed by GC-MS or other methods, and a macrolactone known as a musk odor substance was identified. In the future, we will synthesize the identified compounds, confirm their activities, and elucidate their physiological functions.

  5. Chemical Communication on the Mammalian Venom

    Grant number:20H04770  2020.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

  6. Binding mode analysis of target molecules on the cellular crowding systems using bioactive fluorescent probes

    Grant number:20H04703  2020.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

  7. Chemical communication of venomous mammals

    Grant number:18H04613  2018.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

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    Authorship:Principal investigator 

    Grant amount:\5200000 ( Direct Cost: \4000000 、 Indirect Cost:\1200000 )

  8. Development of peptides inhibiting tumor angiogenesis and metastasis to develop novel anti-cancer drug

    Grant number:15H02503  2015.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Kanaho Yasunori, FUJII Ikuo, KITA Masaki, FUNAKOSHI Yuji, YAMAUCHI Yohei, MIURA Yuki, MIYACHI Taito, Lin Yueh-Chen, Van Ngo Thai Bich, Tsai Meng-Tsz, FUJIWARA Daisuke, Tito Akindele, YONEDA kozou, YAMAGISHI kota

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    In this project, it was confirmed that the small G protein Arf6 positively regulates both tumor growth and invasion of cancer cells, and screened peptides inhibiting Arf6 activation to develop a novel anti-cancer drug. It was found that Arf6-specific GTPase-activating protein ARAP3 regulates invadopodia formation through inactivation of Arf6 in cancer cells, and that Arf6 expressed in lymphatic endothelial cells regulates tumor growth. These results demonstrate that Arf6 regulates both tumor growth and invasion/metastasis of cancer cells, and indicate that Arf6 is a candidate for developing a novel anti-cancer drug. When peptides inhibiting Arf6 activation were screened using the peptide library with about 35 amino acid residues, one peptide specifically inhibited Arf6 activation. Thus, a drug lead peptide for a novel anti-cancer drug development was successfully found.

  9. 光親和性プローブとLA-LDI-MSを用いた標的生体分子の結合部位解析法の開発

    2015.4 - 2017.3

    科学研究費補助金  挑戦的萌芽研究

    北 将樹

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    Authorship:Principal investigator 

  10. Study on Protein-Protein Interaction Induced by Marine Natural Products

    Grant number:26242073  2014.6 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Kigoshi Hideo

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    Authorship:Coinvestigator(s) 

    Marine macrolide, aplyronine A exhibits extremely strong antitumor activity by inducing protein-protein interaction (PPI) between two major cytoskeletons, actin and tubulin. In this study, we aimed to clarify structural factors for PPI and to develop the artificial analogs. Because the side-chain moiety binds to actin and the trimethylserine moiety in the macrolactone moiety interacts with tubulin, we design two hybrids from aplyronine A and the other actin-deplymerizing marine macrolides. Among them, hybrid from alyronine A and swinholide A shows same biological activity as aplyronine A, which is a simplified analog of aplyronine A.

  11. 海洋天然物の誘導するタンパク質-タンパク質相互作用の解明

    2014.6 - 2017.3

    科学研究費補助金  基盤研究(A)

    木越 英夫

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    Authorship:Coinvestigator(s) 

  12. 細胞骨格タンパク質の関わる抗腫瘍性発現機構の解明

    2014.4 - 2016.3

    科学研究費補助金  新学術領域研究

    木越 英夫

  13. 陸棲哺乳類の産生する麻痺性神経毒およびプロテアーゼの構造と機能

    2013.4 - 2016.3

    科学研究費補助金  若手研究(A)

    北 将樹

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    Authorship:Principal investigator 

  14. 腫瘍細胞増殖阻害活性を有する海洋天然物の新型作用機序の解明

    2011.11 - 2014.3

    科学研究費補助金  基盤研究(B)

    木越 英夫

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    Authorship:Coinvestigator(s) 

  15. 陸棲哺乳類の麻痺性神経毒の構造と機能

    2009.4 - 2013.3

    科学研究費補助金  若手研究(A)

    北 将樹

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    Authorship:Principal investigator 

  16. 共生現象鍵物質の化学的研究

    2009.4 - 2012.3

    科学研究費補助金  挑戦的萌芽研究

    北 将樹

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    Authorship:Principal investigator 

  17. 抗腫瘍性などの生物活性を有する海洋天然物の新型作用機序の解明

    2008.4 - 2011.3

    科学研究費補助金  基盤研究(B)

    木越 英夫

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    Authorship:Coinvestigator(s) 

  18. サンゴ食害生物の誘引物質に関する化学的研究

    2005.4 - 2007.3

    科学研究費補助金  若手研究(B)

    北 将樹

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    Authorship:Principal investigator 

  19. 生態系ダイナミズムに着目した物質探索法

    2004.6 - 2009.3

    科学研究費補助金 

    上村 大輔

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    Authorship:Coinvestigator(s) 

  20. キノコ由来の超生物活性物質に関する生物有機化学的研究

    2003.4 - 2005.3

    科学研究費補助金  若手研究(B)

    北 将樹

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    Authorship:Principal investigator 

  21. 複雑系天然有機分子の構造と機能

    2003.4 - 2004.6

    科学研究費補助金  基盤研究(A)

    上村 大輔

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    Authorship:Coinvestigator(s) 

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Industrial property rights 12

  1. 質量分析用プローブ

    北将樹,木越英夫

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    Applicant:北将樹,木越英夫

    Application no:特願2019-119846  Date applied:2019.6

    Country of applicant:Domestic  

  2. 炎症性疾患治療剤及びその使用

    礒田博子, 高橋真哉, 本嶋秀子, 坂巻碧, 渡邉信, 出村幹英, 吉田昌樹, 木越英夫, 北将樹, 齊藤啓太, 佐々木一憲

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    Application no:特願2016-020172  Date applied:2016.2

    Country of applicant:Domestic  

  3. 血圧降下剤

    上村大輔,北将樹,山田薫,諏佐智之,松本漠,大野智弘

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    Application no:特願2006-190173  Date applied:2006.7

    Country of applicant:Domestic  

  4. 新規安息香酸ベンジル誘導体及び医薬

    上村大輔、北将樹、松本漠、諏佐智之、山田薫、矢澤一良、山口宏二、叶茂

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    Application no: 特願2005-366790  Date applied:2005

    Country of applicant:Domestic  

  5. 脂肪細胞の脂肪蓄積阻害剤

    上村大輔、北将樹、大野美季、山田薫、大野智弘

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    Application no: 特願2005-28203  Date applied:2005

    Country of applicant:Domestic  

  6. 新規ペプチド誘導体及びこれを有効成分とする抗癌剤

    上村大輔、北将樹、丸範人、諏佐智之、山田薫

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    Application no: 特願2005-111394  Date applied:2005

    Country of applicant:Domestic  

  7. 血圧降下剤

    上村大輔、北将樹、山田薫、諏佐智之、松本漠、叶茂、矢澤一良、山口宏二、大野智弘

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    Application no:特願2005-212545  Date applied:2005

    Country of applicant:Domestic  

  8. 血圧降下剤

    上村大輔、北将樹、山田薫、諏佐智之、松本漠、大野智弘

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    Application no: 特願2005-212547  Date applied:2005

    Country of applicant:Domestic  

  9. ベンゾ[de]キノリン誘導体及びそれを有効成分とする医薬並びに食品

    上村大輔、北将樹、近藤美紀子、諏佐智之、禹済泰、李鍵炯、山田薫

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    Date applied:2004

    Announcement no: 特願2004-28830 

    Country of applicant:Domestic  

  10. トガリネズミ由来の新規セリンプロテアーゼ

    上村大輔、木戸博、北将樹、中村康男

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    Application no:特願2003-163495  Date applied:2003

    Country of applicant:Domestic  

  11. インダン誘導体及びこれを有効成分とする医薬

    上村大輔、北将樹、諏佐智之、照屋俊明、中川悟、仙石哲也、中野義勝 、山田薫、末永聖武

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    Application no: 特願2002-270875  Date applied:2002

    Country of applicant:Domestic  

  12. レイシガイダマシ類誘引剤

    上村大輔、北将樹、諏佐智之、照屋俊明、中川悟、仙石哲也、中野義勝、 山田薫、末永聖武

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    Application no:特願2002-356312  Date applied:2002

    Country of applicant:Domestic  

▼display all

 

Teaching Experience (On-campus) 47

  1. Laboratory in Chemistry

    2020

  2. Biomolecular Chemistry

    2020

  3. Organic Structural Analysis

    2020

  4. Seminar in Agricultural Sciences 2

    2020

  5. Organic Chemistry 2

    2020

  6. Bioorganic Chemistry

    2020

  7. ケミカルバイオロジー特論

    2020

  8. Bioorganic Chemistry

    2019

  9. 農学セミナー2

    2019

  10. 化学実験

    2019

  11. 生命分子化学

    2019

  12. 有機構造解析学

    2019

  13. 有機化学2

    2019

  14. 応用生命科学科実験

    2019

  15. ケミカルバイオロジー特論

    2019

  16. 農学セミナー2

    2018

  17. ケミカルバイオロジー特論

    2018

  18. 生物制御化学

    2018

  19. 有機構造解析学

    2018

  20. 応用生命科学科実験

    2018

  21. Bioorganic Chemistry

    2018

  22. 有機化学2

    2018

  23. 生命機能科学特論III

    2017

     詳細を見る

    生命農学研究科、修士学生向け、天然物ケミカルバイオロジー分野、分担

  24. 有機化学1

    2017

     詳細を見る

    農学部2年生向け

  25. 有機構造解析学

    2017

     詳細を見る

    農学部3年生向け

  26. 応用生命科学科実験

    2017

     詳細を見る

    応用生命科学科3年生向け、天然物化学分野の実験、分担

  27. Bioorganic Chemistry

    2017

  28. 生物制御化学

    2017

  29. 有機化学実験

    2007

     詳細を見る

    学部3年向け有機化学学生実験

  30. 化学講究III

    2007

     詳細を見る

    学部2年向け演習セミナー

  31. 化学講究III

    2006

     詳細を見る

    学部2年向け演習セミナー

  32. 有機化学実験

    2006

     詳細を見る

    学部3年向け有機化学学生実験

  33. 基礎化学実験

    2005

     詳細を見る

    学部2年向け有機化学学生実験

  34. 有機化学実験

    2005

     詳細を見る

    学部3年向け有機化学学生実験

  35. 化学講究III

    2005

     詳細を見る

    学部2年向け演習セミナー

  36. 基礎化学実験

    2004

     詳細を見る

    学部2年向け有機化学学生実験

  37. 有機化学実験

    2004

     詳細を見る

    学部3年向け有機化学学生実験

  38. 化学講究III

    2004

     詳細を見る

    学部2年向け演習セミナー

  39. 基礎化学実験

    2003

     詳細を見る

    学部2年向け有機化学学生実験

  40. 化学講究III

    2003

     詳細を見る

    学部2年向け演習セミナー

  41. 有機化学実験

    2003

     詳細を見る

    学部3年向け有機化学学生実験

  42. 基礎化学実験

    2002

     詳細を見る

    学部2年向け有機化学学生実験

  43. 化学講究III

    2002

     詳細を見る

    学部2年向け演習セミナー

  44. 有機化学実験

    2002

     詳細を見る

    学部3年向け有機化学学生実験

  45. 基礎化学実験

    2001

     詳細を見る

    学部2年向け有機化学学生実験

  46. 化学講究III

    2001

     詳細を見る

    学部2年向け演習セミナー

  47. 有機化学実験

    2001

     詳細を見る

    学部3年向け有機化学学生実験

▼display all

 

Social Contribution 3

  1. 生物間相互作用に関わる最新分子

    Role(s):Media coverage

    化学工業日報  特集 日本化学会第103春季年会 中長期テーマシンポジウム  2023.3

  2. 名古屋大学農学部の紹介

    Role(s):Lecturer

    時習館高等学校  2020.12

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    Audience: High school students

    Type:Visiting lecture

  3. 名古屋大学農学部の紹介

    Role(s):Lecturer

    岐阜北高等学校(オンライン)  2020.9

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    Audience: High school students

    Type:Visiting lecture