Updated on 2022/04/12

写真a

 
ARAKI, Satohiko
 
Organization
Graduate School of Science Lecturer
Graduate School
Graduate School of Science
Undergraduate School
School of Science
Title
Lecturer
Contact information
メールアドレス

Degree 2

  1. Master of Engineering ( Tokyo Institute of Technology ) 

  2. 博士(理学) ( 名古屋大学 ) 

Research Areas 2

  1. Others / Others  / Cell Death

  2. Others / Others  / Vascular Biology

Current Research Project and SDGs 3

  1. 血管内皮細胞の細胞間解離の分子機構

  2. Study on hemorrhagic snake toxin

  3. Apoptosis on Vascular Endothelial Cells

Education 3

  1. Nagoya University   Graduate School, Division of Natural Science

    - 1991

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    Country: Japan

  2. Tokyo Institute of Technology   Graduate School, Division of Engineering

    1984 - 1986

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    Country: Japan

  3. Tokyo Institute of Technology   Faculty of Engineering

    - 1984

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    Country: Japan

Professional Memberships 3

  1. トキシン・シンポジウム   運営委員

    2010.4 - 2012.3

  2. 日本生化学会

  3. 日本基礎老化学会

Committee Memberships 4

  1. 独立行政法人製品評価技術基盤機構   特許微生物寄託業務に係る技術開発委員会委員  

    2021.12 - 2022.3   

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    Committee type:Other

  2. 独立行政法人製品評価技術基盤機構   特許微生物寄託業務に係る技術開発委員会委員  

    2021.1 - 2021.3   

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    Committee type:Other

  3. 独立行政法人製品評価技術基盤機構   特許微生物寄託業務に係る技術開発委員会委員  

    2019.12 - 2020.3   

  4. 毒素シンポジウム   第62回トキシンシンポジウム実行委員会委員長  

    2014.9 - 2015.7   

 

Papers 40

  1. Bitiscetin-3, a Novel C-Type Lectin-like Protein Cloned from the Venom Gland of the Viper Bitis arietans, Induces Platelet Agglutination and Inhibits Binding of Von Willebrand Factor to Collagen Reviewed

    Youhei Nashimoto, Fumio Matsushita, Johannes M. Dijkstra, Yuta Nakamura, Hidehiko Akiyama, Jiharu Hamako, Takashi Morita, Satohiko Araki, Taei Matsui

    Toxins   Vol. 14 ( 236 ) page: 1 - 18   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi.org/10.3390/toxins14040236

  2. Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo Reviewed

    Seo T, Sakon T, Nakazawa S, Nishioka A, Watanabe K, Matsumoto K, Akasaka M, Shioi N, Sawada H, Araki S

    The FEBS jounal   Vol. 284 ( 11 ) page: 1657 - 1671   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/febs.14066

    Web of Science

  3. Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom

    Araki Satohiko

    SNAKE VENOMS     page: 145 - 159   2017

  4. Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom Invited

    S. Araki

    Snake Venoms, Toxinology     page: 145-159   2016

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    Authorship:Lead author   Language:English  

    DOI: 10.1007/978-94-007-6648-8_5-1

  5. Vascular apoptosis-inducing protein 1 Invited

    Satohiko Araki

    Handbook of Proteolytic Enzymes     page: 1036-1038   2013

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    Authorship:Lead author   Language:English  

  6. Effects of minerals and trace elements on apoptosis and necrosis of human vascular endothelial cells Reviewed

      ( 31 ) page: 1-8   2012

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  7. Hemorrhagic activity of the vascular apoptosis-inducing proteins VAP1 and VAP2 from Crotalus atrox Reviewed

    Kikushima E, Nakamura S, Oshima Y, Shibuya T, Miao JY, Hayashi H, Nikai T and Araki S

    Toxicon   Vol. 52   page: 589-593   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

  8. 血管細胞の破壊毒素:明らかになったADAM型細胞表面プロテアーゼの構造 Invited

    荒木聡彦、五十嵐智子、武田壮一

    表面   Vol. 46   page: 24-33   2008

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    Authorship:Lead author   Language:Japanese  

  9. Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins. Reviewed

    T. Igarashi, S. Araki, H. Mori, S. Takeda

    FEBS Lett.   Vol. 581 ( 13 ) page: 2416-2422   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

  10. cDNA Cloning and Some Additional Peptide Characterization of a Single-Chain Vascular Apoptosis-Inducing Protein, VAP2. Reviewed

    Masuda S, Maeda H, Miao JY, Hayashi H, Araki S.

    Endothelium   Vol. 14 ( 2 ) page: 89-96   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

  11. Crystallization and preliminary X-ray crystallographic analysis of the two vascular apoptosis-inducing proteins (VAPs) from Crotalus atrox venom. Reviewed

    Igarashi T, Oishi Y, Araki S, Mori H & Takeda S

    Acta Cryst F   Vol. 62   page: 688-691   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  12. Phosphatidylcholine-specific phospholipase C, p53 and ROS in the association of apoptosis and senescence in vascular endothelial cells. Reviewed

    Cheng,Y., Zhao, Q., Liu, X., Araki, S., Zhang, S., Miao, J.

    FEBS lett.   Vol. 580 ( 20 ) page: 4911-4915   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  13. Contrasting Effects of Phosphatidylinosital-and Phosphatidylcholine-Specific Phospholipase C on Apoptosis in Cultured Endothelial Cells. Reviewed

    Liu X, Zhao Q, Araki S, Zhang S, Miao J.

    Endothelium   Vol. 13 ( 3 ) page: 205-211   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  14. *Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold. Reviewed

    Soichi Takeda, Tomoko Igarashi, Hidezo Mori1, Satohiko Araki

    EMBO J   Vol. 25   page: 2388-2396   2006

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    Language:English   Publishing type:Research paper (scientific journal)  

  15. *Severe cell fragmentation in the endothelial cell apoptosis induced by snake apoptosis toxin VAP1 is an apoptotic characteristic controlled by caspases. Reviewed

    Maruyama J, Hayashi H, Miao J, Sawada H, and Araki S

    Toxicon   Vol. 46 ( 1 ) page: 1-6   2005

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    Language:English   Publishing type:Research paper (scientific journal)  

  16. Rattlesnake venom induces apoptosis by stimulating PC-PLC and upregulating the expression of integrin 4, P53 in vascular endothelial cells Reviewed

    Zhao Q, Araki S, Zhang S, Miao J

    Toxicon   Vol. 44 ( 2 ) page: 161-168   2004.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  17. Apoptosis Mediated by Phosphatidylcholine-Specific Phospholipase C is Associated with cAMP, p53 Level, and Cell-Cycle Distribution in Vascular Endothelial Cells. Reviewed

    Du C, Zhao Q, Araki S, Zhang S, Miao J

    Endothelium   Vol. 10 ( 3 ) page: 141-147   2003

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    Language:English   Publishing type:Research paper (scientific journal)  

  18. Involvement of specific integrins in apoptosis induced by vascular apoptosis-inducing protein 1 Reviewed

    Araki S, Masuda S, Maeda H, Ying MJ, Hayashi H.

    Toxicon   Vol. 40 ( 5 ) page: 535-542   2002.5

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

  19. *Purification, cDNA cloning and characterization of the vascular apoptosis-inducing protein, HV1, from Trimeresurus flavoviridis. Reviewed

    Masuda S, Hayashi H, Atoda H, Morita T, Araki S.

    Eur J Biochem   Vol. 268 ( 11 ) page: 3339-3345   2001.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  20. cDNA cloning and characterization of vascular apoptosis-inducing protein 1. Reviewed

    Masuda S, Ohta T, Kaji K, Fox JW, Hayashi H, Araki S.

    Biochem Biophys Res Commun.   Vol. 278 ( 1 ) page: 197-204   2000.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  21. Expression of bcl-2 gene increases in apoptosis of vascular endothelial cells induced by rattlesnske venom Reviewed

    Miao,J.Y, Araki,S., Zhang,S. and Hayashi,H

    Chinese Science Bulletin   Vol. 45   page: 1195-1198   2000

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    Language:English   Publishing type:Research paper (scientific journal)  

  22. 1-Methyl-3-isobutylxanthine delays apoptosis induced by deprivation of growth factors in vascular endothelial cells. Reviewed

    Miao JY, Araki S, Zhang SL, Hayashi H

    Acta Pharmacol Sin   Vol. 21   page: 936-938   2000

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    Language:English   Publishing type:Research paper (scientific journal)  

  23. Involvement of gene expressions in apoptosis of vascular endothelial cells induced by rattlesnake venom. Reviewed

    Miao JY, Araki S, Han YR, Hayashi H

    Cell Res   Vol. 9   page: 237-242   1999

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    Language:English   Publishing type:Research paper (scientific journal)  

  24. Effect of manoalide on apoptosis induced by deprivation of growth factors in vascular endothelial cells. Reviewed

    Miao JY, Araki S, Zhang HW, Hayashi H

    Zhongguo Yao Li Xue Bao   Vol. 20   page: 121-125   1999

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    Language:English   Publishing type:Research paper (scientific journal)  

  25. *Two vascular apoptosis-inducing proteins from snake venom are members of the metalloprotease/disintegrin family. Reviewed

    Masuda S, Hayashi H, Araki S

    Eur. J. Biochem.   Vol. 253   page: 36-41   1998

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    Language:English   Publishing type:Research paper (scientific journal)  

  26. Purification of vascular apoptosis inducing factor from hemorrhagic snake venom. Reviewed

    Masuda S, Araki S, Yamamoto T, Kaji K, Hayashi H

    Biochem. Biophys. Res. Com.   Vol. 235   page: 59-63   1997

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    Language:English   Publishing type:Research paper (scientific journal)  

  27. Integrin β4 is involved in apoptotic signal transduction of endothelial cells. Reviewed

    Miao JY, Araki S, Kaji K, Hayashi H

    Biochem. Biophys. Res. Com.   Vol. 233   page: 182-186   1997

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    Language:English   Publishing type:Research paper (scientific journal)  

  28. Fragments of Amiloid β induce apoptosis in Vascular Endothelial Cells. Reviewed

    Hase, M., Araki, S., and Hayashi, H

    Endothelium   Vol. 5   page: 221-229   1997

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    Language:English   Publishing type:Research paper (scientific journal)  

  29. Relationships between phosphatidylcholine-specific phospholipase C and integrins in cell-substratum adhesion and apoptosis in vascular endothelial cells. Reviewed

    Miao JY, Araki S, Hayashi H

    Endothelium   Vol. 5   page: 297-305   1997

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    Language:English   Publishing type:Research paper (scientific journal)  

  30. Supression of Apotosis in Vascular Endothelial Cells by inhibition of Phoshatidylcholine-Speciphic Phospholipase C. Reviewed

    Miao JY, Kaji K, Hayashi H, Araki S

    Endothelium   Vol. 5   page: 231-239   1997

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    Language:English   Publishing type:Research paper (scientific journal)  

  31. Inhibitors of phospholipase promote apotosis of human endothelial cells. Reviewed

    Miao JY, Kaji K, Hayashi H, Araki S

    J. Biochem.   Vol. 121   page: 612-618   1997

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    Language:English   Publishing type:Research paper (scientific journal)  

  32. 血管内皮細胞の老化とアポトーシス Invited

    荒木聡彦、林博司、加治和彦

      Vol. 33   page: 148-157   1996

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    Language:Japanese  

  33. 癌の血管新生をめぐって-血管新生とアポトーシス Invited

    荒木聡彦,苗俊英,山本達典,長谷真,林博司

      Vol. 9   page: 16-17   1996

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    Authorship:Lead author   Language:Japanese  

  34. Classification of signals for blocking apoptosis in vascular endothelial cells. Reviewed

    Hase M, Araki S, Kaji K, Hayashi H

    J. Biochem.   Vol. 116   page: 905-909   1994

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    Language:English   Publishing type:Research paper (scientific journal)  

  35. ヘビ毒による血管内皮細胞のアポトーシス Invited

    荒木聡彦、林博司

    実験医学   Vol. 11   page: 2312-2317   1994

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    Authorship:Lead author   Language:Japanese  

  36. Programmed cell death in response to alkyllysophospholipids in endothelial cells. Reviewed

    Araki S, Tsuna I, Kaji K, Hayashi H

    J Biochem   Vol. 115   page: 245-247   1994

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  37. Induction of apoptosis by hemorrhagic snake venoms in vascular endothelial cells. Reviewed

    Araki S, Ishida T, Yamamoto T, Kaji K, Hayashi H

    Biochem. Biophys. Res. Com.   Vol. 190   page: 148-153   1993

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  38. Programmed cell death in vascular system. Invited

    Araki S, Hayashi H

    Japanese Journal of Circulation Research   Vol. 15   page: 37-42   1992

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    Authorship:Lead author   Language:Japanese  

  39. *Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation. Reviewed

    Araki S, Shimada Y, Kaji K, Hayashi H

    Biochem. Biophys. Res. Com.   Vol. 168   page: 1194-1200   1990

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  40. Role of protein kinase C in the inhibition by fibroblast growth factor of apoptosis in serum-depleted endothelial cells. Reviewed

    Araki S, Simada Y, Kaji K, Hayashi H

    Biochem Biophys Res Commun   Vol. 172   page: 1081-1085   1990

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

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Books 5

  1. 抗出血性ヘビ毒抗体 ~Wntシグナル活性化を阻害してヘビ毒による出血を抑える

    荒木聡彦

    バイオテック東海  2018 

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    Responsible for pages:79   Language:Japanese Book type:General book, introductory book for general audience

  2. Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom.

    Araki S( Role: Joint author)

    Springer Netherlands  2016 

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    Language:English

  3. Vascular Apoptosis-Inducing Protein 1. Handbook of Proteolytic Enzymes

    Satohiko Araki( Role: Joint author)

    Academic Press  2013  ( ISBN:978-0-12-382219-2

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    Language:English

  4. 血小板血栓形成の分子機構

    荒木聡彦( Role: Joint author)

    アイプリコム  2002 

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    Language:Japanese

  5. 最新アポトーシス実験法

    荒木聡彦,加治和彦,林博司( Role: Joint author)

    羊土社  1995 

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    Language:Japanese

Presentations 3

  1. ヘビ毒ADAMが誘導する新しい細胞機構

    荒木聡彦、野中淳、瀬尾忠彦、澤田均

    第60回トキシンシンポジウム 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  2. 出血性ADAMプロテアーゼの作用と構造

    荒木聡彦

    生化学会九州支部会シンポジウム 

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    Event date: 2012

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  3. ADAM型出血性ヘビ毒素の新しい機能

    荒木聡彦

    第58回トキシンシンポジウム 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

Research Project for Joint Research, Competitive Funding, etc. 9

  1. 抗ヒトLRP6ヒト抗体の開発

    2020.7

    共同研究 

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    Authorship:Principal investigator  Grant type:Collaborative (industry/university)

  2. 新規細胞培養添加剤の細胞増殖活性の改良及び適用細胞種の拡大

    2013.8 - 2014.3

    研究成果最適展開支援事業(A-STEP) 

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    Grant type:Competitive

  3. ADAMプロテアーゼの特異的阻害剤の開発

    2011.8 - 2012.3

    研究成果最適展開支援プログラム(A-STEP) 

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    Grant type:Competitive

  4. 新規な細胞培養添加剤の開発

    2010.8 - 2011.3

    研究成果最適展開支援プログラム(A-STEP) 

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    Grant type:Competitive

  5. 牛胎児血清に代わる培養添加剤の開発

    2009 - 2010

    科学技術振興機構・シーズ発掘試験A 

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    Grant type:Competitive

  6. ADAMプロテアーゼの立体構造と作用機構の解明

    2004 - 2005

    武田科学振興財団 

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    Grant type:Competitive

  7. 血管内皮細胞特異的アポトーシス誘導機構の解明

    2004 - 2005

    花王芸術科学財団 

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    Grant type:Competitive

  8. 血管内皮細胞に対するアポトーシス誘導因子のX線結晶構造解析

    2004 - 2005

    千里ライフサイエンス振興財団 

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    Grant type:Competitive

  9. 新規細胞死起動因子の本体解明

    2003 - 2004

    名古屋大学学振基金 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. Elucidation of molecular mechanism on cancer invasion and vascular wall opening by using hemorrhagic snake venom.

    Grant number:18K07195  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Araki Satohiko

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    The mechanism of vascular wall opening in diapedeses of cancer cells and leukocytes is unknown. ADAM protease on cancer cell pseudopod and in hemorrhagic snake venom is known to involve with vascular wall opening. We have already suggested cleavable receptor LRP6 and LRP5 are involving with intercellular detachment on vascular endothelial cells. Here, we explored binding receptors of hemorrhagic snake ADAM in vascular endothelial cells. Snake ADAM toxin strongly binds to ADAMBP1, which antibody inhibit intercellular detachment on endothelial cells by the toxin. Additionally, we showed the toxin also binds to ADAMBP2,3,4 and 5.

  2. ADAM型出血毒素の新規シグナル伝達と細胞機能の解明

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  3. ニッチー造血幹細胞間におけるGタンパク質共役型受容体TM7XN1の機能解析

    2009.4 - 2012.3

    科学研究費補助金  基盤研究(C)

    長谷真

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    Authorship:Coinvestigator(s) 

Industrial property rights 6

  1. 抗ADAMタンパク質基質抗体及びその利用

    荒木聡彦

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    Date applied:2017.3

    Announcement no:2018-154608  Date announced:2018.10

    Patent/Registration no:7037165  Date issued:2022.3

    Rights holder:国立大学法人東海国立大学機構   Country of applicant:Domestic   Country of acquisition:Domestic

  2. 抗ADAMタンパク質基質抗体及びその利用

    荒木聡彦

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    Applicant:国立大学法人名古屋大学

    Application no:2017-054999  Date applied:2017.3

    Country of applicant:Domestic  

  3. ADAM作用阻害物質のスクリーニング方法、仮足の保存方法、仮足保持剤、仮足の制御物質のスクリーング方法、及びADAM作用阻害剤

    荒木聡彦

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    Application no:特願2011-099107  Date applied:2011.4

    Country of applicant:Domestic  

  4. 培地添加剤およびその利用

    荒木聡彦,松村貴晴

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    Application no:特願2010-276226  Date applied:2010.12

    Country of applicant:Domestic  

  5. ADAM作用阻害物質のスクリーニング方法、仮足の保存方法、仮足保持剤、仮足の制御物質のスクリーング方法、及びADAM作用阻害剤

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    Application no:特願2010-105681  Date applied:2010

    Country of applicant:Domestic  

  6. クサリヘビ科ヘビの毒腺由来のアポトーシス誘導性タンパク質、およびその利用

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    Application no:特願平9-154794  Date applied:1997

    Country of applicant:Domestic  

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Teaching Experience (On-campus) 27

  1. 基礎細胞生物学Ⅲ

    2017

  2. 生命化学Ⅱ

    2017

  3. 基礎セミナーB

    2017

  4. 生物学基礎Ⅰ

    2017

  5. 基礎生物学演習

    2017

  6. 基礎細胞生物学Ⅲ

    2016

  7. 生命化学Ⅱ

    2016

  8. 基礎生物学演習

    2016

  9. 生命化学Ⅱ

    2016

  10. 生物学基礎Ⅰ

    2016

  11. 生命化学Ⅱ

    2015

  12. 基礎細胞学Ⅲ

    2015

  13. 基礎セミナーB

    2015

  14. 生物学基礎Ⅰ

    2015

  15. 基礎生物学演習Ⅰ

    2015

  16. 生物化学Ⅱ

    2014

  17. 基礎細胞生物学Ⅲ

    2014

  18. 基礎生物学演習Ⅰ

    2014

  19. 生物学基礎Ⅰ

    2014

  20. 基礎細胞生物学Ⅲ

    2013

  21. 生物化学Ⅱ

    2013

  22. 基礎生物学演習Ⅰ

    2013

  23. 基礎セミナーB

    2012

  24. 基礎細胞生物学Ⅲ

    2012

  25. 生物化学Ⅱ

    2012

  26. 生物化学Ⅱ

    2011

  27. 基礎細胞生物学Ⅲ

    2011

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Academic Activities 2

  1. 特許微生物寄託業務に係る技術開発委員会

    Role(s):Review, evaluation

    独立行政法人製品評価技術基盤機構  2021.12 - 2022.3

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    Type:Scientific advice/Review 

  2. 特許微生物寄託業務に係る技術開発委員会

    Role(s):Review, evaluation

    独立行政法人製品評価技術基盤機構  2021.1 - 2021.3

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    Type:Scientific advice/Review