Organization
Graduate School of Science Lecturer
Graduate School
Graduate School of Science
Undergraduate School
School of Science
Title
Lecturer
Contact information
ARAKI, Satohiko
Degree 2
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Master of Engineering （ Tokyo Institute of Technology ）
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博士(理学) （ 名古屋大学 ）
Research Areas 2
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Others / Others / Cell Death
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Others / Others / Vascular Biology
Current Research Project and SDGs 3
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血管内皮細胞の細胞間解離の分子機構
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Study on hemorrhagic snake toxin
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Apoptosis on Vascular Endothelial Cells
Education 3
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Nagoya University Graduate School, Division of Natural Science
- 1991
Country： Japan
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Tokyo Institute of Technology Graduate School, Division of Engineering
1984 - 1986
Country： Japan
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Tokyo Institute of Technology Faculty of Engineering
- 1984
Country： Japan
Professional Memberships 3
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トキシン・シンポジウム 運営委員
2010.4 - 2012.3
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日本生化学会
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日本基礎老化学会
Committee Memberships 5
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独立行政法人製品評価技術基盤機構 特許微生物寄託業務に係る技術開発委員会委員
2022.12 - 2023.3
Committee type：Other
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独立行政法人製品評価技術基盤機構 特許微生物寄託業務に係る技術開発委員会委員
2021.12 - 2022.3
Committee type：Other
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独立行政法人製品評価技術基盤機構 特許微生物寄託業務に係る技術開発委員会委員
2021.1 - 2021.3
Committee type：Other
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独立行政法人製品評価技術基盤機構 特許微生物寄託業務に係る技術開発委員会委員
2019.12 - 2020.3
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毒素シンポジウム 第62回トキシンシンポジウム実行委員会委員長
2014.9 - 2015.7
Papers 41
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Nashimoto, Y; Matsushita, F; Dijkstra, JM; Nakamura, Y; Akiyama, H; Hamako, J; Morita, T; Araki, S; Matsui, T
TOXINS Vol. 14 ( 4 ) 2022.4
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Bitiscetin-3, a Novel C-Type Lectin-like Protein Cloned from the Venom Gland of the Viper Bitis arietans, Induces Platelet Agglutination and Inhibits Binding of Von Willebrand Factor to Collagen Reviewed
Youhei Nashimoto, Fumio Matsushita, Johannes M. Dijkstra, Yuta Nakamura, Hidehiko Akiyama, Jiharu Hamako, Takashi Morita, Satohiko Araki, Taei Matsui
Toxins Vol. 14 ( 236 ) page： 1 - 18 2022.3
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Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo Reviewed
Seo T, Sakon T, Nakazawa S, Nishioka A, Watanabe K, Matsumoto K, Akasaka M, Shioi N, Sawada H, Araki S
The FEBS jounal Vol. 284 ( 11 ) page： 1657 - 1671 2017.6
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Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom
Araki Satohiko
SNAKE VENOMS page： 145 - 159 2017
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Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom Invited
S. Araki
Snake Venoms, Toxinology page： 145-159 2016
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Vascular apoptosis-inducing protein 1 Invited
Satohiko Araki
Handbook of Proteolytic Enzymes page： 1036-1038 2013
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Effects of minerals and trace elements on apoptosis and necrosis of human vascular endothelial cells Reviewed
( 31 ) page： 1-8 2012
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Hemorrhagic activity of the vascular apoptosis-inducing proteins VAP1 and VAP2 from Crotalus atrox Reviewed
Kikushima E, Nakamura S, Oshima Y, Shibuya T, Miao JY, Hayashi H, Nikai T and Araki S
Toxicon Vol. 52 page： 589-593 2008
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血管細胞の破壊毒素：明らかになったADAM型細胞表面プロテアーゼの構造 Invited
荒木聡彦、五十嵐智子、武田壮一
表面 Vol. 46 page： 24-33 2008
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Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins. Reviewed
T. Igarashi, S. Araki, H. Mori, S. Takeda
FEBS Lett. Vol. 581 ( 13 ) page： 2416-2422 2007
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cDNA Cloning and Some Additional Peptide Characterization of a Single-Chain Vascular Apoptosis-Inducing Protein, VAP2. Reviewed
Masuda S, Maeda H, Miao JY, Hayashi H, Araki S.
Endothelium Vol. 14 ( 2 ) page： 89-96 2007
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Crystallization and preliminary X-ray crystallographic analysis of the two vascular apoptosis-inducing proteins (VAPs) from Crotalus atrox venom. Reviewed
Igarashi T, Oishi Y, Araki S, Mori H & Takeda S
Acta Cryst F Vol. 62 page： 688-691 2006
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Phosphatidylcholine-specific phospholipase C, p53 and ROS in the association of apoptosis and senescence in vascular endothelial cells. Reviewed
Cheng,Y., Zhao, Q., Liu, X., Araki, S., Zhang, S., Miao, J.
FEBS lett. Vol. 580 ( 20 ) page： 4911-4915 2006
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Contrasting Effects of Phosphatidylinosital-and Phosphatidylcholine-Specific Phospholipase C on Apoptosis in Cultured Endothelial Cells. Reviewed
Liu X, Zhao Q, Araki S, Zhang S, Miao J.
Endothelium Vol. 13 ( 3 ) page： 205-211 2006
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*Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold. Reviewed
Soichi Takeda, Tomoko Igarashi, Hidezo Mori1, Satohiko Araki
EMBO J Vol. 25 page： 2388-2396 2006
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*Severe cell fragmentation in the endothelial cell apoptosis induced by snake apoptosis toxin VAP1 is an apoptotic characteristic controlled by caspases. Reviewed
Maruyama J, Hayashi H, Miao J, Sawada H, and Araki S
Toxicon Vol. 46 ( 1 ) page： 1-6 2005
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Rattlesnake venom induces apoptosis by stimulating PC-PLC and upregulating the expression of integrin 4, P53 in vascular endothelial cells Reviewed
Zhao Q, Araki S, Zhang S, Miao J
Toxicon Vol. 44 ( 2 ) page： 161-168 2004.8
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Apoptosis Mediated by Phosphatidylcholine-Specific Phospholipase C is Associated with cAMP, p53 Level, and Cell-Cycle Distribution in Vascular Endothelial Cells. Reviewed
Du C, Zhao Q, Araki S, Zhang S, Miao J
Endothelium Vol. 10 ( 3 ) page： 141-147 2003
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Involvement of specific integrins in apoptosis induced by vascular apoptosis-inducing protein 1 Reviewed
Araki S, Masuda S, Maeda H, Ying MJ, Hayashi H.
Toxicon Vol. 40 ( 5 ) page： 535-542 2002.5
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*Purification, cDNA cloning and characterization of the vascular apoptosis-inducing protein, HV1, from Trimeresurus flavoviridis. Reviewed
Masuda S, Hayashi H, Atoda H, Morita T, Araki S.
Eur J Biochem Vol. 268 ( 11 ) page： 3339-3345 2001.6
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cDNA cloning and characterization of vascular apoptosis-inducing protein 1. Reviewed
Masuda S, Ohta T, Kaji K, Fox JW, Hayashi H, Araki S.
Biochem Biophys Res Commun. Vol. 278 ( 1 ) page： 197-204 2000.11
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Expression of bcl-2 gene increases in apoptosis of vascular endothelial cells induced by rattlesnske venom Reviewed
Miao,J.Y, Araki,S., Zhang,S. and Hayashi,H
Chinese Science Bulletin Vol. 45 page： 1195-1198 2000
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1-Methyl-3-isobutylxanthine delays apoptosis induced by deprivation of growth factors in vascular endothelial cells. Reviewed
Miao JY, Araki S, Zhang SL, Hayashi H
Acta Pharmacol Sin Vol. 21 page： 936-938 2000
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Involvement of gene expressions in apoptosis of vascular endothelial cells induced by rattlesnake venom. Reviewed
Miao JY, Araki S, Han YR, Hayashi H
Cell Res Vol. 9 page： 237-242 1999
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Effect of manoalide on apoptosis induced by deprivation of growth factors in vascular endothelial cells. Reviewed
Miao JY, Araki S, Zhang HW, Hayashi H
Zhongguo Yao Li Xue Bao Vol. 20 page： 121-125 1999
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*Two vascular apoptosis-inducing proteins from snake venom are members of the metalloprotease/disintegrin family. Reviewed
Masuda S, Hayashi H, Araki S
Eur. J. Biochem. Vol. 253 page： 36-41 1998
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Purification of vascular apoptosis inducing factor from hemorrhagic snake venom. Reviewed
Masuda S, Araki S, Yamamoto T, Kaji K, Hayashi H
Biochem. Biophys. Res. Com. Vol. 235 page： 59-63 1997
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Integrin β4 is involved in apoptotic signal transduction of endothelial cells. Reviewed
Miao JY, Araki S, Kaji K, Hayashi H
Biochem. Biophys. Res. Com. Vol. 233 page： 182-186 1997
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Fragments of Amiloid β induce apoptosis in Vascular Endothelial Cells. Reviewed
Hase, M., Araki, S., and Hayashi, H
Endothelium Vol. 5 page： 221-229 1997
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Relationships between phosphatidylcholine-specific phospholipase C and integrins in cell-substratum adhesion and apoptosis in vascular endothelial cells. Reviewed
Miao JY, Araki S, Hayashi H
Endothelium Vol. 5 page： 297-305 1997
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Supression of Apotosis in Vascular Endothelial Cells by inhibition of Phoshatidylcholine-Speciphic Phospholipase C. Reviewed
Miao JY, Kaji K, Hayashi H, Araki S
Endothelium Vol. 5 page： 231-239 1997
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Inhibitors of phospholipase promote apotosis of human endothelial cells. Reviewed
Miao JY, Kaji K, Hayashi H, Araki S
J. Biochem. Vol. 121 page： 612-618 1997
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血管内皮細胞の老化とアポトーシス Invited
荒木聡彦、林博司、加治和彦
Vol. 33 page： 148-157 1996
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癌の血管新生をめぐって－血管新生とアポトーシス Invited
荒木聡彦，苗俊英，山本達典，長谷真，林博司
Vol. 9 page： 16-17 1996
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Classification of signals for blocking apoptosis in vascular endothelial cells. Reviewed
Hase M, Araki S, Kaji K, Hayashi H
J. Biochem. Vol. 116 page： 905-909 1994
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ヘビ毒による血管内皮細胞のアポトーシス Invited
荒木聡彦、林博司
実験医学 Vol. 11 page： 2312-2317 1994
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Programmed cell death in response to alkyllysophospholipids in endothelial cells. Reviewed
Araki S, Tsuna I, Kaji K, Hayashi H
J Biochem Vol. 115 page： 245-247 1994
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Induction of apoptosis by hemorrhagic snake venoms in vascular endothelial cells. Reviewed
Araki S, Ishida T, Yamamoto T, Kaji K, Hayashi H
Biochem. Biophys. Res. Com. Vol. 190 page： 148-153 1993
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Programmed cell death in vascular system. Invited
Araki S, Hayashi H
Japanese Journal of Circulation Research Vol. 15 page： 37-42 1992
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*Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation. Reviewed
Araki S, Shimada Y, Kaji K, Hayashi H
Biochem. Biophys. Res. Com. Vol. 168 page： 1194-1200 1990
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Role of protein kinase C in the inhibition by fibroblast growth factor of apoptosis in serum-depleted endothelial cells. Reviewed
Araki S, Simada Y, Kaji K, Hayashi H
Biochem Biophys Res Commun Vol. 172 page： 1081-1085 1990
Books 5
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抗出血性ヘビ毒抗体 ～Wntシグナル活性化を阻害してヘビ毒による出血を抑える
荒木聡彦
バイオテック東海 2018
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Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom.
Araki S（ Role： Joint author）
Springer Netherlands 2016
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Vascular Apoptosis-Inducing Protein 1. Handbook of Proteolytic Enzymes
Satohiko Araki（ Role： Joint author）
Academic Press 2013 （ ISBN:978-0-12-382219-2 ）
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血小板血栓形成の分子機構
荒木聡彦（ Role： Joint author）
アイプリコム 2002
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最新アポトーシス実験法
荒木聡彦，加治和彦，林博司（ Role： Joint author）
羊土社 1995
Presentations 4
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ADAMと標的基質の結合様式への疎水結合の関与
田中郁也
第68回トキシンシンポジウム 2022.9.5 毒素シンポジウム
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ヘビ毒ADAMが誘導する新しい細胞機構
荒木聡彦、野中淳、瀬尾忠彦、澤田均
第60回トキシンシンポジウム
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出血性ＡＤＡＭプロテアーゼの作用と構造
荒木聡彦
生化学会九州支部会シンポジウム
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ADAM型出血性ヘビ毒素の新しい機能
荒木聡彦
第58回トキシンシンポジウム
Research Project for Joint Research, Competitive Funding, etc. 9
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抗ヒトLRP6ヒト抗体の開発
2020.7
共同研究
Authorship：Principal investigator Grant type：Collaborative (industry/university)
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新規細胞培養添加剤の細胞増殖活性の改良及び適用細胞種の拡大
2013.8 - 2014.3
研究成果最適展開支援事業（A-STEP）
Grant type：Competitive
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ADAMプロテアーゼの特異的阻害剤の開発
2011.8 - 2012.3
研究成果最適展開支援プログラム(A-STEP)
Grant type：Competitive
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新規な細胞培養添加剤の開発
2010.8 - 2011.3
研究成果最適展開支援プログラム(A-STEP)
Grant type：Competitive
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牛胎児血清に代わる培養添加剤の開発
2009 - 2010
科学技術振興機構・シーズ発掘試験Ａ
Grant type：Competitive
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ADAMプロテアーゼの立体構造と作用機構の解明
2004 - 2005
武田科学振興財団
Grant type：Competitive
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血管内皮細胞特異的アポトーシス誘導機構の解明
2004 - 2005
花王芸術科学財団
Grant type：Competitive
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血管内皮細胞に対するアポトーシス誘導因子のX線結晶構造解析
2004 - 2005
千里ライフサイエンス振興財団
Grant type：Competitive
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新規細胞死起動因子の本体解明
2003 - 2004
名古屋大学学振基金
Grant type：Competitive
KAKENHI (Grants-in-Aid for Scientific Research) 3
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Grant number：18K07195 2018.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Araki Satohiko
Authorship：Principal investigator
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
The mechanism of vascular wall opening in diapedeses of cancer cells and leukocytes is unknown. ADAM protease on cancer cell pseudopod and in hemorrhagic snake venom is known to involve with vascular wall opening. We have already suggested cleavable receptor LRP6 and LRP5 are involving with intercellular detachment on vascular endothelial cells. Here, we explored binding receptors of hemorrhagic snake ADAM in vascular endothelial cells. Snake ADAM toxin strongly binds to ADAMBP1, which antibody inhibit intercellular detachment on endothelial cells by the toxin. Additionally, we showed the toxin also binds to ADAMBP2,3,4 and 5.
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ＡＤＡＭ型出血毒素の新規シグナル伝達と細胞機能の解明
2010.4 - 2013.3
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
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ニッチー造血幹細胞間におけるＧタンパク質共役型受容体ＴＭ７ＸＮ１の機能解析
2009.4 - 2012.3
科学研究費補助金 基盤研究(C)
長谷真
Authorship：Coinvestigator(s)
Industrial property rights 6
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抗ＡＤＡＭタンパク質基質抗体及びその利用
荒木聡彦
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抗ADAMタンパク質基質抗体及びその利用
荒木聡彦
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ADAM作用阻害物質のスクリーニング方法、仮足の保存方法、仮足保持剤、仮足の制御物質のスクリーング方法、及びADAM作用阻害剤
荒木聡彦
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培地添加剤およびその利用
荒木聡彦,松村貴晴
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ADAM作用阻害物質のスクリーニング方法、仮足の保存方法、仮足保持剤、仮足の制御物質のスクリーング方法、及びADAM作用阻害剤
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クサリヘビ科ヘビの毒腺由来のアポトーシス誘導性タンパク質、およびその利用
Teaching Experience (On-campus) 29
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基礎実習
2023
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生物学実験
2023
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基礎細胞生物学Ⅲ
2017
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生命化学Ⅱ
2017
-
基礎セミナーＢ
2017
-
生物学基礎Ⅰ
2017
-
基礎生物学演習
2017
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基礎細胞生物学Ⅲ
2016
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生命化学Ⅱ
2016
-
基礎生物学演習
2016
-
生命化学Ⅱ
2016
-
生物学基礎Ⅰ
2016
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生命化学Ⅱ
2015
-
基礎細胞学Ⅲ
2015
-
基礎セミナーＢ
2015
-
生物学基礎Ⅰ
2015
-
基礎生物学演習Ⅰ
2015
-
生物化学Ⅱ
2014
-
基礎細胞生物学Ⅲ
2014
-
基礎生物学演習Ⅰ
2014
-
生物学基礎Ⅰ
2014
-
基礎細胞生物学Ⅲ
2013
-
生物化学Ⅱ
2013
-
基礎生物学演習Ⅰ
2013
-
基礎セミナーB
2012
-
基礎細胞生物学Ⅲ
2012
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生物化学Ⅱ
2012
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基礎細胞生物学Ⅲ
2011
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生物化学Ⅱ
2011
Teaching Experience (Off-campus) 1
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学びの社
2022.7 （Nagoya University）
Level：Other
Academic Activities 3
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特許微生物寄託業務に係る技術開発委員会
Role(s)：Review, evaluation
独立行政法人製品評価技術基盤機構 2023.12 - 2024.3
-
特許微生物寄託業務に係る技術開発委員会
Role(s)：Review, evaluation
独立行政法人製品評価技術基盤機構 2021.12 - 2022.3
-
特許微生物寄託業務に係る技術開発委員会
Role(s)：Review, evaluation
独立行政法人製品評価技術基盤機構 2021.1 - 2021.3