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プロスタグランジンEによるインドメタシン誘起胃損傷の抑制: EP受容体サブタイプとの関連招待有り

鈴木敬三, 荒木秀夫, 溝口博之, 竹内孝治

Cytoprotection & biology 8 巻頁： 31-34 2000年

一酸化窒素遊離型インドメタシンの小腸傷害性について招待有り

田中晶子, 溝口博之, 鈴木敬三, 加藤伸一, 竹内孝冶

Cytoprotection & biology 8 巻頁： 27-30 2000年

Protective effect of Irsogladine on monochloramine-induced gastric mucosal lesions in rats: a comparative study with rebamipide 査読有り

Yamamoto H, Umeda M, Mizoguchi H, Kato S, Takeuchi K.

World J. Gastroenterol. 5 巻 ( 6 ) 頁： 477-482 1999年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIM:To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH(2)Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective a ctivity.METHODS AND RESULTS:Oral administration of NH(2)Cl-(120mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs.Both irsogladine (1mg/kg-10mg/ kg,po) and rebamipide (30mg/kg-100mg/kg, po) dose dependently prevented the development of these lesions in response to NH(2)Cl, the effect of irsogladine was significant at 3mg/kg or greater, and that of rebamipide only at 100mg/kg. The protective effect of irsogladine on NH(2)Cl induced gastric lesions was significantly reduced by N( G) nitro L arginine methyl ester (L-NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L-NAME. Topical application of NH(2)Cl-(20mM)caused a marked reduction of potential difference (PD) in exvivo stomachs. This PD reduction was not affected by mucosal application of irso-gladine, but significantly prevented by rebamipide. The mucosal exposure to NH(4)OH (120mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH(4)OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L-NAME sensitive manner.CONCLUSION:These results suggest that (1)NH(2)Cl gen-erated either exogenously or endogenously damages the gastric mucosa, (2)both irsogladine and rebamipide protect the stomach against injury caused by NH(2)Cl,and (3)the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins.

Roles of endogenous prostaglandins and nitric oxide in gastroduodenal ulcerogenic responses induced in rats by hypothermic stress 査読有り

Takeuchi K, Suzuki K, Araki H, Mizoguchi H, Sugamoto S, and Umdeda M.

Journal of Physiology-Paris 93 巻 ( 5 ) 頁： 423-431 1999年11月

Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats 査読有り

Tanaka A, Kunikata T, Mizoguchi H, Kato S, and Takeuchi K.

Journal of Physiology and Pharmacology 50 巻 ( 3 ) 頁： 405-417 1999年9月

Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses 査読有り

Takeuchi K, Suzuki K, Yamamoto H, Araki H, Mizoguchi H, and Ukawa H.

Journal of Physiology and Pharmacology 49 巻 ( 4 ) 頁： 501-513 1998年12月

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