論文 - 溝口 博之
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Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. 査読有り
Alkam T, Nitta A, Furukawa-Hibi Y, Niwa M, Mizoguchi H, Yamada K, Nabeshima T.
Behav Brain Res. 210 巻 ( 2 ) 頁： 184-190 2010年7月
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Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy. 査読有り
Katsuno M, Adachi H, Minamiyama M, Waza M, Doi H, Kondo N, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, Sobue G.
J Neurosci. 30 巻 ( 16 ) 頁： 5702-5712 2010年4月
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Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice. 査読有り
Mizoguchi H., Ibi D., Takuma K., Toth E., Sato J., Itohara S, Nabeshima T, Yamada K.
The Open Behav Sci J. 4 巻 頁： 19-25 2010年4月
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Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. 査読有り
Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, Yamada K.
206 巻 ( 1 ) 頁： 32-37 2010年1月
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Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: Involvement of pallidotegmental neurons. 査読有り
Mizoguchi H, Arai S, Koike H, Ibi D, Kamei H, Nabeshima T, Kim HC, Takuma K, and Yamada K.
Psychopharmacology(Berl) 207 巻 ( 2 ) 頁： 235-243 2009年12月
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Mice Deficient for Glucagon Gene-Derived Peptides Display Normoglycemia and Hyperplasia of Islet {alpha}-Cells But Not of Intestinal L-Cells. 査読有り
Hayashi Y, Yamamoto M, Mizoguchi H, Watanabe C, Ito R, Yamamoto S, Sun XY, and Murata Y.
Mol Endocrinol. 23 巻 ( 12 ) 頁： 1990-1999 2009年12月
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Microglia activated with toll-like receptor 9 ligand CpG attenuate oligomeric amyloid β neurotoxicity in vitro and in vivo models of Alzheimer's disease. 査読有り
Doi Y, Mizuno T, Maki Y, Jin S, Mizoguchi H, Ikeyama M, Doi M, Michikawa M, Takeuchi H, and Suzumura A.
Am J Pathol. 175 巻 ( 5 ) 頁： 2121-2132 2009年11月
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RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction. 査読有り
Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKhann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K, Yan SS.
Proc Natl Acad Sci U S A. 106 巻 ( 47 ) 頁： 20021-20026 2009年11月
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*Matrix metalloprotease-9 inhibition improves amyloid β-mediated cognitive impairment and neurotoxicity in mice. 査読有り
Mizoguchi H, Takuma K, Fukuzaki E, Ibi D, Someya E, Akazawa K, Alkam T, Tsunekawa H, Mouri A, Noda Y, Nabeshima T, and Yamada K.
J Pharmacol Exp Ther. 331 巻 ( 1 ) 頁： 14-22 2009年10月
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Neonatal phencyclidine treatment in mice induces behavioral, histological and neurochemical abnormalities in adulthood. 査読有り
Nakatani-Pawlak A, Yamaguchi K, Tatsumi Y, Mizoguchi H and Yoneda Y.
Biol Pharm Bull. 32 巻 ( 9 ) 頁： 1576-1583 2009年9月
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Behavioral abnormality and pharmacologic response in social isolation-reared mice. 査読有り
Behav Brain Res. 202 巻 ( 1 ) 頁： 114-121 2009年8月
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Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood. 査読有り
Ibi D, Nagai T, Kitahara Y, Mizoguchi H, Koike H, Shiraki A, Takuma K, Kamei H, Noda Y, Nitta A, Nabeshima T, Yoneda Y, and Yamada K.
Neurosci Res. 64 巻 ( 3 ) 頁： 297-305 2009年7月
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GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice. 査読有り
Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Kamei H, Kim HC, and Yamada K.
Eur J Pharmacol. 602 巻 ( 1 ) 頁： 101-104 2009年1月
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Involvement of Pallidotegmental Neurons in Methamphetamine- and MK-801-Induced Impairment of Prepulse Inhibition of the Acoustic Startle Reflex in Mice: Reversal by GABA(B) Receptor Agonist Baclofen. 査読有り
Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Takahashi K, Kamei H, Nabeshima T, and Yamada K.
Neuropsychopharmacology 33 巻 ( 13 ) 頁： 3164-3175 2008年12月
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The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice. 査読有り
Alkam T, Nitta A, Mizoguchi H, Itoh A, Murai R, Nagai T, Yamada K, and Nabeshima T.
The Journal of Pharmacology and Experimental Therapeutics 327 巻 ( 1 ) 頁： 137-147 2008年10月
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Ovariectomy increases neuronal amyloid-beta binding alcohol dehydrogenase level in the mouse hippocampus. 査読有り
Fukuzaki E, Takuma K, Funatsu Y, Himeno Y, Kitahara Y, Gu B, Mizoguchi H, Ibi D, Koike K, Inoue M, Yan SD, and Yamada K.
Neurochem Int. 52 巻 ( 7 ) 頁： 1358-1364 2008年6月
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Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. 査読有り
Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y, Kamei H, Nagai T, Yoneda Y, Nabeshima T, and Yamada K.
Journal of Nuerochemistry 105 巻 ( 3 ) 頁： 921-932 2008年5月
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Restraining tumor necrosis factor-alpha by thalidomide prevents the amyloid beta-induced impairment of recognition memory in mice. 査読有り
Alkam T, Nitta A, Mizoguchi H, Saito K, Seshima M, Itoh A, Yamada K, and Nabeshima T.
Behavioural Brain Research 189 巻 ( 1 ) 頁： 100-106 2008年5月
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Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens. 査読有り
Fukakusa A, Nagai T, Mizoguchi H, Otsuka N, Kimura H, Kamei H, Kim HC, Nabeshima T, Takuma K, and Yamada K.
Journal of Nuerochemistry 105 巻 ( 2 ) 頁： 436-444 2008年4月
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Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits. 査読有り
Fukuzaki E, Takuma K, Himeno Y, Yoshida S, Funatsu Y, Kitahara Y, Mizoguchi H, Ibi D, Koike K, Inoue M, and Yamada K.
Neuroscience Letter 433 巻 ( 2 ) 頁： 141-145 2008年3月