研究者詳細 - 小川　靖

論文 - 小川　靖

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Anti-p80 coilin autoantibodies react with a conserved epitope and are associated with anti-DFS70/LEDGF autoantibodies 査読有り

Goto, N., Sugiura, K., Ogawa, Y., Watanabe, A., Onouchi, H., Tomita, Y., Muro, Y.

Journal of Autoimmunity 26 巻 ( 1 ) 2006年

Regulation of fibroblast growth factor-23 signaling by Klotho 査読有り

Kurosu, H., Ogawa, Y., Miyoshi, M., Yamamoto, M., Nandi, A., Rosenblatt, K.P., Baum, M.G., Schiavi, S., Hu, M.-C., Moe, O.W., Kuro-o, M.

Journal of Biological Chemistry 281 巻 ( 10 ) 2006年

Identification of novel pharmacological activities of an antifungal agent, nystatin, to promote dendritic cell maturation 査読有り

Ogawa, Y., Mizumoto, N., Tanaka, H., Matsushima, H., Takashima, A.

Journal of Investigative Dermatology 126 巻 ( 2 ) 2006年

HLA-associated production of anti-DFS70/LEDGF autoantibodies and systemic autoimmune disease 査読有り

Muro, Y., Ogawa, Y., Sugiura, K., Tomita, Y.

Journal of Autoimmunity 26 巻 ( 4 ) 2006年

Discovery of novel immunostimulants by dendritic-cell-based functional screening 査読有り

Mizumoto, N., Gao, J., Matsushima, H., Ogawa, Y., Tanaka, H., Takashima, A.

Blood 106 巻 ( 9 ) 2005年

Regulation of oxidative stress by the anti-aging hormone klotho 査読有り

Yamamoto, M., Clark, J.D., Pastor, J.V., Gurnani, P., Nandi, A., Kurosu, H., Miyoshi, M., Ogawa, Y., Castrillon, D.H., Rosenblatt, K.P., Kuro-O, M.

Journal of Biological Chemistry 280 巻 ( 45 ) 2005年

A case of refractory bullous pemphigoid with plasmapheresis-associated thrombopenia: Efficacy of pulsed intravenous cyclophosphamide therapy 査読有り

Ogawa, Y., Adachi, A., Okamoto, M., Hashimoto, T., Tomita, Y.

Journal of Dermatology 31 巻 ( 8 ) 2004年

Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain 査読有り

Ogawa, Y., Sugiura, K., Watanabe, A., Kunimatsu, M., Mishima, M., Tomita, Y., Muro, Y.

Journal of Autoimmunity 23 巻 ( 3 ) 2004年

Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients 査読有り国際誌

Okamoto, M., Ogawa, Y., Watanabe, A., Sugiura, K., Shimomura, Y., Aoki, N., Nagasaka, T., Tomita, Y., Muro, Y.

Journal of Autoimmunity 23 巻 ( 3 ) 頁： 257 - 66 2004年

記述言語：英語掲載種別：研究論文（学術雑誌）

Alopecia areata (AA) has been suspected to be an autoimmune disease, although there is no distinct evidence, we investigated the relationship between AA and autoantibodies against dense fine speckles 70 kDa (DFS70) in 111 patients with alopecia and 105 healthy controls. The sera from 59 out of 111 (53%) Japanese alopecia patients were positive for anti-nuclear antibody (ANA), as compared to the sera of 16 out of 105 (15%) healthy controls (p < 0.001). Twenty percent (22/111) of the alopecia patients were shown to be positive for the prevalence of anti-DFS70 antibodies, as compared to 8% (8/105) of the healthy controls (p < 0.01). IgG subclass analysis by ELISA showed that IgG1 and IgG2-anti-DFS70 antibodies were dominant in alopecia patients. The DFS70 gene expression in the hair structures was clearly detected in both those with and those without the anti-DFS70 antibody by RT-PCR. Immunohistochemical techniques showed that the DFS70 was localized predominantly in the outer root sheath (ORS) cells. The elevated anti-DFS70 antibodies in alopecia patients and the localization of the DFS70 in the ORS suggest that autoantibodies against the DFS70 are related to the etiology in a certain population of AA.

DOI： 10.1016/j.jaut.2004.07.004

Scopus

PubMed

The Successful Use of Topical Tacrolimus Treatment for a Chronic Actinic Dermatitis Patient with Complications of Idiopathic Leukopenia 査読有り

Ogawa, Y., Adachi, A., Tomita, Y.

Journal of Dermatology 30 巻 ( 11 ) 2003年

Autoantibody to thioredoxin reductase in an ovarian cancer patient 査読有り

Muro, Y., Ogawa, Y., Kato, Y., Hagiwara, M.

Biochemical and Biophysical Research Communications 242 巻 ( 2 ) 1998年

Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein 査読有り

Shimomura, A., Ogawa, Y., Kitani, T., Fujisawa, H., Hagiwara, M.

Journal of Biological Chemistry 271 巻 ( 30 ) 1996年

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